Digital Commons Network^™

Intensive Blood Pressure Lowering In Patients With Malignant Left Ventricular Hypertrophy, Simon B Ascher, James A De Lemos, Minjae Lee, Elaine Wu, Elsayed Z Soliman, Ian J Neeland, Dalane W Kitzman, Christie M Ballantyne, Vijay Nambi, Anthony A Killeen, Joachim H Ix, Michael G Shlipak, Jarett D Berry

Faculty, Staff and Students Publications

Background: Left ventricular hypertrophy (LVH) combined with elevations in cardiac biomarkers reflecting myocardial injury and neurohormonal stress (malignant LVH) is associated with a high risk for heart failure and death.

Objectives: The aim of this study was to determine the impact of intensive systolic blood pressure (SBP) control on the prevention of malignant LVH and its consequences.

Methods: A total of 8,820 participants in SPRINT (Systolic Blood Pressure Intervention Trial) were classified into groups based on the presence or absence of LVH assessed by 12-lead ECG, and elevations in biomarker levels (high-sensitivity cardiac troponin T ≥14 ng/L or N-terminal pro-B-type …

Elevated Nras Expression During Dcis Is A Potential Driver For Progression To Basal-Like Properties And Local Invasiveness, Ze-Yi Zheng, Hanan Elsarraj, Jonathan T Lei, Yan Hong, Meenakshi Anurag, Long Feng, Hilda Kennedy, Yichao Shen, Flora Lo, Zifan Zhao, Bing Zhang, Xiang H-F Zhang, Ossama W Tawfik, Fariba Behbod, Eric C Chang

Faculty, Staff and Students Publications

BACKGROUND: Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive. We have previously shown that NRAS is highly expressed selectively in basal-like subtypes of invasive breast cancers and can promote their growth and progression. In this study, we investigated whether NRAS expression at the DCIS stage can control transition from luminal DCIS to basal-like invasive breast cancers.

METHODS: Wilcoxon rank-sum test was performed to assess expression of NRAS in DCIS compared to invasive breast tumors in patients. NRAS …

Evaluation Of Invasive Avifauna Management Strategies In North America, Christopher L. Castillo

Great Plains Graduate Review

Human action has long been the cause of species introductions into new ecosystems (Lodge 1993). Now, these non-native species are a major global problem both ecologically and economically (Bled et al. 2011). Invasive species can alter habitats, decrease biodiversity, damage human settlements, and destroy agriculture (Townsend Peterson and Vieglais 2001; Kumschick and Nentwig 2010). The United States has been particularly affected by invasive introductions, a multitude of which have been avian species. Various management techniques have been implemented in order to control problem bird populations, however often times these methods are used with a ‘trial and error’ strategy. This review …

Note From The Editors, Mila Bednar, Tatiana Moore, Jada Ruff

Great Plains Graduate Review

No abstract provided.

Table Of Contents, Mila Bednar

Great Plains Graduate Review

No abstract provided.

Factors Impacting Multidisciplinary Team Communication And Patient-Centered Communication Along The Cancer Care Continuum, Jessica Beckham

Dissertations

The deployment of navigators as liaisons between cancer patients and their Multi-Disciplinary Teams (MDT) affords a high level of coordinated care that is otherwise difficult to attain. Highly functioning navigators provide a multitude of support roles, the primary being the dissemination and interpretation of information to and from patients and providers in a manner that is digestible to all recipients. Navigators face hurdles in the form of communication breakdowns within the MDT which can negatively impact level of care and lead to patient uncertainty. Patients face additional barriers of their own which serve to further heighten uncertainty and cause patients …

Patterns Of Population Structure And Introgression Among Recently Differentiated Drosophila Melanogaster Populations, Jenn M. Coughlan, Andrius J. Dagilis, Antonio Serrato-Capuchina, Hope Elias, David Peede, Kristin Isbell, Dean M. Castillo, Brandon S. Cooper, Daniel R. Matute

Nebraska Cooperative Extension: Faculty and Staff Publications

Despite a century of genetic analysis, the evolutionary processes that have generated the patterns of exceptional genetic and phenotypic variation in the model organism Drosophila melanogaster remains poorly understood. In particular, how genetic variation is partitioned within its putative ancestral range in Southern Africa remains unresolved. Here, we study patterns of population genetic structure, admixture, and the spatial structuring of candidate incompatibility alleles across a global sample, including 223 new accessions, predominantly from remote regions in Southern Africa. We identify nine major ancestries, six that primarily occur in Africa and one that has not been previously described. We find evidence …

Usa Archaeology Museum Newsletter - October 2022, Archaeology Museum

Archaeology Museum Newsletters

In this edition of the museum's newsletter:

October is Alabama Archaeology Month

• Upcoming events:

1. Alabama Department of Archives & History Food for Thought Lecture Series - Discovering Mabila

2. Alabama Department of Archives & History Food for Thought Lecture Series - Discovering Mabila: Watch Party

3. Archaeology of Down the Bay: The Old Water Street Site

4. A Very Batty Halloween at the Museum!

5. "Deforestation, Fire, & the Fate of Amazonia" with Dr. Gabriel De Oliveira

6. Down the Bay Photo Sharing Day

Insight - Fall 2022, Dugoni School Of Dentistry

Insight

Welcome to the autumn 2022 issue of Insight, a newsletter celebrating the accomplishments of our community of scholars. We aim to spotlight insights from people at the Dugoni School working in all areas of scholarship, including clinical or biomedical research, the scholarship of teaching and learning, improvement of the health care system, and professional partnerships that advance the field.

Comparative Behavioral Ecotoxicology Of Inland Silverside Larvae Exposed To Pyrethroids Across A Salinity Gradient, Sara J. Hutton, Samreen Siddiqui, Emily I. Pedersen, Christopher Y. Markgraf, Amelie Segarra, Michelle L. Hladik, Richard E. Connon, Susanne M. Brander

United States Geological Survey: Staff Publications

Pyrethroids, a class of commonly used insecticides, are frequently detected in aquatic environments, including estuaries. The influence that salinity has on organism physiology and the partitioning of hydrophobic chemicals, such as pyrethroids, has driven interest in how toxicity changes in saltwater compared to freshwater. Early life exposures in fish to pyrethroids cause toxicity at environmentally relevant concentrations, which can alter behavior. Behavior is a highly sensitive endpoint that influences overall organism fitness and can be used to detect toxicity of environmentally relevant concentrations of aquatic pollutants. Inland Silversides (Menidia beryllina), a commonly used euryhaline model fish species, were exposed …

Updated Perspectives On The Role Of Biomechanics In Copd: Considerations For The Clinician, Jennifer M. Yentes, Wai-Yan Liu, Kuan Zhang, Eric J. Markvicka, Stephen I. Rennard

Department of Electrical and Computer Engineering: Faculty Publications

Patients with chronic obstructive pulmonary disease (COPD) demonstrate extra-pulmonary functional decline such as an increased prevalence of falls. Biomechanics offers insight into functional decline by examining mechanics of abnormal movement patterns. This review discusses biomechanics of functional outcomes, muscle mechanics, and breathing mechanics in patients with COPD as well as future directions and clinical perspectives. Patients with COPD demonstrate changes in their postural sway during quiet standing compared to controls, and these deficits are exacerbated when sensory information (eg, eyes closed) is manipulated. If standing balance is disrupted with a perturbation, patients with COPD are slower to return to baseline …

Chemical Relaxers And Hair-Straightening Products: Potential Targets For Hormone-Related Cancer Prevention And Control, Adana A. M. Llanos, Jasmine A. Mcdonald, Dede K. Teteh, Traci N. Bethea

Health Sciences and Kinesiology Faculty Articles

"Emerging data show that use of permanent hair dyes, chemical relaxers, and straightening products might contribute to increased risk of hormone-related cancers (1-5) and potentially breast tumors with features indicative of more aggressive phenotypes (6). Given the wide use of these products globally, they are an important source of exposure to potentially harmful chemicals, including endocrine-disrupting chemicals—to which we are ubiquitously exposed (7)—and mutagenic and/or genotoxic compounds. The unequal burden of exposure across populations plausibly contributes to cancer inequities as the groups with the greatest exposure also experience poorer cancer outcomes (8). …

Intouch Week Of October 17, 2022, New York Medical College

InTouch

• 2022-2023 Social Media Ambassadors Set to Share an Inside Look At Their NYMC Experience
• Office of the Registrar Now Offers eTranscripts and CeDiplomas
• GSA Welcomes New Slate of Officers and Looks Forward to An Event-Filled Year
• StuHe Begins 2022-2023 Academic Year With Sights Set on Professional Development
• NYMC Nobel Laureate Connections
• GSBMS and SOM Establish Conditional Admittance Agreement
• NYMC Students and Faculty Provide Free Screenings At White Plains Health Fair

Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …

Effects Of A Nurse-Led Transitional Rehabilitation Programme (4cs-Tburp) For Adult Burn Survivors: A Randomized Controlled Trial, Jonathan Bayuo

Sigma Foundation for Nursing Research Grant Reports

The purpose of this study was to develop and evaluate the effects of a nurse-led transitional rehabilitation programme for adult burn survivors. Quality of life was the primary outcome of interest in this study. The secondary outcomes included sleep, pain, itchiness, scarring, psychological and physical role functioning.

Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …

Early Intervention With 3bnc117 And Romidepsin At Antiretroviral Treatment Initiation In People With Hiv-1: A Phase 1b/2a, Randomized Trial, Jesper D. Gunst, Marie H. Pahus, Miriam Rosás-Umbert, I-Na Lu, Thomas Benfield, Henrik Nielsen, Isik S. Johansen, Rajesh Mohey, Lars Østergaard, Vibeke Klastrup, Maryam Khan, Mariane H. Schleimann, Rikke Olesen, Henrik Støvring, Paul W. Denton, Natalie N. Kinloch, Dennis C. Copertino, Adam R. Ward, Winiffer D. Conce Alberto, Silke D. Nielsen, Maria C. Puertas, Victor Ramos, Jacqueline D. Reeves, Christos J. Petropoulos, Javier Martinez-Picado, Zabrina L. Brumme, R. Brad Jones, Julie Fox, Martin Tolstrup, Michel C. Nussenzweig, Marina Caskey, Sarah Fidler, Ole S. Søgaard

Biology Faculty Publications

Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this phase 1b/2a, open-label, randomized controlled trial using a four-group factorial design, we investigated whether early intervention in newly diagnosed people with HIV-1 with a monoclonal anti-HIV-1 antibody with a CD4-binding site, 3BNC117, followed by a histone deacetylase inhibitor, romidepsin, shortly after ART initiation altered the course of HIV-1 infection (NCT03041012). The trial was undertaken in five hospitals in Denmark and two hospitals in the United Kingdom. The coprimary endpoints were analysis of initial virus …

Could Annual Killifish Help Us Treat Macular Degeneration With Carmen Rodriguez, Carmen C. Rodriguez

PDXPLORES Podcast

In this episode of PDXPLORES, Carmen Rodriguez, a Ph.D. student in the biology department, discusses the Annual Killifish--a remarkable organism with the ability to survive long periods without oxygen or water--and how the unusual biology of this fish could unlock treatments for macular degeneration.

Click on the "Download" button to access the audio transcript.

Towards High Performing And Reliable Deep Convolutional Neural Network Models For Typically Limited Medical Imaging Datasets, Kaoutar Ben Ahmed

USF Tampa Graduate Theses and Dissertations

Artificial Intelligence (AI) is “The science and engineering of making intelligent machines, especially intelligent computer programs”. Artificial Intelligence has been applied in a wide range of fields including automobiles, space, robotics, and healthcare.

According to recent reports, AI will have a huge impact on increasing the world economy by 2030 and it's expected that the greatest impact will be in the field of healthcare. The global market size of AI in healthcare was estimated at USD 10.4 billion in 2021 and is expected to grow at a high rate from 2022 to 2030 (CAGR of 38.4%). Applications of AI in …

Generations: The University Of Mississippi Then And Now, Benita Whitehorn

University of Mississippi News

Four Black families share perspectives on their UM experience

High-Dielectric Pvp@Pani/Pdms Composites Fabricated Via An Electric Field-Assisted Approach, Huaixiao Wei, Yuan Yuan, Tianli Ren, Lijuan Zhou, Xueqing Liu, Haroon A.M. Saeed, Pingliang Jin, Yuwei Chen

Faculty Publications

Polymer-based composite films with multiple properties, such as low dielectric loss tangent, high dielectric constant, and low cost are promising materials in the area of electronics and electric industries. In this study, flexible dielectric films were fabricated via an electric field-assisted method. Polyaniline (PANI) was modified by polyvinylpyrrolidone (PVP) to form a core–shell structure to serve as functional particles and silicone rubber polydimethylsiloxane (PDMS) served as the matrix. The dielectric constant of the composites prepared under electric fields was improved by the micro-structures formed by external electric fields. With the addition of 2.5 wt% PVP@PANI, the dielectric constant could be …

Synthesis And Characterization Of New 1,3,4-Thiadiazole Derivatives: Study Of Their Antibacterial Activity And Ct-Dna Binding, Ekram Hany Mohamed

Pharmacy

1,3,4-Thiadiazole molecules (1-4) were synthesized by the reaction of phenylthiosemicarbazide and methoxy cinnamic acid molecules in the presence of phosphorus oxychloride, and characterized with UV, FT-IR, 13C-NMR, and 1H-NMR methods. DFT calculations (b3lyp/6-311++G(d,p)) were performed to investigate the structures' geometry and physiochemical properties. Their antibacterial activity was screened for various bacteria strains such as Enterobacter aerogenes, Escherichia coli ATCC 13048, Salmonella kentucky, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus and Gram positive such as Staphylococcus aureus ATCC 25923, Listeria monocytogenes ATCC 7644, Enterococcus faecium, Enterococcus durans, Staphylococcus aureus ATCC, Serratia marcescens, Staphylococcus hominis, Staphylococcus epidermidis, alfa Streptococcus haemolyticus, Enterococcus faecium and found …

Unfiltered: Endangered Species And Social Media, Sarah Schaier

UNH Today Archive

No abstract provided.

Cellular Landscaping Of Covid-19 And Gynaecological Cancers: An Infrequent Correlation, Rahul Bhattacharjee, Debanjan Das, Radheka Bhadhuri, Srija Chakraborty, Tanima Dey, Rupam Buragohain, Asim Nath, Kartik Muduli, Pranjan Barman, Rohit Gundamaraju

2020-Current year OA Pubs

COVID-19 resulted in a mortality rate of 3-6% caused by SARS-CoV-2 and its variant leading to unprecedented consequences of acute respiratory distress septic shock and multiorgan failure. In such a situation, evaluation, diagnosis, treatment, and care for cancer patients are difficult tasks faced by medical staff. Moreover, patients with gynaecological cancer appear to be more prone to severe infection and mortality from COVID-19 due to immunosuppression by chemotherapy and coexisting medical disorders. To deal with such a circumtances oncologists have been obliged to reconsider the entire diagnostic, treatment, and management approach. This review will provide and discuss the molecular link …

A Quantitative Metric Of Pioneer Activity Reveals That Hnf4a Has Stronger In Vivo Pioneer Activity Than Foxa1, Jeffrey L Hansen, Barak A Cohen

2020-Current year OA Pubs

BACKGROUND: We and others have suggested that pioneer activity - a transcription factor's (TF's) ability to bind and open inaccessible loci - is not a qualitative trait limited to a select class of pioneer TFs. We hypothesize that most TFs display pioneering activity that depends on the TF concentration and the motif content at their target loci.

RESULTS: Here, we present a quantitative in vivo measure of pioneer activity that captures the relative difference in a TF's ability to bind accessible versus inaccessible DNA. The metric is based on experiments that use CUT&Tag to measure the binding of doxycycline-inducible TFs. …

Il-1Β-Dependent Extravasation Of Preexisting Lung-Restricted Autoantibodies During Lung Transplantation Activates Complement And Mediates Primary Graft Dysfunction, Wenbin Yang, Daniel Kreisel, Et Al.

2020-Current year OA Pubs

Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD), although it remains unclear whether LRAs can drive its pathogenesis. In syngeneic murine left lung transplant recipients, preexisting LRAs worsened graft dysfunction, which was evident by impaired gas exchange, increased pulmonary edema, and activation of damage-associated pathways in lung epithelial cells. LRA-mediated injury was distinct from ischemia-reperfusion injury since deletion of donor nonclassical monocytes and host neutrophils could not prevent graft dysfunction in LRA-pretreated recipients. Whole LRA IgG molecules were necessary for lung injury, which was mediated by the classical and alternative complement pathways and …

Mapping The Distribution Of The Scarlet-Banded Barbet ( Capito Wallacei ) Using Geographic Information Systems ( Gis ) And Species Distribution Modeling ( Sdm ), Stephanie Marie Scherer

Theses and Dissertations

The Scarlet-banded Barbet (Capito wallacei) is a Neotropical barbet discovered in 1996 in the eastern Andean foothills of Peru. Despite being fairly common at the site of discovery, its known distribution is limited to two sites, and searching for other suitable sites is difficult in the wilderness of the eastern Andes. Through the use of geographic information sysems (GIS), remote sensing methods, and Maxent, we constructed a species distribution model (SDM) to determine the likelihood of occupancy of the Scarlet-banded Barbet outside of its current known distribution. The model predicted the occupancy with an area under the curve (AUC) of …

Scgwas: Landscape Of Trait-Cell Type Associations By Integrating Single-Cell Transcriptomics-Wide And Genome-Wide Association Studies, Peilin Jia, Ruifeng Hu, Fangfang Yan, Yulin Dai, Zhongming Zhao

Faculty, Staff and Student Publications

BACKGROUND: The rapid accumulation of single-cell RNA sequencing (scRNA-seq) data presents unique opportunities to decode the genetically mediated cell-type specificity in complex diseases. Here, we develop a new method, scGWAS, which effectively leverages scRNA-seq data to achieve two goals: (1) to infer the cell types in which the disease-associated genes manifest and (2) to construct cellular modules which imply disease-specific activation of different processes.

RESULTS: scGWAS only utilizes the average gene expression for each cell type followed by virtual search processes to construct the null distributions of module scores, making it scalable to large scRNA-seq datasets. We demonstrated scGWAS in …

The Mechanisms Of Action Of Tumor Treating Fields, Justin C Moser, Ellaine Salvador, Karina Deniz, Kenneth Swanson, Jack Tuszynski, Kristen W Carlson, Narasimha Kumar Karanam, Chirag B Patel, Michael Story, Emil Lou, Carsten Hagemann

Faculty, Staff and Student Publications

Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of …

The Effects Of A Unilateral Strength And Power Training Intervention On Inter-Limb Asymmetry And Physical Performance In Male Amateur Soccer Players, Francesco Bettariga, Luca Maestroni, Luca Martorelli, Paul Jarvis, Anthony Turner, Chris Bishop

Research outputs 2022 to 2026

The aims of this study were (a) to investigate the effects of a unilateral training program in reducing inter-limb asymmetry in male soccer players; (b) to explore such effects on measures of physical performance and unilateral inter-limb asymmetry. Twenty-four soccer players, randomly assigned to a 6-week unilateral strength and power training (UNI) (n = 12) or a control group (CON) (n = 12), performed single countermovement jump (SLCMJ), single leg broad jump (SLBJ), single leg drop jump (SLDJ), 10-m sprint, and 505 change of direction (COD) speed test. Raw jump scores revealed small to large improvements in SLCMJ, SLBJ, and …