Digital Commons Network^™

Adherence To Best Practices For Stated Preference Valuation Within The U.S. Marine Ecosystem Services Literature, Daniel K. Lew, Leif E. Anderson, Douglas W. Lipton, Tammy B. Murphy, Kristy Wallmo

Journal of Ocean and Coastal Economics

Non-market economic values derived from stated preference (SP) methods are often of interest for policy analysis and evaluation, program design, green accounting, and damage assessments and are increasingly in demand with adoption of ecosystem-based management approaches that emphasize accounting for ecosystem services and their values. A recent guidance prescribes a set of twenty-three best practices guidelines (BPGs) to follow when conducting a SP study to ensure the validity of the results and maximize its ability to provide reliable economic value information. In this article, we evaluate adherence to these guidelines within the U.S. SP marine ecosystem service valuation literature. Our …

A Rare Presentation Of Fulminant Toxic Shock Syndrome In A Healthy 10-Year-Old Male Patient, Albert Sabirov, Michael Caplan

Advances in Clinical Medical Research and Healthcare Delivery

Staphylococcal toxic shock syndrome (STSS) is characterized by acute, progressive illness with fever, rapid-onset hypotension, and multisystem organ failure. The clinical course of STSS is attributable to host response to exotoxins with superantigenic properties. Fulminant staphylococcal infection is often associated with a deep focus of infection. In this report, we present a 10-year-old boy with multisystem organ failure as a result of STSS, a rare fatal complication following soft tissue injury. The rapid and fulminant progression of the disease in our patient precluded early timely diagnosis of STSS that may have allowed for the initiation of life-saving supportive intervention. Furthermore, …

Evaluation Of Antibody Response To Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Vaccination In Patients With Lymphoid And Solid Organ Malignancies, Mukul Singal, Sanjana Kalvehalli Kashinath, S. Shahzad Mustafa, Edward Walsh, Karthik Vadamalai, Saad Jamshed

Advances in Clinical Medical Research and Healthcare Delivery

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. There is emerging evidence regarding suboptimal response to vaccination against COVID-19 in patients with hematologic and solid organ malignancies.

We conducted a single-center prospective study assessing seroconversion in response to vaccination against COVID-19 in 53 patients with chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), and solid organ malignancies.

A quantitative immunoassay of IgG antibodies to SARS-CoV-2 Spike (S) protein was measured prior to vaccination and at 2 weeks after completion of two-dose vaccination series. A fourfold increase in antibody titers was considered positive …

Reliability, Validity, And Exploratory Factor Analyses Of Gentrification Health Research Measures, Christopher Williams, Nathaniel Woodard, Charlene Chao-Li Kuo

Advances in Clinical Medical Research and Healthcare Delivery

Background

Gentrification is a type of neighborhood change (NC) that causes demographic shifts and improvement in the built environment. Adverse health outcomes associated with NC have not been consistently established in the literature. Yet, major methodological barriers define this field of study including lack of tailored and culturally relevant measures. This aim of this study was to assess the psychometric properties of novel and adapted NC measures that sought to improve appropriateness for all literacy levels, to enhance survey efficiency, and to assess features of the built environment.

Methods

We conducted a cross-sectional study in a highly gentrifying neighborhood in …

Overqualified And Underrepresented: Gender Inequality In Pharmaceutical Patent Law, S. Sean Tu, Paul R. Gugliuzza, Amy Semet

Journal Articles

Pharmaceutical patents represent some of the most valuable intellectual property assets in the world: they can be worth billions of dollars if courts uphold their validity and find them infringed. But, if invalidated, generic drug manufacturers can get to market earlier, generating billions of dollars of revenue for themselves and creating enormous savings for consumers. Accordingly, drug patents are the product of careful, high-cost prosecution and are associated with high-stakes, bet-the-company litigation. But women lawyers are noticeably absent from pharmaceutical patent practice. This article reports an original empirical study finding that women comprise only one-third of the top pharmaceutical patent …

Stabilized Core Gene And Pathway Election Uncovers Pan-Cancer Shared Pathways And A Cancer-Specific Driver, Pathum Kossinna, Weijia Cai, Xuewen Lu, Carrie S Shemanko, Qingrun Zhang

Department of Cancer Biology Faculty Papers

Approaches systematically characterizing interactions via transcriptomic data usually follow two systems: (i) coexpression network analyses focusing on correlations between genes and (ii) linear regressions (usually regularized) to select multiple genes jointly. Both suffer from the problem of stability: A slight change of parameterization or dataset could lead to marked alterations of outcomes. Here, we propose Stabilized COre gene and Pathway Election (SCOPE), a tool integrating bootstrapped least absolute shrinkage and selection operator and coexpression analysis, leading to robust outcomes insensitive to variations in data. By applying SCOPE to six cancer expression datasets (BRCA, COAD, KIRC, LUAD, PRAD, and THCA) in …

Migrant Visits Over Time: Ethnographic Returning And The Technological Turn, Loretta Baldassar

Research outputs 2022 to 2026

This paper reflects on four decades of research (via ethnographic returning) to explore the social transformations in travel and communication technologies that have impacted the lived experiences, and consequently the theoretical conceptualization, of migrant visits. A comparison of migration waves between Italy and Australia reveals both continuities in visiting experience as deeply relational practices that facilitate a mutuality of being, but also transformations brought about by the technological turn. Visits take on different meanings depending on individual/ family life stage, generation, and community and national histories. The capacity for both physical and virtual copresence must be understood as coconstitutive, requiring …

Inequality Among The Disadvantaged? Racial/Ethnic Disparities In Earnings Among Young Men And Women Without A College Education, Byeongdon Oh, Daniel Mackin Freeman, Dara Shifrer

Sociology Faculty Publications and Presentations

Despite the rapid expansion of higher education, many young adults still enter the labor market without a college education. However, little research has focused on racial/ethnic earnings disadvantages faced by non-college-educated youth. We analyze the restricted-use data from the High School Longitudinal Study of 2009 to examine racial/ethnic earnings disparities among non-college-educated young men and women in their early 20s as of 2016, accounting for differences in premarket factors and occupation with an extensive set of controls. Results suggest striking earnings disadvantages for Black men relative to white, Latinx, and Asian men. Compared to white men, Latinx and Asian men …

Nikki S. Lee’S Self-Stereotyping And Refiguring Cultural Stereotypes, Somi Lee

Theses and Dissertations

This thesis examines a Korean Conceptual photographer, Nikki S. Lee’s performative photographs and film in the series of Projects (1998-2001) and Parts (2002-2005). Through a theoretical analysis of her self-representation in disguise, my research explores established Western stereotypes as well as the artist’s fluid identity in relation to other cultures.

Effect Of Diabetes-Associated Mutations In Kir 6.2/Sur1 On Katp Channel Activities, Yunpeng Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

Maturity Onset Diabetes of the Young (MODY) is a type of diabetes, distinct from either type I or type II, that happens before age 25 (MedlinePlus, 2022). Unlike the other two more common forms of diabetes, MODY is classified as a series of monogenetic disorders (American Diabetes Association Professional Practice Committee, 2021), caused by autosomal mutations. MODY is typically characterized by insufficient secretion of insulin, a similar symptom to type I diabetes, classified into 14 different types based on mutations found on different genes. Among them, subtypes 12 and 13, also called neonatal diabetes mellitus (NDM), are caused by gain-of-function …

The Role Of Dha In The Impact Of Trem2 On Microglia Activation And Alzheimer’S Disease, Michael A. Palmieri Iii

Seton Hall University Dissertations and Theses (ETDs)

Alzheimer’s disease (AD) is a neurological disease that is associated with microglia activation. An important receptor involved in microglia activation is Triggering receptor expressed on myeloid cells 2 (TREM2). Recent studies suggest that docosahexaenoic acid (DHA) could reduce the neuroinflammation that is associated with microglia activation. We hypothesized that when DHA concentration was increased, TREM2 expression would decrease, microglia activity would be inhibited, and a resulting decrease in neuroinflammation would be observed. We examined peer-reviewed journal articles from 2017-2022 that investigated the relationship between TREM2 activation and severity of AD symptoms, the protective properties of DHA against AD, and the …

Extracellular Vesicle Characteristics And Micro Rna Content In Cerebral Palsy And Typically Developed Individuals At Rest And In Response To Aerobic Exercise., Ivan Jose Vechetti Jr, Jessica Norrbom, Björn Alkner, Emma Hjalmarsson, Alexandra Palmcrantz, Eva Pontén, Jessica Pingel, Ferdinand Von Walden, Rodrigo Fernandez-Gonzalo

Department of Nutrition and Health Sciences: Faculty Publications

In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA cargo of EVs. Nine adult individuals with CP performed a single exercise bout consisting of 45 min of Frame Running, and TD participants completed either 45 min of cycling (n = 10; TD EX) or were enrolled as controls with no exercise (n = 10; TD CON). Blood was drawn before and 30 min after exercise and analyzed for EV concentration, size, and microRNA …

Development Of Tool To Measure Mechanics Of Cylindrical Soft Tissue Samples, Perry Brody

Mechanical Engineering and Materials Science Independent Study

The objective of this study was to develop a tool to measure the mechanics of cylindrical soft tissue samples, specifically applied to the mouse uterus. Specialized equipment is required to perform such testing at the desired scale and sensitivity. An adjustable fixture was developed to mount mouse uterine ring samples with a method that allowed us to perform tensile testing using the ElectroForce 3200 Mechanical Testing System. The geometric parameters of the sample were determined by front and side-angled cameras throughout the test. Using the collected force-displacement data from the ElectroForce and the video recordings, the mechanical response of tissue …

Activation Of Basal Forebrain-To-Lateral Habenula Circuitry Drives Reflexive Aversion And Suppresses Feeding Behavior, Jessica L Swanson, Joshua Ortiz-Guzman, Snigdha Srivastava, Pey-Shyuan Chin, Sean W Dooling, Elizabeth Hanson Moss, Mikhail Y Kochukov, Patrick J Hunt, Jay M Patel, Brandon T Pekarek, Qingchun Tong, Benjamin R Arenkiel

Faculty, Staff and Student Publications

Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in homeostatic feeding. However, many of the neural circuits that drive more complex, non-homeostatic feeding that integrate valence and sensory cues (such as taste and smell) remain unknown. Here, we describe a basal forebrain (BF)-to-lateral habenula (LHb) circuit that directly modulates non-homeostatic feeding behavior. Using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the BF that project to the LHb, which responds to diverse sensory cues, including aversive and food-related …

Spaci: Deciphering Spatial Cellular Communications Through Adaptive Graph Model, Ziyang Tang, Tonglin Zhang, Baijian Yang Ph.D., Jing Su, Qianqian Song

Publications

Cell-cell communications are vital for biological signalling and play important roles in complex diseases. Recent advances in single-cell spatial transcriptomics (SCST) technologies allow examining the spatial cell communication landscapes and hold the promise for disentangling the complex ligand-receptor (L-R) interactions across cells. However, due to frequent dropout events and noisy signals in SCST data, it is challenging and lack of effective and tailored methods to accurately infer cellular communications. Herein, to decipher the cell-to-cell communications from SCST profiles, we propose a novel adaptive graph model with attention mechanisms named spaCI. spaCI incorporates both spatial locations and gene expression profiles of …

Knowing The Biosphere: Documentation, Specimens, Archives, And Names Reveal Environmental Change And Emerging Pathogens, Eric P. Hoberg, Valeria Trivellone, Joseph A. Cook, Jonathan L. Dunnum, Walter A. Boeger, Daniel R. Brooks, Salvatore J. Agosta, Jocelyn P. Colella

MANTER: Journal of Parasite Biodiversity

One Health programs and trajectories are now the apparent standard for exploring the occurrence and distribution of emerging pathogens and disease. By definition, One Health has been characterized as a broadly inclusive, collaborative, and transdisciplinary approach with connectivity across local to global scales, which integrates the medical and veterinary community to recognize health outcomes emerging at the environmental nexus for people, animals, plants, and their shared landscapes. One Health has been an incomplete model, conceptually and operationally, focused on reactive and response-based foundations, to limit the impact of emerging pathogens and emerging infectious diseases and, as such, lacks a powerful …

Impact Of Covid-19 On A Worksite Weight Loss Program For Employees With Overweight And Obesity, Che Young Lee, Michael C Robertson, Kendahl Servino, Thuan Le, Margaret Raber, Katherine Oestman, Karen M Basen-Engquist

Faculty, Staff and Students Publications

OBJECTIVE: The COVID-19 pandemic has been shown to be negatively associated with physical activity engagement, adherence to healthy diet, and weight management among people with obesity. The current study examined COVID-19-related changes in weight, physical activity (PA), and diet among employees with obesity or overweight who participated in Vibrant Lives (VL), a worksite weight loss program.

METHODS: School district employees participated in the 6-month VL weight loss program and were categorized into non-COVID-era participants and COVID-era participants. Participants completed questionnaires about PA and dietary intake at baseline and follow-up. COVID-era participants reported the effects of pandemic on their behaviors. Changes …

Implementation Of The Family Help Protocol: A Feasibility Project For A West Texas Icu, Rebecca Mcclay

Dissertations

The purpose of this project was to determine if there is sufficient bedside ICU nurse buy-in to the Family HELP protocol to make implementation feasible at one county hospital in West Texas.

Machine Learning And Protein Allostery, Sian Xiao, Gennady M. Verkhivker, Peng Tao

Mathematics, Physics, and Computer Science Faculty Articles and Research

The fundamental biological importance and complexity of allosterically regulated proteins stem from their central role in signal transduction and cellular processes. Recently, machine-learning approaches have been developed and actively deployed to facilitate theoretical and experimental studies of protein dynamics and allosteric mechanisms. In this review, we survey recent developments in applications of machine-learning methods for studies of allosteric mechanisms, prediction of allosteric effects and allostery-related physicochemical properties, and allosteric protein engineering. We also review the applications of machine-learning strategies for characterization of allosteric mechanisms and drug design targeting SARS-CoV-2. Continuous development and task-specific adaptation of machine-learning methods for protein allosteric …

Four Students Receive Grants For Ideas Through Titan New Venture Challenge, Mj Soria

News and Events (Discontinued Series)

No abstract provided.

Molecular Markers In Maternal Blood Exosomes Allow Early Detection Of Fetal Alcohol Spectrum Disorders, Nune Darbinian, Armine Darbinyan, John Sinard, Gabriel Tatevosian, Nana Merabova, Faith D'Amico, Tarek Khader, Ahsun Bajwa, Diana Martirosyan, Alina K Gawlinski, Richa Pursnani, Huaqing Zhao, Shohreh Amini, Mary Morrison, Laura Goetzl, Michael E Selzer

Faculty, Staff and Student Publications

Prenatal alcohol exposure can cause developmental abnormalities (fetal alcohol spectrum disorders; FASD), including small eyes, face and brain, and neurobehavioral deficits. These cannot be detected early in pregnancy with available imaging techniques. Early diagnosis could facilitate development of therapeutic interventions. Banked human fetal brains and eyes at 9−22 weeks’ gestation were paired with maternal blood samples, analyzed for morphometry, protein, and RNA expression, and apoptotic signaling. Alcohol (EtOH)-exposed (maternal self-report) fetuses were compared with unexposed controls matched for fetal age, sex, and maternal race. Fetal brain-derived exosomes (FB-E) were isolated from maternal blood and analyzed for protein, RNA, and apoptotic …

Systemic Delivery Of Divalent Europium From Ligand Screening With Implications To Direct Imaging Of Hypoxia, Md Mamunur Rashid, Brooke A Corbin, Pavan Jella, Caitlyn J Ortiz, Md Abul Hassan Samee, Robia G Pautler, Matthew J Allen

Faculty, Staff and Students Publications

Hypoxia is a hallmark of many diseases, including cancer, arthritis, heart and kidney diseases, and diabetes, and it is often associated with disease aggressiveness and poor prognosis. Consequently, there is a critical need for imaging hypoxia in a noninvasive and direct way to diagnose, stage, and monitor the treatment and development of new therapies for these diseases. Eu-containing contrast agents for magnetic resonance imaging have demonstrated potential for in vivo imaging of hypoxia via changes in metal oxidation state from +2 to +3, but rapid oxidation in blood limits EuII-containing complexes to only studies compatible with direct injection to sites. …

Concurrent Mutations In Sf3b1 And Phf6 In Myeloid Neoplasms, Zhuang Zuo, L Jeffrey Medeiros, Sofia Garces, Mark J Routbort, Chi Young Ok, Sanam Loghavi, Rashmi Kanagal-Shamanna, Fatima Zahra Jelloul, Guillermo Garcia-Manero, Kelly S Chien, Keyur P Patel, Rajyalakshmi Luthra, C Cameron Yin

Faculty, Staff and Student Publications

It has been reported that gene mutations in SF3B1 and PHF6 are mutually exclusive. However, this observation has never been rigorously assessed. We report the clinicopathologic and molecular genetic features of 21 cases of myeloid neoplasms with double mutations in SF3B1 and PHF6, including 9 (43%) with myelodysplastic syndrome, 5 (24%) with acute myeloid leukemia, 4 (19%) with myeloproliferative neoplasms, and 3 (14%) with myelodysplastic/myeloproliferative neoplasms. Multilineage dysplasia with ring sideroblasts, increased blasts, and myelofibrosis are common morphologic findings. All cases but one had diploid or non-complex karyotypes. SF3B1 mutations were detected in the first analysis of all the …

Assessing The Influence Of Behavioural Parameterisation On The Dispersal Of Larvae In Marine Systems, M. K. James, J. A. Polton, C. G. Mayorga-Adame, K. L. Howell, A. M. Knights

School of Biological and Marine Sciences

Predicting dispersal and quantifying ecological connectivity are increasingly referenced as fundamental to understanding how biodiversity is structured across space and time. Dispersal models can provide insight, but their predictions are influenced by our capacity to simulate the biology and physics known to influence dispersal. In a marine context, vertical swimming behaviour is considered important in influencing the spatial organisation of species across seascapes, but the mechanisms underpinning these movements remain unresolved, making it unclear how best to incorporate behaviour within models. Here, using a 3-D hydrodynamic model coupled with a Lagrangian particle tracker, we show how different modelled larval behaviours, …

Can A Combined Agriculture And Nutrition Behaviour Change Intervention Improve Women’S Empowerment? A Mixed Methods Feasibility Study In Rural Bangladesh, Elizabeth K. Kirkwood, Michael J. Dibley, Wajiha Khatun, Gulshan Ara, Mansura Khanam, Anowarul Bokshi, Mu Li, Neeloy Ashraful Alam

The Qualitative Report

Many agricultural and home gardening interventions aim to improve the nutritional status of women and children in low- and middle-income countries by focusing on women as the recipients of the intervention and make assumptions that women will be empowered as a result. This paper examines the potential impact of an intervention study that combined home garden training and support, and nutrition behaviour change communication, with a social safety net payment, on women’s empowerment in rural Bangladesh. We assessed the implementation of this study in terms of feasibility, acceptability, and practical application. Twenty in-depth interviews were conducted with randomly selected women …

The Association Between Adverse Childhood Experiences, Self-Silencing Behaviours And Symptoms In Women With Fibromyalgia., Alison M. Bacon, Leah White

School of Psychology

Poor adult health has consistently been associated with Adverse Childhood Experiences (ACEs). The process is not fully understood but is likely to involve a complex interaction of biological and psychosocial factors. Early life stress can affect the developing brain resulting in long-term hyper-responses to stress and raised inflammatory biomarkers. Women with fibromyalgia syndrome (FMS) frequently report ACEs and also self-sacrificial behaviours whereby they repress their own needs and emotions to preserve personal relationships. This behavioural profile (termed self-silencing) may develop following ACEs but has not previously been considered in the context of FMS. This study examined whether self-silencing mediates the …

Antibodies Targeting The Neuraminidase Active Site Inhibit Influenza H3n2 Viruses With An S245n Glycosylation Site, Daniel Stadlbauer, Ali H Ellebedy, Et Al.

2020-Current year OA Pubs

Contemporary influenza A H3N2 viruses circulating since 2016 have acquired a glycosylation site in the neuraminidase in close proximity to the enzymatic active site. Here, we investigate if this S245N glycosylation site, as a result of antigenic evolution, can impact binding and function of human monoclonal antibodies that target the conserved active site. While we find that a reduction in the inhibitory ability of neuraminidase active site binders is measurable, this class of broadly reactive monoclonal antibodies maintains protective efficacy in vivo.

Expanded Proteomic Survey Of The Human Parasite Leishmania Major Focusing On Changes In Null Mutants Of The Golgi Gdp-Mannose/Fucose/Arabinopyranose Transporter, Gloria Polanco, Nichollas E Scott, Lon F Lye, Stephen M Beverley

2020-Current year OA Pubs

The trypanosomatid protozoan parasite

Impact Of Cd4 T Cells On Intratumoral Cd8 T-Cell Exhaustion And Responsiveness To Pd-1 Blockade Therapy In Mouse Brain Tumors, Saad M. Khan, Rupen Desai, Andrew Coxon, Alexandra Livingstone, Gavin P Dunn, Allegra Petti, Tanner M Johanns

2020-Current year OA Pubs

BACKGROUND: Glioblastoma is a fatal disease despite aggressive multimodal therapy. PD-1 blockade, a therapy that reinvigorates hypofunctional exhausted CD8 T cells (T

METHODS: Single-cell RNA sequencing was performed on flow sorted tumor-infiltrating lymphocytes from female C57/BL6 mice implanted with each model, with and without PD-1 blockade therapy. CD8

RESULTS: The CD8 T-cell compartment of the models is composed of heterogenous CD8 T

CONCLUSIONS: Here, we describe that dysfunctional CD4 T cells are associated with terminal CD8 T-cell exhaustion, suggesting CD4 T cells impact PD-1 blockade efficacy by controlling the severity of exhaustion. Given that CD4 lymphopenia is frequently observed in …

A Genome-Wide Association Study Of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants, Harold Bae, Ping An, Mary Feitosa, Et Al.

2020-Current year OA Pubs

We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls. The analysis identified a locus in CDKN2B-AS1 (rs6475609,