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Simulation Of A Ship And Tension Leg Platform Wind Turbine Collision, Jiamin Guo, Yu Zhao, Weigang Chen, Guangeng Zhou Jan 2022

Simulation Of A Ship And Tension Leg Platform Wind Turbine Collision, Jiamin Guo, Yu Zhao, Weigang Chen, Guangeng Zhou

Journal of Marine Science and Technology–Taiwan

Collisions between ships and tension leg platform wind turbines (TLPWTs) result in the TLPWT damage, including tower damage and tension leg breakage. This paper details a collision between a ship and TLPWT simulated using the LS-DYNA software package. During simulation, the behaviors of the water around the ship and of the TLPWT were processed using the constant added mass and the fluid–structure interaction methods, respectively. The results indicate that the energy conversion during collision is generally consistent with the law of conversion of energy, suggesting that the simulation’s calculations are acceptable. The TLPWT simulation results imply that two distinct collisions …


The Influences Of Promising Feedstock Variability On Advanced Biofuel Production: A Review, Cherng-Yuan Lin Jan 2022

The Influences Of Promising Feedstock Variability On Advanced Biofuel Production: A Review, Cherng-Yuan Lin

Journal of Marine Science and Technology–Taiwan

The contribution of biofuels is expected to continuously increase in the global fuel market, as they are environmentally-friendly and provide renewable energy. Four generations of biofuels are categorized and are primarily based on their feedstock sources and the production technologies that are used. The influence of promising feedstock types and the availability on the production technologies and the fuel properties of advanced-generation biofuels are not systematically examined in the literature. Hence, this research extensively reviews the potential impact of feedstock sources and their variability on the production and characteristics of biofuels. The approaches of theoretical analysis and inference referred to …


Why Narrative Poetry Still Matters In Stylistics, Rachid Acim Jan 2022

Why Narrative Poetry Still Matters In Stylistics, Rachid Acim

Journal of Educational Research and Practice

In Morocco, debates over English language instruction have marginalized poetry as a distinct literary genre. The shortage of poetry events arguably makes poetry teaching both daunting and intimidating. Besides fostering trust, memorization, and empathy, helping students develop a penchant for English language, as well as humanity, poetry, and narrative poetry, in particular, proffers teachers ample opportunities to fully engage students in the learning process. Not only does it awaken their senses and make them establish connections but leads them to think in a critical way about the world around them. In this paper, the teaching of narrative poetry through the …


The Effect Of Instructor-To-Student Ratios, Academic Preparation, And Selective Admissions On Retention Rates Among Caahep Accredited Paramedic Training Programs., Justin G. Tilghman Jan 2022

The Effect Of Instructor-To-Student Ratios, Academic Preparation, And Selective Admissions On Retention Rates Among Caahep Accredited Paramedic Training Programs., Justin G. Tilghman

Internet Journal of Allied Health Sciences and Practice

Purpose: This study was a non-experimental evaluative study designed to identify the effects of instructor-to-student ratios, academic preparation, and selective admissions processes on retention rates among CAAHEP accredited paramedic training programs in the United States. Methods: Self-reported data from accredited program directors was analyzed to identify what relationships, if any, existed among the variables. Results: Results showed no effect of instructor-to-student ratios or academic preparation on retention rates. However, those programs that utilized selective admissions processes reported a statistically significantly higher student retention rate when compared to those that did not. Conclusions: Paramedic programs seeking to improve retention rates …


Animal Assisted Therapy For Older Adults In Aged Care Facilities: A Rapid Review, Mitchell A. Franklin, Tracey Parnell, Natasha Versi, Rodney Pope Jan 2022

Animal Assisted Therapy For Older Adults In Aged Care Facilities: A Rapid Review, Mitchell A. Franklin, Tracey Parnell, Natasha Versi, Rodney Pope

Internet Journal of Allied Health Sciences and Practice

Purpose: Research has demonstrated the effectiveness of animal assisted therapy (AAT) for improving the mental health of older adults in residential care. The aim of this rapid review was to synthesise existing research evidence to determine the approaches that AAT should take to enhance outcomes for older adults living in residential care. Methods: A systematic literature search was conducted to identify studies published between 2009 and 2019 that investigated AAT and improvement in physical and/or psychosocial outcomes for adults aged over 65 years, living in residential care. Studies were critically appraised to determine methodological quality, key data were extracted, and …


Language Discordance And Telephone Interpretation Complicates Pain Neuroscience Education In Physical Therapy Management Of A Patient With Acute Low Back Pain, Margaret C. Burns, Tamara S. Struessel Jan 2022

Language Discordance And Telephone Interpretation Complicates Pain Neuroscience Education In Physical Therapy Management Of A Patient With Acute Low Back Pain, Margaret C. Burns, Tamara S. Struessel

Internet Journal of Allied Health Sciences and Practice

Purpose: Pain neuroscience education (PNE) is an intervention used for musculoskeletal pain to improve understanding of pain processes; PNE can decrease pain levels, improve function, and lower disability. Clear communication between the patient and provider is important for PNE to be an effective intervention. There is a lack of research on how a language discordance may impact that communication, and therefore the effectiveness of PNE. Purposes: 1) describe the physical therapist management of a Spanish speaking patient with acute low back pain (LBP) while using an off-site telephone interpreting service and 2) examine how PNE treatment was impacted by a …


Attitudes And Usage Of Face Masks During The Covid-19 Pandemic Among Occupational Therapy Professionals In Texas, Stephen A. Cage, Diane P. Brown, Brandon J. Warner, Diana M. Gallegos, Heidi M. Cage Jan 2022

Attitudes And Usage Of Face Masks During The Covid-19 Pandemic Among Occupational Therapy Professionals In Texas, Stephen A. Cage, Diane P. Brown, Brandon J. Warner, Diana M. Gallegos, Heidi M. Cage

Internet Journal of Allied Health Sciences and Practice

Purpose: Following the widespread transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), multiple business and schools drastically reduced face-to-face services. Additionally, many state and local governments enacted face mask mandates and other legislations aimed at decreasing the spread of the virus. Current research is being conducted to evaluate the epidemiology, recognition, treatment, and prevention of coronavirus disease 2019 (COVID-19), the disease associated with SARS-CoV-2. At the time of this study, there is no published research on the attitudes and usage of face masks or face coverings among certified occupational therapy professionals during the COVID-19 Pandemic. The purpose of this …


A Chance-Constrained Linear Model For Beef Policy Analysis, Claudio F. Machado, S. T. Morris, C. Dake, A. Macdonald, I. M. Brookes, F. Di Croce, F. Gonzalez, N. J. Auza Jan 2022

A Chance-Constrained Linear Model For Beef Policy Analysis, Claudio F. Machado, S. T. Morris, C. Dake, A. Macdonald, I. M. Brookes, F. Di Croce, F. Gonzalez, N. J. Auza

IGC Proceedings (1977-2023)

A simple linear model to evaluate different bull beef policies (BBP) by incorporating the stochastic nature of pasture yield from a database with separate chance constraints (ChC) was developed. A 100 ha farm was used, and the model was run with five different BBP and set to different levels of pasture yield risk to maximise production.ha-1.year-1. Summer was the most risky season, and the optimum mix of policies changed at different levels of risk. Chance constraint represents an interesting and simple alternative to include pasture variation into a linear model.


Mapping Nitrogen Fixing Shrubs In Dry Unimproved Tussock Grassland, C. C. Boswell, W. L. Lowther, P. D. Espie Jan 2022

Mapping Nitrogen Fixing Shrubs In Dry Unimproved Tussock Grassland, C. C. Boswell, W. L. Lowther, P. D. Espie

IGC Proceedings (1977-2023)

Global Positioning System (GPS) was used to both map the positions of individual nitrogen-fixing shrub plants and record individual plant height and breadth dimensions, within a small catchment of dry sub-humid unimproved short tussock grassland. The distributions of different species of shrubs varied with different landscape units within the catchment. The information will provide the base data for a first approximation of the role of the shrubs in the nitrogen balance of the ecosystem, which is pivotal to the sustainability of pastoral farming in the tussock grasslands.


Repeated Measurement Analyses Of Forages In Cropping Systems, A. R. De Freitas, O. Primavesi, L. De A. Corrêa, A. C. Primavesi, E. B. Pott, A. Dos S. Mascioli Jan 2022

Repeated Measurement Analyses Of Forages In Cropping Systems, A. R. De Freitas, O. Primavesi, L. De A. Corrêa, A. C. Primavesi, E. B. Pott, A. Dos S. Mascioli

IGC Proceedings (1977-2023)

Repeated measurements (RM) are common in forage experiments. The data used in this study were accumulated ammonia losses by volatilization (N) and dry matter production (DM) of Cynodon dactylon cv. Coastcross pasture from an experiment in blocks with five levels of urea: 0, 25, 50, 100 and 200 kg of N ha-1, applied in five periods (cuttings). For N, RM were the averages of cuttings and nine days of observation. The F test for the hypothesis of no effect for Period and Level x Period interaction (DM) and for Days and Level x Days interaction was not affected …


Farmwi$E: A Flexible Decision Support Tool For Grazing Systems Management, A. D. Moore Jan 2022

Farmwi$E: A Flexible Decision Support Tool For Grazing Systems Management, A. D. Moore

IGC Proceedings (1977-2023)

CSIRO's new FarmWi$e decision support tool provides a framework that permits pasture-livestock systems and management policies of any level of complexity to be simulated. An underlying "modelling protocol" permits other simulation models to be added, further extending its domain of applicability. Management policies are specified in FarmWi$e by means of rules that govern when, whether and how management events take place. An example of the use of FarmWi$e to study lamb production is given.


Sward Height; Visual Estimate Compared With Plate Meter Height, W. B. Bryan, E. C. Prigge, E. L. Nestor, O. J. Gekara, M. A. Schettini Jan 2022

Sward Height; Visual Estimate Compared With Plate Meter Height, W. B. Bryan, E. C. Prigge, E. L. Nestor, O. J. Gekara, M. A. Schettini

IGC Proceedings (1977-2023)

Sward height (SH) is widely used in pasture research and farm practice to evaluate pasture conditions. Visual estimates can take less time than actual measurements. This study compared visually estimated SH, of continuously grazed cool-season permanent pasture with plate meter height. Weekly estimates, by five people, were made on 12, 0.75 to 1 ha fields, grazed at two intensities. Paired data (visual estimate and plate meter height) were subjected to variance and covariance analyses and prediction equations were developed. Average visual height accounted for 86% of the variability in plate meter height. Inclusion of other sources of variability in the …


Application Of Synthetic Peptide Cep1 Increases Nutrient Uptake Rates Along Plant Roots, Sonali Roy, Marcus Griffiths, Ivone Torres-Jerez, Bailey Sanchez, Elizabeth Antonelli, Divya Jain, Nicholas Krom, Shulan Zhang, Larry M. York, Wolf-Rüdiger Scheible, Michael Udvardi Jan 2022

Application Of Synthetic Peptide Cep1 Increases Nutrient Uptake Rates Along Plant Roots, Sonali Roy, Marcus Griffiths, Ivone Torres-Jerez, Bailey Sanchez, Elizabeth Antonelli, Divya Jain, Nicholas Krom, Shulan Zhang, Larry M. York, Wolf-Rüdiger Scheible, Michael Udvardi

Agricultural and Environmental Sciences Faculty Research

The root system of a plant provides vital functions including resource uptake, storage, and anchorage in soil. The uptake of macro-nutrients like nitrogen (N), phosphorus (P), potassium (K), and sulphur (S) from the soil is critical for plant growth and development. Small signaling peptide (SSP) hormones are best known as potent regulators of plant growth and development with a few also known to have specialized roles in macronutrient utilization. Here we describe a high throughput phenotyping platform for testing SSP effects on root uptake of multiple nutrients. The SSP, CEP1 (C-TERMINALLY ENCODED PEPTIDE) enhanced nitrate uptake rate per unit root …


Firearms And Toolmark Error Rates, Susan Vanderplas, Kori Khan, Heike Hofmann, Alicia L. Carriquiry Jan 2022

Firearms And Toolmark Error Rates, Susan Vanderplas, Kori Khan, Heike Hofmann, Alicia L. Carriquiry

Department of Statistics: Faculty Publications

We have outlined several problems with the state of error rate studies on firearm and toolmark examination. Fundamentally, we do not know what the error rate is for these types of comparisons. This is a failure of the scientific study of toolmarks, rather than the examiners themselves, but until this is corrected with multiple studies that meet the criteria described in Section 3, we cannot support the use of this evidence in criminal proceedings.


Open Problems In Extracellular Rna Data Analysis: Insights From An Ercc Online Workshop., Roger P Alexander, Robert R Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E A Max, Joel Rozowsky, Karolina Elżbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, Bojan Losic, Eric L Van Nostrand, Emily Laplante, Bogdan Mateescu, Brian S White, Rongshan Yu, Aleksander Milosavljevic, Gustavo Stolovitzky, Ryan M Spengler Jan 2022

Open Problems In Extracellular Rna Data Analysis: Insights From An Ercc Online Workshop., Roger P Alexander, Robert R Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E A Max, Joel Rozowsky, Karolina Elżbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, Bojan Losic, Eric L Van Nostrand, Emily Laplante, Bogdan Mateescu, Brian S White, Rongshan Yu, Aleksander Milosavljevic, Gustavo Stolovitzky, Ryan M Spengler

Faculty Research 2022

We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a role in intercellular signaling, serve as biomarkers of disease, and form the basis of new strategies for disease treatment. The Extracellular RNA Communication Consortium (ERCC) hosted a two-day online workshop (April 19-20, 2021) on the unique challenges of exRNA data analysis. The goal was to foster an open dialog about best practices and discuss open problems in the field, focusing initially on small exRNA sequencing data. Video recordings of workshop …


Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative Jan 2022

Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative

Publications and Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. It is one of the leading sources of morbidity and mortality in the aging population AD cardinal symptoms include memory and executive function impairment that profoundly alters a patient’s ability to perform activities of daily living. People with mild cognitive impairment (MCI) exhibit many of the early clinical symptoms of patients with AD and have a high chance of converting to AD in their lifetime. Diagnostic criteria rely on clinical assessment and brain magnetic resonance imaging (MRI). Many groups are working to help automate this process to improve the clinical workflow. Current …


Can Lethal Autonomous Weapons Be Just?, Noreen L. Herzfeld, Robert H. Latiff Jan 2022

Can Lethal Autonomous Weapons Be Just?, Noreen L. Herzfeld, Robert H. Latiff

Computer Science Faculty Publications

In 2018 the United States Department of Defense (DoD) created a new Joint Artificial Intelligence Center to study the adoption of AI by the military. Their strategy, outlined in a document entitled, “Harnessing AI to Advance Our Security and Prosperity,” proposes to accelerate the adoption of AI in the military by fostering a culture of experimentation and calculated risk taking, noting that AI will change the character of the future battlefield and, even more, the pace of battle. Is there any way to ensure that this future battlefield will be just? Can the age-old precepts of just warfare help guide …


Jefferson Digital Commons Quarterly Report: October-December 2021, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma Jan 2022

Jefferson Digital Commons Quarterly Report: October-December 2021, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

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Investigation Of Metastable Low Dimensional Halometallates, Navindra Keerthisinghe, Matthew S. Christian, Anna A. Berseneva, Gregory Morrison, Vladislav V. Klepov, Mark D. Smith, Hans Conrad Zur Loye Jan 2022

Investigation Of Metastable Low Dimensional Halometallates, Navindra Keerthisinghe, Matthew S. Christian, Anna A. Berseneva, Gregory Morrison, Vladislav V. Klepov, Mark D. Smith, Hans Conrad Zur Loye

Faculty Publications

The solvothermal synthesis, structure determination and optical characterization of five new metastable halometallate compounds, [1,10-phenH][Pb3.5I8] (1), [1,10-phenH2][Pb5I12]·(H2O) (2), [1,10-phen][Pb2I4] (3), [1,10-phen]2[Pb5Br10] (4) and [1,10-phenH][SbI4]·(H2O) (5), are reported. The materials exhibit rich structural diversity and exhibit structural dimensionalities that include 1D chains, 2D sheets and 3D frameworks. The optical spectra of these materials are consistent with bandgaps ranging from 2.70 to 3.44 eV. We show …


The Frequency Of Periodontitis In End-Stage Renal Disease On Hemodialysis In A Sample Of Egyptian Population: Multi-Center Clinical Cross-Sectional Study, Asmaa Ras, Enji A. Ahmed, Radwa Hussein, Eman Khalil Jan 2022

The Frequency Of Periodontitis In End-Stage Renal Disease On Hemodialysis In A Sample Of Egyptian Population: Multi-Center Clinical Cross-Sectional Study, Asmaa Ras, Enji A. Ahmed, Radwa Hussein, Eman Khalil

Dentistry

Abstract Background: There is a general assumption that periodontal disease is highly prevalent among patients with chronic renal failure undergoing hemodialysis. The aim of the study to estimate the frequency of periodontitis in patients on hemodialysis among a sample of the Egyptian population, as well as the correlation between different clinical parameters of periodontal status with serum creatinine and blood urea. This may rule out the bidirectional relation‑ ship between periodontitis and renal failure in patients on hemodialysis. Methods: The study was conducted on 263 hemodialysis patients (165 males and 98 females) at three dialysis cent‑ ers in Benha Governorate, …


Assessing Reproducibility Of Inherited Variants Detected With Short-Read Whole Genome Sequencing, Bohu Pan, Luyao Ren, Vitor Onuchic, Meijian Guan, Rebecca Kusko, Steve Bruinsma, Len Trigg, Andreas Scherer, Baitang Ning, Chaoyang Zhang, Christine Glidewell-Kenney, Chunlin Xiao, Eric Donaldson, Fritz J. Sedlazeck, Gary Schroth, Gokhan Yavas, Haiying Grunenwald, Haodong Chen, Heather Meinholz, Joe Meehan, Jing Wang, Jingcheng Yang, Jonathan Foox, Jun Shang, Kelci Miclaus, Lianhua Dong, Leming Shi, Marghoob Mohiyuddin, Mehdi Pirooznia, Ping Gong, Rooz Golshani, Russ Wolfinger, Samir Lababidi, Sayed Mohammed Ebrahim Sahraeian, Steve Sherry, Tao Han, Tieliu Shi, Wanwan Hou, Weigong Ge, Wen Zou, Wenjing Guo, Wenjun Bao, Wenzhong Xiao, Xiaohui Fan, Yoichi Gondo, Ying Yu, Yongmei Zhao, Zhenqiang Su, Zhichao Liu, Weida Tong, Wenming Xiao, Justin M. Zook, Yuanting Zeng, Huixiao Hong Jan 2022

Assessing Reproducibility Of Inherited Variants Detected With Short-Read Whole Genome Sequencing, Bohu Pan, Luyao Ren, Vitor Onuchic, Meijian Guan, Rebecca Kusko, Steve Bruinsma, Len Trigg, Andreas Scherer, Baitang Ning, Chaoyang Zhang, Christine Glidewell-Kenney, Chunlin Xiao, Eric Donaldson, Fritz J. Sedlazeck, Gary Schroth, Gokhan Yavas, Haiying Grunenwald, Haodong Chen, Heather Meinholz, Joe Meehan, Jing Wang, Jingcheng Yang, Jonathan Foox, Jun Shang, Kelci Miclaus, Lianhua Dong, Leming Shi, Marghoob Mohiyuddin, Mehdi Pirooznia, Ping Gong, Rooz Golshani, Russ Wolfinger, Samir Lababidi, Sayed Mohammed Ebrahim Sahraeian, Steve Sherry, Tao Han, Tieliu Shi, Wanwan Hou, Weigong Ge, Wen Zou, Wenjing Guo, Wenjun Bao, Wenzhong Xiao, Xiaohui Fan, Yoichi Gondo, Ying Yu, Yongmei Zhao, Zhenqiang Su, Zhichao Liu, Weida Tong, Wenming Xiao, Justin M. Zook, Yuanting Zeng, Huixiao Hong

Faculty Publications

Background: Reproducible detection of inherited variants with whole genome sequencing (WGS) is vital for the implementation of precision medicine and is a complicated process in which each step affects variant call quality. Systematically assessing reproducibility of inherited variants with WGS and impact of each step in the process is needed for understanding and improving quality of inherited variants from WGS.

Results: To dissect the impact of factors involved in detection of inherited variants with WGS, we sequence triplicates of eight DNA samples representing two populations on three short-read sequencing platforms using three library kits in six labs and …


The Guardian, Week Of January 3, 2022, Wright State Student Body Jan 2022

The Guardian, Week Of January 3, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of January 3, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.


The Rice Theory Of Culture, Thomas Talhelm Jan 2022

The Rice Theory Of Culture, Thomas Talhelm

Online Readings in Psychology and Culture

The rice theory of culture is the idea that rice farming societies developed into more interdependent, tight cultures in response to the demands of the plant. Farming in general is an interdependent subsistence style, but traditional paddy rice farming was starkly different from other major crops like wheat, corn, and potatoes. Paddy rice required twice as much labor per hectare as wheat farming. Farmers responded by creating customs to share labor. Paddy rice also depended on irrigation systems to flood and drain the fields. Once farmers controlled water, they now had to coordinate how much water each farmer got, when …


Centrifugal Assembly Of Bijel Ropes Via Helical Microfluidics, Shankar P. Kharal Jan 2022

Centrifugal Assembly Of Bijel Ropes Via Helical Microfluidics, Shankar P. Kharal

Theses and Dissertations

Bicontinuous interfacially jammed emulsion gels (bijels) are soft materials that retain a liquid bicontinuous network stabilized by an interfacially jammed layer of nanoparticles. In this thesis, we investigated a microfluidic twisting method to fabricate micro-ropes of nano-structured bijel fibers. This method shows how weak microfibers with tensile strengths of a few kPa can be reinforced by 4 orders of magnitude by means of microfluidic twisting. Microfluidic twisting allows to produce continuous bijel fiber ropes of controllable architecture. Modelling the fluid flow field reveals the rope geometry dependence on a subtle force balance composed of rotational and translational shear stresses. However, …


Clinical Performance Of The Xpert® Ct/Ng Test For Detection Of Chlamydia Trachomatis And Neisseria Gonorrhoeae: A Multicenter Evaluation In Chinese Urban Hospitals, Fred C. Tenover, Yan Han, Mei-Qin Shi, Qing-Ping Jiang, Wen-Jing Le, Xiao-Lin Qin, Han-Zhen Xiong, He-Ping Zheng, Yi-Wei Tang, Yue-Ping Yin Jan 2022

Clinical Performance Of The Xpert® Ct/Ng Test For Detection Of Chlamydia Trachomatis And Neisseria Gonorrhoeae: A Multicenter Evaluation In Chinese Urban Hospitals, Fred C. Tenover, Yan Han, Mei-Qin Shi, Qing-Ping Jiang, Wen-Jing Le, Xiao-Lin Qin, Han-Zhen Xiong, He-Ping Zheng, Yi-Wei Tang, Yue-Ping Yin

Biology Faculty Publications

Background: We aimed to evaluate the clinical performance of the GeneXpert® (Xpert) CT/NG assay for the detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) using urine and cervical swabs collected from patients in China.

Methods: This study was conducted from September 2016 to September 2018 in three Chinese urban hospitals. The results from the Xpert CT/NG test were compared to those from the Roche cobas® 4800 CT/NG test. Discordant results were confirmed by DNA sequence analysis.

Results: In this study, 619 first void urine (FVU) specimens and 1,042 cervical swab specimens were included in the final dataset. There were …


Care Gaps And Recommendations In Vestibular Migraine: An Expert Panel Summit, Monica P Mallampalli, Habib G Rizk, Amir Kheradmand, Shin C Beh, Mehdi Abouzari, Alaina M Bassett, James Buskirk, Claire E J Ceriani, Matthew G Crowson, Hamid Djalilian, Joel A Goebel, Jeffery J Kuhn, Anne E Luebke, Marco Mandalà, Magdalena Nowaczewska, Nicole Spare, Roberto Teggi, Maurizio Versino, Hsiangkuo Yuan, Ashley Zaleski-King, Michael Teixido, Frederick Godley Jan 2022

Care Gaps And Recommendations In Vestibular Migraine: An Expert Panel Summit, Monica P Mallampalli, Habib G Rizk, Amir Kheradmand, Shin C Beh, Mehdi Abouzari, Alaina M Bassett, James Buskirk, Claire E J Ceriani, Matthew G Crowson, Hamid Djalilian, Joel A Goebel, Jeffery J Kuhn, Anne E Luebke, Marco Mandalà, Magdalena Nowaczewska, Nicole Spare, Roberto Teggi, Maurizio Versino, Hsiangkuo Yuan, Ashley Zaleski-King, Michael Teixido, Frederick Godley

Department of Neurology Faculty Papers

Vestibular migraine (VM) is an increasingly recognized pathology yet remains as an underdiagnosed cause of vestibular disorders. While current diagnostic criteria are codified in the 2012 Barany Society document and included in the third edition of the international classification of headache disorders, the pathophysiology of this disorder is still elusive. The Association for Migraine Disorders hosted a multidisciplinary, international expert workshop in October 2020 and identified seven current care gaps that the scientific community needs to resolve, including a better understanding of the range of symptoms and phenotypes of VM, the lack of a diagnostic marker, a better understanding of …


Enhancing Precision In Bioprinting Utilizing Fuzzy Systems, Ashkan Sedigh, Dayna Dipiero, Kristy M. Shine, Ryan E. Tomlinson Jan 2022

Enhancing Precision In Bioprinting Utilizing Fuzzy Systems, Ashkan Sedigh, Dayna Dipiero, Kristy M. Shine, Ryan E. Tomlinson

Department of Orthopaedic Surgery Faculty Papers

Bioprinting facilitates the generation of complex, three-dimensional (3D), cell-based constructs for a variety of applications. Although multiple bioprinting technologies have been developed, extrusion-based systems have become the dominant technology due to the diversity of substrate materials (i.e. bioinks) that can be accommodated, either individually or in combination. Each bioink has unique material properties and extrusion characteristics that limit bioprinting precision, particularly when generating identically shaped constructs from different bioinks. Here, we aimed to achieve high precision (i.e. repeatability) across samples by generating bioink-specific printing parameters using a systematic approach. We hypothesized that a Fuzzy system could be used as a …


Opa1 Modulates Mitochondrial Ca 2+ Uptake Through Er-Mitochondria Coupling, Benjamín Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, María E Andrés, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner Jan 2022

Opa1 Modulates Mitochondrial Ca 2+ Uptake Through Er-Mitochondria Coupling, Benjamín Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, María E Andrés, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae organization, which are central to oxidative metabolism. Mitochondrial dynamics and IMM organization have also been implicated in Ca2+ homeostasis and signaling but the specific involvements of OPA1 in Ca2+ dynamics remain to be established. Here we studied the possible outcomes of OPA1 and its ADOA-linked mutations in Ca2+ homeostasis using rescue and overexpression strategies in Opa1-deficient and wild-type murine embryonic fibroblasts (MEFs), respectively and in …


Postseptic Cognitive Impairment And Expression Of Apoe In Peripheral Blood: The Cognition After Sepsis (Cass) Observational Pilot Study, Samuel M. Brown, Sarah J. Beesley, Chris Stubben, Emily L. Wilson, Angela P. Presson, Colin Grissom, Colin Maguire, Matthew T. Rondina, Ramona O. Hopkins Jan 2022

Postseptic Cognitive Impairment And Expression Of Apoe In Peripheral Blood: The Cognition After Sepsis (Cass) Observational Pilot Study, Samuel M. Brown, Sarah J. Beesley, Chris Stubben, Emily L. Wilson, Angela P. Presson, Colin Grissom, Colin Maguire, Matthew T. Rondina, Ramona O. Hopkins

Faculty Publications

Background: Cognitive impairment after sepsis is an important clinical problem. Determinants of postseptic cognitive impairment are not well understood. We thus undertook a systems biology approach to exploring a possible role for apolipoprotein E (APOE) in postseptic cognitive impairment.

Design: Prospective, observational cohort. Setting: Intermountain Medical Center, a tertiary referral center in Utah.

Patients/Participants: Patients with sepsis admitted to study intensive care units. Interventions: None.

Methods: We obtained peripheral blood for deep sequencing of RNA and followed up survivors at 6 months with a battery of cognitive instruments. We defined cognitive impairment based on the 6-month Hayling test of executive …


Cardiac Startle Response And Clinical Outcomes In Preschool Children With Fragile X Syndrome And Autism Spectrum Disorder, Jordan Ezell, Abigail L. Hogan Phd, Elizabeth A. Will Ph.D., Bcba, Kayla Smith, Jane E. Roberts Jan 2022

Cardiac Startle Response And Clinical Outcomes In Preschool Children With Fragile X Syndrome And Autism Spectrum Disorder, Jordan Ezell, Abigail L. Hogan Phd, Elizabeth A. Will Ph.D., Bcba, Kayla Smith, Jane E. Roberts

Faculty Publications

Objective: Poor physiological regulation in response to threat is linked to multiple negative developmental outcomes including anxiety, which is highly prevalent and impairing in young children with neurodevelopmental disabilities like fragile X syndrome (FXS) and autism spectrum disorder (ASD). The present study contrasted cardiac startle response in pre-school-aged children with FXS, with and without ASD, to children with non-syndromic ASD (nsASD) and neurotypical controls (NT). The relationship of cardiac startle to non-verbal mental age (NVMA), ASD severity, and parent-reported anxiety was also examined.

Method: Four age-matched groups of pre-school children participated including those with FXS without ASD (FXS-Only, n = …