Digital Commons Network^™

Treating Triple Negative Breast Cancer With Targeted Nano-Therapy, Mikayla Bridges

Mechanical Engineering and Materials Science Independent Study

Bone metastasis in breast cancer patients is a prominent problem, with 70% of metastatic breast cancer patients having bone metastasis.^[1] The resulting complications are painful and decrease patient survival rate.^[1,3] This study is based on the previous lab work of Ross et al., who found that bone metastatic breast cancer cells over-express the integrin αvβ3. Through a series of in vitro experiments, this study sought to investigate the degree to which the single lipid membrane αvβ3-targeted nanoparticles could function as a less toxic and more effective treatment to bone metastatic breast cancer.

Geometric Characterization Of Mouse Intestines Under Applied Loading, Sara-Marie Reed

Mechanical Engineering and Materials Science Independent Study

The purpose of this experiment was to apply bench-top imaging (optical coherence tomography or OCT) to intestinal and pelvic floor tissues from mice, focusing on the visualization of these anatomical structures and geometric characterization under applied loading. Quantifying such properties of the intestine will allow for further understanding of this tissue’s response to pressure and its mechanical properties. To supplement the images gathered from the OCT imaging (loaded and unloaded tissue samples), the histology was also examined to further understand the structure of these tissues.

Production Of Nbvzr Refractory Multi-Principal Element Alloy For Research Application, Mikayla Jenkins

Mechanical Engineering and Materials Science Independent Study

The objective of this study was to learn about high entropy alloys, multi-principal element alloys, and refractory alloys, as well as to produce a refractory multi-principal element alloy, NbVZr. This report focuses on the compositional error resulting from sample mass before and after an initial arc melting process. With an expected sample weight of 15.00 g per sample, material was initially measured within an average of 0.036% error. After this initial melting process, mass error increased by 0.030%, resulting in an average error of 0.1201%. This can be attributed to sample vaporization, oxidation, and displacement of small particles. For future …

Effects Of Artificial Light Spectra And Sucrose On The Leaf Pigments, Growth, And Rooting Of Blackberry (Rubus Fruticosus) Microshoots, Yaser Hassan Dewir, Ali Mohsen Al-Ali, Hail Z. Rihan, Thobayet Alshahrani, Mona S. Alwahibi, Khalid F. Almutairi, Yougasphree Naidoo, Michael P. Fuller

School of Biological and Marine Sciences

Light emitting diodes (LEDs) are potential light sources for in vitro plant cultures. Here, axillary blackberry shoots were grown in MS medium with indole-3-butyric acid (1 mg L−1), naphthalene acetic acid (0.5 mg L−1), and sucrose supplementation (0–60 g L−1) and the cultures were incubated under four light treatments: three LED light treatments (blue + red light (2:1 spectral ratio), blue + red light (1:2), and cool + warm white light (1:1)) and a standard florescent tube white spectrum treatment. Sucrose was indispensable for rooting of blackberry microshoots. Sucrose concentrations up to 45 g L−1 increased total root length and …

Credit Card With Dynamic Credit Rating Display, Manas Sharma

Defensive Publications Series

The present disclosure relates to a method, system and payment card for dynamically displaying credit rating. As such, credit related information and transaction information of a cardholder associated with a payment card is received from an issuer server. The credit related information and transaction information of the cardholder are used for predicting one or more behavioural parameters associated with the cardholder. Further, the one or more values are used for determining a credit rating of the cardholder. The credit rating of the cardholder may be displayed on the payment card or cardholder device or on any merchant device facilitating transaction …

Seamless Short Video Consumption Via A Web Browser Or Application, Kerstin Kuehne, Aditya Gupta, Alihan Livdumlu, Andrea Zilio, Anirban Mitra, Ankit Gupta, Danielle Marshak, Debosree Roy, Faizaan Marolia, Jamie Keene, Mary Koliadenko, Rohan Mathai, Shilpa Jindal, Yogesh Kadam, Rishi Vikram, Clay Minicus, Amay Champaneria, Hilary Hengesbach, Debra Kumar

Defensive Publications Series

The present disclosure describes computer-implemented systems and methods for assisting a user to navigate and consume videos hosted on third-party platforms. In response to a user query, a plurality of video results responsive to the user query are displayed and upon selection of one of the plurality of video results, a web browser retrieves and renders a webpage including the video from the respective video hosting platform. The system can playback the video and generate similar video results from a plurality of video hosting platforms pertaining to a given user query.

Liberalism And Humanism - The Arab Case, Ibrahem Badran

Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب

Liberalism as a school of thought focuses on individul freedom, the rule of law, constitutional government, economic freedom, tolerance of others in thought, apinion and belief, and denial of authoritative regimes. The practical interpretation of liberalism is institutional democracy, equal citizenship and freedom of ownership. Liberalism stems from the fact that individiaul freedom and right is the essence so no authority should not block such freedom. Because "Liberal Capitalism" is not an ideology, every society builds its economy and institutions according to what its experts, thinkers and environment dictate. Hence, countries differ totally in the details of its economic and …

Effect Of Freeze Thaw Cycles On Elbow Mobility In A Long Evans Rat, Sophia Miller

Mechanical Engineering and Materials Science Independent Study

Throughout the 2022 Fall semester I worked in Dr. Lake’s musculoskeletal soft tissue lab on the Post Traumatic Joint Contracture(PTJC) project. Previous work on this project used a rat model of the elbow to explore different factors affecting this disease and potential treatments. There are many different tests used to quantify the rats progress through this condition. One is range of motion testing. The typical procedure for this project is to sacrifice the animals and then freeze them before performing range of motion testing. This project tested the animals range of motion immediately after sacrifice and then again after the …

Multipolymer Microsphere Delivery Of Sars-Cov-2 Antigens, Farah Shahjin, Milankumar Patel, Jatin Machhi, Jacob D. Cohen, Mohammad Ullah Nayan, Pravin Yeapuri, Chen Zhang, Emiko Waight, Mahmudul Hasan, Mai Mohamed Abdelmoaty, Prasanta K. Dash, You Zhou, Irene Andreu, Howard E. Gendelman, Bhavesh D. Kevadiya

Nebraska Center for Biotechnology: Faculty and Staff Publications

Effective antigen delivery facilitates antiviral vaccine success defined by effective immune protective re- sponses against viral exposures. To improve severe acute respiratory syndrome coronavirus-2 (SARS-CoV- 2) antigen delivery, a controlled biodegradable, stable, biocompatible, and nontoxic polymeric micro- sphere system was developed for chemically inactivated viral proteins. SARS-CoV-2 proteins encapsulated in polymeric microspheres induced robust antiviral immunity. The viral antigen-loaded microsphere sys- tem can preclude the need for repeat administrations, highlighting its potential as an effective vaccine.

Testimonios Of Civic Pedagogy: Developing Critical Literacy Skills Using Civics And Holocaust Studies, Tameka Parenti

USF Tampa Graduate Theses and Dissertations

Civics using Holocaust Studies offer a variety of pedagogical advantages. Regardless of the topic, Holocaust events can be used to build critical analytical skills and cultivate essential literacy skills about the social world. Further, the Holocaust can be used to introduce and grapple with the complex/abstract ideas of the civics content. Given the relationship that social studies has to critical literacy development, civics used in conjunction with Holocaust resources present teacher(s) (educators) with the opportunity to explore (theoretical) concepts foregrounding manifold relationships making up the social world.

This research aimed to examine how secondary students connect to the social world …

Anti-Cancer Mechanisms Of Action Of Therapeutic Alternating Electric Fields (Tumor Treating Fields [Ttfields]), Shadi Shams, Chirag B Patel

Faculty, Staff and Student Publications

Despite improved survival outcomes across many cancer types, the prognosis remains grim for certain solid organ cancers including glioblastoma and pancreatic cancer. Invariably in these cancers, the control achieved by time-limited interventions such as traditional surgical resection, radiation therapy, and chemotherapy is short-lived. A new form of anti-cancer therapy called therapeutic alternating electric fields (AEFs) or tumor treating fields (TTFields) has been shown, either by itself or in combination with chemotherapy, to have anti-cancer effects that translate to improved survival outcomes in patients. Although the pre-clinical and clinical data are promising, the mechanisms of TTFields are not fully elucidated. Many …

Análisis De Referentes Metodológicos Para La Elaboración De Una Taxonomía De Animación Funcional, Raquel Ávila Muñoz, Jorge Clemente Mediavilla, María José Pérez-Luque

Artículos científicos

El uso de animaciones en el diseño de interfaces ha experimentado un incremento vertiginoso en los últimos años. La animación ha pasado de ser denostada por los expertos en usabilidad a ser un elemento fundamental a la hora de configurar el diseño visual de las aplicaciones para móviles. Baecker y Small desarrollan en 1990 la que está considerada como la primera taxonomía general de la animación en la interfaz, recogiendo los usos presentes en las primeras interfaces gráficas de usuario. En este artículo revisamos la metodología seguida por los pioneros y analizamos la perspectiva adoptada por otros autores que elaboran …

Promoting Rigor And Sustainment In Implementation Science Capacity Building Programs: A Multi-Method Study., Amy G Huebschmann, Shelly Johnston, Rachel Davis, Bethany M Kwan, Elvin Geng, Debra Haire-Joshu, Brittney Sandler, Demetria M Mcneal, Ross C Brownson, Borsika A Rabin

2020-Current year OA Pubs

BACKGROUND: The field of Implementation science (IS) continues to evolve, and the number and type of IS capacity building Programs (ISCBPs) are in flux. These changes push the field to revisit the accepted IS competencies and to guide sustainment of ISCBPs. Our objectives were: (1) compare characteristics of current ISCBPs; (2) identify recommendations to support ISCBP sustainment; (3) measure how often ISCBPs address IS competencies; (4) identify novel and important IS competencies for the field.

METHOD: This multi-method study included ISCBPs delivering structured, longitudinal IS training, excluding single courses and brief workshops. We used three complementary methods to meet our …

Mechanical And Thermal Load Effect On Piston Crown Of A Biogas Engine: A Simulation Approach, Truc Nguyen The, Anh Duc Tran, Cam Van Nguyen, Khac Tung Nguyen, Dinh Long Hoang, Xuan Phong Trinh, Nguyen Duc Khanh

ASEAN Journal on Science and Technology for Development

This paper presents the study results on stress and deformation of the piston crown of a biogas engine converted from a conventional diesel engine using dedicated software. The original diesel engine was modified to reduce the compression ratio to suit biogas fuel. The original engine's combustion chamber and compression ratio were changed by modifying the piston crown to a heron type. The parameters of in-cylinder pressure and temperature were determined by the thermodynamic simulation software AVL Boost. Research results show that the in-cylinder pressure decreased compared to diesel when using biogas fuel, but the temperature increased. The infinite element method-based …

Temporal Changes In Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling After Acute Myocardial Infarction, Xiong Chang Lim, Chenyuan Huang, Siti Maryam J.M. Yatim, Suet Yen Chong, Sock Hwee Tan, Xiaoxun Yang, Caryn L. Heidt, Jodi Pedersen, Michael Talanker, Harshvardhan Modh, Matthias G. Wacker, Giorgia Pastorin, Siew Pang Chan, A. Mark Richards, Chris J. Charles, Mark Y. Chan, Jiong Wei Wang

Michigan Tech Publications, Part 1

The subset of plasma extracellular vesicles (EVs) that coprecipitate with low-density lipoprotein (LDL-EVs) carry coagulation and fibrinolysis pathway proteins as cargo. We investigated the association between LDL-EV hemostatic/fibrinolysis protein ratios and post-acute myocardial infarction (post-AMI) left ventricular (LV) remodeling which precedes heart failure. Protein concentrations of von Willebrand factor (VWF), SerpinC1 and plasminogen were determined in LDL-EVs extracted from plasma samples obtained at baseline (within 72 h post-AMI), 1 month and 6 months post-AMI from 198 patients. Patients were categorized as exhibiting adverse (n = 98) or reverse (n = 100) LV remodeling based on changes in LV end-systolic volume …

Suitability Of Current Single-Cylinder Diesel Engines Available In Indonesia With New Indonesian National Standard (Sni 119:2020), Sukra Kurnia Fajar Adhi, Setiapraja Hari, Soewono Respatya Teguh, Sumartono Hari

ASEAN Journal on Science and Technology for Development

Diesel engines have been utilized for various purposes in Indonesia. Diesel engine manufacturers have developed designs and competed with each other to win the market in Indonesia. Nationally and internationally recognized standards are required to ensure the quality of products for Indonesia and the international market. The Indonesian National Standard (SNI) 119 is one of the recognized standards for single-cylinder diesel engine in Indonesia. Compared with the previous SNI 0119:2012, SNI 119:2020 has revised the limits of some parameters. This study evaluated the passing data of SNI test results from 2015 to 2020 and then analyzed the distribution of engines …

Analysis Of Surface Water Availability To Meet Agricultural Water Demands In Kediri Regency, Indonesia, Sekaranom Andung Bayu, Purnama I.G. Setyawan, Cahyadi Ahmad, Andika Neil, Febriarta Erik, Nurjani Emilya, Firmansyah Anugrah Jorgi, Maghfiroh, Larasati Chafda, Septyo Novanna Dwi

ASEAN Journal on Science and Technology for Development

This study aims to analyze the potential of surface water to meet agricultural water needs in Kediri Regency, Indonesia. Data from government agencies (i.e., Indonesian Bureau of Meteorology, Climatology, and Geophysics and Kediri Agriculture Office) and fieldwork were analyzed to achieve the research objectives. The data obtained consisted of rainfall, temperature, infiltration capacity, soil texture, root depth, and agricultural land area. The potential of surface water resources was calculated by using the Thornthwaite–Mather water balance method. The water balance results were compared with agricultural water demands, which were calculated on the basis of the area of agricultural land and type …

Determining Kinetic Parameters Of Cellulose And Lignin Pyrolysis By Gaussian Process Regression (Gpr) Method, Pichayaporn Viriya-Amornkij, Kazunori Kuwana

Progress in Scale Modeling, an International Journal

The ignition and flame-spread processes in the forest and urban fires involve the pyrolysis reactions of biomass materials. One of the most common methods for estimating the fire performance of a material is the evaluation of kinetic parameters, i.e., activation energy (𝐸), pre-exponential factor (𝐴), and reaction model (𝑓(𝛼)), from thermogravimetric analysis (TG) data. Typically, 𝐸 is estimated based on an Arrhenius-type equation such as Kissinger, Kissinger-Akahira-Sunose (KAS), and Friedman equations. Then, its value is adjusted along with other parameters by assuming a reaction model, e.g., the 𝑛-order model. This study proposes a Gaussian process regression (GPR) method to determine …

Influence Of Wire Arc Additive Manufacturing Beads’ Geometry And Building Strategy: Mechanical And Structural Behavior Of Er70s-6 Prismatic Blocks, Ahmed Elsokaty, Omar Oraby, Sameha Sadek, Hanadi G. Salem

Faculty Journal Articles

No abstract provided.

Fire-Resistance Testing Procedures For Construction Elements—A Review, Shashikant Chaturvedi, Ajitanshu Vedrtnam, Maged A. Youssef, Martin T. Palou, Gonzalo Barluenga, Kishor Kalauni

Civil and Environmental Engineering Publications

Fire accidents are a significant risk to human life and civil infrastructure. As a countermeasure, the regulatory bodies of different countries have established standards for evaluating the performance of construction elements during fire exposure. ISO 834 is the globally accepted fire-resistance testing standard. Other standards include ASTM E119, BS 476, IS 3809, JIS A 1304, AS 1503, EN 1363, and GB/T 9978, which are utilized by the US, Britain, India, Japan, Australia, Europe, and China, respectively. This article presents a summary and comparison of the fire-resistance testing standards. In reality, standard tests for isolated structural members may not efficiently portray …

New Semi-Dwarfing Alleles With Increased Coleoptile Length By Gene Editing Of Gibberellin 3-Oxidase 1 Using Crispr-Cas9 In Barley (Hordeum Vulgare L.), Jingye Cheng, Camilla Hill, Yong Han, Tianhua He, Xingguo Ye, Sergey Shabala, Ganggang Guo, Meixue Zhou, Ke Wang, Chengdao Li

Grain and Other Field Crops Research Articles

The green revolution was based on genetic modification of the gibberellin (GA) hormone system with “dwarfing” gene mutations that reduces GA signals, conferring shorter stature, thus enabling plant adaptation to modern farming conditions. Strong GA-related mutants with shorter stature often have reduced coleoptile length, discounting yield gain due to their unsatisfactory seedling emergence under drought conditions. Here we present gibberellin (GA) 3-oxidase1 (GA3ox1) as an alternative semi-dwarfing gene in barley that combines an optimal reduction in plant height without restricting coleoptile and seedling growth. Using large-scale field trials with an extensive collection of barley accessions, we showed that a natural …

Rolling Up Single Layer Polymer, Xiaoyuan Huang

Mechanical Engineering and Materials Science Independent Study

This report introduces two way of rolling up materials and conclude a reasonable two ways to roll up a single layer of polymer. Four experiment procedures are described, and three of them were finished during the Fall 2022 semester.

Safety Related Hvac Systems In Pwr Nuclear Power Plants, Florie Markwell

Mechanical Engineering and Materials Science Independent Study

This paper is for the completion of MEMS 500 - Independent Study at Washington University in St. Louis. The materials and coursework are based off MEMS 5420 HVAC Analysis and Design I. This course covered readings and problems from chapters 1-8 of Heating, Ventilating, and Air-Conditioning Design and Analysis - sixth edition by McQuiston, Parker, and Spitler. Topics included moist air prop- erties, indoor environmental quality (comfort and health), heat transmission in building structures, space heating loads, and cooling loads. This paper focuses on a few of the safety related HVAC systems found in PWR or pressurized water reactor type …

Global South Research Collaboration: A Comparative Perspective, Abdoulaye Gueye, Edward Choi, Carolina Guzmán-Valenzuela, Gustavo Gregorutti

Faculty Publications

Research collaboration has become a major research topic in the social sciences. While this literature has mainly focused on collaborative dynamics in the Global North, more recent studies have examined these dynamics within the Global South. This article expands the scope of analysis by comparing the level of co-publications by Global South-based scholars with Global South-based colleagues and that between academics at Global South institutions and researchers in Global North universities. It shows that academic partnerships within the Global South are less common than instances of collaboration between the Global South and Global North. The relatively weak Global South collaborative …

Exploring The Training And Practice Experiences Of Male School Counselors, Eric S. Davis, Michele Pinellas, Sarah Putnam, Rosemarie Beahm

Journal of Counselor Preparation and Supervision

Males are underrepresented as school counselors and may experience stigma associated with being viewed as less masculine, sexual deviants, or unqualified. Despite these aspects, research has shown benefits for school stakeholders based in the diverse perspectives male school counselors can provide. The purpose of this phenomenological qualitative research study was to understand the lived experiences of 25 male school counselors from across the United States. Based on the thematic analysis findings, we will discuss specific implications and recommendations for male school counselor training, supervision, and practice.

30 Años De Transformación Regional. Soacha, Jesús Enrique Pabón Quintero, Claudia Sofía González Sánchez, Catalina Ramírez Machado, Edwar Javier Prieto Suárez, Eduar Alonso Ceballos Bernal, Yury Julieth Garzón Rodríguez, Diana Karina López Carreño, Micher Alexander González Monroy, Yudy Amparo Narváez Vallejo, Dilia Inés Molina Cubillos, Rubén Dario Rodríguez Useche

Institucional

El presente libro contiene simplificadamente, la reseña histórica de la Universidad de Cundinamarca, Extensión Soacha, la cual hace referencia desde su nacimiento hasta los avances, transformaciones e impactos que ha generado no solo en el municipio de Soacha, sino municipios como Sibaté, Funza, Mosquera y la misma capital del País, Bogotá. Incluye además la oferta académica y la contribución e implementación del Modelo Educativo Digital Transmoderno - MEDIT en la Extensión. De igual manera cuenta con los capítulos relacionados con la Ciencia, Tecnología e Innovación del programa de Ciencias del Deporte y la Educación Física desde el MEDIT; el cual …

30 Años De Transformación Regional. Chía Y Zipaquirá, José Zacarías Mayorga Sánchez, Luz Deicy Flórez Espinal, Viviana Andrea Caballero Moreno, Luz Mireya Rincón Mora, John Jairo Zambrano Rocha, Eduard Neftali Gutiérrez, Carlos Augusto Trujillo Padilla, Carlos Germán González Pedraza, Juan Manuel Urrego Laurin, León Fabio Salcedo Ortiz, Ana Betina Morgante Combariza, Eduardo Ernesto Castro Neira

Institucional

En el trigésimo aniversario de vida universitaria de nuestro claustro académico, la Extensión Chía, recordamos con agrado el proceso desarrollado en esta corta pero muy exitosa actividad universitaria. Conocida como la ciudad de La Luna, el municipio de Chía es un importante centro empresarial e industrial del departamento de Cundinamarca, sede de varias instituciones de educación superior. Hoy es un referente de primer orden el proceso de desarrollo económico y social que ha atravesado la provincia Sabana Centro, en especial, debido a la cercanía a la capital del país. Es un centro cultural y turístico por excelencia con una rica …

Two Sides To Every Psyche: Implications Of Positive Psychology For "Mental Health" Research In Engineering Education, Muhammad Asghar, Angela Minichiello

Engineering Education Student Research

“Mental Health.” Throughout the 20th century, these familiar words have been quietly commandeered by a physiological model of health (Greenspoon & Saklofske, 2001). Unknowingly, society conspired to use these words—colloquially, academically, and scientifically—for the sole purpose of depicting (or implying) negative states of the human mind. Since the origins of psychological research over 100 years ago, our understanding of what mental health is has been conflated with notions of mental illness. Resultantly, we have tacitly agreed that the presence or absence of suffering is the sole implication of our mental health (Horwitz & Scheid, 1999).

Retrospective-My First Five Years As President, December 23, 2022, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

Collaborative Interprofessional Health Science Student Led Realistic Mass Casualty Incident Simulation, Deborah L Mccrea, Robert C Coghlan, Tiffany Champagne-Langabeer, Stanley Cron

Faculty, Staff and Student Publications

In collaboration, a health science university and a fire department offered a mass casualty incident (MCI) simulation. The purpose of this study was to evaluate a cross-section of student health care providers to determine their working knowledge of an MCI. Students were given a pretest using the Emergency Preparedness Information Questionnaire (EPIQ) and the Simple Triage and Rapid Transport (START) Quiz. The EPIQ instrument related to knowledge of triage, first aid, bio-agent detection, critical reporting, incident command, isolation/quarantine/decontamination, psychological issues, epidemiology, and communications. The START Quiz gave 10 scenarios. Didactic online content was given followed by the simulation a few …