Digital Commons Network^™

January 5, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Comparison Of Percutaneous Vs Oral Infection Of Hamsters With The Hookworm Ancylostoma Ceylanicum: Parasite Development, Pathology And Primary Immune Response, Richard D. Bungiro, Lisa M. Harrison, Blaise Dondji, Michael Cappello

Biology Faculty Scholarship

Background

Hundreds of millions of people in poor countries continue to suffer from disease caused by bloodfeeding hookworms. While mice and rats are not reliably permissive hosts for any human hookworm species, adult Golden Syrian hamsters are fully permissive for the human and animal pathogen Ancylostoma ceylanicum. Similar to humans, hamsters may be infected with A. ceylanicum third-stage larvae orally or percutaneously. Oral infection typically leads to consistent worm yields in hamsters but may not accurately reflect the clinical and immunological manifestations of human infection resulting from skin penetration.

Methodology/Principal findings

In this study we compared host responses …

I Just Work Here, Carrie Rudd

Theses and Dissertations

Via an in-depth analysis of the artist’s works and the material, social, and historical possibilities of Painting, the following paper investigates the myriad approaches for Painting to communicate complex ideas both physically and psychologically.

A Liquid Line, Sofía Del Mar Collins

Theses and Dissertations

My practice searches for fertility amidst cultural and material detritus. This paper outlines flows embedded in becomingness. My thesis exhibition included Liquidscapes, a series of suspended and wall hung paintings on plastic, Nursery of the Brave, a group of hanging vessels shaped from waste textiles, and Glass City, a video.

Christ And American Culture- Some Biblical Reflections, Paul Raabe

Concordia Pages

Going beyond H. Richard Neibuhr’s famous paradox model on “Christ and Culture,” Dr. Paul Raabe contends for a biblical, dynamic tension that exists between the culture and the faith. Using the image of a house, Raabe explores four “rooms” : (1) Christianity affirms culture in some respects; (2) Christianity opposes culture in some respects; (3) Christianity leavens culture in some ways; and (4) Christianity uses cultural forms to communicate its message. Each of the four rooms needs to be lived in for maintaining the tension presented in the Scriptures as a faithful witness to the lordship of Christ.

Ph-Responsive Liposomes Of Dioleoyl Phosphatidylethanolamine And Cholesteryl Hemisuccinate For The Enhanced Anticancer Efficacy Of Cisplatin, Hassan Shah, Asadullah Madni, Muhammad Muzamil Khan, Fiaz-Ud-Din Ahmad, Nasrullah Jan, Safiullah Khan, Muhammad Abdur Rahim, Shahzeb Khan, Meser M. Ali, Mohsin Kazi

Neurosurgery Articles

The current study aimed to develop pH-responsive cisplatin-loaded liposomes (CDDP@PLs) via the thin film hydration method. Formulations with varied ratios of dioleoyl phosphatidylethanolamine (DOPE) to cholesteryl hemisuccinate (CHEMS) were investigated to obtain the optimal particle size, zeta potential, entrapment efficiency, in vitro release profile, and stability. The particle size of the CDDP@PLs was in the range of 153.2 ± 3.08-206.4 ± 2.26 nm, zeta potential was -17.8 ± 1.26 to -24.6 ± 1.72, and PDI displayed an acceptable size distribution. Transmission electron microscopy revealed a spherical shape with ~200 nm size. Fourier transform infrared spectroscopic analysis showed the physicochemical stability …

Chronic Background Radiation Correlates With Sperm Swimming Endurance In Bank Voles From Chernobyl, Kati Kivisaari, Sara Calhim, Zbyszek Boratyríski, Timothy Mousseau, Anders P. Møller, Tapio Mappes

Faculty Publications

Sperm quantity and quality are key features explaining intra- and interspecific variation in male reproductive success. Spermatogenesis is sensitive to ionizing radiation and laboratory studies investigating acute effects of ionizing radiation have indeed found negative effects of radiation on sperm quantity and quality. In nature, levels of natural background radiation vary dramatically, and chronic effects of low-level background radiation exposure on spermatogenesis are poorly understood. The Chernobyl region offers a unique research opportunity for investigating effects of chronic low-level ionizing radiation on reproductive properties of wild organisms. We captured male bank voles (Myodes glareolus) from 24 locations in the Chernobyl …

Plasma Induced Reactive Oxygen Species-Dependent Cytotoxicity In Glioblastoma 3d Tumourspheres, Janith Wanigasekara, Carlos Barcia, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin

Articles

The aim of this study was to determine the effects of a pin‐to‐plate cold atmospheric plasma (CAP) on U‐251 MG three‐dimensional (3D) glioblastoma spheroids under different conditions. 3D tumorspheres showed higher resistance to the CAP treatment compared to 2D monolayer cells. A single CAP treatment was able to induce cytotoxicity, while multiple CAP treatments augmented this effect. CAP was also able to induce cytotoxicity throughout the tumoursphere, and we identified that reactive oxygen species(ROS) plays a major role, while H2O2plays a partial role in CAP‐induced cytotoxicity in tumour-spheres. We conclude that ROS‐dependent cytotoxicity is induced uniformly throughout glioblastoma and epidermoid …

Upregulation Of Cd36, A Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis By Increasing Mmp28 And Decreasing E-Cadherin Expression, James Drury, Piotr G. Rychahou, Courtney O. Kelson, Mariah E. Geisen, Yuanyuan Wu, Daheng He, Chi Wang, Eun Y. Lee, B. Mark Evers, Yekaterina Y. Zaytseva

Surgery Faculty Publications

Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC) cells with a higher metastatic potential express a higher level of fatty acid translocase (CD36). However, the role of CD36 in CRC metastasis has not been studied. Here, we demonstrate that high expression of CD36 promotes invasion of CRC cells. Consistently, CD36 promoted lung metastasis in the tail vein model and GI metastasis in the cecum injection model. RNA-Seq analysis of CRC cells with altered expression of CD36 revealed an association between high expression of CD36 and upregulation …

Thrombospondin-1 Expression And Modulation Of Wnt And Hippo Signaling Pathways During The Early Phase Of Trypanosoma Cruzi Infection Of Heart Endothelial Cells, Ashutosh Arun, Kayla J. Rayford, Ayorinde Cooley, Tanu Rana, Girish Rachakonda, Fernando Villalta, Siddharth Pratap, Maria F. Lima, Nader Sheibani, Pius N. Nde

Publications and Research

The protozoan parasite, Trypanosoma cruzi, causes severe morbidity and mortality in afflicted individuals. Approximately 30% of T. cruzi infected individuals present with cardiac pathology. The invasive forms of the parasite are carried in the vascular system to infect other cells of the body. During transportation, the molecular mechanisms by which the parasite signals and interact with host endothelial cells (EC) especially heart endothelium is currently unknown. The parasite increases host thrombospondin-1 (TSP1) expression and activates the Wnt/β-catenin and hippo signaling pathways during the early phase of infection. The links between TSP1 and activation of the signaling pathways and …

Illinois State University Salaries Fy2022, Illinois State University

Illinois State University Salaries

Includes two sections: non-tenure track, tenure track, and faculty associate salaries, and administrative professional and civil service salaries.

Ranging Patterns And Site Fidelity Of Snubfin Dolphins In Yawuru Nagulagun/Roebuck Bay, Western Australia, Alexandra D’Cruz, Chandra Salgado Kent, Kelly Waples, Alexander M. Brown, Sarah A. Marley, Deborah Thiele, Holly C. Raudino, Yawuru Native Title Prescribed Body Corporate, Broome, Wa, Australia

Research outputs 2022 to 2026

For long-lived species such as marine mammals, having sufficient data on ranging patterns and space use in a timescale suitable for population management and conservation can be difficult. Yawuru Nagulagun/Roebuck Bay in the northwest of Western Australia supports one of the largest known populations of Australian snubfin dolphins (Orcaella heinsohni)—a species with a limited distribution, vulnerable conservation status, and high cultural value. Understanding the species’ use of this area will inform management for the long-term conservation of this species. We combined 11 years of data collected from a variety of sources between 2007 and 2020 to assess the ranging patterns …

Evaluating A Targeted Cancer Therapy Approach Mediated By Rna, Katharina Woess, Yuchen Sun, Hanae Morio, Anna Stierschneider, Anna Kaufmann, Stefan Hainzl, Lisa Trattner, Thomas Kocher, Birgit Tockner, Victoria Leb-Reichl, Markus Steiner, Gabriele Brachtl, Andrew P. South, Johann W Bauer, Julia Reichelt, Tomomi Furihata, Verena Wally, Ulrich Koller, Josefina Piñón Hofbauer, Christina Guttmann-Gruber

Department of Dermatology and Cutaneous Biology Faculty Papers

Conventional anti-cancer therapies based on chemo- and/or radiotherapy represent highly effective means to kill cancer cells but lack tumor specificity and, therefore, result in a wide range of iatrogenic effects. A promising approach to overcome this obstacle is spliceosome-mediated RNA trans-splicing (SMaRT), which can be leveraged to target tumor cells while leaving normal cells unharmed. Notably, a previously established RNA trans-splicing molecule (RTM44) showed efficacy and specificity in exchanging the coding sequence of a cancer target gene (Ct-SLCO1B3) with the suicide gene HSV1-thymidine kinase in a colorectal cancer model, thereby rendering tumor cells sensitive to the prodrug ganciclovir (GCV). In …

Industry 4.0 Technologies For The Manufacturing And Distribution Of Covid-19 Vaccines, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Aminah Abdul Razzack, Shehar Bano, Sarabjot Singh Makkar, Sindhu Thevuthasan, Trissa Paul, Muhammad Khawar Sana, Nishwa Azeem

Department of Paediatrics and Child Health

Background: The evolutionary stages of manufacturing have led us to conceptualize the use of Industry 4.0 for COVID-19 (coronavirus disease 2019), powered by Industry 4.0 technologies. Using applications of integrated process optimizations reliant on digitized data, we propose novel intelligent networks along the vaccine value chain. Vaccine 4.0 may enable maintenance processes, streamline logistics, and enable optimal production of COVID-19 vaccines.
Vaccine 4.0 framework: The challenge in applying Vaccine 4.0 includes the requirement of large-scale technologies for digitally transforming manufacturing, producing, rolling-out, and distributing vaccines. With our framework, Vaccine 4.0 analytics will target process performance, process development, process stability, compliance, …

Estuarine Infauna Within Incidentally Retained Sediment In Artificial Rockpools, Jessica R. Bone, Rick Stafford, Alice E. Hall, Ian Boyd, Nigel George, Roger J.H. Herbert

School of Biological and Marine Sciences

Artificial coastal structures (ACSs) are primarily designed to provide services for human use, such as flood defence or shipping, and are generally poor for marine biodiversity. Consequently, there has been significant research effort to enhance these hard structures to increase biodiversity and habitat availability via eco-engineering. On seawalls and breakwaters, this has included the creation of habitats for benthic species found on natural rocky shores, including the provision of cracks, crevices and water retaining features, such as artificial rockpools. When sediment retention in these features has occurred, it has often been deemed detrimental to the overarching aim of the intervention. …

Aav5 Delivery Of Crispr-Cas9 Supports Effective Genome Editing In Mouse Lung Airway, Shun-Qing Liang, Christopher J Walkey, Alexa E Martinez, Qin Su, Mary E Dickinson, Dan Wang, William R Lagor, Jason D Heaney, Guangping Gao, Wen Xue

Faculty, Staff and Students Publications

Genome editing in the lung has the potential to provide long-term expression of therapeutic protein to treat lung genetic diseases. Yet efficient delivery of CRISPR to the lung remains a challenge. The NIH Somatic Cell Genome Editing (SCGE) Consortium is developing safe and effective methods for genome editing in disease tissues. Methods developed by consortium members are independently validated by the SCGE small animal testing center to establish rigor and reproducibility. We have developed and validated a dual adeno-associated virus (AAV) CRISPR platform that supports effective editing of a lox-stop-lox-Tomato reporter in mouse lung airway. After intratracheal injection of the …

Map Based Www Tool For Recommending Forage Species, M. H. Hall, D. A. Miller, J. H. Cherney

IGC Proceedings (1977-2023)

Selecting the “best” forage species or species mixture requires a knowledge and understanding of the consuming animal, soil characteristics, and forage species. The multivariate nature of the problem presents challenges to those interested in solving the practical problem of maximizing available resources. Earlier work at Cornell University resulted in a WWW-based interface that allowed the user to provide a soil type or zip code and additional management factors to initiate the species selection. This approach relies on either user knowledge of soil series or an implied relationship between zip code and soil series that may often be wrong. To improve …

Remote Sensing Application To Grassland Monitoring, Z. B. Nan

IGC Proceedings (1977-2023)

Application of remote sensing to the management of grassland resources, the role this plays in developing sustainable grassland farming systems and opportunities for further development are outlined. Use of remote sensing technologies in grassland monitoring has a history of more than 30 years. Both fine- and coarse-grained remote sensing techniques are used to monitor and study grasslands. Fine-grained techniques are used to study landscape scale processes through the use of sensors providing spatial resolution of a few meters, whereas coarse-grained techniques are used to study catchment scale areas, and even entire biomes, using satellite-based sensors with a spatial resolution of …

Modelling Grassland Ecosystems, J. H. M. Thornley

IGC Proceedings (1977-2023)

In this contribution a view of the promise and difficulties of modelling grassland is given. This is largely centred around work with a grassland ecosystem simulator known as the Hurley Pasture Model.

A brief introduction sets forth possible reasons for building a large ecosystem model, and stresses the importance of modelling objectives. It is suggested that a model is de rigeur for any research programme which aims to take a firm grasp of the complex responses of grassland. Mechanistic models are required to provide the understanding needed for intelligent and flexible management of grassland, whatever the prevailing environmental or economic …

Estimating Herbage Mass In Stargrass (Cynodon Nlenfuensis Var Nlenfuensis) Using Sward Surface Height And The Rising Plate Meter, D. E. Oliveira, S. R. Medeiros, L. J. M. Aroeira, L. G. Barioni, D. P. D. Lanna

IGC Proceedings (1977-2023)

Estimation of herbage mass is necessary both in research and farm management. Methods for such estimations should be inexpensive, rapid and reliable. Since estimations through hand clipping are time consuming, a range of indirect methods have been developed and tested in the literature. This study had the aim of comparing precision of two indirect methods, sward surface height (SSH) and the rising plate meter (RPM), to estimate herbage mass in stargrass pastures (Cynodon nlenfuensis var. nlenfuensis). Pre-grazing measurements of SSH and RPM readings were taken and compared with the paddock herbage mass. RPM readings were converted into centimeters. Average …

The Use Of Ruthenium Complexes As Molecular Probes For Non-Canonical Dna, Eleni Sullivan

SMU Journal of Undergraduate Research

This study considered the preparation of a new DNA binding Ruthenium polypyridyl complex possessing an infrared active nitrile group. The binding abilities of a novel Ruthenium complex, [Ru(TMP)₂DPPZ-10-CN], to various forms of DNA—both canonical and non-canonical—were examined by performing multiple DNA titrations. DNA is of great interest as it is the carrier of genetic information for all living things. Damage to DNA can have drastically detrimental effects, so the study of its structure and replication is of great importance. Two non-canonical structures that are important are the G-quadruplex and i-motif which form at the telomeric and regulatory regions …

Rushes Of Northcentral New Mexico, Madeline Payne

SMU Journal of Undergraduate Research

Juncaceae, otherwise known as rushes, are grass-like herbs that grow throughout North America in both arctic and temperate regions. The purpose of this monograph is to describe the 2 genera and 24 species of Juncaceae growing in northcentral New Mexico. Included is an introduction to the Juncaceae Family and the region of interest, reference maps, and a description of the materials and methods used to complete this research. Species description pages provide characteristics of the habit, leaves, flowers, fruit, and medicinal/culinary applications as well as pictures and diagrams. A key to the genera, keys to the species, a glossary, …

Book Reviews, Florida Historical Society

Florida Historical Quarterly

MARJORY STONEMAN DOUGLAS : VOICE OF THE RIVER : AN AUTOBIOGRAPHY WITH JOHN ROTHCHILD, by Marjory Stoneman Douglas, reviewed by LeRoy Collins; BOMBAST AND BROADSIDES: THE LIVES OF GEORGE JOHNSTONE, by Robin F. A. Fabel, reviewed by J. Barton Starr; YO SOLO: BERNARDO DE GÁLVEZ Y LA TOMA DE PANZACOLA EN 1781; UNA CONTRIBUCIÓ N ESPAÑOLA A LA INDEPENDENCIA DE LOS ESTADOS UNIDOS, by Carmen de Reparaz, reviewed by Joseph John Jova; FLORIDA'S VANISHING ARCHITECTURE, by Beth Dunlop, reviewed by Ivan A. Rodriguez; RECONSTRUCTING HISTORIC SUBSISTENCE WITH AN EXAMPLE FROM SIXTEENTH-CENTURY SPANISH FLORIDA, by Elizabeth J. Reitz and C. Margaret …

Demography And The Political Destiny Of Florida During The Second Spanish Period, Abel Poitrineau

Florida Historical Quarterly

The twenty-year period of British sovereignty of the Floridas came to an end September 3, 1783, when the treaty concluding the American Revolution was signed at Versailles, France. The Treaty of Paris, as it was known, gave the Spanish crown control of a large portion of North America. Spain retained sovereignty over the Louisiana Territory, and the Spanish flag once more flew over the Floridas as it had from 1565 to 1763. However, the restoration of Spanish rule in the Floridas, so important for the control of the Bahama Channel, was at best precarious. Spain’s military weakness and the financial …

"New Red Atlantis": John Collier's Encounter With The Florida Seminoles In 1935, Harry A. Kersey, Jr.

Florida Historical Quarterly

In March 1935, some two years following his appointment as commissioner of Indian Affairs by President Franklin D. Roosevelt, John Collier paid his first official visit to the Seminole Tribe in Florida. Although recognized as one of the nation’s leading Indian Rights advocates throughout the 1920s Collier’s work had been focused almost exclusively among the western tribes. As secretary of the American Indian Defense Association, he frequently appeared before various congressional committees, testifying on such issues as tribal water and mineral rights, control of reservation lands, and Indian religious freedom. His name had become synonymous with a progressive commitment to …

Daily Announcements January 2022, Wofford College. Office Of Marketing And Communications

Communications Office Daily Announcements

No abstract provided.

Bis-Amino Acid Based Compound And Use Thereof, George Gokel, Joseph W. Meisel, Mohit B. Patel

UMSL Patents

Compositions comprising bis(tryptophan) derivatives are provided that act as antimicrobials. Also provided are methods for reversing antibiotic resistance in a bacterium, or recovering or enhancing antimicrobial activity of an antibiotic against a variety of microbes, by co-administration with a bis(tryptophan) derivative.

Bremelanotide For Treatment Of Female Hypoactive Sexual Desire, Amber N. Edinoff, Nicole M. Sanders, Kyle B. Lewis, Tucker L. Apgar, Elyse M. Cornett, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Hypoactive sexual desire disorder (HSDD) is a persistent deficiency or absence of sexual fantasies and desire resulting in significant distress or interpersonal difficulty. Women with this disorder may display a lack of motivation for sexual activity, reduced responsiveness to erotic cues, a loss of interest during sexual activity, and avoidance of situations that could lead to sexual activity. The pathophysiology of HSDD is thought to be centered around inhibitory and excitatory hormones, neurotransmitters, and specific brain anatomy. Due to the multifactorial nature of HSDD, treatment can be complex and must attempt to target the biological and psychosocial aspects of the …

Effects Of Melatonin And Flaxseeds Oil On Oxidative Stress And Inflammatory Parameters In Type 2 Diabetic Patients, Haitham Kadhim, Arwa Al-Shuwiakh, Noor Ali, Faruk Aljawad, Hashim Hashim, Ashwaq Gorji

Journal of Applied Sciences and Nanotechnology

In patients with diabetes, chronic inflammation is characterised by the increase in C-reactive protein (CRP) and tumour necrosis alpha (TNF-α). The consumption of melatonin and flaxseed oil may improve insulin sensitivity and the effectiveness of diabetic medications. The current study investigated the efficacy of melatonin and flaxseed oil in patients with Type 2 diabetes mellitus (T2DM). It involved 43 patients with diabetes who were divided into 3 groups. The first group received a placebo (starch 50mg, n=13), the second group received melatonin (10mg per day, n=14) and the third group received flaxseed oil (1000mg per day, n=16), in addition to …

Lack Of Knowledge Is The Leading Key For The Growing Cervical Cancer Incidents In Bangladesh: A Population Based, Cross-Sectional Study, Nur E. Alam, Md. Shariful Islam, Fabia Rayyan, Humaira Nur Ifa, Md. Imam Ul Khabir, Kamal Chowdhury, A. K. M. Mohiuddin

Biology Graduate Research

Introduction

Cervical cancer is the second most common gynecological cancer in Bangladesh. Lack of awareness of screening methods, risk factors, and symptoms may lead to presenting most cervical cancers at an advanced stage. We investigated knowledge and awareness of cervical cancer (CCa) among females at the Sheikh Hasina Medical College (SHMC) of Tangail district in Bangladesh.

Methods

A cross sectional survey was conducted to collect data via a structured questionnaire from SHMC during the period of February 2019 to January 2020. Data on socio-demographic characteristics and knowledge of cervical cancer were collected. Multivariable logistic regression models were used to identify …