Digital Commons Network^™

Concordance In Caregiver And Child Sleep Health Metrics Among Families Experiencing Socioeconomic Disadvantage: A Pilot Study, Lauren Covington, Aditi Satti, Benjamin Brewer, Rachel Blair, Ilona Duffy, Jean-Phillipe Laurenceau, Shannon Mayberry, Angeni Cordova, Elissa Hoopes, Freda Patterson

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose: Child and caregiver sleep occurs in a family system, with socioeconomically disadvantaged families experiencing disproportionately worse sleep health than more advantaged families. The extent to which objectively measured sleep health metrics (i.e., sleep duration, midpoint, regularity, efficiency) are concordant within disadvantaged family systems, including caregiver-child dyads, is not clear. To address this gap, this study aimed to: (1) characterize sleep health metrics and (2) identify levels of sleep health concordance among caregiver-child dyads living in families experiencing socioeconomic disadvantage.

Design and methods: We enrolled 20 caregivers and 26 children in this micro-longitudinal study. Eligible primary caregivers slept in …

September 1, 2022: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the September 1, 2022, meeting of the University Senate. 28 pages

Girls In Stem! Elementary Afterschool Six-Week Curriculum, Jess Li, Samavi Rafique

Honors Program: Expanded Learning Clubs

No abstract provided.

Defending The Resurrection Of Jesus Through The Reliability Of The Credible Witnesses, Gregory K. Cherven

Masters Theses

The purpose of this thesis is to illuminate the fact that there is sufficient evidence for the resurrection of Jesus Christ through the reliability of the credible witnesses. Although physical evidence is lacking, it does not mean there is not sufficient evidence. Is it necessary to have physical evidence to secure a conviction? Criminal cases will be explored in which murder convictions were secured without the recovery of a dead body, physical evidence, or a confession. The convictions were secured based solely on witness testimony. The eye-witnesses of the resurrection of Jesus are evaluated through a modern lens and there …

Continuous Glucose Monitoring Metrics For Earlier Identification Of Pre-Diabetes: Protocol For A Systematic Review And Meta-Analysis, Sara Gottfried, Laura Pontiggia, Andrew B. Newberg, Gregory Laynor, Daniel A. Monti

Institute of Emerging Health Professions Faculty Papers

Introduction: Glycaemic variability and other metrics are not well characterised in subjects without diabetes. More comprehensive sampling as obtained with continuous glucose monitoring (CGM) may improve diagnostic accuracy of the transition from health to pre-diabetes. Our goal is to investigate the glycaemic system as it shifts from health to pre-disease in adult patients without diabetes using CGM metrics. New insights may offer therapeutic promise for reversing dysglycaemia more successfully with dietary, nutritional and lifestyle change before progression occurs to pre-diabetes and diabetes.

Methods and analysis: This systematic review will include comprehensive searches of the PubMed, Scopus, Cochrane Library and ClinicalTrials.gov …

Curriculum Subcommittee, Agenda, September 1, 2022, Utah State University

Educational Policies Committee

1. Approval of Minutes - April 7, 2022
2. Program Proposals
3. Semester Course Approval Reviews
4. Other Business
5. Adjourn: 3:00 pm

Program Proposals:

• Request from the Department of Plants, Soils and Climate in the College of Agriculture and Applied Sciences to offer a new specialization (Bioinformatics and Computational Biology) to the MS and PhD degrees of Plant Science.
• Request from the Department of Theatre Arts in the Caine College of the Arts to change the name of the Theatre Arts Theatre Education Certification Option BFA to Theatre Arts Education BFA.
• Request from the Department of Mechanical and Aerospace Engineering in the College of …

Gerald Alter, Professor Emeritus, Biochemistry And Molecular Biology, Gerald Alter, Kathy Morris

Wright State University Retirees Association Oral History Project

In this August 25, 2022 oral history interview conducted by Kathy Morris, Dr. Gerald Alter discusses his career in biochemistry and his contributions to the development of Wright State University’s Biomedical Sciences Ph.D. program. He reflects on interdisciplinary research, graduate education, institutional support for scholarship, and his leadership during a period of heightened oversight of the Laboratory Animal Care and Use Committee.

Exploration Of The Effectiveness Of Trauma Systems Therapy For Foster Care, Laura Marie Doran

Doctoral Dissertations and Projects

Permanency is the desired outcome when a child has been placed into a foster care placement. That permanency outcome can involve a return to their birth family, being adopted by a new family, or guardianship with a relative (Lockwood et al., 2015). Achieving the final goal requires foster parents to understand trauma, dysregulated behaviors, and parenting techniques. The foster parent’s attachment and commitment to the foster child is affected by their understanding of those three topics. Trauma training is key to accomplishing that fuller understanding (Patterson et al., 2018). Foster parents’ comprehension of the trauma effects on behaviors and the …

Exploring The K-12 School Experiences That Contribute To Resilience In Adulthood As Described By Resilient Adults With Adverse Childhood Experiences: A Phenomenology, Susannah Wyndi Bradley

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study is to describe the K-12 school experiences that contributed to resilience in adulthood for individuals with adverse childhood experiences (ACEs). The theory guiding this study is Abraham Maslow’s hierarchy of needs as it explains how students’ achievement and engagement in learning, as well as their barriers to the same are related to students’ unmet basic needs, the pursuit of safety, and feelings of fear and mistrust. The research questions will explore how resilient adults with ACEs describe the K-12 classroom experiences that contributed to their resilience in adulthood, the classrooms where they were …

Announcing The Minderoo – Monaco Commission On Plastics And Human Health, Philip J. Landrigan, Hervé Raps, Christos Symeonides, Thomas Chiles, Maureen Cropper, Judith Enck, Mark E. Hahn, Richard Hixson, Pushpam Kumar, Adetoun Mustapha, Yongjoon Park, Margaret Spring, John Stegeman, Richard Thompson, Zhanyun Wang, Megan Wolff, Aroub Yousuf, Sarah Dunlop

School of Biological and Marine Sciences

Plastic is the signature material of our age. In the 75 years since large-scale production began in the aftermath of World War II, plastic has transformed our world, supported many of the most significant advances of modern civilization, and enabled breakthroughs in virtually every field of human endeavor. But plastic also poses great and growing dangers to human health and the environment, harms that fall disproportionately on the world’s poorest and most vulnerable populations. The extent and magnitude of these dangers are only beginning to be understood.

Fundamentals Of Arterial Blood Gas Interpretation, Jerry Yee, Stan Frinak, Naushaba Mohiuddin, Junior Uduman

Nephrology Articles

Acid-base disturbances in patients with cardiopulmonary or other disorders are common and are often misinterpreted or interpreted incompletely. Treating acid-base disorders in greater detail facilitates pathophysiologic understanding and improved therapeutic planning. Understanding the ratiometric relationship between the lungs, which excrete volatile acid as carbon dioxide, and the kidneys, which contribute to maintenance of plasma bicarbonate, allows precise identification of the dominant acid-base disturbance when more than a simple disorder is present and aids in executing a measured treatment response. Concordantly, mapping paired values of the partial pressure of carbon dioxide (PCO2) and the bicarbonate concentration ([HCO3^–]) on a …

United Nations - Convention On Biological Diversity And Cop15, Adeline Lerambert

WellBeing News

With wildlife and biodiversity in an unprecedented crisis, pressure weighs heavily on the UN‘s Convention on Biological Diversity (CBD), a multilateral environmental treaty that went into effect in 1993.

In December 2022, the CBD’s fifteenth Conference of Parties (COP15) will convene in Montreal to adopt an updated post-2020 Global BiodiversityFramework (GBF). This Framework replaces the 2011-2020 strategic plan including the Aichi five goals and twenty targets. These targets have not been met and now need to be updated.

Planning for this update on a new Global Biodiversity Framework at COP15 began in 2016. COP15 was initially scheduled to be held …

Compositionally And Density Stratified Igneous Terrain In Jezero Crater, Mars, Roger C. Wiens, Arya Udry, Olivier Beyssac, Cathy Quantin-Nataf, Nicolas Mangold, Agnès Cousin, Lucia Mandon, Tanja Bosak, Olivier Forni, Scott M. Mclennan, Violaine Sautter, Adrian Cousin, Karim Benzerara, Jeffrey R. Johnson, Lisa Mayhew, Sylvestre Maurice, Ryan B. Maurice, Ryan B. Anderson, Samuel M. Clegg, Larry Crumpler, Stanley M. Angel

Faculty Publications

Before Perseverance, Jezero crater's floor was variably hypothesized to have a lacustrine, lava, volcanic airfall, or aeolian origin. SuperCam observations in the first 286 Mars days on Mars revealed a volcanic and intrusive terrain with compositional and density stratification.The dominant lithology along the traverse is basaltic, with plagioclase enrichment in stratigraphically higher locations. Stratigraphically lower, layered rocks are richer in normative pyroxene. The lowest observed unit has the highest inferred density and is olivine-rich with coarse (1.5 millimeters) euhedral, relatively unweathered grains, suggesting a cumulate origin. This is the first martian cumulate and shows similarities to martian meteorites, which also …

Range-Wide Sources Of Variation In Reproductive Rates Of Northern Spotted Owls, Jeremy T. Rockweit, Julianna M. Jenkins, James E. Hines, James D. Nichols, Katie M. Dugger, Alan B. Franklin, Peter C. Carlson, William L. Kendall, Damon B. Lesmeister, Christopher Mccafferty, Steven H. Ackers, L. Steven Andrews, Larissa L. Bailey, Jesse Burgher, Kenneth P. Burnham, Tara Chestnut, Mary M. Conner, Raymond J. Davis, Krista E. Dilione, Eric D. Forsman, Elizabeth M. Glenn, Scott A. Gremel, Keith A. Hamm, Dale R. Herter, J. Mark Higley, Rob B. Horn, David W. Lamphear, Trent L. Mcdonald, Janice A. Reid, Carl J. Schwarz, David C. Simon, Stan G. Sovern, James K. Swingle, J. David Wiens, Heather Wise, Charles B. Yackulic

Wildland Resources Faculty Publications

We conducted a range-wide investigation of the dynamics of site-level reproductive rate of northern spotted owls using survey data from 11 study areas across the subspecies geographic range collected during 1993–2018. Our analytical approach accounted for imperfect detection of owl pairs and misclassification of successful reproduction (i.e., at least one young fledged) and contributed further insights into northern spotted owl population ecology and dynamics. Both nondetection and state misclassification were important, especially because factors affecting these sources of error also affected focal ecological parameters. Annual probabilities of site occupancy were greatest at sites with successful reproduction in the previous year …

Comparing Kidney Health Outcomes In Children, Adolescents, And Adults With Focal Segmental Glomerulosclerosis., Debbie S. Gipson, Jonathan P. Troost, Cathie Spino, Samara Attalla, Joshua Tarnoff, Susan Massengill, Richard Lafayette, Virginia Vega-Warner, Sharon Adler, Patrick Gipson, Matthew Elliott, Frederick Kaskel, Damian Fermin, Marva Moxey-Mims, Richard N. Fine, Elizabeth J. Brown, Kimberly Reidy, Katherine Tuttle, Keisha Gibson, Kevin V. Lemley, Larry A. Greenbaum, Meredith A. Atkinson, Sangeeta Hingorani, Tarak Srivastava, Christine B. Sethna, Kevin Meyers, Cheryl Tran, Katherine M. Dell, Chia-Shi Wang, Jennifer Lai Yee, Matthew G. Sampson, Rasheed Gbadegesin, J J Lin, Tammy Brady, Michelle Rheault, Howard Trachtman

Manuscripts, Articles, Book Chapters and Other Papers

Importance: Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease (ESKD) across the lifespan. While 10% to 15% of children and 3% of adults who develop ESKD have FSGS, it remains uncertain whether the natural history differs in pediatric vs adult patients, and this uncertainty contributes to the exclusion of children and adolescents in clinical trials.

Objective: To examine whether there are differences in the kidney health outcomes among children, adolescents, and adults with FSGS.

Design, Setting, and Participants: This cohort study used pooled and parallel analyses, completed July 5, 2022, from 3 complimentary data sources: (1) …

Editorial: Progress In Understanding The Immunogenetic Basis Of Disease Susceptibility And Outcomes, Tina Bharani, Divyansh Agarwal

Department of Surgery Faculty Papers

No abstract provided.

Controlling Multiple Covid-19 Epidemic Waves: An Insight From A Multi-Scale Model Linking The Behaviour Change Dynamics To The Disease Transmission Dynamics, Biao Tang, Weike Zhou, Xia Wang, Hulin Wu, Yanni Xiao

Faculty, Staff and Student Publications

COVID-19 epidemics exhibited multiple waves regionally and globally since 2020. It is important to understand the insight and underlying mechanisms of the multiple waves of COVID-19 epidemics in order to design more efficient non-pharmaceutical interventions (NPIs) and vaccination strategies to prevent future waves. We propose a multi-scale model by linking the behaviour change dynamics to the disease transmission dynamics to investigate the effect of behaviour dynamics on COVID-19 epidemics using game theory. The proposed multi-scale models are calibrated and key parameters related to disease transmission dynamics and behavioural dynamics with/without vaccination are estimated based on COVID-19 epidemic data (daily reported …

The Pro-Fibrotic Response To Lens Injury Is Signaled In A Pi3k Isoform-Specific Manner, A. Sue Menko, Janice L. Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The signaling inputs that function to integrate biochemical and mechanical cues from the extracellular environment to alter the wound-repair outcome to a fibrotic response remain poorly understood. Here, using a clinically relevant post-cataract surgery wound healing/fibrosis model, we investigated the role of Phosphoinositide-3-kinase (PI3K) class I isoforms as potential signaling integrators to promote the proliferation, emergence and persistence of collagen I-producing alpha smooth muscle actin (αSMA+) myofibroblasts that cause organ fibrosis. Using PI3K isoform specific small molecule inhibitors, our studies revealed a requisite role for PI3K p110α in signaling the CD44+ mesenchymal leader cell population that we previously identified as …

Using Direct Pcr For Disaster Victim Identification Reference Samples, Mary Habib

Student Theses

Forensic genetic testing is an important tool for the identification of victims after a mass fatality event but degradation of remains, presence of PCR inhibitors, and limited amounts of sample can make testing difficult. Standard protocols typically include extraction of genetic material from recovered post-mortem samples, and from ante-mortem reference samples or families of a missing person. This is a time-consuming and laborious process and may result in the loss of trace amounts of DNA available for amplification. Incorporating workflows that bypass the extraction step and directly amplify recovered DNA for short tandem repeat (STR) profile generation has the potential …

Linking Trauma To The Prevalence Of Civil War, Erik W. Goepner

The US Army War College Quarterly: Parameters

No abstract provided.

Arabidopsis Shoot Gravitropism Requires The Mediator Coactivator Complex, Gabriella Newton

Honors Theses

Gravitropism is a plant response to gravity in directing the growth of its organs, such as the root and the stem. Gravity is sensed by statocytes, unique cells that contain starch-filled amyloplasts, which trigger gravitropic growth response by modulating the distribution of growth hormone auxin in the elongation zone of the stem and root. Despite the fact that multiple factors have been identified as key regulators of shoot negative gravitropism, how these factors are regulated at the transcriptional level is largely unknown. In this study, we explore the role of transcriptional machinery in regulating shoot gravity sensing and responses by …

G Protein-Coupled Receptor Kinase 6 (Grk6) Regulates Insulin Processing And Secretion Via Effects On Proinsulin Conversion To Insulin, Matthew J Varney, Wouter Steyaert, Paul J Coucke, Joris R Delanghe, David E Uehling, Babu Joseph, Richard Marcellus, Rima Al-Awar, Jeffrey L Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

Recent studies identified a missense mutation in the gene coding for G protein-coupled receptor kinase 6 (GRK6) that segregates with type 2 diabetes (T2D). To better understand how GRK6 might be involved in T2D, we used pharmacological inhibition and genetic knockdown in the mouse β-cell line, MIN6, to determine whether GRK6 regulates insulin dynamics. We show inhibition of GRK5 and GRK6 increased insulin secretion but reduced insulin processing while GRK6 knockdown revealed these same processing defects with reduced levels of cellular insulin. GRK6 knockdown cells also had attenuated insulin secretion but enhanced proinsulin secretion consistent with decreased processing. In support …

Multi-Omics Analysis Reveals Metabolic And Epigenetic Changes Associated With Macrophage Polarization, Mark L. Sowers, Hui Tang, Vipul K. Singh, Arshad Khan, Abhishek Mishra, Blanca I. Restrepo, Chinnaswamy Jagannath, Kangling Zhang

School of Medicine Publications

Macrophages (MФ) are an essential immune cell for defense and repair that travel to different tissues and adapt based on local stimuli. A critical factor that may govern their polarization is the cross-talk between metabolism and epigenetics. However, simultaneous measurements of metabolites, epigenetics, and proteins (phenotype) has been a major technical challenge. To address this, we have developed a novel triomics approach using mass spectrometry to comprehensively analyze metabolites, proteins, and histone modifications, in a single sample. To demonstrate this technique, we investigated the metabolic-epigenetic-phenotype axis following polarization of human blood-derived monocytes into either 'pro-inflammatory M1'- or 'anti-inflammatory M2-' MФs. …

Short-Finned Pilot Whales Exhibit Behavioral Plasticity In Foraging Strategies Mediated By Their Environment, Jeanne M. Shearer, Frants H. Jensen, Nicola J. Quick, Ari Friedlaender, Brandon Southall, Douglas P. Nowacek, Matthew Bowers, Heather J. Foley, Zachary T. Swaim, Danielle M. Waples, Andrew J. Read

School of Biological and Marine Sciences

Predators adapt their foraging behavior to exploit a variety of prey in a range of environments. Short-finned pilot whales are wide-ranging predators in tropical and sub-tropical oceans, but most previous studies of their foraging ecology have been conducted near oceanic islands. We deployed sound- and movement-recording tags on 43 short-finned pilot whales off Cape Hatteras, North Carolina, USA, to measure their foraging behavior in a continental shelf-break ecosystem and investigate how variation in the environment shapes their behavior. Overall, the foraging behavior of pilot whales off Cape Hatteras was similar to that of their counterparts from island-associated habitats. Off Cape …

Adenoid Ameloblastoma With Dentinoid, Sanpreet S. Sachdev, Tabita J. Chettiankandy, Manisha A. Sardar, Yogita Adhane, Aakruti M. Shah, Alphonsa E. Grace

Sultan Qaboos University Medical Journal

Ameloblastoma and adenomatoid odontogenic tumors are the most common odontogenic neoplasms. However, hybrid variant of the two lesions, Adenoid Ameloblastoma with dentinoid is extremely rare. The lesion comprises of characteristic histopathological features of Ameloblastoma and Adenomatoid odontogenic tumor and also shares certain clinical characteristics with either of the entities. Adenoid Ameloblastoma with dentinoid may be considered at the more aggressive end of spectrum of benign odontogenic neoplasms. Owing to the frequent tendency of lesion to be underdiagnosed, careful histopathological screening of submitted biopsies is warranted. With the increase in number of reported cases in the recent years, it is likely …

Evaluation Of Ruxolitinib Versus Best Available Therapy In Treating Primary Myelofibrosis, Kawa M. Hasan, Ahmed Y. Elmeshhadany, Nazar P. Shabila

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate the effectiveness of ruxolitinib and compare it with the best available therapy in patients with primary myelofibrosis. Ruxolitinib is a Janus kinase inhibitor that is approved for the treatment of myelofibrosis. The therapeutic protocol has changed after the introduction of ruxolitinib. Methods: In this retrospective study, 72 patients with primary myelofibrosis were scrutinised from January 2012 to January 2018 at Nanakali Hemato-Oncology Teaching Centre in Erbil, Iraqi Kurdistan. The patients were divided into two cohorts: 26 of them were treated with ruxolitinib and 46 received the best available therapy. The patients’ characteristics, their response …

Spinal Cord Dose Reduction Using A Jaw-Blocking Vmat Technique - A Retrospective Study Of Chordoma And Chondrosarcoma Patients, Amber Wyatt

Masters Projects

Chordomas and chondrosarcomas are rare tumors that commonly experience loco-regional recurrence after primary treatment, making management of these tumors complex and difficult. Published case series reporting post-surgical outcomes for chordoma indicate that loco-regional recurrence affects more than 50% of patients treated with macroscopic complete resection with or without RT. Notably, a high proportion of recurrences occur late (after 5 and 10 years), requiring long-term follow-up. Chordomas and chondrosarcomas are considered to be radioresistant and require high doses of radiation greater than 60 Gy (Catanzano et al., 2019). There is a little data available regarding the most effective way to minimize …

Klf5 Governs Sphingolipid Metabolism And Barrier Function Of The Skin, Ying Lyu, Yinglu Guan, Lisa Deliu, Ericka Humphrey, Joanna K Frontera, Youn Joo Yang, Daniel Zamler, Kun Hee Kim, Vakul Mohanty, Kevin Jin, Vakul Mohanty, Virginia Liu, Jinzhuang Dou, Lucas J Veillon, Shwetha V Kumar, Philip L Lorenzi, Yang Chen, Kathleen M Mcandrews, Sergei Grivennikov, Xingzhi Song, Jianhua Zhang, Yuanxin Xi, Jing Wang, Ken Chen, Priyadharsini Nagarajan, Yejing Ge

Faculty, Staff and Student Publications

Stem cells are fundamental units of tissue remodeling whose functions are dictated by lineage-specific transcription factors. Home to epidermal stem cells and their upward-stratifying progenies, skin relies on its secretory functions to form the outermost protective barrier, of which a transcriptional orchestrator has been elusive. KLF5 is a Krüppel-like transcription factor broadly involved in development and regeneration whose lineage specificity, if any, remains unclear. Here we report KLF5 specifically marks the epidermis, and its deletion leads to skin barrier dysfunction in vivo. Lipid envelopes and secretory lamellar bodies are defective in KLF5-deficient skin, accompanied by preferential loss of complex sphingolipids. …

The Diagnostic Dilemma Of Ruptured Liver Metastasis In A Patient With Lung Cancer, K S. Jayanth, Shivakumar Madan, Balakrishnan Gurushankari, Sathasivam Sureshkumar, Amaranathan Anandhi, Rajesh N. G, Vikram Kate

Sultan Qaboos University Medical Journal

Spontaneous rupture of a metastatic liver tumour is rarely documented in the literature when compared to hepatocellular carcinoma and other liver lesions, especially from a lung primary. We report a case of ruptured liver metastasis from an adenocarcinoma of the lung mimicking ruptured liver abscess, challenging the clinical diagnosis. A 42-year-female patient presented to a tertiary care institute in 2020 with complaints of abdominal pain, breathlessness and fever. On examination, the patient was tachypnoeic with a right hypochondriac mass. A contrast-enhanced computed tomography of abdomen and thorax revealed an ill-defined heterogeneously enhancing lesion in the liver with a communicating subcapsular …

Health Related Challenges Of Rural Elderly Living In Co-Residential Family Care Arrangements, Kidus Yenealem Mefteh

The Qualitative Report

Family plays an indispensable role in the care and support of the rising number of older people particularly in developing countries like Ethiopia where the system of public transfer is minimal. Previous studies in Ethiopia focus on institutionalized and urban-dwelling elderly with little attention to the elderly in the informal care paradigm and rural areas. This study aims to explore the health-related experiences of dependent rural elderly who get care and support within a family setting. A phenomenology method was used, and in-depth interviews were employed to collect data from purposively sampled elders. Data were inductively coded and developed into …