Digital Commons Network^™

2022-2023 Graduate Catalog, Morehead State University.

Morehead State Catalog Archive

2022-2023 graduate catalog for Morehead State University.

Distributed Partial Differential Equation Solving With Julia Fast Fourier Transform Library, Christopher E. Mottola

Honors Theses and Capstones

Scientific computing relies on advanced computational and mathematical techniques to solve complex problems in scientific domains. For the numerical rendering of spectral, nonlinear, and dynamic phenomena, there is a growing need for greater availability of a broad class of Fourier-based algorithms to perform large scale operations on multidimensional data in distributed and optimized ways. To this effect, the Julia programming language is new and has significant advantages compared to other common languages used in scientific computing. The research presented here formulates a basis for further development in high-performance scientific computing of periodic partial differential equations through the application of distributed …

On Foxes And Hedgehogs, Roger P. Alford

Journal Articles

This Article is about John Nagle’s many means to one great end. It will outline the many themes of his scholarship: (i) environmental law, (ii) statutory interpretation, (iii) constitutional law, (iv) nuisance and pollution, (v) election law and campaign finance, (vi) Christianity and the environment, and (vii) national parks. It will offer conclusions on how he used his scholarly interests as a means to pursue his overarching worldview.

A Framework For Near-Real Time Monitoring Of Diversity Patterns Based On Indirect Remote Sensing, With An Application In The Brazilian Atlantic Rainforest, Andrea Paz, Thiago S. Silva, Ana C. Carnaval

Publications and Research

Monitoring biodiversity change is key to effective conservation policy. While it is difficult to establish in situ biodiversity monitoring programs at broad geographical scales, remote sensing advances allow for near-real time Earth observations that may help with this goal. We combine periodical and freely available remote sensing information describing temperature and precipitation with curated biological information from several groups of animals and plants in the Brazilian Atlantic rainforest to design an indirect remote sensing framework that monitors potential loss and gain of biodiversity in near-real time. Using data from biological collections and information from repeated field inventories, we demonstrate that …

Harnessing The Power Of Interdisciplinary Research With Psychology-Informed Cyberbullying Detection Models, Deborah Hall, Yasin N. Silva, Brittany Wheeler, Lu Cheng, Katie Baumel

Computer Science: Faculty Publications and Other Works

Cyberbullying has become increasingly prevalent, particularly on social media. There has also been a steady rise in cyberbullying research across a range of disciplines. Much of the empirical work from computer science has focused on developing machine learning models for cyberbullying detection. Whereas machine learning cyberbullying detection models can be improved by drawing on psychological theories and perspectives, there is also tremendous potential for machine learning models to contribute to a better understanding of psychological aspects of cyberbullying. In this paper, we discuss how machine learning models can yield novel insights about the nature and defining characteristics of cyberbullying and …

Magi1 Inhibits Interferon Signaling To Promote Influenza A Infection, Yin Wang, Jun-Ichi Abe, Khanh M Chau, Yongxing Wang, Hang Thi Vu, Loka Reddy Velatooru, Fahad Gulraiz, Masaki Imanishi, Venkata S K Samanthapudi, Minh T H Nguyen, Kyung Ae Ko, Ling-Ling Lee, Tamlyn N Thomas, Elizabeth A Olmsted-Davis, Sivareddy Kotla, Keigi Fujiwara, John P Cooke, Di Zhao, Scott E Evans, Nhat-Tu Le

Faculty, Staff and Student Publications

We have shown that membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1), a scaffold protein with six PSD95/DiscLarge/ZO-1 (PDZ) domains, is involved in the regulation of endothelial cell (EC) activation and atherogenesis in mice. In addition to causing acute respiratory disease, influenza A virus (IAV) infection plays an important role in atherogenesis and triggers acute coronary syndromes and fatal myocardial infarction. Therefore, the aim of this study is to investigate the function and regulation of MAGI1 in IAV-induced EC activation. Whereas, EC infection by IAV increases MAGI1 expression, MAGI1 depletion suppresses IAV infection, suggesting that the induction of MAGI1 may …

The Potential Of Biology-Guided Radiation Therapy In Thoracic Cancer: A Preliminary Treatment Planning Study, Steven N Seyedin, Rostem Bassalow, Osama R Mawlawi, Lehendrick M Turner, Roshal R Patel, Samuel R Mazin, Oluwaseyi M Oderinde, Yevgen Voronenko, Cody A Wages, Peter D Olcott, Joe Y Chang, Peter A Balter, James W Welsh

Faculty, Staff and Student Publications

PURPOSE: We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk.

METHODS: Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions).

RESULTS: For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT …

The Architecture And Dynamics Of Gene Regulatory Networks Directing Cell-Fate Choice During Murine Hematopoiesis, Joanna Handzlik

Theses and Dissertations

Mammals produce hundreds of billions of new blood cells every day througha process known as hematopoiesis. Hematopoiesis starts with stem cells that develop into all the different types of cells found in blood by changing their genome-wide gene expression. The remodeling of genome-wide gene expression can be primarily attributed to a special class of proteins called transcription factors (TFs) that can activate or repress other genes, including genes encoding TFs. TFs and their targets therefore form recurrent networks called gene regulatory networks (GRNs). GRNs are crucial during physiological developmental processes, such as hematopoiesis, while abnormalities in the regulatory interactions of …

Systems Modeling As A Means Of Building Accuate Mental Models Of Physiology Core Concepts In Undergraduate And Graduate Health Sciences Students, Michelle Murphy

Theses and Dissertations

Accurate medical and health sciences problem solving relies upon a solid foundation of basic sciences content knowledge, primarily physiology. Yet, due to its nature as a dynamic system of interconnected, networked, concepts, physiology is often difficult for students to master. The three studies in this dissertation explore the use of a cognitive tool, systems modeling, to facilitate the development of an accurate mental model of physiology content knowledge in undergraduate and graduate physiology students. In the first study, undergraduate physiology student participation within online asynchronous peer group systems modeling activities was associated with progressive improvement on multiple choice question answer …

Text Is Not Enough, Anuj C. Desai

University of Colorado Law Review

In Bostock v. Clayton County, the Supreme Court held that Title VII of the Civil Rights Act of 1964 protects gay and lesbian individuals from employment discrimination. The three opinions in the case also provided a feast for Court watchers who study statutory interpretation. Commentators across the ideological spectrum have described the opinions as dueling examples of textualism. The conventional wisdom is thus that Bostock shows the triumph of textualism. The conventional wisdom is wrong. Instead, Bostock shows what those who have studied statutory interpretation have known for decades: judges are multimodalists, drawing from a panoply of forms of …

Leveling Up To A Reasonable Woman's Expectation Of Privacy, Victoria Schwartz

University of Colorado Law Review

Various privacy law doctrines involve a reasonable expectation of privacy or similar analyses that take into account social privacy norms. For the most part, however, neither courts nor scholars have explicitly grappled with whether courts descriptively do or normatively should consider gender in deciding what constitutes a reasonable expectation of privacy. This is despite the fact that, in various scenarios, a reasonable woman’s expectation of privacy might vary from a man’s in light of different lived experiences, biological differences, and existing societal gendered privacy norms.

This Article addresses how courts do and should take into account a reasonable woman’s expectation …

The Most Dangerous Branch Of Science? Reining In Rogue Research And Reckless Experimentation In Social Services, James G. Dwyer

Missouri Law Review

Most people are unaware how much public policy is either lacking in any empirical-research support or driven by bad research. Political actors motivated by ideology or donor/constituent demands propose new government practices—in areas ranging from policing to funding of treatments for gender dysphoria in youth to welfare-qualification rules—that will greatly impact people’s lives, and if anyone asks what basis they have for thinking the impact will be good, they can readily find some study to support their case. Especially when powerless populations are put at risk, neither the legislative process nor peer review in the publication process provides a real …

A Transgenic Bacterial Artificial Chromosome Approach To Identify Regulatory Regions That Direct Amhr2 And Osterix Expression In Müllerian Duct Mesenchyme, Malcolm M Moses, Rachel D Mullen, Daniel I Idowu, Peter Maye, Soazik P Jamin, Richard R Behringer

Faculty, Staff and Student Publications

A transgenic mouse approach using bacterial artificial chromosomes (BAC) was used to identify regulatory regions that direct Müllerian duct expression for Amhr2 and Osterix (Osx, also known as Sp7). Amhr2 encodes the receptor that mediates anti-Müllerian hormone (AMH) signaling for Müllerian duct regression in male embryos. Amhr2 is expressed in the Müllerian duct mesenchyme of both male and female embryos. A ∼147-kb BAC clone containing the Amhr2 locus was used to generate transgenic mice. The transgene was able to rescue the block in Müllerian duct regression of Amhr2-null males, suggesting that the BAC clone contains regulatory …

Genetic Variants Associated With Circulating Liver Injury Markers In Mexican Americans, A Population At Risk For Non-Alcoholic Fatty Liver Disease, Caroline M Sabotta, Suet-Ying Kwan, Lauren E Petty, Jennifer E Below, Aron Joon, Peng Wei, Susan P Fisher-Hoch, Joseph B Mccormick, Laura Beretta

Faculty, Staff and Student Publications

Objective: Mexican Americans are disproportionally affected by non-alcoholic fatty liver disease (NAFLD), liver fibrosis and hepatocellular carcinoma. Noninvasive means to identify those in this population at high risk for these diseases are urgently needed. Approach: The Cameron County Hispanic Cohort (CCHC) is a population-based cohort with high rates of obesity (51%), type 2 diabetes (28%) and NAFLD (49%). In a subgroup of 564 CCHC subjects, we evaluated 339 genetic variants previously reported to be associated with liver injury markers aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in United Kingdom and Japanese cohorts. Results: Association was confirmed for 86 variants. Among …

Predicting Clinical Response To Everolimus In Er+ Breast Cancers Using Machine-Learning, Aritro Nath, Patrick A Cosgrove, Jeffrey T Chang, Andrea H Bild

Faculty, Staff and Student Publications

Endocrine therapy remains the primary treatment choice for ER+ breast cancers. However, most advanced ER+ breast cancers ultimately develop resistance to endocrine. This acquired resistance to endocrine therapy is often driven by the activation of the PI3K/AKT/mTOR signaling pathway. Everolimus, a drug that targets and inhibits the mTOR complex has been shown to improve clinical outcomes in metastatic ER+ breast cancers. However, there are no biomarkers currently available to guide the use of everolimus in the clinic for progressive patients, where multiple therapeutic options are available. Here, we utilized gene expression signatures from 9 ER+ breast cancer cell lines and …

Targeting The Bcl6 Transcription Factor In Ovarian Cancer, Harrison H. Parent

Honors Theses and Capstones

Ovarian cancer is one of the most common reproductive malignancies for women in the United States, as well as one of the deadliest. Many deaths attributed to ovarian cancer, as well as cancer generally, are due to metastasis of the original tumor to different tissues throughout the body. The BCL6 transcription factor has been identified to play a key role in the metastasis of these tumors, as well as the invasion of these cancer cells through mesothelial cell layers, which contributes to ovarian cancer’s unique metastatic behavior. In an attempt to target these metastases and prevent mesothelial penetration, drugs were …

Investigating The Main Protease (Mpro) Of Sars-Cov-2 As A Potential Drug Target, Valerie Giovina Pascetta

Honors Theses and Capstones

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 19 (COVID-19) pandemic has claimed the lives of roughly 6.2 million people worldwide as of May 2022. The virus’s main protease (M^pro ) has been identified as an attractive drug target due to the critical role it plays in the viral life cycle. The roughly 34 kDa M^pro cleaves functional viral polypeptides out of two long polyproteins at conserved cut sites, allowing them to fulfill their role in processes like transcription and replication. Here, we have studied the enzymatic activity …

Telehealth Delivery Of Acceptance And Commitment Therapy And Recreational Therapy: Supporting People With Chronic Pain During The Covid-19 Pandemic, Grace L. Roy

Honors Theses and Capstones

Chronic pain is a significant public health problem that requires person-centered and comprehensive care to address the many socioecological factors that contribute to pain. Within the context of the COVID-19 pandemic, telehealth options for chronic pain management can help more people access the care that they need. The purpose of the current pilot study was to investigate the efficacy and feasibility of delivering a 6-week Acceptance and Commitment Therapy (ACT) and recreational therapy intervention via telehealth for a group of seven participants with chronic pain. It was found that TeleACT-RT was associated with positive behavioral outcomes including increased psychological flexibility, …

Finding The Best Predictors For Foot Traffic In Us Seafood Restaurants, Isabel Paige Beaulieu

Honors Theses and Capstones

COVID-19 caused state and nation-wide lockdowns, which altered human foot traffic, especially in restaurants. The seafood sector in particular suffered greatly as there was an increase in illegal fishing, it is made up of perishable goods, it is seasonal in some places, and imports and exports were slowed. Foot traffic data is useful for business owners to have to know how much to order, how many employees to schedule, etc. One issue is that the data is very expensive, hard to get, and not available until months after it is recorded. Our goal is to not only find covariates that …

Variables That Affect Parental Goals For Visiting A Children’S Museum, Isabella M. Livingston

Honors Theses and Capstones

Children’s museums are informal educational environments that foster creativity, support sensory exploration, and provide places for both free play and learning (Gong et al., 2020). This study aimed to more fully understand parental goals for taking their children to a children’s museum, and how those goals varied based on characteristics known to play a role in how parents and children interact together. Subjects included 70 child-parent dyads. Each parent completed a demographic questionnaire, the Child Behavior Questionnaire-Very Short Form (Putnam & Rothbart, 2006) to assess temperament, and responded to an open-ended prompt related to visit intent. Dyads were then recorded …

A Review Of Monte Carlo Methods And Their Application In Medical Physics For Simulating Radiation Transport, Joe Shields

Honors Theses and Capstones

Monte Carlo methods are used to calculate statistical behavior through the use of random number generators and probability density functions. They have been used extensively in medical physics for research in radiotherapy, designing technology, dosimetry, and advanced clinical applications. This paper provides a background on Monte Carlo methods and a review of radiation therapy physics and dosimetry. Additionally, there is a discussion of the different ways Monte Carlo methods are used in medical physics as well as a review of current research related to Monte Carlo methods. The final portion of this paper contains my own Monte Carlo simulation using …

Review Of Gender Related Trends Among People Hospitalized For Infections With Concurrent Substance Use, Meghan Lotti

Honors Theses and Capstones

Abstract

Background: The opioid epidemic has been on the rise in the past decades, and with the rise of opioid use, infections related to substance use has also been on the rise. Infection trends in relation to gender currently have little evidence on how they affect each other.

Methods: Data was gathered from the New Hampshire Discharge Dataset on patients aged 18 to 85 who were admitted to any hospital with an infection diagnosis and concurrent substance use, from the years 2012 to 2019. This data was then graphed to analyze the trends.

Results: Infection rates had a consistent rise …

Multidisciplinary Engagement For Fencing Research Informs Efficacy And Rancher-To-Researcher Knowledge Exchange, Matthew Hyde, Stewart W. Breck, Alex Few, Jared Beaver, Joshua Schrecengost, Jim Stone, Cameron Krebs, Russell Talmo, Kari Eneas, Rae Nickerson, Kyran E. Kunkel, Julie K. Young

United States Department of Agriculture Wildlife Services: Staff Publications

Across much of the Western United States, recovery of large carnivore populations is creating new challenges for livestock producers. Reducing the risks of sharing the landscape with recovering wildlife populations is critical to private working lands, which play an vital role in securing future energy, water, food, and fiber for an ever-expanding human population. Fencing is an important mitigation practice that many ranchers, land managers, and conservationists implement to reduce carnivore-livestock conflict. While fencing strategies have been reviewed in the literature, research seldom incorporates knowledge from the people who utilize fencing the most (i.e., livestock producers). Incorporating producers and practitioners …

Conserving Endangered Black-Footed Ferrets: Biological Threats, Political Challenges, And Lessons Learned, Travis M. Livieri, Steven C. Forrest, Marc R. Matchett, Stewart Breck

United States Department of Agriculture Wildlife Services: Staff Publications

There may be few stories in the annals of wildlife management that are as dramatic as the near demise and comeback of the black-footed ferret (Mustela nigripes). Endemic only to North America, this charming little carnivore found only in the continent’s central grasslands was hardly known to science until the mid-20th century. By then, vast colonies of the prey it depended on for food and shelter, the prairie dog (Cynomys spp.), had been wiped out through disease (sylvatic plague) and an agricultural industry with little tolerance for burrowing and grazing rodents. At its low point, the species’ …

Fair Allocation Of Scarce Therapies For Coronavirus Disease 2019 (Covid-19), Govind Persad, Monica E. Peek, Seema K. Shah

Publications

The US Food and Drug Administration (FDA) has issued emergency use authorizations (EUAs) for monoclonal antibodies (mAbs) for nonhospitalized patients with mild or moderate coronavirus disease 2019 (COVID-19) disease and for individuals exposed to COVID-19 as postexposure prophylaxis. EUAs for oral antiviral drugs have also been issued. Due to increased demand because of the Delta variant, the federal government resumed control over the supply and asked states to ration doses. As future variants (e.g., the Omicron variant) emerge, further rationing may be required. We identify relevant ethical principles (i.e., benefiting people and preventing harm, equal concern, and mitigating health inequities) …

A Comprehensive Covid-19 Response—The Need For Economic Evaluation, Govind Persad, Ankur Pandya

Publications

Recently, the World Health Organization has exhorted countries to fight the Covid-19 pandemic with other interventions in addition to vaccines. But for countries to mount a comprehensive and effective response, more than exhortation is needed. Policymakers must understand the benefits and burdens associated with various policy options. They also have to be equipped to rigorously and systematically compare these benefits and burdens, both when evaluating individual policies and when determining which policies to include in a legislative or regulatory package.

Capital Discrimination, Ann Lipton

Publications

The law of business associations does not recognize gender. The rights and responsibilities imposed by states on business owners, directors, and officers do not vary based on whether the actors are male or female, and there is no explicit recognition of the influence of gender in the doctrine.

Sex and gender nonetheless may pervade business disputes. One co-owner may harass another co-owner; women equity holders may be forced out of the company; men may refuse to pay dividends to women shareholders.

In some contexts, courts do account for these dynamics, such as when married co-owners file for divorce. But business …

Quantum Technology And Human Rights: An Agenda For Collaboration, Vivek Krishnamurthy

Publications

Quantum technologies have the potential to transform many aspects of our lives as they come into wider use, but how do we ensure that these technologies promote human rights instead of harming them? This article will draw lessons from our collective experience in managing the human rights impacts of internet technologies to help the quantum science and technology community build and develop technologies that respect and promote the fundamental rights of all people.

Family Structure And Maternal Depressive Symptoms: A Cross-National Comparison Of Australia, The United Kingdom, And The United States, Kirsten Rasmussen, Elizabeth K. Sigler, Sadie A. Slighting, Jonathan A. Jarvis, Mikaela J. Dufur, Shana Pribesh

Educational Leadership & Workforce Development Faculty Publications

The purpose of this study is to understand the relationship between family structure and maternal depressive symptoms (MDS) in Australia, the United Kingdom, and the United States. Family structures that involve transitions across life's course, such as divorce, can alter access to resources and introduce new stressors into family systems. Using the stress process model, we examine the links between family structure, stress, resources, and MDS. Using nationally representative data from Australia, the United Kingdom, and the United States and cross-sectional models for each country, we find that family structure may influence MDS differently in the UK than it does …

Identity By Committee, Scott Skinner-Thompson

Publications

Even in school districts with relatively permissive approaches to defining and embodying gender, the identities of transgender and gender variant students are often governed by complex regulatory protocols. Ensuring that a student is able to live their gender at school can involve input from a host of purported stakeholders including medical providers, mental health professionals, school administrators, the student’s parents, and even the broader community. In essence, trans and gender variant students’ identities are governed by committee, which reduces students’ control over their lives, inhibits self-determination, constricts the scope of permissible gender identities, subjects them to incredible degrees of state …