Digital Commons Network^™

Extracellular Vesicle-Associated Biomolecules As Potential Biomarkers For Alzheimer's Disease Diagnosis, Lina Bedoya Martinez

Electronic Theses and Dissertations, 2020-2023

Alzheimer's disease (AD) involves progressive neurodegeneration leading to the loss of normal neuronal function. Extracellular accumulation of amyloid-beta (Aß), through the abnormal cleavage of the amyloid precursor protein (APP) by ß- and γ-secretases, is one of the hallmarks of AD. Current research focuses on finding potential candidates for biomarkers and techniques with improved sensitivity for early disease detection. Extracellular vesicles (EVs) found in body fluids are a source of biomarkers for AD diagnosis. EVs transport pathologically significant biomolecules, like nucleic acids and proteins, across the blood-brain barrier, mediating local and distant cell-to-cell communication. Therefore, this study evaluated EV-associated DNA and …

Étude Visant À Mieux Guider L’Évaluation Des Risques Des Travailleurs Exposés Aux Nanoparticules (Np) : Existe-T-Il Différentes Propriétés Inflammatoires Des Np Liées Au Sexe?, Marion Vanharen, Abdelaziz Saafane, Alexanne Léveillé, Thomas Mahbeer, Denis Girard

Rapports de recherche scientifique

Les nanotechnologies offrent un important potentiel d’exploitation dans des secteurs industriels variés, pour lequel les bénéfices financiers ne sont pas négligeables. À l’instar des provinces canadiennes et de nombreux pays industrialisés, le Québec voit un nombre grandissant de compagnies produisant des nanomatériaux et des nanoparticules (NP) se développer, sans oublier celles qui introduisent de plus en plus de NP dans leurs produits. Le nombre de travailleurs québécois œuvrant dans la fabrication et dans la synthèse des NP augmentera dans les années à venir. De plus, le nombre de travailleurs appelés à manipuler et à transformer des NP dans les domaines …

Masculinity And Depression: A Qualitative Content Analysis Of The Counseling Literature’S Recommendations On Caring For Men From 2012-2021, Jean Taylor

Dissertations, Theses, and Projects

This study examined how the counseling literature between the years of 2012-2021 addressed the diagnosis and treatment for men with depression. Qualitative Content Analysis (QCA) was used to examine four publications of the American Counseling Association: Journal of Counseling and Development (JCD), Journal of Humanistic Counseling (JHC), Journal of Multicultural Counseling and Development (JMCD), and Counselor Education and Supervision (CES). Four research questions guided the study: 1. How many articles in the selected counseling journals focus on men and depression between 2012 and 2021, and what percentage of the total articles do they represent? 2. What specific types of studies …

The Stories We Tell: Engaging With Authority In Critical Health Pedagogy, Rosalinda Hernandez Linares-Gray, Sara Newman Carroll, Emily K. Smith

Communications in Information Literacy

This Innovative Practices piece details the design of a scaffolded project in a public health course that paired a narrative inquiry assignment with an empirical health literature review assignment to highlight both the positivist and constructivist epistemologies of critical health research in public health. The authors discuss and reflect on the five parts that constitute the project, student learning outcomes, and the benefits of engaging with critical information literacy in an undergraduate public health course. The goal of this article is to provide practical applications of critical information literacy to librarians in the health sciences who work with undergraduate students.

Making Emotions Trustworthy, Xiaoyu Ke

Arts & Sciences Graduate Student Theses and Dissertations

I investigate ways by which agents can make their emotions more trustworthy from a perspective that’s informed by recent psychological research on the nature of emotion regulation. This dissertation is a collection of three articles, each addressing one type of cases of untrustworthy emotions in a particular context. Chapter one (Developing Appropriate Emotions) concerns emotions that are untrustworthy because they are irrelevant to the moral or epistemic judgements at hand. By situating the problem in the context of a situationist challenge to neo-Aristotelian virtue ethics, I argue that we can address this problem by developing ameliorative abilities such as emotion …

A Synthesis-Based Approach To The Study Of Fe(Ii) Oxidation In Smectites, Robert Joe Kupper Ii

Arts & Sciences Graduate Student Theses and Dissertations

Smectite clay minerals are present in diverse environments on Earth as a major product of silicate weathering. Although smectites are compositionally varied, they almost always incorporate iron. Iron-bearing smectites are an important component of the biogeochemical iron cycle, serving as a major iron fraction in many soils and altered rocks as well as participating in redox reactions within the surrounding environment. Iron incorporates into smectites in the ferric [Fe(III)] form at the modern, oxygenated surface of Earth but clays forming in anoxic settings instead incorporate ferrous iron [Fe(II)]. Owing to their ubiquity at the surface of the modern Earth, the …

Dealing With Dimensionality: Problems And Techniques In High-Dimensional Statistics, Cezareo Rodriguez

Arts & Sciences Graduate Student Theses and Dissertations

In modern data analysis, problems involving high dimensional data with more variables than subjects is increasingly common. Two such cases are mediation analysis and distributed optimization. In Chapter 2 we start with an overview of high dimensional statistics and mediation analysis. In Chapter 3 we motivate and prove properties for a new marginal screening procedure for performing high dimensional mediation analysis. This screening procedure is shown via simulation to perform better than benchmark approaches and is applied to a DNA methylation study. In Chapter 4 we construct a cryptosystem that accurately performs distributed penalized quantile regression in the high-dimensional setting …

Recommendations For Sustainable Tourism In Patagonia: An Exploratory Analysis Of Sustainable Tourism In Costa Rica, The Nordic Region, And Thailand’S Communities, Julia K. Lowery

Undergraduate Honors Theses

This thesis explores different levels of governance and its role towards actualizing sustainable tourism in Patagonia. With the growing threat of climate change, international destinations such as Patagonia are looking to continue building their tourism industries in a sustainable way. Through analyzing case studies of national governance in Costa Rica, multi-national governance in the Nordic region, and community-based tourism in Thailand, we can better understand how each form of governance has the potential to create a sustainable tourism industry. With this understanding of successful governance in my case studies, as well as understanding the historical and political forces that have …

Of Bugs And Wildfires: Tracing The Impacts Of Changing Wildfire Regimes On Aquatic Bacteria And Macroinvertebrates Using Edna, Isabella M. Errigo

Theses and Dissertations

Human disruption of climate, habitat, and ignition has altered the behavior of wildland fire at local to continental scales. In many regions, novel fire regimes are emerging that threaten to exceed the capacity for local management to protect human wellbeing and ecosystem function. Simultaneous changes in climate, species composition, and fire management have resulted in extreme fire behavior in many regions. For the Western United States, the emerging novel fire regime consists of more frequent, severe, and intense wildfires, with annual area burned by wildfire having doubled and high-severity wildfire area having increased 8-fold since the 1980s. The impacts of …

Laywoman Of Right Faith: The Religious Writings Of Wang Peihua (1767-1792), Meijie Shen

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATIONLaywoman of Right Faith: The Religious Writings of Wang Peihua (1767-1792) by Meijie Shen Doctor of Philosophy in Chinese Language and Literature Washington University in St. Louis, 2022 Professor Beata Grant, ChairThis dissertation is a case study of an eighteenth-century Buddhist laywoman named Wang Peihua (1767-1792) from the affluent Jiangnan area of imperial China. This period saw the flourishing of women’s education and writings, thanks to which we have collections left behind by them that document their own lives and in their own voice, which enabled us to explore their religious experience. As women started to enter …

Nanoparticle Conjugated Photosensitizer For Targeted Photodynamic Inactivation Of Cancer Cells, Symone D. Crowder

Honors College Theses

Photodynamic therapy (PDT) is considered to be a potential replacement for traditional methods of chemotherapy. It includes the administration of photosensitizing agents (PS), which generate reactive oxygen species (ROS) upon excitation at a specific wavelength. With new outlooks and techniques, cancer research is advancing each day. It has allowed the progress of several theranostic drug delivery systems (DDS) exploring the area of nanomedicine.2 In the present work, a Rhodamine derivative, Rhodamine 6G (R6G) was used as the PS. In general, rhodamine compounds undergo cytotoxic reactions on photoexcitation by electron transfer reactions with folic acid within cells, making them a favorable …

Data Dimensionality Reduction Techniques: What Works With Machine Learning Models, Yuting Chen

Electronic Theses and Dissertations, 2020-2023

High-dimensional data has a wide range of applications in research, such as education, health, social media, and many other research fields. However, the high dimensionality of data can raise many problems for data analyses. This study focuses on commonly used techniques of dimensionality reduction for machine learning models, which play an essential and inevitable role in data prepossessing and statistical analysis. The main issues of high-dimensional data for machine learning tasks include the accuracy of data classification and visualization in machine learning models. Therefore, in this study, machine learning algorithms are used to predict and classify datasets to evaluate the …

Structure And Morphology Of Photoreactive Monomer–Nanoparticle Mixtures Under Patterned Irradiation, Shreyas Pathreeker

Dissertations - ALL

Establishing processing–structure relationships is central to materials science. In this work, we seek answers to whether morphology can be controlled during Light–Induced Self–Writing (LISW) in polymer composite materials, and if yes, how? LISW is based on the ability of light to undergo divergence–free propagation in photoreactive media due to photopolymerization–induced rise in refractive index of the medium. Notably, LISW in polymeric materials has found use predominantly for the fabrication of optical waveguides but has not been explored in polymer–inorganic mixtures. Using through–mask projection which creates a spatially periodic array of optical beams, this work extends LISW to nanoparticle–monomer mixtures to …

Review Of Nutrition: Science And Everyday Application- Second Edition, Jorge L. Canchola

Open Educational Resources - Reviews

No abstract provided.

National Security Concept Of Mongolia, Mongolian Ministry Of Foreign Affairs

Documents

No abstract provided.

Mommy Issues: Louisiana’S Gap In Parental Rights For Unmarried, Same-Sex Couples, Lily Pavy

Louisiana Law Review

No abstract provided.

Uneggspected: Louisiana’S Scrambled Approach To Ownership Of Frozen Embryos After Dissolution Of Marriage, A. Brooke Reedy

Louisiana Law Review

No abstract provided.

Health Management And Adaptive Control Of Distributed Spacecraft Systems, Tatiana Alejandra Gutierrez Martinez

Doctoral Dissertations and Master's Theses

As the development of challenging missions like on-orbit construction and collaborative inspection that involve multi-spacecraft systems increases, the requirements needed to improve post-failure safety to maintain the mission performance also increases, especially when operating under uncertain conditions. In particular, space missions that involve Distributed Spacecraft Systems (e.g, inspection, repairing, assembling, or deployment of space assets) are susceptible to failures and threats that are detrimental to the overall mission performance. This research applies a distributed Health Management System that uses a bio-inspired mechanism based on the Artificial Immune System coupled with a Support Vector Machine to obtain an optimized health monitoring …

On-Board Artificial Intelligence For Failure Detection And Safe Trajectory Generation, Eduardo Morillo

Doctoral Dissertations and Master's Theses

The use of autonomous flight vehicles has recently increased due to their versatility and capability of carrying out different type of missions in a wide range of flight conditions. Adequate commanded trajectory generation and modification, as well as high-performance trajectory tracking control laws have been an essential focus of researchers given that integration into the National Air Space (NAS) is becoming a primary need. However, the operational safety of these systems can be easily affected if abnormal flight conditions are present, thereby compromising the nominal bounds of design of the system's flight envelop and trajectory following. This thesis focuses on …

Weaving Subjects At The Obraje De Chincheros: Indigenous Contributions To The Colonial Aesthetic, Maria Smith

Dissertations - ALL

This dissertation highlights the contributions that colonial textile producers at the colonial textile mill, the Obraje de Chincheros (c. 1570-1820), influenced the colonial Peruvian aesthetic. Peruvian weavers were seen as superior weavers at the time of the Spanish invasion and obrajes were established to salvage this skill while they were simultaneously subjected to colonial control strategies. At the Obraje, rural indigenous and mestizo textile producers were disciplined into the colonial hierarchy via their labor and conversion to Catholicism. At the same time, the Obraje workforce, largely women and children, shaped the colonial aesthetic via their labor. It was their laborial …

Pnp Maxtools: Autonomous Parameter Control In Maxmsp Utilizing Mir Algorithms, Austin Alexander Franklin

LSU Doctoral Dissertations

This research presents a new approach to computer automation through the implementation of novel real-time music information retrieval algorithms developed for this project. It documents the development of the PnP.Maxtools package, a set of open source objects designed within the popular programming environment MaxMSP. The package is a set of pre/post processing filters, objective and subjective timbral descriptors, audio effects, and other objects that are designed to be used together to compose music or improvise without the use of external controllers or hardware. The PnP.Maxtools package objects are designed to be used quickly and easily using a `plug and play' …

Integration Of In Vitro And In Vivo Models To Predict Cellular And Tissue Dosimetry Of Nanomaterials Using Physiologically Based Pharmacokinetic Modeling, Zhoumeng Lin, Santosh Aryal, Yi-Hsien Cheng, Andre J. Gesquierre

Pharmacy Faculty Publications and Presentations

Nanomaterials (NMs) have been increasingly used in a number of areas, including consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation of safety, efficacy, and potential toxicity of NMs. Current evaluation of NM efficacy and safety involves the time-consuming collection of pharmacokinetic and toxicity data in animals and is usually completed one material at a time. This traditional approach no longer meets the demand of the explosive growth of NM-based products. There is an emerging need to develop methods that can help design safe and effective NMs in an efficient manner. In this review article, we critically …

Karafsin, A Unique Mono-Acylated Flavonoid Apiofurnoside From The Leaves Of Apium Graveolens Var. Secalinum Alef: In Vitro And In Vivo Anti-Inflammatory Assessment, Noha Swilam, Mahmoud Nawwar, Eman Mostafa, Dalia Mostafa, Mai Ragab

Pharmacy

Celery ethanol extract (CEE) of leaves of Apium graveolens var. secalinum Alef, showed high phenolic content with significant antioxidant activity using DPPH and ORAC assay. Two unique unknown compounds, apigenin 7-O-mono-apiofuranoside and acylated flavonoid, 7-O- (5″-E-p-coumaroyl)-apiofuranside (karafsin) were identified in CEE for the first time by a full structural analysis, along with 6 known compounds. While karafsin significantly inhibited cyclooxygenase-2 by 42.52 ± 2.88 and 70.33 ± 2.97 % at 50 and 100 mg/mL and 5-lipoxygenase by 37.33 ± 2.87 and 75.77 ± 2.57 % at 50 and 100 mg/mL in raw macrophage cells challenged with Escherichia coli lipopolysaccharide, CEE …

Winter Commencement: December 15-16, 2022, University Of North Dakota

UND Commencement Programs

UND Winter Commencement program from December 15 and 16, 2022.

Evaluation Of Blood-Based, Extracellular Vesicles As Biomarkers For Aging-Related Tdp-43 Pathology, Charisse N. Winston, Sonal Sukreet, Haley Lynch, Virginia M. -Y. Lee, Donna M. Wilcock, Peter T. Nelson, Robert A. Rissman

Neurology Faculty Publications

Introduction: Limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE-NC) is a recently characterized brain disease that mimics Alzheimer’s disease (AD) clinically. To date, LATE-NC is difficult to diagnose antemortem using clinical information or biomarkers. Recent studies suggest concentrations of extracellular vesicle (EVs) protein cargo derived from neuronal and glial cells may serve as useful diagnostic biomarkers for AD and other neurodegenerative diseases.

Methods: TDP-43 was evaluated in neuronal (NDEVs), astrocyte (ADEVs), and microglial derived extracellular vesicles (MDEVs). EV preparations were isolated from the plasma of research subjects with autopsy-confirmed diagnoses, including many with LATE (n = 22). …

Effects Of Forest Structure And Human Influence On The Call Rate Of Owls In The Piedmont Forest Of Northwestern Argentina, Maila Scheffer, N. Politi, S. Martinuzzi, L. Rivera

Neotropical Biodiversity

No abstract provided.

System Shock: Using -Omics Data To Characterize Biological Remodeling In The Microbiome, Resistome, And Transcriptome Of Bacteria, Winston Eugene Anthony

Arts & Sciences Graduate Student Theses and Dissertations

The human experience is indelibly linked to microbial life. So much so, that the holobiont theory has been coined to define the assemblage of host and microbe as a discrete ecological unit. Perturbation of the commensal microbiome can create niche space for pathogens, which through the concomitant rise of antimicrobial resistance represent an ever-evolving danger. In Chapter 2 of this dissertation, I describe the results of an interventional study designed to directly perturb the healthy gut microbiome and observe the dynamics of taxonomic composition and functional recovery. I observe significant decreases after 5 days of antibiotic treatment in the gold …

An Online Vignette Study To Examine The Outcomes Of A Preclinical Alzheimer Disease Diagnosis, Matthew John Wynn

Arts & Sciences Graduate Student Theses and Dissertations

As Alzheimer disease research forges ahead, and new potential treatments are developed, a conceptualization is emerging of a presymptomatic disease stage. This stage, known as preclinical Alzheimer disease, is characterized by the buildup of amyloid beta and tau proteins in the brain to abnormal levels in a cognitively normal person. There are unknown potential risks and benefits of communicating biological marker risk information for Alzheimer disease using the preclinical Alzheimer disease diagnostic label. The current study uses a vignette methodology to measure older adults’ understanding of risk information when presented with information regarding their risk for developing Alzheimer dementia. Participants …

Insights Into The Non-Osmoregulatory Function Of A Pollen-Specific Mechanosensitive Ion Channel, Kari Miller

Arts & Sciences Graduate Student Theses and Dissertations

Pollen, the male gametophyte of flowering plants, delivers the sperm cells to the ovule to carry out sexual reproduction. During this process, the pollen grain undergoes dramatic physical changes. Survival requires careful control of cell mechanics, particularly the balance between protoplast expansion and cell wall resistance. One control mechanism is the use of a mechanosensitive (MS) ion channel, MscS-Like (MSL)8. This pollen-specific protein was previously shown to be essential for pollen survival during hydration and was proposed to function as a tension-gated osmoregulator. However, direct proof of osmoregulation during initial hydration has not yet been found. In fact, studies of …

Emerging Insights Into A Role For Topoisomerase Iib And Methyl-Cpg Binding Protein 2 In Regulating Neuronal Transcription, Sabin Nettles

Arts & Sciences Graduate Student Theses and Dissertations

The mammalian brain has unparalleled diversity of cell types with distinct molecular, morphological, connectional and functional properties. The specialization of these cells occurs during development through a series of spatially and temporally controlled changes in gene expression that are critical for proper assembly and function. Neurons in particular have complex and elaborate gene regulatory systems which allow specific combinations of genes to be expressed at distinct levels and at discrete developmental stages, giving rise to heterogenous neuronal subtypes. Identifying unique neuronal gene regulatory factors that contribute to the dynamic changes in gene expression are critical to understanding the molecular mechanism …