Digital Commons Network^™

Bayesian Adaptive Clinical Trial Design, Mengyi Lu

Dissertations and Theses (Open Access)

The landscape of drug development in oncology has changed from conventional chemotherapies to molecular targeted therapies and immunotherapies, which provide innovative therapeutic modalities for treating cancers. These novel therapeutic agents work through mechanisms that fundamentally differ from standard chemotherapeutic agents, making the conventional trial design paradigm inefficient and dysfunctional. Specifically, the focus of dose-finding trials has shifted from finding the maximum tolerated dose (MTD) to the optimal biological dose (OBD), defined as the dose that optimizes the risk–benefit tradeoff. How to accurately identify the OBD and its dosing schedule is of great importance to maximize efficacy and safety of targeted …

Infrastructure Development For Personalized Risk Prediction To Reduce Cardiovascular Disease In Childhood Cancer Survivors, Suman Shrestha

Dissertations and Theses (Open Access)

Although childhood cancer survivors have lengthy life expectancies, they run the risk of experiencing long-term health issues as a result of their treatment. The most frequent non-cancerous cause of morbidity and mortality for these survivors is cardiac disease. Radiation therapy (RT) has been linked in numerous cohort studies to a higher chance of developing a late cardiac disease in these survivors, and this risk rises with higher mean heart doses and increased RT exposure to larger cardiac volumes. Since, the heart is a heterogeneous organ made up of several distinct substructures, RT dose received by the entire heart does not …

Individual Differences In Lpp Amplitude And Theta Power Predict Cue-Induced Eating During A Cued Food Delivery Task, Kyla Gibney

Dissertations and Theses (Open Access)

Due to individual differences in the brain’s reward system, some individuals are more vulnerable than others to maladaptive, reward-seeking behaviors, such as substance use or compulsive eating. A body of research has demonstrated that individuals who attribute higher levels of incentive salience to reward-associated cues than to pleasant images (termed “C>P group” throughout) are more vulnerable to compulsive eating than those who attribute higher incentive salience to pleasant images than reward- associated cues (P>C group). Meanwhile, a separate body of research has demonstrated that cognitive control also regulates eating by enabling top-down attentional control. This dissertation aims to …

Risk-Factor Induced Changes In The Breast Microenvironment Facilitate Inflammatory Breast Cancer Progression And Lymphovascular Invasion, Wintana Balema, Wintana Balema

Dissertations and Theses (Open Access)

Inflammatory breast cancer (IBC) is a rapidly progressing, rare and highly lethal form of breast cancer. IBC is a clinical diagnosis, requiring >1/3 involvement on the affected breast and/or skin by erythema, and disease onset of < 6 months. The clinical symptoms of IBC vary in severity and presentation, these include redness, warmth, skin thickening and bruised or pink/purple discoloration appearance and skin changes such as peau d’orange. These skin symptoms are not attributed to inflammation, rather IBC is characterized by florid lymphovascular tumor emboli clogging dermal lymphatics. This leads to “classic” symptoms of breast swelling and skin edema or discoloration. To date, unique genomic drivers which differentiate IBC from non-IBC invasive breast cancers have not been identified highlighting a role for the microenvironment. Several epidemiological studies have unveiled subtype-specific risk factors associated with IBC that are known to alter the microenvironment. Obesity is an established risk factor for all subtypes of IBC. Never-breastfeeding increases risk for developing the most aggressive, triple-negative IBC. Further, never breastfeeding is associated with later clinical stage and worse outcomes. We worked to model these overlapping risk factors to understand microenvironment changes that may lead to the lymphatic change’s indicative of IBC.

First, we investigated the association of a “classic” triad of clinical IBC signs with overall survival among patients to demonstrate the most overt clinical findings of lymphatic involvement were impacting prognosis. We evaluated a triad of IBC signs, including swollen involved breast, nipple change, and diffuse skin change, using breast medical photographs from patients enrolled on a prospective IBC registry. We reported that the …

Genetic Analysis Of Rna Exosome Complex Cofactors, Luisa Orlando

Dissertations and Theses (Open Access)

The RNA exosome complex is known to process and/or degrade many classes of RNA, including mRNA, rRNA, tRNA and snRNA, through its 3’-to-5’ exoribonuclease catalytic activity. The RNA exosome complex comprises a 9-unit core (exo-9), with six proteins making up a PH-Ring barrel and three proteins making up a S1-KH cap. The RNA exosome complex exo-9 core is inactive by itself and requires different cofactors in the nucleus and cytoplasm to perform different localized functions. This exo-9 core can associate with one or two catalytic subunits, including Rrp44/Dis3 and Rrp6 in yeast and DIS3 or DIS3L and RRP6/EXOSC10 in humans. …

Concomitant Inhibition Of Flt3 And Mcl-1 In Flt3 Mutated Acute Myeloid Leukemia, Paul Panis

Dissertations and Theses (Open Access)

The MCL-1 inhibitor S63845 synergizes with the FLT3 inhibitor midostaurin for potent anti-leukemic effect in preclinical human models of FLT3-ITD mutated acute myeloid leukemia (AML). Acute Myeloid leukemia (AML) is a neoplastic blood disorder defined by a characteristically rapid growth rate and altered behavior of myeloid cells in the bone marrow. The FLT3 receptor is responsible for the upstream regulation of many key processes in hematopoietic cells. FLT3 internal tandem duplication (ITD) mutations are common in leukemia and have been observed in up to a third of newly diagnosed AML patients. FLT3-ITD have been implicated as a driver mutation partly …

Ankyrin Dependent Mitochondrial Function And Bioenergetics In The Heart, Janani Subramaniam, Janani Subramaniam

Dissertations and Theses (Open Access)

ANK2 mutations in patients are associated with numerous arrhythmias, cardiomyopathies, and other heart defects. In the heart, AnkB, the protein encoded by ANK2, clusters relevant ion channels and cell adhesion molecules in several important domains; however, its role at Mitochondria Associated ER/SR Membranes (MAMs) has yet to be investigated. MAMs are crucial to mitochondrial function and metabolism and are signaling hubs implicated in various cardiac pathologies. Among several functions, these sites mediate the direct transfer of calcium from the ER/SR to the mitochondria to modulate ATP synthesis. Given that mitochondrial function and energy production are paramount to cardiovascular heath, …

When Sexual Assault Becomes Incident To Military Service, Lauren C. Brady

Journal of Law and Policy

For seventy-two years, federal courts have barred military servicemembers who are survivors of sexual assault from recovery under the Federal Tort Claims Act (FTCA). The Feres doctrine, promulgated from the Supreme Court case Feres v. United States, became the foundation for federal courts’ decisions that sexual assault is incident to one’s service in the military. Courts’ over-deference to the military has enabled a system that turns a blind eye to perpetrators and abusive environments on bases. However, the Ninth Circuit recently turned the tide in FTCA cases, holding in Spletstoser v. Hyten that military sexual assault survivors should be permitted …

What Counts As ‘Racist Enough?’: A Clearer Standard For New Trials When Jurors Demonstrate Racial Bias, Priyadarshini Das

Journal of Law and Policy

The no-impeachment rule, Federal Rule of Evidence 606(b), necessitates that jurors keep their deliberations secret. However, in the 2017 Supreme Court case Peña-Rodriguez v. Colorado, the Court created a racial bias exception to the no-impeachment rule. This exception allows jurors to notify the court when “one or more jurors made statements exhibiting overt racial bias that cast serious doubt on the fairness and impartiality of the jury’s deliberations and resulting verdict.” This Note argues that this standard is too narrow because it fails to consider several situations of racial bias, like implicit bias. The ineffectiveness of this exception is demonstrated …

Weathering The Storm: Establishing Internally Displaced People’S Right To Affordable Housing In The Wake Of Natural Disasters, Raina Hasan

Journal of Law and Policy

In 2020, natural disasters caused more internal displacement than war; floods, storms, and wildfires caused thirty million new displacements globally, and 1.7 million in the U.S. alone. The data and history suggest that masses of people will be displaced every year and will face housing insecurity without any formal acknowledgement of their unique plight or a guarantee that internally displaced persons (“IDPs”) will have protected rights. This Note proposes that, considering the worsening climate crisis leading to more frequent and severe natural disasters, the U.S. should codify the rights of internally displaced people as laid out in the United Nations’ …

Protecting The ‘Unwanted’: How And Why We Should Defend Former Gang Members In Their Pursuit Of Asylum, Anjani P. Shah

Journal of Law and Policy

This Note discusses the flaws in the tripartite analysis to determine whether an asylum seeker satisfies the protected ground of “membership in a ‘particular social group’” (“PSG”). An applicant seeking a PSG determination must prove: (1) “immutability,” (2) “social distinction,” and (3) “particularity.” This Note argues that when PSG asylum claims are denied and appealed to the Board of Immigration Appeals (“BIA”), the BIA has incoherently tangled what is actually required in order to compel an affirmative PSG determination. One group of asylum seekers that has been significantly disadvantaged by this tripartite test is former gang members. This Note argues …

Hacking Copyright: Holding Cops Accountable For Abusing Youtube’S Copyright Filter System, Tyler Bloom

Journal of Law and Policy

This Note both explores the mechanisms and incentive structures that make “copyright hacking” possible and explains the legal system’s failure to provide recourse for victims of successful “copyright hacks” by police officers. Because the DMCA has failed to keep pace with the internet’s exponential growth, OSPs, such as YouTube, have developed filtering systems that can be exploited to “copyright hack” users and ultimately suppress their speech. A victim of “copyright hacking” by a police officer currently has no recourse; the doctrine of qualified immunity functionally precludes them from suing for violating their First Amendment rights. This Note proposes two possible …

Ice Transfers And The Detention Archipelago, Sabrina Balgamwalla

Journal of Law and Policy

This article examines transfers as an understudied but critical dimension of the immigration detention system. Transfers regularly take detainees in immigration custody from public to private facilities, across state lines, and beyond the jurisdiction of individual courts. Immigration and Customs Enforcement (“ICE”) has virtually unlimited authority to use transfers strategically to further agency goals of immigration enforcement. For individual detainees, transfers shape outcomes in their immigration cases. Noncitizens are regularly funneled into detention centers in legal jurisdictions generally hostile to claims for relief. Transfers also regularly send detainees to facilities in isolated, rural communities, where they are more likely to …

Unending Reform: Police Resistance To Consent Decrees And Federal Monitors, Finn Mayock

Journal of Law and Policy

The murder of George Floyd and the subsequent protests that engulfed the United States in 2020 reignited public attention towards the violent and discriminatory practices of police departments across the country. While methods of reforming these institutions were debated with new vigor, the federal courts have been quietly overseeing efforts to obtain constitutionally compliant policing in numerous cities for decades. Using legal tools such as consent decrees and monitors, the Department of Justice has enlisted the assistance of federal courts to ensure that police practices are in congruence with the Constitution. As pervasive police violence against black and brown people …

Clinical Outcomes Associated With Co-Infection Of Carbapenem-Resistant Enterobacterales And Other Multidrug-Resistant Organisms, Bekana K Tadese, Stacia M Desantis, Osaro Mgbere, Kayo Fujimoto, Charles Darkoh

Faculty, Staff and Student Publications

BACKGROUND: Infections with carbapenem-resistant Enterobacterales (CRE) are associated with increased risk of death. Polymicrobial infections with antimicrobial-resistance may add to the burden of clinical care and patients' clinical prognosis.

AIM: to examine the impact of CRE co-infection with other multi-drug resistant organisms (MDRO) on patient clinical outcomes.

STUDY DESIGN: A retrospective observational study was conducted to compare the clinical outcomes of CRE patients who were co-infected with carbapenem-resistant

RESULTS: A total of 224 CRPA and 209 MDRA co-infections with CRE were identified from 4,236 cases from 2015-2020. The overall 90-day all-cause mortality was 21.6% but increased to 35.0% and 33.5% …

Adverse Drug Events Related To Common Asthma Medications In Us Hospitalized Children, 2000-2016, Luyu Xie, Andrew Gelfand, Matthew S Mathew, Folefac D Atem, Nimisha Srikanth, George L Delclos, Sarah E Messiah

Faculty, Staff and Student Publications

BACKGROUND: The reduction in adverse drug events is a priority in healthcare. Medications are frequently prescribed for asthmatic children, but epidemiological trends of adverse drug events related to anti-asthmatic medications have not been described in hospitalized children.

OBJECTIVE: The objective of this study was to report incidence trends, risk factors, and healthcare utilization of adverse drug events related to anti-asthmatic medications by major drug classes in hospitalized children in the USA from 2000 to 2016.

METHODS: A population-based temporal analysis included those aged 0-20 years who were hospitalized with asthma from the 2000 to 2016 Kids Inpatient Database. Age-stratified weighted …

Design For A Cluster Randomized Controlled Trial To Evaluate The Effects Of The Catch Healthy Smiles School-Based Oral Health Promotion Intervention Among Elementary School Children, Ru-Jye Chuang, Courtney Byrd-Williams, Jose-Miguel Yamal, Kila Johnson, Steven Kelder, Suchitra Nelson, Dania Mofleh, Shreela V Sharma

Faculty, Staff and Student Publications

BACKGROUND: The top two oral diseases (tooth decay and gum disease) are preventable, yet dental caries is the most common childhood disease with 68% of children entering kindergarten having tooth decay. CATCH Healthy Smiles is a coordinated school health program to prevent cavities for students in kindergarten, 1st, and 2nd grade, and is based on the framework of Coordinated Approach to Child Health (CATCH), an evidence-based coordinated school health program. CATCH has undergone several cluster-randomized controlled trials (CRCT) demonstrating sustainable long-term effectiveness in incorporating the factors surrounding children, in improving eating and physical activity behaviors, and reductions in obesity prevalence …

A Qualitative Investigation Of The Barriers And Facilitators To Hepatitis C Virus (Hcv) Screening Among Individuals Experiencing Homelessness In Houston, Texas, Alane Celeste-Villalvir, J Michael Wilkerson, Christine Markham, Lourdes Rodriguez, Vanessa Schick

Faculty, Staff and Student Publications

BACKGROUND: Individuals experiencing homelessness may be at a higher risk for hepatitis C infection because many are vulnerable to risk factors related to HCV. Screening is the very first step in the HCV care continuum, but it remains unclear how to improve HCV screening among this hard-to-reach population. Thus, the present study investigated the barriers and facilitators to HCV screening from the perspective of individuals experiencing homelessness within a non-residential social service setting.

METHODS: Individuals experiencing homelessness (aged 18+) were approached while they were seeking services at two community-based organizations in Houston, Texas, during August 2020. Participants (

RESULTS: Participants …

Effective Short Text Classification Via The Fusion Of Hybrid Features For Iot Social Data, Xiong Luo, Zhijian Yu, Zhigang Zhao, Wenbing Zhao, Jenq-Haur Wang

Electrical and Computer Engineering Faculty Publications

Nowadays short texts can be widely found in various social data in relation to the 5G-enabled Internet of Things (IoT). Short text classification is a challenging task due to its sparsity and the lack of context. Previous studies mainly tackle these problems by enhancing the semantic information or the statistical information individually. However, the improvement achieved by a single type of information is limited, while fusing various information may help to improve the classification accuracy more effectively. To fuse various information for short text classification, this article proposes a feature fusion method that integrates the statistical feature and the comprehensive …

Bridging The Gaps Of Healthcare Inequity And Nurse Well-Being, Kevin Moore, Paulette Sepe, Maricon Dans

Group: American Nurses Credentialing Center (ANCC)

The American Nurses Credentialing Center's Pathway to Excellence® (PTE) and Pathway to Excellence in Long-term Care® programs provide a framework to assist healthcare organizations across the continuum in their pursuit of a positive practice environment. The Pathway standards address the recommendations from the National Academy of Medicine (NAM) report, The Future of Nursing 2020-2030: Charting a Path to Health Equity, released in 2021. Drafted during the height of the global pandemic, the report highlights healthcare disparities in communities and the risks to the well-being of healthcare workers, primarily nurses. This article aims to describe the alignment between the Pathway standards …

Analysis Of The Issue Of New Mexico Black Male Educators’ Underrepresentation In Education Within New Mexico, Robert Sims Jr.

Dissertations

Increasing the educational profession's racial, gender, and ethnic diversification ensures the intentionality and equity of having more Black male educators serve as role models in U.S. schools. There is a need to understand better the journey and experiences of Black male educators, wherefore greater grassroots recruitment and retention efforts can be implemented to support Black men and young Black males who may aspire to become educators. Research that captures the experiences of Black male youth and educators as they navigate teaching and learning in predominately White educational systems may promote lines of inquiry for further research and intentional dialogue for …

Shelf-Life Extension And Campylobacter Jejuni Inhibition By Application Of Zinc Oxide Nanoparticles In Chicken Fillets, Amina Elrais, Reyad Rabea, Wlaa Abdel Megid, Mona Abdallah, Walid Sobhy Arab

Mansoura Veterinary Medical Journal

Because of its unique physical and chemical features, zinc oxide can be considered a versatile material. Campylobacter jejuni was intentionally inoculated into broiler breast fillets, and the practical application of zinc oxide nanoparticles (ZnO NPs) suspension with varying concentrations (5 mM and 10 mM) with 3 different sizes (25 nm, 50 nm, and 75 nm) for each concentration was examined. The results showed that ZnO suspensions had a strong inhibitory effect on Campylobacter jejuni growth after 8 days in the refrigerator at 4°C. When compared to other concentrations of 5 mM, ZnO NPs, 10 mM demonstrated the largest reduction percentage …

Molecular Characterization Of Some Pathogenic Bacterial Strains And Hematobiochemical Profile In Barki Sheep With Diarrhea In Siwa Oasis, Amani A. Hafez, Mohamed T. Ragab, Marwa A. Fawzy, Adel M. El-Kattan, Ahmed A. Elsayed

Mansoura Veterinary Medical Journal

Objective: To explore the incidence of several bacterial enteropathogens in Barki sheep with diarrhea and their antimicrobial resistance (AMR) trends and their hematobiochemical alteration in Siwa Oasis.Design: Descriptive study.Animals: A total of 500 adult Barki sheep were allocated into two equal-sized groups: 250 Barki ewes with diarrhea and 250 normal sheep taken as the control group. 250 faecal samples were taken from sheep with diarrhea. The bacterial enteropathogens were extracted, identified biochemically and determined using polymerase chain reaction (PCR). The Kirby-Bauer Disk-Diffusion Method was used to determine the sensitivity of positive samples from each organism to ten antimicrobials. Blood samples …

Effect Of Protein Reduction With Indispensable Amino Acid Supplementation At Different Levels In Practical Diets Of Nile Tilapia (Oreochromis Niloticus) Fish., Sara Youssef, Shimaa Salem, Rania Mahmoud, Tarek Ibrahim

Mansoura Veterinary Medical Journal

Objective: To estimate the effect of reducing dietary protein levels in Nile tilapia (Oreochromis niloticus) with dietary supplementation of commercially-available synthetic amino acids at different levels on growth performance, whole-body composition, morphometric indices, and serum metabolites.Design: Randomized controlled experimental study.Animals: One hundred eighty male Nile tilapia fingerlings.Procedures: One hundred eighty male Nile tilapia fingerlings were equally distributed in twelve glass aquaria (15 fish per aquarium) and fed the formulated diets at 4-5% of the body weight. Every two weeks, tilapia were weighed and the amount of feed intake was adjusted according to the increase in the tilapia weight. Results: By …

Investigation Of Temperature, Solution Strength, And Applied Stress Effects On Cation Exchange Processes In Geosynthetic Clay Liners, Kurt Katzenberger

Master's Theses

A laboratory test program was conducted to investigate the effects of temperature, solution strength, and applied stress over increasing conditioning durations on cation exchange processes in sodium bentonite (Na-B) geosynthetic clay liners (GCLs). The test program was intended to determine if the variables of temperature, solution strength, and applied stress had beneficial or detrimental effects on the engineering behavior of Na-B GCLs in municipal solid waste (MSW) landfills and laboratory testing applications. Needlepunched-reinforced, double non-woven Na-B GCL specimens were conditioned in fluids of increasing ionic strength (DI water, 2 mM CaCl2, 50 mM CaCl2, and 200 mM CaCl2 representing control, …

Irreducible Representations From Group Actions On Trees, Charlie Liou

Master's Theses

We study the representations of the symmetric group $S_n$ found by acting on

labeled graphs and trees with $n$ vertices. Our main results provide

combinatorial interpretations that give the number of times the irreducible

representations associated with the integer partitions $(n)$ and $(1^n)$ appear

in the representations. We describe a new sign

reversing involution with fixed points that provide a combinatorial

interpretation for the number of times the irreducible associated with the

integer partition $(n-1, 1)$ appears in the representations.

The Relationships Between College And Career Readiness Assessments, Charlotte M. Bruner

All Dissertations

This study explored the effects of taking Advanced Placement (AP) courses on college and career readiness in a rural school district in the southeastern United States. I examined student performance data using American College Test (ACT) scores, Ready to Work (R2W) examination scores, and AP examination scores. The results of the study show that taking a single AP course leads to significant improvement on the ACT exam over a student who has not taken an AP courses and the optimal number of courses a student should take. The results of the study also show that taking an AP course leads …

The Importance Of Hand Motions For Communication And Interaction In Virtual Reality, Alex Adkins

All Dissertations

Virtual reality (VR) is a growing method of communication and play. Recent advances have enabled hand-tracking technologies for consumer VR headsets, allowing virtual hands to mimic a user's real hand movements in real-time. A growing number of users now utilize hand-tracking when using VR to manipulate objects or to create gestures when interacting with others. As VR grows as a tool and communication platform, it is important to understand how the rising prevalence of hand-tracking technology might affect users' experiences.

The goal of this dissertation is to investigate, through a series of experiments, how using hand motions in VR influences …

High-Performance Vlsi Architectures For Lattice-Based Cryptography, Weihang Tan

All Dissertations

Lattice-based cryptography is a cryptographic primitive built upon the hard problems on point lattices. Cryptosystems relying on lattice-based cryptography have attracted huge attention in the last decade since they have post-quantum-resistant security and the remarkable construction of the algorithm. In particular, homomorphic encryption (HE) and post-quantum cryptography (PQC) are the two main applications of lattice-based cryptography. Meanwhile, the efficient hardware implementations for these advanced cryptography schemes are demanding to achieve a high-performance implementation.

This dissertation aims to investigate the novel and high-performance very large-scale integration (VLSI) architectures for lattice-based cryptography, including the HE and PQC schemes. This dissertation first presents …

Measurement And Evaluation Of Roadway Geometry For Safety Analyses And Pavement Material Volume Estimation For Resurfacing And Rehabilitation Using Mobile Lidar And Imagery-Based Point Clouds, Leonildo Nelson Cassule

All Dissertations

Roadway safety is a multifaceted issue affected by several variables including geometric design features of the roadway, weather conditions, sight distance issues, user behavior, and pavement surface condition. In recent years, transportation agencies have demonstrated a growing interest in utilizing Light Detecting and Ranging (LiDAR) and other remote sensing technologies to enhance data collection productivity, safety, and facilitate the development of strategies to maintain and improve existing roadway infrastructure. Studies have shown that three-dimensional (3D) point clouds acquired using mobile LiDAR systems are highly accurate, dense, and have numerous applications in transportation. Point cloud data applications include extraction of roadway …