Digital Commons Network^™

Alterations In Executive Functioning Following Moderate Prenatal Alcohol Exposure: New Translational Insights, Sarah L. Olguin

Biomedical Sciences ETDs

While the lifelong difficulties that result from alcohol exposure in utero are well documented, Fetal Alcohol Spectrum Disorders (FASD) remain the most common neurodevelopmental syndrome. FASD patients struggle with executive control including attention, cognitive control, reward learning, and impulsivity. These self-regulation problems contribute to increased rates of school expulsion, incarceration, and substance use disorders. However, it is still unclear how prenatal alcohol exposure (PAE) affects executive control processes that lead to inappropriate behavior later in life. Here we examined the effect of PAE on 4 aspects of executive functioning paired with intervention or with translatable EEG-like recording, 1) control over …

The Impact Of The Covid-19 Pandemic And The Digital Divide On Public Education In New Mexico, Robert Christner

Teacher Education, Educational Leadership & Policy ETDs

The digital divide and digital equity have long been a concern for educators, and public schools. In 2020 when the COVID-19 global pandemic swept across the country, public schools closed for in person classes and moved to a new paradigm of online only classes, issues of digital equity and the digital divide became a critical focus for families and young learners seeking to continue their academic progress. New Mexico with its low population density, rural nature and lack of infrastructure was particularly vulnerable to issues of digital equity when public schools moved to online only classes. This study investigates the …

Maladaptive Positive Feedback Production Of Chrebpβ Underlies Glucotoxic Β-Cell Failure, Liora S Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A Stanley, Dirk Homann, Andrew F Stewart, James C Lo, Mark A Herman, Adolfo Garcia-Ocaña, Donald K Scott

Faculty, Staff and Students Publications

Preservation and expansion of β-cell mass is a therapeutic goal for diabetes. Here we show that the hyperactive isoform of carbohydrate response-element binding protein (ChREBPβ) is a nuclear effector of hyperglycemic stress occurring in β-cells in response to prolonged glucose exposure, high-fat diet, and diabetes. We show that transient positive feedback induction of ChREBPβ is necessary for adaptive β-cell expansion in response to metabolic challenges. Conversely, chronic excessive β-cell-specific overexpression of ChREBPβ results in loss of β-cell identity, apoptosis, loss of β-cell mass, and diabetes. Furthermore, β-cell "glucolipotoxicity" can be prevented by deletion of ChREBPβ. Moreover, ChREBPβ-mediated cell death is …

Mirna Expression Is Increased In Serum From Patients With Semantic Variant Primary Progressive Aphasia, Maria Serpente, Laura Ghezzi, Chiara Fenoglio, Francesca R Buccellato, Giorgio G Fumagalli, Emanuela Rotondo, Marina Arcaro, Andrea Arighi, Daniela Galimberti

2020-Current year OA Pubs

Primary progressive aphasia (PPA) damages the parts of the brain that control speech and language. There are three clinical PPA variants: nonfluent/agrammatic (nfvPPA), logopenic (lvPPA) and semantic (svPPA). The pathophysiology underlying PPA variants is not fully understood, including the role of micro (mi)RNAs which were previously shown to play a role in several neurodegenerative diseases. Using a two-step analysis (array and validation through real-time PCR), we investigated the miRNA expression pattern in serum from 54 PPA patients and 18 controls. In the svPPA cohort, we observed a generalized upregulation of miRNAs with miR-106b-5p and miR-133a-3p reaching statistical significance (miR-106b-5p: 2.69 …

On The Properties Evolution Of Eco-Material Dedicated To Manufacturing Artificial Reef Via 3d Printing: Long-Term Interactions Of Cementitious Materials In The Marine Environment, F Boukhelf, N Sebaibi, M Boutouil, Ai Yoris-Nobile, E Blanco-Fernandez, D Castro-Fresno, C Real-Gutierrez, Rjh Herbert, S Greenhill, B Reis, Jn Franco, Mt Borges, I Sousa-Pinto, Der Linden P Van, Ob Gómez, Hs Meyer, E Almada, R Stafford, V Danet, J Lobo-Arteaga, M Tuaty-Guerra, Alice Hall

School of Biological and Marine Sciences

This paper deals with the evolution monitoring of biomass colonization and mechanical properties of 3D printed eco-materials/mortars immersed in the sea. Measurements of tensile strength, compressive strength, and Young’s modulus were determined on samples deployed along the Atlantic coast of Europe, in France, United Kingdom, Spain, and Portugal. The samples were manufactured using 3D printing, where six mix designs with a low environmental impact binder were used. These mortars were based on geopolymer and cementitious binders (Cement CEM III), in which sand is replaced by three types of recycled sand, including glass, seashell, and limestone by 30%, 50%, and 100% …

The Gut Microbiome Variability Of A Butterflyfish Increases On Severely Degraded Caribbean Reefs, Friederike Clever, Jade M. Sourisse, Richard F. Preziosi, Jonathan A. Eisen, E. Catalina Rodriguez Guerra, Jarrod J. Scott, Laetitia G.E. Wilkins, Andrew H. Altieri, W. Owen Mcmillan, Matthieu Leray

School of Biological and Marine Sciences

AbstractEnvironmental degradation has the potential to alter key mutualisms that underlie the structure and function of ecological communities. How microbial communities associated with fishes vary across populations and in relation to habitat characteristics remains largely unknown despite their fundamental roles in host nutrition and immunity. We find significant differences in the gut microbiome composition of a facultative coral-feeding butterflyfish (Chaetodon capistratus) across Caribbean reefs that differ markedly in live coral cover (∼0–30%). Fish gut microbiomes were significantly more variable at degraded reefs, a pattern driven by changes in the relative abundance of the most common taxa potentially associated with stress. …

University Of Memphis Magazine, 2000 Fall

University of Memphis Magazine

Annual Report of the President.

Cover Story, "Celebrate The Rudi E. Scheidt School of Music" by Elizabeth Walker

The University's music program has a new name and an exciting future, thanks to a gift from Rudi Scheidt.

Also featured, "Celebrate Alumna Tina Santi Flaherty" by Benita Whitehorn

This alumna is giving back to her alma mater through the Legacy Scholarship campaign.

Identification Of Microorganisms From The Depths Of Wind Cave, Abbie Bangs, Justin Peters Ph.D., Joshua Sebree Ph.D.

Summer Undergraduate Research Program (SURP) Symposium

During 2022, samples were collected at Wind Cave National Park on three different trips. As the team goes deeper and deeper into the cave, the goal is to actively trace the types of microorganisms (fungi, bacteria, and archaea) throughout the cave. The process to obtain species level identification of these samples utilizes PCR amplification of different sections of their genomic DNA followed by sequencing analysis. An initial phylogenetic tree showing relatedness of the identified microorganisms is presented.

Geoenvironmental Implications On Food Sovereignty - Meskwaki Settlement, Tama County, Iowa, Lindsey Hubbell, Chad Heinzel Ph.D., Christina Blackcloud, Luke Kapayou, Avis Bear-Bass

Summer Undergraduate Research Program (SURP) Symposium

Native American culture demonstrates a spiritual relationship to food, land, and Earth. As opposed to European traditions valuing private property and exploiting the Earth for profit, Native American tradition believes the Earth is owned by no one; food and nourishment from it are a gift for all to take only as needed. The Meskwaki Nation originated around the Great Lakes but was removed to Tama County, Iowa. It is derived from the words “Meskwa” meaning “red” and “aki” meaning “Earth”. This Red Earth nation has initiated a Food Sovereignty program to pass along traditional growing and food preparation practices to …

Why Do Effective Science Teachers Persist?: A Mixed Methods Approach Exploring Post-Induction Effective Science Teachers' Experiences, Molly Ella Ramker, William Raymond Lange, Jesse Wilcox Ph.D., Dori Clausen

Summer Undergraduate Research Program (SURP) Symposium

Secondary science teachers have been leaving the field at an increasing rate in recent years. While much is known about science teacher attrition, less is known about science teacher persistence. The purpose of this study was to identify effective post-induction science teachers and analyze why they persist. This study was conducted using a mixed-methods approach including the Local Systemic Change Classroom Observation Protocol (LSC-COP) to generate a quantitative measure of science teaching effectiveness, along with using a phenomenological approach to investigate the experiences of effective science teachers who have stayed in the field.The median and mode of the LSC-COP capsule …

Evaluation Of Methods To Extract Genetic Material From Wild Bees, Brody Jack, Mila Haynes, Ai Wen Ph.D.

Summer Undergraduate Research Program (SURP) Symposium

Genetic studies on bees are essential to the understanding of the genetic and species diversity of bees, as well as general prairie health. Diversification of species and genetics are in decline, this means a decline in overall prairie health is inevitable. The University of Northern Iowa has ongoing studies looking into the health of prairies as well as the bee population, with a need for an understanding of how to properly store and extract genetic material from wild bees. We examined the concentration of DNA and fragment size shown in a gel from the bees that were killed using two …

Exploring Microbes At Wind Cave As An Analog For Exobiological Environments Off Earth, Abby K. Sliwiniski, Emma W. Pellegrino, Nicole Geerdes, Marek K. Sliwinski

Summer Undergraduate Research Program (SURP) Symposium

Subterranean environments on Earth serve as an analog for the study of microbes on other planets. This has become an active area of research with the discovery of exoplanets. To learn about the microbial species living in Wind Cave, we are comparing methods to sample environmental DNA because most microbes cannot be cultivated using standard laboratory methods. We are then probing the environmental DNA with broad primers that are designed to amplify most life and narrower primers such as those specific to the domain Archaea. Of the methods compared, the Qiagen DNeasy Powerbiofilm kit produced the purest template as measured …

Comparison Of Plant Richness And Density In Crp-42 Fields Between 2018 And 2022, Liz Wilgenbusch, Ai Wen Ph.D.

Summer Undergraduate Research Program (SURP) Symposium

Recently, the number of pollinators have decreased dramatically throughout the United States. Pollinators play an important role in food production with around ⅓ of the world’s food crops being dependent on pollinators. Providing a high-forage habitat for pollinators is a proposed solution to combat their decline. In the upper Midwest United States, the Conservation Reserve Program (CRP) helps protect pollinator habitats by providing farmers with annual payments to retire their old farmland. The purpose of this study was to compare plant density and richness in CRP fields between year 3 and year 7 post planting to find trends in the …

Developing Methods To Assess The Role Of Lumbricus Terrestris On Seed Predation In Prairie Restoration [Poster], Jacey Meier, Laura L. Jackson Ph.D.

Summer Undergraduate Research Program (SURP) Symposium

Much of Iowa and the midwest used to be covered in tallgrass prairie– now only a small percentage of it remains. Many prairie restoration efforts to revitalize prairie lands are in place, but native prairie seed prices are extremely high. In addition, seedling establishment rates of native prairie seed are low. There are many events that can occur to prevent a seed from germinating into a seedling. One of those events is seed predation (or granivory). Seed predation is when seeds are used as a primary food source for animals. Granivores that commonly come to most minds include mice, squirrels, …

Assessing Methods For Enhancing Monarch Habitat In Re-Enrolling Crp Sites, Eva Van De Mortel, Tristan Murphy, Laura L. Jackson Ph.D.

Summer Undergraduate Research Program (SURP) Symposium

Over the last 30 years, monarch butterflies and their habitats have been in dramatic decline. Land enrolled in the Conservation Reserve Program (CRP) is one of the greatest resources available to increase monarch population as it has the largest amount of space available for monarch habitat. However, some fields have lost the nectar plants and milkweeds necessary for monarch habitat. This study, asked how to best suppress vegetation in re-enrolling CRP land so that overseeded forbs have a better chance of survival? Vegetation surveys from 6 different sites in northeastern Iowa and results from 2021 to 2022 were compared. We …

Using Environmental Dna (Edna) To Assess Pollinator Communities In Cedar Valley, Mila Haynes, Brody Jack, Ai Wen Ph.D.

Summer Undergraduate Research Program (SURP) Symposium

Tracking biological activity in Iowa prairies can prove difficult with such high levels of biodiversity. However, using environmental DNA (eDNA) collected from prairie flowers can provide integral information about the insects that pollinate various plants.

When bees land on flowers, they shed cells and leave trace amounts of their DNA behind. After extracting the DNA from these flowers using the Qiagen DNeasy Extraction method, the samples are then mixed with B10 primer. This primer allows only the bee DNA to be targeted once the samples are put through a Polymerase Chain Reaction (PCR).

The purpose of this study is to …

Curating A Global Collection Of Grapsoid Crabs For The American Natural History Museum, Nyc, Taylor Pruisman, Amber Finke, Carl Thurman Ph.D.

Summer Undergraduate Research Program (SURP) Symposium

Curation is a powerful tool when accessing information about specialized collections. Many researchers that use specimens borrowed from other institutions often find the supporting information insufficient. Over the last two years, a large collection of preserved grapsoid crabs was received from Frank H. Barnwell, Ecology, Evolution, and Behavior, University of Minnesota-Twin Cities.The collection of land crabs has undergone an extensive curation process done by University of Northern Iowa undergraduates. The curation process included identifying species, locating pin points, counting of sexes, rehousing and producing new labels. The specimens were sorted by their species, counted by gender, and their collection locations …

Globalizing Sexual Violence: Charting A Path For Future Research, Adam J. Whiteside

Kaleidoscope: A Graduate Journal of Qualitative Communication Research

Sexual violence is a global issue with devastating consequences. Existing research primarily focuses on its prevalence globally or how countries understand sexual violence. Additionally, media reports often misrepresent sexual violence, fail to capture its complexities, and ignore larger gender issues at play. This article synthesizes extant research using a feminist intersectional approach to provide a basis for comparing how sexual violence is discursively constructed globally. More specifically, how historical, cultural, and socioeconomic discourses underscore the perpetration and media framing of sexual violence. To this end, I reviewed 49 articles on sexual violence in India and South Africa with an eye …

Chronic Obstructive Pulmonary Disease Pathophysiology, Alex Thompson

Nursing Student Class Projects (Formerly MSN)

This poster presentation overviews the pathophysiologic process and accompanying disease characteristics associated with Chronic Obstructive Pulmonary Disease (COPD). COPD is a leading cause of mortality worldwide. Studies suggest that its incidence will only increase in the future. COPD risk factors include smoking tobacco, environmental chemical/pollution irritants, and genetic predisposition. Smoking is the most common cause of COPD, and cessation can improve patient outcomes drastically. This chronic obstructive pulmonary disease overview discusses the importance of knowledge of COPD, signs, symptoms, pathophysiology, peri-operative management, treatments, and prevention.

Morphological Effects Of Simulated Low-Gravity In Neurospora Crassa, Maya Nietzel, Leanna Steverson

Summer Interdisciplinary Research Symposium

The control of branching in Neurospora crassa has been studied under numerous environmental conditions. Here we present the observations of N. crassa morphology in simulated low-gravity. A wildtype strain was grown on solid and liquid minimal media. Control samples were left on a lab bench to grow while experimental samples were placed into a clinostat. After two days the samples were observed under microscopes at different magnifications, then the edges of growth were photographed. The images were used to compare growth patterns, density, branch intervals, and branch frequency. In both types of media, the clinostat samples appeared to grow in …

Potential Psychoactive Effects Of Microalgal Bioactive Compounds For The Case Of Sleep And Mood Regulation: Opportunities And Challenges, Bozena Mccarthy, Graham O’Neill Dr, Nissreen Abu-Ghannam Prof.

Articles

Sleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being. A major drawback of conventional treatments is the wide range of undesirable side-effects typically associated with benzodiazepines and antidepressants, which can be more debilitating than the initial disorder. It is therefore valuable to explore the efficiency of other remedies for complementarity and synergism with existing conventional treatments, leading to possible reduction in undesirable side-effects. This review …

Arsr Family Regulator Msmeg_6762 Mediates The Programmed Cell Death By Regulating The Expression Of Hnh Nuclease In Mycobacteria, Xiangke Duan, Xue Huang, Junqi Xu, Xue Li, Jingjing Niu, Xiaoli Du, Xiaoyu Wang, Jiang Li, Michael Kelly, Jiaohan Guo, Ke Zhang, Yu Huang, Biao Kan, Jianping Xie

Biology Student Work

Programmed cell death (PCD) is the result of an intracellular program and is accomplished by a regulated process in both prokaryotic and eukaryotic organisms. Here, we report a programed cell death process in Mycobacterium smegmatis, an Actinobacteria species which involves a transcription factor and a DNase of the HNH family. We found that over-expression of an ArsR family member of the transcription factor, MSMEG_6762, leads to cell death. Transcriptome analysis revealed an increase in the genes’ transcripts involved in DNA repair and homologous recombination, and in three members of HNH family DNases. Knockout of one of the DNase genes, MSMEG_1275, …

Sex Differences In The Genetic Architecture Of Cognitive Resilience To Alzheimer's Disease., Jaclyn M Eissman, Logan Dumitrescu, Emily R Mahoney, Alexandra N Smith, Shubhabrata Mukherjee, Michael L Lee, Phoebe Scollard, Seo Eun Choi, William S Bush, Corinne D Engelman, Qiongshi Lu, David W Fardo, Emily H Trittschuh, Jesse Mez, Catherine C Kaczorowski, Hector Hernandez Saucedo, Keith F Widaman, Rachel F Buckley, Michael J Properzi, Elizabeth C Mormino, Hyun Sik Yang, Theresa M Harrison, Trey Hedden, Kwangsik Nho, Shea J Andrews, Douglas Tommet, Niran Hadad, R Elizabeth Sanders, Douglas M Ruderfer, Katherine A Gifford, Xiaoyuan Zhong, Neha S Raghavan, Badri N Vardarajan, Margaret A Pericak-Vance, Lindsay A Farrer, Li San Wang, Carlos Cruchaga, Gerard D Schellenberg, Nancy J Cox, Jonathan L Haines, C Dirk Keene, Andrew J Saykin, Eric B Larson, Reisa A Sperling, Richard Mayeux, Michael L Cuccaro, David A Bennett, Julie A Schneider, Paul K Crane, Angela L Jefferson, Timothy J Hohman

Faculty Research 2022

Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer's disease neuropathology may uncover novel therapeutic targets to treat Alzheimer's disease. It is well established that there are sex differences in response to Alzheimer's disease pathology, and growing evidence suggests that genetic factors may contribute to these differences. Taken together, we sought to elucidate sex-specific genetic drivers of resilience. We extended our recent large scale genomic analysis of resilience in which we harmonized cognitive data across four cohorts …

Qtlviewer: An Interactive Webtool For Genetic Analysis In The Collaborative Cross And Diversity Outbred Mouse Populations, Matthew J Vincent, Isabela Gerdes Gyuricza, Gregory R Keele, Daniel Mario Gatti, Mark P. Keller, Karl W. Broman, Gary Churchill

Faculty Research 2022

The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50¬†M known genetic variants, which makes them ideal tools for mapping genetic loci that regulate phenotypes, including physiological and molecular traits. Mapping quantitative trait loci requires statistical and computational training, which can present a barrier to access for some researchers. The QTLViewer software allows users to graphically explore Collaborative Cross and Diversity Outbred quantitative trait locus mapping and related analyses performed through the R/qtl2 package. Additionally, the QTLViewer website serves as a repository for published Collaborative Cross …

2022 Summer Undergraduate Research Program, University Of Northern Iowa. Sumer Undergraduate Research Program.

Summer Undergraduate Research Program (SURP) Symposium Programs

The program for the Summer Undergraduate Research Symposium of the College of Humanities, Arts and Sciences.

Identification And Characterization Of A Novel Axon Guidance Receptor In The Eye-Specific Visual Projection, Maya Dunson, Masaru Nakamoto

Summer Interdisciplinary Research Symposium

Correct functioning of the nervous system critically depends on the formation of the precise neuronal network. In mammals with binocular vision, axons of retinal ganglion cells from the right and left eyes project to different domains of the lateral geniculate nucleus in the thalamus (Retinogeniculate projection). The eye-specific visual projection provides the anatomical basis for disparity-based stereopsis (perception of depth). However, the molecular mechanism that regulates the eye-specific visual projection is not well understood. Nell2 (neural epidermal growth factor (EGF)-like-like 2) is an extracellular glycoprotein that is predominantly expressed in the nervous system. Our lab has previously shown that Nell2 …

Human Hepatocyte 4-Acetoxy- N, N-Diisopropyltryptamine Metabolite Profiling By Reversed-Phase Liquid Chromatography Coupled With High-Resolution Tandem Mass Spectrometry, Sara Malaca, Marilyn A Huestis, Leonardo Lattanzio, Luigi T Marsella, Adriano Tagliabracci, Jeremy Carlier, Francesco P Busardò

College of Health Professions Faculty Papers

Tryptamine intoxications and fatalities are increasing, although these novel psychoactive substances (NPS) are not controlled in most countries. There are few data on the metabolic pathways and enzymes involved in tryptamine biotransformation. 4-acetoxy-N,N-diisopropyltryptamine (4-AcO-DiPT) is a synthetic tryptamine related to 4-hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT), 4-acetyloxy-N,N-dipropyltryptamine (4-AcO-DPT), and 4-acetoxy-N,N-dimethyltryptamine (4-AcO-DMT). The aim of this study was to determine the best 4-AcO-DiPT metabolites to identify 4-AcO-DiPT consumption through human hepatocyte metabolism and high-resolution mass spectrometry. 4-AcO-DiPT metabolites were predicted in silico with GLORYx freeware to assist in metabolite identification. 4-AcO-DiPT was incubated with 10-donor-pooled human hepatocytes and sample analysis was performed with reversed-phase liquid …

61st Annual Rocky Mountain Conference On Magnetic Resonance

Rocky Mountain Conference on Magnetic Resonance

Final program, abstracts, and information about the 61st annual meeting of the Rocky Mountain Conference on Magnetic Resonance, co-endorsed by the Colorado Section of the American Chemical Society and the Society for Applied Spectroscopy. Held in Copper Mountain, Colorado, July 25-29, 2022.

A Review Of Host Plants For The Tortricid Tribe Grapholitini, With A Synopsis Of Host Utilization By Genus (Lepidoptera: Tortricidae), John W. Brown

Insecta Mundi

A database of larval host plants for the tortricid tribe Grapholitini (Lepidoptera: Tortricidae: Ole­threutinae) is presented, and larval hosts are summarized for each genus. Food plants have been reported for over 400 of the approximately 1,644 described species of Grapholitini. Of the 81 genera currently as­signed to the tribe, at least one larval host has been reported for 51. Ninety-seven different plant families have been reported at least once for a species of Grapholitini, with the greatest number of grapholitines recorded from Fabaceae (168 species), followed by Fagaceae (43 species), Pinaceae (43), Sapindaceae (36), Rosaceae (30), Asteraceae (30), Euphorbiaceae (15), …

Synopsis Of The Tribe Amarotypini In New Zealand (Coleoptera: Carabidae), André Larochelle, Marie-Claude Larivière

Insecta Mundi

The tribe Amarotypini (Coleoptera: Carabidae: Migadopinae) is revised for New Zealand. Three genera and fourteen species are recognized.

Two genera and thirteen species are described as new: Amarophilus Larochelle and Larivière new genus, Amarophilus lomondensis Larochelle and Larivière new species, Amarophilus otagoensis Larochelle and Larivière new species, Amarophilus rotundicollis Larochelle and Larivière new species, Amarophilus wanakensis Larochelle and Larivière new species, Amarotypus fiordlandensis Larochelle and Larivière new species, Amarotypus glasgowensis Larochelle and Larivière new species, Amarotypus murchisonorum Larochelle and Larivière new species, Amarotypus simoninensis Larochelle and Larivière new species, Amarotypus takaheensis …