Digital Commons Network^™

Multi-Task Neuromuscular Generalization And Changes Through The Lifespan, Hannah Delaney Carey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mobility in everyday life requires executing and shifting between a broad assortment of functional tasks and resisting disturbances that could cause falls. Though the importance of successfully performing a variety of functional tasks is recognized and incorporated in clinical assessments (e.g., the Timed-Up-and-Go Test, Berg Balance Scale), little is understood about the underlying neuromuscular control required, or how it changes with age. The neuromuscular control for functional tasks such as walking is typically studied in isolation, or with variations on the same task. Characterizing the coordination required to produce and shift between a wider variety of tasks and resist external …

Exploiting Modulation Of The Blood-Brain And Blood-Tumor Barrier Permeability By Translational Focused Ultrasound For Therapeutic Delivery To Cns Metastases, Tasneem A. Arsiwala

Graduate Theses, Dissertations, and Problem Reports (ETD)

Transcranial low-intensity focused ultrasound is a unique technology to modulate the integrity of tight endothelial junctions and transiently increase BBB/BTB permeability to enhance therapeutic delivery. Despite promising early studies, present literature lacks agreement on key experimental conditions, which restricts our knowledge and the technique's widespread translation. This dissertation first provides a critical review of the current gaps in knowledge regarding the universal use of LiFUS in preclinical and clinical use. We then identify key parameters for translational and predictable opening of the BBB using a 3T MRI coupled with a clinical device. Our investigation highlights that passive permeability of the …

Student Understanding Of The Definite Integral When Solving Calculus Volume Problems, Krista Bresock

Graduate Theses, Dissertations, and Problem Reports (ETD)

The concept of integration appears in many different scientific fields, and students’ understanding of and ability to use the definite integral in applications is important to success in their STEM (science, technology, engineering, and mathematics) classes. One of the first types of application problems that students encounter is finding the volume of a solid using the definite integral. How students approach these problems and how they use the definite integral to find volumes can have an impact on their future use and understanding of the definite integral.

This study involves a deep and thorough investigation of how ten students understand …

Bottleneck Management Through Strategic Sequencing In Smart Manufacturing Systems, Sayantee Roy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nowadays, industries put a significant emphasis on finding the optimum order for carrying out jobs in sequence. This is a crucial element in determining net productivity. Depending on the demand criterion, all production systems, including flexible manufacturing systems, follow a predefined sequence of job-based machine operations. The complexity of the problem increases with increasing machines and jobs to sequence, demanding the use of an appropriate sequencing technique. The major contribution of this work is to modify an existing algorithm with a very unusual machine setup and find the optimal sequence which will really minimize the makespan. This custom machine setup …

System Development Of An Unmanned Ground Vehicle And Implementation Of An Autonomous Navigation Module In A Mine Environment, Jonas Amoama Bredu Jnr

Graduate Theses, Dissertations, and Problem Reports (ETD)

There are numerous benefits to the insights gained from the exploration and exploitation of underground mines. There are also great risks and challenges involved, such as accidents that have claimed many lives. To avoid these accidents, inspections of the large mines were carried out by the miners, which is not always economically feasible and puts the safety of the inspectors at risk. Despite the progress in the development of robotic systems, autonomous navigation, localization and mapping algorithms, these environments remain particularly demanding for these systems. The successful implementation of the autonomous unmanned system will allow mine workers to autonomously determine …

Understanding Vaccine-Induced Memory Responses To Develop The Next Generation Of Pertussis Vaccines, Kelly L. Weaver

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bordetella pertussis is a Gram-negative respiratory pathogen that can infect individuals of all ages and is notably responsible for infant fatalities. Pertussis (whooping cough) is a vaccine-preventable respiratory disease for which vaccines have been available in the United States since the 1940s. Whole cell pertussis vaccines kept incidence of pertussis under 5,000 cases per year, but were associated with reactogenicity issues. Following the introduction of less reactogenic acellular pertussis vaccines in the late 1990s, there have been noteworthy outbreaks of pertussis. For example, in 2012 there were over 50,000 reported cases of pertussis and 20 deaths in the U.S. The …

The Use Of Neural Networks In Accelerating Small Molecule Docking Of Gpcrs, John Barber

Graduate Theses, Dissertations, and Problem Reports (ETD)

Docking simulations are a vital virtual screening technique to identify potential drug candidates by predicting the binding score and position for protein-ligand interactions. As ligand libraries expand into the billions, the number of groups able to run these simulations decreases drastically. Here we propose a simple methodology allowing for more accessibility of docking large ligand libraries. This method uses simple molecular features and unsupervised learning to cluster like molecules. These clusters are then randomly sampled, creating a training set. A model is trained using the bag of bonds method and a simple neural network to predict the binding affinity of …

Noise Exposure Trends Among Violating Coal Mines, 2000 To 2021, Hanna Grace Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Noise-induced hearing loss has continued to be a significant issue within the mining industry, even after the passing of the MSHA’s improved noise standard in 2000. NIOSH has recognized that the noise standard enacted by both MSHA and OSHA does not properly protect workers with the 5 dBA exchange rate (i.e., the increase in noise level leading to a doubling of energy) and the lack of emphasizing the use of engineering controls over administrative controls and overreliance on hearing protection device usage. The primary objective of this study is to investigate statistical sound relationships between MSHA noise-related violations and samples …

The Dances Of Diplomacy: French Social Dance Culture In The United States, 1780-1800, Kaylar Gina Moser

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis explores how social dancing in the United States formed a noteworthy aspect of political, diplomatic, social, and class exchange for U.S. elites both domestically and overseas; and how the cultural dominance over dance that France enjoyed during this period created an informal cultural diplomatic relationship between the United States and France in the 1780s and the 1790s. I argue that U.S. elites utilized this dance culture as a form of upper-class status legitimation that could serve diplomatic purposes. This project increases the purview of U.S. cultural diplomatic studies by centering on the eighteenth century and by utilizing an …

Living On The Edge: Trans* Exclusion, Survival, And Resistance, Rayna E. Momen

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

This dissertation focuses on the criminalization and victimization of transgender people, broadly defined as people whose gender identity does not align with their assigned birth sex, using a queer criminological and intersectional lens. The introduction offers background and context for this examination, and includes the purpose, theoretical approach, methodology, research questions, contributions, and overviews of the substantive chapters. Chapter two explores what we know and what we do not know about transgender people’s pathways into the criminal legal system, how they experience state surveillance, and how they navigate the system. Chapter three explores violence against transgender people in various …

Calcite Depression In Bastnaesite-Calcite Flotation System Using Organic Acids, Emmy Muhoza

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bastnaesite is the primary source of light REEs, namely cerium (Ce), lanthanum (La), praseodymium (Pr), neodymium (Nd), to name a few. Bastnaesite is typically concentrated using the froth flotation beneficiation method. Flotation of bastnaesite suffers from high reagent consumption due to the similar surface characteristics of bastnaesite and associated gangue minerals, including calcite. Additionally, complex stages of high-temperature conditioning are often required to suppress the detrimental impact of dissolved calcium ions on the flotation of bastnaesite. This research seeks to investigate the capabilities of organic acids in the bastnaesite-calcite flotation systems to selectively depress calcite minerals and effectively chelate calcium …

The Impacts Of Maple Syrup Production On The Herbaceous Layer In Appalachian Hardwood Forests, Logan Scott Ferguson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Vegetation data were collected from eight maple syrup farms (sugarbushes) and eight undeveloped maple-dominated sites to examine potential differences in understory plant communities due to disturbance effects. Understory plants were identified to the species level and percent cover of aboveground leaf-area for each species was estimated within 600 total quadrats. Overstory data and environmental data were collected to help determine if they had any effect on herbaceous-layer plant communities. Species richness, Shannon diversity, and Pielou’s evenness were calculated, with the analysis showing no significant differences between the site types. The absolute cover of plant functional groups was also compared between …

Artificial Intelligence Based Approach For Rapid Material Discovery: From Chemical Synthesis To Quantum Materials, Robert Tempke

Graduate Theses, Dissertations, and Problem Reports (ETD)

With the advent of machine learning (ML) in the field of Materials Science, it has become obvious that trained models are limited by the amount and quality of the data used for training. Where researchers do not have access to the breadth and depth of labeled data that fields like image processing and natural language processing enjoy. In the specific application of materials discovery, there is the issue of continuity in atomistic datasets. Often if one relies on experimental data mined from literature and patents this data is only available for the most favorable of atomistic data. This ultimately leads …

Exploration Of Intercollegiate Student-Athletes’ Athletic Identity, Leah C. Oldham

Graduate Theses, Dissertations, and Problem Reports (ETD)

Student-athletes encounter experiences that can cause their identity process and self-concept to be disturbed. Even though athletic identities are strong among intercollegiate athletes, some encounter identity-threatening events that interrupt their identity process, negatively affecting their athletic identity. The present study adds to current research on the athletic identity of student-athletes by examining the athletic identity and self-esteem of student-athletes to determine if a redshirt season is a positive (identity-enhancing) or negative (identity-threatening) event. The intersectionality of age, race, gender, and ethnicity are examined to understand if multiple identities influence the experience of a redshirt season. Results reveal that a redshirt …

Aerodynamic Analysis Of Damage State Missiles Using Overset Meshing Techniques For Application To Computational Fluid Dynamics Simulation, Jonathan A. D'Alessio

Graduate Theses, Dissertations, and Problem Reports (ETD)

Significant research over the years has aimed to redefine the flight capabilities of aircraft after sustaining structural damage to critical components. Flight survivability and controllability are key areas of concern when designing fault-tolerant flight control systems to handle a wide range of potential scenarios. However, there is a lack of research on the impact of physically damaged missile systems. Missile counter-defense and intercept capabilities have become more advanced as the United States has focused heavily on these areas over the years. Damaged missiles due to a kinetic intercept capability present an opportunity for analysis of the post-damage implications on flight …

Characterizing Locomotor Disturbance Perception In Young Adults, Daniel James Liss

Graduate Theses, Dissertations, and Problem Reports (ETD)

Falls during walking are a leading cause of injuries across aging. Many of these falls are due to slips and trips. The ability to perceive disturbances to ongoing motion may play an important role in the control of walking balance. However, disturbance perception has been investigated in standing balance, but its role in walking balance due to slip- and trip-like disturbances remains largely unknown. Characterizing locomotor disturbance perception in young adults may lead to a more comprehensive understanding of sensorimotor walking balance control.

This work defined locomotor disturbance perception in response to slip and trip-like disturbances in young adults. We …

Physical Educators’ Socialization And Self-Efficacy Toward The Behavior Management Of Students With Disabilities, Amelia Chloe Simpson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Intro: Although studies have evaluated how physical educators learn behavior management, little effort has been made to identify the socializing experiences and sources of self-efficacy that influence how physical educators approach the behavior management of students with disabilities (SWD).

Purpose: The purpose of this study was to understand how physical educators develop self-efficacy toward the behavior management of SWD throughout the phases of occupational socialization theory.

Method: Data for the mixed-method study included 85 U.S. public (K-12) physical educators who completed a survey that collected demographic information and responses to the Teaching Students with Disabilities Efficacy Scale (Solomon & Scott, …

Cycle Decomposition For Integral Current Homology, Kristin Julia Duling

Graduate Theses, Dissertations, and Problem Reports (ETD)

A standard graph theoretical result states that every element of the cycle space of a graph has a cycle decomposition. Georgakopoulos expands this result to a primitive decomposition and minimal representation of each element in a modified 1-dimensional singular homology. We modify the m-dimensional integral current homology in order to ensure a primitive decomposition for each element.

Roles And Responsibilities Of A Coach Developer In A Youth Soccer Setting In The United States, Christina Ann Villalon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although coaching has a long history guided in the apprenticeship or mentorship model (Taylor & Garratt, 2013), research has primarily focused on the athlete, rarely on the coach, and almost never on whom the coach is serving as an apprentice to, or being mentored or supported by. Internationally, this role has been termed a ‘coach developer,’ but the formalized title and role of the coach developer is still a rather new concept (ICCE, 2014), with most research focused on the coach developer working at elite levels. Therefore, the purpose of this study was to explore the roles and responsibilities of …

Modeling Nonlinear Dynamic Systems Using Bss-Anova Gaussian Process, Kyle Matthew Hayes

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nonlinear dynamic systems are some of the most common variety of systems encountered in the sciences, but are the potentially more onerous to model through system identification than static systems due to their added complexity, sensitivity to initial conditions, and the potential application of new dynamic and nonlinear behavior through any time dependent forcing functions. The BSS-ANOVA Gaussian Process is a Machine Learning method for dynamic system ID that possesses several attributes that make it a natural candidate for this variety of problem. BSS-ANOVA is fully Bayesian, works best for continuous tabular datasets, and fast training and inference times and …

Possible Paths Forward For A Practice-Based Teacher Education Centered On Justice, Joshua Harlan Karr

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation seeks to address limitations of Practice-Based Teacher Education (PBTE) in relation to (1) narrow conceptions of practice and teacher learning, and (2) peripheralization of equity and justice. After aiming to understand the landscape of limitations in PBTE, this study situates itself within specific manifestations of these limitations that exist in common conceptualizations of teacher learning and practice-based pedagogies. To (re)emphasize the situated nature of practice and center equity and justice in PBTE, I theorize an expanded notion of teacher learning, develop design features for contextually situated pedagogies of practice (Grossman et al., 2009), and implement the design with …

Wetland Mitigation Performance Standards: The Intersection Of Science, Practice, And Policy, Jessica Anne Bryzek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wetland ecosystem spatial extent and integrity have declined due to conversion to anthropogenic land uses. Wetland mitigation offsets the impact on wetlands encountered during development by restoring a previously degraded wetland or creating new wetlands. This activity creates an ecosystem service market where wetland impacts (debits) are offset by wetland restoration/creation (credits). Mitigation aims to replace functions provided by aquatic resources lost during development. Post-restoration monitoring criteria known as performance standards are used to evaluate and verify restored wetland functionality and regulate mitigation credit release. Therefore, performance standards are vital in ascertaining wetland restoration techniques and mitigation processes. In Chapter …

An Action Research Evaluation Of An Online Inclusive Sport Peer Coach Training, Margaret Roberts Condon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Trained peer tutors are a proven pedagogical technique that can help eliminate barriers to inclusion in physical education and extracurricular sport, including a reported lack of training and experience of professionals. When adequately trained, peer tutors can encourage social interactions, provide constant feedback, and increase active learning and engagement. While recommendations for training peer tutors have been provided, there are currently no known studies examining a peer tutor training in an online format for middle and high school-aged students participating in an inclusive sport program.

Purpose: The purpose of this study was to evaluate the effectiveness of an …

Incentive Analysis Of Blockchain Technology, Rahul Reddy Annareddy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Blockchain technology was invented in the Bitcoin whitepaper released in 2008. Since then, several decentralized cryptocurrencies and applications have become mainstream. There has been an immense amount of engineering effort put into developing blockchain networks. Relatively few projects backed by blockchain technology have succeeded and maintained a large community of developers, users, and customers, while many popular projects with billions of dollars in funding and market capitalizations have turned out to be complete scams.

This thesis discusses the technological innovations introduced in the Bitcoin whitepaper and the following work of the last fifteen years that has enabled blockchain technology. A …

A Novel Computational Network Methodology For Discovery Of Biomarkers And Therapeutic Targets, Qing Ye

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung cancer has the second highest cancer incidence rate and the top cancer-related mortality worldwide. An estimate from the American Cancer Society shows that, in 2022, there will be about 236,740 lung cancer cases (117,910 men and 118,830 women) in the US. To date, there are no prognostic/predictive biomarkers to select chemotherapy, immunotherapy, and radiotherapy in individual non-small cell lung cancer (NSCLC) patients. There is an unmet clinical need to identify patients with early-stage NSCLC who are likely to develop recurrence and to predict their therapeutic responses. This dissertation developed a novel computational methodology for modeling molecular gene association networks …

Stationary Solutions And Stability Of Constant Equilibrium Solutions For A Chemotaxis System, Awatif Ramadan Zawali

Graduate Theses, Dissertations, and Problem Reports (ETD)

We consider a one-dimensional Chemotaxis model describing the dynamics of the cell density n, cell velocity u, chemoattractant c1, and chemorepellent c2, respectively. The model is related to angiogenesis in cancer cells. n represents the cell density of the vessel, the chemoattractant c1 is vascular endothelial growth factor (VEGF) and the chemorepellent c2 is the antiangiogenic drug. We study the existence of a nonconstant steady-state solution using the singular perturbation method. We also provide numerical examples of steady-state solutions for the fast system to illustrate the idea. For the dynamical problem in part II, we study the stability of constant …

Bacterial Contamination In Public Atac-Seq Data And Alignment-Free Detection Methods, Drake Michael Aesoph

Graduate Theses, Dissertations, and Problem Reports (ETD)

ATAC-seq is a new high-throughput sequencing technology for measuring chromatin accessibility within genomic samples. It can be used to discover new information about open regions, nucleosome positions, transcription factor binding sites, and DNA methylation. It is especially useful when combined with other next-generation sequencing techniques, such as RNA-seq. Unlike previous technologies, however, ATAC-seq is more sensitive to bacterial contamination, which is a well-known problem in cell cultures that can lead to incorrect experimental results. Previous studies have measured the contamination in public RNA-seq data and found that 5%- 10% of samples were contaminated. In this report, we investigate the prevalence …

A Novel Tool To Promote Surgical Team Awareness Of Nurse Anesthesia Students’ Level Of Training, Joseph Lewis Britz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Communication errors in operating room (OR) settings are a common and avoidable source of patient harm. Communication in OR settings is enhanced when all members of the surgical team have knowledge of the skills and proficiency of their fellow team members. Student registered nurse anesthetists (SRNAs) provide anesthesia under the supervision of a certified registered nurse anesthetist (CRNA) or physician anesthesiologist. SRNAs’ proficiency in delivering anesthesia can vary significantly depending on their level of training, which varies based on the progression of the student in their multi-year nurse anesthesia program. Methods: This quality improvement project implemented a standardized non-verbal …

Electronic Structure Of Early Transition Metal Complexes Supported By Pyridine Polypyrrolide Ligands, Dylan Connor Leary

Graduate Theses, Dissertations, and Problem Reports (ETD)

A thorough study of photoluminescent molecules involving the pyridine polypyrrole(ide) ligand platform has been conducted. A detailed analysis on speciation of the proligand H₂(^MesPDP^Ph) (H₂^MesPDP^Ph = 2,6-bis(5-mesityl-3-phenyl-1H-pyrrol-2-yl)-pyridine) and its dilithium salt Li₂(^MesPDP^Ph) revealed temperature- and solvent-dependent effects. These molecules, along with the hydrochloric acid adduct [H₃(^MesPDP^Ph)]Cl were found to exhibit short-lived photoluminescence in both tetrahydrofuran and benzene solution. These findings confirm the hypothesis that heavy-atom involvement is crucial for the favorable photophysical properties observed for the Zr(PDP)_{2 …}

Love At First Profile: An Experiment Exploring If Previously Incarcerated Individuals Are Less Desirable While Online Dating, Carina L. Perrone

Graduate Theses, Dissertations, and Problem Reports (ETD)

Incarceration is a rapidly increasing occurrence in the United States with more than 1.4 million people incarcerated and more than 2 million on some form of restricted confinement. While men are incarcerated at a much higher rate than women, women are still at a steady incline of incarceration as well. Also, people of color disproportionately make up a large number of those incarcerated while accounting for a small percentage of the general population. Previous research on people who have been incarcerated focuses on it affects education, employment, and marriage. Little research has attempted to explore how incarceration effects dating, a …