Digital Commons Network^™

Differential Roles Of Aβ42/40, P-Tau231 And P-Tau217 For Alzheimer's Trial Selection And Disease Monitoring, Nicholas J Ashton, Yan Li, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Blood biomarkers indicative of Alzheimer's disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for the identification of AD pathology or monitoring of disease progression. Blood biomarkers that correlate with changes in cognition and atrophy during the course of the disease could be used in clinical trials to identify successful interventions and thereby accelerate the development of efficient therapies. When disease-modifying treatments become approved for use, efficient blood-based biomarkers might also inform on treatment implementation and management in clinical practice. In the BioFINDER-1 cohort, plasma phosphorylated (p)-tau231 and amyloid-β42/40 ratio …

Transferability Of Alzheimer Disease Polygenic Risk Score Across Populations And Its Association With Alzheimer Disease-Related Phenotypes, Sang-Hyuk Jung, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Polygenic risk scores (PRSs), which aggregate the genetic effects of single-nucleotide variants identified in genome-wide association studies (GWASs), can help distinguish individuals at a high genetic risk for Alzheimer disease (AD). However, genetic studies have predominantly focused on populations of European ancestry.

OBJECTIVE: To evaluate the transferability of a PRS for AD in the Korean population using summary statistics from a prior GWAS of European populations.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study developed a PRS based on the summary statistics of a large-scale GWAS of a European population (the International Genomics of Alzheimer Project; 21 982 AD cases …

Segment-Wise Time-Varying Dynamic Bayesian Network With Graph Regularization, Xing Yang, Chen Zhang, Baihua Zheng

Research Collection School Of Computing and Information Systems

Time-varying dynamic Bayesian network (TVDBN) is essential for describing time-evolving directed conditional dependence structures in complex multivariate systems. In this article, we construct a TVDBN model, together with a score-based method for its structure learning. The model adopts a vector autoregressive (VAR) model to describe inter-slice and intra-slice relations between variables. By allowing VAR parameters to change segment-wisely over time, the time-varying dynamics of the network structure can be described. Furthermore, considering some external information can provide additional similarity information of variables. Graph Laplacian is further imposed to regularize similar nodes to have similar network structures. The regularized maximum a …

Listeria Motility Increases The Efficiency Of Epithelial Invasion During Intestinal Infection, Inge M. N. Wortel, Seonyoung Kim, Annie Y. Liu, Enid C. Ibarra, Mark J. Miller

2020-Current year OA Pubs

Listeria monocytogenes (Lm) is a food-borne pathogen that causes severe bacterial gastroenteritis, with high rates of hospitalization and mortality. Lm is ubiquitous in soil, water and livestock, and can survive and proliferate at low temperatures. Following oral ingestion of contaminated food, Lm crosses the epithelium through intestinal goblet cells in a mechanism mediated by Lm InlA binding host E-cadherin. Importantly, human infections typically occur with Lm growing at or below room temperature, which is flagellated and motile. Even though many important human bacterial pathogens are flagellated, little is known regarding the effect of Lm motility on invasion and immune evasion. …

Mouse Tissue Harvest-Induced Hypoxia Rapidly Alters The In Vivo Metabolome, Between-Genotype Metabolite Level Differences, And 13c-Tracing Enrichments, Adam J Rauckhorst, Nicholas Borcherding, Daniel J Pape, Alora S Kraus, Diego A Scerbo, Eric B Taylor

2020-Current year OA Pubs

OBJECTIVE: Metabolomics as an approach to solve biological problems is exponentially increasing in use. Thus, this a pivotal time for the adoption of best practices. It is well known that disrupted tissue oxygen supply rapidly alters cellular energy charge. However, the speed and extent to which delayed mouse tissue freezing after dissection alters the broad metabolome is not well described. Furthermore, how tissue genotype may modulate such metabolomic drift and the degree to which traced

METHODS: By combined liquid chromatography (LC)- and gas chromatography (GC)-mass spectrometry (MS), we measured how levels of 255 mouse liver metabolites changed following 30-second, 1-minute, …

G Protein Gamma Subunit, A Hidden Master Regulator Of Gpcr Signaling, Dinesh Kankanamge, Mithila Tennakoon, Ajith Karunarathne, N Gautam

2020-Current year OA Pubs

Heterotrimeric G proteins (αβγ subunits) that are activated by G protein-coupled receptors (GPCRs) mediate the biological responses of eukaryotic cells to extracellular signals. The α subunits and the tightly bound βγ subunit complex of G proteins have been extensively studied and shown to control the activity of effector molecules. In contrast, the potential roles of the large family of γ subunits have been less studied. In this review, we focus on present knowledge about these proteins. Induced loss of individual γ subunit types in animal and plant models result in strikingly distinct phenotypes indicating that γ subtypes play important and …

The Role Of Akirin/Nurd Interactions During Heart Development, Mia Jones

Symposium of Student Scholars

Congenital heart defects are often identified during pregnancy or infancy and are the most common birth defect presented in humans, affecting blood circulation resultant from small holes in a blood chamber to deformity-inducing missing structures. Recent advancements in medicine have allowed those affected to live healthier, longer lives. Gene combinations and chromosomal changes play pivotal roles in congenital heart defects, but the specific genes involved remain unknown. The Nowak Lab has discovered several novel regulatory proteins that are critical for embryonic heart development and is studying them for a potential link to congenital heart defects.

During embryogenesis, the heart of …

Evaluation Of Differences In Testosterone Concentration Among Species, Sexes, And Reproductive Tactics In Two-Lined Salamanders, Zaynab Massenburg

Symposium of Student Scholars

Fall 2022 symposium abstract:

Evaluation of differences in testosterone concentration among species, sexes, and reproductive tactics in two-lined salamanders

Zaynab Massenburg(1), Michelle Ross(1)

[[email protected], [email protected]]

(1) Kennesaw State University

Inhabiting streams in the Appalachian Mountains in northern Georgia are two sympatric and closely related species of plethodontid salamanders—Brown-backed Salamanders (Eurycea aquatica) and Blue Ridge Two-lined Salamanders (Eurycea cf. wilderae). Male Eurycea cf. wilderae exhibit a morphological polymorphism corresponding to alternative reproductive tactics. “Searching” males display brighter coloration, the presence of cirri and a mental glad, and mate-searching behavior, while “guarding” males display hypertrophied jaw musculature, lack cirri and a mental …

Review Of Christianity And Depression, Robert D. Mcbain

Spiritus: ORU Journal of Theology

Christianity and Depression. By Tasia Scrutton. London, UK: SCM Press, 2020. xvi + 236 pp.

Exploring Stress Mindset And Perceived Stress Between College Student-Athletes And Non-Athletes, Creighton Avery, Amber M. Shipherd, Sarah Gomez, Kelly B. Renner

International Journal of Exercise Science

International Journal of Exercise Science 15(5): 1554-1562, 2022. One’s beliefs about the nature of stress (e.g., stress mindset) play a large role in the extent to which one experiences the detrimental or beneficial outcomes of stress. Stress mindset has been explored in college students, but there is limited research on stress mindsets in student-athletes. Sport can serve as a buffer to the negative impacts of stress for some student-athletes; however, pressures associated with sport participation increase stress in other student-athletes. Therefore, the purpose was to examine potential differences in stress mindset and perceived stress between non-athletes and college student-athletes. We …

Tree Provision Achieving Kid’S Thermal Comfort Through Finishing Material Performance In Subtropical Outdoor Playgrounds. Comparison Between King Fahed And Al Biaa Garden In Tripoli, Lebanon, Houda Kabbara, Eslam M. Elsamahy, Mary Felix

BAU Journal - Creative Sustainable Development

Outdoor playgrounds are one of the most spaces needed for kids to make different types of activities, and enhancing thermal comfort in such space consist a critical value due to its impact on kids’ health. Unfortunately, the acceleration of urban heat island (UHI) in outdoor spaces, caused by the presence built-up area has affected the temperature of outdoor spaces especially playgrounds. Many researches highlighted the importance of studying outdoor playground materials to achieve kid’s thermal comfort. Nevertheless, analyzing the impact of providing trees on material performance consist a new research perspective. This research highlight on the importance of using trees …

Panarchy Suggests Why Management Mitigates Rather Than Restores Ecosystems From Anthropogenic Impact, David G. Angeler, Ran Hur

School of Natural Resources: Faculty Publications

Panarchy, a model of dynamic systems change at multiple, interconnected spatiotemporal scales, allows assessing whether management influences ecological processes and resilience. We assessed whether liming, a management action to counteract anthropogenic acidification, influenced scale-specific temporal fluctuation frequencies of benthic invertebrates and phytoplankton assemblages in lakes. We also tested whether these fluctuations correlated with proxies of liming (Ca:Mg ratios) to quantify scale-specific management effects. Using an ecosystem experiment and monitoring data, time series analyses (1998–2019) revealed significant multiscale temporal (and thus panarchy) structure for littoral invertebrates across limed and reference lakes. Such patterns were inconsistent for sublittoral invertebrates and phytoplankton. When …

Exploring Perceptions Of Control Within Offender Cognition And Recidivism Paradigms, Anistasha H. Lightning, Danielle Polage

Student Published Works

Elements of perceived control are associated with recidivism in offender populations. We investigated the application of locus of control to the frequency of personal involvement with the law and to beliefs surrounding the likelihood of future contact with the legal system. We hypothesized that, as the number of sentencings or legal experiences increased, locus of control would externalize. We also predicted that increased legal involvement would lead to greater belief in the likelihood of future involvement. A statistically significant path model suggests that locus of control appears to be a predictor of increased criminality, as opposed to the other way …

Commonwealth Times 2022-11-30

Commonwealth Times, 1969-

No abstract provided.

Arch Rock (Width In Millimeters), Peter G. Butterfield, Ryan W. Mcewan

Data Files: White Oaks in Vinton Furnace Experimental Forest

Data in this collection regards white oak trees (Quercus alba) in Vinton Furnace Experimental Forest, Vinton County, Ohio. Affiliated images are available at http://ecommons.udayton.edu/mcewanlab_6_images.

File type: .csv

About the data:

• Column A: Year
• Column B and onward: Measurements of tree rings in millimeters; sample title appears in row 1
• Measurements taken using a Velmex Unislide and the Tellervo software application.

A Common Mechanism Links Epstein‐Barr Virus Infections And Autoimmune Diseases, Luwen Zhang

Nebraska Center for Virology: Faculty Publications

Epstein‐Barr virus (EBV) infection is associated with a variety of the autoimmune diseases. There is apparently no unified model for the role of EBV in autoimmune diseases. In this article, the development of autoimmune diseases is proposed as a simple two‐step process: specific autoimmune initiators may cause irreversible changes to genetic materials that increase autoimmune risks, and autoimmune promoters promote autoimmune disease formation once cells are susceptible to autoimmunity. EBV has several types of latencies including type III latency with higher proliferation potential. EBV could serve as autoimmune initiators for some autoimmune diseases. At the same time, EBV may play …

Wics Conference 2022: Driving Research, Teaching, And Extension Impact, Daren Redfearn, Daran Rudnick

Water and Integrated Cropping Systems Conferences

The Water and Integrated Cropping Systems (WICS) Hub was established to facilitate and provide collaborative opportunities for IANR faculty to leverage their individual and collective knowledge, talents, and interests to drive impact in Research and Discovery, Teaching and Learning, Extension and Outreach. This past year we focused on building connections as well as identifying and prioritizing big challenges and opportunities facing Nebraskans. The faculty identified and organized around the following themes, Digital/Precision Agriculture, Soil Health, Integrated Cropping Systems, Water Quality, and Water Quantity. The Theme Groups are faculty led and multi-disciplinary with representation across IANR Departments and Faculty appointments. We …

White Matter Hyperintensity Load Is Associated With Premature Brain Aging, Natalie Busby, Sarah Newman-Norlund, Sara Sayers, Roger Newman-Norlund, Sarah Wilson, Samaneh Nemati, Chris Rorden, Janina Wilmskoetter, Nicholas Riccardi, Rebecca Roth, Julius Fridriksson, Leonardo Bonilha

Faculty Publications

Background: Brain age is an MRI-derived estimate of brain tissue loss that has a similar pattern to aging-related atrophy. White matter hyperintensities (WMHs) are neuroimaging markers of small vessel disease and may represent subtle signs of brain compromise. We tested the hypothesis that WMHs are independently associated with premature brain age in an original aging cohort.

Methods: Brain age was calculated using machine-learning on whole-brain tissue estimates from T1-weighted images using the BrainAgeR analysis pipeline in 166 healthy adult participants. WMHs were manually delineated on FLAIR images. WMH load was defined as the cumulative volume of WMHs. A positive difference …

Interconnected Precarity: A Contemporary Reframing Of Bodily And Earthly Health In Wendell Berry's The Unsettling Of America: Culture And Agriculture, Abigail Pinegar

Theses and Dissertations

Published in 1977, Wendell Berry's book The Unsettling of America: Culture and Agriculture gained widespread popularity. More than half a century later, many of the notions of the body and the earth presented in its seventh chapter, "The Body and the Earth," remain relevant and important for environmental discourse today. Berry's discussion of the body and the earth examines their mutuality and codependence from an ontological, theological, agricultural, and even biological perspective. The coupling of this text with Judith Butler's, Frames of War: When is Life Grievable? contemporizes his argument through its more socio-political and philosophical claims regarding life and …

Evaluation Of The Effects Of Pine-Sourced Biochar On Cattle Performance And Methane And Carbon Dioxide Production From Growing And Finishing Steers, J. L. Sperber, B. C. Troyer, Galen E. Erickson, Andrea K. Watson

Department of Animal Science: Faculty Publications

A feedlot growing (77-d) and finishing (111-d) experiment was conducted to evaluate the effects of feeding biochar on steer performance, methane and carbon dioxide emissions, and carcass characteristics. Two treatments were evaluated, a control diet without biochar and the same diet with biochar included at 0.8% of dietary DM (growing) or 1.0% of dietary DM (finishing). The growing diet consisted of 40% corn silage, 40% wheat straw, 15% modified distillers grains plus solubles, and 5% supplement, with 0.8% biochar replacing fine ground corn in supplement. The finishing diet consisted of 55% high-moisture corn (HMC), 35% Sweet Bran, 5% wheat straw, …

Implementation Of Blended Learning In The Pademic Era Of Covid-19: The Effect Of Motivation On Learningoutcomes In Vocational School Students' Mechanical Engineering Drawing Subject, Tuwoso Tuwoso, Purnomo Purnomo, Abd Kadir Bin Mahamad

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The emergence of the COVID-19 virus has had a major impact on various sectors, one of which is the education sector. This greatly hampers the learning process for students, especially in SMK. As a middle ground, several vocational schools have implemented blended learning, which combines face-to-face learning with online learning. The application of blended learning in schools received a good response from teachers and students. The purpose of this study was to determine the effect of motivation with student learning outcomes in the subject of Mechanical Engineering Drawing on the application of blended learning. Research method, this research is ex …

Analyzing Interactions Of Calmodulin With Hiv-1 Matrix Protein, Andrea Sandoval, D. Mau, N. Karimi, K. Sakamaki, C. Owens, Jerry Larue

Student Scholar Symposium Abstracts and Posters

Human immunodeficiency virus (HIV) attacks the immune system and if left untreated, could cause acquired immunodeficiency syndrome (AIDS). The HIV matrix protein (HIV-MA) is involved in replication and regulation of the HIV virus. Calmodulin (CaM), a calcium-binding protein found in all eukaryotes, has a potential role in the viral replication of HIV-MA which plays a key role in the replication of HIV. In order to investigate the interactions between calmodulin and the HIV-MA, a series of titrations with CaM are performed using circular dichroism. Circular dichroism (CD) uses circularly polarized light to observe the secondary structure of a molecule. The …

Biopolitics And Belief: The Impacts Of Religious Attitudes On Reproductive Rights In The U.S., Katlyn Barbaccia

Student Scholar Symposium Abstracts and Posters

On June 24, 2022, the U.S. Supreme Court ruled to overturn Roe v. Wade (1973)—a groundbreaking case that legalized the right to have an abortion—which signified a deep rift in the nation between the opinions of its lawmakers and citizens in the wake of a widening partisan gap. Biopower, according to Foucault, can be defined as the governing of bodies wherein citizens are stripped of bodily autonomy and are closely regulated by the nation-state. Manifested in political consequences, this can be defined as biopolitics, or when the nation-state’s ideas are made into a reality in the political realm. …

2022-11-30 Thanksgiving Calorie Counting And The Perpetuation Of Diet Culture, Chloe Platt

The Spectator Online

No abstract provided.

2022-11-30 Time Out Session: Cameron Tyson Looks To Continue Success, Tyra Okuda

The Spectator Online

No abstract provided.

November 30, 2022 (Vol. 107, No. 13), Daily Eastern News

Daily Eastern News: 2022-2023

No abstract provided.

Assessment Of Carrying Capacity Sangalaki Island Natural Tourism Park, Berau Regency, Joko Mijiarto, Eva Rachmawati

Jurnal Penelitian Kehutanan Wallacea

Sangalaki Island Nature Tourism Park (NTP) is one of the tourist destinations in Derawan. As a conservation area, tourism development in Sangalaki Island NTP must pay attention to the carrying capacity of the area. The purpose of this research is to calculate the carrying capacity in the NTP area of Sangalaki Island. The research was conducted in October 2021 through literature studies, field observations, and interviews. The calculation of the carrying capacity is carried out with the concept of Physical Carrying Capacity (PCC). The PCC of the area in Sangalaki Island NTP is 259 people/day with details of beach tourism …

Vegetation Diversity Of Hemaq Beniung Customary Forest, West Kutai, East Kalimantan, Swandari Paramita, Raharjo Ari Suwasono, Lasmito, Iya’ Setyasih, Ariyanto, Rachmad Mulyadi, Yohanes Budi Sulistioadi

Jurnal Penelitian Kehutanan Wallacea

Indonesia is a biodiversity-rich country with the second-largest tropical forest in the world. One East KalimantanForest area in focus is the Hemaq Beniung Customary Forest. The Hemaq Beniung Customary Forest is the first customary forest with its license granted in East Kalimantan by the Ministry of Environment and Forestryof the Republic of Indonesia. Information on vegetation diversity is essential to ensure sustainable management of this forest area. This research provides such information through a survey with purposively chosen samples representing HemaqBeniung Customary Forest. The study reveals that the Importance Value Index of vegetation in different habitus (i.e., seedling, sapling, pole, …

Composition, Domination, And Similarity Level Of Stand Among Farmers' Cultivated Blocks At Wan Abdul Rachman Grand Forest Park, Indriyanto

Jurnal Penelitian Kehutanan Wallacea

The tree species preferred by forest farmers are not always the same, so that in each farmers cultivated block it is possible to form forest stands with a certain composition. The research aimed to analyze the composition of tree species, dominant tree species, and similarity level of species composition among the farmer’s cultivated block. The research was conducted from August until December 2020. Data collection was carried out with a vegetation survey using nested rectangular plots with a sampling intensity of 1%. The data collected includes tree species, tree height, basal area, and individual number of each species. Data were …

Distribution Of Mangrove Health In The Coastal Area Of Maros Regency In 2021 Based On Sentinel 2 Satellite Imagery, Muh Faisal Mappiasse, Muliana Djafar, Reza Asra

Jurnal Penelitian Kehutanan Wallacea

Changes in the area of mangroves in the coastal area of Maros Regency have been degraded from year to year. Various problems that often occur cause a decrease in the distribution and quality of mangrove community health. This happens because there is still pollution and external disturbances which make the quality of the mangroves decrease. Therefore, it is important to know the condition of mangrove distribution to find the latest information and baseline data for area managers. The purpose of this study was to obtain information on the extent and type of mangrove health, as well as identify the types …