Digital Commons Network^™

Comparison Of Crop Yield Estimates Obtained From An Historic Expert System To The Physical Characteristics Of The Soil Components, Edward Barrow Rayburn, Tom Basden

Faculty & Staff Scholarship

No abstract provided.

Point Count System For Measuring Ground Cover From Digital Photos, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

Random Misalignment And Anisotropic Deformation Of The Nested Cladding Elements In Hollow-Core Anti-Resonant Fibers, Michael Petry, Rodrigo Amezcua-Correa, Md Selim Habib

Electrical Engineering and Computer Science Faculty Publications

Hollow-core anti-resonant fibers (HC-ARFs) are en route to compete with and surpass the transmission performance of standard single-mode fibers (SSMFs). Recently, nested cladding elements emerged as a key enabler in reaching ultra-low transmission losses over a wide bandwidth. However, implementing nested geometry features poses a great challenge even in the current state-of-the-art fiber fabrication technology, often leading to structural imperfections, which ultimately worsen overall fiber performance. This article provides insights into the impact of fabrication-based perturbations of the cladding elements on the transmission performance and identifies areas of highest susceptibility. The impact of random outer and nested cladding tube misalignments …

Evaluating The Influence Of Twitter Bots Via Agent-Based Social Simulation, Aldo Averza, Khaled Slhoub, Siddhartha Bhattacharyya

Electrical Engineering and Computer Science Faculty Publications

Social Media is used by many as a source of information for current world events, followed by publicly sharing their sentiment about these events. However, when the shared information is not trustworthy and receives a large number of interactions, it alters the public's perception of authentic and false information, particularly when the origin of these stories comes from malicious sources. Over the past decade, there has been an influx of users on the Twitter social network, many of them automated bot accounts with the objective of participating in misinformation campaigns that heavily influence user susceptibility to fake information. This can …

Enhancing Cybersecurity By Generating User-Specific Security Policy Through The Formal Modeling Of User Behavior, Arwa Alqadheeb, Siddhartha Bhattacharyya, Samuel Perl

Electrical Engineering and Computer Science Faculty Publications

Organizations today are faced with the difficult challenge of balancing the embrace of new and emerging technology, and securing their systems and data that support critical business functions. Although there have been significant advances in security enforcement technology, attackers are still able to compromise organizations and access. The impacts of computer intrusions have become so untenable that many organizations are looking at a drastic rethinking of their approach to the security of internal networks. This approach is called Zero Trust and it seeks to remove all notion of a trusted internal network boundary. The benefits of Zero Trust include significantly …

A Machine Learning Approach To Predicting Sep Events Using Properties Of Coronal Mass Ejections, Jesse Torres, Lulu Zhao, Philip K. Chan

Electrical Engineering and Computer Science Faculty Publications

Solar energetic particles (SEPs) can cause severe damage to astronauts and their equipment, and can disrupt communications on Earth. A lack of thorough understanding the eruption processes of solar activities and the subsequent acceleration and transport processes of energetic particles makes it difficult to forecast the occurrence of an SEP event and its intensity using conventional modeling with physics-based parameters. Therefore, in order to provide an advance warning for astronauts to seek shelter in a timely manner, we apply neural networks to forecast the occurrence of SEP events. We use the properties of coronal mass ejections (CMEs) archived in the …

Automatic Verification Of Multi-Agent Systems Security Properties Specified With Ltl, Kholud Alghamdi, Marius Silaghi

Electrical Engineering and Computer Science Faculty Publications

We propose a way to verify security requirements of critical multi-agent system processes by using logic representations and automatic reasoning. The typical multi-agent system considered in our work would be an election system with agents representing their users and aiming to ensure security. Relevant processes are authentication, voting, re-voting, and election verification. The security requirements commonly addressed in such a voting system are: no user can vote unless it got authenticated, no invalid vote should be counted, no vote should be counted twice, and each valid vote should be eventually counted. We show a model of such security requirements by …

Reproductive Regrets Among A Population-Based Sample Of U.S. Women, Arthur L. Greil, Michele H. Lowry, Andrea R. Burch, Kathleen Slauson-Blevins, Nicholas Park, Julia Mcquillan

Sociology & Criminal Justice Faculty Publications

Women have many reproductive options, but little is known about their regrets regarding prior reproductive choices and outcomes. Guided by the life-course and stratified reproduction perspectives, this study draws on an open-ended question about reproductive regrets from wave I of the National Survey of Fertility Barriers, a representative telephone survey of reproductive aged U.S. women conducted from 2004 to 2006. The authors classified regrets into five broad categories: (1) none, (2) problematic fertility, (3) unfulfilled fertility desires, (4) family, and (5) pregnancy experiences. The authors conducted the analyses separately by motherhood status. Logistic regression analysis revealed that regardless of parental …

Covid-19 Vaccination In Palestine/Israel: Citizenship, Capitalism, And The Logic Of Elimination, Nicolas Howard, Emily Schneider

Sociology & Criminal Justice Faculty Publications

Despite Israel’s responsibility under international law to combat the spread of contagious diseases and epidemics in its occupied territories, Israeli officials have refused to distribute COVID-19 vaccines to Palestinians in the West Bank and Gaza Strip. Through a critical discourse analysis of Israeli officials’ statements regarding Israel’s COVID-19 vaccination campaign, this paper explores how Israel evades this responsibility while presenting itself as committed to public health and human rights. We find that Israeli officials strategically present Palestinians as an autonomous nation when discussing COVID-19 vaccinations, despite Israel’s ongoing attempts to prevent the creation of a Palestinian state. Relatedly, Israel justifies …

Induction Immunotherapy Followed By Thoracic Radiation Without Chemotherapy In Unresectable Stage Iii Non-Small Cell Lung Cancer: A Case Series., Srikiran Dasari, Takefumi Komiya Md

PCI Publications and Projects

OBJECTIVE: Although concurrent chemoradiation has been the standard of care for unresectable stage III non-small cell lung cancer (NSCLC) due to increased survival and decreased disease progression, patients with poor performance status cannot tolerate chemotherapy toxicity well. Durvalumab, an immune checkpoint inhibitor targeting the programmed death receptor-1 (PD-1) / programmed death-ligand 1 (PD-L1) axis, demonstrated efficacy as maintenance therapy after definitive chemoradiation. However, the role of immunotherapy in those who cannot tolerate chemoradiation is unclear.

METHODS: This retrospective case series reports adult patients with PD-L1-expressing stage III NSCLC diagnosed at Parkview Cancer Institute from 2019-2021 and treated initially with pembrolizumab …

This Is Not A Drill: The War Against Antiracist Teaching In America, Kimberlé W. Crenshaw

Faculty Scholarship

On January 5, 2022, Professor Kimberlé Williams Crenshaw received the 2021 Triennial Award for Lifetime Service to Legal Education and the Legal Profession from the Association of American Law Schools (AALS). In this modified acceptance speech delivered at the 2022 AALS Awards Ceremony, she reflects on the path that brought her to this moment and the crisis over antiracist and social justice education that is unfolding today. Arguing that the legal academy bears a collective responsibility to fight back against the silencing of antiracist frameworks, she calls on legal educational institutions to confront their historical agnosticism toward racial subordination and …

The Short- And Long-Term Effects On The Microbiome Of Infants Who Are Exposed To Opioids In Utero, Dawson Brown-Ezell

Undergraduate Honors Theses

Introduction: The gut microbiome is believed to have a significant impact on health throughout the lifespan, and the influence of infant nutrition and other environmental factors are of particular interest in its development. The aim of this research project was to learn more about the microbiome and short chain fatty acid (SCFA) composition of toddlers of differing weights, considering birth history, environment, and diet. In East Tennessee, opioid misuse is a growing issue, and a number of participants in this study were exposed in utero. We also hoped to identify related effects on infant’s SCFA composition. Finally, it is known …

Loss Of Mmr And Tgfbr2 Increases The Susceptibility To Microbiota-Dependent Inflammation-Associated Colon Cancer, Elena Tosti, Ana S Almeida, Tam T T Tran, Mariel Barbachan E Silva, Pilib Ó Broin, Robert Dubin, Ken Chen, Amanda P Beck, Andrew S Mclellan, Eduardo Vilar, Aaron Golden, Paul W O'Toole, Winfried Edelmann

Faculty, Staff and Student Publications

Background and aims: Mutations in DNA mismatch repair (MMR) genes are causative in Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation rates, with mutations frequently accumulating at short repetitive DNA sequences throughout the genome (microsatellite instability). The TGFBR2 gene is one of the most frequently mutated genes in dMMR CRCs. Therefore, we generated an animal model to study how the loss of both TGFBR2 signaling impacts dMMR-driven intestinal tumorigenesis in vivo and explore the impact of the gut microbiota.

Methods: We generated VCMsh2/Tgfbr2 mice in which Msh2loxP and Tgfbr2loxP alleles are …

Recent Advances On Dna Base Flipping: A General Mechanism For Writing, Reading, And Erasing Dna Modifications, Ren Ren, John R Horton, Samuel Hong, Xiaodong Cheng

Faculty, Staff and Student Publications

The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified cytosine-5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine-have been discovered in eukaryotic DNA. In addition to cytosine carbon-5 modifications, cytosine and adenine methylated in the exocyclic amine-N4-methylcytosine and N6-methyladenine-are other modified DNA bases discovered even earlier. Each modified base can be considered a distinct epigenetic signal with broader biological implications beyond simple chemical changes. Since 1994, several crystal structures of proteins and enzymes involved in writing, reading, and erasing modified bases have become available. Here, we present a structural synopsis of writers, readers, and erasers of the modified …

A Phase I, Open-Label, Dose-Escalation Study Of The Ox40 Agonist Ivuxolimab In Patients With Locally Advanced Or Metastatic Cancers, Adi Diab, Omid Hamid, John A Thompson, Willeke Ros, Ferry A L M Eskens, Toshihiko Doi, Siwen Hu-Lieskovan, Samuel J Klempner, Bishu Ganguly, Catherine Fleener, Xiao Wang, Tenshang Joh, Ken Liao, Shahram Salek-Ardakani, Carrie Turich Taylor, Jeffrey Chou, Anthony B El-Khoueiry

Faculty, Staff and Student Publications

PURPOSE: Stimulation of effector T cells is an appealing immunotherapeutic approach in oncology. OX40 (CD134) is a costimulatory receptor expressed on activated CD4

PATIENTS AND METHODS: Adult patients (

RESULTS: The most common all-causality adverse events were fatigue (46.2%), nausea (28.8%), and decreased appetite (25.0%). Of 31 treatment-related adverse events, 30 (96.8%) were grade ≤2. No dose-limiting toxicities occurred. Ivuxolimab exposure increased in a dose-proportionate manner from 0.3 to 10 mg/kg. Full peripheral blood target engagement occurred at ≥0.3 mg/kg. Three (5.8%) patients achieved a partial response, and disease control was achieved in 56% of patients. Increased CD4

CONCLUSIONS: Ivuxolimab …

Inhibition Of The Cd47-Sirpα Axis For Cancer Therapy: A Systematic Review And Meta-Analysis Of Emerging Clinical Data, Ji Son, Rodney Cheng-En Hsieh, Heather Y Lin, Kate J Krause, Ying Yuan, Amadeo B Biter, James Welsh, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

CD47-SIRPα interaction acts as a "don't eat me" signal and is exploited by cancer to downregulate innate and adaptive immune surveillance. There has been intense interest to develop a mechanism of blockade, and we aimed to analyze the emerging data from early clinical trials. We performed a systematic review and meta-analysis of relevant databases and conference abstracts including clinical trials using CD47 and/or SIRPα inhibitors in cancer treatment. Nonlinear mixed models were applied for comparison of response and toxicity. We retrieved 317 articles, 24 of which were eligible. These included 771 response-evaluable patients with hematologic (47.1%) and solid tumors (52.9%). …

Cell-Directed Aptamer Therapeutic Targeting For Cancers Including Those Within The Central Nervous System, Jun Wei, Renduo Song, Aria Sabbagh, Anantha Marisetty, Neal Shukla, Dexing Fang, Hinda Najem, Martina Ott, James Long, Lijie Zhai, Maciej S Lesniak, Charles David James, Leonidas Platanias, Michael Curran, Amy B Heimberger

Faculty, Staff and Student Publications

Osteopontin (OPN) is produced by tumor cells as well as by myeloid cells and is enriched in the tumor microenvironment (TME) of many cancers. Given the roles of OPN in tumor progression and immune suppression, we hypothesized that targeting OPN with aptamers that have high affinity and specificity could be a promising therapeutic strategy. Bi-specific aptamers targeting ligands for cellular internalization were conjugated to siRNAs to suppress OPN were created, and therapeutic leads were selected based on target engagement and

Comparison Of Psma-Based 18f-Dcfpyl Pet/Ct And Pelvic Multiparametric Mri For Lesion Detection In The Pelvis In Patients With Prostate Cancer, Trinh T Nguyen, Priya R Bhosale, Guofan Xu, Tinsu Pan, Peng Wei, Yang Lu

Faculty, Staff and Student Publications

Purpose: To directly compare the performance of pelvic mpMRI versus recently approved and increasingly used PSMA-based 18F-DCFPyL PET/CT in intermediate-high risk and biochemical recurrent prostate cancer patient cohort while exploring their potential differing applications in specific clinical scenarios.

Methods: A retrospective analysis was performed on patients who had 18F-DCFPyL PET/CT and pelvic mpMRI done from September 2021 to January 2022 at a single institution. The inclusion criteria were paired exams within a 3-month interval. Exclusion criteria were intervening treatment between exams, a change in PSA by more than 50% and absolute difference more than 1 ng/mL, or concurrent history of …

Checkpoint Inhibitors As Immunotherapy For Fungal Infections: Promises, Challenges, And Unanswered Questions, Sebastian Wurster, Stephanie S Watowich, Dimitrios P Kontoyiannis

Faculty, Staff and Student Publications

Opportunistic fungal infections have high mortality in patients with severe immune dysfunction. Growing evidence suggests that the immune environment of invasive fungal infections and cancers share common features of immune cell exhaustion through activation of immune checkpoint pathways. This observation gave rise to several preclinical studies and clinical case reports describing blockade of the Programmed Cell Death Protein 1 and Cytotoxic T-Lymphocyte Antigen 4 immune checkpoint pathways as an adjunct immune enhancement strategy to treat opportunistic fungal infections. The first part of this review summarizes the emerging evidence for contributions of checkpoint pathways to the immunopathology of fungal sepsis, opportunistic …

An Autoencoder-Based Deep Learning Method For Genotype Imputation, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan-Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong-Wen Deng, Chaoyang Zhang

Faculty, Staff and Student Publications

Genotype imputation has a wide range of applications in genome-wide association study (GWAS), including increasing the statistical power of association tests, discovering trait-associated loci in meta-analyses, and prioritizing causal variants with fine-mapping. In recent years, deep learning (DL) based methods, such as sparse convolutional denoising autoencoder (SCDA), have been developed for genotype imputation. However, it remains a challenging task to optimize the learning process in DL-based methods to achieve high imputation accuracy. To address this challenge, we have developed a convolutional autoencoder (AE) model for genotype imputation and implemented a customized training loop by modifying the training process with a …

Recurrent Hgnet-Mn1 Altered (Astroblastoma Mn1-Altered) Of The Foramen Magnum: Case Report And Molecular Classification, Sricharan Gopakumar, Malcolm F Mcdonald, Himanshu Sharma, Claudio E Tatsui, Gregory N Fuller, Ganesh Rao

Faculty, Staff and Student Publications

Background: Astroblastoma is a rare primary brain tumor of unclear origin, often occurring in young patients less than 30-years-old. It typically arises supratentorially and is diagnosed based on histological features including vascular hyalinization and perivascular pseudorosettes. Recent molecular characterization of primary CNS high-grade neuroepithelial tumors with meningioma I alteration (HGNET-MN1) found that HGNET-MN1 and tumors with morphological signatures of astroblastoma clustered together. Further analysis revealed such astroblastomas have MN1 alteration and the 2021 WHO classification of tumors of the CNS now recognizes astroblastoma MN1-altered as a new entity.

Case description: Here, we present the case of …

Body Image Mediating The Relationship Between Personality Factors, Emotionality And Extraversion, And Psychological Well-Being In A Gender-Diverse And Queer Sample, Rachel Jones

Senior Independent Study Theses

Research has examined the relationship between personality factors, body image, and psychological well-being. Some researchers look at how the three variables interact and relate to each other. Previous research shows how different levels of Emotionality and Extraversion influence one’s body image and psychological well-being (Allen & Celestino, 2018; Kokko et al., 2013; Lie et al., 2015; Swami et al., 2008). One’s body image also influences their psychological well-being. Additionally, personality factors, such as high Emotionality and low Extraversion can lead to someone having worse body image and worse well-being (Allen & Celestino, 2018). In a questionnaire that was made up …

Desperate Democrats In The Reagan Revolution: A Party Determined To Win The White House, Matthew Maxwell Akins

Senior Independent Study Theses

Bill Clinton’s 1992 election to the presidency as a Democrat ended a series of defeats for that party on the presidential level. Clinton may have won the White House, but he did not do it alone. In the decade before his victory, the “New Democrats” worked to moderate the Democratic Party from within, responding to the presidential losses of 1980, 1984, and 1988. Scholars have explored this topic from many angles, but none have explored it from the perspective of these “New Democrats” in a way that traces their story from Al From and Gillis Long to the DLC and …

Spiritual And Sexual Simultaneity: The Fourteenth-Century Psalter Of Bonne Of Luxembourg, Zoe Johnson

Senior Independent Study Theses

No abstract provided.

Stroke Clustering And Fitting In Vector Art, Khandokar Shakib

Senior Independent Study Theses

Vectorization of art involves turning free-hand drawings into vector graphics that can be further scaled and manipulated. In this paper, we explore the concept of vectorization of line drawings and study multiple approaches that attempt to achieve this in the most accurate way possible. We utilize a software called StrokeStrip to discuss the different mathematics behind the parameterization and fitting involved in the drawings.

Creating An Arcgis Dashboard For Climate Data Management And Visualization, Sydney Noel Case

Senior Independent Study Theses

The College of Wooster Department of Earth Sciences has collected over the past 12 years (and continues to collect) hourly local climate indicator data including stream level and temperature, air temperature and pressure, precipitation levels, and relative humidity. This data is collected at the College’s research station, Fern Valley, located in Holmes County, Ohio and serves as a storytelling component for regional climate change. Upon initial investigation, the extensive dataset revealed a fundamental data storage problem within Earth Sciences, as there lacked a singular location to store complex datasets. Several technological solutions were explored to create a long-term data storage, …

“What Does The Black Legend Have To Do With Cusco?”: Un Discurso De La Alteridad, La Evangelización, Y El Arte Religioso En El Cusco Colonial, Cammy Bly

Senior Independent Study Theses

Este trabajo considera las representaciones gráficas y artísticas de la conquista y la evangelización de las Américas en el contexto de la construcción del yo y del otro de Tzvetan Todorov y la reconceptualización de La Leyenda Negra de Walter Mignolo. Todorov propone que la conquista de las Américas es la conquista que “el yo hace del otro” (Todorov 13). Según Todorov, la construcción de la alteridad, u otherness, motivó las acciones de los conquistadores en las Américas y puso a los indígenas en una posición social inferior. Además de la teoría de Todorov, Walter Mignolo utiliza el …

Unearthing The Effects Of European-American Settlement On A Northeast Ohio Kettle Lake Through Diatom Stratigraphy, Justine Paul A. Berina

Senior Independent Study Theses

Recently, wetland conservation has highlighted the necessity for assessing limnological changes following European-American settlement. A prior study at Brown's Lake (northeast Ohio) identified a stratigraphic sequence that shows an abrupt transition from organic-rich muds to several centimeters of a bright loess layer, then a recovery to organic-rich sediments near the top. Based on ²¹⁰Pb dates, the loess deposition occurred before 1846 CE, when a growing population cleared trees and farmed intensively. Likewise, organics had recovered after 1950 CE, when people abandoned farmland and practiced conservation tillage. However, the effects of settlement on limnology are poorly known. Diatoms (microscopic algae; …

Backlog Burner: An Adventure Into Automated Scheduling, Anjolaoluwa J. Olubusi

Senior Independent Study Theses

The focus of this independent study is to explain the nurse scheduling problem (NSP) and use it as a basis to create an automated scheduling program. The nurse scheduling problem is an operational research problem that sets to find an optimal hospital schedule that fulfills the needs of the hospital and the personal requests of the nurses. The majority of solutions for the nurse scheduling problem are often designed within a hospital setting. The objective of this independent study is to use the solutions of the nurse scheduling problem to develop an automated scheduling program for the College of Wooster …

Puffins, The Charismatic Clowns Of The Sea: Examining The Relationship Between Community Identity And The Social Construction Of Animals, Megan Henry Tuennerman

Senior Independent Study Theses

This study analyzes the factors, internal and external, that affect the relationship between community identity and the social construction of animals, and the ways in which that social construction impacts the environment. Studied through the lens of the relationship between Atlantic Puffins and the human communities they live near, these questions situate our understanding of human societies as within, as opposed to above, the environment. Without this perspective, enacting environmental protections across the globe is ineffective. The study was conducted using ethnographic methods, including 11 formal interviews with community members and experts, along with observations in Iceland and Canada. Results …