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How To Manage The Initiation Of Apomorphine Therapy Without Antiemetic Pretreatment: A Review Of The Literature, Stuart H. Isaacson, Richard B. Dewey, Rajesh Pahwa, Daniel E. Kremens

Department of Neurology Faculty Papers

Introduction

Pretreatment with the antiemetic trimethobenzamide has been recommended practice in the United States (US) to address the risk of nausea and vomiting during initiation of apomorphine treatment. However, trimethobenzamide is no longer being manufactured in the US, and despite the recent update to the US prescribing information, there may be uncertainty regarding how to initiate apomorphine.

Methods

To better understand why antiemetic pretreatment was recommended and if it is necessary when initiating apomorphine therapy, we performed a literature review of subcutaneous apomorphine therapy initiation with and without antiemetic pretreatment in patients with PD.

Results

Three studies were identified as …

Spatiotemporal Distribution Change Of Online Reference During The Time Of Covid-19, Thom Gerrish, Ningning Nicole Kong

Libraries Faculty and Staff Scholarship and Research

The goal of this project was to identify the impact of the COVID-19 pandemic on the spatiotemporal distribution of the library’s online patrons, so that we could assess if the scheduled library reference hours are meeting the needs of the academic community. We collected each online reference patron’s location information via their IP address, as well as the timestamp of each online reference instance. The spatiotemporal distribution patterns were analyzed and compared before and after in-person instruction was suspended due to COVID-19 distance protocols and a closing of the campus in the 2020 spring semester. The results show that the …

Digital Financial Services And Strategic Financial Management: Financial Services Firms And Microenterprises In African Markets, Esi A. Elliot, Carmina Cavazos, Benjamin Ngugi

International Business and Entrepreneurship Faculty Publications

This study highlights the impact of digital financial services as enhancing the capacity of development goals as well as social sustainability. The selected emerging markets are Ghanaian financial service providers (FSP)s and microenterprise customers (CME)s, where we examine how “Ubuntu”, an African philosophy of humanism, legitimizes spaces for a more democratic, egalitarian, and ethical engagement of human beings. This study adopts a grounded theory methodology for investigation of the phenomena with a sample size of 70 relationship managers. The findings further existing sustainability literature pertaining to social sustainability and consumer wellbeing. We contribute to theory by presenting a psychological perspective …

Digital Habit Evidence, Andrew Guthrie Ferguson

Duke Law Journal

This Article explores how “habit evidence” will become a catalyst for a new form of digital proof based on the explosive growth of smart homes, smart cars, smart devices, and the Internet of Things. Habit evidence is the rule that certain sorts of semiautomatic, regularized responses to particular stimuli are trustworthy and thus admissible under the Federal Rules of Evidence (“FRE”) 406 “Habit; Routine Practice” and state equivalents.

While well established since the common law, “habit” has made only an inconsistent appearance in reported cases and has been underutilized in trial practice. But intriguingly, once applied to the world of …

Employed Algorithms: A Labor Model Of Corporate Liability For Ai, Mihailis E. Diamantis

Duke Law Journal

The workforce is digitizing. Leading consultancies estimate that algorithmic systems will replace 45 percent of human-held jobs by 2030. One feature that algorithms share with the human employees they are replacing is their capacity to cause harm. Even today, corporate algorithms discriminate against loan applicants, manipulate stock markets, collude over prices, and cause traffic deaths. Ordinarily, corporate employers would be responsible for these injuries, but the rules for assessing corporate liability arose at a time when only humans could act on behalf of corporations. Those rules apply awkwardly, if at all, to silicon. Some corporations have already discovered this legal …

Prescribing A Change To The Fda's Drug Labeling Rules After The 21st Century Cures Act, P. Sydney Engle

Duke Law Journal

Signed into law in 2016, the 21st Century Cures Act offers new hope to patients by empowering the FDA to expedite review of innovative, potentially lifesaving drugs. But these expedited approvals raise the risk that pivotal drug safety and efficacy data will not arise until after the drug is already on the market. The Cures Act failed to respond to two key aspects of shifting the discovery of safety and efficacy data to the postmarket phase. First, the Cures Act did not correspondingly enhance the FDA’s authority to require manufacturers to generate and disclose postmarket information. Second, it did not …

Journal Staff

Duke Law Journal

No abstract provided.

Association Of Chronic Kidney Disease With Prior Tinnitus: A Case-Control Study, Shih-Han Hung, Sudha Xirasagar Mbbs., Ph.D., Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin

Publications

This population-based, case−control study aims to explore the relationship between prior tinnitus and the occurrence of chronic kidney disease (CKD) using a nationwide, population-based cohort study. We used data from the Taiwan National Health Insurance Research Database to explore the association of CKD with tinnitus. We identified 15,314 patients aged ≥40 years old with a first-time diagnosis of CKD as the cases. We used propensity-scored matching to select 45,942 controls (1:3 ratio). We performed multivariate logistic regression to estimate the odds ratio (OR) of a prior tinnitus diagnosis among the CKD group vs. the control group. Analysis showed that 770 …

Sars-Cov-2 Detecting Rapid Metasurface-Based Sensor, Shobhit K. Patel, Jaymit Surve, Juveriya Parmar, Khaled Aliqab, Meshari Alsharari, Ammar Armghan

Department of Mechanical and Materials Engineering: Faculty Publications

We have proposed a novel approach to detect COVID-19 by detecting the ethyl butanoate which high volume ratio is present in the exhaled breath of a COVID-19 infected person. We have employed a refractive index sensor (RIS) with the help of a metasurface-based slotted T-shape perfect absorber that can detect ethyl butanoate present in exhaled breath of COVID-19 infected person with high sensitivity and in-process SARS-CoV-2. The optimized structure of the sensor is obtained by varying several structure parameters including structure length and thickness, slotted T-shape resonator length, width, and thickness. Sensor’s performance is evaluated based on numerous factors comprising …

The Importance Of The Lowly Skunk, Nicholas Gosling

UNH Today Archive

No abstract provided.

Quantification Of Phosphatidylethanol In Whole Blood And Dried Blood Spots By Lc-Ms/Ms, Elizabeth Yulianto

Student Theses

Phosphatidylethanol (PEth) is an alcohol biomarker that provides a longer window of detection than direct alcohol measurement or other common alcohol metabolites, like ethyl glucuronide. PEth has become useful in assessing drinking history, such as for alcohol-withdrawal treatment, organ transplant settings or prenatal alcohol exposure determination. A method was developed and validated to quantify PEth 16:0/18:1 and 16:0/18:2 in whole blood and dried blood spots (DBS) by liquid chromatography tandem mass spectrometry (LC-MS/MS). The whole blood method was applied to 149 samples from pregnant women, elucidating possible prenatal alcohol exposure. Fifty μL whole blood and 12.7 mm whole punches from …

Application Of Distributed Fiber-Optic Sensing For Pressure Predictions And Multiphase Flow Characterization, Gerald Kelechi Ekechukwu

LSU Doctoral Dissertations

In the oil and gas industry, distributed fiber optics sensing (DFOS) has the potential to revolutionize well and reservoir surveillance applications. Using fiber optic sensors is becoming increasingly common because of its chemically passive and non-magnetic interference properties, the possibility of flexible installations that could be behind the casing, on the tubing, or run on wireline, as well as the potential for densely distributed measurements along the entire length of the fiber. The main objectives of my research are to develop and demonstrate novel signal processing and machine learning computational techniques and workflows on DFOS data for a variety of …

Withdrawing Antipsychotics For Challenging Behaviours In Adults With Intellectual Disabilities: Experiences And Views Of Prescribers, G De Kuijper, J De Haan, S Deb, R Shankar

Peninsula Medical School

International current best practice recommends the discontinuation of antipsychotics for challenging behaviours in people with intellectual disabilities (ID), due to lack of evidence of efficacy and risks of harmful side-effects. In clinical practice, discontinuation may be difficult. The aim of this study was to gain insight into prescribers’ practice by investigating their experiences with the discontinuation of long-term antipsychotics for challenging behaviour. From professionals’ associations thirty-four registered ID physicians, psychiatrists and specialist mental healthcare nurses were recruited who completed an online questionnaire in this survey–study. Almost all participants had attempted to deprescribe antipsychotics for their patients with ID. Sixty-five percent …

The Challenges For Private Competition Law Enforcement Concerning Anticompetitive Conducts In Digital Markets, Jeanne Mouton

Yearbook of Antitrust and Regulatory Studies

The paper reviews literature on theories of harm in digital markets, and the specific difficulties in quantifying the damage in private enforcement of competition law. The development of a tentative case-law on private enforcement in digital markets in the European Union is studied next, in comparison to the US antitrust practice, differentiating between businesses or consumers filing damages claims. Finally, the paper raises the specific issues posed by the digital economy for competition law claims for damages, and explores the idea of extending the presumption of harm also to abuse of dominance in digital markets, as well as making private …

Why Do Competition Authorities Need Artificial Intelligence?, Isabella Lorenzoni

Yearbook of Antitrust and Regulatory Studies

Recent technological developments are transforming the way antitrust is enforced as well as the way market players are infringing competition law. As a result, enforcers are starting to equip themselves with sophisticated digital investigation tools. This paper explores this interest in building an Artificial Intelligence (AI) arsenal for the fight against algorithmic infringements. What are the key factors motivating regulators to develop their own technological tools to enforce competition law? Building on interviews with a number of competition authorities, this paper finds that changes in digital markets, the need for enforcers to reverseengineer companies’ algorithms in order to better understand …

Competition Law Enforcement In Ukraine: Challenges From On-Line Giants, Anzhelika Gerasymenko, Nataliia Mazaraki

Yearbook of Antitrust and Regulatory Studies

Competition law, economics and policy are facing a regulatory metamorphosis due to the rise of the digital economy. US, China and EU jurisdictions have announced and partially introduced systemic changes to their competition law frameworks to keep pace with technological developments. The Antimonopoly Committee of Ukraine is following the principle of ‘three monkeys’, it sees no on-line platforms, hears no on-line platforms, speaks of no on-line platforms, so nothing has been undertaken or even announced. The paper is twofold. Firstly, it analyses the economic background and features of the digital economy and shows why the available instruments of competition enforcement …

Section 19a Gwb As The German ‘Lex Gafa’ – Lighthouse Project Or Superfluous National Solo Run?, Tabea Bauermeister

Yearbook of Antitrust and Regulatory Studies

As the European Union kept on struggling with its Digital Markets Act, Germany forged ahead and implemented its own ‘Lex GAFA’ in early 2021. The paper will introduce this new Section 19a and explain its inner workings. Furthermore, Section 19a will be compared to classic Article 102 TFEU-procedure and contrasted with the DMA. Thereby, the paper will present the advantages and disadvantages of Section 19a in comparison to existing and future European law to assess whether Section 19a is in fact the lighthouse project it was presented to be – or rather a superfluous national solo run.

The Digital Markets Act Between The Eu Economic Constitutionalism And The Eu Competition Policy, Claudia Massa

Yearbook of Antitrust and Regulatory Studies

Given that a lot has already been written by legal scholars on the practical implications that the entry into force of the Digital Markets Act will have, the present article intends to bring the discussion back to the theoretical level, trying to find out where the roots of this proposed regulation lie, with an analysis of the context in which it falls, the EU principles and values upon which it is based, the objectives it intends to pursue, and the legal-economic theories behind it.

Gateways To The Internet Ecosystem – Enabling And Discovery Tools In The Age Of Global Online Platforms, Judit Firniksz, Borbála Tünde Dömötörfy, Péter Mezei

Yearbook of Antitrust and Regulatory Studies

The Google Shopping case has provided significant lessons that reach beyond antitrust enforcement. ‘Enabling and discovery tools’ create a layer that serves as a gateway to the Internet ecosystem. Therefore, on the one hand, they play a key role in ensuring the openness of the Internet ecosystem, and on the other hand, they exercise a primary influence on consumer experiences and their cognitive processes, which in turn determine online consumer transactions. Enabling and discovery tools, such as adopting design methods based on applied behavioural sciences (for example: user experience design (UX) and user interface design (UI)), create global challenges at …

The Housekeeping Of The Court Of Justice: The Ne Bis In Idem Principle And The Territorial Scope Of Nca Decisions Case Comment To The Nordzucker Judgment Of The Court Of Justice Of 22 March 2022, Case C-151/20, Kamil Dobosz

Yearbook of Antitrust and Regulatory Studies

The case commentary examines the recent ruling of the Court of Justice in the Nordzucker case. This judgment is important not only for the new approach to the ne bis in idem principle in competition law (which was first established in the Bpost case, issued the same day), but also for the clarification of the concept of “idem” with respect to the territorial effects of the infringement on the territories of two member states. The judgment thus provides guidance for the extraterritorial application of EU competition law.

Maciej Bernatt, Populism And Antitrust: The Illiberal Influence Of Populist Government On The Competition Law System, Cambridge University Press, 2022, 253 P., Baskaran Balasingham

Yearbook of Antitrust and Regulatory Studies

No abstract provided.

A Remembrance And Reflection On Dwain Ford's Teaching Philosophy, Desmond Hartwell Murray

Faculty Publications

No abstract provided.

Relationship Of Cognition And Alzheimer’S Disease With Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap And Mendelian Randomisation Analysis, Emmanuel O. Adewuyi, Eleanor K. O’Brien, Tenielle Porter, Simon M. Laws

Research outputs 2022 to 2026

Emerging observational evidence suggests links between cognitive impairment and a range of gastrointestinal tract (GIT) disorders; however, the mechanisms underlying their relationships remain unclear. Leveraging large-scale genome-wide association studies’ summary statistics, we comprehensively assessed genetic overlap and potential causality of cognitive traits and Alzheimer’s disease (AD) with several GIT disorders. We demonstrate a strong and highly significant inverse global genetic correlation between cognitive traits and GIT disorders — peptic ulcer disease (PUD), gastritis-duodenitis, diverticulosis, irritable bowel syndrome, and gastroesophageal reflux disease (GERD), but not inflammatory bowel disease (IBD). Further analysis detects 35 significant (p < 4.37 × 10 ^{− 5}) bivariate local genetic …

Taking The Biscuit: Defining Excessive Quantities Of Free Refreshments In A Healthcare Library, Andrew Tabner, Stuart G. Spicer, Kerryn Husk, Holly Blake, Caroline White, Suzanne Toft, Graham Johnson

Peninsula Medical School

Evidence suggests that complementary hot drinks and biscuits benefit an overworked and highly stressed healthcare workforce. But when signage in healthcare libraries asks patrons not to consume “excessive” quantities of free hot drinks and biscuits, how much is too much? Tabner and colleagues explore this resource allocation conundrumAs the festive season approaches, temperatures plummet, days shorten, and healthcare workers see glimmers of time off around the holidays, some might consider the provision of unlimited free hot drinks and biscuits a welcome token of appreciation; this is particularly the case for National Health Service staff, who are often felt to be …

Stress, Sleep, And Exercise Habits Among Extension Employees During The Covid-19 Pandemic, Jenna Anding, Miquela Smith, Scott Cummings

Journal of Extension

We compared perceived stress among 804 Extension employees during the initial months of the COVID-19 pandemic and again six months later. Work expectations, sleep and exercise habits were assessed. More than 46% of those responding believe work expectations are “much” or “moderately more” since the pandemic began. Nearly 60% report moderate levels of stress and 54% were sleeping less. Of those who were physically active (n=677) before the pandemic, 39% were exercising less. Because stress, sleep, and physical activity affect health, supervisors should recognize the impact the pandemic has on employees, and encourage the use of available resources to promote …

An Exploration Of Service Needs And Preferences Of Dementia Caregivers In Kentucky, Heehyul Moon, Sunshine Rote, Allison Kacmar, Amy Kostelic, Bari Lewis

Journal of Extension

As Americans live longer, the prevalence of Alzheimer’s disease and related dementias will increase. Caregivers are critical to the care and life quality of people with dementia. Yet, dementia caregivers are at increased risk for health issues, social isolation, and financial challenges. To help educators with the University of Kentucky Cooperative Extension Service work with their local Alzheimer’s Association and the University of Louisville to better support dementia families, we explored caregiver needs and service utilization using an online survey. Our findings highlighted the need for counseling/support, care management skills, resource education, self-care strategies, and legal services. Extension Service Educators …

Connecting Diverse Communities Through A 4-H Urban-Rural Experience, Laurie Murrah-Hanson, Brittani Lee, Pamela Bloch

Journal of Extension

Misconceptions regarding agricultural careers are exacerbated by increasing urbanization and are one of many differences in perspective between urban and rural communities. The One Georgia 4-H Urban-Rural Experience addresses this divide through a statewide youth exchange focusing on the agricultural sector. The program includes a multifaceted look at agricultural careers through visits to urban and rural communities. Focus group evaluations revealed the impact on youth through exposure to new careers, increased understanding of the diversity of agriculture, awareness of the interconnected nature of urban and rural communities, and a sense of belonging to a diverse group of youth.

New Mexico 4-H Online Horse Bowl Tournament, Jason L. Turner, Ryan W. Craig, Talisha L. Valdez, Halee M. Prather, Zane E. Webster, Sara K. Marta, Mindy G. Turner

Journal of Extension

Under COVID-19 public health order constraints, Extension professionals used readily available technology (e.g., Google Forms, Zoom, Facebook Live, and QuizBowl Pro) to conduct a traditional 4-H quiz bowl contest entirely in a virtual setting as an innovative means of offering positive youth development in a structured environment when most New Mexicans were homebound and unable to travel. Participation in the virtual contest was substantially greater than similar in-person contests in the preceding five-year period, and youth reported an increase in equine knowledge as well as life skill development.

Challenges Experienced By Aquaponic Hobbyists, Producers, And Educators, D Allen Pattillo, David J. Cline, Janelle V. Hager, Luke A. Roy, Terrill R. Hanson

Journal of Extension

We used an online survey to document challenges experienced by aquaponic hobbyists (n = 81), producers (n = 117), and educators (n = 75). Responses were distilled into the following categories: 1) operations and management; 2) facilities, location, and system design; 3) knowledge and educational resources; 4) funding; 5) economic viability; 6) plant culture; 7) marketing and distribution; 8) fish culture; 9) human factors; 10) regulations and certifications. Training and research in these areas are needed to advance the aquaponics industry.

Is There An Economic Advantage To Planting Diverse Summer Annual Forage Mixtures?, Kelly Mercier, Chris Teutsch, Ray Smith, Kenny Burdine, Edwin Ritchey, Eric Vanzant

Journal of Extension

This study examined economic implications of planting summer annual mixtures of grasses, legumes, and forbs at varying nitrogen rates. No differences in yield occurred between the three mixtures, indicating that mixtures with lowest seed cost will be most economical. Applying N resulted in yield increases of 12.26 lb DM per lb N applied. Although yield responses to N were positive, sensitivity analyses showed that applying N resulted in positive net returns only when hay prices were high and N prices were low. When utilization rates are accounted for, enterprise budgets determined grazing to be 18% cheaper to implement than haying.