Digital Commons Network^™

Survivor's Guide To Probate & Trust Administration, Indiana Continuing Legal Education Forum (Iclef)

Indiana Continuing Legal Education Forum 2022

Meeting proceedings of a seminar by the same name, held November 18, 2022

Western Herbalism: What Drives Individuals Within Rhode Island To Study This Ancient Healing Modality?, Kyla Shea

Student Publications

People globally rely on herbal practices as their main form of healing, yet few people in the West understand how to properly identify and effectively use herbs. This loss of knowledge regarding traditional healing practices was done so intentionally during enslavement and colonization, resulting in exploitation and misinterpretation of herbal practices. By reclaiming this knowledge, it is not only a way to improve the health of communities and the land, but it is also a way of reclaiming ancestral traditions and connection with oneself. Furthermore, this research paper explores the complexities of Western herbalism and determines what drives individuals within …

University Of Richmond Magazine - Winter 2022

University of Richmond Magazine

The University of Richmond's Alumni Magazine was first published as The Alumni Bulletin in 1936 and continues to this day as the University of Richmond Magazine.

University Of Richmond Magazine - Spring/Summer 2022

University of Richmond Magazine

The University of Richmond's Alumni Magazine was first published as The Alumni Bulletin in 1936 and continues to this day as the University of Richmond Magazine.

What Is More Effective: Corticosteroid Injections Or Platelet Rich Plasma Infections In The Treatment Of Lateral Epicondylitis?, Joseph Mohr, Curt Stilp, Justin Gambini

Doctor of Medical Science (DMSc)

ABSTRACT

Lateral epicondylitis is a common degenerative tendinopathy that affects a wide variety of individuals. One patient population that often suffers more than others are workers with manual labor jobs that use vibrating tools and repetitive motions.1 Procedural costs and disease burden associated with lateral epicondylitis have increased in recent years.3 Current treatment of lateral epicondylitis using corticosteroid injections is beginning to fall out of favor. Corticosteroid injections help decrease inflammation; however, research looking into the histology of lateral epicondylitis favors more of a degenerative tendinopathy rather than an inflammatory condtion.1 In addition, several studies have found corticosteroid injections to …

Undergraduate Catalogue 2022-2023, Seton Hall University

Undergraduate Catalogues

No abstract provided.

Uni Alumni Magazine, Issue 04, 2022, University Of Northern Iowa Alumni Association

UNI Alumni Magazine

Contents:

Building better communities --- 6
Depths of discovery --- 8
Keeping students safe --- 16
El valor de la representación --- 22
Transforming lives --- 26
Racing to the future --- 28
Celebrating Black entrepreneurs --- 30
Project planet --- 32
Saving a species --- 36
Preserving faith --- 42
Stopping a virus --- 48
Purpose over profits --- 52
Campus news --- 56
Class notes --- 58

Destination Dental School: A Remote Pipeline Program To Increase Student Diversity, Thikriat Al-Jewair Dds, Ms, Frcd(C), Jessica Scates Med

The New York State Dental Journal

Promoting diversity among dental school applicants and enrollees is key to tackling oral health disparities and improving learning outcomes. Building the pipeline has proven to be an effective method to increase diversity and heighten interest in dentistry among students. Destination Dental School is an 8-week remote pipeline program aimed at increasing diversity of historically underrepresented minority (HURM) students in the field of dental medicine. Pre- and post-program surveys showed that the program was effective in fostering HURM students’ interest in dentistry and increasing their knowledge and preparedness for dental school applications.

Response 2022, Seattle Pacific University

Seattle Pacific Alumni Magazines

No abstract provided.

Protonation And Non-Innocent Ligand Behavior In Pyranopterin Dithiolene Molybdenum Complexes, Cassandra Gates, Haley Varnum, Catherine Getty, Natalie Loui, Ju Chen, Martin L. Kirk, Jing Yang, Sharon J. Nieter Burgmayer

Chemistry Faculty Research and Scholarship

The complex [TEA][Tp*MoIV(O)(S2BMOPP)] (1) [TEA = tetraethylammonium, Tp* = tris(3,5-dimethylpyrazolyl)hydroborate, and BMOPP = 6-(3-butynyl-2-methyl-2-ol)-2-pivaloyl pterin] is a structural analogue of the molybdenum cofactor common to all pyranopterin molybdenum enzymes because it possesses a pyranopterin-ene-1,2-dithiolate ligand (S2BMOPP) that exists primarily in the ring-closed pyrano structure as a resonance hybrid of ene-dithiolate and thione-thiolate forms. Compound 1, the protonated [Tp*MoIV(O)(S2BMOPP-H)] (1-H) and one-electron-oxidized [Tp*MoV(O)(S2BMOPP)] [1-Mo(5+)] species have been studied using a combination of electrochemistry, electronic absorption, and electron paramagnetic resonance (EPR) spectroscopy. Additional insight into the nature of these molecules has been derived from electronic structure computations. Differences in dithiolene C–S bond …

Ferrihydrite Enrichment In The Rhizosphere Of Unsaturated Soil Improves Nutrient Retention While Limiting Arsenic And Uranium Plant Uptake, Arindam Malakar, Daniel D. Snow, Michael Kaiser, Jordan Shields, Bijesh Maharjan, Harkamal Walia, Daran Rudnick, Chittaranjan Ray

Nebraska Water Center: Faculty Publications

Improvement of nutrient use efficiency and limiting trace elements such as arsenic and uranium bioavailability is critical for sustainable agriculture and food safety. Arsenic and uranium possess different properties and mobility in soils, which complicates the effort to reduce their uptake by plants. Here, we postulate that unsaturated soil amended with ferrihydrite nanominerals leads to improved nutrient retention and helps reduce uptake of these geogenic contaminants. Unsaturated soil is primarily oxic and can provide a stable environment for ferrihydrite nanominerals. To demonstrate the utility of ferrihydrite soil amendment, maize was grown in an unsaturated agricultural soil that is known to …

Lawrence, Fall/Winter 2022, Lawrence University

Alumni Magazines

No abstract provided.

What’S A Guanaco?: Tracing The Llama Diaspora Through And Beyond South America, Emily Wakild

History Faculty Publications and Presentations

Let us begin with Spook the llama. Spook lived in the animal enclosures at New York’s Central Park Zoo in 1912. Caretakers described Spook as a “morose, cantankerous” soul inhabiting the back of the deer range. Initially forlorn by this location, he looked out the back door at the road that circled past the pen. The busy street proved entertaining as it was full of noisy automobiles and anxious drivers honking. Spook watched the cars and, before long, learned to honk. Or so reported the head keeper at the zoo, Bill Snyder, who claimed “Spook thrust his head forward, drew …

Mechanisms Of Progestin Resistance In Reproductive-Age Women With Atypical Endometrial Hyperplasia, Katherine Mcmaster Cooke

Yale Medicine Thesis Digital Library

With the rising prevalence of endometrial cancer and its precursor atypical hyperplasia (AH) in reproductive-age women amid the obesity epidemic, understanding the pathogenesis of this disease process is crucial to improving medical management. We sought to identify factors that may contribute to progestin-resistant AH via analysis of clinical data as well as investigation of hormonal regulation of endometrial gene and protein expression. We conducted a retrospective review of women with AH (n=63) compared to those with benign hyperplasia (BH) (n=73), which has a significantly lower risk of progression to malignant disease. Subsequently, we analyzed a sub-cohort of women with progestin-responsive …

Outpatient Physical Therapy Management Of A Patient With Low Tone And Developmental Delay: A Case Study, Ana Braaten

Physical Therapy Scholarly Projects

Background and Purpose: Developmental delay is when a child does not reach a developmental milestone by the expected age. Low tone is when there is poor muscle strength. This case study evaluates the effectiveness of conservative physical therapy care as a treatment for low tone and developmental delay. The study also discusses the patient’s outcomes based on the chosen interventions. These results can be used to further understand the most efficacious interventions for low tone and developmental delay treatment.

Case Description: The patient was a 9-month-old male referred by his primary care provider for low tone and developmental delay.

Interventions: …

Benjamin Percy And Queer Ecomasculinities: Ideas Of The Short Story From Hemingway To The Present, Thomas Edward Hahn

Theses and Dissertations

The 21st Century has ushered in a need to problemetize and challenge traditional boundaries between social and philosophical realms. It is therefore more important now than ever to revisit the classification of literary genres, specially the short story. Through the intersection of queer, literary, and ecocritical theory, this book reexamines the current identity of the contemporary American short story in order to posit that it is a queer formation, a hybrid of both the novel and the poem, among the generic literary landscape. Through this queer literary form, the short story subsequently has the ironic potential to reveal insight into …

Stormwater Capture Via Green Infrastructure In The Plaster Creek Watershed, Naomi Dykstra, Noah Millen, Ethan Tulp, Josian Aardema, Deanna Geelhoed, David Warners

Summer Research

Calvin University’s campus is located within the Plaster Creek watershed, an area of land from Caledonia to the Grand River, near downtown Grand Rapids. After many years of neglect and mistreatment, it has become one of the most polluted waterways in West Michigan. Plaster Creek Stewards (PCS) aims to improve the local watershed by focusing on education, research and restoration projects. These projects help through reduction of stormwater runoff containing high amounts of sediment and other pollutants through the use of green infrastructure.

Refugia Gardening: A Good Anthropocene Begins At Home, Robin Kollar, David S. Koetje

Summer Research

Our present age is often called the Anthropocene, an era dominated by human activities that erode biodiversity and ecological functions, altering natural systems and cycles. As a result, we are causing climate and mass extinction crises and undermining the ecosystem services that enable human flourishing. Thus, humans have moral and existential obligations to reverse this trend by realigning our relationships with nature. We are advocating for refugia gardening to build places of renewal in our own yards and in our communities. Refugia are pockets of life where species can survive and adapt during ecological crises. Refugia become “seeds” for repopulating …

Mutations Linked To Rare Diseases Can Be Generated And Tested In Zebrafish, Brianna Jansen, Luke Schipper, Valeria Lacroix, Amy Wilstermann, Rachael Baker

Summer Research

• BCS1L is important for cellular respiration and located in the mitochondria.
• Mutations in BCS1L cause a wide variety of symptoms leading to 3 rare diseases.

The Emma Cole Project: Reevaluating The Flora Of Grand Rapids, William Hofmann, Hayden Janssen, Martin Vanderschoot, David Warners

Summer Research

In 1901, botanist and teacher Emma Cole published an account of all the vascular plants in the Grand Rapids area, which is the most comprehensive documentation of the flora in the area today. The vicinity of Grand Rapids has been developed significantly since then, and with it the surrounding natural spaces have also been greatly altered. Over the past 7 years, Calvin University’s Emma Cole Project has been inventorying the flora of greater Grand Rapids and comparing modern plant life with the flora during Cole’s time 120 years ago. This project strives to both verify species’ presence around Grand Rapids …

Modelling Quinones Using Density Functional Theory, David Ruiter, Madeleine Callan, Elijah Gruszecki, Maya Nambisan, Dr. K. V. Lakshmi

Summer Research

We modelled benzoquinone (BQ), dichlorobenzoquinone (DCBQ), and dimethylbenzoquinone (DMBQ) using the ORCA quantum chemistry computation suite. We obtained singlepoint energies, electron and spin densities, and the hyperfine coupling values for each molecule suspended in dimethyl sulfoxide (DMSO) and isopropyl alcohol (IPA). In most cases, we find close agreement with published literature values.

Preferential Infection Of Ccr6+ Cd4+ T Cells By Hiv Is Increased By Human Intestinal Endothelial Cells, Fisher Pham, Jessica Eddy, Nathan Dapprich, Anding Shen

Summer Research

Th17 cells are found to be heavily depleted in the gut of HIV patients. Even after successful antiretroviral therapy, HIV patients exhibit a smaller Th17 population for years after treatment. Previous research has found human intestinal endothelial cells (IEC) to increase HIV infection of helper T cells. Using CCR6 as a marker for Th17, we investigated the effect of IEC on HIV infection of Th17 cells. IECs were found to increase the preferential infection of resting and activated CCR6+ cells. Th17 cells are known to be more susceptible to HIV infection than other types of CD4+ T cells. IEC stimulation …

Cysteine-Tyrosine Crosslink Synthesis In Bf4112 From B. Fragilis, Alex Van Uffelen, Sophie Hruska, David Benson

Summer Research

Redox-active crosslinked amino acids are a class of post-translational modifications that extend protein chemistry. These cofactors occur in fifteen known proteins with high resolution Xray crystallography as the primary method for confirmation. One of those proteins is cytochrome c oxidase (complex IV), where HisTyr (figure 1) is responsible for the high-valent oxidative intermediate in O2 reduction to 2H2O. Cys-Tyr was the first of these cofactors to be identified and is characterized in galactose oxidase (coordinated to a Cu ion) and cysteine dioxygenase (distal to a mononuclear non-heme iron ion).

Water Assessment Of Plaster Creek, Lynda Steen, C.D. Tatko

Summer Research

Plaster Creek is a polluted water system in western Michigan that displays a variety of contaminants. Calvin University sits fully withing the Plaster Creek watershed, increasing its relevancy and importance. The Plaster Creek Stewards have a history of working to improve the quality of water and educate residents regarding their impact on the creek. Within the Silver Creek tributary there have been a number of interventions involving the reintroduction of native plant life and altering the creek's path when daylighting. The nutrient load of Silver Creek is important to both the water quality and biological thriving. The chemical analysis herein …

Munson Hall, Central Washington University

What is in a Name?

No abstract provided.

Cardiovascular Applications Of Artificial Intelligence In Research, Diagnosis, And Disease Management, Viswanathan Rajagopalan, Houwei Cao

Center for No Boundary Thinking

Despite significant advancements in diagnosis and disease management, cardiovascular (CV) disorders remain the No. 1 killer both in the United States and across the world, and innovative and transformative technologies such as artificial intelligence (AI) are increasingly employed in CV medicine. In this chapter, the authors introduce different AI and machine learning (ML) tools including support vector machine (SVM), gradient boosting machine (GBM), and deep learning models (DL), and their applicability to advance CV diagnosis and disease classification, and risk prediction and patient management. The applications include, but are not limited to, electrocardiogram, imaging, genomics, and drug research in different …

Cbp60-Db: An Alphafold-Predicted Plant Kingdom-Wide Database Of The Calmodulin-Binding Protein 60 (Cbp60) Protein Family With A Novel Structural Clustering Algorithm, Keaun Amani, Vanessa Shivnauth, Christian Castroverde

Biology Faculty Publications

Molecular genetic analyses in the model species Arabidopsis thaliana have demonstrated the major roles of different CAM-BINDING PROTEIN 60 (CBP60) proteins in growth, stress signaling, and immune responses. Prominently, CBP60g and SARD1 are paralogous CBP60 transcription factors that regulate numerous components of the immune system, such as cell surface and intracellular immune receptors, MAP kinases, WRKY transcription factors, and biosynthetic enzymes for immunity-activating metabolites salicylic acid (SA) and N-hydroxypipecolic acid (NHP). However, their function, regulation and diversification in most species remain unclear. Here we have created CBP60-DB, a structural and bioinformatic database that comprehensively characterized 1052 CBP60 gene homologs …

Sars-Cov-2 Dysregulates Neutrophil Degranulation And Reduces Lymphocyte Counts, Abenaya Muralidharan, Todd A. Wyatt, St. Patrick Reid

Journal Articles: Environmental, Agricultural & Occupational Health

SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19 patients. However, the mechanisms underlying this clinical outcome and the reasons for its correlation to poor prognosis are unclear. Furthermore, the mechanisms involved in healthy neutrophils acquiring a SARS-CoV-2-mediated detrimental role are yet to be fully understood. In this study, we isolated circulating neutrophils from healthy donors for treatment with supernates from infected epithelial cells and direct infection with SARS-CoV-2 in vitro. Infected epithelial cells …

Aldehyde Trapping By Adx-102 Is Protective Against Cigarette Smoke And Alcohol Mediated Lung Cell Injury, Carmen A. Ochoa, Claire Nissen, Deanna Mosley, Christopher Bauer, Destiny Jordan, Kristina L. Bailey, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Most individuals diagnosed with alcohol use disorders smoke cigarettes. Large concentrations of malondialdehyde and acetaldehyde are found in lungs co-exposed to cigarette smoke and alcohol. Aldehydes directly injure lungs and form aldehyde protein adducts, impacting epithelial functions. Recently, 2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol (ADX-102) was developed as an aldehyde-trapping drug. We hypothesized that aldehyde-trapping compounds are protective against lung injury derived from cigarette smoke and alcohol co-exposure. To test this hypothesis, we pretreated mouse ciliated tracheal epithelial cells with 0–100 µM of ADX-102 followed by co-exposure to 5% cigarette smoke extract and 50 mM of ethanol. Pretreatment with ADX-102 dose-dependently protected against smoke and …

Surface Modification Of Biodegradable Microparticles With The Novel Host-Derived Immunostimulant Cpdi-02 Significantly Increases Short-Term And Long-Term Mucosal And Systemic Antibodies Against Encapsulated Protein Antigen In Young Naïve Mice After Respiratory Immunization, Jacob E. Parriott, Jason P. Stewart, D. David Smith, Stephen M. Curran, Christopher D. Bauer, Todd A. Wyatt, Joy A. Phillips, Elizabeth Lyden, Geoffrey M. Thiele, Joseph A. Vetro Phd

Journal Articles: Environmental, Agricultural & Occupational Health

Generating long-lived mucosal and systemic antibodies through respiratory immunization with protective antigens encapsulated in nanoscale biodegradable particles could potentially decrease or eliminate the incidence of many infectious diseases, but requires the incorporation of a suitable mucosal immunostimulant. We previously found that respiratory immunization with a model protein antigen (LPS-free OVA) encapsulated in PLGA 50:50 nanoparticles (~380 nm diameter) surface-modified with complement peptide-derived immunostimulant 02 (CPDI-02; formerly EP67) through 2 kDa PEG linkers increases mucosal and systemic OVA-specific memory T-cells with long-lived surface phenotypes in young, naïve female C57BL/6 mice. Here, we determined if respiratory immunization with LPS-free OVA encapsulated in …