Digital Commons Network^™

Dermatologic Manifestations Of Rheumatic Disease: Cutaneous Manifestations Of Sarcoidosis, Sarah Shapiro, Sindhuja Koppu, Mavra Masood, Beth Rubinstein, Huzaefah Syed

Open and Affordable Course Content at VCU

No abstract provided.

Andrews University Press 2022 Booklist, Andrews University Press

Booklists

No abstract provided.

Behavioral Therapies For Treating Female Sexual Dysfunctions: A State-Of-The-Art Review, Gemma Mestre-Bach, Gretchen R. Blycker, Marc D. Potenza

College of Nursing Faculty Publications

No abstract provided.

The Efficacy And Acceptability Of A Virtual Versus Hybrid Wellness Program On Health Outcomes Among Faculty And Staff At A Northeastern University During Covid-19, Elizabeth Tenison

Graduate Research Theses & Dissertations

According to American Psychological Association Work and Well-being Survey of 1,501 U.S. adult workers, 79% of employees reported negative impacts of work-related stress, including lack of interest (26%) and effort (19%) at work. Workplace wellness programs offer a means to alleviate stress among employees. The research explored the perceived acceptability and efficacy of a virtual versus hybrid wellness program and some specific health outcomes, total cholesterol, BP, and BMI, perceived well-being and stress among faculty and staff at a northeastern university. Participants (n=61) included women (77%), 30-50 years of age (67.7%), and staff (30%) vs. faculty (70%) enrolled in the …

Underlying Factors Of Laboratory Safety Behaviors In College Students Using The Theory Of Planned Behavior And Risk Perceptions, Michele M. Crase

Graduate Research Theses & Dissertations

Laboratory safety in academic settings has long been a concern for colleges and universities worldwide. Education and training for lab safety is often a one size fits all process. That is, the same training given to faculty and staff is also given to students. However, students are generally younger, less educated and less experienced than faculty or staff. To better understand the students’ educational needs related to lab safety, it was important to understand their attitudes toward safety behaviors and perceived risks of hazards in a lab. To confound matters, the COVID-19 pandemic added another level of concern regarding personal …

Ser-109: An Oral Investigational Microbiome Therapeutic For Patients With Recurrent Clostridioides Difficile Infection (Rcdi), Sahil Khanna, Sims, Thomas J. Louie, Monika Fischer, Kerry L. Laplante, Jessica Allegretti, Brooke R. Hasson, Allyson T. Fonte, Christopher Mcchalicher, David S. Ege, Jessica A. Bryant, Timothy J. Straub, Christopher B. Ford, Matthew R. Henn, Elaine E.L. Wang, Lisa Von Moltke, Mark H. Wilcox

Pharmacy Practice and Clinical Research Faculty Publications

Clostridioides difficile infection (CDI) is classified as an urgent health threat by the Centers for Disease Control and Prevention (CDC), and affects nearly 500,000 Americans annually. Approximately 20–25% of patients with a primary infection experience a recurrence, and the risk of recurrence increases with subsequent episodes to greater than 40%. The leading risk factor for CDI is broad-spectrum antibiotics, which leads to a loss of microbial diversity and impaired colonization resistance. Current FDA-approved CDI treatment strategies target toxin or toxin-producing bacteria, but do not address microbiome disruption, which is key to the pathogenesis of recurrent CDI. Fecal microbiota transplantation (FMT) …

Generalizing Trial Evidence To Target Populations In Non-Nested Designs: Applications To Aids Clinical Trials, Fan Li, Ashley L. Buchanan, Stephen R. Cole

Pharmacy Practice and Clinical Research Faculty Publications

Comparative effectiveness evidence from randomized trials may not be directly generalizable to a target population of substantive interest when, as in most cases, trial participants are not randomly sampled from the target population. Motivated by the need to generalize evidence from two trials conducted in the AIDS Clinical Trials Group (ACTG), we consider weighting, regression and doubly robust estimators to estimate the causal effects of HIV interventions in a specified population of people living with HIV in the USA. We focus on a non-nested trial design and discuss strategies for both point and variance estimation of the target population average …

Understanding The Effects Of Ligand Environment On Important Properties Of Redox-Active Europium Using Computational Chemistry And T1-Weighted Magnetic Resonance Imaging, Brooke Anne Corbin

Wayne State University Dissertations

This thesis is a collection of seven chapters that describes a combination of literature research and experimental analyses into the study of inorganic complexes, with an emphasis on the photophysics and coordination of redox-active europium. The first chapter summarizes the key features of each chapter. The second and third chapters are detailed overviews, including historical context, current studies, and future goals of imaging science, with an emphasis on inorganic complexes. The fourth chapter describes the design of a screening procedure to study new ligand environments for redox-active europium using magnetic resonance imaging and a proof-of-concept experiment. The fifth chapter is …

Segmentation Of Intracranial Structures From Noncontrast Ct Images With Deep Learning, Evan Porter

Wayne State University Dissertations

Presented in this work is an investigation of the application of artificially intelligent algorithms, namely deep learning, to generate segmentations for the application in functional avoidance radiotherapy treatment planning. Specific applications of deep learning for functional avoidance include generating hippocampus segmentations from computed tomography (CT) images and generating synthetic pulmonary perfusion images from four-dimensional CT (4DCT).A single institution dataset of 390 patients treated with Gamma Knife stereotactic radiosurgery was created. From these patients, the hippocampus was manually segmented on the high-resolution MR image and used for the development of the data processing methodology and model testing. It was determined that …

The Lived Experiences Of Muslim Women With Infertility, Samia Abdelnabi

Wayne State University Dissertations

Background: Infertility, ranked as the 5th highest global disability, is estimated to impact 180 million couples worldwide. Muslim couples associate parenthood or the ability to have children as an accomplishment in their marriage, adulthood, social status, and security in later life. A failure to conceive in Muslim societies may lead to stigma, social isolation, grief, and despair. There is a gap in the literature on how Muslim women perceive, understand, and cope with infertility in the U.S. This knowledge gap limits the ability in to understand how social, religious, and cultural practices impact a diagnosis of infertility on Muslim American …

Role Of Aldehyde Dehydrogenase 2 (Aldh2) In The Decrease In Coronary Angiogenesis In Type 2 Diabetes Mellitus: Identifying Novel Signaling Pathways, Bipradas Roy

Wayne State University Dissertations

Coronary endothelial cell (CECs) damage and rarefaction of coronary microvasculature are implicated in diabetes-induced heart failure with preserved ejection fraction (HFpEF). 4-hydroxy-2-nonenal (4-HNE), a reactive aldehyde that is increased in diabetic hearts, contributes to CEC dysfunction and cardiotoxicity. Aldehyde dehydrogenase (ALDH) 2, a mitochondrial enzyme that detoxifies 4-HNE and confers cardioprotection. However, ALDH2 activity is decreased in diabetic hearts, which results in the augmentation of 4HNE-induced cardiotoxicity. Thus, we hypothesize that activation of ALDH2 in CECs reduces 4-HNE-mediated cell signaling aberrations and preserves coronary angiogenesis. We employed cell culture studies and animal models to test our hypothesis. In our cell …

Kinase-Catalyzed Labeling To Identify Kinase-Substrate Pairs Using Γ-Phosphate Modified Atp Analogs, Rachel Beltman

Wayne State University Dissertations

Post-translational modifications (PTMs) are responsible for a variety of cellular processes. One such PTM is protein phosphorylation, which is catalyzed by kinases. Kinase enzymes play important roles in cellular signaling pathways, but dysregulation of kinase-mediated events results in the formation of diseases, which make kinases favorable drug targets. To uncover the role kinases play in the development of diseases, kinase-mediated cellular events need to be better understood. The current gap in the field is the lack of tools available to identify the kinase that is responsible for specific phosphorylation events within the cell. To improve the gap in the field, …

Novel Interaction Of Cxcr4 And Pi4kiiiα In Prostate Cancer, Barani Govindarajan

Wayne State University Dissertations

The CXCR4-CXCL12 chemokine signaling axis plays a key role in migration and bone metastasis in prostate cancer (PC). Androgens regulate CXCR4 expression and its receptor activation in lipid-raft micro domains of PC cells, resulting in higher protease expression and invasion. In order to identify some novel CXCR4 co-regulators associated within the lipid-raft, a SILAC (Stable isotope labeling using amino acid in cell culture)-based proteomic analysis was performed with PC3 stable cell-lines over-expressing or knocking-down CXCR4. Phosphatidylinositol 4-kinase III alpha (PI4KIIIα or PI4KA) and SAC1 lipid phosphatase were identified as candidate proteins enriched in CXCR4 expressing cells. PI4KA is an evolutionarily …

Sequences Of Random Matrices Modulated By A Discrete-Time Markov Chain, Huy Nguyen

Wayne State University Dissertations

In this dissertation, we consider a number of matrix-valued random sequences that are modulated by a discrete-time Markov chain having a finite space.Assuming that the state space of the Markov chain is large, our main effort in this work is devoted to reducing the complexity. To achieve this goal, our formulation uses time-scale separation of the Markov chain. The state-space of the Markov chain is split into subspaces. Next, the states of the Markov chain in each subspace are aggregated into a ``super'' state. Then we normalize the matrix-valued sequences that are modulated by the two-time-scale Markov chain. Under simple …

Small G- Protein Regulators Of Islet Beta Cell Function, Suhadinie Sameera Gamage

Wayne State University Dissertations

Defects in insulin secretion from pancreatic islet beta- cells leads to long term complications such as type 2 diabetes mellitus. The mechanism and regulation of glucose stimulated insulin secretion (GSIS) as well as factors contributing to pancreatic islet beta-cell demise are yet poorly understood. Previous work from our laboratory demonstrated that Ras-related C3 botulinum toxin substrate 1 (Rac1), a small G- protein is involved in GSIS as well as in culminating dysfunction under metabolic stress. Cycling of Rac1 between its inactive and active form is considered a vital event in glucose stimulated insulin secretion. This conversion is made possible by …

Exploring Structural Differences Between Antagonistic Peptides For The Development Of Orally Bioavailable Pcsk9 Inhibitors, Bhavya Soni, Pritika Vemulapalli

Protein Modeling Reports

Familial hypercholesterolemia (FH) is an autosomal genetic disease that causes elevated blood levels of low-density lipoprotein (LDL). One of the leading causes of FH is gain-of-function mutations in the gene coding for proprotein convertase subtilisin/kexin type 9 (PCSK9). The PCSK9 protein binds to LDL receptors (LDLR) on the surface of hepatocytes and promotes their degradation, preventing the recycling of LDLRs and thus increasing LDL blood levels. Monoclonal antibody therapies that bind to PCSK9 inhibiting LDLR binding are currently only available as an injection. However, several orally bioavailable PCSK9 inhibitors have been formulated and are undergoing clinical trials. One such therapy …

Community-Based Accompaniment For Adolescents Transitioning To Adult Hiv Care In Urban Peru: A Pilot Study, Valentina Vargas, Milagros Wong, Carly A. Rodriguez, Hugo Sanchez, Jerome T. Galea, Alicia Ramos, Liz Senador, Lenka Kolevic, Eduardo Matos, Eduardo Sanchez, Renato A. Errea, Karen Ramos, Catherine Beckhorn, Andrew Lindeborg, Carlos Benites, Leonid Lecca, Sonya Shin, Molly F. Franke

Social Work Faculty Publications

We piloted a community-based intervention to improve outcomes among adolescents living with HIV who were transitioning to adult-oriented care in Lima, Peru. We assessed feasibility and potential effectiveness, including within-person changes in self-reported adherence, psychosocial metrics (NIH Toolbox), and transition readiness (“Am I on TRAC” questionnaire, “Got Transition” checklist). From October 2019 to January 2020, we enrolled 30 adolescents (15–21 years). The nine-month intervention consisted of logistical, adherence and social support delivered by entry-level health workers and group sessions to improve health-related knowledge and skills and social support. In transition readiness, we observed within-person improvements relative to baseline. We also …

Investigating The Antibacterial Activity Of Novel Metal Complexes Against Antimicrobial Resistant Pathogens, Megan O'Shaughnessy

Theses, Doctoral

Antimicrobial resistance (AMR) is one of the serious global health challenges of our time. There is an urgent need to develop novel therapeutic agents to overcome AMR, preferably through alternative mechanistic pathways from conventional treatments. Interdisciplinary research in inorganic medicinal chemistry with biology is advancing the knowledge and implementation of transition metal complexes for therapy and is offering a realistic alternative to traditional antibiotics. Metal complexes with 1,10-phenanthroline (phen) ligands have demonstrated promising therapeutic capabilities with diverse biological activity. Consequently, there has been a resurgence in research of these complexes as possible alternatives or adjuvants to established antimicrobial clinical therapeutics. …

South Dakota State University Undergraduate Catalog 2022-2023, South Dakota State University

South Dakota State University Catalogs and Bulletins: 1935 to present

No abstract provided.

Using The Protection Motivation Theory To Understand The Mental Health Impact Of Surviving Covid-19, Kaprea Johnson, Angel Spence, Yousef Sherif, Dana Brookover, Adrienne White

Adultspan Journal

Due to the widespread effects of COVID-19, mental health professionals need to understand the lived experiences of survivors. Data were collected from YouTube videos (N = 52), which contained firsthand perspectives from COVID-19 survivors. Survivors understood the high stakes of COVID-19, reported the dual threat to physical and mental health, entered “survival mode,” and had both positive and negative reflections on the experience. Implications for mental health professionals and future research directions are included.

Catalog | 2022-2023, Jacksonville State University

Announcements, Bulletins & Catalogs | Undergraduate

(2022-2023). In its early years as the State Normal School, JSU produced a variety of publications (announcements, bulletins, and catalogs) that contain course information combined with the types of information that would later be found in yearbooks. Examples include historical information about the school, lists of enrolled students and club officers, photographs of athletic teams and literary clubs, notes on alumni, faculty and campus facilities, and more.

Educational Initiative In An Ncats Tl1 Training Program To Address The Impact Of Systemic Racism On Human Health, Biomedical Research, And The Translational Scientist, Martha D. Gay, Kimberly A. Bell, Emily A. Bujold, Marilla Geraci, Dexter L. Lee, Kathryn Sandberg, Robert C. Speth

HPD Articles

INTRODUCTION: The goal of clinical and translational science (CTS) is to fill gaps in medical knowledge toward improving human health. However, one of our most pressing challenges does not reside within the biological map we navigate to find sustainable cures but rather the moral compass to recognize and overcome racial and ethnic injustices that continue to influence our society and hinder diverse research rigor. The Georgetown-Howard Universities Center for Clinical and Translational Science includes an inter-institutional TL1-funded training program for predoctoral/postdoctoral trainees in Translational Biomedical Science (TBS). METHODS: In the fall of 2020, the TBS program responded to the national …

Of Law And Men, @Badgaltranny -

JCLC Online

This article was written in conjunction with the 2021-2022 Journal of Criminal Law and Criminology Symposium: Do Hate Crime Laws #stophate, #stophatecrimes, and #standagainstthehate? that occurred on April 8, 2022.

I, an Indian-American transgender woman, share stories of my sexual escapades with seven Trump supporters to move us towards new mountains in jurisprudential scholarship. I do so with the hope that my stories will expose some long-sunken truths (truths perhaps buried by our own law schools) about the human desires which drive people to police, and democracies to dominions.

The rabid protestations of Law Professor Storyhaters, triggered by the …

Biomedical Applications Of Lanthanide Nanomaterials, For Imaging, Sensing And Therapy, Qize Zhang, Stephen O'Brien, Jan Grimm

Publications and Research

The application of nanomaterials made of rare earth elements within biomedical sciences continues to make significant progress. The rare earth elements, also called the lanthanides, play an essential role in modern life through materials and electronics. As we learn more about their utility, function, and underlying physics, we can contemplate extending their applications to biomedicine. This particularly applies to diagnosis and radiation therapy due to their relatively unique features, such as an ultra-wide Stokes shift in the luminescence, variable magnetism and potentially tunable properties, due to the library of lanthanides available and their multivalent oxidation state chemistry. The ability to …

News - Special Issue On Bilingual Pedagogy At Utrgv, The University Of Texas Rio Grande Valley. Corpus Bilingüe Del Valle

Corpus Bilingüe del Valle (CoBiVa) - News Releases

No abstract provided.

The Evolution And Morphological Change In Keratella Cochlearis, Semra Dervisevic

Undergraduate Research Posters 2022

Organisms in the phylum Rotifera are vital for freshwater environments; they have a short development time, fast turnover, high production, circulate organic matter, and aid in energy transfer (Li, Cheng, & Chen, 2005). However, they are becoming increasingly difficult to characterize by molecular studies due to cryptic genetic differences that are not reflected in their morphology. This is due to the sensitivity based on responses to environmental parameters such as water temperature and chemical cues from predators (Stemberger & Gilbert 1984, Green 2005). This arises the need to identify the presence and geographic distribution of cryptic species complexes; this study …

The Impact Of Soil Compaction On Soil Moisture Dynamics Of Red Maple, Norway Maple, And Honey Locust Tree Species In Urban Environments, Cyenna Ulrich-Cech

Undergraduate Research Posters 2022

Soil compaction, a result of urbanization, may be detrimental to the soil moisture dynamics and health of urban trees which subsequently limits their ecosystem services. This study considers two hypotheses: higher compacted soils will negatively impact soil moisture dynamics of red maple, Norway maple, and honey locust tree species on campus; and there will be a difference in the soil moisture dynamics between tree species due to varying tree traits. A preliminary survey was conducted on trees of interest to gather health metric data, and soil compaction, soil texture, and water holding capacity were measured. Additionally, soil moisture measurements were …

Unm Pathology Pathfinder Winter 2022, Unm Department Of Pathology

Newsletters

No abstract provided.

Psychedelic Therapies At The Crossroads Of Trauma And Substance Use: Historical Perspectives And Future Directions, Taking A Lead From New Mexico, Snehal R. Bhatt, Maya Armstrong, Tassy Parker, Marcello Maviglia, Rebecca Kass, Lawrence Leeman, Paul Romo, Douglas Ziedonis

Family and Community Medicine Research and Scholarship

Post-traumatic stress disorder (PTSD), a common condition with potentially devastating individual, family, and societal consequences, is highly associated with substance use disorders (SUDs). The association between PTSD and SUD is complex and may involve adverse childhood experiences (ACEs), historical and multi-generational traumas, and social determinants of health as well as cultural and spiritual contexts. Current psychosocial and pharmacological treatments for PTSD are only modestly effective, and there is a need for more research on therapeutic interventions for co-occurring PTSD and SUD, including whether to provide integrated or sequential treatments. There is a current resurgence of interest in psychedelics as potential …

Investigating Mechanistic Pathways Involved In Neuroimmune Dysregulation And Neuropathic Pain Susceptibility Due To Prenatal Alcohol Exposure, Ariana Pritha, Joshua J. Sanchez, Jacob E. Sanchez, Suzy Davies, Daniel D. Savage, Nikolaos Mellios, Shahani Noor, Erin D. Milligan

Brain & Behavioral Health Research Day

Neuropathic pain is a chronic pain condition resulting from damaged peripheral nerves that induces allodynia (pathological touch sensitivity). Our previous studies suggest that prenatal alcohol exposure (PAE) is a risk factor for allodynia. In contrast to control rats, adult PAE rats with minimal nerve injury develop allodynia. Nerve-injured PAE rats display heightened peripheral and central nervous system (CNS) immune cell-derived proinflammatory cytokine production that consequently results in allodynia. This suggests that PAE dysregulates peripheral immune and CNS glial cell function to over-respond to subtle immune challenges leading to allodynia. However, gene expression profiles underlying dysregulated neuroimmune activity due to PAE …