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Versatile Functionalization Strategy For The Capture Of Antibodies Using Silica Nanoparticles, Sayma Afrin

Theses and Dissertations--Chemical and Materials Engineering

In this work, the synthesis of protein-functionalized nonporous silica nanoparticles and their application to capture antibodies was demonstrated. Silica nanoparticles were chosen as they offered particle and pore size tunability, low toxicity, thermal stability, ease of synthesis and ease of surface functionalization. A biotin-streptavidin-biotin bridge was constructed on the surface of the particles and used to attach biotinylated Protein A/G (PAG), which has high affinity for antibodies. The biotin-streptavidin-biotin bridge is hypothesized to orient the PAG in a favorable manner for efficient antibody capture. Nonporous silica nanoparticles (approximately 270 nm in diameter) were synthesized via the Stöber method. Following amine …

Contributors - Quaker Religious Thought, No. 138, Jon R. Kershner

Quaker Religious Thought

No abstract provided.

Further Validation Of The Perceptions Of Uncertainties In Genome Sequencing Scale Among Patients With Cancer Undergoing Tumor Sequencing, Kendall L. Umstead, Rachel Campbell, Christine E. Napier, Nicole Bartley, Megan C. Best, Phyllis N. Butow, Barbara B. Biesecker

IES Papers and Journal Articles

It is important to understand how individuals perceive uncertainties and the consequent impact on their psychological well-being and health behavior. The Perceptions of Uncertainties in Genome Sequencing (PUGS) scale measures clinical, affective, and evaluative uncertainties about information from sequencing. The PUGS scale has been shown to be valid and reliable among individuals receiving results about their genomes. This study assessed whether its validity generalized to patients with cancer undergoing tumor sequencing. Exploratory factor analysis (EFA) was conducted on data from the Molecular Screening and Therapeutics Program (n = 310) to identify a measurement model. Confirmatory factor analysis (CFA) was …

Psychological Outcomes In Advanced Cancer Patients After Receiving Genomic Tumor Profiling Results, Sabina Vatter, Timothy E. Schlub, Christine E. Napier, Megan C. Best, Nicci Bartley, Ilona Juraskova, Bettina Meiser, Mandy L. Ballinger, Barbara B. Biesecker, David Goldstein, David M. Thomas, Phyllis Butow, Members Of The Pigeon Project

IES Papers and Journal Articles

Background: Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depression, and CGP-specific anxiety in advanced cancer patients after receiving CGP results and 2–3months later.

Method: Participants were enrolled in a longitudinal psychosocial substudy, embedded in the Molecular Screening and Therapeutics Program, and had advanced solid cancers of any histological type with sufficient and accessible tissue for CGP. At T0 (before receiving CGP results), 1,431 participants completed sociodemographic, disease …

Honoring The Public Trust: Curbing The Bane Of Physician Sexual Misconduct, Rebecca H. Allensworth, K. S. Sindhu, Et Al.

Vanderbilt Law School Faculty Publications

The Federation of State Medical Boards defines physician sexual misconduct as any "behavior that exploits the physician-patient relationship in a sexual way." Although several attempts have been made in recent years to clarify its incidence in the United States, physician sexual misconduct is almost certainly underreported. Physician sexual misconduct represents a severe and irreversible violation of the compact underlying the patient–physician relationship and can have far-reaching consequences on the lives of patients and their families. In addition, the credibility of and trust in physicians, both essential to the provision of medical care, could well erode in the eyes of the …

What Property Does, Christopher Serkin

Vanderbilt Law School Faculty Publications

For centuries, scholars have wrestled with seemingly intractable problems about the nature of property. This Article offers a different approach. Instead of asking what property is, it asks what property does. And it argues that property protects people’s reliance on resources by moderating the pace of change. Modern scholarly accounts emphasize voluntary transactions as the source and purpose of reliance in property. Such “transactional reliance” implies strong, stable, and enduring rights. This Article argues that property law also reflects a very different source of reliance on resources, one that rises and falls simply with the passage of time. This new …

Agile Course Design: Modeling Flexibility, Empowering Engagement, And Prioritizing Community, Julie A. Rowan, Todd A. Stanislav, Allison C. Bernknopf, Tracy E. Russo

Pedagogicon Conference Proceedings

The Agile Course Design Institute, created for faculty at a regional public university, utilized an agile thinking lens to model flexible, interactive learning. The Institute framework consisted of three core factors: sense of belonging, students’ bandwidth, and interaction and engagement. Faculty participated in online synchronous and asynchronous settings to develop agile courses. In doing so, they gained insights into the experiences their students might have in remote learning. Examples from the Institute and participant work are explored through a “Why” (purpose/outcome), “What” (connections to the ACDI framework), and “How” (tools and strategies) structure.

Pornography A Public Health Crisis In Utah, Candace A. Green

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: The goal is to reduce Utah’s teenage pornography consumption by 25% through the implementation of an in-home program where parents and guardians can learn communication skills, teach their children about the risk factors and dangers of pornography addiction, and apply prevention strategies and protective measures in their own home.

Significant Findings: Pornography use is more prevalent now than at any other time in history. Much of this can be attributed to our cell phones and the 24-hour internet access we have at our fingertips which makes viewing sexually explicit material a few seconds away at all times. Utah …

Increase Awareness Of Adolescent Depression And Suicidal Ideations In Orleans County, Vermont, Nicole Corbett

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: Collaborate with Vermont SPC and NAMI chapter of Vermont as well as school behavior team and school-based clinicians to implement a mental health /suicide prevention program for the local middle school and high school to be implemented during the 2022-2023 school year with a minimum of four contacts/events.

Significant Findings: This social change portfolio was developed to increase awareness of the mental health needs of adolescents in Orleans County, Vermont, and to investigate the next steps in building a prevention program to support this population. Adolescent depression and suicidal ideation affect the lives of over a quarter of …

Hiv/Aids Community Awareness And Prevention In Atlanta, Georgia, Marytherese Agwara

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: To discuss HIV/AIDS awareness and preventive measures that may aid in mitigating the disease, and suggest ways for advocacy. Significant Findings: The prevalence of HIV/AIDS continues to be on the rise in Metro Atlanta areas with the black men who have sex with men (MSM) being disproportionately affected. Findings indicated that the black MSM were mostly affected due to great number of them praticicng same sex act (Hicks, 2017). Subsequent finding showed that the high prevalence was due to unprotected sex, substance and alcohol abuse, and mental health issues (Pérez et al., 2018). Collaborative efforts from governmental and …

The Law And Gospel Of Human Rights And Duties: John Paul Ii And Michael Perry On Sacredness And Intentional Killing, Timothy P. Jackson

Emory Law Journal

No abstract provided.

Biofabrication Of Magnetic Nanoparticles And Their Use As Carriers For Pectinase And Xylanase, Shady S. Hassan, Brendan Duffy, Gwilym A. Williams, Amit Jaiswal

Articles

In this study, superparamagnetic iron oxide nanoparticles (MNPs) were synthesized via exposure of fungal cell filtrate from Aspergillus flavus to aqueous iron ions. The extracellular synthesis of MNPs was monitored by UV–Vis spectrophotometry and showed an absorption peak at 310 nm. The morphology of MNPs was found to be flake-like, as confirmed by Field Emission Scanning Electron Microscopy (FESEM), while the average crystallite size was ∼16 nm, as determined by X-ray diffraction (XRD). Energy dispersive X-ray (EDX) analysis was performed to confirm the presence of elemental Fe in the sample. Pectinase and xylanase were covalently immobilized on MNPs with efficiencies …

Attainable Moment Set And Actuation Time Of A Bio-Inspired Rotating Empennage, Christian R. Bolander, Douglas F. Hunsaker, David Myszka, James J. Joo

Mechanical and Aerospace Engineering Faculty Publications

Future tactical aircraft will likely demonstrate improvements in efficiency, weight, and control by implementing bio-inspired control systems. This work analyzes a novel control system for a fighter aircraft inspired by the function of – and the degrees of freedom available in – a bird’s tail. The control system is introduced to an existing fighter aircraft design by removing the vertical tail and allowing the horizontal tail surfaces to rotate about the roll axis. Using a low-fidelity aerodynamic model, an analysis on the available controlling moments and actuation speeds of the baseline aircraft is compared to that of the bio-inspired rotating …

International Environmental Law At Its Semicentennial: The Stockholm Legacy, Melissa (M.J.) Durkee

Scholarship@WashULaw

The 1972 United Nations Conference on the Human Environment produced the Stockholm Declaration, an environmental manifesto that forcefully declared a human right to environmental health and birthed the field of modern international environmental law. The historic event powerfully “dramatized . . . the unity and fragility of the biosphere,” sparking a remarkable period of international legal innovation and cooperation on environmental protection in the decades to come.

The Stockholm Declaration can be rightly celebrated for putting environmental issues on the international legal agenda and driving the development of environmental law at the domestic level around the world. At the same …

Me-Em Enewsbrief, December 2021, Department Of Mechanical Engineering-Engineering Mechanics, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.

Fertility Fraud: The Child's Claims Essays, Fredrick Vars

Articles

No abstract provided.

Biom/Biol 4110: The Science Of Medicine (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Integration of fundamental principles from physics, chemistry, biology and mathematics, and applications of these principles to solve problems in medicine.

Biom 4906: Tissue Engineering (Syllabus), Gary L. Bowlin

Biomedical Engineering Syllabi Archive

Course Description: To study the design, development, and implantation of tissue engineered components. Analysis of the basis for cell growth and differentiation, control of tissue development (in vivo & in vitro), models for tissue engineering, and transplantation of engineered cells and tissues. The emphasis of these analyses will be focused on the cardiovascular system (blood vessels and cardiac prostheses), musculoskeletal system (Bone, cartilage, and tendons), and skin.

Biom 4801/6801: Introduction To Medical Imaging (Syllabus), Aaryani Sajja

Biomedical Engineering Syllabi Archive

Course Description: This course will introduce fundamentals of the four most-important clinical medical imaging modalities: X-ray, Radionuclide, Ultrasound, and MRI. The primary focus is on the physical principles, instrumentation methods, imaging algorithms, and clinical applications of each imaging modality.

Mechanism And Methods Of Early Prevention Of Bank Insolvency, Morgan Alexander Fox

DLSU Business & Economics Review

Early detection of the financial condition of commercial banks is especially relevant in modern conditions of economic turbulence related to the global COVID-19 pandemic. The article provides a brief overview of the applied methods in the early detection of financial problems and prevention of bank insolvency. This study also explains the use and purpose of systems such as CAMELS and multivariate analysis models.The article illustrates the necessity of the complex use of multivariate analysis models and averaging simulation results in obtaining the most reliable results.A mechanism is offered for organizing the process of early prevention of bank insolvency.When implementing this …

2022 Georgia Southern University Men's Soccer Roster, Georgia Southern University

Men's Soccer Records

• Georgia Southern University Athletics 2022 Men's Soccer Roster

2022 Georgia Southern University Women's Soccer Media Guide, Georgia Southern University

Women's Soccer Records

No abstract provided.

Investigation Of A Carbon Monoxide Dehydrogenase From An Uncultured Archaeon, Luke Moore

Dissertations, Master's Theses and Master's Reports

The Nickel based Carbon Monoxide Dehydrogenase (CODH) is an anaerobic metalloenzyme responsible for the reversible conversion of CO and water into CO2 and 2 protons and 2 electrons. This enzyme has importance in the environment as one of Earth’s first carbon fixation pathways, and for human uses as a potential source of biofuels and other commodity chemicals. CODH enzymes are present in a wide array of taxa, many of which are uncultured. In this study we express and purify the catalytic subunit (CooS) of the anaerobic CODH from an uncultured Hydrothermarchaeota JdFR-17 co-expressed with the nickel insertion accessory protein (CooC) …

Trophic Ecology And Mercury Bioaccumulation Among Lake Superior Lake Trout Ecotypes, Dalton C. Norris

Dissertations, Master's Theses and Master's Reports

The Lake Superior lake trout population consists of siscowet, lean, humper and redfin ecological morphotypes or ‘ecotypes’. In addition to morphological differences, these ecotypes occupy different habitats in Lake Superior and partition various invertebrate and fish prey resources. In this study, I measured the stable isotopes of carbon (δ¹³C) and nitrogen (δ¹⁵N) and mercury concentrations among these ecotypes collected from Lake Superior waters surrounding Isle Royale. Average mercury concentrations were highest for redfins (1389 ng/g dry wt) followed by siscowets (823 ng/g), humpers (799 ng/g) and leans (519 ng/g) and differed significantly among the ecotypes ( …

The Lives Of Late Soviet Science, 1945-1991, Grégory Dufaud, Ksenia Tatarchenko

Research Collection College of Integrative Studies

This study explores the multifaceted landscape of Soviet science from the end of World War II to the dissolution of the USSR in 1991. It examines the interplay between scientific innovation and political ideology, highlighting how the state shaped research agendas and scientific practices during a period marked by both significant achievements and profound challenges. Through an analysis of key scientific institutions, prominent figures, and pivotal projects, the study illustrates the tensions between ideological constraints and the pursuit of knowledge. Additionally, it addresses the impacts of international collaboration and competition during the Cold War, revealing how these dynamics influenced scientific …

The Pathology Of Ideology: Authoritarian Leadership In Science Fiction Film, Kimberly Yost

Interdisciplinary Journal of Leadership Studies

This article explores ways in which selected science fiction visual narratives depict white male privilege as a pathology affecting social systems and how those who are marginalized, oppressed, and traumatized in these dystopic social systems choose violence to overcome the authoritarian leaders.

An Emerging Masculinity: A Qualitative Study Of Majority-Status Men's Gender Socialization, Emily Sargent

Antioch University Dissertations & Theses

Majority-status American men have been found to disproportionately experience suicide, homicide, perpetration of sexual assault and intimate partner violence, as well as, alcohol and drug-related concerns. Current research considers gender socialization of traditional constructs of masculinity to be “toxic” for men and others (i.e., Women, gender and sexual minorities). This study sought to explore young men’s current experience of masculinity identity development in America. Six participants who self-identified as White, straight, English speaking, educated, cisgender, and emerging adult men shared their lived experience of masculinity via virtual video interviews. To assess results of this qualitative study, interpretive phenomenological analysis was …

Mapping Quantitative Trait Loci And Developing First Molecular Marker For Race 5 Of Podosphera Xanthii Resistance In Melon (Cucumis Melo L.), Abdullah Ünlü, İlknur Polat, Aytül Yildirim, Ahmet Naci̇ Onus

Turkish Journal of Botany

Powdery mildew of melon caused by the Podosphaera xanthii factor is a disease that causes serious yield losses economically in all areas where melon is grown from Asia to Europe and America. The use of resistant varieties for the control of the disease is the most environmentally friendly method. However, traditional methods of melon breeding have made a noteworthy input to resistance varieties improvement, but they have been slow and incompetent in targeting complex powdery mildew disease resistance traits. To overcome these problems and to facilitate breeding programs, molecular markers closely linked to the Pm-R5 gene are needed for marker-assisted …

The Chromosomal Evolution And Analyses Of Turkish Cousinia Species, Tuna Uysal, Osman Tugay, Kuddi̇si̇ Ertuğrul, Meryem Bozkurt, Deni̇z Ulukuş, Hakki Demi̇relma

Turkish Journal of Botany

In this study, Turkish Cousinia species were examined in point of chromosome number and morphology. To our knowledge, this work is the first comprehensive chromosomal study regarding Turkish Cousinia as a whole, especially for endemics. As consistent with previous reports, the chromosome numbers are mostly 2n = 26 and have been determined also as 2n = 24 for only the members of Cynaroideae and Sphaerocephalae sections. An interesting result of this paper is that there is not any polyploid species in this taxonomic group and all of them are diploids. Concerning the chromosome evolution of the Cousinia species, we concluded …

Molecular Analysis Of The Section Sphagnum (Sphagnaceae): First Study On Turkish Bryophytes Using Nucleotide Sequences Of The Trnl Intron Region, Mesut Kirmaci, Asli Semi̇z, Adi̇le Sari, Özden Özgün Acar, Uğur Çatak, Fulya Fi̇li̇z

Turkish Journal of Botany

The genus Sphagnum is one of the richest taxa among the Turkish bryophytes. Up to now, it has been represented by 27 taxa in six sections (Sphagnum, Acutifolia, Squarrosa, Subsecunda, Cuspidata, and Rigida). In this study, an identification key for the section Sphagnum was prepared, and the section was investigated using phylogenetic analyses, with a main focus on Turkish bryophytes. This study provides the first sequence data of the trnL intron region for five species of the section Sphagnum from Turkey (namely S. centrale, S. divinum, S. medium, S. palustre, and S. papillosum) to be used in future studies and …