Digital Commons Network^™

2021-2022, Full Issue

Undergraduate Psychology Research Methods Journal

No abstract provided.

Advancing Clinical And Translational Research In Germ Cell Tumours (Gct): Recommendations From The Malignant Germ Cell International Consortium., Adriana Fonseca, João Lobo, Florette K Hazard, Joanna J Gell, Peter K Nicholls, Robert S Weiss, Lindsay Klosterkemper, Samuel L Volchenboum, James C Nicholson, A Lindsay Frazier, James F Amatruda, Aditya Bagrodia, Michelle Lockley, Matthew J Murray

Faculty Research 2022

Germ cell tumours (GCTs) are a heterogeneous group of rare neoplasms that present in different anatomical sites and across a wide spectrum of patient ages from birth through to adulthood. Once these strata are applied, cohort numbers become modest, hindering inferences regarding management and therapeutic advances. Moreover, patients with GCTs are treated by different medical professionals including paediatric oncologists, neuro-oncologists, medical oncologists, neurosurgeons, gynaecological oncologists, surgeons, and urologists. Silos of care have thus formed, further hampering knowledge dissemination between specialists. Dedicated biobank specimen collection is therefore critical to foster continuous growth in our understanding of similarities and differences by age, …

Clinical Impact Of Ceftriaxone Resistance In Escherichia Coli Bloodstream Infections: A Multicenter Prospective Cohort Study, Pranita D. Tamma, Lauren Komarow, Lizhao Ge, Julia Garcia-Diaz, Erica S. Herc, Yohei Doi, Cesar A. Arias, Owen Albin, Elie Saade, Loren G. Miller, Jesse T. Jacob, Michael J. Satlin, Martin Krsak, W. Charles Huskins, Sorabh Dhar, Samuel A. Shelburne, Carol Hill, Keri R. Baum, Minal Bhojani, Kerryl E. Greenwood-Quaintance, Suzannah M. Schmidt-Malan, Robin Patel, Scott R. Evans, Henry F. Chambers, Vance G. Fowler, David Van Duin

Infectious Diseases Articles

BACKGROUND: Ceftriaxone-resistant (CRO-R) Escherichia coli bloodstream infections (BSIs) are common.

METHODS: This is a prospective cohort of patients with E coli BSI at 14 United States hospitals between November 2020 and April 2021. For each patient with a CRO-R E coli BSI enrolled, the next consecutive patient with a ceftriaxone-susceptible (CRO-S) E coli BSI was included. Primary outcome was desirability of outcome ranking (DOOR) at day 30, with 50% probability of worse outcomes in the CRO-R group as the null hypothesis. Inverse probability weighting (IPW) was used to reduce confounding.

RESULTS: Notable differences between patients infected with CRO-R and CRO-S …

Moderated Mediation Research - The Impact Of Organizational Change Capability On Organizational Engagement - The Role Of Organizational Trust And Leadership Style, Jin Liang

Fordham Dissertations and Theses

With the rapid development of emerging technologies, representative by *ABCDMIX, disruption brought by the innovation is rampant across industries: competition boundaries have become blurred, cross-border penetration between industries is ubiquitous, and many established enterprises’ business models have been shaken. Despite the adaptive adjustments made by organizations, most corporations are still struggling to get out of this predicament.

The failure of a mature enterprise’s adjustments is often attributed to the belief that the corporation's strategy was wrongly formulated, or that the strategy’s positive direction was undermined due to the rigid nature of the organization. It is important to consider what exactly …

Association Of Pediatric Buccal Epigenetic Age Acceleration With Adverse Neonatal Brain Growth And Neurodevelopmental Outcomes Among Children Born Very Preterm With A Neonatal Infection., Noha Gomaa, Chaini Konwar, Nicole Gladish, Stephanie H Au-Young, Ting Guo, Min Sheng, Sarah M Merrill, Edmond Kelly, Vann Chau, Helen M Branson, Linh G Ly, Emma G Duerden, Ruth E Grunau, Michael S Kobor, Steven P Miller

Department of Medicine Publications

IMPORTANCE: Very preterm neonates (24-32 weeks' gestation) remain at a higher risk of morbidity and neurodevelopmental adversity throughout their lifespan. Because the extent of prematurity alone does not fully explain the risk of adverse neonatal brain growth or neurodevelopmental outcomes, there is a need for neonatal biomarkers to help estimate these risks in this population.

OBJECTIVES: To characterize the pediatric buccal epigenetic (PedBE) clock-a recently developed tool to measure biological aging-among very preterm neonates and to assess its association with the extent of prematurity, neonatal comorbidities, neonatal brain growth, and neurodevelopmental outcomes at 18 months of age.

DESIGN, SETTING, AND …

The Impact Of Biofilms And Dissolved Organic Matter On The Transport Of Nanoparticles In Field-Scale Streams, Junyeol Kim, Kevin R. Roche, Diogo Bolster, Kyle Doudrick

Civil Engineering Faculty Publications and Presentations

The fate and transport of nanoparticles (NPs) in streams is critical for understanding their overall environmental impact. Using a unique field-scale stream at the Notre Dame-Linked Experimental Ecosystem Facility, we investigated the impact of biofilms and the presence of dissolved organic matter (DOM) on the transport of titanium dioxide (TiO₂) NPs. Experimental breakthrough curves were analyzed using temporal moments and fit using a mobile-immobile model. The presence of biofilms in the stream severely reduced the transport of the TiO₂ NPs, but this was mitigated by the presence of DOM. Under minimal biofilm conditions, the presence of DOM …

Remedying The Immortal: The Doctrine Of Accession And Patented Human Cell Lines, Julia E. Fissore-O'Leary

Notre Dame Law Review

Importantly, though this Note employs Henrietta Lacks as the illustrative, paradigmatic case for the theory of accession it proposes, accession can be, and should be, broadly construed to apply to all like-situated patients. Part I of this Note briefly explains the timeless human-body-as-property debate. Next, Part II addresses the concept of accession—its theoretical underpinnings, definitions, and amenability to this and other lawsuits. Part III applies accession to HeLa and develops a methodology for calculating damages in this unique setting. This Note does not pretend to present a perfectly wrought formula. Instead, it offers several possibilities for determining compensation. Finally, …

The Impact Of Cpsf6 On The Innate Immune Response To Hiv Infection, Kenith Taukolo '23

Student Publications & Research

With no current vaccine for Human Immunodeficiency Virus ( it is crucial to study what factors influence how HIV infects host cells to develop new strategies and therapies to combat this pandemic Cleavage and polyadenylation specificity factor 6 (CPSF 6 is an HIV host factor known to influence HIV infectivity and trafficking early in the infection CPSF 6 has been implicated in supporting the innate immune response but its impact in the context of HIV is unclear We hypothesize that the overexpression of CPSF 6 will increase the antiviral response and decrease HIV infection in T cells To test the …

Thermal Damage Estimate Artifact Following Antecedent Biopsy: A Case Report, Salma M. Bakr, Pranish A. Kantak, Med Jimson D. Jimenez, Hailey C. Budnick, Jeffrey Raskin

Neurosurgery Articles

MR-guided laser interstitial therapy (MRgLITT) is becoming more commonly used for minimal access approaches to intracranial lesions of all etiologies. The short-term safety profile of MRgLITT is favorable compared with sweeping incisions and open craniotomies, especially for lesions located in deep, periventricular, and highly eloquent areas. The Visualase software (Medtronic Inc., Minneapolis, MN, USA) has multiple adaptations to assist with this safety margin, including the thermal damage estimate (TDE), which applies predictive mathematical modeling to a two-dimensional (2D) graphical representation. TDE has been shown to highly correlate with actual tissue destruction in a priori MRgLITT cases and to anecdotally be …

Croup, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Clinical Practice Guidelines)

No abstract provided.

Diverse Assessments That Encourage Creativity Among Gifted Students, Sowmya Anjur

Faculty Publications & Research

No abstract provided.

Temporal Trends In Lipoprotein(A) Concentrations: The Atherosclerosis Risk In Communities Study, Matthew R. Deshotels, Caroline Sun, Vijay Nambi, Salim S. Virani, Kunihiro Matsushita, Bing Yu, Christie . M. Ballantyne, Ron C. Hoogeveen

Office of the Provost

Background: Plasma lipoprotein(a) (Lp[a]) concentrations are primarily determined by genetic factors and are believed to remain stable throughout life. However, data are scarce on longitudinal trends in Lp(a) concentrations over time. Therefore, it is unclear whether measurement of Lp(a) once in a person's life is sufficient for cardiovascular risk assessment in all adults.
Methods and Results: Lp(a) concentrations, specifically apolipoprotein(a) concentrations, were measured at visits 4 and 5, ≈15 years apart, in 4734 adult participants of the ARIC (Atherosclerosis Risk in Communities) study (mean age at visits 4 and 5, 60.7±5.1 and 75.5±5.2 years, respectively). Participants were categorized by baseline …

Assessment And Constraint Of Mesozooplankton In Cmip6 Earth System Models, C. M. Petrik, J. Y. Luo, R. F. Heneghan, J. D. Everett, C. S. Harrison, A. J. Richardson

Faculty Publications

Although zooplankton play a substantial role in the biological carbon pump and serve as a crucial link between primary producers and higher trophic level consumers, the skillful representation of zooplankton is not often a focus of ocean biogeochemical models. Systematic evaluations of zooplankton in models could improve their representation, but so far, ocean biogeochemical skill assessment of Earth system model (ESM) ensembles have not included zooplankton. Here we use a recently developed global, observationally based map of mesozooplankton biomass to assess the skill of mesozooplankton in six CMIP6 ESMs. We also employ a biome-based assessment of the ability of these …

Divergent Effects Of Biological And Physical Processes On Dissolved Oxygen And Dissolved Inorganic Carbon Dynamics On A Eutrophied And Hypoxic Continental Shelf, Zoraida J. Quiñones-Rivera, Björn Wissel, R. Eugene Turner, Nancy N. Rabalais, Dubravko Justić, Kerri P. Finlay, Charles S. Milan

Faculty Publications

Dissolved oxygen (DO) and dissolved inorganic carbon (DIC) represent reciprocal sides of aquatic metabolism. In closed systems, absolute DO and DIC changes follow a ~ 1 : 1 ratio, but in open systems coupling depends on mixing, air–sea gas exchange, and anaerobic respiration. To quantify DO–DIC controls in coastal waters, we evaluated their concentrations and stable isotopes together with water quality and physical conditions across the hypoxic zone off the Louisiana continental shelf in July 2002 and July 2003. This area is characterized by high yet variable productivity and strong seasonal changes in vertical stratification and river discharge. Prior to …

Pemetrexed And Platinum Plus Pembrolizumab In Patients With Metastatic Nonsquamous Nsclc By Tumor Burden At Baseline: A Post Hoc Efficacy Analysis Of Keynote-189, Shirish M. Gadgeel, Jhanelle E. Gray, Maria Teresa Rizzo, Patrick Peterson, Jong Seok Kim, Delvys Rodríguez-Abreu

Hematology/Oncology Articles

INTRODUCTION: The aim of this study was to evaluate the efficacy of pemetrexed and platinum plus pembrolizumab by baseline tumor burden.

METHODS: A total of 616 patients in the intention-to-treat population of the KEYNOTE-189 study were included in this analysis. Baseline tumor burden subgroups were identified on the basis of extent of distant metastasis (M1a versus M1b), median number (≤3 versus >3) of organ systems with lesions, or symptom severity score of patient-reported lung cancer-associated symptoms (≤median versus >median). Overall survival (OS), progression-free survival (PFS), and PFS-2 were evaluated by Kaplan-Meier and univariate Cox methods. Objective response rate was analyzed …

The Effects Of Cheatgrass Invasion On Us Great Basin Carbon Storage Depend On Interactions Between Plant Community Composition, Precipitation Seasonality, And Soil Climate Regime, Toby M. Maxwell, Matthew J. Germino

Biology Faculty Publications and Presentations

1. Annual-grass invasions are transforming desert ecosystems in ways that affect ecosystem carbon (C) balance, but previous studies do not agree on the pattern, magnitude and direction of changes. A recent meta-analysis of 41 articles and 386 sites concludes that invasion by annual grasses such as cheatgrass (Bromus tectorum L) reduces C in biomass across the Great Basin (Nagy et al., 2021). Reanalysis reveals that whether cheatgrass affects biomass C stocks is not generalizable, but rather depends on the considerable variation in climate across the subject sites. Our analysis suggests that accurate Great Basin-scale estimates of cheatgrass effects on C …

Nucleobase-Modified Nucleosides And Nucleotides: Applications In Biochemistry, Synthetic Biology, And Drug Discovery, Anthony J. Berdis

Chemistry Faculty Publications

DNA is often referred to as the "molecule of life " since it contains the genetic blueprint for all forms of life on this planet. The core building blocks composing DNA are deoxynucleotides. While the deoxyribose sugar and phosphate group are ubiquitous, it is the composition and spatial arrangement of the four natural nucleobases, adenine (A), cytosine (C), guanine (G), and thymine (T), that provide diversity in the coding information present in DNA. The ability of DNA to function as the genetic blueprint has historically been attributed to the formation of proper hydrogen bonding interactions made between complementary nucleobases. However, …

Tremblings, November 2022, Western Aspen Alliance

Tremblings

Facing forest change with humility

Jess Kirby

I feel the ultimate beauty of forests is their need for constant change and their willingness to adapt to new conditions. However, if there is one thing I have learned in twenty-five years of public service with federal, state, and local government, when it comes to forests, people do not like change. But ecological change, whether humans like it or not, is integral to healthy and resilient forested landscapes.

Here’S The Tea: Antioxidant Capacity And Phenolic Content Of Various Commercial Teas, Shay Lynn Greco

Biochemistry and Molecular Biology

Tea is historically a widely consumed beverage globally, second only to water. Tea beverages are known to provide plentiful health benefits related to aging and general well-being. Drinking teas may also reduce the risk of many diseases such as developing cancers and vascular diseases. These ancient beverages have a variety of biological activities including anti-tumor, antioxidant and anti-obesity properties. The chemical mechanisms for these health benefits are related to the phenolic and flavonoid compounds present in teas. In this study, the infusions of commercial teas were analyzed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid (ABTS) assays to determine the …

The Constructivist Flipped Classroom, William Robertson

Departmental Papers (TE)

In science education, the value of the constructivist methodology has long been integrated with experiential and hands-on learning while offering a framework for teaching and learning. In recent pre- and future postpandemic times, as various online modalities have been leveraged in the teaching of science, there should be a complementary approach taken to content and experiences in the online environment. Specifically, a hybrid approach that integrates in-person experiences and instruction with online learning opportunities and content delivery, when integrated with constructivism, can provide an appropriate framework for the flipped classroom. By leading with face-to-face active learning opportunities to explore conceptual …

Modeling Vegetation Cover At Mount St Helens Using Highly Correlated Vegetation Indices, Sara Livingston

Geography and the Environment: Graduate Student Capstones

The eruption of Mount St. Helens in 1980 devastated the landscape and obliterated all ground vegetation within a 620 km2 blast zone radius. The destructive forces of the lateral blast, debris avalanche, tephra plume, and lahar flow created a complex mosaic of disturbance zones, that subsequently yielded various rates of landscape recovery. Remote sensing is an efficient method for monitoring landscape-scale changes by recording the distinct spectral reflectance of vegetation. Based on statistically significant correlations between Vegetation Indices and vegetation parameters, an empirical model can be developed for vegetation cover predictions. This capstone analysis found that NDVI holds the strongest …

A Benchtop Robotic Automation Approach For Manufacturing Prefilled Syringes, Yehua Zhong

All Theses

Automation and robotics have become a staple in the biological manufacturing sector due to their ability to efficiently work without operator inputs, with a high degree of accuracy and repeatability. Industrial robotic arms, in particular, present themselves as valuable tools for biological manufacturing scenarios that require customized solutions due to their ease of programming and flexibility. The traditional hospital-focused healthcare system was organically developed to address acute conditions, however, in recent years, due to the unprecedented occurrence of emergencies happening more frequently, fast and efficient drug production becomes important [17]. This thesis represents the use of a benchtop robot and …

2022 Survey For Midwestern Producers Descriptive Results, Tong Wang, Stephen Cheye

Midwestern Farm and Producer Surveys and Policy Briefs

From July to September 2021, researchers at South Dakota State University carried out a survey of producers in the Midwest to understand producers’ views and use of conservation farming and precision technology. To further understand how the input market supply volatilities has affected Midwest farmers' decisions and their potential adjustments to the current market situation, we carried out a re-survey in 2022 with the 1,119 respondents to the 2021 Midwestern survey. The participants of the survey were contacted in four separate rounds in line with the modified Tailored Design Method.

Fertility Counseling For Couples, Brennan Peterson, Kristy Koser

Marriage and Family Therapy Faculty Books and Book Chapters

This chapter addresses the role, and importance, of individual counseling and psychotherapy in providing psychological assistance and support to patients who are struggling with infertility and loss. Depression and anxiety are the two most frequent emotional sequelae of the infertility experience. The chapter therefore speaks not only to what factors contribute to making fertility counselors effective in their work, but also addresses specific treatment approaches that can yield positive outcomes in working with this unique population. These approaches include psychodynamic psychotherapy, cognitive–behavioral therapy (including dialectical behavior therapy and trauma-focused therapy), and supportive counseling. A brief history and description of each …

Development Of The Mentalizing Network Structures And Theory Of Mind In Extremely Preterm Youth, Xiaoxue Fu Ph.D., Andy Hung, Aryanne D. De Silva, Tyler Busch, Whitney I. Mattson, Kristen R. Hoskinson, Hudson Gerry, Eric E. Nelson

Faculty Publications

Adolescents born preterm (<37 weeks of gestation) are at elevated risk for deficits in social cognition and peer relationships. Theory of Mind (ToM) is a complex form of social cognition important for regulating social interactions. ToM and the underlying mentalizing network continue to develop across adolescence. The present study recruited 48 adolescents (12–17 years old) who were either born extremely preterm (EPT; <28 weeks of gestation) or full-term (FT) at birth. Cortical thickness, gray matter volume and surface area were measured in four regions of the mentalizing network: the temporoparietal junction, anterior temporal cortex, posterior superior temporal sulcus and frontal pole (mBA10). We also assessed the adolescents’ performance on a ToM task. Findings revealed both group differences and group-by-age interaction effects in the gray matter indices within the temporal lobe regions of the mentalizing network. The EPT group also performed significantly worse than the FT group on the ToM task. The cortical structural measures that discriminated the EPT and FT groups were not related to ToM performance. These results highlight altered developmental changes in brain regions underlying mentalizing functions in EPT adolescents relative to FT controls.

Neotype Designation For Papilio Fulgerator Walch, 1775 (Hesperiidae: Eudaminae), Jing Zhang, Qian Cong, Gerardo Lamas, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

The discovery that a skipper butterfly Telegonus fulgerator (Walch, 1775), previously placed in the genus Astraptes Hübner, [1819], is a complex of many similar-looking species-level taxa with different COI barcodes, caterpillar foodplants, and body patterns, and subtle differences in adult phenotypes raised a question about which species is the original T. fulgerator. To answer this question, being unable to locate its holotype, we designate the neotype of Papilio fulgerator Walch, 1775, a female specimen from Suriname in the Zoological State Collection, Munich, Germany. This neotype will form the foundation for a comprehensive revision of the T. fulgerator complex based …

The Nebraska Bird Review, Subscription And Organization Information (December 2022)

Nebraska Bird Review

The Nebraska Bird Review is published quarterly by the Nebraska Ornithologists’ Union, Inc., as its official journal, and is sent to members not in arrears of dues. Annual subscription rates (on a calendar-year basis only): $25 in the United States and $35 in all other countries, payable in advance. Single copies are $7 each, postpaid, in the United States and $9 elsewhere. Send orders for back issues to Anita Breckbill, NOU Librarian, c/o Music Library, WMB 30, University of Nebraska, Lincoln, NE 68588-0101 (or at the email address listed below).

Memberships in the NOU (on a calendar-year basis only): Active …

Fall Field Report, August-November 2022, W. Ross Silcock

Nebraska Bird Review

All in all, this was a fairly uneventful fall season, although even uneventful seasons have their share of oddities and variations from the norm. A noteworthy event was a fire that took out much of the brushy habitat in Carter Canyon, Scotts Bluff Co (see photo on following page). It will be interesting to read upcoming spring reports to see what effect the fire might have had on numbers of birds that frequent brushy areas, like towhees and buntings. Optimistically, fires have attracted rare woodpeckers, with first to arrive Black-backed, which would be a first documented Nebraska record, and typically …

Quantitative Analysis Of The Trade-Offs Of Colony Formation For Trichodesmium, Vitul Agarwal, Keisuke Inomura, Colleen B. Mouw

Graduate School of Oceanography Faculty Publications

There is considerable debate about the benefits and trade-offs for colony formation in a major marine nitrogen fixer, Trichodesmium. To quantitatively analyze the trade-offs, we developed a metabolic model based on carbon fluxes to compare the performance of Trichodesmium colonies and free trichomes under different scenarios. Despite reported reductions in carbon fixation and nitrogen fixation rates for colonies relative to free trichomes, we found that model colonies can outperform individual cells in several cases. The formation of colonies can be advantageous when respiration rates account for a high proportion of the carbon fixation rate. Negative external influence on vital …

Purification And Characterization Of An Anti-Basigin Monoclonal Antibody: Application To The Study Of Human Uterine Cells And Tissues, Jeannine M. Barna

All NMU Master's Theses

Between 1990 and 2017, the global rate of female infertility increased by over 15% (Sun et al., 2019). An embryo's failure to implant into the uterus is the primary cause of early pregnancy loss. Several studies have identified molecules necessary for successful implantation, but their function during implantation remains poorly understood (S. Zhang et al., 2013). The cell surface glycoprotein basigin-2 is necessary for embryo implantation in the mouse and plays a role in several cellular functions, including cell communication and extracellular matrix remodeling (Chen et al., 2009; K. Li & Nowak, 2020). In vitro studies using human uterine cells …