Digital Commons Network^™

Formation Mechanism Of Coalbed Methane In Dafosi Mine Field, Huanglong Coalfield, Liu Kaide, Yao Kaiwen, Chen Nengyuan, Fan Zhangqun, Li Shujia, Zheng Han, Yue Wenping, Li Xiaolong

Coal Geology & Exploration

Dafosi mine field is a typical low-rank coalbed methane (CBM) field in Binchang mining area of Huanglong Jurassic. There are many coalbed methane wells in the field, but few researches are performed on the formation mechanism of coalbed methane. Thus, it is of great guiding significance to clarify the geochemical characteristics and formation mechanism of coalbed methane (CBM) in the mine field, which could provide important basis for the analysis on productivity difference of high- and low-yield CBM Wells. For this reason, the samples of drained gas at the wellhead of six CBM wells, 22 coal samples of No.4 coal …

A Non-Destructive Approach For Measuring Rice Panicle-Level Photosynthetic Responses Using 3d-Image Reconstruction, Jaspinder Singh Dharni, Balpreet Kaur Dhatt, Puneet Paul, Tian Gao, Tala Awada, Harel Bacher4, Zvi Peleg, Paul E. Staswick, Jason Hupp, Hongfeng Yu, Harkamal Walia

Department of Agronomy and Horticulture: Faculty Publications

Background: Our understanding of the physiological responses of rice inflorescence (panicle) to environmental stresses is limited by the challenge of accurately determining panicle photosynthetic parameters and their impact on grain yield. This is primarily due to the lack of a suitable gas exchange methodology for panicles and non-destructive methods to accurately determine panicle surface area.

Results: To address these challenges, we have developed a custom panicle gas exchange cylinder compatible with the LiCor 6800 Infra-red Gas Analyzer. Accurate surface area measurements were determined using 3D panicle imaging to normalize the panicle-level photosynthetic measurements. We observed differential responses in …

Contractual Complexity, Spencer Williams

Faculty Scholarship

Lawyers, judges, scholars, and clients all agree on one thing about contracts: they are complex. But what does this actually mean? What is contractual complexity and where does it come from? Despite widespread agreement that contracts are complex, the literature on contracts has yet to effectively define contractual complexity. Furthermore, the literature lacks a general theory of complexity that connects it to the broader body of contracts scholarship. This Article aims to fill these gaps. Drawing on complexity theory, the Article argues that contractual complexity is the degree of interactivity between a contract’s terms. Building on this definition, the Article …

Key Pretreatment Technologies For Coalbed Gas Bioengineering And Review On Their Mechanism Of Action, Bao Yuan, Chang Jianing, Liu Xiangrong, Xia Daping, Wang Yaya

Coal Geology & Exploration

Coalbed gas bioengineering (CGB) is a new technology for the purpose of realizing the clean utilization of coal resources and the enhanced recovery of coalbed gas. To explore the key characteristics of the pretreatment technologies of CGB, hydrocarbon generation potential and its mechanism of action, conclusion and summary was made for various pretreatment technologies herein. Meanwhile, the pretreatment technologies were divided into three types according to the action mode of coal (organic matter) and bacteria (microorganism): microflora optimization and improvement, coal dissolution and oxidation, and biological stimulation and synergy. By comparing the capability of coal to generate methane through microbial …

"The Missus Has Paid For Your Life.": Preconstituted Third-World Women In Chris Cleave's Little Bee, Jeanette P. Barry, Jeanette Parry Barry

Masters Theses

In “Under Western Eyes,” Chandra Mohanty explains how some Western feminist scholars unconsciously other third-world women by imposing on them their Eurocentric universality. Using Mohanty as a primary lens, this thesis argues that in Chris Cleave’s Little Bee (2008), the protagonists, Sarah and Little Bee, are respectively represented as a Western referent and a third-world preconstituted woman, rendering any true collaboration between them impossible. Little Bee is meant to enlighten its readers of the plight of refugees in the United Kingdom, and in some ways it does just that. Little Bee also, however, situates the English protagonist Sarah as a …

Neroimaging Of Brain Activaion Using Diffuse Optical Tomography, Jingyu Huang

USF Tampa Graduate Theses and Dissertations

This research has two parts. The first part focuses on the use of non-invasive imaging technique, diffuse optical tomography (DOT), to study the brain activation during the stimulation in the clinical room. It further extends the application of DOT by using it to monitor the hemodynamic response during the TMS stimulation in different parameters. Diffuse optical tomography (DOT) is based on NIR light that exploits the relative transparency of biological tissue. The part two and three extends the application in the hospital for delirium patient study and arm muscle dystrophy by adding the sources and detectors to monitor the brain …

Biochar Amended Biological Systems For Enhanced Landfill Leachate And Lignocellulosic Banana Waste Treatment, Xia Yang

USF Tampa Graduate Theses and Dissertations

Biochar is an inexpensive and environmentally friendly carbonaceous pyrolysis byproduct with a high surface area, pore volume, and adsorption capacities for inorganic and organic compounds. The goal of this dissertation is to evaluate the feasibility of biochar application in biological treatment systems for enhanced waste management. Three major objectives guided this research to provide a compressive understanding of biochar enhancement effects on biological treatment systems for contaminant removal, energy recovery, and environmental impacts as well as essential factors influencing biochar production and properties.

In Objective 1 a low-cost hybrid Constructed Wetland (CW) system modified with biochar/zeolite was developed for enhanced …

Leed Nd As A Tool For Evaluating The Quality Of Life In Egyptian Cities Case Study: Bilqas City, Dakahlia, Sarah A. Ibrahim, Esraa M. Elazab, Nanees A. Esayad, Mohammed Mekkawy

Mansoura Engineering Journal

Egyptian urban communities in the old cities suffer many urban issues. These issues affect the quality of the natural and built environment in which people live, work and have leisure. Promoting community quality and human satisfaction is the main focus of urban development. The notion of QOL as a result of urban communities’ development came into synchronization in the 60th. In 2007, the USGBC conducted the LEED-ND rating system to create more sustainable neighborhoods and raise the QOL for residents. This study focuses on the importance of QOL studies in the urban planning field and the coherence between the LEED-ND …

Inactivation Of Lats1/2 Drives Luminal-Basal Plasticity To Initiate Basal-Like Mammary Carcinomas, Joseph G Kern, Andrew M Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B Peppler, Eleni Stampouloglou, Nan Cheng, Randy L Johnson, Marc E Lenburg, Jennifer E Beane, Stefano Monti, Xaralabos Varelas

Faculty, Staff and Student Publications

Basal-like breast cancers, an aggressive breast cancer subtype that has poor treatment options, are thought to arise from luminal mammary epithelial cells that undergo basal plasticity through poorly understood mechanisms. Using genetic mouse models and ex vivo primary organoid cultures, we show that conditional co-deletion of the LATS1 and LATS2 kinases, key effectors of Hippo pathway signaling, in mature mammary luminal epithelial cells promotes the development of Krt14 and Sox9-expressing basal-like carcinomas that metastasize over time. Genetic co-deletion experiments revealed that phenotypes resulting from the loss of LATS1/2 activity are dependent on the transcriptional regulators YAP/TAZ. Gene expression analyses of …

K-12 Racial Equity Work In The Predominantly White Pacific Northwest: Interracial Conversations, Counter-Stories, And Considerations, Bradley Justin Parker

Dissertations and Theses

K-12 public education in the United States, post Brown v. Board of Education (1954), has historically maintained a predominantly White teaching force, and has persistently underserved students of Color in terms of academic, social, and emotional outcomes. Additionally, K-12 school-based racial equity work that strives to address the operation of racism is inconsistent, difficult to measure, and has not demonstrably created more racially equitable experiences or outcomes for students or educators of Color. In this project, I critically explore K-12 school-based efforts towards more racial equity in the predominantly White Pacific Northwest, and I take an intentional and critical look …

Standardized Multi-Omics Of Earth’S Microbiomes Reveals Microbial And Metabolite Diversity, Jp Shaffer, L-F Nothias, Lr Thompson, Earth Biome Project 500 Consortium

School of Biological and Marine Sciences

Despite advances in sequencing, lack of standardization makes comparisons across studies challenging and hampers insights into the structure and function of microbial communities across multiple habitats on a planetary scale. Here we present a multi-omics analysis of a diverse set of 880 microbial community samples collected for the Earth Microbiome Project. We include amplicon (16S, 18S, ITS) and shotgun metagenomic sequence data, and untargeted metabolomics data (liquid chromatography-tandem mass spectrometry and gas chromatography mass spectrometry). We used standardized protocols and analytical methods to characterize microbial communities, focusing on relationships and co-occurrences of microbially related metabolites and microbial taxa across environments, …

Metabolic Targeting Of Nrf2 Potentiates The Efficacy Of The Trap1 Inhibitor G-Tpp Through Reduction Of Ros Detoxification In Colorectal Cancer, Hong-Yuan Tsai, Mary P Bronner, Jordon K March, John F Valentine, Noah F Shroyer, Lisa A Lai, Teresa A Brentnall, Sheng Pan, Ru Chen

Faculty, Staff and Students Publications

Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial homolog of HSP90 chaperones. It plays an important role in protection against oxidative stress and apoptosis by regulating reactive oxidative species (ROS). To further elucidate the mechanistic role of TRAP1 in regulating tumor cell survival, we used gamitrinib-triphenylphosphonium (G-TPP) to inhibit TRAP1 signaling pathways in colon cancer. Inhibition of TRAP1 by G-TPP disrupted redox homeostasis and induced cell death. However, colon cancers show a wide range of responses to G-TPP treatment through the induction of variable ER stress responses and ROS accumulation. Interestingly, a strong inverse correlation was observed between …

"Life-Changing”- The Experience Of Super-Responders To Biologics In Severe Asthma, Joseph W. Lanario, Lucy Cartwright, Rupert C. Jones, Ross Sayers, Michael E. Hyland, Matthew Masoli

More Faculty of Health Research

Background There is limited information on the patient’s perspective of how biologic treatments impact their lives. We conducted a qualitative study to explore the patient’s experience of being considered a super-responder from a quality of life perspective. Methods Patients with severe asthma identified as super-responders were invited to semi-structured interviews conducted online. Participants could bring a family member/friend to the interview. The interviews explored experiences of biologic treatment, were transcribed and underwent thematic analysis. Results Twenty-five participants took part in this study. Themes emerged on the impact of biologic treatment for participants and for their friends/family: (i) Words used to …

Tritiated Steel Micro-Particles: Computational Dosimetry And Prediction Of Radiation-Induced Dna Damage For In Vitro Cell Culture Exposures, Alice Mentana, Yordenca Lamartinière, Thierry Orsière, Véronique Malard, Mickaël Payet, Danielle Slomberg, Isabella Guardamagna, Leonardo Lonati, Cristian Grisolia, Awadhesh Jha, Laurence Lebaron-Jacobs, Jerome Rose, Andrea Ottolenghi, Giorgio Baiocco

School of Biological and Marine Sciences

Biological effects of radioactive particles can be experimentally investigated in vitro as a function of particle concentration, specific activity and exposure time. However, a careful dosimetric analysis is needed to elucidate the role of radiation emitted by radioactive products in inducing cyto- and geno-toxicity: the quantification of radiation dose is essential to eventually inform dose-risk correlations. This is even more fundamental when radioactive particles are short-range emitters and when they have a chemical speciation that might further concur to the heterogeneity of energy deposition at the cellular and sub-cellular level. To this aim, we need to use computational models. In …

Comprehensive Transcriptomic Analysis Of Vista In Acute Myeloid Leukemia: Insights Into Its Prognostic Value, Simona Pagliuca, Carmelo Gurnari, Keman Zhang, Tariq Kewan, Waled Bahaj, Minako Mori, Ishani Nautiyal, Marie Thérèse Rubio, Francesca Ferraro, Jaroslaw P Maciejewski, Li Wang, Valeria Visconte

2020-Current year OA Pubs

The V-domain Ig suppressor of T-cell activation (VISTA) has been recognized as a critical negative regulator of antitumor immune response and is gaining growing interest as a potential pharmacological target in immunotherapy. This molecule is highly expressed in hematopoietic stem cells and myeloid compartment, and it has been found upmodulated in acute myeloid leukemia (AML). However, VISTA-associated immune features are relatively unexplored in myeloid malignancies. Herein, we aimed to explore whether this immune checkpoint regulator could play a role in the generation of an immune escape environment in AML patients. We characterized VISTA mRNA expression levels in leukemia cell lines …

A Multiple Input Multiple Output Framework For The Automatic Optical Fractionator-Based Cell Counting In Z-Stacks Using Deep Learning, Palak Dave

USF Tampa Graduate Theses and Dissertations

Quantifying cells in a defined region of biological tissue is critical for many clinical and preclinical studies, especially in pathology, toxicology, cancer, and behavior. Unbiased stereology is the state-of-art method for quantification of the total number and other morphometric parameters of stained objects in a defined region of biological tissue. As part of a program to develop accurate, precise, and more efficient automatic approaches for quantifying morphometric changes in biological tissue, our group has shown that both deep learning-based and hand-crafted algorithms can estimate the total number of histologically stained cells at their maximal profile of focus in extended depth …

Structural And Functional Magnetic Resonance Imaging Correlates Of Fatigue And Dual-Task Performance In Progressive Multiple Sclerosis, Paolo Preziosa, Maria A. Rocca, Elisabetta Pagani, Paola Valsasina, Maria Pia Amato, Giampaolo Brichetto, Nicolò Bruschi, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Alessandro Meani, Cecilia Meza, Robert W. Motl, Amber Salter, Brian M. Sandroff, Anthony Feinstein, Massimo Filippi

School of Health Professions

BACKGROUND: Frontal cortico-subcortical dysfunction may contribute to fatigue and dual-task impairment of walking and cognition in progressive multiple sclerosis (PMS). PURPOSE: To explore the associations among fatigue, dual-task performance and structural and functional abnormalities of frontal cortico-subcortical network in PMS. METHODS: Brain 3 T structural and functional MRI sequences, Modified Fatigue Impact Scale (MFIS), dual-task motor and cognitive performances were obtained from 57 PMS patients and 10 healthy controls (HC). The associations of thalamic, caudate nucleus and dorsolateral prefrontal cortex (DLPFC) atrophy, microstructural abnormalities of their connections and their resting state effective connectivity (RS-EC) with fatigue and dual-task performance were …

Amplification Of The Plag-Family Genes-Plagl1 And Plagl2-Is A Key Feature Of The Novel Tumor Type Cns Embryonal Tumor With Plagl Amplification, Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Nasir Uddin

Department of Pathology and Laboratory Medicine

Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0-14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well as a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification in combination with copy number, RNA-seq, and ChIP-seq analysis to characterize a newly identified CNS tumor type. In addition, we report histology, patient characteristics, and survival data in this tumor type. We describe a biologically distinct pediatric CNS tumor type (n = 31 cases) that is characterized by focal …

Lo, Q, Rheros Iliad Kagoni

Querying the Past: LGBTQ Maine Oral History Project Collection

Q Lo is a 45 year old transgender man, the son of two Chinese immigrants who grew up in New York. Q discusses growing up as a queer person of color, how his gender and sexual identity was impacted by the lack of representation he saw around him, how his upbringing in Chinatown influenced his view of the world, and how his immigrant parents influenced his relationship with school, work and creativity. Q talks about attending college, dropping out of college, and his experiences going to MECA in Portland Maine while grappling with the classism and privilege he was experiencing …

Influence Of Salts On The Photocatalytic Degradation Of Formic Acid In Wastewater, Azzah Nazihah Che Abdul Rahim, Shotaro Yamada, Haruki Bonkohara, Tsuyoshi Imai, Yung-Tse Hung, Izumi Kumakiri

Civil and Environmental Engineering Faculty Publications

Conventional wastewater treatment technologies have difficulties in feasibly removing persistent organics. The photocatalytic oxidation of these contaminants offers an economical and environmentally friendly solution. In this study, TiO2 membranes and Ag/TiO2 membranes were prepared and used for the decomposition of dissolved formic acid in wastewater. The photochemical deposition of silver on a TiO2 membrane improved the decomposition rate. The rate doubled by depositing ca. 2.5 mg of Ag per 1 g of TiO2. The influence of salinity on formic acid decomposition was studied. The presence of inorganic salts reduced the treatment performance of the TiO2 membranes to half. Ag/TiO2 membranes …

Comprehensive Review Of Cardiovascular Disease Risk In Nonalcoholic Fatty Liver Disease, Kevan Josloff, Jacob Beiriger, Adnan Khan, Richard J. Gawel, Richard S. Kirby, Aaron Kendrick, Abhinav K. Rao, Roy Wang, Michelle Schafer, Margaret Pearce, Kashyap Chauhan, Yash B. Shah, Gregary D. Marhefka, Dina Halegoua-De Marzio

Department of Medicine Faculty Papers

Nonalcoholic Fatty Liver Disease (NAFLD) is a growing global phenomenon, and its damaging effects in terms of cardiovascular disease (CVD) risk are becoming more apparent. NAFLD is estimated to affect around one quarter of the world population and is often comorbid with other metabolic disorders including diabetes mellitus, hypertension, coronary artery disease, and metabolic syndrome. In this review, we examine the current evidence describing the many ways that NAFLD itself increases CVD risk. We also discuss the emerging and complex biochemical relationship between NAFLD and its common comorbid conditions, and how they coalesce to increase CVD risk. With NAFLD's rising …

From Old School To New School, Andy Belt

University of Mississippi News

Rivers gift goes toward state-of-the-art accountancy building

Clinical And Molecular Insights Into Gastrointestinal Dysfunction In Myotonic Dystrophy Types 1 & 2, Janel A M Peterson, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy (DM) is a highly variable, multisystemic disorder that clinically affects one in 8000 individuals. While research has predominantly focused on the symptoms and pathological mechanisms affecting striated muscle and brain, DM patient surveys have identified a high prevalence for gastrointestinal (GI) symptoms amongst affected individuals. Clinical studies have identified chronic and progressive dysfunction of the esophagus, stomach, liver and gallbladder, small and large intestine, and rectum and anal sphincters. Despite the high incidence of GI dysmotility in DM, little is known regarding the pathological mechanisms leading to GI dysfunction. In this review, we summarize results from clinical and …

Memes From Confinement: Disorientation And Hindsight Projection In The Crisis Of Covid-19, David Divita

Pomona Faculty Publications and Research

Memes have been described as textual forms of “(post)modern folklore” (Shifman, 2014: 5). Photos or short videos, they highlight current cultural phenomena, and they spread exponentially through person-to-person sharing on social media platforms. For this article, I created a corpus of memes that circulated in March 2020, during the first weeks after statewide lockdown orders were issued in the U.S. in response to the COVID-19 pandemic. Drawing on Bakthin’s (1981) concept of the chronotope, I analyze a subset of these memes that specifically addressed the experience of time in confinement, illuminating two interrelated trends: the disruption of temporal order in …

Spirochete, Felicia Bedford

D.U.Quark

No abstract provided.

Variation In Human Water Turnover Associated With Environmental And Lifestyle Factors, Yosuke Yamada, Xueying Zhang, Mary E.T. Henderson, Hiroyuki Sagayama, Herman Pontzer, Daiki Watanabe, Tsukasa Yoshida, Misaka Kimura, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. Camps, Graeme L. Close, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Lara R. Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris

Faculty Publications

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development …

Dynamic Regulation Of Phenylpropanoid Pathway Metabolites In Modulating Sorghum Defense Against Fall Armyworm, Sajjan Grover, Sanket Shinde, Heena Puri, Nathan Palmer, Gautam Sarath, Scott E. Sattler, Joe Louis

Department of Entomology: Faculty Publications

Plants undergo dynamic metabolic changes at the cellular level upon insect infestation to better defend themselves. Phenylpropanoids, a hub of secondary plant metabolites, encompass a wide range of compounds that can contribute to insect resistance. Here, the role of sorghum (Sorghum bicolor) phenylpropanoids in providing defense against the chewing herbivore, fall armyworm (FAW), Spodoptera frugiperda, was explored. We screened a panel of nested association mapping (NAM) founder lines against FAW and identified SC1345 and Ajabsido as most resistant and susceptible lines to FAW, respectively, compared to reference parent, RTx430. Gene expression and metabolomic studies suggested that FAW …

A Real-Time Ultrasound Simulation Platform Using Ray Tracing And Its Integration With Virtual Reality, Bo Peng, Qiang Wang, Ruibing Qing, Lixue Yin, Jingfeng Jiang

Journal of System Simulation

Abstract: In order to further improve the efficacy of ultrasound training and reduce the cost. An ultrasound training system that is integrated with a VR environment is developed. The main contribution of this study is to incorporate the Ray-tracing based ultrasound image simulation approach into a virtual reality environment, taking advantage of immersive VR experience for medical ultrasound training. The simulated ultrasound images obtained by the proposed method are then compared to images that are simulated using a generative adversarial network (GAN) technique and Field II ultrasound simulator. The data show that the ultrasound simulator can produce high-quality simulated …

Variation In Human Water Turnover Associated With Environmental And Lifestyle Factors, Yosuke Yamada, Xueying Zhang, Mary E T Henderson, Hiroyuki Sagayama, Herman Pontzer, Daiki Watanabe, Tsukasa Yoshida, Misaka Kimura, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Lewis G Halsey, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, William E Kraus, Wantanee Kriengsinyos, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Leanne M Redman, John J Reilly, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Luis B Sardinha, Analiza M Silva, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack A Yanovski, Alexia J Murphy-Alford, Cornelia U Loechl, Amy H Luke, Jennifer Rood, Klaas R Westerterp, William W Wong, Motohiko Miyachi, Dale A Schoeller, John R Speakman

Children’s Nutrition Research Center Staff Publications

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lack access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5,604 people from the ages of 8 days to 96 years from 26 countries using isotope tracking (2H) methods. Age, body size, and composition were significantly associated with WT as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People in countries with low human development index (HDI) …

Oxphos Promotes Apoptotic Resistance And Cellular Persistence In Th17 Cells In The Periphery And Tumor Microenvironment, Hanna S Hong, Nneka E Mbah, Mengrou Shan, Kristen Loesel, Lin Lin, Peter Sajjakulnukit, Luis O Correa, Anthony Andren, Jason Lin, Atsushi Hayashi, Brian Magnuson, Judy Chen, Zhaoheng Li, Yuying Xie, Li Zhang, Daniel R Goldstein, Shannon A Carty, Yu Leo Lei, Anthony W Opipari, Rafael J Argüello, Ilona Kryczek, Nobuhiko Kamada, Weiping Zou, Luigi Franchi, Costas A Lyssiotis

Faculty, Staff and Student Publications

T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (TH17s) are mediators of host defense, autoimmunity, and antitumor immunity in the setting of adoptive T cell therapy. TH17s are long-lived cells that require mitochondrial oxidative phosphorylation (OXPHOS) for effector function in vivo. Considering that TH17s polarized under standardized culture conditions are predominately glycolytic, little is known about how OXPHOS regulates TH17 processes, such as their ability to persist and thus contribute to …