Digital Commons Network^™

Pharmacokinetic Study Of Intranasal Dexamethasone And Methylprednisolone Compared With Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study In Healthy Volunteers, Graciela Cárdenas, Raúl J. Bobes, Gladis Fragoso, Nicolas I. Pérez-Osorio, Marisela Hernández, Alejandro Espinosa, Agnes Fleury, José Flores, Juan Carlos Alvarenga, Juan Pedro Laclette

School of Medicine Publications

Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well as tachyphylaxis and systemic, undesirable side effects are the main limitations of peripheral delivery. Intranasal administration offers direct access to the brain as it bypasses the blood–brain barrier. The Mucosal Atomization Device is an optimal tool that can achieve rapid absorption into the CNS and the bloodstream across mucosal membranes. This study was designed to evaluate and compare the bioavailability of DXM and MEP after intranasal versus intravenous administration. Two open-label, balanced, randomized, two-treatment, …

A Lagrangian Particle Model With Nesting Capability And Its Application To The Modeling Of Plastics In The Gulf Of Mexico, Weiyuan Dong

LSU Master's Theses

In our study, we refined an offline three-dimensional (3D) Lagrangian model named the Larval TRANSport Lagrangian (LTRANS) model and applied it to the Gulf of Mexico (GOM). Previous research that applied the model within the Texas-Louisiana (TXLA) shelf domain, which released plastics to simulate their trajectories and fate, showed that more than 40% of simulated particles did not reach the land boundaries. Some of those particles were assumed to move out of the TXLA domain. In reality, these particles could also re-enter the TXLA domain due to processes such as tidal excursion, mesoscale eddies and inertial oscillation. However, the model …

Exploring Medical Marijuana Knowledge And Perceptions Among A Community-Based Sample, Lan'tejuana S. Cooper, Jullet Davis Weaver, Vanessa Crowther, Marisa Lewis

Florida Public Health Review

Exploring Medical Marijuana Knowledge and Perceptions among a Community-Based Sample

Abstract

Background: The increasing number of states legalizing marijuana suggests that a growing majority of adults now see marijuana as offering more benefits than risks. As use increases, the need to better understand user characteristics and the nature of their beliefs also increases. Purpose: This exploratory study investigates the knowledge and perceptions of medical marijuana among community-based individuals. We theorize that demographic characteristics, socioeconomic status, social network, health status, and knowledge about marijuana are associated with the number of conditions the person believes marijuana treats. Methods: The study utilizes a …

Optimal Design Of Microfluidic Devices To Generate Core-Shell Structures, Shaochen Wu

Mechanical Engineering and Materials Science Independent Study

Core-shell structures offer a wide range of uses in biology, chemistry, medicine, pharmaceutics, cosmetics, and industrial applications, such as the food processing industry, thanks to their effective encapsulation qualities. [1] We now have unparalleled control and flexibility over the creation of emulsion droplets by microfluidic devices. Due to the expertise needed to create and manage these technologies, this is still restricted to specialized laboratories. [1] This report will briefly introduce the application of core-shell structures, advantages, and challenges of microfluidic devices before, and talk about the improved device design which helps create and solidify successful core-shell structures with different sizes …

Advances On Composite Cathodes For Lithium-Sulfur Batteries, Xi-Yao Li, Chang-Xin Zhao, Bo-Quan Li, Jia-Qi Huang, Qiang Zhang

Journal of Electrochemistry

Lithium-sulfur (Li-S) batteries are deemed as high-promising next-generation energy storage technique due to their ultrahigh theoretical energy density, where the sulfur cathodes with high specific capacity guarantee the energy density advantage and directly determine the battery performances. After decades of exploration, the most promising sulfur cathodes are sulfur/carbon composite (S/C) cathodes and sulfurized polyacrylonitrile (SPAN) cathodes. In this manuscript, recent advances on S/C and SPAN cathodes in Li-S batteries are comprehensively reviewed. The electrochemical reaction circumstances on S/C and SPAN cathodes are firstly introduced and compared to reveal the working mechanisms of the two types of Li-S batteries. The S/C …

Survey Results And Analysis Of Food Education Of Urban Middle School Students In Cities, Wang Qiu-Yun

Food and Machinery

In order to understand the awareness of urban adolescents on healthy diet, nutrition knowledge, traditional food culture, and food safety, a food education survey was carried out in the Middle School Affiliated to the National University of Defense Technology of the Chinese People's Liberation Army. Based on 1 088 middle and high school students, the questionnaire was designed from four dimensions: food nutrition cognition, correct eating habit cultivation and safety knowledge, traditional diet and etiquette inheritance, food education knowledge cognition and attitude. The results show that urban Middle school students have a high degree of awareness of food nutrition knowledge, …

Laws And Prevention Methods Of Ground Cracks In Shallow Coal Seam Mining, Hou Enke, Xie Xiaoshen, Feng Dong, Chen Qiuji, Che Xiaoyang, Hou Pengfei

Coal Geology & Exploration

The large-scale and high-intensity mining of shallow coal seams in northern Shaanxi has induced serious ground collapse, resulting in land damage in large area, water and soil loss, and vegetation death, and thus leading to the epigenetic environment degradation. In order to understand the development law of ground collapse and fracture in shallow coal seam mining, clarify its mechanism, and put forward the appropriate treatment and restoration measures to realize the coordinated development of “coal-water-ecology”, Zhangjiamao mine field and Ningtiaota mine field in northern Shaanxi were taken as the study area. On this basis, the development law and control methods …

Long-Term Use Of An Ankle-Foot Orthosis Intervention In Patients With Peripheral Artery Disease Using The Integrated Promoting Action On Research Implementation In Health Services (I-Parihs) Framework, Ayisha Bashir, Danae Dinkel, Iraklis Pipinos, Paul Estabrooks, Jason Johanning, Sara A. Myers

Journal Articles

Background

Peripheral artery disease (PAD) is a cardiovascular disease that limits patients' walking ability. Persistent ankle-foot orthosis (AFO) use may increase the distance patients can walk as well as physical activity.

Purpose

The purpose of the study was to determine the implementation and patients' perspectives related to the use or disuse of the AFO intervention six months post-intervention. This study was guided by a semi-structured interview and survey based on the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) constructs.

Design

A convergent mixed methods design was used to evaluate participants' perceptions six months following a three-month AFO …

Bard Early College: Milestones, Looking Back, Ray Peterson

Early College Folio

The author, whose professional experience includes serving as the founding principal of the first Bard High School Early College, maps the milestones of that experience and others through decades of early college leadership. Focusing on anecdotes and personal stories, this essay gives voice and texture to discourse about early college then and now as well as students, teachers, and the future of Bard's High School Early College program.

Succession Process And Management Mode Of Land Reclamation In Open-Pit Coal Mine Areas Based On Vegetation Rehabilitation, Zhou Wei, Guan Yanjun

Coal Geology & Exploration

Rehabilitated vegetation plays an important role in energy exchange and ecological cycling, and its dynamic change can characterize the extensive details of the disturbance to and the restoration of ecosystem in coal mining areas. From the points of different disturbance states of vegetation in the coal mining area, such as the undisturbed state, the coal mining disturbance state, the restoration state and the post-restoration state, six succession scenarios of the rehabilitated vegetation in coal mining areas were analyzed, including the effective restoration to maturity, inefficient restoration to maturity, effective restoration followed by degradation, effective restoration to development, inefficient restoration to …

Evaluation On Potential Of Using Abandoned Mines For Pumped Storage In Nine Provinces Of Yellow River Basin, Bian Zhengfu, Zhu Chaobin, Zhou Yuejin, Xu Yunong

Coal Geology & Exploration

In view of the low utilization rate of closed mine resources and the increasing demand for power and energy storage in China, the pumped storage technology of abandoned mine is an effective means to realize the secondary development and utilization of resources and enhance the peak sheaving capacity of power grid. Based on the working principle and development status of pumped storage power plants using the abandoned mines, it was proposed to build the semi-underground and full-underground pumped storage power plants using the abandoned mines in the nine provinces of Yellow River Basin. By considering the influence factors of space, …

Preparation Of Coal-Series Solid-Waste-Based Green Filling Materials And Their Performance, Dong Meng, Li Jiangshan, Chen Xin, Jin Jiaxu, Lu Longzhao

Coal Geology & Exploration

The filling technology is an important part of green mining. The low-carbon environmental-friendly filling materials with low costs in research and development and reliable performance are critical for the development of filling technologies. The coal gangue (CG) and coal-series metakaolin (MK) were adopted as the raw materials to prepare coal-series solid-waste-base green filling materials, and the effect of the mixing proportion and alkali activator on the strength and fluidity of filling materials was discussed. In combination with the X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric (TG) analysis and scanning electron microscopy/energy dispersive x-ray spectroscopy (SEM-EDS) and other characterization measures, …

Shear Characteristics And Modified Coulomb Model Of Alfalfa Root-Loess Composite, Duan Zhao, Yuan Lin, Bi Yinli, Wang Kai, Wu Yanbin, Zhang Qing

Coal Geology & Exploration

Plant roots can significantly improve the strength of soil. In order to explore the enhancement effect of alfalfa root on the shear strength of loess, study was conducted based on the root-soil composites of alfalfa with a growth period of 60 d herein. Specifically, the parameters on shear strength of the alfalfa root-soil composite and the tensile strength of alfalfa root were obtained through the direct shear tests and root tensile tests. By observing the structure and characteristics of alfalfa root with an electronic magnifier, a modified Coulomb model of root-soil composite was established with the empirical formula. Meanwhile, the …

Discussion On Identification Standard Of Coal-Measure Graphite, Cao Daiyong, Wang Lu, Zhu Wenqing, Wu Guoqiang, Wei Yingchun, Ning Shuzheng, Wang Guixiang, Xiao Jincheng, Xu Xiang, Liu Kang

Coal Geology & Exploration

The identification and classification of coal-measure graphite are the precondition and basic work of mineral geological exploration, as well as resource exploitation and utilization. The preparation of identification standards of coal-measure graphite should follow the principles of science, systematicness, applicability and operability. Coal graphitization and coalification is a continuous progression plus jump process, and the characteristics of coal-measure graphite, including the step evolution of macromolecular structure and the heterogeneity of material composition, leads to the complexity of ore identification. In order to establish the scientific and practical identification standards, and from the study of metallogenic mechanism and the demand of …

Precise Magnetotelluric Single-Component Processing Technology And Detection Of Deep Disaster-Causing Water Body, Li Peitao, Wu Qiang, Li Zhuorong, Li Wenyu, Xie Jian, Wang Yuxi

Coal Geology & Exploration

In order to realize the fine detection of hydrogeological conditions by natural source single-component magnetotelluric technology, the problems of magnetotelluric signal acquisition and processing were systematically analyzed, and study was conducted for the response characteristics of underground water-rich area on magnetotelluric wave. Besides, water-richness index model was established according to the magnetotelluric sounding theory and analytic hierarchy process. Moreover, the corresponding relationship between waveform and lithology was fitted based on a large amount of experimental data, and the information on physical properties, such as the dielectric constant, elastic brittleness, density and porosity was extracted from the fractal dimension of waveform. …

Evolution Law Of Water Inflow In Full Life Cycle Of Working Face In Deep Buried Inner Mongolia-Shaanxi Mining Area, Liu Yang, Yang Jian, Zhou Jianjun

Coal Geology & Exploration

The deep buried Inner Mongolia-Shaanxi mining area was newly developed, where the hydrogeological characteristics under the disturbance of coal mining were still unclear. Various types of water damage problems had occurred in the process of infrastructure construction and production. Among them, no research was conducted for the variation characteristics of water inflow during and after mining in working face, which increased the difficulty in the arrangement of underground water drainage system and the work of water prevention and control. In order to find out the evolution law of water inflow in the full life cycle of working face before and …

Experimental Research On Mechanical Properties Of “Jacked Pipe-Frozen Soil” Composite Structure In Freeze-Sealing Pipe Roof Tunnel, Duan Yin, Rong Chuanxin, Cai Haibing, Long Wei

Coal Geology & Exploration

As the key project of Zhuhai Connecting Line of Hong Kong‒Zhuhai‒Macao Bridge, the underground excavation section of Gongbei Tunnel has applied the freeze-sealing pipe roof method for the first time. Combining the advantages of the pipe roof method and the artificial ground freezing method, this method could form a “jacked pipe-frozen soil curtain” composite support system on the tunnel section, so as to effectively achieve the dual goals of “bearing” and “water-stopping between pipes”, thereby ensuring that stability and safety during tunnel excavation. To obtain the temperature, deformation and mechanical properties of the “jacked pipe-frozen soil” composite structure, a set …

Experimental Study On High-Pressure Hydraulic Percussive Rotary Drilling Based On Single-Tooth Rock-Breaking Process, Dou Xuqian, Yao Ningping, Li Xiushan, Wang Li, Zhang Kai, Wei Hongchao

Coal Geology & Exploration

Aiming at the problem of low efficiency of hard rock drilling in crossing borehole in underground coal mine, the morphology of crushing pit formed by column tooth under the percussive load was analyzed based on the percussive rotary drilling mechanism and the main characteristics of Wassara high-pressure hydraulic impactor, and the crushing pit was divided into the four areas of disintegration area, compact area, crack area and elastic area. On this basis, process analysis was performed on the continuous tooth rock-breaking with large and small interval impact. Meanwhile, the technical parameters of high-pressure hydraulic percussive rotary drilling were discussed with …

Fault Diagnosis Of Hydraulic Power System For Coal Mine Tunnel Drilling Rig Based On T-S Fuzzy Fault Tree, Liu Ruojun, Zhang Youzhen, Yao Ke

Coal Geology & Exploration

In view of the problems of fuzzy logic relation between the elements of the system, the polymorphism of fault mode, and the difficulty in obtaining the fault probability as a result of the complication of the hydraulic power system for coal mine tunnel drilling rig, a fault diagnosis method of hydraulic power system for coal mine tunnel drilling rig based on Takagi-Sugeno (T-S) fuzzy tree was proposed to overcome the limitations of traditional fault tree in fault diagnosis and analysis of the complex electromechanical hydraulic equipment. The method could timely and accurately obtain the fault information of equipment, and to …

Comprehensive Recycling Utilization Technology Of Foundation Engineering Slurry, Xie Hui, Ye Jingliang, Chen Juan, Xue Man, Hu Huicong, Yang Xianyu, Cai Jihua

Coal Geology & Exploration

Foundation engineering slurry in the fields of underground continuous walls, horizontal directional drilling, shield, and pipe jacking has the characteristics of large amount of consumption and relatively single pollutant. With the implementation of various national environmental protection laws and regulations, the comprehensive treatment of slurries is particularly important. In this paper, a set of comprehensive recycling utilization technology of foundation engineering slurry was proposed. The technology of sand removal plus recycling of purified slurry and drilling cuttings can be adopted to the circulating slurry, and the technology of calcium removing, pH reducing, flocculation separation, pressure filtration and recycling of wastewater …

Table Of Contents, The Editors

Coal Geology & Exploration

No abstract provided.

Influence Of Thick Sandstone On Development Of Overburden Mining Fissures In Northern Shaanxi Coal Mining Area Of Yellow River Basin And Suggestions On Water-Preserved Coal Mining, Wang Shuangming, Wei Jiangbo, Song Shijie, Wang Shengquan, Sun Tao

Coal Geology & Exploration

The change of geological conditions of coal seam roof overburden and the development of mining fissures caused by coal mining activities are the direct causes of damage to the key underground aquifers, and also the root causes of ecological environment degradation in the mining area. As a typical geological condition, the thick sandstone developed in the overburden structure of the coal seam roof has an important impact on the development law of mining fissures in the overburden. Therefore, the influence of the thickness and location of different thick sandstones on the development morphology and height of overburden mining fractures was …

Experimental Study On Effect Of Soil Layer Reconstruction And Inoculation On Plant Root Hydraulic Lift In Open-Pit Coal Mine Dump, Bi Yinli, Gao Xuejiang, Ke Zengming, Xiao Li

Coal Geology & Exploration

Soil layer reconstruction of open-pit coal mine dump is of great significance for ecological reconstruction. In order to study the effect of inoculation of dark septate endophytes (DSE) on water utilization of corn root system under different reconstructed soil layer models, soil column simulating and culturing test was adopted, with DSE inoculation and control treatment set up under each of the four soil layer types, in a total of 8 groups. The results show that the roots of corn are the longest with the maximum density under the treatment with 20% loess, which are 3.2, 2.4 and 2.8 times that …

Real-Life Problems To Increase The Critical Analysis Thinking Among Novice Counselors In Humanistic Counseling Courses: Is It Effective?, Luthfita Cahya Irani, Suwarjo Suwarjo, Le Ngoc Ai Nhung

Jurnal Kajian Bimbingan dan Konseling

This study aims to determine the effectiveness of using real-life problems to improve novice counsellors' critical analytical thinking in humanistic counselling courses. The research method uses an experiment with a pretest-posttest control group design. The instrument used is a critical-analytical thinking scale. The research sample used a purposive sampling technique, which consisted of 84 students of the 2018 Guidance and Counseling UNY Study Program who took the Humanistic Counseling course. The samples were separated into experimental and control groups of 42 students. The pre-test and post-test data were analyzed using an independent sample t-test using SPSS Amos 25 software. The …

Establishment Of An In Vivo Streptozotocin-Induced Type 1 Diabetes Model Recapitulating Early Brain And Retinal Fibrosis, Kia Bourdot, Lucy Dawson, Igor Kuzin, Arturo Bravo Nuevo, Zeus Antonello

Cooper Rowan Medical Journal

INTRODUCTION: Diabetes has risen to one of the top American public health concerns. The hyperglycemic state of chronic diabetes leads to microvascular and macrovascular changes that predispose patients to delayed wound healing and organ fibrosis. The validation of models to specifically detect early, quantifiable fibrotic changes seen in the diabetic state is of fundamental importance for understanding the diabetic pathophysiology and exploring earlier management options. Here, we investigated if we could detect early signs of internal fibrosis in a streptozotocin (STZ) diabetic mouse model by quantifying α-SMA expression in various organs using flow cytometry.

METHODS: We used a low-dose STZ-induced …

Safety And Microbiological Activity Of Phage Therapy In Persons With Cystic Fibrosis Colonized With Pseudomonas Aeruginosa: Study Protocol For A Phase 1b/2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial, Pranita D Tamma, Maria Souli, Michael Billard, Joseph Campbell, Douglas Conrad, Damon W Ellison, Beth Evans, Scott R Evans, Kerryl E Greenwood-Quaintance, Andrey A Filippov, Holly S Geres, Toshimitsu Hamasaki, Lauren Komarow, Mikeljon P Nikolich, Thomas P Lodise, Seema U Nayak, Carmelle Norice-Tra, Robin Patel, David Pride, Janie Russell, Daria Van Tyne, Henry F Chambers, Vance G Fowlerjr, Robert T Schooley, Antibacterial Resistance Leadership Group

Faculty, Staff and Student Publications

BACKGROUND: Bacteriophages (phages) are a promising anti-infective option for human disease. Major gaps remain in understanding their potential utility.

METHODS: This is a randomized, placebo-controlled, double-blind study of a single dose of intravenous phage in approximately 72 clinically stable adult cystic fibrosis volunteers recruited from up to 20 US sites with Pseudomonas aeruginosa airway colonization. The single dose of phage consists of a mixture of four anti-pseudomonal phages. Six sentinel participants will be sequentially enrolled with dose escalation of the phage mixture by one log

DISCUSSION: This trial will investigate the activity of phages in reducing P. aeruginosa colony counts …

Preparation Of Highly-Cyclized Sulfurized Polyacrylonitrile For Lithium-Sulfur Batteries, Xuan Ji, Jia-Yu Wang, An-Bang Wang, Wei-Kun Wang, Ming Yao, Ya-Qin Huang

Journal of Electrochemistry

Sulfurized polyacrylonitrile (SPAN) is regarded as an attractive cathode candidate of lithium-sulfur (Li-S) batteries for its non-dissolution mechanism and effective alleviation of polysulfides shuttling issue in Li-S batteries, displaying high utilization of cathode active material, outstanding cycle stability and structural stability. However, the relation between cyclization degree and cycle stability of SPAN is still unveiled. In this work, SPAN-C-V composites were synthesized by co-introduction of CuSO₄ and zinc n-ethyl-n-phenyldithiocarbamate (ZDB) in the co-heating of sulfur and polyacrylonitrile. The co-introduction of CuSO₄ and ZDB reduced the cyclization reaction onset temperature of PAN while increased the C—C/C=C within SPAN-C-V, thus …

Carbon-Al Interface Effect On The Performance Of Ionic Liquid-Based Supercapacitor At 3 V And 65 OC, Zhen-Zhen Ye, Shu-Ting Zhang, Xin-Qi Chen, Jin Wang, Ying Jin, Chao-Jie Cui, Lei Zhang, Lu-Ming Qian, Gang Zhang, Wei-Zhong Qian

Journal of Electrochemistry

Ionic liquid (IL) electrolyte-based supercapacitors (SCs) have advantages of high operating voltage window, high energy density and nonflammability, as compared to conventional acetonitrile-based organic electrolyte SCs, and are typically suitable for the large-scale energy storage in the era of carbon neutrality full of renewable, but unstable electricity. However, current efforts were concentrated on the study with coin-cell type of IL-SCs, and less has been reported on the pouch type of IL-SCs for a long cycling time yet. To fabricate a reliable SC for the life time test or for the accelerated aging test under high temperature, one should concern the …

Application Of Artificial Intelligence To Lithium-Ion Battery Research And Development, Zhen-Wei Zhu, Jing-Yi Qiu, Li Wang, Gao-Ping Cao, Xiang-Ming He, Jing Wang, Hao Zhang

Journal of Electrochemistry

Lithium-ion batteries (LIBs) have become one of the best solutions to the energy storage issue in modern society. However, the battery materials and device development are both complex, and involve multivariable problems. Traditional trial-and-error approach, which relies on researchers to conduct experiments, has encountered bottlenecks in the improvement of the battery performance. Artificial intelligence (AI) is the most potential technology to deal with this issue due to its powerful high-speed and capabilities of processing massive data. In particular, the capability of machine learning (ML) algorithms in assessing multidimensional data variables and discovering patterns in the sets are expected to assist …

The Sexual And Gender-Based Violence Epidemic Meets The Covid-19 Pandemic: Survivors’ And Advocates’ Narratives In Egypt, Mozn Hassan, Helen Rizzo

Faculty Journal Articles

This research traces activism over the last 30 years against sexual and gender-based violence with a focus on survivors’ and advocates’ narratives in Egypt. We argue that several focusing events in Egypt and the support of transnational advocacy networks over the last decades have galvanised the efforts of activists and citizens of good will to mobilise around these issues. Egyptian feminist mobilisation during the pandemic brought to the public sphere the untold stories of the forms of violence that occurred through online and social media platforms. While social media and other online tools hold the promise of becoming “a new …