Digital Commons Network^™

Detecting Anomalies In Retinal Diseases Using Generative, Discriminative, And Self-Supervised Deep Learning, Philippe Burlina, William Paul, T Y Alvin Liu, Neil M Bressler

Faculty, Staff and Students Publications

IMPORTANCE: Anomaly detectors could be pursued for retinal diagnoses based on artificial intelligence systems that may not have access to training examples for all retinal diseases in all phenotypic presentations. Possible applications could include screening of population for any retinal disease rather than a specific disease such as diabetic retinopathy, detection of novel retinal diseases or novel presentations of common retinal diseases, and detection of rare diseases with little or no data available for training.

OBJECTIVE: To study the application of anomaly detection to retinal diseases.

DESIGN, SETTING, AND PARTICIPANTS: High-resolution retinal images from the publicly available EyePACS data set …

Race/Ethnicity And Birthplace As Risk Factors For Gastric Intestinal Metaplasia In A Multiethnic United States Population, Mimi C Tan, Taher Jamali, Theresa H Nguyen, Amy Galvan, Robert J Sealock, Anam Khan, Neda Zarrin-Khameh, Ashley Holloman, Ourania Kampagianni, David Henriquez Ticas, Yan Liu, Hashem B El-Serag, Aaron P Thrift

Faculty, Staff and Students Publications

INTRODUCTION: Several US subgroups have increased risk of gastric cancer and gastric intestinal metaplasia (GIM) and may benefit from targeted screening. We evaluated demographic and clinical risk factors for GIM and examined the interaction between race/ethnicity and birthplace on GIM risk.

METHODS: We identified patients who had undergone esophagogastroduodenoscopy with gastric biopsy from 3/2006-11/2016 using the pathology database at a safety net hospital in Houston, Texas. Cases had GIM on ≥1 gastric biopsy histopathology, whereas controls lacked GIM on any biopsy. We estimated odds ratios and 95% confidence intervals (CI) for associations with GIM risk using logistic regression and developed …

Maximum Dose Food Challenges Reveal Transient Sustained Unresponsiveness In Peanut Oral Immunotherapy (Poimd Study), Carla M Davis, Aikaterini Anagnostou, Sridevi Devaraj, Daisy T Vita, Fabian Rivera, Kathleen Pitts, Melissa Hearrell, Charles Minard, Danielle Guffey, Meera Gupta, Levi Watkin, Jordan S Orange, Sara Anvari

Faculty, Staff and Students Publications

BACKGROUND: The maximum tolerated dose of peanut protein following peanut oral immunotherapy (POIT) is unknown because most research studies have not examined very high thresholds.

OBJECTIVE: To define the maximum dose tolerated by patients on POIT and severity of allergic reactions after a 1-month period of treatment discontinuation.

METHODS: In a phase 2 3-year POIT open-label study, we enrolled participants age 5 to 13 years with a 1-year build-up period followed by a 2-year daily maintenance dose of 3900 mg with assessment of the maximum tolerated dose using double-blind placebo-controlled food challenges (DBPCFCs) of 26,225 mg cumulative dose of peanut …

Review Of Gene Therapies For Age-Related Macular Degeneration, Arshad M Khanani, Mathew J Thomas, Aamir A Aziz, Christina Y Weng, Carl J Danzig, Glenn Yiu, Szilárd Kiss, Nadia K Waheed, Peter K Kaiser

Faculty, Staff and Students Publications

Gene therapies aim to deliver a therapeutic payload to specified tissues with underlying protein deficiency. Since the 1990s, gene therapies have been explored as potential treatments for chronic conditions requiring lifetime care and medical management. Ocular gene therapies target a range of ocular disorders, but retinal diseases are of particular importance due to the prevalence of retinal disease and the current treatment burden of such diseases on affected patients, as well as the challenge of properly delivering these therapies to the target tissue. The purpose of this review is to provide an update on the most current data available for …

Metabolism Of A Selective Serotonin And Norepinephrine Reuptake Inhibitor Duloxetine In Liver Microsomes And Mice, Xuan Qin, John M Hakenjos, Kevin R Mackenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M Matzuk, Feng Li

Faculty, Staff and Students Publications

Duloxetine (DLX) is a dual serotonin and norepinephrine reuptake inhibitor, widely used for the treatment of major depressive disorder. Although DLX has shown good efficacy and safety, serious adverse effects (e.g., liver injury) have been reported. The mechanisms associated with DLX-induced toxicity remain elusive. Drug metabolism plays critical roles in drug safety and efficacy. However, the metabolic profile of DLX in mice is not available, although mice serve as commonly used animal models for mechanistic studies of drug-induced adverse effects. Our study revealed 39 DLX metabolites in human/mouse liver microsomes and mice. Of note, 13 metabolites are novel, including five …

Age-Associated Gut Dysbiosis, Marked By Loss Of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites In Older People Living With Hiv, Smita Ghare, Richa Singhal, Vaughn Bryant, Sabina Gautam, Chanakya Charan Tirumala, Praneet Kumar Srisailam, Andrea Reyes-Vega, Dushan Ghooray, Craig J Mcclain, Kristi Hoffman, Joseph Petrosino, Kendall Bryant, Varan Govind, Ronald Cohen, Robert L Cook, Shirish Barve

Faculty, Staff and Students Publications

BACKGROUND: Imbalance in tryptophan (TRP) metabolism and its neuroactive metabolites, serotonin and kynurenine (KYN), is a known pathogenic mechanism underlying neurocognitive impairment. Gut microbiota plays an important role in TRP metabolism, and the production of these neuroactive molecules affects neurocognitive function. Although both HIV infection and normal aging independently induce gut dysbiosis and influence TRP metabolism, their interactive effects on compositional/functional changes in gut microbiota and consequent alterations in TRP metabolites remain largely undetermined.

METHODS: Older people living with HIV infection (PLWH, aged 50-70 years, n = 22) were enrolled in this cross-sectional pilot study. Metagenomic analysis of fecal microbiome …

Isa101 And Nivolumab For Hpv-16+ Cancer: Updated Clinical Efficacy And Immune Correlates Of Response, Luana Guimaraes De Sousa, Kimal Rajapakshe, Jaime Rodriguez Canales, Renee L Chin, Lei Feng, Qi Wang, Tomas Z Barrese, Erminia Massarelli, William William, Faye M Johnson, Renata Ferrarotto, Ignacio Wistuba, Cristian Coarfa, Jack Lee, Jing Wang, Cornelis J M Melief, Michael A Curran, Bonnie S Glisson

Faculty, Staff and Students Publications

BACKGROUND: The combination of ISA101, a human papilloma virus (HPV) 16 peptide vaccine, and nivolumab showed a promising response rate of 33% in patients with incurable HPV-16+ cancer. Here we report long-term clinical outcomes and immune correlates of response.

METHODS: Patients with advanced HPV-16+ cancer and less than two prior regimens for recurrence were enrolled to receive ISA101 (100 µg/peptide) on days 1, 22, and 50 and nivolumab 3 mg/kg every 2 weeks beginning day 8 for up to 1 year. Baseline tumor samples were stained with multiplex immunofluorescence for programmed death-ligand 1 (PD-L1), programmed cell death protein-1 (PD-1), CD3, …

K-Ras And P53 Mouse Model With Molecular Characteristics Of Human Rhabdomyosarcoma And Translational Applications, Kengo Nakahata, Brian W Simons, Enrico Pozzo, Ryan Shuck, Lyazat Kurenbekova, Zachary Prudowsky, Kshiti Dholakia, Cristian Coarfa, Tajhal D Patel, Lawrence A Donehower, Jason T Yustein

Faculty, Staff and Students Publications

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, with overall long-term survival rates of ∼65-70%. Thus, additional molecular insights and representative models are critical for identifying and evaluating new treatment modalities. Using MyoD-Cre-mediated introduction of mutant K-RasG12D and perturbations in p53, we developed a novel genetically engineered mouse model (GEMM) for RMS. The anatomic sites of primary RMS development recapitulated human disease, including tumors in the head, neck, extremities and abdomen. We confirmed RMS histology and diagnosis through Hematoxylin and Eosin staining, and positive immunohistochemical staining for desmin, myogenin, and phosphotungstic acid-Hematoxylin. Cell lines from GEMM tumors …

Quality Control For Single Cell Imaging Analytics Using Endocrine Disruptor-Induced Changes In Estrogen Receptor Expression, Fabio Stossi, Pankaj K Singh, Ragini M Mistry, Hannah L Johnson, Radhika D Dandekar, Maureen G Mancini, Adam T Szafran, Arvind U Rao, Michael A Mancini

Faculty, Staff and Students Publications

BACKGROUND: Diverse toxicants and mixtures that affect hormone responsive cells [endocrine disrupting chemicals (EDCs)] are highly pervasive in the environment and are directly linked to human disease. They often target the nuclear receptor family of transcription factors modulating their levels and activity. Many high-throughput assays have been developed to query such toxicants; however, single-cell analysis of EDC effects on endogenous receptors has been missing, in part due to the lack of quality control metrics to reproducibly measure cell-to-cell variability in responses.

OBJECTIVE: We began by developing single-cell imaging and informatic workflows to query whether the single cell distribution of the …

Comparative Performance Of Risk Prediction Models For Hepatitis B-Related Hepatocellular Carcinoma In The United States, Hyun-Seok Kim, Xian Yu, Jennifer Kramer, Aaron P Thrift, Pete Richardson, Yao-Chun Hsu, Avegail Flores, Hashem B El-Serag, Fasiha Kanwal

Faculty, Staff and Students Publications

BACKGROUND & AIMS: Guidelines recommend hepatocellular carcinoma (HCC) surveillance in patients with chronic HBV infection. Several HCC risk prediction models are available to guide surveillance decisions, but their comparative performance remains unclear.

METHODS: Using a retrospective cohort of patients with HBV treated with nucleos(t)ide analogues at 130 Veterans Administration facilities between 9/1/2008 and 12/31/2018, we calculated risk scores from 10 HCC risk prediction models (REACH-B, PAGE-B, m-PAGE-B, CU-HCC, HCC-RESCUE, CAMD, APA-B, REAL-B, AASL-HCC, RWS-HCC). We estimated the models' discrimination and calibration. We calculated HCC incidence in risk categories defined by the reported cut-offs for all models.

RESULTS: Of 3,101 patients …

Randomized Phase Iii Bmt Ctn Trial Of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions In Myeloablative Hematopoietic Cell Transplantation For Hematologic Malignancies, Leo Luznik, Marcelo C Pasquini, Brent Logan, Robert J Soiffer, Juan Wu, Steven M Devine, Nancy Geller, Sergio Giralt, Helen E Heslop, Mary M Horowitz, Richard J Jones, Mark R Litzow, Adam Mendizabal, Lori Muffly, Eneida R Nemecek, Lynn O'Donnell, Richard J O'Reilly, Raquel Palencia, Johannes Schetelig, Leyla Shune, Scott R Solomon, Sumithira Vasu, Vincent T Ho, Miguel-Angel Perales

Faculty, Staff and Students Publications

PURPOSE: Calcineurin inhibitors (CNI) are standard components of graft-versus-host disease (GVHD) prophylaxis after hematopoietic cell transplantation (HCT). Prior data suggested that CNI-free approaches using donor T-cell depletion, either by ex vivo CD34 selection or in vivo post-transplant cyclophosphamide (PTCy) as a single agent, are associated with lower rates of chronic GVHD (cGVHD).

METHODS: This multicenter phase III trial randomly assigned patients with acute leukemia or myelodysplasia and an HLA-matched donor to receive CD34-selected peripheral blood stem cell, PTCy after a bone marrow (BM) graft, or tacrolimus and methotrexate after BM graft (control). The primary end point was cGVHD (moderate or …

Fractality Of Tics As A Quantitative Assessment Tool For Tourette Syndrome, Payton Beeler, Nicholas O Jensen, Soyoung Kim, Amy Robichaux-Viehoever, Bradley L Schlaggar, Deanna J Greene, Kevin J. Black, Rajan K Chakrabarty

2020-Current year OA Pubs

Tics manifest as brief, purposeless and unintentional movements or noises that, for many individuals, can be suppressed temporarily with effort. Previous work has hypothesized that the chaotic temporal nature of tics could possess an inherent fractality, that is, have neighbour-to-neighbour correlation at all levels of timescale. However, demonstrating this phenomenon has eluded researchers for more than two decades, primarily because of the challenges associated with estimating the scale-invariant, power law exponent-called the fractal dimension

Determining Yield Effects Of Simulated Stand Loss In Field Corn (Zea Mays), T. B. Towles, A. L. Catchot, J. Gore, D. R. Cook, M. A. Caprio, C. Daves, W. D. Crow, B. Thrash, B. Thrash, N. R. Bateman

Midsouth Entomologist

The corn borer complex, consisting of Diatraea grandiosella (Dyar), Ostrinia nubilalis (Hübner), and D. saccharalis (F.), poses a risk to field corn that is not protected through the use of foliar-applied insecticides or Bacillus thuringiensis (Bt) proteins incorporated into the plant's genetics. In the southern U.S., corn borers have been adequately controlled through the widespread planting of Bt corn hybrids. Refuge systems have been implemented to prevent the selection of Bt-resistant populations in target species. Historically, structured refuge compliance among corn producers has been low, leading to the commercialization of seed blended refugia in areas of the U.S. where cotton …

Abstracts Of The 11th Annual Mississippi Association Of Entomologists, Nematologists, And Plant Pathologists Meeting, October 31 – November 1, 2022, Mississippi Association Of Entomologists, Nematologists, And Plant Pathologists

Midsouth Entomologist

No abstract provided.

Mental Health In The Uk Biobank: A Roadmap To Self-Report Measures And Neuroimaging Correlates, Rosie K Dutt, Kayla Hannon, Ty O Easley, Joseph C Griffis, Wei Zhang, Janine D Bijsterbosch

2020-Current year OA Pubs

The UK Biobank (UKB) is a highly promising dataset for brain biomarker research into population mental health due to its unprecedented sample size and extensive phenotypic, imaging, and biological measurements. In this study, we aimed to provide a shared foundation for UKB neuroimaging research into mental health with a focus on anxiety and depression. We compared UKB self-report measures and revealed important timing effects between scan acquisition and separate online acquisition of some mental health measures. To overcome these timing effects, we introduced and validated the Recent Depressive Symptoms (RDS-4) score which we recommend for state-dependent and longitudinal research in …

Innovations In Surgery Between The Past And Future: A Narrative Review Of Targeted Literature, Obada Hasan, Ahmed Ayaz, Laiba Masood, Abdul Mannan Baig, Naveed Baloch

Medical College Documents

Innovation is the introduction of a new method or technology designed to change the way things are done. History is full of remarkable innovations in surgery over the years as surgeons have always been innovating and pioneering latest techniques and equipment that can benefit the mankind. Though persistent, progress has been far from uniform. Despite all the bells and whistles that these innovations bring to the table, the little acknowledged fact is that they are only accessible to a very small proportion of the global population. Five billion people on this planet do not even have access to an operating …

Imidazole Derivative Improves Antioxidant Status And Causes Differential Alteration Of Redox-Status In Drosophila Melanogaster, Elizabeth Temidayo Oluwayemi, Oluwakemi Josephine Awakan, Abiodun Omokehinde Eseola, Winfried Plass, Oluyomi Stephen Adeyemi

Karbala International Journal of Modern Science

This study investigated the toxicity of a new imidazole compound, 1-(1,4,5-triphenyl-1H-imidazol-2-yl)-naphthalen-2-ol, through the evaluation of selected oxidative stress markers and antioxidants. Both male and female D. melanogaster (3–5 days old) were fed a diet containing the imidazole derivative (20, 50, and 100 mg IMZ/kg diet) for five days. After cessation of imidazole treatment, half the population of the imidazole-exposed flies was homogenized for biochemical assays, while the other half of the flies was allowed to have a normal diet for an additional five days to see if any induced effect would be resolved. Imidazole derivatives did not significantly …

Glcms Based Multi-Inputs 1d Cnn Deep Learning Neural Network For Covid-19 Texture Feature Extraction And Classification, Elaf Ali Abbood, Tawfiq A. Al-Assadi

Karbala International Journal of Modern Science

Coronavirus disease 2019 epidemic (COVID-19) is an infectious disease that appeared because of the newest version of discovered coronavirus. The advent and rapid spread of this disease over the world necessitated a concerted effort to contain and eradicate it. Computer Tomography (CT) imaging and X-Ray images are considered as one of the important medical examinations used for disease diagnosis. To speed up and confirm the correctness of the medical diagnosis, many artificial intelligence techniques and machine learning methods are proposed. In this paper, a new and efficient proposed system is introduced to extract appropriate and meaningful features for CT scans …

A Convenient Green Method To Synthesize Β-Carotene From Edible Carrot And Nanoparticle Formation, Baker A. Joda, Zena M. Abed Al-Kadhim, Hussian J. Ahmed, Alaa K. H. Al-Khalaf

Karbala International Journal of Modern Science

A simple green chemistry approach was used to synthesize β-carotene from edible carrot without using solvent and heat. In this study, beta-carotene was extracted from edible carrots through a natural extraction method with several physical technical steps. The extracted sample was isolated using high-performance liquid chromatography (HPLC). A β-carotene peak was detected from HPLC with an absorbance maximum (2.135 mAU). The absorption of UV-Visible spectrum indicated that beta-carotene absorbs most strongly between 230-300 and 400-500 nm. The functional groups, namely, C=C (1649 cm^-1), =C-H (900-900 cm^-1) vibrations of antisymmetric deformation of CH₃ groups and CH …

Perceptions On Governance For Effective Adaptation To Climate Change Within Community-Based Wildlife Conservancies In Kenya, S. Kibet, Oliver Vivian Wasonga

IGC Proceedings (1977-2023)

Community-based wildlife conservancies (CBC) represent a broad spectrum of new management arrangements and benefit sharing partnerships in natural resource management by none state agents, but who, by virtue of their collective location and activities, are critically placed to shape the present and future status of these resources. This approach of wildlife management is increasingly gaining popularity as an option for achieving sustainable co-existence and complementarity between wildlife conservation and livestock production in the drylands of Kenya. Despite difference in ownership and governance structure in place, all conservancies have instituted new rules of control and access. This study sought to understand …

The Cleaned Approach For Flagging And Addressing Environmental Issues, A. Notenbaert, B. Paul, R. Van Der Hoek, J. Mukiri

IGC Proceedings (1977-2023)

While livestock presents an important livelihood strategy for many smallholders, it is also held responsible for important environmental impacts. In this paper, we used an online survey to identify the perceptions of global livestock experts on environmental impacts of livestock and how these might be tackled. We then explored how the CLEANED environmental ex-ante assessment tool (Comprehensive Livestock Environmental Assessment for improved Nutrition, a secured Environment and sustainable Development = CLEANED) responds to this and how it can be used to influence decision making towards more environmentally-friendly livestock production.

According to the survey, there was general agreement between researchers, development …

Survey Of The Farm Management, Focusing On The Regional Difference And Cattle Farming In Burkina Faso, H. Kumagai, T. Kawashima, A. Sienou, F. Nagumo

IGC Proceedings (1977-2023)

In Burkina Faso the history using of cattle as draft power for cultivation is not long. This study was conducted to investigate the farm management, focusing on the regional difference and the presence of cattle farming in the country. Interview was carried out on 30 farms from B Province in the Centre-West Region consisting of 8 non-cattle owners (BNs) and 22 cattle owners (BCs), and on 9 farms of cattle owners from H Province in the Haut-Bassins Region (HCs) in November 2013. The average household sizes of BNs, BCs and HCs were 16.5, 27.2 and 31.3, respectively. The ratios of …

Sowing Date Affects Dry Matter Yield Of Fodder Beet (Beta Vulgaris L.) Crops And Farm Profitability, Edith N. Khaembah, John M. De Ruiter, S. Maley

IGC Proceedings (1977-2023)

Fodder beet (Beta vulgaris L.) is a high yielding and high energy supplementary ruminant feed. Including the crop in a pasture system means loss in production and additional costs during crop establishment, but economic benefits may be recovered with increased seasonal productivity and feed quality. In this study, the Agricultural Production Systems sIMulator was used to estimate herbage production of a typical dairy farm in the Canterbury region of New Zealand based on using a ryegrass (Lolium perenne L.)-clover (Trifolium repens L.) pasture (“Pasture only”) or pasture in combination with fodder beet …

The Rise Of Community-Based Natural Resource Management Strategies As Explained By Transaction Costs, Keely A. Fisher, Marc R. Donnelly, Collin Adams

Undergraduate Economic Review

Community-based natural resource management (CBNRM) is favored over its predecessor, the fortress approach, for common pool resource (CPR) management. We strive to identify variables associated with successful CBNRM programs, and analyze whether their presence transaction costs can explain the shift in favored conservation strategy. By examining nine case studies of large mammals in Africa, we found that out of eight variables, moderate monitoring and adequate program incentives were the most critical various factors in determining CBNRM program outcomes. Furthermore, these variables, as well as others, contributed to a decrease in transaction costs.

Book Review: Reckonings: Numerals, Cognition, And History By Stephen Chrisomalis, Milton Rosa, Daniel Clark Orey

Journal of Humanistic Mathematics

This review of Reckonings shares our thoughts on the diverse insights presented by Stephen Chrisomalis’s version of the history of numerical notation. Chrisomalis suggests that members of distinct cultural groups write numbers as an active choice in accordance with their own sociocultural contexts, which reflect the influences of historical, cognitive, social, economic, political, environmental, and cultural factors. This book integrates comparative, cognitive, and evolutionary understandings on numerical cognition with historical and linguistic evidence on the use and transformation of numeral systems through the historical advancement of numeracy. Chrisomalis offers an interesting historical perspective on numbers that builds upon three main …

Mathematics For The Masses: Door-To-Door Missionaries Of Math And Twelve-Step Recovery Programs, Daniel S. Helman

Journal of Humanistic Mathematics

Conversion of strangers, or proselytizing, is a feature of a range of groups for religious, organizational and other aims. In twelve-step recovery programs, such as Alcoholics Anonymous, belief in a higher power is a requirement for working the steps to recovery. People are encouraged to find a higher power of their own understanding. This paper presents a model for using mathematics as a higher power, and shows how recovery works with mathematics in that role instead of a more traditional higher power such as God. A contemplative definition of math is given along with a description of a three-categoried epistemology: …

An Urgent Plea For More Graduate Programs In Statistics Education, David Eli Drew, Sam Behseta, Cherie L. Ichinose

Journal of Humanistic Mathematics

Lately, much has been written about the importance of amplifying statistics-related content in the K-12 curricula. This can be viewed in parallel or as an addendum to the existing mathematics curricula in the United States. Nevertheless, a key component of this debate is the lack of robust and cutting-edge academic programs in statistics education. In this piece, we emphasize the urgent need for investing in creating strong statistics education programs, which would significantly contribute to nurturing quantitative literacy as well as preparing a more informed citizenry in the 21^st century.

Machine Learning-Based Soft Computing Regression Analysis Approach For Crime Data Prediction, Rabia Musheer Aziz, Aftab Hussain, Prajwal Sharma, Pavan Kumar

Karbala International Journal of Modern Science

The crime rate in India is considerably increasing day by day. Consequently, the data associated with crime is also increasing, opening doors for data-driven approaches to these data to extract insightful knowledge, which can help police and other law enforcement organizations of the country in crime control and prevention. Crime prediction using machine learning algorithms on crime data can predict region-wise crime counts. In this paper, a machine learning-based soft computing regression analysis approach for Indian Crime Data Analysis (ICDA) is proposed. Different regression algorithms, namely, Simple Linear Regression (SLR), Multiple Linear Regression (MLR), Decision Tree Regression (DTR), Support Vector …

Enhancing Counselor Education And Supervision Through Deliberate Practice, Zach Budesa, Casey A. Barrio Minton

Teaching and Supervision in Counseling

Abstract: Professional and student counselors must develop and maintain their counseling skills in order to engage in ethical and effective counseling. Recent research suggests that graduate education and supervision has little effect on client outcomes. Investigations of expertise development have given rise to deliberate practice, a framework which structures skill development research and instruction. Deliberate practice involves individualized coaching, repetition, and solo practice in development of optimal performance. This conceptual article introduces deliberate practice as a framework for enhancing effectiveness of counselor education and supervision practices. Applications of deliberate practice to teaching and supervision and suggestions for future research are …

Developing A Flapping Gear System For Butterfly-Inspired Motion, Frederick Schulze, Chang-Kwon Kang

AIAA Southeastern Regional Student Conference

Bioinspired flapping-wing drones have the potential to revolutionize data collection techniques with increased versatility and performance over existing rotary and fixed-wing drone types. Their capability for increased power efficiency is demonstrated in the long-range migration of Monarch butterflies. However, the wing motion is more complicated, resulting in three-dimensional wing kinematics. To better understand the performance of these wings, a flapping wing gear system is developed to reproduce the flapping motion of a monarch butterfly. The mechanism consists of a two-stage gear reduction and a 4-bar linkage to convert rotary motion to flapping motion. A dynamic analysis performed on the proposed …