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2022

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High-Impact Learning Experiences And Post-Graduate Outcomes: Exploring The Influence On Employment, Continuing Education And Salary, Alison Handy Twang Nov 2022

High-Impact Learning Experiences And Post-Graduate Outcomes: Exploring The Influence On Employment, Continuing Education And Salary, Alison Handy Twang

The SUNY Journal of the Scholarship of Engagement: JoSE

With the cost of college on the rise, and students increasingly viewing college as a pathway to a successful career, colleges and universities are under increasing pressure to demonstrate evidence of their effectiveness. High-impact learning experiences, such as internships, study abroad, service-learning, capstones and undergraduate research, have emerged as a promising practice to enhance student development during college; however, few studies have examined the impact of such practices on post-graduate indicators of success. This paper adds to our understanding of the benefits of high-impact learning by examining their influence on student post-graduate employment, continuing education and starting salary. The data …


Chemical Components And Effects On Soil Quality In Temperate Grazed Pasture Systems, M. H. Beare, D. Curtin, S. Thomas, P. M. Fraser, G. S. Francis Nov 2022

Chemical Components And Effects On Soil Quality In Temperate Grazed Pasture Systems, M. H. Beare, D. Curtin, S. Thomas, P. M. Fraser, G. S. Francis

IGC Proceedings (1977-2023)

Key points

1. Legume/grass pastures retain feedbacks on N supply that may help to reduce losses of N to the wider environment.

2. Intensive use of N fertilisers tends to increase SOM turnover and increase losses of N to the environment.

3. Increased use of fertilisers has contributed little to soil organic matter storage in grazed pastoral systems.


Physical Constraints In Grassland Ecosystems, I. M. Young, K. Ritz, C. S. Sturrock, R. Heck Nov 2022

Physical Constraints In Grassland Ecosystems, I. M. Young, K. Ritz, C. S. Sturrock, R. Heck

IGC Proceedings (1977-2023)

Key points

1. Grassland system management must account adequately for biophysical and biochemical processes.

2. Amenity turf, especially sports turf, provides an excellent case study on how biology and physics interact to impact on the functioning of a grass ecosystem.

3. Microorganisms produce hydrophobic compounds that act to decrease water ingress and alter the function of the soil-grass ecosystem.


The Fierce Green Fire: Vol. 13 Issue 7, Wofford College. Department Of Environmental Studies Nov 2022

The Fierce Green Fire: Vol. 13 Issue 7, Wofford College. Department Of Environmental Studies

The Fierce Green Fire

No abstract provided.


Injection Of Electron Beams Into Two Laser Wakefields And Generation Of Electron Rings, Q. Chen, Dominika Maslarova, J. Wang, S. Li, Donald Umstadter Nov 2022

Injection Of Electron Beams Into Two Laser Wakefields And Generation Of Electron Rings, Q. Chen, Dominika Maslarova, J. Wang, S. Li, Donald Umstadter

Department of Physics and Astronomy: Faculty Publications

Mutual injection of electron beams into two laser plasma wakefields was observed experimentally when driving laser pulses interfered in plasma at a small crossing angle and were slightly relatively delayed, approximately by one pulse duration. Particle-in-cell simulations revealed that the mutual injection was sensitive to the spatial overlap of the laser pulses, which therefore could be used to control the mutual injection. The dual synchronized, femtosecond electron beams are potentially useful for pump-probe experiments in ultrafast science. In addition, out-of-axis ring-shaped electron beams were detected in both experiments and simulations.


Adding Gene Transcripts Into Genomic Prediction Improves Accuracy And Reveals Sampling Time Dependence., Bruno C Perez, Marco C A M Bink, Karen L. Svenson, Gary Churchill, Mario P L Calus Nov 2022

Adding Gene Transcripts Into Genomic Prediction Improves Accuracy And Reveals Sampling Time Dependence., Bruno C Perez, Marco C A M Bink, Karen L. Svenson, Gary Churchill, Mario P L Calus

Faculty Research 2022

Recent developments allowed generating multiple high-quality 'omics' data that could increase the predictive performance of genomic prediction for phenotypes and genetic merit in animals and plants. Here, we have assessed the performance of parametric and nonparametric models that leverage transcriptomics in genomic prediction for 13 complex traits recorded in 478 animals from an outbred mouse population. Parametric models were implemented using the best linear unbiased prediction, while nonparametric models were implemented using the gradient boosting machine algorithm. We also propose a new model named GTCBLUP that aims to remove between-omics-layer covariance from predictors, whereas its counterpart GTBLUP does not do …


Rural Teacher Attitudes And Engagement With Computing And Technology, Melissa P. Mendenhall, Colby Tofel-Grehl, David Feldon Nov 2022

Rural Teacher Attitudes And Engagement With Computing And Technology, Melissa P. Mendenhall, Colby Tofel-Grehl, David Feldon

Teacher Education and Leadership Faculty Publications

The purpose of this sequential Case Study-Mixed Methods research is to explore rural teacher attitudes toward, approaches to, and engagement with making and computational thinking during STEM professional development and co-teaching learning experiences. Specifically, we examine the professional learning needs of two rural, middle school teachers as they engage technology. Using the lens of cultural historical activity theory, this paper examines the ways in which teacher attitude about computing shifted throughout professional learning and instructional practice. Findings show three broad themes that emerge surrounding teacher attitudes, approaches, and engagement with technology: Anxiety, Independent Learner, and Integration. Additionally, findings suggest that …


Fecal Microbial Transplants Show Lack Of Predictability When No Prior Antibiotic Treatment Is Given To Recipient, Jeff Hansen Nov 2022

Fecal Microbial Transplants Show Lack Of Predictability When No Prior Antibiotic Treatment Is Given To Recipient, Jeff Hansen

Browse All News

No abstract provided.


Why Are There Microscopes In The Art Room?, Joyce Symoniak Nov 2022

Why Are There Microscopes In The Art Room?, Joyce Symoniak

Faculty Publications & Research

During this presentation we will explore how working cross curriculum enhances learning within the visual arts, science and mathematics. We will discuss how the visual arts curriculum can be created in order to bond with STEM courses for student success. Through exploration we will discuss how collaboration within these courses can be used to solidify cross curriculum understanding and learning.


Music Genre Classification By Convolutional Neural Networks, Usame Suud Nov 2022

Music Genre Classification By Convolutional Neural Networks, Usame Suud

Mathematics & Statistics ETDs

In today’s world, deep learning models are widely used in a variety of fields. Audio

applications include speech recognition, audio classification, and music information

retrieval. In this paper, we will focus on the classification of music genres using an

artificial neural network. The development of audio machine learning techniques has

created an independence from traditional, more time-consuming signal processing

techniques. Starting with raw audio data, we will gain an understanding of what

audio is and its digital representation. Then, the focus will be on obtaining frequency

information from audio signals through the use of spectrograms. Transforming the

spectrograms into the …


A Patent-Based Approach To Understanding The Role Of University, Company, And Government Collaboration In Biotechnological Innovation, Rachel Strader Nov 2022

A Patent-Based Approach To Understanding The Role Of University, Company, And Government Collaboration In Biotechnological Innovation, Rachel Strader

Theses

The biotechnology industry has shifted in recent years in corporate policy from a more traditional, closed research and development (R&D) model to an open innovation (OI) model, leading to increased collaboration between companies and academic institutions. The literature has reinforced this shift by demonstrating the role these collaborative relationships play in contributing to high-quality innovations. In this study, I use a unique dataset composed of biotechnology patents granted in the United States from 2000-2020 to examine the relationship between patent assignee and patent quality. Specifically, I measure patent quality using the number of forward citations and patent family size and …


Resilience Resources And Coping Strategies Of Covid-19 Female Long Haulers: A Qualitative Study, Atefeh Aghaei, Abhishek Aggarwal, Ran Zhang, Xiaoming Li Ph.D., Shan Qiao Ph.D. Nov 2022

Resilience Resources And Coping Strategies Of Covid-19 Female Long Haulers: A Qualitative Study, Atefeh Aghaei, Abhishek Aggarwal, Ran Zhang, Xiaoming Li Ph.D., Shan Qiao Ph.D.

Faculty Publications

Background: Female long haulers deal with persistent post-acute COVID-19 symptoms that have serious health implications. This study aimed to identify resilience resources at multiple socio-ecological levels for female long haulers and describe how resilience resources affect their responses to long COVID. Methods: Purposive sampling was adopted to recruit participants through social media from April to June 2021 followed by 15 semi-structured interviews. An inductive analytical approach was adopted to categorize themes by open and axial coding that were verified by peer review. Results: Female long haulers relied on resources at various socio-ecological levels to foster their resilience in response to …


Integrating Psychopathy Into Prominent Developmental/Life-Course Theories, Eva M. Fontaine Nov 2022

Integrating Psychopathy Into Prominent Developmental/Life-Course Theories, Eva M. Fontaine

USF Tampa Graduate Theses and Dissertations

Despite empirical research identifying psychopathy as one of the most robust predictors of criminal behavior, calls to integrate psychopathy into criminological theory have largely been unrequited. Within criminological theory, the construct of psychopathy has been proposed to best fit in the developmental/life-course (DLC) paradigm. As such, the purpose of this dissertation was to explore the theoretical integration of into psychopathy into three DLC theories: (1) Moffitt’s (1993) Dual Taxonomy, (2) Gottfredson & Hirschi’s (1990) General Theory of Crime, and (3) DeLisi’s (2009) Unified Theory of Crime. In doing so, the three studies in this dissertation employed the Pathways to Desistance …


Visual Ecology: Sensing The Social World, Elliott P. Steele Nov 2022

Visual Ecology: Sensing The Social World, Elliott P. Steele

Dartmouth College Ph.D Dissertations

Social animals, and even solitary animals, must at different points in their life actively search for and locate conspecifics within their environment, using one or multiple senses. One sense in particular, vision, can provide some of the most spatially detailed and temporally rapid information about the environment. Yet, the surrounding environment can also severely challenge animals’ abilities to find fellow conspecifics. Furthermore, once an animal successfully locates conspecifics, it must then make key decisions about when and where to enter group formations, decisions which may strongly impact their access to socially-acquired resources. Even after an animal has positioned itself within …


Fundamentals Of Communication, 2nd Ed., Teresa Fisher Nov 2022

Fundamentals Of Communication, 2nd Ed., Teresa Fisher

Open Educational Resources

This textbook explores human communication with a particular focus on interpersonal communication. Following a foundational chapter, subsequent chapters include examining the role of culture, identity, perception, verbal communication, nonverbal communication, and listening on interpersonal communication. The textbook also includes chapters on interpersonal relationships and conflict. The final chapter provides guidance on oral presentations. The first edition was titled "Fundamentals of Interpersonal Communication".


Paraquat-Resistant Italian Ryegrass (Lolium Multiflorum) Confirmed In Louisiana, Alphonse B. Coco Iii Nov 2022

Paraquat-Resistant Italian Ryegrass (Lolium Multiflorum) Confirmed In Louisiana, Alphonse B. Coco Iii

LSU Master's Theses

Paraquat is the only herbicide labeled for postemergence control of Italian ryegrass in sugarcane. In 2017, sugarcane farmers in Louisiana reported Italian ryegrass control failures with paraquat applications. Seeds were collected from sugarcane fields in White Castle, St. Gabriel, and Bunkie, Louisiana where control was not achieved (reduced susceptibility). Additionally, Italian ryegrass seeds were collected from a sugarcane field in Welcome, LA with a history of paraquat use and with no reported control issues (susceptible population). A dose-response study was conducted at the Louisiana State University Agricultural Center’s Sugar Research Station in February 2021 and was repeated in November 2021. …


Uremic Myopathy And Mitochondrial Dysfunction In Kidney Disease, Eurico Serrano, Diana Whitaker-Menezes, Zhao Lin, Megan Roche, Maria Paula Martinez Cantarin Nov 2022

Uremic Myopathy And Mitochondrial Dysfunction In Kidney Disease, Eurico Serrano, Diana Whitaker-Menezes, Zhao Lin, Megan Roche, Maria Paula Martinez Cantarin

Kimmel Cancer Center Faculty Papers

Alterations in muscle structure and function in chronic kidney disease (CKD) patients are associated with poor outcomes. As key organelles in muscle cell homeostasis, mitochondrial metabolism has been studied in the context of muscle dysfunction in CKD. We conducted a study to determine the contribution of oxidative metabolism, glycolysis and fatty acid oxidation to the muscle metabolism in CKD. Mice developed CKD by exposure to adenine in the diet. Muscle of CKD mice showed significant weight loss compared to non-CKD mice, but only extensor digitorum longus (EDL) muscle showed a decreased number of fibers. There was no difference in the …


Screening Of Adapalene Microsponges Fabrication Parameters With Insight On The In Vitro Biological Effectiveness, Dalia Attia, Rania M Yehia, Mohey Elmazar, Mohamed A El-Nabarawi, Mahmoud H Teaima Nov 2022

Screening Of Adapalene Microsponges Fabrication Parameters With Insight On The In Vitro Biological Effectiveness, Dalia Attia, Rania M Yehia, Mohey Elmazar, Mohamed A El-Nabarawi, Mahmoud H Teaima

Pharmacy

Purpose: The objective of the present study was to scrutinize the microsponges (MS) as a carrier system using Adapalene (ADA) as a model drug. Methods: Data modelling was implemented using Plackett-Burman design to identify the main variables affecting the formulation of ADA-MS. The adopted method of preparation for MS was quasi-emulsion solvent diffusion method. The nominated independent variables were volume of organic phase, sonication time, stirring speed, drug percent, polymer type, emulsifier concentration, and method of organic phase addition. As for the dependent variables, they included entrapment efficiency (E.E.%), production yield (P.Y. %), particle size (P.S.) and morphology. Furthermore, selected …


Landscape-Level Long-Term Biological Research And Monitoring Plan For The Crane Trust, Andrew J. Caven, Joshua D. Wiese, Bethany L. Ostrom, Kelsey C. King, Jenna M. Malzahn, David M. Baasch, Brice Krohn Nov 2022

Landscape-Level Long-Term Biological Research And Monitoring Plan For The Crane Trust, Andrew J. Caven, Joshua D. Wiese, Bethany L. Ostrom, Kelsey C. King, Jenna M. Malzahn, David M. Baasch, Brice Krohn

Zea E-Books Collection

Our obligation is to make sure we are effectively utilizing science to meet the objectives of the Platte River Whooping Crane Maintenance Trust (1981) laid out in its charter “to rehabilitate and preserve a portion of the habitat for Whooping Cranes and other migratory birds in the Big Bend reach of the Platte River between Overton and Chapman (i.e., Central Platte River Valley), Nebraska”. The original declaration is aimed at maintaining “the physical, hydrological, and biological integrity of the Big Bend area as a life-support system for the Whooping Crane and other migratory species that utilize it.” It was clear …


Blockade Of Fgf2/Fgfr2 Partially Overcomes Bone Marrow Mesenchymal Stromal Cells Mediated Progression Of T-Cell Acute Lymphoblastic Leukaemia, Chen Tian, Yueyang Li, Lina Wang, Junqi Si, Yaxin Zheng, Junnan Kang, Yafei Wang, M James You, Guoguang Zheng Nov 2022

Blockade Of Fgf2/Fgfr2 Partially Overcomes Bone Marrow Mesenchymal Stromal Cells Mediated Progression Of T-Cell Acute Lymphoblastic Leukaemia, Chen Tian, Yueyang Li, Lina Wang, Junqi Si, Yaxin Zheng, Junnan Kang, Yafei Wang, M James You, Guoguang Zheng

Faculty, Staff and Student Publications

The development of acute lymphoblastic leuakemia (ALL) is partly attributed to the effects of bone marrow (BM) microenvironment, especially mesenchymal stromal cells (MSCs), which interact bilaterally with leukaemia cells, leading to ALL progression. In order to find MSCs-based microenvironment targeted therapeutic strategies, Notch1-induced T-cell ALL (T-ALL) mice models were used and dynamic alterations of BM-MSCs with increased cell viability during T-ALL development was observed. In T-ALL mice derived stroma-based condition, leukaemia cells showed significantly elevated growth capacity indicating that MSCs participated in leukaemic niche formation. RNA sequence results revealed that T-ALL derived MSCs secreted fibroblast growth factor 2 (FGF2), which …


Human Amniotic Membrane As A Dural Substitute In Neurosurgery: A Systematic Review, Zara Shah, Saqib Kamran Bakhshi, Mohammad Hamza Bajwa, Mujtaba Khalil, Michael C. Dewan, Muhammad Shahzad Shamim Nov 2022

Human Amniotic Membrane As A Dural Substitute In Neurosurgery: A Systematic Review, Zara Shah, Saqib Kamran Bakhshi, Mohammad Hamza Bajwa, Mujtaba Khalil, Michael C. Dewan, Muhammad Shahzad Shamim

Medical College Documents

Background: Several studies have highlighted the use of human amniotic membrane (HAM) in neurosurgical procedures as an effective dural substitute. HAM has inherent antifibrotic and anti-inflammatory properties and exhibits immunomodulatory effect that makes it an ideal dural substitute. Other advantages including easy availability, low cost of procurement, and storage also render it a promising dural substitute especially in low- and middle-income countries.
Methods: A systematic literature search was performed using PubMed, Scopus, and Google Scholar databases, using the search terms "human amniotic membrane," "dural repair," and "neurosurgery." To be eligible for inclusion in our review, papers had to report primary …


Uses And Benefits Of Algae As A Nutritional Supplement For Honey Bees, Benjamin J. Nichols, Vincent A. Ricigliano Nov 2022

Uses And Benefits Of Algae As A Nutritional Supplement For Honey Bees, Benjamin J. Nichols, Vincent A. Ricigliano

Department of Entomology: Faculty Publications

Honey bees are essential agricultural pollinators that are threatened by various interacting stressors, posing risks to beekeeping industries and human food security. Malnutrition is a major factor underlying managed bee colony losses that can be countered by feeding artificial diets, which aim to deliver essential macro- and micronutrients. Current bee nutritional supplements show room for improvement and require resources that compete with human food production. Algae and microalgae in particular have been gaining traction in the literature as alternative feed sources and nutritional supplements for livestock, including honey bees. Herein, we review the current literature and categorize the effects of …


Do Pharmaceuticals In The Environment Pose A Risk To Wildlife?, Thomas G. Bean, Elizabeth A. Chadwick, Marta Herrero‐Villar, Rafael Mateo, Vinny Naidoo, Barnett A. Rattner Nov 2022

Do Pharmaceuticals In The Environment Pose A Risk To Wildlife?, Thomas G. Bean, Elizabeth A. Chadwick, Marta Herrero‐Villar, Rafael Mateo, Vinny Naidoo, Barnett A. Rattner

United States Geological Survey: Staff Publications

The vast majority of knowledge related to the question “To what extent do pharmaceuticals in the environment pose a risk to wildlife?” stems from the Asian vulture crisis (>99% decline of some species of Old World vultures on the Indian subcontinent related to the veterinary use of the nonsteroidal anti‐inflammatory drug [NSAID] diclofenac). The hazard of diclofenac and other NSAIDs (carprofen, flunixin, ketoprofen, nimesulide, phenylbutazone) to vultures and other avian species has since been demonstrated; indeed, only meloxicam and tolfenamic acid have been found to be vulture‐safe. Since diclofenac was approved for veterinary use in Spain and Italy in …


Exploring Membrane Binding Targets Of Disordered Human Tau Aggregates On Lipid Rafts Using Multiscale Molecular Dynamics Simulations, Kwan H. Cheng, Angela Graf, Amber Lewis, Thuong Pham, Aakriti Acharya Nov 2022

Exploring Membrane Binding Targets Of Disordered Human Tau Aggregates On Lipid Rafts Using Multiscale Molecular Dynamics Simulations, Kwan H. Cheng, Angela Graf, Amber Lewis, Thuong Pham, Aakriti Acharya

Physics and Astronomy Faculty Research

The self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of Alzheimer’s Disease. Recent studies indicate that the disordered tau aggregates, or oligomers, are more toxic than the ordered fibrils found in the intracellular neurofibrillary tangles of tau. At present, details of tau oligomer interactions with lipid rafts, a model of neuronal membranes, are not known. Using molecular dynamics simulations, the lipid-binding events, membrane-damage, and protein folding of tau oligomers on various lipid raft surfaces were investigated. Tau oligomers preferred to bind to the boundary domains (Lod) created by the coexisting liquid-ordered (Lo) and liquid-disordered (Ld) domains …


Business Benefits Associated With Improving Fatigue Regulations For Cargo Pilots, Arthur Chiari, Bruna De Gois E Silva, Nelson Christianini Nov 2022

Business Benefits Associated With Improving Fatigue Regulations For Cargo Pilots, Arthur Chiari, Bruna De Gois E Silva, Nelson Christianini

Student Works

The central idea of this research is to assess business-related factors in the Pilots ́ Fatigue Regulations and evaluate if a more flexible regulation would improve productivity of airline cargo pilots in Brazil.

The results of the study have indicated that Brazilian Civil Aviation Authority (ANAC) can create a regulatory environment that may lead up to 34,28% of improved productivity of pilots ́ availability in cargo operations, which may contribute for gains up to USD $3.6 million for an airline with cargo 70 pilots flying 16.500 hours per year.

Aviation fatigue regulations are an extremely important subject in the aviation …


Diagnostic Accuracy Of Artificial Intelligence For Detecting Gastrointestinal Luminal Pathologies: A Systematic Review And Meta-Analysis, Om Parkash, Asra Tus Saleha Siddiqui, Uswa Jiwani, Fahad Rind, Zahra Ali Padhani, Arjumand Rizvi, Zahra Hoodbhoy, Jai K. Das Nov 2022

Diagnostic Accuracy Of Artificial Intelligence For Detecting Gastrointestinal Luminal Pathologies: A Systematic Review And Meta-Analysis, Om Parkash, Asra Tus Saleha Siddiqui, Uswa Jiwani, Fahad Rind, Zahra Ali Padhani, Arjumand Rizvi, Zahra Hoodbhoy, Jai K. Das

Section of Gastroenterology

Background: Artificial Intelligence (AI) holds considerable promise for diagnostics in the field of gastroenterology. This systematic review and meta-analysis aims to assess the diagnostic accuracy of AI models compared with the gold standard of experts and histopathology for the diagnosis of various gastrointestinal (GI) luminal pathologies including polyps, neoplasms, and inflammatory bowel disease.
Methods: We searched PubMed, CINAHL, Wiley Cochrane Library, and Web of Science electronic databases to identify studies assessing the diagnostic performance of AI models for GI luminal pathologies. We extracted binary diagnostic accuracy data and constructed contingency tables to derive the outcomes of interest: sensitivity and specificity. …


Beyond Health And Animal Rights: A Study In Black Veganism, Wendy J. Rib Nov 2022

Beyond Health And Animal Rights: A Study In Black Veganism, Wendy J. Rib

USF Tampa Graduate Theses and Dissertations

Veganism, or the avoidance of animal products, has been recognized by nutritionists and food scientists as a lifestyle choice associated with good health and lower prevalence of diabetes, obesity, hypertension, and heart disease. However, the choice to eschew all animal products is frequently more than just a diet. Many people practice veganism as part of a larger reformative social movement, seeking permanent change in food structures, advancing policies in animal welfare and transforming their everyday lives in the quest for cultural acceptance. Although the number of people who identify as vegans appears to be growing, it is often assumed that …


Reprogramming Of Pancreatic Adenocarcinoma Immunosurveillance By A Microbial Probiotic Siderophore, Mehdi Chaib, Bilal B. Hafeez, Hassan Mandil, Deidre Daria, Ajeeth K. Pingili, Sonam Kumari, Mohammed Sikander, Vivek K. Kashyap, Emmanuel Anning, Manish Tripathi, Sheema Khan, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan Nov 2022

Reprogramming Of Pancreatic Adenocarcinoma Immunosurveillance By A Microbial Probiotic Siderophore, Mehdi Chaib, Bilal B. Hafeez, Hassan Mandil, Deidre Daria, Ajeeth K. Pingili, Sonam Kumari, Mohammed Sikander, Vivek K. Kashyap, Emmanuel Anning, Manish Tripathi, Sheema Khan, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

There is increasing evidence suggesting the role of microbiome alterations in relation to pancreatic adenocarcinoma and tumor immune functionality. However, molecular mechanisms of the interplay between microbiome signatures and/or their metabolites in pancreatic tumor immunosurveillance are not well understood. We have identified that a probiotic strain (Lactobacillus casei) derived siderophore (ferrichrome) efficiently reprograms tumor-associated macrophages (TAMs) and increases CD8 + T cell infiltration into tumors that paralleled a marked reduction in tumor burden in a syngeneic mouse model of pancreatic cancer. Interestingly, this altered immune response improved anti-PD-L1 therapy that suggests promise of a novel combination (ferrichrome and …


The Mid‑Pleistocene Transition: A Delayed Response To An Increasing Positive Feedback?, Anne Willem Omta, Peter Thomas Nov 2022

The Mid‑Pleistocene Transition: A Delayed Response To An Increasing Positive Feedback?, Anne Willem Omta, Peter Thomas

Faculty Scholarship

Glacial–interglacial cycles constitute large natural variations in Earth’s climate. The Mid-Pleistocene Transition (MPT) marks a shift of the dominant periodicity of these climate cycles from ∼40 to ∼100 kyr. Recently, it has been suggested that this shift resulted from a gradual increase in the internal period (or equivalently, a decrease in the natural frequency) of the system. As a result, the system would then have locked to ever higher multiples of the external forcing period. We find that the internal period is sensitive to the strength of positive feedbacks in the climate system. Using a carbon cycle model in which …


Single-Cell Multiomics Identifies Clinically Relevant Mesenchymal Stem-Like Cells And Key Regulators For Mpnst Malignancy, Lai Man Natalie Wu, Joshua Rubin, Et Al. Nov 2022

Single-Cell Multiomics Identifies Clinically Relevant Mesenchymal Stem-Like Cells And Key Regulators For Mpnst Malignancy, Lai Man Natalie Wu, Joshua Rubin, Et Al.

2020-Current year OA Pubs

Malignant peripheral nerve sheath tumor (MPNST), a highly aggressive Schwann cell (SC)-derived soft tissue sarcoma, arises from benign neurofibroma (NF); however, the identity, heterogeneity and origins of tumor populations remain elusive. Nestin