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Articles 22411 - 22440 of 32057
Full-Text Articles in Entire DC Network
Craniofacial Fluctuating Asymmetry In Gorillas, Chimpanzees, And Macaques, Ashly N. Romero, D. Rex Mitchell, Siobhán B. Cooke, Claire A. Kirchhoff, Claire E. Terhune
Craniofacial Fluctuating Asymmetry In Gorillas, Chimpanzees, And Macaques, Ashly N. Romero, D. Rex Mitchell, Siobhán B. Cooke, Claire A. Kirchhoff, Claire E. Terhune
Biomedical Sciences Faculty Research and Publications
Objectives
Craniofacial fluctuating asymmetry (FA) refers to the random deviations from symmetry exhibited across the craniofacial complex and can be used as a measure of developmental instability for organisms with bilateral symmetry. This article addresses the lack of data on craniofacial FA in nonhuman primates by analyzing FA magnitude and variation in chimpanzees, gorillas, and macaques. We offer a preliminary investigation into how FA, as a proxy for developmental instability, varies within and among nonhuman primates.
Materials and Methods
We generated 3D surface models of 121 crania from Pan troglodytes troglodytes, Gorilla gorilla gorilla, and Macaca fascicularis fascicularis …
Clinical And Molecular Characterization Of Pole Mutations As Predictive Biomarkers Of Response To Immune Checkpoint Inhibitors In Advanced Cancers, Benjamin Garmezy, Jinesh Gheeya, Heather Y Lin, Yuefan Huang, Taebeom Kim, Xianli Jiang, Kyaw Z Thein, Patrick G Pilié, Fadl Zeineddine, Wanlin Wang, Kenna R Shaw, Jordi Rodon, John Paul Shen, Ying Yuan, Funda Meric-Bernstam, Ken Chen, Timothy A Yap
Clinical And Molecular Characterization Of Pole Mutations As Predictive Biomarkers Of Response To Immune Checkpoint Inhibitors In Advanced Cancers, Benjamin Garmezy, Jinesh Gheeya, Heather Y Lin, Yuefan Huang, Taebeom Kim, Xianli Jiang, Kyaw Z Thein, Patrick G Pilié, Fadl Zeineddine, Wanlin Wang, Kenna R Shaw, Jordi Rodon, John Paul Shen, Ying Yuan, Funda Meric-Bernstam, Ken Chen, Timothy A Yap
Faculty, Staff and Student Publications
Purpose: DNA polymerase epsilon is critical to DNA proofreading and replication. Mutations in POLE have been associated with hypermutated tumors and antitumor response to immune checkpoint inhibitor (ICI) therapy. We present a clinicopathologic analysis of patients with advanced cancers harboring POLE mutations, the pattern of co-occurring mutations, and their response to ICI therapy within the context of mutation pathogenicity.
Methods: We conducted a retrospective analysis of next-generation sequencing data at MD Anderson Cancer Center to identify patient tumors with POLE mutations and their co-occurring mutations. The pathogenicity of each mutation was annotated using InterVar and ClinVar. Differences in therapeutic response …
Ces2 Sustains Hnf4Α Expression To Promote Pancreatic Adenocarcinoma Progression Through An Epoxide Hydrolase-Dependent Regulatory Loop, Yihui Chen, Michela Capello, Mayrim V Rios Perez, Jody V Vykoukal, David Roife, Ya'an Kang, Laura R Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L Baluya, Jennifer B Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J Chiao, Matthew H G Katz, Jason B Fleming, Samir M Hanash, Johannes F Fahrmann
Ces2 Sustains Hnf4Α Expression To Promote Pancreatic Adenocarcinoma Progression Through An Epoxide Hydrolase-Dependent Regulatory Loop, Yihui Chen, Michela Capello, Mayrim V Rios Perez, Jody V Vykoukal, David Roife, Ya'an Kang, Laura R Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L Baluya, Jennifer B Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J Chiao, Matthew H G Katz, Jason B Fleming, Samir M Hanash, Johannes F Fahrmann
Faculty, Staff and Student Publications
Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation, downstream effects, and contribution to tumor development in PDAC.
Methods: Association between the mRNA expression of CES2 in pancreatic tumors and overall survival was assessed using The Cancer Genome Atlas. Cell viability, clonogenic, and anchorage-independent growth assays as well as an orthotopic mouse model of PDAC were used to evaluate the biological relevance of CES2 in pancreatic cancer. CES2-driven metabolic changes were determined by untargeted and targeted …
Effects Of Placebo Administration On Immune Mechanisms And Relationships With Central Endogenous Opioid Neurotransmission, Alan Prossin, Alisa Koch, Phillip Campbell, Geoffroy Laumet, Christian S Stohler, Robert Dantzer, Jon-Kar Zubieta
Effects Of Placebo Administration On Immune Mechanisms And Relationships With Central Endogenous Opioid Neurotransmission, Alan Prossin, Alisa Koch, Phillip Campbell, Geoffroy Laumet, Christian S Stohler, Robert Dantzer, Jon-Kar Zubieta
Faculty, Staff and Student Publications
Behavioral conditioning and expectation can have profound impact on animal and human physiology. Placebo, administered under positive expectation in clinical trials, can have potent effects on disease pathology, obscuring active medications. Emerging evidence suggests placebo-responsive neurotransmitter systems (e.g., endogenous opioid) regulate immune function by manipulating inflammatory proteins including IL-18, a potent pro-inflammatory, nociceptive cytokine implicated in pathophysiology of various diseases. Validation that neuroimmune interactions involving brain μ-opioid receptor (MOR) activity and plasma IL-18 underlie placebo analgesic expectation could have widespread clinical applications. Unfortunately, current lack of mechanistic clarity obfuscates clinical translation. To elucidate neuroimmune interactions underlying placebo analgesia, we exposed …
Neur 491.01: Neuroanatomy, Katie Marie Holick
Neur 491.01: Neuroanatomy, Katie Marie Holick
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Neur 391.01: Neural Systems Of Behavior & Cognition, Nathan E. Insel
Neur 391.01: Neural Systems Of Behavior & Cognition, Nathan E. Insel
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Ensc 105n.01: Environmental Science, Marilyn J. Marler
Ensc 105n.01: Environmental Science, Marilyn J. Marler
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Ensc 470.01: Agroecology, Caroline Muir Stephens
Ensc 470.01: Agroecology, Caroline Muir Stephens
University of Montana Course Syllabi, 2021-2025
No abstract provided.
M 414.01: Deterministic Models, Emily F. Stone
M 414.01: Deterministic Models, Emily F. Stone
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Psyx 233.50: Fundamentals Of The Psychology Of Aging, Amy E. Violante
Psyx 233.50: Fundamentals Of The Psychology Of Aging, Amy E. Violante
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Psyx 330.50: Child Development, Jennifer L. Rotzal
Psyx 330.50: Child Development, Jennifer L. Rotzal
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Psyx 356.R01: Human Neuropsychology, Robert Stuart Halll
Psyx 356.R01: Human Neuropsychology, Robert Stuart Halll
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 101h.03: Anthropology And The Human Experience, Cheyenne L. Laue
Anty 101h.03: Anthropology And The Human Experience, Cheyenne L. Laue
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 101h.51: Anthropology And The Human Experience, Cheyenne L. Laue
Anty 101h.51: Anthropology And The Human Experience, Cheyenne L. Laue
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Biob 101n.01: Discover Biology, Gregory D. Peters
Biob 101n.01: Discover Biology, Gregory D. Peters
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Biob 109n.00: Montana Ecosystems, Gregory D. Peters
Biob 109n.00: Montana Ecosystems, Gregory D. Peters
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Biob 210n.50: Communicating Biology, Gregory D. Peters
Biob 210n.50: Communicating Biology, Gregory D. Peters
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Psyx 100s.50: Introduction To Psychology, Jessica Kathleen Kumm
Psyx 100s.50: Introduction To Psychology, Jessica Kathleen Kumm
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 101h.02: Anthropology And The Human Experience, David Garrett Kerr
Anty 101h.02: Anthropology And The Human Experience, David Garrett Kerr
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 101h.80: Anthropology And The Human Experience, David Garrett Kerr
Anty 101h.80: Anthropology And The Human Experience, David Garrett Kerr
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 101h.Bh1: Anthropology And The Human Experience -Hamilton, Jamie L. Ogden
Anty 101h.Bh1: Anthropology And The Human Experience -Hamilton, Jamie L. Ogden
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 104.50: Ancient Migrations, Randall Royce Skelton
Anty 104.50: Ancient Migrations, Randall Royce Skelton
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 133x.B01: Food And Culture, David Garrett Kerr
Anty 133x.B01: Food And Culture, David Garrett Kerr
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 412.01: Osteology, O'Brien Haley
Anty 412.01: Osteology, O'Brien Haley
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Anty 601.02: Research Design & Proposal Preparation, Anna M. Prentiss
Anty 601.02: Research Design & Proposal Preparation, Anna M. Prentiss
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Bch 294.01: Introductory Biochemistry Seminar, Travis S. Hughes
Bch 294.01: Introductory Biochemistry Seminar, Travis S. Hughes
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Bch 380.00: Biochemistry, Kent D. Sugden
Bch 380.00: Biochemistry, Kent D. Sugden
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Bch 482.01: Advanced Biochemistry Ii, J. Stephen Lodmell
Bch 482.01: Advanced Biochemistry Ii, J. Stephen Lodmell
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Bch 547.01: Experimental Molecular, Cellular, & Chemical Biology, Brent J. Ryckman
Bch 547.01: Experimental Molecular, Cellular, & Chemical Biology, Brent J. Ryckman
University of Montana Course Syllabi, 2021-2025
No abstract provided.
Bch 600.01: Cell Organization & Mechanisms, Mark Lindsay Grimes
Bch 600.01: Cell Organization & Mechanisms, Mark Lindsay Grimes
University of Montana Course Syllabi, 2021-2025
No abstract provided.