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2022

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Exploring Roles Of Mir-372-3p In Proliferation Of Hepatocellular Carcinoma Cells, Pannathon Thamjamrassri Jan 2022

Exploring Roles Of Mir-372-3p In Proliferation Of Hepatocellular Carcinoma Cells, Pannathon Thamjamrassri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC has a replicative immortality and sustained proliferation rate. In addition, cell cycle-related protein regulating proliferation in cancer are often found dysregulated, allowing cancer cells to proceed their proliferation uncontrollably. Recently, a small non-coding RNA, microRNA (miRNA), was found to play an important role in numerous biological functions. Specific miRNA may ameliorate or promote cancer progression through different target mRNA. MiR-372-3p has been explored in various cancers such as colon cancer, colorectal cancer, and glioma. However, its functions have been rarely studied in HCC, especially in the aspect …

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Effects Of Chitosan Oligosaccharide And Probiotics On Chronic Kidney Disease Rats, Weerapat Anegkamol Jan 2022

Effects Of Chitosan Oligosaccharide And Probiotics On Chronic Kidney Disease Rats, Weerapat Anegkamol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chronic kidney disease (CKD) patients suffer from the accumulation of toxic substances in their blood due to the loss of kidney function, which results in hyperphosphatemia. This condition contributes to hyperparathyroidism, leading to the development of chronic kidney disease-related mineral bone disorder (CKD-MBD). Additionally, CKD patients experience changes in their gut microbiota, disrupting epithelial tight junctions and allowing excessive absorption of dietary phosphate. In this study, we aimed to investigate the effects of various oligosaccharides and probiotics on the gut microbiota, intestinal barrier, hyperphosphatemia, and hyperparathyroidism in CKD rats. We isolated Lactobacillus and Bifidobacterium strains from healthy participants and tested …

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In Vivo Dosimetry Of 3d Gynecological Brachytherapy Using The Glass Dosimeter: A Phantom Study, Itsaraporn Konlak Jan 2022

In Vivo Dosimetry Of 3d Gynecological Brachytherapy Using The Glass Dosimeter: A Phantom Study, Itsaraporn Konlak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Brachytherapy can deliver high doses to the target while sparing healthy tissues due to its steep dose gradient property. However, treatment was only performed according to the dose calculated by a treatment planning system without verification of the dose due to the characteristics. Therefore, the aim of this study was to design the in-house phantom to evaluate the dosimetric differences of gynecological brachytherapy under clinical conditions between calculation by the treatment planning system and measurement by the RPLGDs. An in-house phantom consisting of the glass dosimeter holder and the holder of the applicator was created. This holder was designed to …

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Dosimetric Differences Between Scheduled And Adapted Plans Generated From Ethos Adaptive Radiotherapy For Patients With Prostate Cancer, Sarita Suvira Jan 2022

Dosimetric Differences Between Scheduled And Adapted Plans Generated From Ethos Adaptive Radiotherapy For Patients With Prostate Cancer, Sarita Suvira

Chulalongkorn University Theses and Dissertations (Chula ETD)

Prostate is one of the organs that can easily move or change during the treatment fractions. Adaptive radiotherapy can help to reduce the uncertainty of interfraction and decrease the side effects produced from the radiation given to the patients. The objective of this study was to provide evidence of the efficiency of adaptive radiotherapy for prostate cancer patients by investigating the dosimetric differences between the scheduled and adapted plans generated from Ethos. The treatment data of 100 fractions of prostate cancer patients who had previously been treated on Ethos daily adaptive radiotherapy were collected. The treatment data in each fraction …

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Accuracy In Classification Of Liver Lesion Ultrasound Using Artificial Intelligence, Sutthirak Tangruangkiat Jan 2022

Accuracy In Classification Of Liver Lesion Ultrasound Using Artificial Intelligence, Sutthirak Tangruangkiat

Chulalongkorn University Theses and Dissertations (Chula ETD)

B-mode ultrasound imaging is the standard method for hepatocellular carcinoma (HCC) screening. If a lesion has a unique appearance, a conventional detector can be applied. However, if the lesion shares its appearance with other lesion, a large training dataset is required, which may be unavailable. Therefore, a two-stage method is proposed. In the first stage, lesions are detected but not differentiated into any particular class. The detected lesions are then classified in the second stage using a conventional convolutional neural network (CNN). The aims of the dissertation are to design an artificial intelligent system model and to investigate the most …

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Accuracy Of Small-Field High Energy Photon Using Plastic Scintillation Detector In Heterogenous Media Compared With Model-Based Algorithm Calculation, Thanat Kaewsuksri Jan 2022

Accuracy Of Small-Field High Energy Photon Using Plastic Scintillation Detector In Heterogenous Media Compared With Model-Based Algorithm Calculation, Thanat Kaewsuksri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Some radiotherapy techniques such as stereotactic body radiotherapy (SBRT) has the challenges in small field dosimetry in heterogenous media. This study aims at evaluating the accuracy of W2 plastic scintillation detector (PSD) compared with the calculation from algorithms for small-field high energy photon in heterogenous media. The characteristics of W2-PSD were studied. The percentage depth dose (PDD) of 6 FFF and 10 FFF with various field sizes ranging from 1x1 to 4x4 cm2 were measured in solid water phantom with low-density inhomogeneities slabs of air (Styrofoam) and lung (cork) and high-density inhomogeneity slab of aluminum. The characteristics of W2 plastic …

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Comparing The Success Rate Of Pleurodesis With Thoracoscopic Talc Poudrage Combined With Indwelling Pleural Catheter Versus Thoracoscopic Talc Poudrage In Patient With Malignant Pleural Effusion, A Randomized, Non-Inferiority Clinical Trial, Jitanong Sootlek Jan 2022

Comparing The Success Rate Of Pleurodesis With Thoracoscopic Talc Poudrage Combined With Indwelling Pleural Catheter Versus Thoracoscopic Talc Poudrage In Patient With Malignant Pleural Effusion, A Randomized, Non-Inferiority Clinical Trial, Jitanong Sootlek

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Malignant pleural effusion (MPE) can cause dyspnea symptoms that greatly impact a patient's quality of life. Talc pleurodesis or indwelling pleural catheter (IPC) insertion are two treatment options that can prevent recurrent MPE, alleviate dyspnea, and improve quality of life. However, talc pleurodesis requires a lengthy hospital stay, while IPC insertion is associated with lower pleurodesis success rates. Due to limited hospital bed capacity, we have devised a practical approach to managing MPE by combining TTP and IPC. Objective: This study aims to evaluate the efficacy of combined Thoracoscopic talc poudrage (TTP) and IPC compared to TTP alone in …

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Comparison Of Extubation Success Between Prophylactic Helmet Niv And Facemask Niv In High Risk Postextubation Patients;A Randomized Controlled Trial, Napat Jirawat Jan 2022

Comparison Of Extubation Success Between Prophylactic Helmet Niv And Facemask Niv In High Risk Postextubation Patients;A Randomized Controlled Trial, Napat Jirawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Post-extubation respiratory failure is a common complication in planned extubated patients, which increases mortality, particularly in high-risk patients. Noninvasive ventilation (NIV) with a facemask effectively prevents post-extubation respiratory failure, but helmet NIV use immediately after extubation is still unproven. Objective: To compare the success rates of extubation with prophylactic helmet NIV and facemask NIV in the first 48 hours in patients at high risk of developing post-extubation respiratory failure. Methods: The study was a single-center randomized controlled trial. The data were analyzed for 114 patients at high risk of extubation failure between June 2022 and June 2023. Patients were …

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Development Of An Artificial Intelligence Model For Prediction Of Dry Weight In Chronic Hemodialysis Patients And Assessment Of Its Accuracy Compared To Standard Bioelectrical Impedance Analysis, Nataphut Boonvisuth Jan 2022

Development Of An Artificial Intelligence Model For Prediction Of Dry Weight In Chronic Hemodialysis Patients And Assessment Of Its Accuracy Compared To Standard Bioelectrical Impedance Analysis, Nataphut Boonvisuth

Chulalongkorn University Theses and Dissertations (Chula ETD)

Proper determination of dry weight (DW) is crucial for achieving positive outcomes in hemodialysis (HD) patients. However, the traditional clinical assessment of DW (C-DW) is often inaccurate. Recently, bioimpedance spectroscopy (BIS) analysis using a Body Composition Monitor (BCM) device has emerged as a gold standard method for determining DW (BCM-DW). Despite its accuracy, the high cost of the BCM device limits its accessibility. To overcome this challenge, the current study proposes a machine learning (ML) model, which is a part of artificial intelligence (AI), to assess DW using available clinical and laboratory parameters. Objective: To develop an ML model for …

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D-Lactic Acid Fermentation Platform From Oil Palm Trunk Sap By Sporolactobacillus Terrae Sbt-1, Naphatsawan Sukaiem Jan 2022

D-Lactic Acid Fermentation Platform From Oil Palm Trunk Sap By Sporolactobacillus Terrae Sbt-1, Naphatsawan Sukaiem

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lactic acid is an organic acid that contains two enantiomers, L- and D-lactic acid, and is considered the most potential monomer for many industrial products. Lactic acid has versatile applications in the pharmaceutical, food, textile, chemical, and leather industries moreover in poly-lactic acid (PLA) manufacturing. While L-lactic acid is well known in many commercial products and studies, only a few studies on D-lactic acid were found. Lactic acid can be produced either by microbial fermentation or chemical synthesis. Approximately 90 percent of the total lactic acid produced worldwide is via microbial fermentation which provides an optically pure L- or D-lactic …

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High-Pressure Study Of Hybrid Organic-Inorganic Perovskites And Double Perovskites, Ardimas - Jan 2022

High-Pressure Study Of Hybrid Organic-Inorganic Perovskites And Double Perovskites, Ardimas -

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hybrid and double perovskite have been of great attraction for optoelectronic devices. However, exploring a feasible method to enhance their optical abilities remains a considerable challenge. Here, the researcher reports the pressure-induced phase transition as an effective way to modify optoelectronic properties. The researcher successfully synthesized the hybrid perovskite (MAPbI3) and the double perovskite (Cs2TiBr6) by the inverse temperature crystallization (ITC) and solution method, respectively. the researcher studied the pressure dependence phase transition and photoluminescence (PL) by placing the sample into diamond anvil cells (DACs) through Raman spectroscopy. The first principles method was used to support the idea. The researcher …

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Improving Quality Of Cvd Graphene Grown On The Copper Foil By Physical Polishing Electropolishing And Thermal Annealing Pretreatment Processes, Methawut Sirisom Jan 2022

Improving Quality Of Cvd Graphene Grown On The Copper Foil By Physical Polishing Electropolishing And Thermal Annealing Pretreatment Processes, Methawut Sirisom

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study optimized the pretreatment processes (physical polishing (PP), electropolishing (EP), and thermal annealing) for high-quality graphene growth on thin copper (Cu) foils. PP using Brasso solvent was applied to smoothen the substrate surface, followed by EP with H3PO4 to reduce rolling lines and surface contamination. The EP process involved different H3PO4 concentrations (30-60%) and etching times (60-120 seconds). After thermal annealing at 860-940 ºC, graphene growth was performed using direct-liquid-injection chemical-vapor deposition with cyclohexane (C6H12) as the carbon precursor and nitrogen as the carrier gas. The optimized conditions involved PP and EP with 45% H3PO4 concentration and 90 seconds …

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Factors Influencing Quality Nursing Care At Hospitals In Indonesia, I Gede Juanamasta Jan 2022

Factors Influencing Quality Nursing Care At Hospitals In Indonesia, I Gede Juanamasta

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study investigated whether patient-to-nurse ratio, working hours, nurse competence, environment, nurse satisfaction, and turnover intention influence inpatient quality nursing care in Indonesian hospitals. Aiken’s model and empirical evidence were adapted to construct the framework. A cross-sectional design and multistage sampling were employed. Five hundred-fifty registered inpatient department nurses from June to October 2022. They were involved in completing the seven-part questionnaires, include a demographic questionnaire, nurse staffing measurement form, Good Nursing Care Scale, Nurse Competence Scale, Practice Environment Scale, McCloskey/Mueller Satisfaction Scale, and Anticipated Turnover Scale. All questionnaires had acceptable psychometric properties, which included content validity, construct validity, and …

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Knowledge, Attitudes, Behavior, And Expectation Of Thai Patients Toward Dental Treatment During Covid-19 Pandemic: An Online Survey, Paratcha Pingsuthiwong Jan 2022

Knowledge, Attitudes, Behavior, And Expectation Of Thai Patients Toward Dental Treatment During Covid-19 Pandemic: An Online Survey, Paratcha Pingsuthiwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aerosol-generating procedures with contaminated saliva may pose a risk of disease transmission during the COVID-19 pandemic. COVID-19 preventive measures in dental clinics have evolved in response to the pandemic situation. This research investigated the effect of this pandemic on Thai patients' knowledge, attitudes, and behavior toward dental treatment. The online survey was distributed in June 2022. There were 978 participants in the study. The results showed that most participants had accurate knowledge about the COVID-19 transmission route in dentistry. The mean and median level of concern in the following issues were: contracting COVID-19 in daily life (3.06 and 3.03), contracting …

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Effect Of Normal Saline In Different Concentration On Soft Tissue Healing Of Extraction Wound: A Clinical Study, Walailuk Kunthikarn Jan 2022

Effect Of Normal Saline In Different Concentration On Soft Tissue Healing Of Extraction Wound: A Clinical Study, Walailuk Kunthikarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sodium chloride solution (NaCl) is regarded as the most suitable and recommended medical irrigation, because of the nontoxic and isotonic properties. The previous in vitro study showed that NaCl solution induced migration and extracellular matrix excretion from human gingival fibroblast. However, there is no report concerning the effect of rinsing extraction wound with NaCl solution in clinical trial study. This research study is split mouth single-blind randomized controlled clinical trial to investigate if rinsing with 0.9% and 1.8% NaCl solution on extraction wound can promote soft tissue healing. The operation was performed in 60 socket sites. The patients, who had …

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The Effects Of Decellularized Extracellular Matrix Derived From Jagged1-Treated Human Dental Pulp Stem Cells On Biological Responses Of Stem Cells Isolated From Apical Papilla, Suphalak Phothichailert Jan 2022

The Effects Of Decellularized Extracellular Matrix Derived From Jagged1-Treated Human Dental Pulp Stem Cells On Biological Responses Of Stem Cells Isolated From Apical Papilla, Suphalak Phothichailert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: Indirect Jagged1 immobilization efficiently activates canonical Notch signaling in hDPSCs. This study aimed to investigate the characteristic of the Jagged1-treated hDPSCs-derived dECM and its biological activity on odonto/osteogenic differentiation SCAPs. Methods: Bioinformatic database of Jagged1-treated hDPSCs was analyzed by NetworkAnalyst. hDPSCs seeded on Jagged1 immobilized surface were maintained with N or OM followed by decellularization procedure, dECM-N or dECM-OM, respectively. SCAPs were reseeded on each dECM with either normal medium or OM. Cell viability was determined by MTT assay. Characteristics of dECMs and SCAPs were evaluated by SEM, EDX, immunofluorescent staining and alcian blue staining. A Multipotential differentiation assay. …

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Prediction Of Future Caries In Toddlers Via Salivary Microbiome: A 1-Year Longitudinal Study, Ratcha Raksakmanut Jan 2022

Prediction Of Future Caries In Toddlers Via Salivary Microbiome: A 1-Year Longitudinal Study, Ratcha Raksakmanut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dental caries in children is the most common chronic oral disease that could disturb their quality of life including their development. Early prevention is a key approach to reducing the prevalence of early childhood caries. However, a reliable caries predictor, as an essential tool for targeted prevention that is important to this approach, is still lacking for infants before caries onset. Therefore, we aimed to develop the caries risk prediction model based on the salivary microbiome of caries-free 1-year-old children to predict caries onset at 1-year follow-up. Using a nested case-control design within a prospective cohort study, 30 saliva samples, …

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Expression Of Superoxide Dismutase 3 (Sod3) During Orthodontic Tooth Movement In Rats, Phanchanit Jindarojanakul Jan 2022

Expression Of Superoxide Dismutase 3 (Sod3) During Orthodontic Tooth Movement In Rats, Phanchanit Jindarojanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hypoxia induces reactive oxygen species (ROS) production in periodontal tissues. Superoxide dismutase 3 (SOD3) is an enzyme protecting cells from ROS. This study investigated SOD3 expression and function during rat orthodontic tooth movement (OTM) and in hypoxia-exposed rat PDL cells. OTM of right maxillary first molars were performed in Sprague-Dawley rats for 1 and 14 days (n = 6 per group). SOD3 and HIF-1α expression were evaluated by immunohistochemistry. SOD3 effects on cell viability and proliferation, ROS production, and mRNA expression of Hif-1α, Rankl, and Opg in PDL cells and osteoclast differentiation were investigated under normoxia and hypoxia. SOD3 expression …

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The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study, Peeraya Punpeng Jan 2022

The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study, Peeraya Punpeng

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this in vitro study was to compare the remineralization efficiency among Nano-silver fluoride 400 ppm (NSF400), 38% Silver diamine fluoride (38% SDF) and 5% Sodium fluoride (5% NaF) on artificial dentine caries in permanent molar or premolar teeth. The teeth were sectioned to obtain 120 specimens (3 x 3 x 2 mm3). After artificial caries were created, the lesion depth (LD) was measured using Micro-computed tomography (Micro-CT) (n=15 specimens/group), and the surface microhardness (SMH) was measured using a Knoop microhardness tester (n=15 specimens/group). Subsequently, all specimens were randomly assigned to four groups: Group 1) NSF400, Group 2) …

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Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects, Jeerawit Sirakittiworapong Jan 2022

Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects, Jeerawit Sirakittiworapong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Scaffold plays a key role in the context of tissue engineering. It not only provides a structural support for cells, but also creates an appropriate milieu for recruited cells, enhancing the therapeutic effects of cell-based treatments, and enabling the controlled release of biological cues such as growth factors. Collagen is widely used scaffold material in tissue engineering, particularly in periodontal and bone regeneration. Other natural polymers, however, have been developed and can be useful. Therefore, in this study, we aim to investigate the ability of four different natural polymers including collagen, chitosan, silk fibroin, and silk fibroin/gelatin hydrogel in promoting …

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The Study Of Oxygenated Compounds For Oil Fingerprinting Application, Khairunisa Betariani Jan 2022

The Study Of Oxygenated Compounds For Oil Fingerprinting Application, Khairunisa Betariani

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oil spills have a large impact on the marine and coastal environments. The characterization of petroleum or its products spilled in the environment to its source rocks is an important tool to assist in the resolution of issues of environmental impact and legal responsibility. The composition and physical properties of spilled oils have changed during the weathering process. Petroleum biomarkers is a tool for defining the origin of each oil, which is unique for each type of oil. In general, petroleum biomarkers (i.e., hopane group) are widely used for oil fingerprinting by following the NORDTEST methodology. Besides the hopane group, …

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Application Of Core Annular Flow For Oil Transportation In Different Pipe Configurations Using Computational Fluid Dynamics, Cindy Dianita Jan 2022

Application Of Core Annular Flow For Oil Transportation In Different Pipe Configurations Using Computational Fluid Dynamics, Cindy Dianita

Chulalongkorn University Theses and Dissertations (Chula ETD)

The application of Core Annular Flow (CAF) has become an interesting solution in transporting heavy oil through pipeline because of its energy reduction and cost efficiency. Current study conducted a 3D computational fluid dynamic (CFD) to simulate CAF of oil-water in horizontal T- and Y-pipe junctions with two types of oil characteristic i.e., oil as Newtonian fluid and oil as non-Newtonian Carreau Fluid. The 2k factorial statistical experimental design was applied to investigate the effect of geometry on the flow performance. Eight cases were run with different diameter combinations and junction angle. The most attractive design was measured by the …

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Improving Chromatographic Analysis Of Phenolic Compounds, Tarika Lomcharoenwong Jan 2022

Improving Chromatographic Analysis Of Phenolic Compounds, Tarika Lomcharoenwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Phenolic compounds are important chemicals and are applied in many fields. Moreover, they are found as contaminants in the environment. This research aimed to improve the chromatographic analysis of phenolic compounds and was divided into two parts. The first part focused on improving the separation of a mixture containing eighteen phenols using gas chromatography with derivatized cyclodextrin stationary phases. Results showed that all three cyclodextrin-based stationary phases, with different ring sizes, improved the separation of the mixture in comparison to polysiloxane OV-1701 stationary phase. The best separation was obtained from the small-size alpha-cyclodextrin with a capillary column of 15-meter long …

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Preparation Of Cellulose Micro- And Nano Fibers From Bagasse Through Deep Eutectic Solvent System, Worapoj Phuckpetch Jan 2022

Preparation Of Cellulose Micro- And Nano Fibers From Bagasse Through Deep Eutectic Solvent System, Worapoj Phuckpetch

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to prepare the cellulose micro- and nanofibers (CMNFs) using green chemistry viewpoint. The CMNFs were fabricated from sugarcane bagasse (SCB) pulp through treatment with zinc chloride (ZnCl2) - lactic acid (LA) in deep eutectic solvent (ZnCl2-LA DES) followed by short time ultrasonication of the DES-treated fibers in water. Under the optimum condition, the SCB pulp at high solid loading of 6.25% was treated with ZnCl2-LA DES. Lactate functionalized CMNFs with 230-270 nm length and 15-16 nm width were resulted in more than 90% yield and up to 62.2% crystallinity. The results showed that ZnCl2-LA DES was a …

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Deuteration Of Organic Compounds By Hydrothermal Process, Nattasiri Phaisarn Jan 2022

Deuteration Of Organic Compounds By Hydrothermal Process, Nattasiri Phaisarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Deuterium-labeled compounds are in great demand in many applications, especially as reference standards for various analytical techniques. The objective of this study is to develop two complementary methods for deuterium labeling of organic compounds including the hydrogen-deuterium exchange (HDx) and halogen-deuterium exchange (XDx) reactions under hydrothermal conditions. For HDx, several aliphatic, alicyclic, aromatic, heterocyclic, and amino acid compounds were used as model substrates to determine the reactivity pattern and scope of the reaction. It was found that the HDx at the ortho- and para-Hs of phenolic compounds and a-position of amino acids as well as certain heteroaromatic compounds occurred efficiently …

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Stimulation Of Immune Response In Mice Using The Plant-Produced Sars-Cov-2 S1 Subunit Protein Linked To The Fc Region, Chalisa Panapitakkul Jan 2022

Stimulation Of Immune Response In Mice Using The Plant-Produced Sars-Cov-2 S1 Subunit Protein Linked To The Fc Region, Chalisa Panapitakkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 made a devastating impact worldwide, and virus management is challenging owing to a lack of specific therapies or affordable vaccines, especially in low-and middle-income countries. Hence a low-cost and efficient vaccine is necessary. In the present study, the immunogenicity of the plant-produced S1 subunit protein of SARS-CoV-2 was investigated in order to utilize it as a subunit vaccine. The SARS-CoV-2 S1 subunit protein was fused with the Fc region of human immunoglobulin (IgG1) and expressed in tobacco plants in species of Nicotiana benthamiana plants by agroinfiltration. The …

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Free Radical Scavengers From Dendrobium Virgineum, Pongsawat Panuthai Jan 2022

Free Radical Scavengers From Dendrobium Virgineum, Pongsawat Panuthai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Free radicals are unstable, highly reactive, molecules which can cause several degenerative diseases such as mutagenesis and carcinogenesis. This research aims to study the chemical constitutents of Dendrobium virgineum and their antioxidant activity in 3 different test models including DPPH radical scavenging assay, superoxide radical scavenging activity assay and oxygen radical absorbance capacity assay. Nine compounds were isolated and determined to be two new compounds named 2,8-dimethoxy-9,10-dihydro-4,5-phenanthrenediol and 2,5-dimethoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone, together with seven known compounds, which are 2-methoxy-9,10-dihydro-4,5-phenanthrenediol, gigantol, 5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone, p-coumaric acid, tristin, 2,5,7-trihydroxy-4-methoxy-9,10-dihydrophenanthrene and 9,10-dihydro-2,4,7-phenanthrenetriol. The result obtained from the three testing models revealed that 2,5,7-trihydroxy-4-methoxy-9,10-dihydrophenanthrene showed strongest antioxidant activity. …

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The Effect Of Extensive Reading On English Reading Comprehension Of Chinese Efl Students With Low And High Reading Self-Efficacy, Manman Dai Jan 2022

The Effect Of Extensive Reading On English Reading Comprehension Of Chinese Efl Students With Low And High Reading Self-Efficacy, Manman Dai

Chulalongkorn University Theses and Dissertations (Chula ETD)

English language teaching in rural Chinese high schools has not only been methodologically backward, but also impractical in content and approach, it led to distract student motivation, decrease language abilities, and even diminish reading improvement. With the emphasis on motivating students to read extensively, it might reduce these obstacles and challenges to promote an authentic reading intervention in a foreign language. This study investigated how English extensive reading improved reading comprehension and reading self-efficacy among Chinese EFL students for rural contexts in China. Fifty-four Chinese high school students participated in a twelve-week mixed-methods study. Quantitative data were collected through English …

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Innovation Process Of Amorphous Cellulose - Graphene Oxide Hybrid Structure For Water Treatment In A Shrimp Farm, Kongkiat Phuphantrakun Jan 2022

Innovation Process Of Amorphous Cellulose - Graphene Oxide Hybrid Structure For Water Treatment In A Shrimp Farm, Kongkiat Phuphantrakun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Amorphous cellulose-graphene oxide bead composites are popularly employed in water purification. However, the existing fabrication methods of amorphous cellulose (AC) and amorphous cellulose-graphene oxide (ACGO) beads are complicated with many chemical use, multi-step, time and energy-consuming. In this research, we proposed an efficient method for fabricating amorphous cellulose-graphene oxide (ACGO) beads using less chemical under a simple 2-step approach. The production process of AC and ACGO beads was successfully fabricated via sulfuric acid (H2SO4) gelatinization and regeneration using eucalyptus paper as a raw material. The cellulose gel was droplet-extruded into deionized (DI) water and transformed into a solid bead via …

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Process And Stakeholder Relations In The Development Of City Festival To Stimulate The Creative Economy : The Case Study Of Chiang Mai Blooms, Atikarn Arunchot Jan 2022

Process And Stakeholder Relations In The Development Of City Festival To Stimulate The Creative Economy : The Case Study Of Chiang Mai Blooms, Atikarn Arunchot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Festivals relate to the creative economy in diverse ways, in which collaboration and relationships of stakeholders in the festival development process are significant factors that lead to positive impact of the festival. The aims of this paper are to examine the development process of the Chiang Mai Blooms as a city festival, the relationship of the stakeholders involved in the festival to promote the creative economy, and the factors promoting collaboration among festival stakeholders to drive the creative economy. The qualitative data was collected by conducting interviews and using questionnaires, and the secondary data was gathered from the related news …

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