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Articles 991 - 1020 of 74197
Full-Text Articles in Entire DC Network
Associations Between Mental Health And Hiv Status Among Sexual Minority And Heterosexual Adolescents In Nigeria, Morenike Oluwatoyin Folayan, Olakunle Oginni, Olanrewaju Ibikunle Ibigbami, Uma Philip, Nserd Ntonoba Mfam, Chinedu Mbam, Amos Ganyam, Agada A Salem, Christopher Osuji, Cory Bradley, Joanne Lusher, Nadia Adjoa Sam-Agudu
Associations Between Mental Health And Hiv Status Among Sexual Minority And Heterosexual Adolescents In Nigeria, Morenike Oluwatoyin Folayan, Olakunle Oginni, Olanrewaju Ibikunle Ibigbami, Uma Philip, Nserd Ntonoba Mfam, Chinedu Mbam, Amos Ganyam, Agada A Salem, Christopher Osuji, Cory Bradley, Joanne Lusher, Nadia Adjoa Sam-Agudu
2020-Current year OA Pubs
BACKGROUND: We aimed to determine associations between the mental health status of adolescents by self-reported sexual identity; and to determine associations between the mental health status of sexual minority adolescents living with and without HIV.
METHODS: This cross-sectional study collected data from Nigerians aged 13-19 years old using an online survey. We collected information on dependent (sexual identity) and independent (presence of depressive symptoms, generalised anxiety disorder, suicidal attempt/ideation, HIV status) study variables. A multivariate regression model determined associations between the dependent and independent variables. A second multivariate regression model was developed to establish associations between HIV status among sexual …
Race In J. R. R. Tolkien’S The Lord Of The Rings And In Katherine Addison’S The Goblin Emperor, Robin A. Reid Dr.
Race In J. R. R. Tolkien’S The Lord Of The Rings And In Katherine Addison’S The Goblin Emperor, Robin A. Reid Dr.
Journal of Tolkien Research
Recent scholarship on how Tolkien's Orcs influenced popular fantasy agrees upon the spread of racist clichés and stereotypes. Dieter Petzold, in "'Oo, Those Awful Orcs!': Tolkien's Villains as Protagonists in Recent Fantasy Novels," analyzes how four novels attempt but fail to present orcs as focal and sympathetic characters. In Race and Popular Fantasy Literature, Helen Young argues that the influence Tolkien's Orcs had on fantasy literature, film, and games is that of structural racism in which "race [is] the conventional framework around which difference is built " (35). She acknowledges that critical reading of Tolkien's works can "provide background …
Reflection On Best Practices In Designing Online Middle Level Learning, Holly J. Thornton
Reflection On Best Practices In Designing Online Middle Level Learning, Holly J. Thornton
Current Issues in Middle Level Education
An increase in online learning during the pandemic has led to new thinking about online instruction that will last far beyond the pandemic. The hurried nature of instructional design as the pandemic shifted teaching and learning from the classroom to the computer may have neglected the need to design lessons using best practices online instead of focusing on content delivery and grading. Practices that are part of successful middle level education including cultivating depth of student understanding, developmental responsiveness, social emotional learning and differentiation to meet young adolescent student needs may have been neglected in pandemic online lesson design. This …
Examining Teaching And Learning Environments Among Kentucky Schools To Watch And Non-Schools To Watch Schools Using Tell Survey Data, Michael Dicicco, Ryan Alverson
Examining Teaching And Learning Environments Among Kentucky Schools To Watch And Non-Schools To Watch Schools Using Tell Survey Data, Michael Dicicco, Ryan Alverson
Current Issues in Middle Level Education
In 2017, the state of Kentucky distributed the Teaching, Empowerment, Leading, and Learning (TELL) survey to gain an understating of the learning environments in Kentucky schools. Many of the items on the TELL survey addressed key components of the School to Watch criteria and rubric. Researchers were interested in the teaching and learning conditions in Kentucky middle schools that contributed to successful school environments as defined by the Schools to Watch criteria, and to use results from the TELL survey to see what high scoring schools were doing well according to the teachers and principals that completed the survey. Researchers …
Celebrating 25 Years Of The National Association Of Professors Of Middle Level Education, Bridget K. Coleman, Nancy B. Ruppert
Celebrating 25 Years Of The National Association Of Professors Of Middle Level Education, Bridget K. Coleman, Nancy B. Ruppert
Current Issues in Middle Level Education
The National Association of Professors for Middle Level Education has been focused on middle grades education since 1997. This is an introduction for the CIMLE Journal in celebration of NAPOMLE's 25 anniversary in 2022.
Introduction, Amanda Wall
Introduction, Amanda Wall
Current Issues in Middle Level Education
Introduction
The articles in this issue of Current Issues in Middle Level Education include a celebration of the National Association of Professors of Middle Level Education, a report of a research study, and a summary of best practices.
Bridget Coleman and Nancy Ruppert are current and past presidents of the National Association of Professors of Middle Level Education (NAPOMLE). As this journal is the journal of NAPOMLE, we wanted to celebrate NAPOMLE’s 25th anniversary. Coleman and Ruppert reviewed several documents related to NAPOMLE’s history and mission; they also contacted several past leaders.
Michael DiCicco and Ryan Alverson contributed an …
Managing Artificial Intelligence Projects: Key Insights From An Ai Consulting Firm, Gregory Vial, Ann-Frances Cameron, Tanya Giannelia, Jinglu Jiang
Managing Artificial Intelligence Projects: Key Insights From An Ai Consulting Firm, Gregory Vial, Ann-Frances Cameron, Tanya Giannelia, Jinglu Jiang
Management and Accounting Faculty Scholarship
While organisations are increasingly interested in artificial intelligence (AI), many AI projects encounter significant issues or even fail. To gain a deeper understanding of the issues that arise during these projects and the practices that contribute to addressing them, we study the case of Consult, a North American AI consulting firm that helps organisations leverage the power of AI by providing custom solutions. The management of AI projects at Consult is a multi-method approach that draws on elements from traditional project management, agile practices, and AI workflow practices. While the combination of these elements enables Consult to be effective in …
Vol.50 N.22 December 22nd 2022, Voice Media Ventures
Vol.50 N.22 December 22nd 2022, Voice Media Ventures
Black Voice News
No abstract provided.
Bureaucratic Sorceries In The Third Policeman: Anthropological Perspectives On Magic & Officialdom, Alexandra Irimia
Bureaucratic Sorceries In The Third Policeman: Anthropological Perspectives On Magic & Officialdom, Alexandra Irimia
Languages and Cultures Publications
This article discusses The Third Policeman through the lens of a dialectic of enchantment and disenchantment that is firmly anchored in the history of anthropological discourse on bureaucracy (Malinowski, Lévi-Strauss, Tambiah, Herzfeld, Graeber, Jones). From this angle, Flann O’Brien’s novel is examined as an aesthetic illustration of an essentially anthropological argument: although bureaucracy has been described as an eminently rational form of social systematisation, regulation, and control (since Weber), it also functions, paradoxically, as a symbolic site for irrationality and supernatural occurrences, haunted by madness, mystery, and delusion. The novel is intriguing partly due to its nonchalant, humorous entwining of …
Realizing Molecular Machine Learning Through Communications For Biological Ai: Future Directions And Challenges, Sasitharan Balasubramaniam, Samitha Somathilaka, Sehee Sun, Adrian Ratwatte, Massimiliano Pierobon
Realizing Molecular Machine Learning Through Communications For Biological Ai: Future Directions And Challenges, Sasitharan Balasubramaniam, Samitha Somathilaka, Sehee Sun, Adrian Ratwatte, Massimiliano Pierobon
School of Computing: Faculty Publications
Artificial Intelligence (AI) and Machine Learning (ML) are weaving their way into the fabric of society, where they are playing a crucial role in numerous facets of our lives. As we witness the increased deployment of AI and ML in various types of devices, we benefit from their use into energy-efficient algorithms for low powered devices. In this paper, we investigate a scale and medium that is far smaller than conventional devices as we move towards molecular systems that can be utilized to perform machine learning functions, i.e., Molecular Machine Learning (MML). Fundamental to the operation of MML is the …
Prognostic Factors For Mortality Of Pediatric Burn Injury In A National Tertiary Referral Center, Heru Angkoso, Aria Kekalih
Prognostic Factors For Mortality Of Pediatric Burn Injury In A National Tertiary Referral Center, Heru Angkoso, Aria Kekalih
The New Ropanasuri Journal of Surgery
Introduction. In Indonesia, burn injuries cause about 195,000 deaths annually. Data from the Ministry of the Health Republic of Indonesia showed the incidence of burns predominated at 1-4 years old. The mortality of pediatric burn patients in a tertiary hospital was 37.26%. This study aimed to find an association between known and unknown prognostic factors of mortality in Indonesian-specific characteristics.
Method. A retrospective analytical study included all pediatric burns admitted to Dr. Cipto Mangunkusumo General Hospital (CMGH) from 1998 to 2010. Variables within a period of the first 72 hours of admission were the focus of interest and were extracted …
Quality Of Life And Its Associated Factors In Patients After Esophagectomy At A Single National Referral Center, Dogma H. Sirirui, Agi S. Putranto
Quality Of Life And Its Associated Factors In Patients After Esophagectomy At A Single National Referral Center, Dogma H. Sirirui, Agi S. Putranto
The New Ropanasuri Journal of Surgery
Introduction. Esophagectomy is the standard surgical treatment for resectable esophageal cancer patients. However, the success rate for this procedure was about 25–35% and was associated with a severe risk of postoperative complications. In addition, patients after esophagectomy have decreased their quality of life (QOL), but no research has been done in Indonesia. Therefore, this study was conducted to determine the quality of life after esophagectomy in Indonesia based on the patient population at Dr. Cipto Mangunkusumo General Hospital (CMGH).
Method. A retrospective study was conducted using quality–of–life instruments issued by the European Organization for Research and Treatment of Cancer (EORTC). …
Surgical Intervention For Endobronchial Tuberculosis With Total Bronchial Occlusion: A Case Report, Muhammad A. Putra, Matthew Billy, Radhyaksa Ardaya, Rut Hp Ekasiwi, Sari Rahmawati, Karel Hs Sumarsudi
Surgical Intervention For Endobronchial Tuberculosis With Total Bronchial Occlusion: A Case Report, Muhammad A. Putra, Matthew Billy, Radhyaksa Ardaya, Rut Hp Ekasiwi, Sari Rahmawati, Karel Hs Sumarsudi
The New Ropanasuri Journal of Surgery
Introduction. Endobronchial Tuberculosis (EBTB) is a specific TB form affecting the tracheobronchial tree with microbial and histopathological evidence. Early diagnosis is essential to provide timely treatment and prevent complications but also proves difficult due to the low positive rate of acid–fast bacilli (AFB) staining of sputum smears and non–specific clinical and radiological findings.
Case Illustration. We reported a 19–year–old man with a productive cough suspected of pulmonary tuberculosis, with a positive GeneXpert test and negative AFB smear. He received anti–tuberculosis drugs for six months. Although the symptoms initially seemed to improve, the patient complained of dyspnea during moderate activities in …
Potential Of Tumor Cell Seeding And Clinical Impact On Percutaneous Breast Biopsy Tracks: A Literature Review, I G.N. Gunawan Wibisana, Muhammad Mirwan
Potential Of Tumor Cell Seeding And Clinical Impact On Percutaneous Breast Biopsy Tracks: A Literature Review, I G.N. Gunawan Wibisana, Muhammad Mirwan
The New Ropanasuri Journal of Surgery
Introduction. Based on its effectiveness, a percutaneous breast biopsy was chosen because it has minimum side effects and fewer complications, does not distort the breast tissue architecture, and can be performed on an outpatient basis. However, the biopsy can damage the integrity of tumor cells, creating seeding at the site of the track made. Therefore, core biopsy is the method of choice for breast lesion sampling using a 14G needle that provides greater sensitivity. This study aims to explain whether the percutaneous biopsy track has the potential for the formation of tumor cell seeding and its clinical impact.
Methods …
Transplantation In Pediatrics Liver Failure Associated With Acute Hepatitis Of Unknown Etiology, Afid B. Putra, Agi S. Putranto, Muftah Risyaldi, Luthfian A. Nurachman
Transplantation In Pediatrics Liver Failure Associated With Acute Hepatitis Of Unknown Etiology, Afid B. Putra, Agi S. Putranto, Muftah Risyaldi, Luthfian A. Nurachman
The New Ropanasuri Journal of Surgery
Introduction. On 5th April 2022, some cases of severe acute hepatitis of unknown etiology in children were reported in the United Kingdom. Since then, the number has increased rapidly, with 650 probable cases identified worldwide. This review focuses on available information about managing acute liver failure (ALF) in pediatrics with acute hepatitis of unknown etiology through the perspective of hepatobiliary surgery.
Method. A literature review proceeded on some databases, namely PubMed and Google Scholar. Epidemiological data and technical policy were obtained from World Health Organization and some government institutions.
Results. Severe acute hepatitis can progressively develop into acute liver …
Comparison Ultrasound-Guided Handheld Vacuum Assisted Breast Biopsy And Core Biopsy In Breast Cancer, Anak Agung Ngurah Bagus Satya Sueningrat, Mendy Mendy
Comparison Ultrasound-Guided Handheld Vacuum Assisted Breast Biopsy And Core Biopsy In Breast Cancer, Anak Agung Ngurah Bagus Satya Sueningrat, Mendy Mendy
The New Ropanasuri Journal of Surgery
Introduction. Needle biopsy, including core needle biopsy (CNB) and vacuum-assisted breast biopsy (VABB) with or without radiological support) is the initial investigative method of choice for the preoperative diagnosis of breast lesions. Ultrasound-guided VABB (US-VABB) has become widely accepted because of its high accuracy. In this review, the diagnostic performance indices of CNB were compared with US-VABBB techniques.
Method. A literature search proceeded in online databases compiling studies from the last 20 years in the PubMed, EBSCOhost, ScienceDirect, and ProQuest databases. Eighteen eligible studies compared US-VABB and CNB for diagnostic accuracy. All studies were cohort retrospective. This literature search proceeded …
Use Of An Invertebrate Animal Model (Aplysia Californica) To Develop Novel Neural Interfaces For Neuromodulation, Junqi Zhuo, Jeffrey P. Gill, Michael W. Jenkins, Hillel J. Chiel
Use Of An Invertebrate Animal Model (Aplysia Californica) To Develop Novel Neural Interfaces For Neuromodulation, Junqi Zhuo, Jeffrey P. Gill, Michael W. Jenkins, Hillel J. Chiel
Faculty Scholarship
New tools for monitoring and manipulating neural activity have been developed with steadily improving functionality, specificity, and reliability, which are critical both for mapping neural circuits and treating neurological diseases. This review focuses on the use of an invertebrate animal, the marine mollusk Aplysia californica, in the development of novel neurotechniques. We review the basic physiological properties of Aplysia neurons and discuss the specific aspects that make it advantageous for developing novel neural interfaces: First, Aplysia nerves consist only of unmyelinated axons with various diameters, providing a particularly useful model of the unmyelinated C fibers in vertebrates that are known …
Aptamer Proteomics Of Serum Exosomes From Patients With Primary Raynaud's And Patients With Raynaud's At Risk Of Evolving Into Systemic Sclerosis, Sonsoles Piera-Velazquez, Simon T. Dillon, Xuesong Gu, Towia A. Libermann, Sergio A. Jimenez
Aptamer Proteomics Of Serum Exosomes From Patients With Primary Raynaud's And Patients With Raynaud's At Risk Of Evolving Into Systemic Sclerosis, Sonsoles Piera-Velazquez, Simon T. Dillon, Xuesong Gu, Towia A. Libermann, Sergio A. Jimenez
Department of Dermatology and Cutaneous Biology Faculty Papers
BACKGROUND: A major unmet need for Systemic Sclerosis (SSc) clinical management is the lack of biomarkers for the early diagnosis of patients with Raynaud's Phenomenon at high risk of evolving into SSc.
OBJECTIVE: To identify proteins contained within serum exosomes employing an aptamer proteomic analysis that may serve to reveal patients with Raynaud's Phenomenon at risk of developing SSc.
METHODS: Exosomes were isolated from serum samples from patients with Primary Raynaud's Phenomenon and from patients with Raynaud's Phenomenon harbouring serum antinuclear antibodies (ANA) who may be at high risk of evolving into SSc. The expression of 1,305 proteins was quantified …
Online Clinical Post-Conference, Face-To-Face Clinical Post-Conference: Effects On Critical Thinking In Associate Degree Nursing Students, Kristie A. Berkstresser
Online Clinical Post-Conference, Face-To-Face Clinical Post-Conference: Effects On Critical Thinking In Associate Degree Nursing Students, Kristie A. Berkstresser
Dissertations
Nurse educators, at every level of pre-licensure nursing education, are charged with developing critical thinking skills within their students. Post-clinical conference is one teaching strategy that nurse educators can employ to help promote the development of critical thinking skills in pre-licensure nursing students. However, traditional face-to-face post-clinical conference is marred with issues and concerns, as identified in the nursing education literature. An alternative to face-to-face post-clinical conference, asynchronous online learning environment, mitigates the issues and concerns associated with traditional post-clinical conference. Adult learning theory supports the use of asynchronous online learning environment. The asynchronous online learning environment promotes student-centered teaching …
Occupational Depression In Italy: Associations With Health, Economic, And Work-Life Characteristics, Renzo Bianchi, Caterina Fiorilli, Giacomo Angelini, Nicoletta Dozio, Carlo Palazzi, Gloria Palazzi, Benedetto Vitiello, Irvin Sam Schonfeld
Occupational Depression In Italy: Associations With Health, Economic, And Work-Life Characteristics, Renzo Bianchi, Caterina Fiorilli, Giacomo Angelini, Nicoletta Dozio, Carlo Palazzi, Gloria Palazzi, Benedetto Vitiello, Irvin Sam Schonfeld
Publications and Research
Background: The Occupational Depression Inventory (ODI) reflects a new approach to job-related distress centered on work-attributed depressive symptoms. The instrument was developed with reference to the characterization of major depression found in the DSM-5. The ODI has been validated in English, French, and Spanish. This study (a) investigated the psychometric and structural properties of the ODI’s Italian version and (b) inquired into the nomological network of occupational depression. Methods: A convenience sample of 963 employed individuals was recruited in Italy (69.9% female; mean age = 40.433). We notably relied on exploratory structural equation modeling bifactor analysis, common-practice …
The Correlation Between Premenopausal Estrogen And Estrogen Receptors In Breast Cancer, Ahmad Kurnia, Dedy Pratama, Muhammad Mirwan
The Correlation Between Premenopausal Estrogen And Estrogen Receptors In Breast Cancer, Ahmad Kurnia, Dedy Pratama, Muhammad Mirwan
The New Ropanasuri Journal of Surgery
Introduction. The correlation between the premenopausal estrogen hormone and estrogen receptors is unknown. The hormone estrogen has a risk factor for causing breast cancer. Meanwhile, the estrogen receptor plays a role in determining further treatment plans in breast cancer patients. Patients with high estrogen receptors have a better prognosis. If the premenopausal estrogen hormone can affect the estrogen-receptor, then the estrogen hormone can be modified to have a better prognosis.
Method. A cross-sectional study enrolled 32 subjects with complete data and was statistically analyzed to find the correlation between premenopausal estrogen hormone and estrogen-receptors.
Results. The estradiol ranged from 15.3 …
Prognostic Factors Of Myasthenia Gravis Remission After Thymectomy At National Referral Hospital In Indonesia, Suprayitno Wardoyo, Winda J. Layardi
Prognostic Factors Of Myasthenia Gravis Remission After Thymectomy At National Referral Hospital In Indonesia, Suprayitno Wardoyo, Winda J. Layardi
The New Ropanasuri Journal of Surgery
Introduction. Thymectomy is a recommended treatment for myasthenia gravis, enfacing the problem of a low remission rate. However, Indonesian-specific characteristics of myasthenia gravis are somehow different from those of well-developed countries. Thus, identifying prognostic factors influencing remission is required for patient selection to provide optimal preoperative issues.
Methods. A retrospective cohort proceeded in our tertiary hospital, enrolling those diagnosed with myasthenia gravis who underwent thymectomy for four years. Disease period modified Osserman classification, age, sex, preoperative plasmapheresis, preoperative steroid therapy, type of surgery, and thymic pathology were the variables of interest for three-year follow-up. In addition, these variables …
The Potential Of Liquid For Breast Cancer: A Review, Sonar Soni Panigoro, Clarissa Kezia Yuella -
The Potential Of Liquid For Breast Cancer: A Review, Sonar Soni Panigoro, Clarissa Kezia Yuella -
The New Ropanasuri Journal of Surgery
Introduction. Tissue biopsy is the current gold standard for cancer diagnosis, targeted treatment, and prognosis. However, biopsy is an invasive procedure that could result in postoperative bleeding, pain, and infection. Such limitations may now be resolved by the clinical technique known as liquid biopsy, which enables a better representation of disease status.
Method. This literature review was conducted through online databases (PubMed, Ascopubs, EuroPMC) using the following keywords: "liquid biopsy", "ctDNA", "CTC", "breast cancer", "pathogenesis of breast cancer", "tumor microenvironment”, “ctdna detection technologies”, "early diagnosis", "targeted therapy" ,"monitoring disease progression”, and "prognosis”. The literature search was conducted using the PRISMA …
Evaluation And Revision Of The Practice Environment Scale Of The Nursing Work Index For Acute Care Hospital Staff Nurses, Caitlin M. Campbell
Evaluation And Revision Of The Practice Environment Scale Of The Nursing Work Index For Acute Care Hospital Staff Nurses, Caitlin M. Campbell
Dissertations
The Practice Environment Scale of the Nursing Work Index (PES-NWI) is the most frequently used instrument for measuring the nursing work environment. The original PES-NWI obtained its items directly from the parent instrument, the Nursing Work Index, which was developed in the 1980s. However, potential value change among younger generations and vast historical, social, and technological transformations in the way healthcare is provided may have led to different factors that compose a favorable work environment for nurses working today.
Verge: A Collection Of Poems, Alexandria Machado
Verge: A Collection Of Poems, Alexandria Machado
Master’s Theses and Projects
No abstract provided.
“Cuando Crezca, Quiero Ser Fotógrafo”: Caminos De La Producción Audiovisual De Kamikia Kisêdjê, Rodrigo Lacerda, Ximena Flores Rojas, Tatiane Maíra Klein
“Cuando Crezca, Quiero Ser Fotógrafo”: Caminos De La Producción Audiovisual De Kamikia Kisêdjê, Rodrigo Lacerda, Ximena Flores Rojas, Tatiane Maíra Klein
Tipití: Journal of the Society for the Anthropology of Lowland South America
Entrevista con Kamikia Kisêdjê.
The Discrimination Of Self From Other As A Component Of Empathy., Charlotte Little, Elizaveta Solomonova, Maiya Jordan, Natalie Klein, Ben Jennings, Gunnar Schmidtmann, Héctor Leos, Ian Gold
The Discrimination Of Self From Other As A Component Of Empathy., Charlotte Little, Elizaveta Solomonova, Maiya Jordan, Natalie Klein, Ben Jennings, Gunnar Schmidtmann, Héctor Leos, Ian Gold
School of Health Professions
Despite the centrality of empathy in human social life, there is no widely agreed definition or characterization of the concept of empathy. A common thread in many of the proposed definitions, however, is that empathy presupposes the discrimination of self and other on the grounds that, to empathize with another individual, the mental state of the target individual must first be distinguished from the empathizer's own mental state. The purpose of this study is to investigate this proposal empirically. We employed a paradigm in which participants rated the emotional valence and degree of arousal of 93 facial expressions of mental …
The Density Of States Method In Yang-Mills Theories And First Order Phase Transitions, David Mason, Biagio Lucini, Maurizio Piai, Enrico Rinaldi, Davide Vadacchino
The Density Of States Method In Yang-Mills Theories And First Order Phase Transitions, David Mason, Biagio Lucini, Maurizio Piai, Enrico Rinaldi, Davide Vadacchino
School of Engineering, Computing and Mathematics
Extensions of the standard model that lead to first-order phase transitions in the early universe can produce a stochastic background of gravitational waves, which may be accessible to future detectors. Thermodynamic observables at the transition, such as the latent heat, can be determined by lattice simulations, and then used to predict the expected signatures in a given theory. In lattice calculations, the emergence of metastabilities in proximity of the phase transition may make the precise determination of these observables quite challenging, and may lead to large uncontrolled numerical errors. In this contribution, we discuss as a prototype lattice calculation the …
Myocardial Contractility Pattern Characterization In Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study With Contractix, El-Sayed H Ibrahim, Antonio Sosa, Sherry-Ann Brown, Dayeong An, Slade Klawikowski, John Baker, Carmen Bergom
Myocardial Contractility Pattern Characterization In Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study With Contractix, El-Sayed H Ibrahim, Antonio Sosa, Sherry-Ann Brown, Dayeong An, Slade Klawikowski, John Baker, Carmen Bergom
2020-Current year OA Pubs
Radiation therapy (RT) plays an integral role in treating thoracic cancers, despite the risk of radiation-induced cardiotoxicity. We hypothesize that our newly developed magnetic resonance imaging (MRI)-based contractility index (ContractiX) is a sensitive marker for early detection of RT-induced cardiotoxicity in a preclinical rat model of thoracic cancer RT. Adult salt-sensitive rats received image-guided heart RT and were imaged with MRI at 8 weeks and 10 weeks post-RT or sham. The MRI exam included cine and tagging sequences to measure left-ventricular ejection fraction (LVEF), mass, myocardial strain, and ContractiX. Furthermore, ventricular torsion, diastolic strain rate, and mechanical dyssynchrony were measured. …
Effectiveness Of Soluble Ctla-4-Fc In The Inhibition Of Bone Marrow T-Cell Activation In Context Of Indoleamine 2.3-Dioxygenase (Ido) And Cd4+Foxp3+ Treg Induction, Magdalena Massalska, Marzena Ciechomska, Ewa Kuca-Warnawin, Tomasz Burakowski, Anna Kornatka, Anna Radzikowska, Dariusz Pawlak, Barbara Muz, Adrianna Loniewska-Lwowska, Andrzej Palucha, Pawel Maldyk, Wlodzimierz Maslinski
Effectiveness Of Soluble Ctla-4-Fc In The Inhibition Of Bone Marrow T-Cell Activation In Context Of Indoleamine 2.3-Dioxygenase (Ido) And Cd4+Foxp3+ Treg Induction, Magdalena Massalska, Marzena Ciechomska, Ewa Kuca-Warnawin, Tomasz Burakowski, Anna Kornatka, Anna Radzikowska, Dariusz Pawlak, Barbara Muz, Adrianna Loniewska-Lwowska, Andrzej Palucha, Pawel Maldyk, Wlodzimierz Maslinski
2020-Current year OA Pubs
BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease with systemic inflammation finally resulting in damaged joints. One of the RA development models suggests bone marrow (BM) as a place of inflammation development further leading to disease progression. We aimed to investigate the potential of CTLA-4-Fc molecule in inducing tolerogenic milieu in BM measured as indoleamine 2,3-dioxygenase (IDO) expression, CD4
METHODS: Bone marrow mononuclear cells (BMMC) were stimulated by pro-inflammatory cytokines and CTLA-4-Fc. Next IDO expression, CD4
RESULTS: We found that CTLA-4-Fc and IFN-γ stimulation results in IDO production by BMMC. CTLA-4-Fc induced tryptophan catabolism can inhibit mitogen-induced CD4
CONCLUSION: …