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Detailing The Effects Of Cbd On Parp And Survivin Expression In Ewing Sarcoma, Tyler Carter

Theses

Ewing sarcoma (ES) is an aggressive pediatric bone cancer with low five-year survival rates, particularly with recurrent disease because ES often becomes resistant to chemotherapy in these recurrences. Cannabidiol (CBD) has been identified as a potentially promising therapeutic for patients with ES. In other cancer types, CBD has demonstrated effects on two major proteins that contribute to chemotherapy resistance. The first, Poly (ADP-ribose) Polymerase I (PARP1), is a DNA damage repair enzyme that is overexpressed in recurrent ES. Though chemotherapy induces DNA damage in these cancer cells, the high levels of PARP1 facilitate repair of the DNA, allowing the mutated …

Testing Ssa4::Ade3 Reporters For Mcs Screening, Chloe Ledford, Rebecca Adams Phd

Science University Research Symposium (SURS)

Gene expression is essential to life and occurs through the processes of transcription of mRNA in the nucleus, export of transcripts to the cytoplasm through the nuclear pore complex (NPC), and translation of the mRNA into protein in the cytosol. The budding yeast S. cerevisiae is a eukaryotic model system used to explore the regulation of mRNA export. Transcripts are able to exit the nucleus through interaction with Mex67 which binds mRNA via adaptor proteins and allows crossing through NPCs. However, during heat shock (42°C) known adaptor proteins are rendered dysfunctional thus halting general mRNA export. Under these conditions, specific …

Bat House Environmental Factors Affecting Bat Activity, Kim Nguyen, Harsh Patel

Science University Research Symposium (SURS)

A bat house helps play a vital role in survival and providing optimal roosting conditions for bats. The conditions when setting up a bat house have varying effectiveness in the success of bat occupancy and activity. In this study, many elements, such as environmental factors, placement of bat houses, and materials used, were observed with differing levels of significance regarding bat activity to find the most notable factors for a thriving bat house. Three different parks in Nashville, Tennessee, and their corresponding bat house were observed to measure how these factors would affect bat activity for the vastly different areas. …

(Si10-056) Fear Effect In A Three Species Prey-Predator Food-Web System With Harvesting, R. P. Gupta, Dinesh K. Yadav

Applications and Applied Mathematics: An International Journal (AAM)

Some recent studies and field experiments show that predators affect their prey not only by direct capture; they also induce fear in prey species, which reduces their reproduction rate. Considering this fact, we propose a mathematical model to study the fear effect of a middle predator on its prey in a three-species food web system with harvesting. The ecological feasibility of solutions to the proposed system is guaranteed in terms of positivity and boundedness. The local stability of stationary points in the proposed system is derived. Multiple co-existing stationary points for the proposed system are observed, which makes the problem …

Reconsidering “Romanesque” Art Through The Pilgrim’S Body: The Migrating Art Historians Project Five Years Later, Ivan Foletti, Martin F. Lešák

Peregrinations: Journal of Medieval Art and Architecture

No abstract provided.

Freeman Honors Newsletter, Fall 2022 Issue, Texas Southern University, Thomas F. Freeman Honors College

Honor's College Newsletters

Fall 2022 Newsletter

Illuminated Magazine, School Of Graduate Studies, East Tennessee State University

Illuminated: Graduate Student Research Magazine

From The Graduate School; Smoothing out the “Wrinkles” in Plant Oil Biosynthesis: How Gene Expression of Wrinkled2 can Increase Production and Improve Health Qualities of Plant-Derived Oils, [Jyoti Behera, PhD, Biomedical Sciences]; Where are They Now? [Featuring: Andrew Demczuk]; Club vs. Country: Are Portuguese American Soccer Fans More Loyal to their Club Team or their National Team?, [David Antunes, EdD, Global Sports Leadership]; Where are They Now? [Featuring: Monique Richard]; Eavesdropping on Plant Communication: Tracking the Movement of Phytosulfokines Stress Signals in Plants, [Bernard Abakah, MS, Chemistry]; Where are They Now? [Featuring: Paul Archie]; Assessing the State of Substance …

Reducing Prejudice Through Law: Evidence From Experimental Psychology, Sara Emily Burke, Roseanna Sommers

University of Chicago Law Review

Can antidiscrimination law effect changes in public attitudes toward minority groups? Could learning, for instance, that employment discrimination against people with clinical depression is legally prohibited cause members of the public to be more accepting toward people with mental health conditions? In this Article, we report the results of a series of experiments that test the effect of inducing the belief that discrimination against a given group is legal (versus illegal) on interpersonal attitudes toward members of that group. We find that learning that discrimination is unlawful does not simply lead people to believe that an employer is more likely …

Uni Schedule Of Classes: Policies And Procedures, Fall 2022, University Of Northern Iowa

UNI Schedule of Classes

A listing and schedule of the courses being taught as well as policies and procedures concerning attending classes at the University of Northern Iowa.

The Effect Of Universal Design For Learning On Student Engagement And Achievement In A Southwest Missouri School District, Amber D. Hainline

Dissertations

The researcher’s primary purpose in this mixed-method study was to investigate if teachers who applied Universal Design for Learning (UDL) to a unit of study noted increased engagement in students overall and in teacher-identified students considered “disengaged” compared to students in the same unit of study without the UDL methods applied. Additionally, the researcher sought to determine if students in a UDL course had more significant achievement than students in the same unit of study without the UDL framework applied. Primarily, the researcher aimed to ascertain if UDL would benefit the participating district's students, particularly those not utilizing special services. …

How Elevation Affects Epiphyte Distribution: An Analysis In Epiphyte Distribution Changes At Different Elevations And Tree Strata In Santa Lucia Cloud Forest Reserve, Ecuador, Nicole L. Melnick

Independent Study Project (ISP) Collection

Cloud forests are unique ecosystems due to their tropical nature, high elevations, and extremely high presence of epiphytes that serve many important roles for the ecosystem’s biotic and abiotic components. As epiphytes can make up anywhere from one-quarter (Foster 2001) to a half (Gómez González et al. 2017) of all local plant species in cloud forests, it is essential to understand how their habitat distributions change with elevation and whether climate change will have a significant effect on that. This study used observational survey methods to record the amount of monocots (separately counted bromeliads and orchids), dicots, ferns, and percent …

Orb-Weaver Diversity And Niche Partitioning In Ecuador’S Amazonian Foothills: What Spiders Can Reveal About Tree Fall Gaps, Streams, And Cultivated Areas, Riley Endries

Independent Study Project (ISP) Collection

As abundant predators at the top of arthropod food chains, spiders are excellent bioindicators. Araneae is a megadiverse and extremely understudied order, especially in the tropics. This study aims to investigate the diversity of orb-weaver spiders across a disturbance gradient and variety of habitat types as well as their microhabitat preferences and potential niche partitioning. Spider collection was performed on spiders of the families Araneidae, Tetragnathidae, and Theridiosomatidae in Sumak Kawsay in Situ biological reserve in the lower elevation cloud forest of Ecuador’s Andean foothills. Spiders and webs were observed and analyzed from primary and secondary forest tree fall gaps, …

Arthropod Assemblages At The Intersection Of Epiphyte And Soil Habitats: An Assessment Of Understory Level Nonvascular Epiphyte Communities And Their Connectivity Within A Tropical Montane Rainforest, David “Max” Jones

Independent Study Project (ISP) Collection

Canopy arthropods communities represent a disproportionate amount of global species richness (Stuntz 2001). Understanding arthropod composition and connectivity of lower epiphyte communities is important in understanding how canopy arthropods communities are formed and will respond to change (Floren and Linsenmair 1998). As such this study examined arthropod assemblages living within nonvascular epiphyte communities (epiphyte mats) living directly upon lower trunk regions of 24 trees in a tropical montane rain forest within the Santa Lucia Nature Reserve in Pichincha, Ecuador. Trees were assessed for size, epiphyte diversity, and epiphyte coverage before arthropod sampling within the epiphyte mats. Soil assessments were taken …

The Nesting Behavior Of Russet-Backed Oropendola On Sumak Allpa, Ecuador: An Analysis Of Nest Construction And Interactions With Competing Species, Claire Molina

Independent Study Project (ISP) Collection

Nests are the literal place of birth of bird species; they are incredibly important in the survival and reproduction of populations. Therefore, nesting behavior is a gateway into the lives and success of the animals. With the degradation of natural landscapes due to human activity, there is more of a need to monitor these nests to ensure healthy inhabitants. The Russet-backed Oropendola (Psarocolius angustifrons) creates unique, pendulous nests that are subject to piracy, parasitism, and predation; as well as weather phenomenon’s such as wind and rainstorms. This study describes the nest construction behavior, nest materials and nest architecture by collecting …

Tree To Tree: Phylogenetics Of Diverse Anura Using Portable Lab Equipment: Primer Optimization, Bioinformatic Pipeline, And Phylogenetic Analyses Reveal Potential New Species And Ability To Identify Evolutionary Relationships In A Hyper Diverse Anura Clade Using Nanopore Sequencing, Elinor Sterner

Independent Study Project (ISP) Collection

The Corredor Llanganates-Sangay is an extremely significant region for conservation, coined a “gift to the earth” by the World Wildlife Fund. Understanding amphibians species and populations is key due to their roles as hyper sensitive bioindicators. In recent years, portable sequencing equipment (Mini PCR thermocyclers, Oxford Nanopore Technology’s MinION sequencer, etc) make genetic data collection in remote areas possible, greatly increasing potential for conservation genetics and genomics. This study uses portable equipment to sequence two mitochondrial loci in 104 Anuran samples collected in four sites in the Corridor and presents phylogenies of each gene as well as a concatenated phylogeny. …

The Future Of Architecture: Measuring The Sustainability Of Paradigm Shifting Architectural Interventions, Jake M. Cohen

Independent Study Project (ISP) Collection

Sustainable development in the built environment seems paradoxical given that the architecture, construction, and buildings sector is one of most polluting, wasteful, and inefficient industries. Despite this notion, the role of the architect is evolving and their influence on design is expanding beyond ideas for physical structures and into designing interactions between the built environment and components such as policy, material usage, sustainability, and urban regeneration. Architects that are able to implement paradigm shifting design ideas that improve the environmental, social, and economic dimensions of sustainability can be catalytic for systemic change and act as a vehicle to move away …

The Viability Of Traditional Portuguese Olive Groves In The Alentejo Region Under A Sustainable Development Framework, Sydney Soloway

Independent Study Project (ISP) Collection

Portugal became self-sufficient in olive oil production in 2014 and produces 150% of its needs, which makes Portugal the world’s fourth-largest exporter (DeAndreis, 2022). Olive groves in Portugal were once estimated to be 70-80% low-input traditional type, but rapid intensification toward a predominantly intensive mode of agriculture has been extremely fast (Beaufoy, 2001, p. 22; Silveira et al., 2018, p. 248). The Alentejo region, despite its dry Mediterranean climate and a tradition of extensive, multi-functional agricultural systems, is now home to 85% of Portugal’s olive groves and responsible for 77% of the country’s olive oil production (Dawson, 2019; Silveira et …

Regenerative Agriculture Framework For Island Ecosystems Using São Miguel As A Case Study, Mya Hunter

Independent Study Project (ISP) Collection

Context: Regenerative agriculture is a farming approach that uses soil health as the entry point to contribute to multiple objectives, such as improved nutrient cycling and climate regulation. Farmers can apply different practices to reach these objectives. The objectives and practices, however, are not equally relevant or applicable for farming systems on island ecosystems and the local context.

Objectives: The main objective of this paper, therefore, is to find out how solutions towards regenerative agriculture can be identified and evaluated as such that they result in meaningful advice for farmers on island ecosystems in order to mitigate the …

Afforestation And Biodiversity: Bryophyte Richness Changes Between Icelandic Forest Types, Kian Mcdonough

Independent Study Project (ISP) Collection

Forest-dwelling bryophytes (mosses, liverworts, hornworts) greatly contribute to biodiversity and ecosystem function but are largely under-studied in comparison to vascular plants. With Iceland’s large-scale afforestation efforts there is a need to understand how different afforestation species are affecting biodiversity, including bryophyte diversity. This study looked at differences in ground-floor bryophyte richness across Sitka spruce, lodgepole pine, and downy birch forests and found that bryophyte richness was highest in the Sitka spruce forests and lowest in downy birch forests. While this suggests a negative correlation between bryophyte richness and light availability, since the conifer species have the densest copy cover, other …

Investigating Primary Succession Following The Retreat Of The Breiðamerkurjökull Glacier, Iceland, Ella Roelofs

Independent Study Project (ISP) Collection

The accelerating rates of glacier retreat around the world as a result of climate change make the study of primary succession in expanding forefields increasingly important. While this is a well studied topic in many parts of the world, little data exists specific to Iceland. This study investigated vegetation development along a chronosequence of eight time periods in the Breiðamerkurjökull outwash plain. Data was collected on percent vegetation cover, dominant species, the number of unique plant groups, and percent cover of five substrate types at 10 plots (0.55 x 0.55 m quadrats) per time period. Important findings include the fact …

How Does Theater Critically Engage With Contemporary Socio-Political Tensions? A Case Study On Neil Coppen And Mpume Mthombeni’S Isidlamlilo, Kami Zimmer

Independent Study Project (ISP) Collection

Historically, South African theater has utilized the stage as a platform to dismantle apartheid, pointing to its purposeful oppressive structure as the cause for much human suffering. In the 28 years since the dismantling of apartheid, contemporary South African theater has retained the same role, critically questioning the ways people are systematically disenfranchised. A need is surfacing, however, to address the causes for contemporary South African political disfunctions and societal inequities, other than apartheid. This study will focus on Isidlamlilo, a play written by Neil Coppen and Mpume Mthombeni in collaboration with their theater company Empatheatre, and will aim …

Medical Ethics: How Resource Distribution Affects The Decision Making Of Doctors In Rural India: An Explorative And Comparative Study In Jamkhed, Maharashtra, Jared Yee

Independent Study Project (ISP) Collection

Using rural Mahrasthra as a case study, I was able to explore the medical ethics and common dilemmas that occur in Rural India. Through a collection of interviews and articles, I was able to piece together my understanding of some common ethical challenges that India faces, emphasizing ones that were unique to the location and circumstance. Using observations I made through my work in the hospital, I learned that limited resources effects all sides of ethics in the medical field, with a significant effect on economics, hospital structure, and clinical protocol. In an attempt to source the aspects of Indian …

Laguncularia Racemosa Top-Layer Sediment Microorganism Makeup In Relation To Differing Levels Of Perceived Anthropogenic Impact In Bocas Del Drago, Bocas Del Toro, Panama, Gabrielle Glendening

Independent Study Project (ISP) Collection

As mangrove forests are destroyed by human factors across the earth, many crucial ecological processes that take place in these systems of trees are obstructed. One of the most important roles played by mangroves is their ability to sequester carbon in the sediment, as this storage of carbon helps diminish atmospheric warming. Many sediment microorganisms help in this process of carbon sequestration and play various other vital roles in mangrove ecosystems. Microorganisms in marine sediments can be used to assess the health of the surrounding environment. Past research has found significant differences in sediment microorganism composition, abundance, and diversity in …

Undergraduate And Graduate Course Descriptions, 2022 Fall, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Fall 2022.

The Extension Newsletter, Issue 110, Fall 2022, Wright State University Retirees Association

The Extension Newsletter

An eight page newsletter from the Wright State University's Retirees Association.

Ethyl Maltol, Vanillin, Corylone And Other Conventional Confectionery-Related Flavour Chemicals Dominate In Some E-Cigarette Liquids Labelled ‘Tobacco’ Flavoured, Esther E. Omaiye, Wentai Luo, Kevin J. Mcwhirter, James F. Pankow, Prue Talbot

Civil and Environmental Engineering Faculty Publications and Presentations

Background The increased popularity of electronic cigarettes (e-cigarettes) has been linked to the abundance of flavoured products that are attractive to adolescents and young adults. In the last decade, e-cigarette designs have evolved through four generations that include modifications in battery power, e-cigarette liquid (e-liquid) reservoirs and atomiser units. E-liquids have likewise evolved in terms of solvent use/ratios, concentration and number of flavour chemicals, use of nicotine salts and acids, the recent increased use of synthetic cooling agents and the introduction of synthetic nicotine. Our current objective was to evaluate and compare the evolving composition of tobacco-flavoured e-liquids over the …

Determining Suitable Green Biorefinery Locations In Ireland For Irish Agriculture Using Co-Design, Economic And Geographical Information Systems, Alice Hand

Theses

The aim of this thesis is to investigate potential locations for a suitable green biorefinery model in Ireland, which would offer an opportunity for sustainable diversification to grassland farmers. A mixed method approach was used to collect data to support the design and analyse a green biorefinery model. A three phased methodology was applied representing the Co-design, Economic and the Geographical Information Systems analysis phase. Key stakeholders identified in the co-design phase included farmers, cooperatives, market partners as having a direct impact on a biorefinery. This provided insight to the farmers preferred model. Using these findings, an economic assessment was …

Interviewed For Law And Other Things Podcast, Gauri Pillai, S Atrey

Popular Media

In this episode, our legal editor Eeshan Sonak is in conversation with Shreya Atrey and Gauri Pillai discussing their rewriting of Nergesh Meerza, which dealt with the constitutionality of Air India Employee Service Regulations. So without further delay, let’s dive right in.

A Simple Optical Fiber Spr Sensor With Ultra-High Sensitivity For Dual-Parameter Measurement, Farhan Mumtaz, Muhammad Roman, Bohong Zhang, Lashari Ghulam Abbas, Muhammad Aqueel Ashraf, Muhammad Arshad Fiaz, Yutang Dai, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

This work reports a simple optical fiber Surface Plasmon Resonance (SPR) sensor with ultra-high sensitivity for simultaneous measurement of the dual-parameter. The sensor is based on a D-shaped fiber with a nanolayer coating of Silver (Ag) and Hematite (α-Fe2O3). The Ag/α-Fe2O3 layer is deposited on the longitudinal surface of residual cladding, and a Fiber Bragg Grating (FBG) is inscribed on the single-mode fiber (SMF) for temperature compensation. The α-Fe2O3 layer protects the Ag layer from oxidation and effectively enhances the surface plasmon wave while interacting with free electrons. Finite Element Method (FEM) modeling is employed to investigate the refractive index …

Season‐Of‐Death And Age‐At‐Death Of The Easternmost European Cave Bears: Cementum And Dentine Increment Analysis Provides New Insight Into The Cave Bear Ecology, Natalya E. Prilepskaya, Olga P. Bachura, Gennady F. Baryshnikov

KIP Articles

Cementum and dentine increment analysis was used for the first time to study the remains of cave bears from European Russia, the Urals and the Caucasus. This study analysed 12 canines belonging to 12 different individuals (five males and seven females) from genetically different lineages of cave bears. The increment analysis showed that all studied cave bears belong to the categories adults and old animals (from 10 to 32.5 years). The enamel crowns of all 12 canines were broken and/or had wear facets. Seven canines studied were severely broken (more than one‐third of a canine crown missing). Significant damage to …