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Articles 29371 - 29400 of 32035
Full-Text Articles in Entire DC Network
Rancher Perspectives On Livelihood Diversification Options In Montana's Blackfoot River Watershed, Sara N. Schmidt
Rancher Perspectives On Livelihood Diversification Options In Montana's Blackfoot River Watershed, Sara N. Schmidt
Graduate Student Theses, Dissertations, & Professional Papers
The Blackfoot River watershed in Western Montana, like many rural landscapes across the Intermountain West, has faced a suite of economic, demographic, and social change over the last 40 years. Cattle ranching specifically, a principal land use in the Blackfoot watershed, has faced increasing socioeconomic challenges due to global competition, falling cattle prices, amenity migration, and climate change. Ranch livelihood diversification presents an opportunity to bolster the profitability of ranches in the watershed, while also supporting the well-being of rural communities and conserving the intact, ecologically-significant rangelands upon which ranching depends. The Blackfoot Challenge (BC) is a nonprofit community-based conservation …
The Mountain Home: Spatial And Optimal Foraging Assessments Of Hunter- Gatherer Mountain Landscape Use In The Beartooth Mountains, Montana, Scott William Dersam
The Mountain Home: Spatial And Optimal Foraging Assessments Of Hunter- Gatherer Mountain Landscape Use In The Beartooth Mountains, Montana, Scott William Dersam
Graduate Student Theses, Dissertations, & Professional Papers
Patterns of cultural mountain adaptations are recorded throughout the Western Cordillera of North America. They demonstrate prolonged and complex uses of these ecosystems over the Holocene. What behaviors or circumstances in the Early Holocene transitioned mountains from inhospitable to reliable territory? This research addresses this question in the Beartooth Mountains of the Greater Yellowstone Ecosystem (GYE).
Foraging behaviors dictate hunter-gatherer mobility and habitation patterning. These behaviors are reflected in the spatial arrangement of archaeological activity areas and lithic tools in mountainous ecosystems. Energy-demanding ecosystems, require foraging behaviors and habitation strategies that conserve energy. I assert that to understand the emergence …
Body Temperature And Reproductive Effort In A Long-Lived Tropical Songbird, Holly R. Jackson
Body Temperature And Reproductive Effort In A Long-Lived Tropical Songbird, Holly R. Jackson
Graduate Student Theses, Dissertations, & Professional Papers
Heat production relative to dissipation rates have constrained reproductive effort and reduced fitness in short-lived, temperate birds. To determine whether heat constrains reproductive effort in long-lived taxa with low reproductive effort, we experimentally clipped plumage from tropical Gray-throated babblers (Stachyris nigriceps) to increase heat dissipation rates. Contrary to findings in short-lived species, we found no strong evidence of heat dissipation constraints on reproductive effort in our mid-elevation study. Clipped adults did not increase feeding rates compared to controls, but clipped females did spend more time incubating and brooding eggs and young. Increased time in the nest may reduce increased heat …
Longitudinal Patterns Of Microplastic Abundance And Potential For Food Web Uptake In The Yakima River, Janell Shah
Longitudinal Patterns Of Microplastic Abundance And Potential For Food Web Uptake In The Yakima River, Janell Shah
All Master's Theses
Microplastic (MP) pollutes environments worldwide, but the ecological consequences remain largely unknown. While MP research has historically focused on marine environments, recent work has increasingly investigated rivers as transporters of MP from terrestrial sources to the ocean. Some studies have documented instances of MP consumption in a river food web, but few have investigated multiple consumers at different points along a river continuum. This study enumerated the MP abundance in the water column, biofilm, and four macroinvertebrate families from different functional feeding groups across nine sites spanning 344 kilometers from the headwaters to the mouth of the Yakima River in …
Instrumental And Emotional Social Support Intention And Utilization Among Pregnant And Postpartum Women During The Covid-19 Pandemic, Gracie Minks
All Master's Theses
Postpartum depression impacts 1 in 7 women across the U.S. As a whole population, between 10-16% of women are impacted by maternal depression during pregnancy or the first year postpartum. Those who experience postpartum depression are at risk for repeated depressive episodes and a lower quality of life over time. The postnatal period may reflect the most vulnerable time for mental health concerns such as anxiety and depression. Fear, judgment, and perceived criticism are commonly named as barriers that delay the mobilization of support.
There is a prevailing perception that postpartum depression is a normal part of motherhood which may …
Battle Of The Sexes: Similarities And Differences In Lay People’S Perceptions About Male And Female Sex Offenders, Felix O. Osagie Jr., Emily Pica
Battle Of The Sexes: Similarities And Differences In Lay People’S Perceptions About Male And Female Sex Offenders, Felix O. Osagie Jr., Emily Pica
Modern Psychological Studies
The aim of this research was to examine public perceptions about male and female sex offenders to help address gender disparities that exist in the justice system and society. Participants (N = 226) completed the revised Community Attitudes Towards Sex Offenders Scale (ATS; Harper & Hogue, 2015) and a questionnaire concerning opinions about female sex offenders. While there were no observed differences in perceptions between gender overall, differences emerged when examining only parents. Parents perceived male sex offenders worse than female sex offenders. This study also brings awareness to gender bias regarding male and female sex offenders. The implication of …
Nbp 2.0: Updated Next Bar Predictor, An Improved Algorithmic Music Generator, Belinda M. Dungan, Proceso L. Fernandez Jr
Nbp 2.0: Updated Next Bar Predictor, An Improved Algorithmic Music Generator, Belinda M. Dungan, Proceso L. Fernandez Jr
Electronics, Computer, and Communications Engineering Faculty Publications
Deep neural network advancements have enabled machines to produce melodies emulating human-composed music. However, the implementation of such machines is costly in terms of resources. In this paper, we present NBP 2.0, a refinement of the previous model next bar predictor (NBP) with two notable improvements: first, transforming each training instance to anchor all the notes to its musical scale, and second, changing the model architecture itself. NBP 2.0 maintained its straightforward and lightweight implementation, which is an advantage over the baseline models. Improvements were assessed using quantitative and qualitative metrics and, based on the results, the improvements from these …
Longitudinal Clustering Of Health Behaviors Within The Framingham Heart Study, Nathan L. Baumann
Longitudinal Clustering Of Health Behaviors Within The Framingham Heart Study, Nathan L. Baumann
Open Access Dissertations
Health risk behaviors (HRB) have been shown to impact non-communicable chronic disease (NCI) over the lifespan, which are among the leading causes of mortality within the United States. Treatment of NCI includes both pharmacological and behavior change intervention. Though behavior change recommendations are common in the treatment of NCI, our understanding of the long-term trajectory of HRB and how they cluster are not yet fully understood. The current study seeks to elucidate the clustering of specific health behavior changes over the lifespan, bolstering the potential for taking preventative measures as well as fostering positive health behavior change more broadly in …
Effect Of Care Environment On Educational Attainment Among Orphaned And Separated Children And Adolescents In Western Kenya, Dorothy Apedaile, Allison Delong, Edwin Sang, David Ayuku, Lukoye Atwoli, Omar Galárraga, Paula Braitstein
Effect Of Care Environment On Educational Attainment Among Orphaned And Separated Children And Adolescents In Western Kenya, Dorothy Apedaile, Allison Delong, Edwin Sang, David Ayuku, Lukoye Atwoli, Omar Galárraga, Paula Braitstein
Internal Medicine, East Africa
Background: There are approximately 140 million orphaned and separated children (OSCA) around the world. In Kenya, many of these children live with extended family while others live in institutions. Despite evidence that orphans are less likely to be enrolled in school than non-orphans, there is little evidence regarding the role of care environment. This evidence is vital for designing programs and policies that promote access to education for orphans, which is not only their human right but also an important social determinant of health. The purpose of this study was to compare educational attainment among OSCA living in Charitable …
What's Wrong With The Ncaa's New Transgender Athlete Policy?, Erin E. Buzuvis
What's Wrong With The Ncaa's New Transgender Athlete Policy?, Erin E. Buzuvis
Faculty Scholarship
This Article examines the NCAA’s 2022 transgender athlete participation policy, which replaced the 2011 uniform eligibility rule with a sport-by-sport approach deferring to external governing bodies. It assesses the ambiguities created by this deference, particularly in sports where no clear policy exists, as well as the arbitrariness of the default testosterone threshold the NCAA adopted. It analyzes the tension between the NCAA’s stated alignment with Olympic frameworks and the reality that those frameworks were not designed for the collegiate context. It also considers the legal risks posed to NCAA member institutions, including potential liability under Title IX and the Equal …
Women's Empowerment Through The Use Of Technology, Wolayat Tabasum Niroo, Helen Crompton
Women's Empowerment Through The Use Of Technology, Wolayat Tabasum Niroo, Helen Crompton
Teaching & Learning Faculty Publications
Technology has shaped people’s lifestyles globally. Today, the majority of the world’s population seeks help through technology as a portal to learning with the wide variety of learning materials available. Women in both developed and developing countries can access learning through technology, yet the scholarly community do not have an up-to-date collective view of how technology is being used to provide learning materials to empower women around the world. Therefore, this systematic review included an aggregated and qualitative synthesis to investigate extant empirical work over five years, 2017-2021. Following a rigorous PRISMA selection process, 40 articles were included in the …
Introducing Conditional Probability Using The Monty Hall Problem, Ricela Feliciano-Semidei
Introducing Conditional Probability Using The Monty Hall Problem, Ricela Feliciano-Semidei
Faculty Articles, Papers, and Other Scholarship
This study developed a teaching module that incorporated the Monty Hall problem to introduce conditional probability in a college introductory statistics course. This teaching module integrated a guess – experiment – discussion approach with game-based instruction. The researchers piloted this module and made modifications. The work of 20 non-mathematics major undergraduate students was examined for changes in their perceptions about conditional probability through a pre-and-post survey design. The Structure of the Observed Learning Outcome (SOLO) taxonomy was used for data analysis to show the quality of the student work. Findings suggest that most students’ perceptions were at higher levels after …
Biofouling Of Sensors In Narragansett Bay, Rhode Island, Kayla Kurtz
Biofouling Of Sensors In Narragansett Bay, Rhode Island, Kayla Kurtz
Open Access Dissertations
The objective of this study was to investigate the biofouling capacity and potential solutions for sensor devices in Narragansett Bay, Rhode Island. The dissertation was comprised of three main studies. First, the biofouling potential of several surface-enhanced Raman scat-tering (SERS)-based sensors was tested using zoospores from the common biofouling al-gae Ulva spp. Fluorescence microscopy was used to compare the adhesion of tubular Ulva spp. zoospores on commercial and novel SERS-based sensors including uncoated and gold (Au) silicon nanopillar array SERS substrates from Silmeco, Au coated carbon black nano-particle (AuCB NP) substrates, uncoated and Au sputter-coated in-house SERS created with a …
Optimal Shape Estimation And Methodologies For Towed Undersea Vehicles, Matthew J. Dellavalle, Peter Jasinski, Owen Driskill, Nick Sellers
Optimal Shape Estimation And Methodologies For Towed Undersea Vehicles, Matthew J. Dellavalle, Peter Jasinski, Owen Driskill, Nick Sellers
Mechanical Engineering Capstone Design Projects
Team 02 in part with Dr. Nassersharif, has been commissioned by the Naval Undersea Warfare Center to provide an optimal design and modeling for towed undersea vehicles. The proposed effort served to study, evaluate, and model the drag for the towing of cylindrical undersea vehicles. This project will model towing configurations for both single and multiple vehicle configurations. Recommendations were also made regarding the propulsion configuration of the leading vehicle. The proposed design solution aimed to achieve a drag coefficient of less than 0.3 to minimize the effect the towed vehicle may have on the range and endurance of its …
Antisocial Personality Disorder: A Theoretical Approach Utilizing Three Dimensions Of Power Analysis, Timothy J. Nguyen, Tara Zolnikov
Antisocial Personality Disorder: A Theoretical Approach Utilizing Three Dimensions Of Power Analysis, Timothy J. Nguyen, Tara Zolnikov
Faculty Research, Scholarly, and Creative Activity
Antisocial Personality Disorder (ASPD) is often associated with high costs and burden to the rest of society; however, it remains a disorder with no evidence of effective traditional psychological interventions. This theoretical study aimed to analyze the phenomenon of power and how it may influence the conceptualization of ASPD. Data was collected through a comprehensive and systematic review of the current ASPD literature. Findings suggested ASPD as severely conceptually flawed, highly imbalanced in terms of power dynamics between professionals and people diagnosed with ASPD, absent of participants’ voices, absent of any effective traditional psychotherapy interventions, disproportionately focused on deficit-oriented strategies …
Investigation Of Urinary Metabolomics In A Phase I Hookworm Vaccine Trial In Gabon, Madeleine Eunice Betouke Ongwe, Yoanne D Mouwenda, Koen A Stam, Peter G Kremsner, Bertrand Lell, David Diemert, Jeff Bethony, Maria E Bottazzi, Peter J Hotez, Remko V Leeuwen, Martin P Grobusch, Ayola A Adegnika, Oleg A Mayboroda, Maria Yazdanbakhsh
Investigation Of Urinary Metabolomics In A Phase I Hookworm Vaccine Trial In Gabon, Madeleine Eunice Betouke Ongwe, Yoanne D Mouwenda, Koen A Stam, Peter G Kremsner, Bertrand Lell, David Diemert, Jeff Bethony, Maria E Bottazzi, Peter J Hotez, Remko V Leeuwen, Martin P Grobusch, Ayola A Adegnika, Oleg A Mayboroda, Maria Yazdanbakhsh
Center for Medical Ethics and Health Policy Staff Publications
Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates (Na-GST-1 and Na-APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed using targeted 1H NMR spectroscopy. At baseline, a set of metabolites significantly distinguished rural from semi-urban individuals. The pre- and post-vaccination comparisons indicated significant …
Band Gap Information Extraction From Materials Science Literature – A Pilot Study, Satanu Ghosh, Kun Lu
Band Gap Information Extraction From Materials Science Literature – A Pilot Study, Satanu Ghosh, Kun Lu
Faculty Publications
Purpose
The purpose of this paper is to present a preliminary work on extracting band gap information of materials from academic papers. With increasing demand for renewable energy, band gap information will help material scientists design and implement novel photovoltaic (PV) cells.
Design/methodology/approach
The authors collected 1.44 million titles and abstracts of scholarly articles related to materials science, and then filtered the collection to 11,939 articles that potentially contain relevant information about materials and their band gap values. ChemDataExtractor was extended to extract information about PV materials and their band gap information. Evaluation was performed on randomly sampled information records …
Tooth Agenesis: Prevalence And Pattern Among Different Ethnicities, Gabrielle Coe
Tooth Agenesis: Prevalence And Pattern Among Different Ethnicities, Gabrielle Coe
All ETDs from UAB
Tooth agenesis is one of the most common developmental anomalies in humans and is defined as the failure of tooth development or odontogenesis. Prevalence of non-syndromic tooth agenesis has a reported range of 1.6-36.5% and varies by gender, ethnicity, and location. While tooth agenesis is well studied, information within ethnic groups requires further investigation. In this study, dental records of 3033 patients of the UAB School of Dentistry were evaluated to identify and categorize missing teeth by ethnicity and gender. Data analysis was conducted with Chi-square or Fisher’s exact test, with a two-sided significance level of 0.05. An overall prevalence …
Ecology Of The Diamondback Terrapin (Malaclemys Terrapin Pileata) In Alabama: Applications Of New Technologies, Forrest William Collins
Ecology Of The Diamondback Terrapin (Malaclemys Terrapin Pileata) In Alabama: Applications Of New Technologies, Forrest William Collins
All ETDs from UAB
The Diamondback Terrapin, Malaclemys terrapin pileata, inhabits saltmarshes in the Northern Gulf of Mexico including along the coast of Alabama. Due to a variety of factors, this species has declined drastically in Alabama, and it is currently designated as a “species of highest conservation concern”. Understanding the ecology of this species is a prerequisite to the recovery of this population. The current thesis addresses the reproductive and foraging ecology of the Diamondback Terrapin in Alabama. This thesis combines the use of classic ecological methodologies with modern technologies. Between April 2019 to July 2022, wild nesting females were caught at a …
The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron
The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron
All ETDs from UAB
A major obstacle to the advancement of our understanding of the metabolically healthy obesity (MHO) phenotype is the inconsistent definition of metabolic health and obesity among studies. A harmonized definition of MHO in adults has been proposed based on the diagnosis of obesity (BMI > 30 k/m2) and meeting the cardio-metabolic criteria for triglycerides, high-density lipoprotein (HDL) cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), no antihypertensive treatment, fasting blood glucose, and no drug treatment with glucose-lowering agents. In addition, waist circumference can be associated with increased disease risk when WC is >94 cm in men and >80 cm in …
Clinical Decision-Making: A Survey On The Influence Of Specialty And Experience In Treatment Planning Of Multidisciplinary Cases, Rawan Oueis
All ETDs from UAB
Objective: to evaluate the effect of specialization and experience on treatment planning multidisciplinary cases. Materials and Methods: A survey presenting 7 clinical scenarios and their potential treatment plans was designed and disseminated electronically to five groups of dentists (general dentists, endodontists, prosthodontists, orthodontists, periodontists). 509 responses were collected and analyzed for distribution and levels of agreement. Results: A moderate kappa was found (k=0.4-0.6) between endodontists and periodontists and within endodontists. There was no agreement on the type of restorations that are used between different specialties and within specialties of different years of experience. Conclusion: Specialists and general dentists use a …
Klf2 Regulation Of Glycocalyx Expression, Barrier Function, And Thromboinflammation In Human Lung Microvascular Endothelial Cells, Cambria O'Grady
Klf2 Regulation Of Glycocalyx Expression, Barrier Function, And Thromboinflammation In Human Lung Microvascular Endothelial Cells, Cambria O'Grady
All ETDs from UAB
KLF2 is an important transcription factor for maintaining vascular homeostasis. Its expression in endothelial cells is triggered by shear stress. The endothelial glycocalyx also plays a role in regulating vascular function, and prior work has shown that glycocalyx expression is affected by shear stress as well. However, the direct link between KLF2 and mechanisms that regulate glycocalyx synthesis has not been established. In the present study, we used human lung microvascular endothelial cells (HLMVECs) to observe changes in glycocalyx expression, barrier function, and thromboinflammation caused by KLF2 overexpression. Lentiviral transduction was the method used for KLF2 overexpression, resulting in a …
Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi
Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi
All ETDs from UAB
The differentiation of mesenchymal stem cells to pre-osteoblasts, lies upon various transcription factors and physiological signaling, but is also governed by the micro-RNA-23a cluster. The miR-23a cluster has miR-23a, miR-27a and miR-24-2 transcribed from a single promoter as a sole RNA primary transcript. Its effects have been observed in embryonic stem cells, mesenchymal stem cells (MSCs), and in cancer (1-2). It regulates the lineage commitment of MSCs. (3). With respect to bone formation, miR-23a cluster is involved MSCs commitment to and osteoblast maturation (4). Here, through in vivo and in vitro experiments, we report that knock down of microRNA-23a cluster …
Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang
Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang
All ETDs from UAB
Background: The food truck industry in the U.S. has rapidly expanded, with an average growth of 7.9 % from 2017 to 2022. Food truck workers are potentially exposed to harmful airborne contaminants such as particulate matter (PM) and aldehydes produced during cooking process. Kitchen exhaust hoods are designed to capture the cooking emissions, but it is not well understood whether the commercial kitchen exhaust hoods in food trucks are properly, efficiently operated to reduce the workers' exposure to such harmful contaminants. The purpose of the study was to evaluate food truck workers' exposure to respirable particulates generated from cooking process …
Alterations In Synaptic Structure And Tau Phosphorylation In Alheimer's Disease, Courtney K. Walker
Alterations In Synaptic Structure And Tau Phosphorylation In Alheimer's Disease, Courtney K. Walker
All ETDs from UAB
Alzheimer’s disease (AD) is the most common cause of dementia in individuals over the age of 65. Of the two hallmark pathologies of AD, tau neurofibrillary tangles (NFTs) correlate more strongly with cognitive decline than do Aβ plaques. NFTs form in the entorhinal cortex (EC) and appear in anatomically connected regions over time as disease progresses. This tau spreading may occur via synaptic connections. Most excitatory synapses occur on dendritic spines, which house the postsynaptic machinery. Spines are actin-rich, plastic structures that change their size and shape in response to synaptic activity in a process that is dependent on actin …
The Adoption Of New Cancer Drugs In Non-Academic Cancer Centers, Warren M. Smedley
The Adoption Of New Cancer Drugs In Non-Academic Cancer Centers, Warren M. Smedley
All ETDs from UAB
Advancements in medical knowledge are producing significant improvements in medical technology, developing breakthrough drug therapies, advancing the practice of medicine, and improving outcomes for cancer patients. However, there are delays in getting new and improved therapies incorporated into routine clinical use, depriving cancer patients of valuable and potentially lifesaving treatments. The purpose of this study was to examine the rate of adoption of new cancer drug discoveries into routine clinical practice in non-academic cancer centers. The process of adoption takes a period of time to embrace new therapies, due in part to a prescriber’s need to gain greater comfort with …
Renal Lactate Dehydrogenase A: Underlying Mechanisms And Inflammatory Roles In Acute Kidney Injury, Gunars Osis
Renal Lactate Dehydrogenase A: Underlying Mechanisms And Inflammatory Roles In Acute Kidney Injury, Gunars Osis
All ETDs from UAB
Kidneys are physiologically vital organs responsible for blood homeostasis preservation through fluid balance maintenance, blood pressure regulation, hormone production, and toxic compound removal. Acute kidney injury (AKI) is a global condition affecting more than 13 million people yearly, and is characterized by a rapid decline in renal filtration capacity, consequent rise in serum creatinine and nitrogenous waste levels, and is associated with an elevated risk of morbidity in the form of progressive chronic kidney disease, kidney failure, and mortality. AKI-induced renal epithelial cell death forces surviving tubular cells to undergo de-differentiation, rapid proliferation to replace lost cells, and re-differentiation to …
Relationship Between Neighborhood Deprivation And Epigenetic Age Acceleration With Pain In Adults With Musculoskeletal Pain, Pamela Jackson
Relationship Between Neighborhood Deprivation And Epigenetic Age Acceleration With Pain In Adults With Musculoskeletal Pain, Pamela Jackson
All ETDs from UAB
Residents of high-deprivation neighborhoods shoulder a greater burden of age-related health conditions, including experiencing worse chronic musculoskeletal pain outcomes, compared to residents of more affluent neighborhoods. Advancing age is a risk factor for chronic health conditions, which epigenetic modifications may explain. Epigenetic age acceleration occurs when an individual’s epigenetic age is older than their chronological age, and that discordance has been identified as a strong predictor of age-related conditions. Epigenetic age acceleration has also been correlated with neighborhood deprivation. However, the mechanisms for neighborhood disparities in chronic musculoskeletal pain remain unclear. The purpose of this dissertation study was to examine …
Hedgehog Signaling Rewires M2 Macrophage And Regulatory T Cell Metabolism Within The Tumor Microenvironment Of Breast Cancer, Dominique C. Hinshaw
Hedgehog Signaling Rewires M2 Macrophage And Regulatory T Cell Metabolism Within The Tumor Microenvironment Of Breast Cancer, Dominique C. Hinshaw
All ETDs from UAB
Current treatments for breast cancer offer little relief to patients with metastatic disease. A contributory factor to tumor growth and metastasis is aberrant up-regulation of developmental signaling pathways such as the Hedgehog (Hh) signaling pathway. This pathway is aberrantly activated in breast cancer and contributes to tumor progression and metastasis. The success of these events is highly influenced by the surrounding immune microenvironment. Macrophages exist along a spectrum of M1 (tumor-eradicating) to M2 (tumor-promoting), while regulatory T cells (Tregs) are an immunosuppressive cell type. The predominant functions of M2 macrophages and Tregs include dampening the immune response and promoting wound …
Comprehensive Characterization Of Structural Variations Using Long-Read Sequencing Data, Yu Chen
Comprehensive Characterization Of Structural Variations Using Long-Read Sequencing Data, Yu Chen
All ETDs from UAB
Structural variants (SVs) contribute to genomic diversity and play pathogenic roles in a wide range of genetic disorders. Accurate characterization of SVs is critical for genomic research and studies of disease mechanisms. The rapid development of Third-Generation Sequencing (TGS) technologies has largely increased sequencing read length compared to Next-Generation Sequencing (NGS), bringing both great potentials and challenges in SV discovery through alignment-based and assembly-based approaches. In order to take full advantage of TGS data, I have developed a suite of bioinformatics tools focusing on comprehensive characterization of SVs. For the alignment-based SV discovery, I have developed DeBreak to identify SVs …