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The Rider (2022-09-26), Verilu Infante

The Rider Archives

Vol.8 No.5

Short Warm-Side Wet-Bulb Temperature Distribution Tails Lead To Accelerated Increases In Extreme Threshold Exceedances Under Global Warming, Yianna Sotirios Bekris

Dissertations and Theses

Humid-heat extremes threaten human health and are increasing in frequency with global warming, so elucidating factors affecting their rate of change is critical. This thesis examines the role of historical (1985-2014) wet-bulb temperature distribution tail shape on the probability of wet-bulb temperature extreme threshold exceedances under 2°Celsius global warming. Analysis of global climate models and reanalysis reveals that non-Gaussian wet-bulb temperature distribution tails are common worldwide across extensive, spatially coherent regions. More rapid increases in the number of days exceeding the historical 95th percentile are projected in locations with shorter-than-Gaussian warm-side tails. Of the two primary components of wet-bulb temperature, …

The Congruence Of Parent-Teacher Relationships For Students With Autism: The Role Of Teacher Efficacy And School Climate, Morgan Johnson

Theses and Dissertations

Ecological Systems Theory (Bronfenbrenner, 1979) can be used as a framework to examine the importance of communication and collaboration among parents and teachers as both are important stakeholders in the field of education. Parent-teacher relationships are critical for autistic students particularly due to individualized education plans and the provision of special education services (IDEA, 2004). The current study examined relationships between parent-teacher dyads in terms of congruence, the degree to which both parties are in agreement about their relationship. This study was unique in its mixed methods design, combining quantitative and qualitative data, as well as its use of dyadic …

Capsaicin Inhibits Multiple Voltage-Gated Ion Channels In Rabbit Ventricular Cardiomyocytes In Trpv1-Independent Manner, Dmytro Isaev, Keun-Hang Susan Yang, Waheed Shabbir, Frank Christopher Howarth, Murat Oz

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Capsaicin is a naturally occurring alkaloid derived from chili pepper which is responsible for its hot, pungent taste. It exerts multiple pharmacological actions, including pain-relieving, anti-cancer, anti-inflammatory, anti-obesity, and antioxidant effects. Previous studies have shown that capsaicin significantly affects the contractility and automaticity of the heart and alters cardiovascular functions. In this study, the effects of capsaicin were investigated on voltage-gated ion currents in rabbit ventricular myocytes. Capsaicin inhibited rapidly activated (I_Kr) and slowly activated (I_Ks) K⁺ currents and transient outward (I_to) K⁺ current with IC₅₀ values of 3.4 µM,14.7 µM, …

September 26, 2022

The Gavel Gazette

No abstract provided.

Assessing The Compliance Of Dental Clinicians Towards Regulatory Infection Control Guidelines Using A Newly Developed Survey Tool: A Pilot Cross-Sectional Study In India, Pragati Kaurani, Kavita Batra, Himangini Rathore Hooja, N. Gopi Chander, Anamitra Bhowmick, Suraj Arora, Suheel Manzoor Baba, Shafait Ullah Khateeb, Anshad M. Abdulla, Vishakha Grover, Priyanka Saluja

School of Medicine Faculty Research

Adherence to the dental practice regulatory guidelines instituted during the COVID- 19 pandemic is essential to minimize the transmission of SARS-CoV-2 strains. Given the lack of a valid and reliable survey tool to assess the adherence to dental practice guidelines, this study aims to develop, validate, and test a survey tool on a pilot sample of dental clinicians practicing in India. A survey tool was developed/validated through a sequential phasic approach: Phase Ideveloping survey using conceptual and literature framework; Phase II: ascertaining its validity and reliability; Phase III: pilot testing; and Phase IV: assessing construct validity by exploratory factor analysis …

Loss Of Num1-Mediated Cortical Dynein Anchoring Negatively Impacts Respiratory Growth, Antoineen J. White, Clare S. Harper, Erica M. Rosario, Jonathan V. Dietz, Hannah G. Addis, Jennifer L. Fox, Oleh Khalimonchuk, Laura L. Lackner

Department of Biochemistry: Faculty Publications

Num1 is a multifunctional protein that both tethers mitochondria to the plasma membrane and anchors dynein to the cell cortex during nuclear inheritance. Previous work has examined the impact loss of Num1-based mitochondrial tethering has on dynein function in Saccharomyces cerevisiae; here, we elucidate its impact on mitochondrial function. We find that like mitochondria, Num1 is regulated by changes in metabolic state, with the protein levels and cortical distribution of Num1 differing between fermentative and respiratory growth conditions. In cells lacking Num1, we observe a reproducible respiratory growth defect, suggesting a role for Num1 in not only maintaining mitochondrial …

Interaction Networks Are Driven By Community-Responsive Phenotypes In A Chitin-Degrading Consortium Of Soil Microbes, Ryan Mcclure, Yuliya Farris, Robert Danczak, William Nelson, Hyun-Seob Song, Aimee Kessell, Sneha Couvillion, Christopher Henry, Janet K. Jansson, Kristen S. Hofmockel

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Soil microorganisms provide key ecological functions that often rely on metabolic interactions between individual populations of the soil microbiome. To better understand these interactions and community processes, we used chitin, a major carbon and nitrogen source in soil, as a test substrate to investigate microbial interactions during its decomposition. Chitin was applied to a model soil consortium that we developed, “model soil consortium-2” (MSC-2), consisting of eight members of diverse phyla and including both chitin degraders and nondegraders. A multiomics approach revealed how MSC-2 community-level processes during chitin decomposition differ from monocultures of the constituent species. Emergent properties of both …

Interaction Networks Are Driven By Community-Responsive Phenotypes In A Chitin-Degrading Consortium Of Soil Microbes, Ryan Mcclure, Yuuliya Farris, Robert Danczak, William Nelson, Hyun-Seob Song, Aimee Kessell, Joon-Yong Lee, Sneha Couvillion, Christopher Henry, Janet K. Jansson, Kristen S. Hofmockel

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Soil microorganisms provide key ecological functions that often rely on metabolic interactions between individual populations of the soil microbiome. To better understand these interactions and community processes, we used chitin, a major carbon and nitrogen source in soil, as a test substrate to investigate microbial interactions during its decomposition. Chitin was applied to a model soil consortium that we developed, “model soil consortium-2” (MSC-2), consisting of eight members of diverse phyla and including both chitin degraders and nondegraders. A multiomics approach revealed how MSC-2 community-level processes during chitin decomposition differ from monocultures of the constituent species. Emergent properties of both …

Editorial: C. Elegans Hostmicrobiome Interactions: From Medical To Ecological And Evolutionary Model, Michael A. Herman, Javier E. Irazoqui, Buck S. Samuel, Nic Vega

School of Biological Sciences: Faculty Publications

No abstract provided.

Editorial: C. Elegans Host-Microbiome Interactions: From Medical To Ecological And Evolutionary Model, Michael A. Herman, Javier E. Irazoqui, Buck S. Samuel, Nic Vega

School of Biological Sciences: Faculty Publications

Microbiomes often form specific functional associations with their hosts. Correlations between microbiome membership and states of host health and disease abound in many systems. However, there are few systems that allow for in depth functional studies that include precise manipulation and interrogation of both microbiome composition and host function. Recently the nematode Caenorhabditis elegans - an excellent genetic model organism for studying many fields of biology, including neurobiology and behavior, development, cell biology, and innate immunity - has proven to be a robust system to probe microbiome interactions and their effect on host physiology.

Multi-Omics Responses In Tree Swallow (Tachycineta Bicolor) Nestlings From The Maumee Area Of Concern, Maumee River, Ohio, Chi Yen Tseng, Christine M. Custer, Thomas W. Custer, Paul M. Dummer, Natalie Karouna-Renier, Cole W. Matson

United States Geological Survey: Staff Publications

A multi-omics approach was utilized to identify altered biological responses and functions, and to prioritize contaminants to assess the risks of chemical mixtures in the Maumee Area of Concern (AOC), Maumee River, OH, USA. The Maumee AOC is designated by the United States Environmental Protection Agency as having significant beneficial use impairments, including degradation of fish and wildlife populations, bird or animal deformities or reproduction problems, and loss of fish and wildlife habitat. Tree swallow (Tachycineta bicolor) nestlings were collected at five sites along the Maumee River, which included wastewater treatment plants (WWTPs) and industrial land-use sites. Polychlorinated …

Does Crime Trigger Genetic Risk For Type 2 Diabetes In Young Adults? A G X E Interaction Study Using National Data, Fangqi Guo, Kathleen Mullan Harris, Jason D. Boardman, Jennifer W. Robinette

Psychology Faculty Articles and Research

Background

Living in neighborhoods perceived as disordered exacerbates genetic risk for type 2 diabetes (T2D) among older adults. It is unknown whether this gene-neighborhood interaction extends to younger adults. The present study aims to investigate whether crime, an objectively measured indicator of neighborhood disorder, triggers genetic risk for T2D among younger adults, and whether this hypothesized triggering occurs through exposure to obesity.

Methods

Data were from the Wave I (2008) National Longitudinal Study of Adolescent to Adult Health. A standardized T2D polygenic score was created using 2014 GWAS meta-analysis results. Weighted mediation analyses using generalized structural equation models were conducted …

Association Of Hypomagnesemia And Liver Injury, Role Of Gut-Barrier Dysfunction And Inflammation: Efficacy Of Abstinence, And 2-Week Medical Management In Alcohol Use Disorder Patients., Evan J. Winrich, Khushboo S. Gala, Abhas Rajhans, Christian D. Rios-Perez, Amor J. Royer, Zarlakhta Zamani, Ranganathan Parthasarathy, Luis S. Marsano-Obando, Ashutosh J. Barve, Melanie L. Schwandt, Vatsalya Vatsalya

Faculty and Staff Scholarship

(1) We investigated the involvement of serum magnesium level in early alcoholic liver disease (ALD), gut barrier dysfunction, and inflammation in alcohol use disorder (AUD) patients; and lastly, the efficacy of 2-week abstinence and medical management to alleviate hypomagnesemia. (2) Forty-eight heavy drinking AUD patients (34 males (M)/14 females (F)) participated in this study. Patients were grouped by serum alanine aminotransferase (ALT) level (a marker of liver injury) as group 1 (Group 1 (Gr.1); ALT ≤ 40 U/L, 7M/8F, without any indication of early-stage ALD) and group 2 (Group 2 (Gr.2); ALT > 40 U/L, 27M/6F or early-stage ALD). These patients …

Tigit Is The Central Player In T-Cell Suppression Associated With Car T-Cell Relapse In Mantle Cell Lymphoma, Vivian Changying Jiang, Dapeng Hao, Preetesh Jain, Yijing Li, Qingsong Cai, Yixin Yao, Lei Nie, Yang Liu, Jingling Jin, Wei Wang, Heng-Huan Lee, Yuxuan Che, Enyu Dai, Guangchun Han, Ruiping Wang, Kunal Rai, Andrew Futreal, Christopher Flowers, Linghua Wang, Michael Wang

Faculty, Staff and Student Publications

BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and BA is the only CAR T-cell therapy approved by the FDA for MCL. However, development of relapses to BA is recognized with poor patient outcomes. Multiple CAR T-cell therapies have been approved for other lymphomas and the resistance mechanisms have been investigated. However, the mechanisms underlying BA relapse in MCL have not been investigated and whether any previously reported resistance mechanisms apply to BA-relapsed patients with MCL is unknown.

METHODS: To interrogate BA resistance mechanisms in MCL, we …

Il-6 And Tnf-Α Responses To Acute And Regular Exercise In Adult Individuals With Multiple Sclerosis (Ms): A Systematic Review And Meta-Analysis, Parnian Shobeiri, Homa Seyedmirzaei, Nastaran Karimi, Fatemeh Rashidi, Antônio L Teixeira, Serge Brand, Dena Sadeghi-Bahmani, Nima Rezaei

Faculty, Staff and Student Publications

Background: In both the general population and people with multiple sclerosis (PwMS), physical exercise is associated with improved mental well-being. Moreover, there is evidence of the possible protection of physical activity against disease progression in multiple sclerosis (MS). However, the question arises if acute or regular exercise has any impact on the immune system in PwMS. To answer this question, we performed a systematic review and meta-analysis on both plasma and serum cytokine levels (IL-6 and TNF-α) before and after acute and regular exercise among PwMS and compared to healthy controls.

Method: We performed an online search via PubMed, EMBASE, …

Green Synthesis Of Silver Nanoparticles From Diospyros Villosa Extracts And Evaluation Of Antioxidant, Antimicrobial And Anti-Quorum Sensing Potential, Ot Adu, Farzana Mohamed, Yougasphree Naidoo, Ts Adu, Hafizah Chenia, Yaser Hassan Dewir, Hail Rihan

School of Biological and Marine Sciences

The biosynthesis of silver nanoparticles (AgNPs) from Diospyros villosa leaves and stem bark extracts is described. The stem bark AgNPs of D. villosa synthesized at 80 °C (S80) showed good scavenging activity with a lower IC50 value of 8.75 µg·mL−1 compared to ascorbic acid (9.58 µg·mL−1). The total phenol content of the S80 AgNPs was measured and found to be 10.22 ± 0.14 mg.g−1 gallic acid equivalence (GAE). Bacterial growth inhibition (% GI) and violacein inhibition (% VI) of 10.08% and 58.83%, respectively, was observed against C.subtsugae CV017 with leaf AgNPs synthesized at 80 °C (L80) at 80 μg·mL−1. Stem …

Chimes: September 26, 2022, Calvin University

Chimes

Education majors adapt to post-pandemic teaching by Ezra Craker

Long lines as Dining Services copes with low staffing levels by Katie Rosendale

Introduction of new communication platform aims to solve old issues by Abigail Ham

CISD Scholars Program links students with mentors in their fields by Emily Thomas

Intramurals adjusts sign-up process to increase accessibility by Lauren Nyong

Analytical and intuitive: different cultural perspectives enhance religion classes by Gabriel Choi

Biology professor and team of undergraduates contribute to global search for HIV cure by David Ogboro

CPI graduates work to improve conditions in correctional facilities by Grace Buller

Diagnostic Accuracy Of Ultrasound In Predicting Extrathyroidal Extension And Its Relation To Body Mass Index In A North American Population, Mahmoud Omar, Abdallah S. Attia, Peter P. Issa, Bryce R. Christensen, Kavin Sugumar, Ahmed Alnahla, Deena Hadedeya, Hosam Shalaby, Neel Gupta, Mohamed Shama, Eman Toraih, Emad Kandil

School of Medicine Faculty Publications

Detection of extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) influences treatment plan and surgical aggressiveness. Ultrasound (US) is the long-standing preoperative imaging method of choice. Recent literature from Asia suggests US accuracy to be influenced by patient characteristics, such as body mass index (BMI). Here, we examine the effect of BMI on the accuracy of US at a North American tertiary referral center. A total of 204 PTC-confirmed patients were retrospectively read by a radiologist blinded to surgical pathology findings. The radiologist recorded multiple sonographic features, including ETE, loss of echogenic capsule, nodule vascularity, capsular abutment, and …

Anthropogenic Contaminants In Glacial Environments Ii: Release And Downstream Consequences, Dylan B. Beard, Caroline C. Clason, Sally Rangecroft, Ewa Poniecka, Kim J. Ward, Will H. Blake

School of Geography, Earth and Environmental Sciences

Anthropogenic contamination has been detected in glacial and proglacial environments around the globe. Through mechanisms of secondary release, these contaminants are finding their way into glacial hydrological systems and downstream environments, with potential to impact hundreds of millions of people who rely on glacial meltwater for water, food and energy security worldwide. The first part of our progress report outlined the sources and accumulation mechanisms of contaminants in glacial environments (Part I: Inputs and accumulation). Here we assess processes of contaminant release, pathways to downstream environments, and socio-environmental consequences. We reflect on the potential impacts these contaminants could have for …

Not The Same Cure: Student Experiences In Course-Based Undergraduate Research Experiences Vary By Graduate Teaching Assistant, Emma C. Goodwin, Jessica R. Cary, Erin E. Shortlidge

Biology Faculty Publications and Presentations

To expose all undergraduate science students to the benefits of participating in research, many universities are integrating course-based undergraduate research experiences (CUREs) into their introductory biology laboratory curriculum. At large institutions, the bulk of introductory labs are instructed by graduate teaching assistants (GTAs). Graduate students, who are often teachers and researchers in training, may vary in their capacity to effectively teach undergraduates via the CURE model. To explore variation in GTA teaching and the subsequent outcomes for students, we used a case study research design at one institution where introductory biology students participate in GTA-taught CURE lab sections. We used …

The Mood Of The Silver Economy: A Data Science Analysis Of The Mood States Of Older Adults And The Implications On Their Wellbeing, M Palomino, R Allen, F Aider, Fa Tirotto, I Giorgi, H Alexander, G Masala

School of Engineering, Computing and Mathematics

For the first time in the history of humanity, the number of people over 65 surpassed those under 5 in 2018. Undoubtedly, older people will play a significant role in the future of the economy and society in general, and technological innovation will be indispensable to support them. Thus, we were interested in learning how home automation could enable older people to live independently for longer. To better understand this, we held focus groups with UK senior citizens in 2021, and we analyzed the data derived from them from the perspective of affective computing. We have trained a machine learning …

Trending Anti-E7 Serology Predicts Mortality And Recurrence Of Hpv-Associated Cancers Of The Oropharynx, Luke Johnson, Dat T Ha, Melissa B Hall, Gregory Shoemaker, Paul A Bevins, John Strickley, Shadmehr Demehri, Rebecca A Redman, Joongho Joh

2020-Current year OA Pubs

High-risk human papillomavirus (HPV) is among the most common causes of head and neck cancer (HNC) with increasing incidence. HPV-associated HNC patients' clinical response to treatment varies drastically, which has made treatment de-escalation clinical trials challenging. To address the need for noninvasive biomarkers that differentiate patient outcomes, serum antibodies to E7 oncoprotein levels were evaluated in serial serum specimens from HPV-positive HNC patients (

The Material Properties Of A Bacterial-Derived Biomolecular Condensate Tune Biological Function In Natural And Synthetic Systems, Keren Lasker, Steven Boeynaems, Vinson Lam, Daniel Scholl, Emma Stainton, Adam Briner, Maarten Jacquemyn, Dirk Daelemans, Ashok Deniz, Elizabeth Villa, Alex S Holehouse, Aaron D Gitler, Lucy Shapiro

2020-Current year OA Pubs

Intracellular phase separation is emerging as a universal principle for organizing biochemical reactions in time and space. It remains incompletely resolved how biological function is encoded in these assemblies and whether this depends on their material state. The conserved intrinsically disordered protein PopZ forms condensates at the poles of the bacterium Caulobacter crescentus, which in turn orchestrate cell-cycle regulating signaling cascades. Here we show that the material properties of these condensates are determined by a balance between attractive and repulsive forces mediated by a helical oligomerization domain and an expanded disordered region, respectively. A series of PopZ mutants disrupting this …

Ensuring Health Security Of (Covid-19) Innovative Vaccines In The Light Of The Algerian And Comparative Legislations, Abid Abdelmoumen

مجلة جامعة الإمارات للبحوث القانونية UAEU LAW JOURNAL

Although the Corona Virus Pandemic has stimulated Innovation, Research and Development to explore potential Vaccines; however, the expeditious launch of any of these products in the Markets should not be done at the expense of Patient Safety. So, this paper focuses on understanding how Health Laws and Regulations interfere in order to protect the Patients Health Security and peoples who exposed to future (COVID19) Vaccinations, and that's in different Health Systems; we starting with the US health system, passing through the Algerian health system, reached to the European health system.

Exploring The Student Experience In An Asynchronous Virtual Introductory Biology Course, Eve Abraha, Lauren Crowe

Teaching and Learning Together in Higher Education

No abstract provided.

Creating Classrooms As Radical Spaces Of Possibility, Ryan Rideau

Teaching and Learning Together in Higher Education

No abstract provided.

Where’S The E In Oe? The Mcdonaldization Of Irish Outdoor Education, John Pierce, Simon Beames

Publications

This paper presents key findings from a study that aimed to critically examine the practice of outdoor education in the Republic of Ireland. It consisted of 10 months of fieldwork across four public Outdoor Education and Training Centres (OETCs). Data were generated through participant observation, informal conversation, as well as centre websites. Findings from the thematic analysis are presented in the form of a creative non-fiction story—principally to protect the identities and centres involved. The findings were then interpreted through the theoretical lens of McDonaldization. Considering the dearth of outdoor education research in Ireland, McDonaldization provided a lens through which …

Ecological Consequences Of Historic Moorland ‘Improvement’, Francis M. Rowney, Ralph M. Fyfe, Philip Anderson, Robert Barnett, William Blake, Tim Daley, Katie Head, Alison Macleod, Ian Matthews, David N. Smith

School of Geography, Earth and Environmental Sciences

No abstract provided.

Consciousness, Evaluation, And The Self-Organizing Brain

Journal of Conscious Evolution

While evolution is guided by natural selection, it is internally driven by self-organizing processes. The brain encompasses these complementary forces and dynamics of evolution in both its structure and dynamics by embodying a historical record of the factors that have shaped it throughout its evolutionary past, as well as by being shaped by selective parameters in real time. Self-organization is evident in not only the brain’s structure and form, but also in the processes that support consciousness. From the convergence of complex structure and the novelty-generating dynamics of chaos that both characterize the brain arises the experience of explicit consciousness, …