Digital Commons Network^™

Exploring Gaps In Understanding And Responding To Ageism: A Conceptual Model, Psychosocial Health, And Racialized Ageism, Andrew T. Steward

Electronic Theses and Dissertations

Ageism is an insidious, prevalent social justice issue which has harmful effects on the health of older adults. This dissertation includes three manuscripts which explore gaps in understanding and responding to ageism through three distinct methodological approaches. Two primary gaps are addressed in the three manuscripts: 1) conceptualizing and testing activities or interventions to reduce internalized ageism and enhance psychosocial health for older adults, and 2) exploring the intersectionality of ageism with racism.

The first manuscript draws from stereotype embodiment theory and theories of successful and productive aging to detail a conceptual model of interventions which may reduce internalized ageism …

Education Finance As A Social Determinant Of Health In The United States, Sydney Mock

Electronic Theses and Dissertations

The purpose of this thesis is to investigate the role of K-12 education finance in the determination of health outcomes in the United States. To accomplish this, first, the differing theoretical perspectives surrounding health outcomes are explored. Second, theoretical literature surrounding public finance of education and cash vs in-kind benefits are explored to establish the grounds for connecting education finance and health. Third, a framework is presented to trace the pathways of how education finance determines health outcomes. Finally, the manuscript brings together a review of the literature on similar benefits and an evaluation of a voucher program in Cleveland, …

The Examination Of Social Support Received After Traumatic Experiences, Emily Abellon

Electronic Theses and Dissertations

This study aimed to explore what constitutes effective and ineffective social support after an individual endures trauma. Participants were recruited mainly through social media to complete an online survey with open-ended questions. The survey provided participants with the opportunity to reflect and share the social support they received after the endured trauma, specifically disclosing what support messages were effective and ineffective, and why these messages were effective and ineffective. The messages found to be effectively supportive after the endured trauma, and the ones most frequently mentioned were emotional and appraisal support. These messages were found to be effective due to …

Examining Relationships Among Creativity Skills Training, Domain-Specific Creativity, And Creative Self-Efficacy: A Mixed Methods Study, Kayla R. Steffens

Electronic Theses and Dissertations

The purpose of this study is to examine the relationships among and impact of creativity skills training, domain-specific creativity, and creative self-efficacy in adult alumni of a youth creativity skills training experience. This research further aims to remediate the deficiency of existing creativity research regarding the relationship between domain-specific creativity, creativity skills training, and creative self-efficacy. This study employs a mixed-method approach to address four research questions regarding the impact of a creativity skills training experience from adult alumni of Destination Imagination, an educational experience designed to enhance creativity. The Amusement Park Theoretical Model of Creativity acts as a theoretical …

Are You My Nurse? The Effects Of Patient-Delivered Gender Microaggressions On Women Trainees’ Clinical Work In Integrated Primary Care, Julia Ratchford Kauffmann

Electronic Theses and Dissertations

Gender microaggressions are a form of sexist discrimination that have detrimental effects on women’s psychological well-being. Unfortunately, these sexist occurrences are commonplace in the United States and can be experienced in a variety of ways. As such, there is a need to understand behavioral health providers’ experiences with patient-delivered gender microaggressions. In doing so, we may be able to better support women behavioral health trainees’ during their clinical development by potentially understanding the ways in which women trainees are affected by sexist patient encounters. Therefore, the present study sought to apply the Social Cognitive Model of Counselor Training and the …

Inhibitors Of Alpha-Synuclein Aggregation, Jemil Ahmed

Electronic Theses and Dissertations

Alpha-Synuclein (αS) – a neuronal, disordered, presynaptic protein – aggregates into amyloid fibrils and accumulates in the substantia nigra pars compacta of Parkinson's Disease (PD) patients. The aggregation and accumulation of αS amyloid fibrils leads to death of dopaminergic neurons; a hallmark of PD. Although it’s not clear why αS aggregates, prior studies have found that intrastriatal injection of fibril alone is sufficient to cause PD pathology in mouse and non-human primates models. These observations implicate αS as a therapeutic target against PD.

Unfortunately, there are three caveats when attempting to target αS. First, αS is a neuronal protein expressed …

The Role Of Ehd2 In Endothelial Cells, Rachael Judson

Electronic Theses and Dissertations

The role of EHD2 in terms of Cav1 interaction had not been previously characterized and was the main goal of this research. Cav1 has been shown to lead to the ubiquitination of Rac1. Because of this, the role of EHD2 in Rac1 regulation was investigated. An increase in long-term migration in endothelial cells was observed and suggested that EHD2 impacts the RhoA pathway instead of the Rac1 pathway. This lead to the hypothesis that EHD2 controls a part of the RhoA pathway. This hypothesis is supported by the loss of filamentous actin and an increase in serrated junctions in cells …

Responses Of Arthropods To Fire And How Pollinators And Pollination Services Are Affected By Fire Severity, Blyssalyn V. Bieber

Electronic Theses and Dissertations

Fires impact ecosystems globally and due to climate change, there are shifts in fire regimes that impact ecological communities which provide essential ecosystem services. Focusing on arthropods, fire can influence this ubiquitous animal group in various way. We performed a comprehensive meta-analysis evaluating how fires impact differing arthropod functional groups. We found that overall, fire negatively effects community level responses for most functional groups with herbivores as the only exception showing some positive effects of fire. We also studied mixed-severity fires that burned >20 years ago and compared floral visitor communities across fire severities. We implemented a pollinator exclusion experiment …

Characterization Of Cyclopropyl Synthases Involved In The Maturation Of Ribosomally Synthesized And Posttranslationally Modified Peptides, Yi Lien

Electronic Theses and Dissertations

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products with significant human health implications. RiPPs are synthesized from a genetically encoded precursor peptide that undergoes significant modifications by maturing enzymes, or maturases. Recently, radical-S-adenosylmethionine (rSAM) enzymes have emerged as an important family of RiPP maturases. rSAM enzymes have been shown to install ether, thioether, and carbon-carbon bonds on the precursor peptide. These modifications usually define the backbone structure of the mature RiPP. This thesis describes the characterization of a novel RiPP modification catalyzed by the radical S-adenosylmethionine enzyme TigE. TigE belongs to the TIG biosynthetic …

Exploring The Lives Of Parents Of Traditionally Marginalized Gifted Students, Lora Romero

Electronic Theses and Dissertations

The purpose of this study was to examine the lived parenting experiences of traditionally marginalized gifted students within the educational setting and at home. For this study, the researcher gathered information from seven parents of traditionally marginalized gifted students and told their stories. Since the families are traditionally marginalized the population consisted of those who have high intelligence and are a part of a historically oppressed racial/ethnic group. The study was developed using the lens of the Critical Race Theory (CRT). Through the CRT, Capper (2015), recognized that many schools analyze the function of race but lack the knowhow of …

Could Alexa Increase Your Social Worth?, Peter Tripp

Electronic Theses and Dissertations

People have historically used personal introductions to build social capital, which is the foundation of career networking and is perhaps the most effective way to advance a career (Lin, 2001). With societal changes, such as the pandemic (Venkatesh & Edirappuli, 2020), and the increasing capabilities of Artificial Intelligence (AI), new approaches may emerge that impact societal relationships. Social capital theory highlights the need for reciprocal agreements to establish the trust between parties (Gouldner, 1960). My theoretical prediction and focus of this research include two principles: The impact of reciprocity in evaluating trust of the source of the introduction and the …

An Intersectional Perspective On The Role Of Workplace Policy Among Employed Female Caregivers During The Coronavirus Pandemic, Jessica King Mclaughlin

Electronic Theses and Dissertations

Providing care for an older adult while working can be challenging, often leading to caregiver burden. The socioenvironmental context of the coronavirus pandemic creates additional complications for working caregivers. Women, who are the majority of informal caregivers, face unique stressors in the workplace (McKinsey & Company, 2019; Carnevale et al., 2018). Prior to and during the coronavirus pandemic, workplace policies have offered the potential of support, yet more information is needed on how working female informal caregivers of older adults of diverse identities receive, interpret, and experience these policies amidst the context of the pandemic. This study uses a phenomenological …

Improving Quantification Of Mitral Regurgitation Through Computational Fluid Dynamics And Ex Vivo Testing, Alexandra Flowers

Electronic Theses and Dissertations

Mitral regurgitation (MR) is a prominent cardiac disease affecting more than two million people in the United States alone. In order for patients to receive proper therapy, regurgitant volume must first be quantified. As there are an array of methods to do so, the proximal isovelocity surface area (PISA) method continues to be the most accurate and clinically used method. However, there are some difficulties obtaining the necessary measurements need for this when performing transthoracic echocardiography. This study aims to evaluate and present techniques that may be used to more accurately quantify regurgitation through ex vivo testing and computational fluid …

Perceptions Of Parental Care And Overprotection In Childhood: Influences On The Neurobiological Adaptation To Motherhood, Leah Grande

Electronic Theses and Dissertations

Recalled memories of caregiving in childhood are especially salient during the postpartum period and inform mothers’ conceptualization of her new parenting role. Positive perceptions of care received from one’s parents are related to improved maternal-infant bonding and positive parenting behaviors, whereas negative perceptions of care convey risk for maladaptive parenting. Few studies have investigated neural and biological mechanisms contributing to observed associations between childhood care and the adaptation to motherhood. The following studies address this gap by examining how perceptions of childhood parental care and overprotection are related to maternal behavior, oxytocin levels, and neural response. Methods: Perceived childhood maternal …

Assessing The Relationship Between White Privilege, White Fragility, And Masculine Gender Identity And Stressors In The Workplace, Anna Edelman

Electronic Theses and Dissertations

The current study examined how White privilege information avoidance and White fragility are related to aspects of traditional masculinity. Informed by Critical Race Theory and Critical Whiteness Studies, this study examined the link between traditional masculine norms, masculine gender identity stress, and White privilege reactions. A sample of White, working men were recruited both through snowball sampling and Amazon’s Mechanical Turk. Participants were first assessed on a variety of masculinity variables and then were randomly assigned to view one of two video vignettes. After viewing this video, their affective responses, White privilege information avoidance, and White fragility were assessed through …

Classification Of Electropherograms Using Machine Learning For Parkinson’S Disease, Soroush Dehghan

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a neurodegenerative movement disorder that progresses gradually over time. The onset of symptoms in people who are suffering from PD can vary from case to case, and it depends on the progression of the disease in each patient. The PD symptoms gradually develop and exacerbate the patient’s movements throughout time. An early diagnosis of PD could improve the outcomes of treatments and could potentially delay the progression of this disorder and that makes discovering a new diagnostic method valuable. In this study, I investigate the feasibility of using a machine learning (ML) approach to classify PD …

Inhibition Of De Novo And The Prion-Like Spread Of Amyloidogenesis Using In Vitro And In Vivo Disease Models, Johnson Anazoba Joseph

Electronic Theses and Dissertations

The aberrant fibrous, extracellular, and intracellular proteinaceous deposits in cells, organs and tissues are referred to as amyloids. These deposits are dominated by β-sheet structures that have been implicated in several neurodegenerative diseases and cancer. In this work, the types of amyloidosis studied include Parkinson’s disease (PD) using UA196 and NL5901 strains of Caenorhabditis elegans (C. elegans), Alzheimer’s disease (AD) using GMC101 strain of C. elegans, and cancer-associated mutant p53 aggregation in MIA PaCa-2 mutant cells. Several molecules including SK-129, NS132, NS163, bexarotene, a polyphenol (-)-epi-gallocatechine gallate (EGCG), ADH40, RD148, and RD242 were screened in vitro and in …

Directly Polymerizable Co Releasing Molecules, Jackson Snow

Electronic Theses and Dissertations

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make …

Lipophilic Probes For Cellular Ethylene Detection, Morgan R. Brown

Electronic Theses and Dissertations

The structure of ethylene is simple, yet its biological effects are significant. When considering its role in biology it is almost exclusively regarded as a plant hormone. Research on ethylene from plants was progressed by several advancements in analytical instrumentation, from its discovery to elucidation of its signaling pathway. There is currently limited understanding of ethylene’s role in mammals, but evidence suggests that it may be a biomarker for oxidative stress! Additional tools and technology are crucial to study this surprising and important signaling role in mammals. Our group has developed molecular ethylene probes as a strategy to detect ethylene …

Music Theory Pedagogy For The Violin: Cognitive Philosophy And Three Model Curricula, Morganne J. Mcintyre

Electronic Theses and Dissertations

Violin playing promotes a connection between mind and body that allows the performer to internalize, or embody, tactile features of the instrument, such as the distance between strings, the feeling of the fingertips on the fingerboard, the interval size between notes, and many other aspects. This thesis designs a pedagogy that employs the violin’s physical attributes to provide the beginning through advanced player with a deeper understanding of music theory. The thesis suggests pairing of physical learning and musical theory at each stage of a violinist’s musical education. Chapter 1 surveys embodied cognition and cognitive artifacts. Chapter 2 applies these …

Puerto Ricans And Asthma: Looking Through The Lens Of Historical Trauma, Lisa Colón

Electronic Theses and Dissertations

This study utilized an explorative phenomenological qualitative design to begin understanding the many ways Puerto Ricans experience asthma. Further is sought to understand the asthma experience broadly and within the context of the hurricanes that devastated Puerto Rico in 2017 including the governments’ responses to that devastation. Another core goal of this study was the conceptual and empirical application of the theoretical framework of historical trauma to Puerto Ricans. I conducted 12 semi structured interviews with collaborators who expressed a range of asthma experiences. My collaborators represented a mixture of those who lived through the hurricanes in Puerto Rico and …

Where Virtual Well-Being Becomes Reality, Colleen M. Reilly

Electronic Theses and Dissertations

Strategies to mitigate the spread of COVID-19, specifically quarantine and social distancing protocols, have exposed a troubling paradox: mandated isolation meant to save lives has inadvertently contributed to a decline in America’s well-being. Prolonged isolation due to more remote work and decentralized workplaces has been associated with widespread loneliness and diminished physical and mental health, with effects compounded by limited face-to-face access to social support systems. While remote communication technologies (e.g., video chat) can connect individuals with colleagues and social networks, remote technologies might have limited effectiveness in business and social contexts. This study uses Roger’s Diffusion of Innovation Theory …

Emotion Dysregulation And Intimate Partner Aggression During Pregnancy: Leveraging Both Partners’ Experiences With Dyadic Data, Victoria M. Atzl

Electronic Theses and Dissertations

Intimate partner aggression (IPA) during pregnancy is a significant public health problem that has negative consequences for maternal and fetal health. This study examined emotion dysregulation as a potential predictor of IPA during pregnancy from a dyadic perspective. Participants were 113 couples expecting a baby and included 113 mothers (MOBs; Mage = 27.50 years, SDage = 5.53, rangeage = 19-40; 38.1% White, 24.8% Latinx, 15.9% African American, 14.2% biracial/multiracial, 3.5% Asian American/Pacific Islander, 2.7% Native American and .8% other) and 113 fathers (FOBs; Mage = 29.83 years, SDage = 7.61, rangeage = 18-55; 38.1% White, 22.1% African American, 20.4% Latinx, …

Mis-Specification Of Functional Forms In Growth Mixture Modeling: A Monte Carlo Simulation, Richa Ghevarghese

Electronic Theses and Dissertations

Growth mixture modeling (GMM) is a methodological tool used to represent heterogeneity in longitudinal datasets through the identification of unobserved subgroups following qualitatively and quantitatively distinct trajectories in a population. These growth trajectories or functional forms are informed by the underlying developmental theory, are distinct to each subgroup, and form the core assumptions of the model. Therefore, the accuracy of the assumed functional forms of growth strongly influences substantive research and theories of growth. While there is evidence of mis-specified functional forms of growth in GMM literature, the weight of this violation has been largely overlooked. Current solutions to circumvent …

Measurements Of Atmospheric Radicals, Heather L. Runberg

Electronic Theses and Dissertations

Atmospheric particulate matter (PM) is a global health concern. PM_2.5 is formed primarily through combustion processes such as automobile use and industrial activity. Natural sources of PM_2.5 result from events like volcanos and wildfires. Upon inhalation, PM_2.5 is small enough to travel deep into the lungs where it can form reactive oxygen species (ROS), such as hydroxyl radical (OH), causing oxidative damage to pulmonary tissues. PM_2.5 has been linked to cardiopulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), and high blood pressure.

PM_2.5 is small enough to remain aloft and travel many hundreds …

Esipt-Enabled Alkyne Migration Provides Rapid Access To Benzoxazinones, Andrés G. Muñoz

Electronic Theses and Dissertations

Benozoxazinones have long been of interest to agrochemical scientists and medicinal chemists because of their widespread biological activity. These scaffolds are also of interest to synthetic chemists, who recognize the utility of benzoxazinones for accessing functionalized heterocycles. The use of efavirenz, a benzoxazinone-based reverse transcriptase inhibitor used in the treatment of HIV-1, has brought increased attention to this privileged pharmacophore. While there exist numerous strategies for synthesizing benzoxazinones, methods that do not require the use of acutely toxic and environmentally hazardous reagents are lacking. Consequently, there is a need to develop new methods for constructing this valuable scaffold. Herein, we …

The Intersection Of Traumatic Brain Injury And Homelessness, Stephanie A. Chassman

Electronic Theses and Dissertations

The rates of TBI are significantly higher among individuals experiencing homelessness compared to the general population. Up to half of individuals experiencing homelessness may have a TBI. Accurate prevalence rates of TBI among individuals experiencing homelessness are difficult to obtain due to different methods of sampling participants and differing definitions of TBI; therefore, estimates may be underrepresented. Despite past research that has examined the relationship between TBI and homelessness, there are specific gaps in knowledge such as correlates and risk factors of TBI among individuals experiencing homelessness. This three-manuscript dissertation attempts to address these gaps in knowledge.

The first manuscript …

Developing, Refining, And Testing The Intersectional Model Of Service Use: A Transgender And Nonbinary-Specific Model Of Healthcare Access, Jarrod Call

Electronic Theses and Dissertations

Transgender and nonbinary (TNB) people are more likely to experience negative health outcomes than cisgender (i.e., not TNB) people, but less likely to access healthcare services due to the systemic forces of transphobia and cisgenderism. Despite this, there are few theoretical models of healthcare access specifically designed for TNB people. This three-paper dissertation addresses this gap by developing, refining, and testing the Intersectional Model of Service Use (IMSU), a population-specific framework for researching TNB healthcare access. Manuscript one describes how the initial IMSU was developed from an integrative review of currently available TNB healthcare access literature. This initial IMSU was …

Extracellular Vesicles And Lipid Flippase Regulators In C. Elegans, Lauren Pitts

Electronic Theses and Dissertations

Extracellular vesicles (EVs) are membrane derived organelles released by all cell types and carry a vast array of cargos that can influence communication, development, and disease. One type of EV, known as microvesicles, form by budding directly from the plasma membrane in a process known as ectocytosis, however the mechanisms that govern this process are poorly understood. In C. elegans, the P4-ATPase, TAT-5, along with its activator, PAD-1, inhibit EV release from the plasma membrane by inhibiting phosphatidylethanolamine (PE) exposure on the outer leaflet of the plasma membrane. We identified 3 key domains of PAD-1 that are required to inhibit …

Structural And Hemodynamic Analysis Of Transcatheter Aortic Valves, Dong Qiu

Electronic Theses and Dissertations

The transcatheter aortic valve replacement (TAVR) procedure has become a well-established procedure for high, intermediate-risk, and low-risk patients. However, there is limited clinical data on the TAV's long-term durability, unlike SAV devices. Computational simulations can be an alternative way to evaluate the TAV devices. This dissertation aims to conduct structural and hemodynamic analyses on the TAV devices under different conditions using computational simulation approaches.

Initially, the impact of the bicuspid aortic valve on the TAV devices was evaluated. The result indicated that the CoreValve-like supra-annular self-expandable device was likely to have increased stress and strain on the leaflet when it …