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Articles 31531 - 31560 of 32030
Full-Text Articles in Entire DC Network
Gvsu Undergraduate And Graduate Catalog, 2022-2023, Grand Valley State University
Gvsu Undergraduate And Graduate Catalog, 2022-2023, Grand Valley State University
Course Catalogs, 1963 - Current
Grand Valley State University 2022-2023 undergraduate and graduate course catalog. Course catalogs are published annually to provide students with information and guidance for enrollment.
The Effects Of Fatigue On Landing Impact Forces And Postural Steadiness In Collegiate Volleyball Players, Zebadiah P. Boos
The Effects Of Fatigue On Landing Impact Forces And Postural Steadiness In Collegiate Volleyball Players, Zebadiah P. Boos
Graduate Student Theses, Dissertations, & Professional Papers
Background: The onset of exhaustion can reduce the performance of an athlete and may add to the risk of injury. This establishes the necessity to understand when and how the athlete’s performance is altered as they become fatigued in competition or practice. The aim of this study was to determine the effects of fatigue on dynamic and static tasks in collegiate volleyball athletes by implementing a fatiguing jump protocol. Methods: To replicate an in-game or in-practice situation, five sets of 30 countermovement jumps (CMJ) at 85% maximal height was implemented. Prior to the fatigue protocol, a baseline measure of CMJ …
Evaluating The Use Of Camera Traps To Monitor Populations Of Ungulate Prey In The Russian Far East, Scott Johnston Waller
Evaluating The Use Of Camera Traps To Monitor Populations Of Ungulate Prey In The Russian Far East, Scott Johnston Waller
Graduate Student Theses, Dissertations, & Professional Papers
Efforts to recover endangered carnivore populations are often limited by insufficient populations of prey. When recovering prey populations, estimates of population density are invaluable metrics to monitor recovery efforts. In Russia, wildlife managers use the Formozov-Malyushev-Pereleshin (FMP) snow tracking method to estimate densities of ungulate prey of the Amur tiger (Panthera tigris). Yet, increasing variability in snow conditions and other challenges have limited its reliability. Camera traps offer a promising alternative approach since managers already use cameras to monitor tigers. However, the assumptions and study design necessary to implement capture-recapture models for tigers are different from those needed …
Underwater: Science & Story In Aquatic Communities, Lena J. Beck
Underwater: Science & Story In Aquatic Communities, Lena J. Beck
Graduate Student Theses, Dissertations, & Professional Papers
How do we manage fish species, and how do fish, in turn, impact us? This portfolio of three stories will explore some of the ways in which humans interact with aquatic landscapes. First, we’ll go to Flathead Lake in Montana, where invasive lake trout have all but decimated native trout species, and learn what the Confederated Salish and Kootenai Tribes are doing to address the issue. Then, we’ll examine stories of a legendary Big Fish in Alaska’s Lake Iliamna, and think about what it means to scientifically prove something as real. The last story looks at the aquaculture industry in …
The Combination Of Tlr7/8 And Tlr4 Adjuvants In An Influenza Vaccine Produce Unique Antigen-Specific Adaptive Immunity And Protect Against Lethal Heterologous Influenza Challenge, Shelby Lynn Cole
Graduate Student Theses, Dissertations, & Professional Papers
Influenza virus infection is a global health concern resulting in death and illness each year, which disproportionally effects high-risk individuals. While there are several approved vaccines for seasonal influenza, there are some limitations to consider: current vaccines provide minimal cross protection against seasonally drifted influenza subtypes, influenza vaccine strains change each year, requiring timely manufacture of a new vaccine. Thus, vaccines capable of inducing a more robust and broadly protective immune response to multiple influenza subtypes remains a critical unmet need. Adjuvants and novel delivery systems are an interesting and promising avenue of exploration for enhancing and broadening seasonal influenza …
Egg-Freezing, Uterine Transplants, And In Vitro Gametogenesis: Disruptive Or Normalizing Reproductive Technologies?, Radhika Rao
Egg-Freezing, Uterine Transplants, And In Vitro Gametogenesis: Disruptive Or Normalizing Reproductive Technologies?, Radhika Rao
Faculty Scholarship
In the last year, headlines have heralded the introduction of several radical new technologies that promise to revolutionize procreation and transform our understanding of reproduction. In March 2021, for example, scientists revealed that mouse embryos had been grown in" artificial wombs" for 11 days, roughly half the animal's natural gestation period. According to Jacob Hanna, the biologist at the Weizmann Institute of Science in Israel who led the research team: "This sets the stage for other species. I hope that it will allow scientists to grow human embryos until week five." At the same time, two groups of researchers reported …
The Legacy Of Hurricanes, Historic Land Cover, And Municipal Ordinances On Urban Tree Canopy In Florida (United States), Allyson B. Salisbury, Andrew K. Koeser, Richard J. Hauer, Deborah R. Hilbert, Amr H. Abd-Elrahman, Michael G. Andreu, Katie Britt, Shawn Landry, Mary G. Lusk, Jason W. Miesbauer, Hunter Thorn
The Legacy Of Hurricanes, Historic Land Cover, And Municipal Ordinances On Urban Tree Canopy In Florida (United States), Allyson B. Salisbury, Andrew K. Koeser, Richard J. Hauer, Deborah R. Hilbert, Amr H. Abd-Elrahman, Michael G. Andreu, Katie Britt, Shawn Landry, Mary G. Lusk, Jason W. Miesbauer, Hunter Thorn
School of Geosciences Faculty and Staff Publications
Urban Tree Canopy (UTC) greatly enhances the livability of cities by reducing urban heat buildup, mitigating stormwater runoff, and filtering airborne particulates, among other ecological services. These benefits, combined with the relative ease of measuring tree cover from aerial imagery, have led many cities to adopt management strategies based on UTC goals. In this study, we conducted canopy analyses for 300 cities in Florida to assess the impacts of development practices, urban forest ordinances, and hurricanes on tree cover. Within the cities sampled, UTC ranged from 5.9 to 68.7% with a median canopy coverage of 32.3% Our results indicate that …
P-Adic Analysis: A Quick Introduction, Wilson A. Zuniga-Galindo
P-Adic Analysis: A Quick Introduction, Wilson A. Zuniga-Galindo
School of Mathematical & Statistical Sciences Faculty Publications
These notes aim to provide a fast introduction to p-adic analysis assuming basic knowledge in algebra and analysis. The text corresponds to the lecture notes for a Mini-Course in the L. Santal´o Research Summer School 2019. Palacio de la Magdalena, Santander, Spain, June 24-28, 2019.
Scientific Breakdown Of A Ferromagnetic Nanofluid In Hemodynamics: Enhanced Therapeutic Approach, M. M. Bhatti, Sara Abdelsalam
Scientific Breakdown Of A Ferromagnetic Nanofluid In Hemodynamics: Enhanced Therapeutic Approach, M. M. Bhatti, Sara Abdelsalam
Basic Science Engineering
In this article, we examine the mechanism of cobalt and tantalum nanoparticles through a hybrid fluid model. The nanofluid is propagating through an anisotropically tapered artery with three different configurations; converging, diverging and non-tapered. To examine the rheology of the blood we have incorporated a Williamson fluid model which reveals both Newtonian and non-Newtonian effects. Mathematical and physical formulations are derived using the Lubrication approach for continuity, momentum and energy equations. The impact of magnetic field, porosity and viscous dissipation are also taken into the proposed formulation. A perturbation approach is used to determine the solutions of the formulated nonlinear …
On Behavioral Response Of Ciliated Cervical Canal On The Development Of Electroosmotic Forces In Spermatic Fluid, Sara I. Abdelsalam, A. Z. Zaher
On Behavioral Response Of Ciliated Cervical Canal On The Development Of Electroosmotic Forces In Spermatic Fluid, Sara I. Abdelsalam, A. Z. Zaher
Basic Science Engineering
The goal of this research is to conduct a theoretical investigation about the effect of the electroosmotic forces on the swimming of sperms throughout the cervical canal. To imitate male semen with self-propulsive spermatozoa, a hyperbolic tangent fluid is used as the base liquid. Swimming sperms move inside a ciliated cervical canal and peristalsis occurs due to the ciliated walls. The perturbation method is used to solve the controlling partial differential set of equations analytically. Due to selfpropulsion of swimmers and long wavelength assumption, a creeping flow protocol is used throughout the stream. The stream pattern, velocity distribution, and pressure …
Design Of Educational Material And Public Awareness Campaigns For Improving Work Zone Driver Safety, Ricardo Chahine, Prince Adu Gyamfi, Nandhesh Subash, Wonsang Cho, Krista O. Kelley, Stacey L. Connaughton, Konstantina Gkritza
Design Of Educational Material And Public Awareness Campaigns For Improving Work Zone Driver Safety, Ricardo Chahine, Prince Adu Gyamfi, Nandhesh Subash, Wonsang Cho, Krista O. Kelley, Stacey L. Connaughton, Konstantina Gkritza
JTRP Technical Reports
This project aims to help improve work zone driver safety in Indiana through driver education and public awareness campaigns. The project focused on two specific objectives: (1) to design a public awareness campaign to increase drivers’ knowledge and influence positive attitudes about work zone driver safety practices; and (2) to prepare educational materials to be incorporated into driver’s education or training curriculum prior to taking driving test and getting a driver’s license issued. The campaign was informed by formative research, conducted using a survey to assess public knowledge and attitudes. Based on these results, campaign messages were designed. The team …
The Advocate (Fall 2022), Lewis & Clark Law School
Post-Grant Adjudication Of Drug Patents: Agency And/Or Court?, Arti K. Rai, Saurabh Vishnubhakat, Jorge Lemus, Erik Hovenkamp
Post-Grant Adjudication Of Drug Patents: Agency And/Or Court?, Arti K. Rai, Saurabh Vishnubhakat, Jorge Lemus, Erik Hovenkamp
Faculty Scholarship
The America Invents Act of 2011 (AIA) created a robust administrative system—the Patent Trial and Appeal Board (PTAB)—that provides a route for challenging the validity of granted patents outside of district courts. Congress determined that administrative adjudication of the validity of initial patent grants could be cheaper and more scientifically accurate than district court adjudication of such validity.
For private economic value per patent, few areas of technology can match the biopharmaceutical industry. This is particularly true for small-molecule drugs. A billion-dollar drug monopoly may be protected from competition by a relatively small number of patents. Accordingly, the social cost …
The Law And Science Of Eyewitness Evidence, Thomas D. Albright, Brandon L. Garrett
The Law And Science Of Eyewitness Evidence, Thomas D. Albright, Brandon L. Garrett
Faculty Scholarship
Eyewitness evidence crucially depends on visual perception and memory, which are quite fallible. The potential inaccuracy of eyewitness memory has been long demonstrated in cases of wrongful conviction. Today, decades of scientific research on visual perception and memory have identified key causes of error and methods for improving eyewitness performance. Eyewitness evidence, where identification procedures themselves involve experiments, lends itself to scientific research as do few other areas in law. As a result, eyewitness evidence has become a testing ground for the use of science to inform the law. This Article examines how legal actors—state and federal courts, state lawmakers, …
Jus Sanguinis Or Just Plain Discrimination? Rejecting A Biological Requirement For Birthright Citizenship Of Children Born Abroad To Same-Sex Couples Via Assisted Reproductive Technology, Thomas Evans
Georgia Law Review
Until recently, the State Department had a policy deeming children born abroad to married same-sex couples to be children born out of wedlock. Then, applying the statute for children born out of wedlock with more rigorous requirements, the State Department only allowed citizenship to pass through a biological relationship between the biological parent and the child.
Although the State Department updated this policy in May 2021 to allow for birthright citizenship of children born abroad to married same-sex couples, the new policy does not go far enough. This Note argues that Congress should amend the Immigration and Nationality Act to …
Using Heidisongs Music As An Instructional Tool In The Elementary School Classroom: A Case Study, Leia Denise Jobe
Using Heidisongs Music As An Instructional Tool In The Elementary School Classroom: A Case Study, Leia Denise Jobe
Doctoral Dissertations and Projects
The purpose of this qualitative multiple case study is to understand how teachers use HeidiSongs music as an instructional tool in the elementary school classroom. HeidiSongs uses multisensory structured language education to teach by engaging multiple senses simultaneously to increase retention. The theories guiding this study include Gardner’s theory of multiple intelligences, which involves kinesthetic intelligences among other types of intelligences, and Krashen’s theory of second language acquisition. HeidiSongs uses both musical and kinesthetic activities to enhance literacy. The central research question focused on how teachers use HeidiSongs music as an instructional tool in the elementary school classroom. The sub-questions …
How Utilizing An Online Holistic Social Media Group Impacts Symptoms And Quality Of Life In Individuals With Anxiety, Sherri Ann Walker
How Utilizing An Online Holistic Social Media Group Impacts Symptoms And Quality Of Life In Individuals With Anxiety, Sherri Ann Walker
Doctoral Dissertations and Projects
The continuum between health and illness is a dynamic state influenced by stress. People are complex beings designed with interrelated parts composing a unique whole. Stress's disruption in the homeostatic balance can result in disease states in the body, mind, soul, and relationships. Panic disorder is one of these manifestations. This disorder causes physical and cognitive symptoms which impair quality of life. Although evidence-based treatments exist for panic disorder, barriers are evident for effective dissemination. This phenomenological study explored the experience of six individuals with anxiety disorder in a 30-day holistic, online social media group. Throughout the study, interviews and …
African American Spirituality, Marital Satisfaction, And Internalized Racial Oppression, Tiara Monique Mcintosh
African American Spirituality, Marital Satisfaction, And Internalized Racial Oppression, Tiara Monique Mcintosh
Doctoral Dissertations and Projects
Internalized racism was the topic of the current study. The emphasis of this study was on how African Americans deal with cultural racism and how it impacts their daily lives. One example of early internalized racism is Black teenage girls' dissatisfaction with their skin tones (Pyke, 2010). Internalized racial prejudice manifests itself in the adoption of American ideals of beauty, the devaluation of one's community, and the adoption of unhealthy habits (Campon & Carter, 2015). African Americans are a mixed group of people of many different backgrounds. The historical and contemporary links that link African countries American couples include marital …
Richmond Law Magazine: Winter 2022, University Of Richmond
Richmond Law Magazine: Winter 2022, University Of Richmond
Richmond Law Magazine
Free Britney (and other legal lessons from the headlines)
The Making of a More Perfect Union
Richmond Law: A Story in 7 Objects
Artificial Intelligence (Ai): The New Look Of Customer Service In A Cybersecurity World, Sharon L. Burton
Artificial Intelligence (Ai): The New Look Of Customer Service In A Cybersecurity World, Sharon L. Burton
Publications
Cybersecurity leaders are not adequately developed to guide the re-engineering of quality customer service (QCS) workflows, designed with automation and AI, that interrelate with people through customers’ perceptions. Realizing re-engineering processes should be a team effort with well-versed leadership and stakeholders guiding the successful design through a follow-up process. Leaders must shape compelling and straightforward needs to learn and teach employees and chat boxes indispensable customer service skills demonstrating patience, self-discipline, flexibility, and resourcefulness in communication with irritated customers or difficult circumstances. Whether the analysis, design, development, and implementation struggles are vacuums in cybersecurity knowledge, skill, and abilities or a …
Perhaps It Was Too Soon: College Students' Reflections On The Timing Of Their Sexual Debut., Susan Sprecher, Lucia F O'Sullivan, Michelle Drouin, Julie Verette-Lindenbaum, Marion C Willetts
Perhaps It Was Too Soon: College Students' Reflections On The Timing Of Their Sexual Debut., Susan Sprecher, Lucia F O'Sullivan, Michelle Drouin, Julie Verette-Lindenbaum, Marion C Willetts
Health Services and Informatics Research
Early sexual debut has been a focus of social scientific research due to its association with adverse circumstances and negative outcomes. However, there has been a recent shift to considering not only chronological age, but also the degree to which the event is viewed to be optimally timed (i.e., the perception that it occurred at the "right time" versus too soon). The purpose of this study was to assess how individual/family background variables and contextual aspects of the experience (including partner and relationship aspects) are associated with both the actual age at sexual debut and the perceived acceptability of the …
Exercise In Advanced Prostate Cancer Elevates Myokine Levels And Suppresses In-Vitro Cell Growth, Jin Soo Kim, Dennis R. Taaffe, Daniel A. Galvão, Nicolas H. Hart, Elin Gray, Charles J. Ryan, Stacey A. Kenfield, Fred Saad, Robert U. Newton
Exercise In Advanced Prostate Cancer Elevates Myokine Levels And Suppresses In-Vitro Cell Growth, Jin Soo Kim, Dennis R. Taaffe, Daniel A. Galvão, Nicolas H. Hart, Elin Gray, Charles J. Ryan, Stacey A. Kenfield, Fred Saad, Robert U. Newton
Research outputs 2022 to 2026
Background:
Altering the systemic milieu through exercise has been proposed as a potential mechanism underlying exercise-driven tumour suppression. It is not yet known whether men with advanced prostate cancer can elicit such adaptations following a program of exercise. The purpose is to examine myokine levels of serum acquired from metastatic castrate-resistant prostate cancer (mCRPC) patients recruited to the INTERVAL-GAP4 trial before and after 6 months of exercise and its tumour-suppressive effect.
Methods:
Twenty-five men with mCRPC (age = 74.7 ± 7.1 yrs) were randomised to supervised multimodal (aerobic and resistance) exercise (EX) or self-directed exercise control group (CON). Body composition …
Do Bird Communities Differ With Post-Fire Age In Banksia Woodlands Of South-Western Australia?, Robert A. Davis, Leonie E. Valentine, Michael D. Craig
Do Bird Communities Differ With Post-Fire Age In Banksia Woodlands Of South-Western Australia?, Robert A. Davis, Leonie E. Valentine, Michael D. Craig
Research outputs 2022 to 2026
Prescribed fire is a widespread management practice in fire-prone ecosystems that can have significant effects on fauna. To inform the development of appropriate prescribed burning regimes, we explored bird responses to time since fire in threatened Banksia woodlands in south-western Australia. We used area searches to estimate bird densities on 20 plots ranging from 1 to 26 years post fire. Fire had no significant effect on the overall bird community or any foraging guilds and there was no clear post-fire succession. Of the 26 frequently occurring species analysed, only two showed responses to fire, with yellow-rumped thornbills more abundant in …
Nationwide Industry-Led Community Exercise Program For Men With Locally Advanced, Relapsed, Or Metastatic Prostate Cancer On Androgen-Deprivation Therapy, Oliver Schumacher, Daniel A. Galvao, Dennis R. Taaffe, Nigel Spry, Dickon Hayne, Colin Tang, Raphael Chee, Robert U. Newton
Nationwide Industry-Led Community Exercise Program For Men With Locally Advanced, Relapsed, Or Metastatic Prostate Cancer On Androgen-Deprivation Therapy, Oliver Schumacher, Daniel A. Galvao, Dennis R. Taaffe, Nigel Spry, Dickon Hayne, Colin Tang, Raphael Chee, Robert U. Newton
Research outputs 2022 to 2026
Purpose:
Androgen-deprivation therapy in patients with prostate cancer (PCa) is associated with considerable side effects and secondary comorbidities such as overweight/obesity and cardiovascular disease. The aim of this study was to investigate the effectiveness of an industry-led, treatment-integrated, community-based exercise program on outcomes of body weight, cardiovascular health, and physical function.
Patients and Methods:
PCa patients with locally advanced, relapsed, or metastatic disease receiving leuprorelin acetate were enrolled across multiple sites in Australia and assigned supervised group exercise undertaken weekly or biweekly (ie, 16 exercise sessions in total) for 10-18 weeks, consisting of aerobic and resistance training performed at moderate-to-vigorous …
Cphelps Et Al. Disease, Natural And Aquaria E. Radiata Microbiome Asv (Amplicon Sequence Variant) Table, Charlie M. Phelps
Cphelps Et Al. Disease, Natural And Aquaria E. Radiata Microbiome Asv (Amplicon Sequence Variant) Table, Charlie M. Phelps
Research Datasets
This ASV table is the raw sequencing abundances for the Chapter 4 dataset with accompanying metadata.
Ancestral Sars-Cov-2, But Not Omicron, Replicates Less Efficiently In Primary Pediatric Nasal Epithelial Cells, Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C. Karawita, Georgina Mccallum, Lauren E. Steele, Ayaho Yamamoto, Larisa I. Labzin, Tejasri Yarlagadda, Alexander A. Khromykh, Xiaohui Wang, Julian D. J. Sng, Claudia J. Stocks, Yao Xia, Tobias R. Kollmann, David Martino, Merja Joensuu, Frédéric A. Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, Asha C. Bowen, Anthony Kicic, Peter D. Sly, Kirsten M. Spann, Kirsty R. Short
Ancestral Sars-Cov-2, But Not Omicron, Replicates Less Efficiently In Primary Pediatric Nasal Epithelial Cells, Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C. Karawita, Georgina Mccallum, Lauren E. Steele, Ayaho Yamamoto, Larisa I. Labzin, Tejasri Yarlagadda, Alexander A. Khromykh, Xiaohui Wang, Julian D. J. Sng, Claudia J. Stocks, Yao Xia, Tobias R. Kollmann, David Martino, Merja Joensuu, Frédéric A. Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, Asha C. Bowen, Anthony Kicic, Peter D. Sly, Kirsten M. Spann, Kirsty R. Short
Research outputs 2022 to 2026
Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. However, the emergence of SARS-CoV-2 variants of concern (VOCs) has been associated with an increased number of pediatric infections. Whether this is the result of widespread adult vaccination or fundamental changes in the biology of SARS-CoV-2 remain to be determined. Here, we use primary nasal epithelial cells (NECs) from children and adults, differentiated at an air-liquid interface to …
Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming
Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming
Research outputs 2022 to 2026
Bioturbation by digging animals is important for key forest ecosystem processes such as soil turnover, decomposition, nutrient cycling, water infiltration, seedling recruitment, and fungal dispersal. Despite their widespread geographic range, little is known about the role of the short-beaked echidna (Tachyglossus aculeatus) in forest ecosystems. We measured the density and size of echidna diggings in the Northern Jarrah Forest, south-western Australia, to quantify the contribution echidna make to soil turnover. We recorded an overall density of 298 echidna diggings per hectare, 21 % of which were estimated to be less than 1 month old. The average size of digs was …
Editorial: Fire Regimes In Desert Ecosystems: Drivers, Impacts And Changes, Eddie J. B. Van Etten, Matthew L. Brooks, Aaron C. Greenville, Glenda M. Wardle
Editorial: Fire Regimes In Desert Ecosystems: Drivers, Impacts And Changes, Eddie J. B. Van Etten, Matthew L. Brooks, Aaron C. Greenville, Glenda M. Wardle
Research outputs 2022 to 2026
Although not commonly associated with fire, many desert ecosystems across the globe do occasionally burn, and there is evidence that fire incidences are increasing, leading to altered fire regimes in this biome. The increased prevalence of megafires (wildfires > 10,000 ha in size and typically damaging) in most global biomes is linked to climate change, although those occurring in deserts have received far less attention, from both a research and policy perspective, than that of forested ecosystems (Linley et al., 2022). Understanding the drivers of desert fires, from climate to landscape patterns of hydrology and soil, and how these may be …
Identification Of Leukocyte Surface P2x7 As A Biomarker Associated With Alzheimer's Disease, Yihan Li, Xin Huang, Christopher Fowler, Yen Y. Lim, Simon M. Laws, Noel Faux, James D. Doecke, Brett Trounson, Kelly Pertile, Rebecca Rumble, Vincent Doré, Victor L. Villemagne, Christopher C. Rowe, James S. Wiley, Paul Maruff, Colin L. Masters, Ben J. Gu
Identification Of Leukocyte Surface P2x7 As A Biomarker Associated With Alzheimer's Disease, Yihan Li, Xin Huang, Christopher Fowler, Yen Y. Lim, Simon M. Laws, Noel Faux, James D. Doecke, Brett Trounson, Kelly Pertile, Rebecca Rumble, Vincent Doré, Victor L. Villemagne, Christopher C. Rowe, James S. Wiley, Paul Maruff, Colin L. Masters, Ben J. Gu
Research outputs 2022 to 2026
Alzheimer's disease (AD) has shown altered immune responses in the periphery. We studied P2X7 (a proinflammatory receptor and a scavenger receptor) and two integrins, CD11b and CD11c, on the surface of circulating leukocytes and analysed their associations with Aβ-PET, brain atrophy, neuropsychological assessments, and cerebrospinal fluid (CSF) biomarkers. Total 287 age-matched, sex-balanced participants were recruited in a discovery cohort and two validation cohorts through the AIBL study and studied using tri-colour flow cytometry. Our results demonstrated reduced expressions of P2X7, CD11b, and CD11c on leukocytes, particularly monocytes, in Aβ +ve cases compared with Aβ -ve controls. P2X7 and integrin downregulation …
Polygenic Resilience Scores Capture Protective Genetic Effects For Alzheimer’S Disease, Jiahui Hou, Jonathan L. Hess, Nicola Armstrong, Joshua C. Bis, Benjamin Grenier-Boley, Ida K. Karlsson, Ganna Leonenko, Katya Numbers, Eleanor K. O’Brien, Alexey Shadrin, Anbupalam Thalamuthu, Qiong Yang, Ole A. Andreassen, Henry Brodaty, Margaret Gatz, Nicole A. Kochan, Jean Charles Lambert, Simon M. Laws, Colin L. Masters, Karen A. Mather, Nancy L. Pedersen, Danielle Posthuma, Perminder S. Sachdev, Julie Williams, Alzheimer’S Disease Neuroimaging Initiative, Chun Chieh Fan, Stephen V. Faraone, Christine Fennema-Notestine, Shu-Ju Lin, Valentina Escott-Price, Peter Holmans, Sudha Seshadri, Ming T. Tsuang, William S. Kremen, Stephen J. Glatt
Polygenic Resilience Scores Capture Protective Genetic Effects For Alzheimer’S Disease, Jiahui Hou, Jonathan L. Hess, Nicola Armstrong, Joshua C. Bis, Benjamin Grenier-Boley, Ida K. Karlsson, Ganna Leonenko, Katya Numbers, Eleanor K. O’Brien, Alexey Shadrin, Anbupalam Thalamuthu, Qiong Yang, Ole A. Andreassen, Henry Brodaty, Margaret Gatz, Nicole A. Kochan, Jean Charles Lambert, Simon M. Laws, Colin L. Masters, Karen A. Mather, Nancy L. Pedersen, Danielle Posthuma, Perminder S. Sachdev, Julie Williams, Alzheimer’S Disease Neuroimaging Initiative, Chun Chieh Fan, Stephen V. Faraone, Christine Fennema-Notestine, Shu-Ju Lin, Valentina Escott-Price, Peter Holmans, Sudha Seshadri, Ming T. Tsuang, William S. Kremen, Stephen J. Glatt
Research outputs 2022 to 2026
Polygenic risk scores (PRSs) can boost risk prediction in late-onset Alzheimer’s disease (LOAD) beyond apolipoprotein E (APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-conferring common genetic variants in (1) unaffected individuals having high PRSs for LOAD, and (2) unaffected APOE-ε4 carriers also having high PRSs for LOAD. We used genome-wide association study (GWAS) to contrast “resilient” unaffected individuals at the highest genetic risk for LOAD with LOAD cases at comparable risk. From GWAS results, we constructed polygenic resilience scores to aggregate the addictive contributions of risk-orthogonal common variants that promote resilience …