Digital Commons Network^™

Mechanistic Insights Into An Iron-Responsive Repressor, Fep1, From Schizosaccharomyces Pombe, Allison Nicole Kimsey

Theses and Dissertations

Iron is an essential metal cofactor required for a variety of biochemical pathways in most living organisms. In recent years, the nonpathogenic fungi Schizosaccharomyces pombe has been used to study iron regulation and uncover the molecular mechanisms for controlling intracellular iron levels. Some of these regulation pathways are conserved with those of pathogenic fungi, making these studies applicable for the future development of antifungals that target iron homeostasis. In S. pombe, the GATA-type transcriptional repressor Fep1 is responsible for repressing iron uptake genes during times of iron abundance. Previous reports have proposed that the binding of an iron-sulfur (Fe-S) …

Novel Dietary Index For Gut Microbiota And Associations With Colorectal Cancer And Breast Cancer Risk, Bezawit Eyob Kase

Theses and Dissertations

Introduction: Diet serves as a driving force for shaping the gut microbiome. Understanding how diet may modify gut microbiota and subsequently may be associated with chronic disease is critical to public health prevention efforts. Aims: We aimed to develop a novel dietary index that captures the quality of diet with respect to attaining beneficial composition and function of gut microbiota. We then examined the relationship between the dietary index and two gut microbiota-related cancers, i.e., colorectal and breast cancers.

Methods: We conducted a systematic review of studies that examined the effect of foods on gut microbiota in adult populations. Dietary …

Development Of Peptidomimetic Inhibitors Targeting The Polo Box Domain Of Plk1 As Potential Cancer Therapeutics, Jessy Mariam Stafford

Theses and Dissertations

PLK1 overexpression has shown to be associated with tumor progression and an unfavorable prognosis in a wide variety of cancer types. Interfering with PLK1 genetically and chemically induces apoptotic cell death in cancer cells thus confirming PLK1 as a validated anticancer target. From a drug discovery perspective, PLK1 offers two functionally distinct, essential, and interconnected target sites in one molecule. These are the ATP binding kinase domain (KD) and the unique Polo Box Domain (PBD), where the interplay between these results in dynamic structural regulation of catalytic activity and sub cellular localization. Since the KD is conserved among kinases and …

Characterization Of The Interaction Between Grx4-Bol2 And The Iron-Responsive Transcription Factor Aft1 In Candida Glabrata, Evan A. Talib

Theses and Dissertations

Iron is an indispensable protein cofactor that plays a critical role in biological functions such as cellular respiration. However, excess iron causes cellular damage via the generation of reactive oxygen species. To obtain optimal intracellular iron levels, eukaryotic cells have developed mechanisms to tightly regulate iron levels. The molecular mechanism for iron regulation in the pathogenic yeast Candida glabrata has not yet been explored, although this yeast bears iron regulation pathways that are very similar to the model yeast Saccharomyces cerevisiae. Understanding how C. glabrata regulates iron levels is critical for the treatment of infections caused by this opportunistic …

Identifying Racial Differences In Colorectal Polyp Profile At Screening Colonoscopy Using Traditional Regression And Machine Learning Approaches, Yuqi Wu

Theses and Dissertations

Background

Colorectal cancer (CRC), the second leading cause of cancer and cancer deaths in the United States, can largely be prevented by screening the age-appropriate adult population with colonoscopy to remove precancerous lesions. However, despite the encouraging annual, population-wide decline in CRC incidence and mortality in recent decades, and widespread adoption of screening colonoscopy since 2000 (~60% population coverage rate), the Black population has consistently suffered higher CRC incidence and mortality than Whites, currently 20% and 40% respectively, little changed from the 2000 rats of 26% and 52%.

The reason for this is thought to be that the Black population …

Sleep Challenges And Temperament Among Infants At Elevated Likelihood Of Autism Spectrum Disorder, Miranda Hope Foster

Theses and Dissertations

The current study used parent report in a prospective longitudinal design to examine the relationship between early sleep difficulties and temperament among infants with an older sibling diagnosed with ASD (EL-ASIB, n = 32), those born pre-term (EL-PT, n = 24) and those with no familial history of ASD (LL, n = 28) across the first year of life. At 3, 4, 6 and 12 months, caregivers completed the Short Form of the Infant Behavior Questionnaire-Revised (IBQ-R) (Putnam et al., 2014). To understand how sleep difficulties are related to temperament, a new scale of Sleep Challenges was created with items …

“Even The Little Things Matter:” A Phenomenological Study On Factors Impacting Student Motivation During And After Covid-Related Disruptions In Education, Jennifer Ferris-Crisafulli

Theses and Dissertations

The COVID-19 pandemic brought about unprecedented disruptions in education, as schools were forced to make a rapid transition to virtual learning in March 2020. Students’ motivation seemed to decline significantly during and after this virtual learning period, which ranged from months to over a year in various areas of the United States. This study seeks to understand the factors impacting student motivation during and after this virtual learning period.

This action research study was conducted using a qualitative, phenomenological approach. Data was collected from open-ended surveys and semi-structured interviews during Spring 2021 and Spring 2022. Data was analyzed through the …

Implementing A Technology-Based Instructional Module In An Introduction To Engineering Course: The Impact On Student’S Vocabulary Retention And Attitudes Towards Learning, Robin T. Amick

Theses and Dissertations

The purpose of this study was to evaluate the academic impact of a technology-based instructional module for content vocabulary instruction in the Project Lead the Way (PLTW) Introduction to Engineering course. The goal of the study was to answer two key questions: 1) How does implementing a technology-based instructional module impact Engineering vocabulary academic gains for students taking the Introduction to Engineering course? and 2) What is the effect of implementing a technology-based instructional model on attitudes towards learning Engineering vocabulary for students taking the Introduction to Engineering course? This study was conducted with Introduction to Engineering students (N …

Natural Variation Of Fructose-1,6-Bisphosphatase In Colias Butterflies, Andrea Blair Stokes

Theses and Dissertations

In a process known as the evolutionary recursion, it is possible to follow how adaptation affects natural selection at successive stages of a species’ life cycle. Through studying allele and genotype frequencies of enzymes in glycolysis, a central metabolic pathway, it is possible to document how polymorphisms can shift the evolving functionality of enzymes within or among species. Fructose-1,6-bisphosphatase (FBPase) is an enzyme in gluconeogenesis that converts fructose-1,6-bisphosphate to fructose 6- phosphate. It is also known to convert the unused amino acid carbon skeletons of glycolysis into glycogen storage. Appearing to play a vital role in the acquisition, storage, and …

Use Of Dic Measurements With Finite Element Models For Direct Heterogeneous Material Property Determination And Wrinkle Formation During Automated Fiber Placement, Sreehari Rajan Kattil

Theses and Dissertations

In this work, application of DIC in combination with finite element modeling is demonstrated for efficient material characterization for complex heterogeneous materials and tow wrinkle formation during automated fiber placement.

The first part of the work describes the integration of DIC measurements with finite element models for direct property identification in heterogeneous material systems. The material property identification is based on solving partial differential equations (PDE) of equilibrium for unknown elastic material properties with known boundary conditions and full field strain data (Eg. DIC). The PDEs are solved numerically using Petrov-Galerkin finite element procedure. The classical Bubnov-Galerkin method is shown …

Applications Of Machine Learning For Improved Patient Selection And Therapy Recommendations, Brendan Elochukwu Odigwe

Theses and Dissertations

The public health domain continues to battle with illness and the growing need for continuous advancement in our approach to clinical care. Individuals experiencing certain conditions undergo tried and tested therapies and medications, practices that have become the mainstay and standard of care in clinical medicine. As with all therapies and medications, they don't always work the same way and do not work for everyone. Some Treatment regimens, like Hydroxyurea medication, which is commonly administered to Sickle cell anemia patients, come with some adverse side effects due to the chemotherapeutic nature of the drug. This would be particularly disappointing if …

A Holistic Approach To Culturally Relevant Education In Biology To Examine Student Engagement, Robyn Brooke Biery

Theses and Dissertations

Recognizing that many students were disengaged in my grade-level biology class, this study sought to improve student engagement as a result of the implementation of CRE-enriched instruction and to describe themes associated with CRE and engagement. This qualitative action research study used a survey, exit tickets, and observations to discover emergent themes as a result of implementing CRE-enriched lessons. This action research study used member checking and disconfirming evidence to increase rigor and transferability. The results were that the use of CRE-enriched lessons increased the engagement of grade-level students in biology, and that engagement requires a two-pronged approach – cultural …

Peromyscus Maniculatus Bairdii And Peromyscus Maniculatus Sonoriensis Polymorphisms, Matthew Dixon Lucius

Theses and Dissertations

Sequencing technology has advanced greatly over the past couple of decades. This has led to many studies developing hypotheses based on genomic data. This requires many genomic studies to have up-to-date information on the species’ or subject’s genome being investigated. If a study does not have accurate or up-to-date background information, then they cannot fully develop their theories that are being established. In this study, I utilize outbred Peromyscus maniculatus, deer mice that are genetically diverse, to record the polymorphisms that are found throughout the Peromyscus maniculatus genome. I first explore the differences between the polymorphisms found in Peromyscus …

Too Feminine For Execution?: Gender Stereotypes And The Media’S Portrayal Of Women Sentenced To Death, Kelsey M. Collins

Theses and Dissertations

Traditional gender norms prescribing women as more nurturing and less aggressive than men have led to both the reluctance to view women as capable of violence, as well as a greater willingness to execute men than women in the United States. To make sense of the instances where women are sentenced to death, the media often pathologizes and/or demonizes them. Scholars have found that demonizing and dehumanizing those executed is a necessity to the implementation of capital punishment, both in cases of male and female defendants. To better understand how the news media have framed the gender and racial narratives …

Decellularization Strategies Of Naturally Derived Biomaterials For Tissue Engineering Applications, Julia Elizabeth Hohn

Theses and Dissertations

In 2017, over 3.5 million peripheral vascular surgeries were performed worldwide with over 400,000 vascular repair or replacement surgeries being performed in the United States each year alone. As the number of vascular repair surgeries, including both coronary and peripheral bypass grafting procedures, continues to increase each year, these statistics indicate an urgent need for more effective and readily available replacement materials. Regenerative medicine and tissue engineering (TE) approaches, including the design, fabrication, and validation of suitable biomaterials in vitro that direct the repair and regeneration of damaged tissues, have been proposed to alleviate this problem. While advanced biomaterials have …

Sources And Cycling Of Neodymium And Rare Earth Elements In The Arctic Amerasian Basin And Bering Sea, Brian D. Duggan

Theses and Dissertations

The isotopic composition of dissolved neodymium (¹⁴³Nd/¹⁴⁴Nd, expressed as εNd) behaves quasi-conservatively in the ocean and has been used as a palaeoceanographic tracer of ocean circulation. The εNd value of water masses is acquired—and often altered—during interaction with sediments along the margins; however, the processes involved in seawater εNd acquisition remains poorly characterized and quantified. Here we report the results of 349 Nd isotope and 354 rare earth element (REE) concentration measurements from 27 water column profiles across the Bering shelf and through the Arctic Amerasian Basin collected during U.S. Arctic GEOTRACES cruise HLY1502 (GEOTRACES section …

Collaborative Problem-Solving And Its Impact On Inclusive Practices, Confidence, And Beliefs Of General Education Teachers In Colombia, Shannon Renee Elmore

Theses and Dissertations

The purpose of this mixed-methods action research study was to examine the impact of a collaborative problem-solving process on the inclusive practices, confidence, and beliefs of general education teachers at a private bilingual school in Bogotá, Colombia. The problem of practice this research aims to address is the challenge teachers face in meeting the needs of a diverse student population with the increasing inclusion of exceptional learners in the general education classroom and a lack of preparation during teacher training programs. Grounded in Vygotsky’s social constructivism and Wenger’s communities of practice, this dissertation explores how teacher collaboration can lead to …

Xenobiotic Exposures On Women’S Reproductive Health, Maria Zubizarreta Mcclam

Theses and Dissertations

Environmental and chemical exposures are continually introduced into our bodies. The female reproductive cycle is complex and particularly sensitive to toxic substances. A recent rise in infertility and reproductive diseases and cancers make reproductive toxicity a public health concern. The overall purpose of this dissertation is to explore how environmental and chemical exposures impact women’s reproductive health and overall wellbeing. To do this, a variety of topics related to women’s reproductive health are explored, including how environmental exposures can impact reproduction, methods for studying reproductive dysfunctions, fertility preservation among cancer patients, and the overall wellbeing of female cancer patients.

The …

Arctic Ocean And Subarctic Seas Dynamics In A Changing Climate, Sarah B. Hall

Theses and Dissertations

Salinity is the primary determinant of the Arctic Ocean’s vertical density stratification in the upper ocean, which has major implications on the ocean’s physical dynamics alongside a period of rapidly declining sea ice. In recent decades, the Arctic’s freshwater content (FWC) has increased as a result of the accumulation of freshwater source inputs. Additional freshwater exported to the North Atlantic may hinder overturning processes that are vital to the regulation of global climate. This dissertation employs in situ measurements, satellite observations, and ocean model simulations to better understand salinity and freshwater changes in the Arctic Ocean during this changing climate. …

Gratitude Buffers The Effects Of Stressful Life Events On Early Adolescents’ Life Satisfaction And Externalizing Behaviors But Not Internalizing Behaviors, Mimi Scott Webb

Theses and Dissertations

Identifying psychological strengths that foster healthy development in youth has become a topic of exploration in the field of positive psychology (e.g., Suldo & Huebner, 2004; Valle et al., 2006). Gratitude is a promising trait-like characteristic with qualities indicative of a potential psychological strength that may serve as a protective factor for early adolescents in the face of stressful life events. This study utilized data from a sample of 1,880 middle school students from the Southeastern United States. Hierarchical regression analyses investigated gratitude’s role as a moderator in the relationship between stressful life events and adolescent well-being. Specifically, gratitude’s ability …

Perceived Sexual Intent: Power, Relationship Status, And Gender, Joseph Eric Padgett

Theses and Dissertations

Does lacking power cause people to think potential partners are less interested in engaging with them sexually? Do men and women perceive the interests of potential sex partners differently? Does the amount of sexual intent perceived by people who are in a romantic relationship differ from that of singles? Power has been shown to impact perceptions in other contexts, and the way people rate the attractiveness of potential mates is shown to differ depending upon their own relationship status. Similarly, gender differences are a central theme in discussions of sex related perceptions, preferences, and behaviors. In this study, I utilize …

Adherence To Screening And Management Guidelines Of Maternal Group B Streptococcus Colonization In Pregnancy, Sabine Pangerl, Deborah Sundin, Sadie Geraghty

Research outputs 2022 to 2026

Aims: To investigate Group B Streptococcus (GBS) colonization in pregnancy; adherence to antenatal GBS screening and adherence to the intrapartum antibiotics protocol within two models of care (midwifery and non-midwifery led). Design: This retrospective quantitative study has employed a descriptive design using administrative health data. Methods: Data from five maternity hospitals in metropolitan and regional Western Australia that included 22,417 pregnant women who gave birth between 2015 and 2019 were examined, applying descriptive statistics using secondary data analysis. Results: The study revealed an overall GBS colonization rate of 21.7% with similar rates in the different cohorts. A lower adherence to …

Colorblind Capture, Jonathan Feingold

Faculty Scholarship

We are facing two converging waves of racial retrenchment. The first, which arose following the Civil Rights Movement, is nearing a legal milestone. This term or the next, the Supreme Court will prohibit affirmative action in higher education. When it does, the Court will cement decades of conservative jurisprudence that has systematically eroded the right to remedy racial inequality.

The second wave is more recent but no less significant. Following 2020’s global uprising for racial justice, rightwing forces launched a coordinated assault on antiracism itself. The campaign has enjoyed early success. As one measure, GOP officials have passed, proposed or …

Redbird Scholar, Vol. 8, No. 1 (Fall 2022), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

Psycaria - Emotion Detector For A Psychiatrist, Ayesha Anees Zaveri, Mobeen Nazar, Nabiha Faisal, Sarama Shehmir, Misbah Parveen, Naveera Sami

Malaysian Journal of Computing (MJoC)

Every person will experience stress around the world, some healthy, called EUSTRESS and some unpleasant, named DISTRESS. Good pressure and stress promote success. Stress damages people's lives and health and causes various diseases. On the other hand, psychiatrists have a hard time treating their patients owing to a lack of time. They need innovative and intelligent equipment to treat their patients. We prepared a device that can detect a person's POSITIVE and NEGATIVE emotions through a smartwatch and a gadget that can sense body temperature, respiration, and heart rate. After witnessing these parameters, it can store the results on a …

The Relationship Between Socioeconomic Factors With Fertility Rate In Malaysia, Ahmad Muadz Zulqarnain, Mazlynda Md Yusuf

Malaysian Journal of Computing (MJoC)

The issue of an ageing population is on the rise globally, and Malaysia is not excluded from facing this issue. Past literature has recognized that the declining fertility rate is one of the main factors that lead to this problem. However, along with the declining fertility rate in Malaysia over time, there are also changes in social and economic factors such as increment in female labor participation, higher house income and consumption expenditure, increasing inflation and changes in the demographic of the population. The study has become a concern since these factors could affect the declining fertility rate. Hence, this …

Spongy Moth [Fact Sheet], Rachel Maccini

UNH Cooperative Extension

No abstract provided.

Sticky Me: Self-Relevance Slows Reinforcement Learning, M Golubickis, Cn Macrae

School of Psychology

A prominent facet of social-cognitive functioning is that self-relevant information is prioritized in perception, attention, and memory. What is not yet understood, however, is whether similar effects arise during learning. In particular, compared to other people (e.g., best friend) is information about the self acquired more rapidly? To explore this matter, here we used a probabilistic selection task in combination with computational modeling (i.e., Reinforcement Learning Drift Diffusion Model analysis) to establish how self-relevance influences learning under conditions of uncertainty (i.e., choices are based on the perceived likelihood of positive and negative outcomes). Across two experiments, a consistent pattern of …

Risk Factors Of Cyberbullying Victimization: The Impact Of Developmental Trauma, Yuliya Mykytyn

Dissertations

Trauma has been considered as one of the significant causes of psychological distress, especially if the traumatic event occurred in the childhood. At the same time, due to wide popularity of social media as a source of communication, cyberbullying emerged as a new way to harass someone, with specific focus on adults and young adults. The area of focus of this research project is to investigate whether experienced trauma, specifically developmental trauma might serve as a risk factor for cyberbullying victimization. Additional focus was on the differences in traumatic experiences and their impact for people with diverse cultural and ethnic …

Peeps: A Relational Framework For Incorporating Resilience Into Community-Based Programming For Youth, Christine Leistner, Shelley Hart

Journal of Youth Development

Youth in communities across the world are exposed to adversity and trauma at high levels. In this article, we describe a research-informed, resilience-promoting framework that can be incorporated into a variety of touch points for youth (e.g., school, family, community, extra-curricular activities). The PEEPS Framework is relational in nature and includes the following five interconnected components: (a) positive adult relationships, (b) esteem, (c) empathy, (d) peer relationships, and (e) strengths-based approach. We outline the research that supports each component, describe how we are currently implementing the PEEPS framework in the form of a volunteer training, and offer research-based suggestions for …