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Quantifying The Dosimetric Impact Of Target Margins In The Oligometastatic Setting, Jessica E. Strang

Masters Projects

Introduction

With advancements in cancer treatment therapies, patients are living longer with oligometastatic disease. These patients may have multiple targets and may be treated in a single isocenter to reduce overall treatment time. However, the most considerable risk of treating multiple lesions in a single isocenter is a geometric miss. It can be challenging to perform daily alignment of multiple lesions creating a need to prioritize one lesion alignment over others or abort treatment.

Methods

This study quantified the dosimetric impact of total lung exposure as the planning target volume (PTV) margin incrementally increased for multiple intrathoracic lesions.

The analysis …

Determination Of Atlantic Shortfin Mako Shark (Isurus Oxyrinchus) Population Genetic Structure And Comparison Of Mitogenomic Markers, Marissa Mehlrose

All HCAS Student Capstones, Theses, and Dissertations

This study provides the first genomics-level, population structure and genetic diversity assessment of the shortfin mako (Isurus oxyrinchus) shark. The assessments were based on mitogenome sequences from makos distributed throughout the Atlantic Ocean, with Pacific mako mitogenomes used as a comparative outgroup. In addition to complete mitogenome-based analyses, I assessed individual mitochondrial coding gene and non-coding (Control Region) sequences for their comparative resolution properties as markers for revealing matrilineal population structure and genetic diversity. Sequencing of 125 makos in the western and eastern Atlantic across northern and southern hemispheres yielded 92 complete mitogenomes (16,698-16,702 bp) and 33 partial …

Myc Sensitises Cells To Apoptosis By Driving Energetic Demand, Joy Edwards-Hicks, Kevin Cho, Gary J Patti, Et Al

2020-Current year OA Pubs

The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sensitisation to apoptosis may be due to imbalance of metabolic/energetic supply and demand. Here we show that MYC elevates global transcription and translation, even in the absence of glutamine, revealing metabolic demand without corresponding supply. Glutamine withdrawal from MRC-5 fibroblasts depletes key tricarboxylic acid (TCA) cycle metabolites and, in combination with MYC activation, leads to AMP accumulation and nucleotide …

A Mechanical And Finite Element Analysis Of Bone Screw Thread Design, Timothy H. Cook

Theses and Dissertations

This paper will seek to evaluate results obtained from mechanical testing and computational analysis to determine the efficacy of new thread designs for bone screws in their various applications and uses in surgical treatments. These new thread designs will be tested against the market standard buttress thread and any resulting trends will be analyzed.

Four different thread designs were tested in 90 degree cyclic loading and then subsequently an axial pullout test. The parameters of interest from these tests such as peak to peak displacement over cycle and axial load versus axial displacement were recorded. These four designs were the …

Travel Behavior And Subjective Well-Being: Effects Of Travel, Activity, And Personal Factors, Jacquelyn O. Erinne

Theses and Dissertations

The overarching goal of this dissertation is to examine the complex trip-, activity-, and personal-level factors impacting individuals’ well-being. This is achieved through fulfilling three research objectives. The first objective examines the fluctuation of happiness induced by the influences of daily trip and activity factors. The second objective examines the sensitivity of affective well-being to trip and activity duration. The third objective evaluates the gender differences in trip- and activity-induced well-being. Three notable findings are discerned using trip and activity episodes as well as self-reported well-being of 357 participants collected by the Daynamica smartphone application in Minneapolis-St. Paul metropolitan area …

Identifying Pneumococcal Proteins That Elicit An Iga Response, Amber Travis

Theses and Dissertations

Streptococcus pneumoniae is an asymptomatic colonizer of the upper respiratory tract as well as an opportunistic pathogen. Colonization is prerequisite to causing disease in a host, and it often involves formation of biofilms. There are currently two vaccines available against pneumococcus, both of which focus on preventing invasive disease by targeting the polysaccharide capsule of the most invasive serotypes. We hypothesized that by using membrane proteins expressed during the biofilm state, we can formulate an effective vaccine against colonization which would lead to an overall decrease in disease incidence. To do this, we selected protein candidates expressed during biofilm growth …

Novel 3d Bench Top Model For Vascular Calcification Research, Ursla-Marie K. Offiah

Theses and Dissertations

Cardiovascular disease is the leading cause of non-communicable disease in the whole world killing 17 million people in 2012. Among the many vascular diseases is vascular calcification (VC) which is the mineral build up in the walls of blood vessels. Medial calcification is the plaque buildup in the medial layer of the blood vesicle that is characterized by arterial stiffness and high blood pressure. Current calcification research involves two dimensional (2D) lab methods such as flat petri dishes to investigate the mechanism that causes and inhibits vascular calcification. Research has shown that the use of three-dimensional (3D) models can be …

Evaluating Non-Invasive Environmental Methods For Detecting Tropical African Pangolin Species To Inform Conservation Actions, Ichu Godwill Ichu

Theses and Dissertations

Tropical African pangolin species are threatened throughout their range due to habitat loss and illegal take. Limited knowledge on distribution has rendered conservation efforts challenging. Methods commonly used for other wildlife species need to be tested for each pangolin species as each has variable ecologies requiring specific detection and monitoring techniques. This thesis evaluates the efficacy of two non-invasive environmental methods for detecting tropical African pangolin species, and consists of two complementary studies; a proof of concept study using soil sourced eDNA from a white-bellied pangolin enclosure in the Columbus Zoo, Ohio, to detect the species, and a field study …

(Re)Constructing Homescapes: “Archaeological Remote Sensing” And Ground-Truthing Of The Walker Place Homestead At Spirit Hill Farm, Tate County, Mississippi, Gabriel Griffin

Theses and Dissertations

This thesis focuses on an early nineteenth-century homestead known as the Walker Place homestead at Spirit Hill Farm in northern Mississippi. The goal of this thesis is to conduct a ground-penetrating radar (GPR) and shovel test survey to explore how changing landscapes simultaneously (re)create and destroy senses of place or Homescapes. Homescapes have received little attention in the field of archaeology and have not been applied to Euro-American Homescapes. I apply this theoretical construct in a novel way as a venture to further develop an avenue in archaeology to be collaborative and understand the past in a way that accurately …

Ex Vivo Biomechanical Comparison Of A Novel Compression Screw Fastener And Traditional Ao Cortical Bone Screw For Fixation Of A Simulated Slab Fracture In The Equine Third Carpal Bone, Allison Salinger

Theses and Dissertations

Frontal plane slab fractures account for the majority of third carpal bone (C3) fractures in performance horses. Treatment is stabilization with an AO cortical screw. Complications are fragment splitting, fragment spinning, and irritation of dorsal soft tissue structures. A novel, headless, cannulated screw with interlocking threads (the Headless Compression Screw Fastener, HCSF) has been developed to resist multidirectional forces. Simulated C3 slab fractures were created in nine paired equine carpi. HCSF or AO cortical screws were loaded in shear to failure. Stiffness, maximum load to failure, and yield load was assessed in linear mixed models. No significant difference was detected …

Methods And Tools To Improve Performance Of Plant Genome Analysis, Drew Ferrell

Theses and Dissertations

Multi -omics data analysis and integration facilitates hypothesis building toward an understanding of genes and pathway responses driven by environments. Methods designed to estimate and analyze gene expression, with regard to treatments or conditions, can be leveraged to understand gene-level responses in the cell. However, genes often interact and signal within larger structures such as pathways and networks. Complex studies guided toward describing dynamic genetic pathways and networks require algorithms or methods designed for inference based on gene interactions and related topologies. Classes of algorithms and methods may be integrated into generalized workflows for comparative genomics studies, as multi -omics …

The Level Of Burnout And Job Satisfaction Among Mississippi Agriculture Educators And The Potential Level Of Impact From The Covid-19 Pandemic, Anna Hollis

Theses and Dissertations

Many states across the country have felt the impact of a nationwide teacher shortage. Specifically, the state of Mississippi has experienced a shortage of certified agricultural education teachers. Unfortunately, during a time, a novel virus (Coronavirus or COVID-19) swept the entire world and shook the academic world to its core. Like the majority, educators were encouraged to adopt a variety of approaches to better flow with the changes in their “normal” routines. Many researchers have suggested that teachers are leaving education due to little resources, recognition, and high job demands, which correlates to poor job satisfaction and symptoms of burnout. …

Effect Of Cover Crops, Grazing And Tillage Practices On Soil Microbial Community Composition, Function, And Soil Health In East Central Mississippi Soybean Production System., Namita Sinha

Theses and Dissertations

Integrating crop and livestock is being considered to improve soil health by carbon sequestration. A two-year study (2019-2021) at CPBES in Newton, MS was aimed to evaluate soil microbial diversity in the warm, humid regions, specifically southeastern USA. Amplicons targeting bacterial 16S rRNA genes and fungal ITS2 regions were sequenced. Taxonomic assignment and microbial diversity characterization were performed using QIIME2^®. Soil fungal diversity showed significant differences (alpha diversity, p = 0.031 in yr. 2020 and beta diversity, p = 0.037 in yr. 2021). Canonical Correspondence Analysis (CCA) and Mantel test showed significant influence on fungal diversity due to …

The Effect Of Maternal Melatonin Supplementation During Mid To Late Gestation On Offspring Muscle Growth And Development In Swine, Thomas Warren Dobbins

Theses and Dissertations

Melatonin is a neuroendocrine hormone most often associated with circadian rhythms, but also has antioxidant and vasodilative properties. Through these properties, exogenous melatonin supplementation has been shown to increase both fetal and postnatal parameters in livestock species, however no research has been performed in swine. This project was split into a prenatal and postnatal study, wherein sows were supplemented from approximately gestational day 38 to 100 before undergoing a terminal hysterectomy for the prenatal portion, and from gestational day 60 to farrowing. Melatonin increased fetal morphometrics in a seasonal dependent manner, where fetuses from melatonin supplemented sows had increased measurements …

Assessing Virtual Free-Choice Agricultural Learning: A Mixed Methods Approach, Richard John Kennedy

Theses and Dissertations

Since the mid-19th century, agricultural museums and living history sites, first in Scandinavia and then in the United States and Canada, have provided historical, cultural, and, sometimes, scientific information about farming to visitors. Many of these visitors have been school children on field trips. Assessment of this learning, however, has been scant, particularly within the free-choice style inherent in these types of educational venues. At the same time, assessment of free-choice learning, often analyzed through the Contextual Model of Learning (Falk & Dierking 2000), has taken place at educational sites like zoos, natural history museums, and science centers. This study, …

Incorporating Follicle Stimulating Hormone To Stimulate Multiple Corpora Lutea For Embryo Transfer In Beef Cattle, Bryan Carter

Theses and Dissertations

Assisted reproductive technologies, such as estrus synchronization and embryo transfer, can aid producers in improving genetics by increasing the number of progeny produced from elite females. The success of embryo transfer is dependent on a viable, competent embryo and a recipient with a receptive uterine environment. Follicular development and luteinization are pertinent for the recipient to establish a functional corpus luteum (CL) that can produce adequate concentrations of progesterone (P4) and provide a uterine environment conducive for the establishment of pregnancy. The objective of this study was to determine if exogenous follicle stimulating hormone (FSH), would increase the number of …

Effects Of Anthropogenic Global Change On A Grassland Prairie Community, Carter Wolff

Theses and Dissertations

Anthropogenic global change is altering food web dynamics. Global change comprises factors, like temperature, sound, light and more. In this dissertation, I evaluate how two factors, sound and temperature, alter prairie communities. In Chapter 1, I test if sound influences grasshopper respiration rate, thereby altering diet. Some sound frequencies increased grasshopper respiration rate while others decreased respiration rate. Frequencies that elevated respiration rate led to grasshoppers consuming more carbohydrate-rich foods compared to protein-rich foods. This diet change stems from a carbon deficit due to increased respiration rate and could act as a mechanism by which sound pollution indirectly alters plant …

Phenotypic Evaluation Of Energycane (Saccharum Spp.) Genotypes In Northcentral Mississippi, Wyatt Armistead Eason

Theses and Dissertations

As fossil fuel supplies decrease and concerns of climate change increase, the search for alternative sources of fuel has pushed biomass crops to the forefront of discussion. Saccharum spontaneum readily hybridizes with commercial sugarcane and lends cold tolerance and greater yields to the hybrid progeny, called energycane. Twenty genotypes were tested against an energycane variety (Ho 02-113) as a control. Two locations were tested: the HH Leveck Animal Research Center (planted in 2019), and the Bearden Dairy Research Center (planted in 2020). The Bearden Dairy Research Center yielded significantly higher than the HH Leveck Animal Research Center regarding dry matter …

Classification Models For 2,4-D Formulations In Damaged Enlist Crops Through The Application Of Ftir Spectroscopy And Machine Learning Algorithms, Benjamin Blackburn

Theses and Dissertations

With new 2,4-Dichlorophenoxyacetic acid (2,4-D) tolerant crops, increases in off-target movement events are expected. New formulations may mitigate these events, but standard lab techniques are ineffective in identifying these 2,4-D formulations. Using Fourier-transform infrared spectroscopy and machine learning algorithms, research was conducted to classify 2,4-D formulations in treated herbicide-tolerant soybeans and cotton and observe the influence of leaf treatment status and collection timing on classification accuracy. Pooled Classification models using k-nearest neighbor classified 2,4-D formulations with over 65% accuracy in cotton and soybean. Tissue collected 14 DAT and 21 DAT for cotton and soybean respectively produced higher accuracies than the …

The Effects Of Moderate And High Temperatures On Growth, Metabolism, And Blood-Oxygen Affinity In Ictalurus Spp., Brandon Gerhart

Theses and Dissertations

Despite the growing use of hybrid catfish (Ictalurus furcatus × I. punctatus) in aquaculture, few studies have investigated the comparative effects of temperature on physiological performance with other cultured catfish. Therefore, growth, metabolism, and blood-oxygen affinity of blue (I. furcatus), channel (I. punctatus), and hybrid catfish were compared at moderate (23°C) and high (33°C) water temperatures. Channel catfish had the greatest growth and were in better condition compared to blue and hybrid catfish. Hybrid catfish standard metabolic rates did not differ from blue or channel catfish, while hybrid catfish had higher maximum metabolic rates, …

Nondestructive Assessment Of Flexural And Tensile Properties For Southern Pine Structural Lumber, Marly Gabriela Carmona Uzcategui

Theses and Dissertations

The flexural and tensile properties of visually graded southern yellow pine lumber were modeled. Longitudinal and transverse vibration techniques and proof-loading bending tests were used to assess the flexural and tensile properties of southern pine lumber. The properties evaluated were dynamic modulus of elasticity (dMOE), static modulus of elasticity (E_b), tension modulus of elasticity (E_t), and ultimate tensile stress (UTS). The tensile properties were evaluated in the direction parallel to the grain. This study presents the results of tests conducted on No. 2 2 × 6 and 2 × 10 southern pine lumber of two different …

Experiments To Mitigate Flow Recirculation In A Closed Anechoic Chamber Using Mesh Screens As Turbulence Suppressors, Tori Kay Wolverton

Theses and Dissertations

The desire to gather acoustic data of a propeller in simulated hover without environmental effects is met with the challenge of recirculating flow in a closed anechoic chamber. Flow recirculation in an anechoic chamber is not ideal because the effects of it being ingested by the rotor cause unsteady loadings on the propeller. This unsteady loading causes vortex noise from the turbulence introduced by the recirculation of the flow. The aim is to study the acoustic signature of a propeller separate from external factors and engine noise. Two different propellers with three different screen combinations were tested in a closed …

Beyond The Pta: Mothering Work And Women's Education Activism In The Deep South, Emily L. Tingle

Theses and Dissertations

It has long been established that women play unique roles within schools, volunteerism, and school-based community work (Griffith and Smith 2005; Calarco 2020; Lewis and Diamond 2015; Posey-Maddox 2014). Additionally, research suggests that the work done surrounding the institution of education primarily falls on mothers (Griffith and Smith 2005; Haley-Lock and Posey-Maddox 2016; Lareau 2000; Lareau 2011). However, little research has been done that explores how gender dynamics play out in education activism that lies outside of schools. This study seeks to understand how women view gendered expectations of mothering work in regard to education and if/how they perceive that …

Natural Capital Value Of Fisheries Under Environmental Stressor: A Case Of Blue Crab Under Hypoxia In The Gulf Of Mexico, Shelby Leigh Brewer

Theses and Dissertations

Environmental threats to fisheries are a rising concern for fishery managers. Gulf of Mexico hypoxia is particularly concerning. In order to properly manage Gulf fisheries, the sustainability of species stock and its natural capital values should be analyzed. As an empirical effort, I use blue crab in Louisiana waters as a case study to build a bioeconomic model of blue crab under hypoxia. I apply the natural capital valuation approach to estimate the blue crab value function under hypoxia in order to assess blue crab sustainability. I find that blue crab management in Louisiana under hypoxia is not sustainable, being …

Assessing The Functional Impacts Of Acquired Syphilis In Industrial England, Cassandra Marie Seda Degaglia

Theses and Dissertations

This work identifies and describes pathological skeletal changes associated with and attributable to acquired syphilis and which potentially caused functional impairment within eleven skeletal individuals recovered from five industrial-era London cemeteries. In eight (72.73%), functional impairment was likely or very likely, based on type and distribution of lesions across their skeleton. These impairments likely impacted the individuals’ ability to engage in various forms of physical activity, potentially limiting their economic potential. These results expand our still highly limited understanding of syphilis’s functional impacts within past populations, especially within industrial-era societies, querying longstanding characterizations of tertiary gummatous involvement as benign, while …

Utilizing Unmanned Aerial Systems To Sample Insects In Soybean, Marvin Merkl

Theses and Dissertations

To overcome some limitations of manual insect sampling in soybeans, an unmanned aerial vehicle (UAV) sampling platform was developed that could collect insects in a sweep net attached to the bottom of a UAV. Before this UAV sampling platform can be used to make management decisions, correlations with manual sweep net and/or drop cloth sampling methods are needed. This will allow action thresholds for the various pests to be calculated for the UAV sampling platform. To make the correlations, 87 soybean fields were sampled during 2020 and 2021 with each of 4 sampling methods, a UAV travelling 50-m, the same …

Inosine 5’- Monophosphate Derived Umami Flavor Intensity Of Beef Determination By Electrochemistry And Chromatography, Kezia Virellia To

Theses and Dissertations

The umami sensation contributes to beef flavor and acceptability. Inosine 5’- monophosphate (IMP) was the most abundant nucleotide in meat known to impart umami taste which thus far had been overlooked in meat flavor studies. The objectives of this study were to determine the umami taste threshold of inosine 5'-monophosphate (IMP), the effects of spiking IMP on the sensory descriptive attributes of various USDA graded beef strip steaks, and to differentiate beef by IMP content using electrochemistry. USDA Prime, Choice, and Select steaks were spiked with 0.3 and 0.6 mM IMP and analyzed chemically and organoleptically. Liquid chromatography-mass spectrometry and …

Development And Characterization Of A Peanut-Shell Based Activated Carbon And The Outcomes Of A Hands-On Approach To Chemical Education, Danielle Pitre

Theses and Dissertations

Heavy metals are a recognized toxic environmental contaminant, even at very low concentrations. There have been well-known events in the last decade within the US of high amounts of lead in the drinking water supplies of cities, leading to detrimental effects within its population. Ways have been found to remove this metal, and others, from water with expensive adsorbents. The aim of the first part of this research was to create an inexpensive adsorbent from a waste material and modify it in such a way that it would be adept at removing heavy metals from water.

In Chapter I, we …

Assessing The Flood Tolerance, Physiological Mechanism, And Nutrient Mitigation Potential Of Short Rotation Woody Crops Planted On Seasonally Flooded Marginal Land Of The Lower Mississippi Alluvial Valley, Thu Ya Kyaw

Theses and Dissertations

In 2019, the Mississippi River watershed had a record-long flooding, which was comparable with the 1927 Great Mississippi River Flood. This study leveraged this flooded condition to assess the flood tolerance of eastern cottonwood (Populus deltoides) and black willow (Salix nigra) planted as short rotation woody crops (SRWCs) on seasonally flooded marginal land of the Lower Mississippi Alluvial Valley (LMAV) in 2018. The survival/mortality prediction models developed by using hydrologic and environmental variables suggested that only high flood depth affected the survival of black willow. However, eastern cottonwood was threatened by flood depth, flood duration, and …

Determining The Effects Of Elevated Carbon Dioxide On Soil Acidification, Cation Depletion, And Soil Inorganic Carbon And Mapping Soil Carbons Using Artificial Intelligence, Jannatul Ferdush

Theses and Dissertations

Soil carbon is the largest sink and source of the global carbon cycle and is disturbed by several natural, anthropogenic, and environmental factors. The global increase of atmospheric CO₂ affects soil carbon cycling through varied biogeochemical processes. The first chapter is a compilation of current information on potential factors triggering soil acidification and weathering mechanisms under elevated CO₂ and their consequences on soil inorganic carbon (SIC) pool and quality. Soil water content and precipitation were critical factors influencing elevated CO₂ effects on the SIC pool. The second chapter examines a detailed column experiment in which six soils …