Digital Commons Network^™

International Consensus Conference Recommendations On Ultrasound Education For Undergraduate Medical Students, Richard A Hoppmann, Jeanette Mladenovic, Lawrence Melniker, Radu Badea, Michael Blaivas, Miguel Montorfano, Alfred Abuhamad, Vicki Noble, Arif Hussain, Gregor Prosen, Tomás Villen, Gabriele Via, Ramon Nogue, Craig Goodmurphy, Marcus Bastos, G Stephen Nace, Giovanni Volpicelli, Richard J Wakefield, Steve Wilson, Anjali Bhagra, Jongyeol Kim, David Bahner, Chris Fox, Ruth Riley, Peter Steinmetz, Bret P Nelson, John Pellerito, Levon N Nazarian, L Britt Wilson, Irene W Y Ma, David Amponsah, Keith R Barron, Renee K Dversdal, Mike Wagner, Anthony J Dean, David Tierney, James W Tsung, Paula Nocera, José Pazeli, Rachel Liu, Susanna Price, Luca Neri, Barbara Piccirillo, Adi Osman, Vaughan Lee, Nitha Naqvi, Tomislav Petrovic, Paul Bornemann, Maxime Valois, Jean-Francoise Lanctot, Robert Haddad, Deepak Govil, Laura A Hurtado, Vi Am Dinh, Robert M Dephilip, Beatrice Hoffmann, Resa E Lewiss, Nayana A Parange, Akira Nishisaki, Stephanie J Doniger, Paul Dallas, Kevin Bergman, J Oscar Barahona, Ximena Wortsman, R Stephen Smith, Craig A Sisson, James Palma, Mike Mallin, Liju Ahmed, Hassan Mustafa

Department of Radiology Faculty Papers

OBJECTIVES: The purpose of this study is to provide expert consensus recommendations to establish a global ultrasound curriculum for undergraduate medical students.

METHODS: 64 multi-disciplinary ultrasound experts from 16 countries, 50 multi-disciplinary ultrasound consultants, and 21 medical students and residents contributed to these recommendations. A modified Delphi consensus method was used that included a systematic literature search, evaluation of the quality of literature by the GRADE system, and the RAND appropriateness method for panel judgment and consensus decisions. The process included four in-person international discussion sessions and two rounds of online voting.

RESULTS: A total of 332 consensus conference statements …

Artificial Light At Night Reverses Monthly Foraging Pattern Under Simulated Moonlight, Svenja Tidau, Jack Whittle, Stuart R. Jenkins, Thomas W. Davies

School of Biological and Marine Sciences

Mounting evidence shows that artificial light at night (ALAN) alters biological processes across levels of organization, from cells to communities. Yet, the combined impacts of ALAN and natural sources of night-time illumination remain little explored. This is in part due the lack of accurate simulations of the complex changes moonlight intensity, timing and spectra throughout a single night and lunar cycles in laboratory experiments. We custom-built a novel system to simulate natural patterns of moonlight to test how different ALAN intensities affect predator–prey relationships over the full lunar cycle. Exposure to high intensity ALAN (10 and 50 lx) reversed the …

Office Of Research, Economic Engagement And Outreach Update, July 27, 2022, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Predictors Of Post-Stroke Depression: A Retrospective Cohort Study, Durgesh Chaudhary, Isabel Friedenberg, Vishakha Sharma, Pragyan Sharma, Vida Abedi, Ramin Zand, Jiang Li

Student Publications

Despite reports of a high incidence and various predictors of post-stroke depression (PSD), the underdiagnosis and undertreatment rates of PSD are still high. This study aimed to examine the incidence of depression in stroke patients and identify factors associated with PSD. This was a retrospective cohort study on ischemic stroke patients from the Geisinger Neuroscience Ischemic Stroke (GNSIS) registry. The following statistical analyses were performed to predict PSD in the studied population: a Kaplan-Meier estimator and a Cox proportional hazards model. A total of 5882 patients were included in the study. The median age at the time of an ischemic …

A Sampling, Exposure And Receptor Framework For Identifying Factors That Modulate Behavioural Responses To Disturbance In Cetaceans, Cormac G. Booth, Naomi Brannan, Rebecca Dunlop, Ari Friedlander, Saana Isojunno, Patrick Miller, Nicola Quick, Brandon Southall, Enrico Pirotta

School of Biological and Marine Sciences

No abstract provided.

Masturbatory Behaviors Among Older Adult Populations: A Literature Review, Brandon Tischer

Journal of Undergraduate Research at Minnesota State University, Mankato

Sexual behaviors, such as masturbation, extend into older adulthood (50+ years in chronological age) and are present at all stages of the aging process. Different living situations and circumstances for older adults can affect masturbatory behavior, such as death of spouse, living in long-term care facilities, and cognitive decline. This literature review evaluates extant research on older adult masturbation, comprising 29 articles included in the final review, all published between 1991 and 2021. They consist of literature reviews, meta-studies, cross-sectional studies, semi-structured interviews, systematic reviews, and case studies. Current evidence suggests that masturbatory behaviors are an important part of older …

Designing Harvesting And Hauling Cost Models For Energy Cane Production For Biorefineries, Prabodh Illukpitiya, Firuz Yuldashev, Kabirat Nasiru

Agricultural and Environmental Sciences Faculty Research

The harvesting and hauling operations of bioenergy feedstock is an important area in biofuel production. Production costs can be minimized by maintaining optimal machinery units for these operations. The objective of this study is to design an optimal harvesting unit for bioenergy refinery and estimate harvesting and hauling costs of energy cane. A biorefinery with the annual capacity of processing twenty-five million imp. gallons of ethanol were considered. Given the efficiency of harvesting, a two-row soldier system was considered. Considering the year-round supply of energy cane to the refinery, the optimal machinery unit was designed, and the combined operation costs …

Missouri Alot - Dc Experience, Amy Bax

Title III Professional Development Reports

I want to thank Lincoln University for sponsoring this trip. I had access to many high-level people in DC that wanted to hear my story of agriculture. These are people that have the power to create legislative practices and policies that are favorable to the agricultural industry. I had the opportunity to advocate for Lincoln and Lincoln University students.

Biology Graduate Seeks Personal Approach To Healthcare, Taylor University

2022 Website News Stories

No abstract provided.

Covid-19 Newsletter (Vol. 129), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

International Law As A Vehicle For Peace: Feminist Engagements., Hilary Charlesworth, Christine M. Chinkin, Shelley Wright

Book Chapters

This is an edited transcript of three conversations on Zoom which took place on 3 February, 24 March and 23 April 2021. Hilary spoke from Melbourne and the NSW South Coast in Australia, Christine was based in Southampton in the UK and Shelley was in Lund, British Columbia in Canada – all of us in various phases of COVID lockdown.

The first conversation focused on how our journey started, including the ‘Feminist approaches’ article and the impact it had, or has not had, on international law. The second conversation focused more on our subsequent work, and the different approaches we …

Hair Zidovudine Concentrations Predict Virologic Outcomes Among People Living With Hiv/Aids In China, Yan Wu, Shuaifeng Liu, Liuxi Chu, Quan Zhang, Jin Yang, Shan Qiao, Xiaoming Li Ph.D., Yuejiao Zhou, Huihua Deng, Zhiyong Shen

Faculty Publications

Background: Hair antiretroviral concentrations are an objective and non-invasive measure of adherence to long-term antiretroviral therapy (ART) and can further predict virologic outcomes among people living with HIV/AIDS (PLWH). Zidovudine, one of the mainstream antiretrovirals in China, has been verified to have high reliability in adherence assessment, especially for its hair concentrations. However, data are limited in its predicting virologic outcomes. Therefore, this study aimed to characterize whether hair zidovudine concentrations can predict virologic suppression among Chinese PLWH compared with hair lamivudine concentrations and two self-reported measures, the overall frequency of adherence behaviors and percentage adherence. Methods: This cross-sectional study …

Method To Reduce Microbial Bloom In Poultry Hatchery, Ross Wolfenden, Jacob David Lum, Billy M. Hargis, Lisa R. Bielke, Lucas Graham

Patents Granted

Spore forming bacteria and Lactic Acid Bacteria for application in poultry hatcher cabinets to alter the bacterial bloom towards a more beneficial microbiota, positively affecting performance parameters such as mortality, body weight gain and feed conversion ratio throughout production.

Two Courts, Two Conclusions: Abortion Law In India, Gauri Pillai

Popular Media

On 15 July 2022, the Delhi High Court, in Ms X v The Principal Secretary of Health and Family Welfare Department Government of NCT of Delhi (‘Ms X’), denied an unmarried woman permission to terminate her unwanted pregnancy at 23 weeks under Section 3 of the Medical Termination of Pregnancy Act, 1971. A week later, through an ad-interim order, the Supreme Court allowed the woman’s appeal against the Delhi High Court’s order, permitting termination as long as a Medical Board confirms that abortion is medically safe for the pregnant woman. In this post, I discuss both these orders, which differ …

Sweet Taste Signaling: The Core Pathways And Regulatory Mechanisms, Sunil Kumar Sukumaran, Salin Raj Palayyan

Department of Nutrition and Health Sciences: Faculty Publications

Sweet taste, a proxy for sugar-derived calories, is an important driver of food intake, and animals have evolved robust molecular and cellular machinery for sweet taste signaling. The overconsumption of sugar-derived calories is a major driver of obesity and other metabolic diseases. A fine-grained appreciation of the dynamic regulation of sweet taste signaling mechanisms will be required for designing novel noncaloric sweeteners with better hedonic and metabolic profiles and improved consumer acceptance. Sweet taste receptor cells express at least two signaling pathways, one mediated by a heterodimeric G-protein coupled receptor encoded by taste 1 receptor members 2 and 3 (TAS1R2 …

Thioester Synthesis By A Designed Nickel Enzyme Models Prebiotic Energy Conversion, A. C. Manesis, A. Yerbulekova, Jason M. Shearer, H. S. Shafaat

Chemistry Faculty Research

The formation of carbon-carbon bonds from prebiotic precursors such as carbon dioxide represents the foundation of all primordial life processes. In extant organisms, this reaction is carried out by the carbon monoxide dehydrogenase (CODH)/acetyl coenzyme A synthase (ACS) enzyme, which performs the cornerstone reaction in the ancient Wood-Ljungdahl metabolic pathway to synthesize the key biological metabolite, acetylCoA. Despite its significance, a fundamental understanding of this transformation is lacking, hampering efforts to harness analogous chemistry. To address these knowledge gaps, we have designed an artificial metalloenzyme within the azurin protein scaffold as a structural, functional, and mechanistic model of ACS. We …

Targeting De Novo Lipogenesis And The Lands Cycle Induces Ferroptosis In Kras-Mutant Lung Cancer, Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I Wistuba, John D Minna, Jeffrey G Mcdonald, Pier Paolo Scaglioni

Faculty, Staff and Student Publications

Mutant KRAS (KM), the most common oncogene in lung cancer (LC), regulates fatty acid (FA) metabolism. However, the role of FA in LC tumorigenesis is still not sufficiently characterized. Here, we show that KMLC has a specific lipid profile, with high triacylglycerides and phosphatidylcholines (PC). We demonstrate that FASN, the rate-limiting enzyme in FA synthesis, while being dispensable in EGFR-mutant or wild-type KRAS LC, is required for the viability of KMLC cells. Integrating lipidomic, transcriptomic and functional analyses, we demonstrate that FASN provides saturated and monounsaturated FA to the Lands cycle, the process remodeling oxidized phospholipids, such as PC. Accordingly, …

Hematopoietic-Mesenchymal Signals Regulate The Properties Of Mesenchymal Stem Cells, Sanshiro Kanazawa, Hiroyuki Okada, Dan Riu, Yo Mabuchi, Chihiro Akazawa, Junichi Iwata, Kazuto Hoshi, Atsuhiko Hikita

Faculty, Staff and Student Publications

It is well known that the properties of hematopoietic stem/progenitor cells (HSCs), such as their self-renewal ability and multipotency, are maintained through interactions with mesenchymal stem/stromal cells (MSCs). MSCs are rare cells that are present in the bone marrow and are useful for clinical applications due to their functional ability. To obtain the necessary number of cells, MSCs must be cultured to expand, but this causes a remarkable decrease in stem cell properties, such as multipotency and proliferation ability. In this study, we show that the c-Mpl signal, which is related to the maintenance of hematopoietic stem cells, has an …

Fluid-Structure Interaction With Kelvin-Voigt Damping And Quantized State Integration Methods, Rasika Lasantha Mahawattege

Electronic Theses and Dissertations Archive

The class of fluid-structure interaction models in the physical dimension d = 2,3 has been the object of intense mathematical studies in the past several years. In the case of static interface, justified to be appropriate for small, rapid oscillations of the structure, the typical configuration considers a structure – modeled by a d-dimensional wave-type equation –surrounded by a fluid –modeled by the d-dimensional dynamic Stokes equation involving pressure. Coupling takes place at the common interface of the two media where the individual equations evolve and is given by differential operators. Thus, the overall system provides a physical illustration of …

Effect Of High- Vs Low-Dose Tranexamic Acid Infusion On Need For Red Blood Cell Transfusion And Adverse Events In Patients Undergoing Cardiac Surgery: The Optimal Randomized Clinical Trial, Jia Shi, Chenghui Zhou, Wei Pan, Hansong Sun, Sheng Liu, Wei Feng, Weijian Wang, Zhaoyun Cheng, Yang Wang, Zhe Zheng, Optimal Study Group

Faculty, Staff and Students Publications

IMPORTANCE: Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid provides better blood-sparing effect than a low dose without increasing the risk of thrombotic complications or seizures in cardiac surgery.

OBJECTIVE: To compare the efficacy and adverse events of high-dose vs low-dose tranexamic acid in patients undergoing cardiac surgery with cardiopulmonary bypass.

DESIGN, SETTING, AND PARTICIPANTS: Multicenter, double-blind, randomized clinical trial among adult patients undergoing cardiac surgery with cardiopulmonary bypass. The study enrolled 3079 patients at 4 hospitals in China from December 26, 2018, to …

Development Of Soil Microbial Community Structure In Created And Natural Wetlands, Wendy A. Owens

Theses

Wetlands are ecologically and economically important, providing ecosystem services such as biogeochemical cycling, carbon sequestration, flood mitigation, and wildlife habitat. Many of these services are the result of the unique microbial communities found in wetlands. Degradation and destruction of wetlands, from direct human development or indirect stressors caused by climate change, pollution, or invasive species, disrupts community structure and provision of services. Although restoration has been adopted as a mechanism to counteract net loss of function, the success rate in achieving functional equivalence with natural wetlands is low. To improve wetland conservation and outcomes for wetland creation, a better understanding …

Qualifying Factors That Predict Weight Loss Success Within Diet Interventions, Jordan Losavio

LSU Master's Theses

Evidence-based diet strategies lead to weight loss for some, while for others, the same diet approach could result in trivial weight loss or even in weight gain. This prompts the underlying research question: what factors predict that a given diet strategy will be efficacious for some, but not for others? This research was a secondary analysis of clinical weight loss studies to determine which factors influence an individual’s weight loss success for three diet intervention strategies: low-carbohydrate, low-fat, and low-calorie. A combination of physiological, psychological, behavioral, and dietary factors was evaluated for each diet study. Multiple linear regression and logistic …

Real-World Use Of Tisagenlecleucel In Infant Acute Lymphoblastic Leukemia., Amy Moskop, Lauren Pommert, Christina Baggott, Snehit Prabhu, Holly L. Pacenta, Christine L. Phillips, Jenna Rossoff, Heather E. Stefanski, Julie-An Talano, Steve P. Margossian, Michael R. Verneris, Douglas Myers, Nicole A. Karras, Patrick A. Brown, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Rachel Wilcox, Cara A. Rabik, Vanessa A. Fabrizio, Vasant Chinnabhandar, A Yasemin Goksenin, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Erin M. Guest, Erin H. Breese, Liora M. Schultz

Manuscripts, Articles, Book Chapters and Other Papers

Infants with B-cell acute lymphoblastic leukemia (B-ALL) have poor outcomes because of chemotherapy resistance leading to high relapse rates. Tisagenlecleucel, a CD19-directed chimeric antigen receptor T-cell (CART) therapy, is US Food and Drug Administration approved for relapsed or refractory B-ALL in patients ≤25 years; however, the safety and efficacy of this therapy in young patients is largely unknown because children(n = 14). Sixty-four percent of patients (n = 9) achieved minimal residual disease-negative remission after CART and 50% of patients remain in remission at last follow-up. All patients with high disease burden at time of CART infusion (>M1 marrow) …

Heart Failure In General And Cardiac Transplant Patients With Covid-19, Munish Sharma, Gowthami Sai Kogilathota Jagirdhar, Kalpalatha K Guntupalli, Rahul Kashyap, Salim Surani

Faculty, Staff and Students Publications

Coronavirus disease 2019 (COVID-19) is primarily an infection of the respiratory tract, but it can have multisystem manifestations. Cardiac complications of COVID-19 can range from acute myocardial injury, cardiac arrhythmias, or heart failure, amongst others. Heart failure (HF) in COVID-19 can be a de novo process or due to worsening of pre-existing cardiovascular ailment. HF in a patient with COVID-19 not only poses challenges in clinical presentation and management of COVID-19 but also affect prognosis of the patient. This article aims to succinctly revisit the implications of this pandemic regarding pre-existing HF or new-onset HF based on prevailing data. It …

Persistent Ethnicity-Associated Disparity In Anti-Tumor Effectiveness Of Immune Checkpoint Inhibitors Despite Equal Access, Marcus A Florez, Jan O Kemnade, Nan Chen, Wendy Du, Anita L Sabichi, Daniel Y Wang, Quillan Huang, Courtney N Miller-Chism, Aparna Jotwani, Albert C Chen, David Hernandez, Vlad C Sandulache

Faculty, Staff and Students Publications

We reviewed response to immune checkpoint inhibitors (ICI) of 207 patients with diagnoses of lung or head and neck cancer treated with chemotherapy/ICI combination therapy and ICI monotherapy between 2015 and 2020 at one of three clinical pavilions associated with the Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine. Two of these pavilions (Harris Health System and the Michael E. DeBakey Veterans Affairs Medical Center) serve large minority populations and provide equal access to care regardless of means. 174 patients had a diagnosis of lung cancer (non-small cell or small cell) and 33 had a diagnosis of …

An Integrated Proteomic And Glycoproteomic Investigation Reveals Alterations In The N-Glycoproteomic Network Induced By 2-Deoxy-D-Glucose In Colorectal Cancer Cells, Cheng Ma, Hong-Yuan Tsai, Qi Zhang, Lakmini Senavirathna, Lian Li, Lih-Shen Chin, Ru Chen, Sheng Pan

Faculty, Staff and Students Publications

As a well-known glycolysis inhibitor for anticancer treatment, 2-Deoxy-D-glucose (2DG) inhibits the growth and survival of cancer cells by interfering with the ATP produced by the metabolism of D-glucose. In addition, 2DG inhibits protein glycosylation in vivo by competing with D-mannose, leading to endoplasmic reticulum (ER) stress and unfolded protein responses in cancer cells. However, the molecular details underlying the impact of 2DG on protein glycosylation remain largely elusive. With an integrated approach to glycoproteomics and proteomics, we characterized the 2DG-induced alterations in N-glycosylation, as well as the cascading impacts on the whole proteome using the HT29 colorectal cancer …

Cryo-Em Structures Of Alphavirus Conformational Intermediates In Low Ph-Triggered Prefusion States, Chun-Liang Chen, Thomas Klose, Chengqun Sun, Arthur S Kim, Geeta Buda, Michael G Rossmann, Michael S Diamond, William B Klimstra, Richard J Kuhn

2020-Current year OA Pubs

Alphaviruses can cause severe human arthritis and encephalitis. During virus infection, structural changes of viral glycoproteins in the acidified endosome trigger virus-host membrane fusion for delivery of the capsid core and RNA genome into the cytosol to initiate virus translation and replication. However, mechanisms by which E1 and E2 glycoproteins rearrange in this process remain unknown. Here, we investigate prefusion cryoelectron microscopy (cryo-EM) structures of eastern equine encephalitis virus (EEEV) under acidic conditions. With models fitted into the low-pH cryo-EM maps, we suggest that E2 dissociates from E1, accompanied by a rotation (∼60°) of the E2-B domain (E2-B) to expose …

Efficient Genome Editing Achieved Via Plug-And-Play Adenovirus Piggyback Transport Of Cas9/Grna Complex On Viral Capsid Surface, Zhi Hong Lu, Jie Li, Igor P Dmitriev, Elena A Kashentseva, David T Curiel

2020-Current year OA Pubs

The capacity to efficiently deliver the gene-editing enzyme complex to target cells is favored over other forms of gene delivery as it offers one-time hit-and-run gene editing, thus improving precision and safety and reducing potential immunogenicity against edited cells in clinical applications. Here we performed a proof-of-mechanism study and demonstrated that a simian adenoviral vector for DNA delivery can be repurposed as a robust intracellular delivery platform for a functional Cas9/guide RNA (gRNA) complex to recipient cells. In this system, the clinically relevant adenovirus was genetically engineered with a plug-and-display technology based on SpyTag003/SpyCatcher003 coupling chemistry. Under physiological conditions, an …

Imperialist Barriers: Indian Women’S Contributions To The British Suffrage Movement, Alexandra Viencek

Voces Novae

No abstract provided.

Laudanum And Lavender: Patent Medicines Prescribed To 19th Century American Women, Nat Pendergraft

Voces Novae

No abstract provided.