Digital Commons Network^™

Neoplastic Cell Enrichment Of Tumor Tissues Using Coring And Laser Microdissection For Proteomic And Genomic Analyses Of Pancreatic Ductal Adenocarcinoma, Qing Kay Li, Daniel Cui Zhou, Yize Li, Rita Jui-Hsien Lu, Li Ding, Et Al.

2020-Current year OA Pubs

BACKGROUND: The identification of differentially expressed tumor-associated proteins and genomic alterations driving neoplasia is critical in the development of clinical assays to detect cancers and forms the foundation for understanding cancer biology. One of the challenges in the analysis of pancreatic ductal adenocarcinoma (PDAC) is the low neoplastic cellularity and heterogeneous composition of bulk tumors. To enrich neoplastic cells from bulk tumor tissue, coring, and laser microdissection (LMD) sampling techniques have been employed. In this study, we assessed the protein and KRAS mutation changes associated with samples obtained by these enrichment techniques and evaluated the fraction of neoplastic cells in …

Beyond Functional Diversity: The Importance Of Trophic Position To Understanding Functional Processes In Community Evolution, Roxanne M. W. Banker, Ashley A. Dineen, Melanie G. Sorman, Carrie L. Tyler, Peter D. Roopnarine

Geoscience Faculty Research

Ecosystem structure—that is the species present, the functions they represent, and how those functions interact—is an important determinant of community stability. This in turn a􀀀ects how ecosystems respond to natural and anthropogenic crises, and whether species or the ecological functions that they represent are able to persist. Here we use fossil data from museum collections, literature, and the Paleobiology Database to reconstruct trophic networks of Tethyan paleocommunities fromthe Anisian and Carnian (Triassic), Bathonian (Jurassic), and Aptian (Cretaceous) stages, and compare these to a previously reconstructed trophic network from a modern Jamaican reef community. We generated model food webs consistent with …

Lessons Learned Xii, University Of Dayton

Materials from the University of Dayton Magazine Website

A continuing reflection on life acquired in and out of the classroom — from the classes of 1982 and 2001.

Enriched Dietary Saturated Fatty Acids Induce Trained Immunity Via Ceramide Production That Enhances Severity Of Endotoxemia And Clearance Of Infection, Amy L. Seufert, James W. Hickman, Ste K. Traxler, Rachael M. Peterson, Trent A. Waugh, Sydney L. Lashley, Natalia Shulzhenko, Ruth J. Napier, Brooke A. Napier

Biology Faculty Publications and Presentations

Trained immunity is an innate immune memory response that is induced by a primary inflammatory stimulus that sensitizes monocytes and macrophages to a secondary pathogenic challenge, reprogramming the host response to infection and inflammatory disease. Dietary fatty acids can act as inflammatory stimuli, but it is unknown if they can act as the primary stimuli to induce trained immunity. Here we find mice fed a diet enriched exclusively in saturated fatty acids (ketogenic diet; KD) confer a hyper-inflammatory response to systemic lipopolysaccharide (LPS) and increased mortality, independent of diet-induced microbiome and hyperglycemia. We find KD alters the composition of the …

Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites - Field Sampling And Investigation Plan (Fsp) Bres No. 8 – Belle Of Butte, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Montclarion, October 20, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Smart Drumlines Ineffective In Catching White Sharks In The High Energy Capes Region Of Western Australia: Acoustic Detections Confirm That Sharks Are Not Always Amenable To Capture, Stephen M. Taylor, Jason How, Michael J. Travers, Stephen J. Newman, Silas Mountford, Daniela Waltrick, Christopher E. Dowling, Ainslie M. Denham, Daniel J. Gaughan

Fisheries Research Articles

The management of human-shark interactions can benefit from the implementation of effective shark hazard mitigation measures. A Shark-Management-Alert-in-Real-Time (SMART) drumline trial in the Capes region of Western Australia was instigated after several serious incidents involving surfers and white sharks (Carcharodon carcharias). The project aimed to determine whether white sharks (target species), which were relocated after capture, remained offshore using satellite and acoustic tagging. Over a 27-month period, 352 fish were caught, 55% of which comprised tiger sharks (Galeocerdo cuvier). Ninety-one percent of animals were released alive in good condition. Only two white sharks were caught; both were relocated ≥ 1 …

The Cowl - V. 87 N. 5 - October 20, 2022

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 5 - October 20, 2022. 24 pages.

Best Practices Of Exceptional College Professors Who Program Relevance Into Online Distance Learning Courses: A Phenomenological Study, Keri Ann Palasz

Doctoral Dissertations and Projects

The purpose of this proposed transcendental phenomenological study was to describe specifically the experience of exceptional professors who convey relevance to students in online distance learning higher education courses. The theory that guided this study is Knowles’ Adult Learning Theory (ALT), as it clarifies the relationship between course design and delivery and the characteristics of adult learners. This study addressed four research questions posed to a sample of award-winning college professors who teach online distance learning courses in the American field of higher education to understand better what these professors do to convey relevance in a way that appeals to …

The Involvement Of Parents Of Students With Disabilities In Rural Early Head Start Programs: A Case Study, Cassandra Annette Justice

Doctoral Dissertations and Projects

The purpose of this qualitative collective case study was to describe parent participation for home-based educators and parents at an Early Head Start home-based program in rural Appalachia. Parental participation in the Early Head Start home-based program was generally defined as the active participation of children with disabilities’ parents in a home-based program guided by home-based educators through the implementation of early intervention services. Maslow’s hierarchy of needs guided this study, as it relates to both identifying barriers that may prevent parents from being involved and illuminates how Early Head Start educators help families meet growth and developmental needs. The …

Former College Athletes And Their Persistence In Medical School: A Phenomenological Study, Michael J. Woodson

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to understand the experiences of former college-athletes who persist in medical school. The theories that guided this study were the achievement goal theory by Nicholls and the self-determination theory by Deci and Ryan, as each theory relates to the motivation to succeed in academics, as well as athletic participation. Eleven participants were purposefully selected to address the question: How do former college student-athletes describe their experiences in relation to the attributes and characteristics that allowed them to persist in medical school? The sub-research questions investigated certain experiences that may have helped them …

Interactions Between Environmental Factors And Glutathione S-Transferase (Gst) Genes With Respect To Detectable Blood Aluminum Concentrations In Jamaican Children, Mohammad H Rahbar, Maureen Samms-Vaughan, Yuansong Zhao, Sepideh Saroukhani, Jan Bressler, Manouchehr Hessabi, Megan L Grove, Sydonnie Shakespeare-Pellington, Katherine A Loveland

Faculty, Staff and Student Publications

Aluminum (Al) is a metallic toxicant at high concentrations following natural or unnatural exposures. Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2−8 years) who participated as controls in an age- and sex-matched case−control study in Jamaica. We investigated additive and interactive associations among environmental factors and children’s genotypes for glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1), in relation to having a detectable blood aluminum concentration (BAlC) of >5.0 μg/L, using multivariable logistic regression models. Findings from interactive models revealed that the odds of having …

Early Life Exposure To Unpredictable Parental Sensory Signals Shapes Cognitive Development Across Three Species, Elyssia Poggi Davis, Kari Mccormack, Hina Arora, Desiree Sharpe, Annabel K. Short, Jocelyne Bachevalier, Laura M. Glynn, Curt A. Sandman, Hal S. Stern, Mar Sanchez, Tallie Z. Baram

Psychology Faculty Articles and Research

Exposure to early life adversity has long term consequences on cognitive function. Most research has focused on understanding components of early life adversities that contribute to later risk, including poverty, trauma, maltreatment, and neglect. Whereas these factors, in the aggregate, explain a significant proportion of emotional and cognitive problems, there are serious gaps in our ability to identify potential mechanisms by which early life adversities might promote vulnerability or resilience. Here we discuss early life exposure to unpredictable signals from the caretaker as an understudied type of adversity that is amenable to prevention and intervention. We employ a translational approach …

Exploration Of Theory And Method Of Studying Digital Governance Pattern, Tianyu Qiao, Youjun Li, Yue Zhao, Cheng Tan, Pingwen Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under the background of increasingly fierce competition in the field of digital governance around the world, it is very urgent and important to make scientific research and judgment on the pattern of digital governance. The article first explains how to understand the concept of digital governance and the pattern of digital governance. After reviewing the existing two perspectives of studies on the pattern of digital governance, this article provides a digital ecological perspective for studying the pattern of digital governance. It is found that the ecological perspective pays more attention to relevance, stratification, holism, aggregation, and dynamics. Thus, it extends …

Accelerate Construction Of New Pattern Of Ecological Protection In Northwest China, Qi Feng, Guangzu Bai, Zongxing Li, Bao Wang, Lijuan Chen, Penglong Wang, Tengfei Yu, Hongfei Meng, Wen Liu, Zhixiang Lu, Tingting Ning, Chengqi Zhang, Meng Zhu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Based on a profound understanding of the great significance of constructing an ecological protection pattern in Northwest China, this paper systematically summarizes the achievements, new problems and new trends of ecological protection in Northwest China, and accordingly, puts forward an overall spatial arrangement for the ecological protection under "two regions (watersheds)-six zones (core ecological function zones)-multiple points (key ecological points)". In addition, a key path to construct a new pattern of ecological protection in Northwest China is expounded in order to make more contributions to the acceleration of the harmonious co-existence between human and nature. The path is mainly based …

Screening Pathological Protein Specific Antibodies As Biomarker Discovery Tools For Neurodegenerative Disease, Yitong Li

USF Tampa Graduate Theses and Dissertations

With the increase in the average life span, the incidence of neurodegenerative diseases also increases, among which Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common types of neurological disorders. AD and PD share the same pathogenic mechanism that involves a class of proteins called beta-amyloid (Aβ), which, under the induction of some factors, changes from its natural monomeric state to the oligomers containing β-sheet, which is neurotoxic and thus leads to cell damage or apoptosis. This study focused on the selection of antibodies used as biomarkers for AD and PD. The selection of antibodies was based …

Lenalidomide Promotes The Development Of Tp53-Mutated Therapy-Related Myeloid Neoplasms, Adam S Sperling, Veronica A Guerra, James A Kennedy, Yuanqing Yan, Joanne I Hsu, Feng Wang, Andrew T Nguyen, Peter G Miller, Marie E Mcconkey, Vanessa A Quevedo Barrios, Ken Furudate, Linda Zhang, Rashmi Kanagal-Shamanna, Jianhua Zhang, Latasha Little, Curtis Gumbs, Naval Daver, Courtney D Dinardo, Tapan Kadia, Farhad Ravandi, Hagop Kantarjian, Guillermo Garcia-Manero, P Andrew Futreal, Benjamin L Ebert, Koichi Takahashi

Faculty, Staff and Student Publications

There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with driver gene mutations arise in the background of clonal hematopoiesis (CH) under the positive selective pressure of chemo- and radiation therapies. Uncovering the exposure relationships that provide selective advantage to specific CH mutations is critical to understanding the pathogenesis and etiology of t-MNs. In a systematic analysis of 416 patients with t-MN and detailed prior exposure history, we found that TP53 mutations were significantly associated with prior treatment with thalidomide analogs, specifically lenalidomide. We demonstrated experimentally that lenalidomide treatment provides a selective advantage to Trp53-mutant hematopoietic stem …

Disturbances In North American Boreal Forest And Arctic Tundra: Impacts, Interactions, And Responses, Adrianna C. Foster, Jonathan A. Wang, Gerald V. Frost, Scott J. Davidson, Elizabeth Hoy, Kevin W. Turner, Oliver Sonnentag, Howard Epstein, Logan T. Berner, Amanda H. Armstrong, Mary Kang, Brendan M. Rogers, Elizabeth Campbell, Kimberley R. Miner, Kathleen M. Orndahl, Laura L. Bourgeau-Chavez, David A. Lutz, Nancy French, Dong Chen, Jinyang Du, Tatiana A. Shestakova, Jacquelyn K. Shuman, Ken Tape, Anna Maria Virkkala, Christopher Potter, Scott Goetz

School of Geography, Earth and Environmental Sciences

Abstract Ecosystems in the North American Arctic-Boreal Zone (ABZ) experience a diverse set of disturbances associated with wildfire, permafrost dynamics, geomorphic processes, insect outbreaks and pathogens, extreme weather events, and human activity. Climate warming in the ABZ is occurring at over twice the rate of the global average, and as a result the extent, frequency, and severity of these disturbances are increasing rapidly. Disturbances in the ABZ span a wide gradient of spatiotemporal scales and have varying impacts on ecosystem properties and function. However, many ABZ disturbances are relatively understudied and have different sensitivities to climate and trajectories of recovery, …

The Student Movement Volume 107 Issue 5: Barkada Means Friendship: Andrews Embraces Fall And Filipino Culture, Sara Hamstra, Kavya Mohanram, Gloria Oh, Lauren Kim, Ysabelle Fernando, Ceiry Flores, Skylor Stark, Shania Watts, Kayla-Hope Bruno, T Bruggemann, Lexie Dunham, Charisse Lapuebla, Elizabeth Dovich, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

AIFA Celebrates Barkada, Interviewed by: Sara Hamstra

AU Student's Thoughts About Autumn, Interviewed by: Kavya Mohanram

Meet Joshua Deonarine, AUSA Financial VP, Interviewed by: Gloria Oh

Women in STEM Interview: Emily Rusnak, Interviewed by: Lauren Kim

ARTS & ENTERTAINMENT

Box Factory for the Arts, Ysabelle Fernando

Creatives on Campus: Filipino American History Month Edition, Ceiry Flores

The Old Warhorse: Wind Symphony's Saturday Concert, Skylor Stark

NEWS

Edsel Adap's Story: How AFIA Came to Be, Sara Hamstra

Learning Traditional Filipino Dance with AFIA, Ceiry Flores

Andrews Opens New Career Center!, Gloria Oh

IDEAS

Be Your Own Bastion for Fashion, Shania …

Control Of Ribosomal Rna Synthesis By Hematopoietic Transcription Factors, Charles Antony, Subin S George, Justin Blum, Patrick Somers, Chelsea L Thorsheim, Dexter J Wu-Corts, Yuxi Ai, Long Gao, Kaosheng Lv, Michel G Tremblay, Tom Moss, Kai Tan, Jeremy E Wilusz, Austen R D Ganley, Maxim Pimkin, Vikram R Paralkar

Faculty, Staff and Students Publications

Ribosomal RNAs (rRNAs) are the most abundant cellular RNAs, and their synthesis from rDNA repeats by RNA polymerase I accounts for the bulk of all transcription. Despite substantial variation in rRNA transcription rates across cell types, little is known about cell-type-specific factors that bind rDNA and regulate rRNA transcription to meet tissue-specific needs. Using hematopoiesis as a model system, we mapped about 2,200 ChIP-seq datasets for 250 transcription factors (TFs) and chromatin proteins to human and mouse rDNA and identified robust binding of multiple TF families to canonical TF motifs on rDNA. Using a 47S-FISH-Flow assay developed for nascent rRNA …

Objective Assessment Of Upper-Extremity Motor Functions In Spinocerebellar Ataxia Using Wearable Sensors, Reza Mohammadi-Ghazi, Hung Nguyen, Ram Kinker Mishra, Ana Enriquez, Bijan Najafi, Christopher D Stephen, Anoopum S Gupta, Jeremy D Schmahmann, Ashkan Vaziri

Center on Aging Staff Publications

The study presents a novel approach to objectively assessing the upper-extremity motor symptoms in spinocerebellar ataxia (SCA) using data collected via a wearable sensor worn on the patient’s wrist during upper-extremity tasks associated with the Assessment and Rating of Ataxia (SARA). First, we developed an algorithm for detecting/extracting the cycles of the finger-to-nose test (FNT). We extracted multiple features from the detected cycles and identified features and parameters correlated with the SARA scores. Additionally, we developed models to predict the severity of symptoms based on the FNT. The proposed technique was validated on a dataset comprising the seventeen (n …

Integrated Host-Microbe Plasma Metagenomics For Sepsis Diagnosis In A Prospective Cohort Of Critically Ill Adults, Katrina L Kalantar, Pratik Sinha, Et Al.

2020-Current year OA Pubs

We carried out integrated host and pathogen metagenomic RNA and DNA next generation sequencing (mNGS) of whole blood (n = 221) and plasma (n = 138) from critically ill patients following hospital admission. We assigned patients into sepsis groups on the basis of clinical and microbiological criteria. From whole-blood gene expression data, we distinguished patients with sepsis from patients with non-infectious systemic inflammatory conditions using a trained bagged support vector machine (bSVM) classifier (area under the receiver operating characteristic curve (AUC) = 0.81 in the training set; AUC = 0.82 in a held-out validation set). Plasma RNA also yielded a …

Montana Kaimin, October 20, 2022, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Postoperative Hypocalcemia Following Non-Cardiac Surgical Procedures In Children With 22q11.2 Deletion Syndrome., Jill M. Arganbright, Meghan Tracy, Matthew M. Feldt, Srivats Narayanan, Ashna Mahadev, Janelle R. Noel-Macdonnell Phd

Manuscripts, Articles, Book Chapters and Other Papers

The guidelines for management of children with 22q11.2 deletion syndrome (22q11DS) highlight the risk for developing hypocalcemia after surgery and recommend monitoring calcium perioperatively. Despite this guidance, little has been published on postoperative hypocalcemia and 22q11DS. Our goals were to evaluate the frequency of perioperative calcium monitoring and examine how often postoperative hypocalcemia was identified. This is a retrospective chart review of patients in our 22q Center's repository. Inclusion criteria were a diagnosis of 22q11DS and a history of a non-cardiac surgical procedure. Data collected included all non-cardiac surgeries and perioperative calcium labs. In total, 68 patients were included and …

The Wages Of Crying Life: What States Must Do To Protect Children After The Fall Of Roe, Leah A. Plunkett, Michael S. Lewis

Pepperdine Law Review

In the post-Roe world, can a state rationally claim that the value of human life justifies the imposition of abortion bans but does not demand that a state protect the vulnerable young who are “born human beings”—commonly called “minors” or “children”—and are entitled to protection under a state’s laws? This essay advances the claim that it cannot. This essay asks that those who say they are “Pro-life” in politics and law demonstrate that they protect vulnerable life beyond the abortion context, and that they do so in the most minimal fashion: through a demonstrated commitment to protecting the basic welfare …

Tolkien, Race, And Racism In Middle-Earth By Robert Stuart, Robert T. Tally Jr.

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

n/a

“What Happened To Battles Are Ugly Affairs?”: Fighting Girls In The Films The Chronicles Of Narnia, Chapters 1, 2 And 3, Anne-Frédérique Mochel-Caballero

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Although C.S. Lewis’s Chronicles of Narnia (1950-1956) are still hugely popular today, some critics have accused the books of representing masculinity and femininity in an outmoded way. The three Walden Media films, The Lion, the Witch and the Wardrobe (2005), Prince Caspian (2008) and The Voyage of the Dawn Treader (2010), appear to adopt a more contemporary perspective, especially as far as the representation of fighting girls is concerned. While Lewis seemed slightly reluctant to show women playing an active role on the battlefield, Andrew Adamson, who directed the first two films, lets Susan, the female protagonist, fight alongside the …

Tellers Of Dark Fairy Tales: Common Themes In The Works Of C.S. Lewis And Terence Fisher, Gabriel C. Salter

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

This article explores connections between C.S. Lewis and filmmaker Terence Fisher, notably how their works explore themes like the charm of evil, white magic’s dubious nature, and myth hinting at divine truths. By viewing these themes, Fisher and Lewis’s common views on fairy tales, and how feedback informed their work, scholars discover nuance in the perceived “Inklings versus secular British culture” dichotomy.

Echoing Ecopoetics: Fantasy Literature's Background Sounds, Catherine Olver

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Despite David Abram’s fear that reading disrupts people’s “attunement to environing nature,” fantasy literature can vibrantly convey how to hear our environments as it describes characters attuning their ears to particular places. Garth Nix’s Old Kingdom series (1995-2021) and Patrick Ness’s Chaos Walking trilogy (2008-10) develop an echoing ecopoetics of place through both world-building and style. Their fantasy worlds emphasize that characters must relearn to listen in unfamiliar environments: adjusting their expectations and interpretations of background sounds, recognising significant silences, adapting to new ways of communicating, and seeking meaning in nonhuman sounds rather than dismissing them as noise. Their stylistic …

History In The Margins: Epigraphs And Negative Space In Robin Hobb’S Assassin’S Apprentice, Matthew Oliver

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Robin Hobb’s Assassin’s Apprentice demonstrates a significant effect of epic fantasy’s conventions for creating the history of a fictional world. By prefacing each chapter with an epigraph from an official in-world historical text before giving a first-person personal narrative, the novel blurs the boundaries between text and paratext, public and private, official history and personal myth-making. This structure raises questions about what is central and marginal in history, suggesting the extent to which historical narrative is constructed in the imagination by taking the facts surrounding a central event from which the historian is absent—a process much like negative space drawing …