Digital Commons Network^™

We Are ... Marshall, February 9, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Single-Cell Analysis Of Human Glioma And Immune Cells Identifies S100a4 As An Immunotherapy Target., Nourhan Abdelfattah, Parveen Kumar, Caiyi Wang, Jia-Shiun Leu, William F Flynn, Ruli Gao, David S Baskin, Kumar Pichumani, Omkar B Ijare, Stephanie L Wood, Suzanne Z Powell, David L Haviland, Brittany C Parker Kerrigan, Frederick F Lang, Sujit S Prabhu, Kristin M Huntoon, Wen Jiang, Betty Y S Kim, Joshy George, Kyuson Yun

Faculty Research 2022

A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here, we report an integrated analysis of 201,986 human glioma, immune, and other stromal cells at the single cell level. In doing so, we discover extensive spatial and molecular heterogeneity in immune infiltrates. We identify molecular signatures for nine distinct myeloid cell subtypes, of which five are independent prognostic indicators of glioma patient survival. Furthermore, we identify S100A4 as a regulator of immune suppressive T and myeloid cells in GBM and demonstrate …

Science Café Goes ‘Globetrotting For Violets’ With Harvey Ballard On Feb. 15, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Mark-Recapture Study And Habitat Assessment For The Northern Metalmark Butterfly, Calephelis Borealis (Lepidoptera: Riodinidae), Weston J. Henry, Kristian S. Omland, Henry Frye, Wagner L. David

EEB Articles

Background: The northern metalmark (Calephelis borealis), is an exceedingly local, globally rare butterfly that is declining across the Midwestern and Northeastern USA. The principal stressors driving colony losses include afforestation and invasive plants that crowd out its larval hostplant (Packera ovata) and nectar resources.

Aims/Methods: To better understand its declines and guide restoration efforts, we 1) performed a mark-recapture study in Connecticut to document population trends where we were actively managing vegetation; 2) conducted a range-wide survey for evidence of phylogeographic structure, using cytochrome oxidase (CO1); 3) investigated abundance determinants of its larval foodplant, Packera ovata …

The Current - Volume 32 Issue 19, Nova Southeastern University

Student Newspapers

No abstract provided.

Invisible Trash: Emerging Contaminants In Streams And Rivers, Megan Fork

Sustainability Research & Practice Seminar Presentations

Professor Megan Fork, Biology - Invisible Trash: Emerging Contaminants in Streams and Rivers

Tactical Masters Athletes: Bmi Index Classifications, Marc Keefer, Joe Walsh, Kent Adams, Mike Climstein, Chad Harris, Mark Debeliso

All Faculty Scholarship for the College of Education and Professional Studies

Understanding the nexus between aging, physical activity, and obesity has been a source of ongoing investigation. A considerable amount of research has focused on Masters athletes in this regard, suggesting a beneficial relationship between Masters sport participation and a healthy body mass index (BMI). Some consider Active Duty military personnel as tactical athletes. As such, it is of interest to determine if aging Active Duty military personnel (or Masters Tactical Athletes) might have a similar BMI as other Masters athletes (MA). As such, this investigation examined previously recorded data of Active Duty Enlisted United States Marines (n = 402, male, …

The Lumberjack, February 09, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Differences In Clinical And Functional Outcomes Between Osteochondral Allograft Transplantation And Autologous Chondrocyte Implantation For The Treatment Of Focal Articular Cartilage Defects, John R Matthews, Joseph Brutico, Daniel Abraham, Jeremy Heard, Bradford Tucker, Fotios Tjoumakaris, Kevin Freedman

Rothman Institute Papers

Background: Articular cartilage pathology can result from a spectrum of origins, including trauma, osteochondritis dissecans, avascular necrosis, or degenerative joint disease.

Purpose: To compare the differences in clinical and patient-reported outcomes after autologous chondrocyte implantation (ACI) versus osteochondral allograft transplantation (OCA) in patients with focal articular cartilage defects without underlying bone loss.

Study design: Cohort study; Level of evidence, 3.

Methods: A retrospective review identified patients who underwent ACI or OCA between 2008 and 2016 for isolated grades 3 and 4 articular cartilage defects without underlying bone loss. Outcome measures included the Knee injury and Osteoarthritis Outcome Score for Joint …

Efficacy Of Softener For Enhancing Fatigue And Low-Temperature Performance Of Asphalt Binders With High Rap, Sumon Roy

Student Theses and Dissertations

The use of a higher percentage of reclaimed asphalt pavement (RAP) in asphalt concrete can lead to developing premature failure of asphalt pavements due to fatigue and/or low-temperature cracking. The incorporation of softening agents in asphalt binders can resolve these problems and enhance pavement durability. This study aims to evaluate the effectiveness of waste-based softening agents for enhancing the properties of asphalt mixes with high RAP contents. Waste cooking oil (WCO), and engine bottom oil (EBO) along with a commercial rejuvenator were investigated in this study. Three types of Performance Grade (PG) binders, each collected from two different sources, used …

Functional Maintenance Of Differentiated Embryoid Bodies In Microfluidic Systems: A Platform For Personalized Medicine, Umut A. Gurkan

Faculty Scholarship

Hormone replacement therapies have become important for treating diseases such as premature ovarian failure or menopausal complications. The clinical use of bioidentical hormones might significantly reduce some of the potential risks reportedly associated with the use of synthetic hormones. In the present study, we demonstrate the utility and advantage of a microfluidic chip culture system to enhance the development of personalized, on-demand, treatment modules using embryoid bodies (EBs). Functional EBs cultured on microfluidic chips represent a platform for personalized, patient-specific treatment cassettes that can be cryopreserved until required for treatment. We assessed the viability, differentiation, and functionality of EBs cultured …

Aloin Isoforms (A And B) Selectively Inhibits Proteolytic And Deubiquitinating Activity Of Papain Like Protease (Plpro) Of Sars-Cov-2 In Vitro., Devin S M Lewis, Joanna Ho, Savannah Wills, Anasha Kawall, Avini Sharma, Krishna Chavada, Maximilian C C J C Ebert, Stefania Evoli, Ajay Singh, Srujana Rayalam, Vicky Mody, Shashidharamurthy Taval

PCOM Scholarly Works

The most common host entry point of human adapted coronaviruses (CoV) including SARS-CoV-2 is through the initial colonization in the nostril and mouth region which is responsible for spread of the infection. Most recent studies suggest that the commercially available oral and nasal rinse products are effective in inhibiting the viral replication. However, the anti-viral mechanism of the active ingredients present in the oral rinses have not been studied. In the present study, we have assessed in vitro enzymatic inhibitory activity of active ingredients in the oral mouth rinse products: aloin A and B, chlorhexidine, eucalyptol, hexetidine, menthol, triclosan, methyl …

Tactical Masters Athletes: Bmi Index Classifications, Marc Keefer, Joe Walsh, Kent Adams, Mike Climstein, Chad Harris, Mark Debeliso

Kinesiology Faculty Publications and Presentations

Understanding the nexus between aging, physical activity, and obesity has been a source of ongoing investigation. A considerable amount of research has focused on Masters athletes in this regard, suggesting a beneficial relationship between Masters sport participation and a healthy body mass index (BMI). Some consider Active Duty military personnel as tactical athletes. As such, it is of interest to determine if aging Active Duty military personnel (or Masters Tactical Athletes) might have a similar BMI as other Masters athletes (MA). As such, this investigation examined previously recorded data of Active Duty Enlisted United States Marines ( = 402, male, …

Auxin/Cytokinin Antagonistic Control Of The Shoot/Root Growth Ratio And Its Relevance For Adaptation To Drought And Nutrient Deficiency Stresses, Jasmina Kurepa, Jan A. Smalle

Plant and Soil Sciences Faculty Publications

The hormones auxin and cytokinin regulate numerous aspects of plant development and often act as an antagonistic hormone pair. One of the more striking examples of the auxin/cytokinin antagonism involves regulation of the shoot/root growth ratio in which cytokinin promotes shoot and inhibits root growth, whereas auxin does the opposite. Control of the shoot/root growth ratio is essential for the survival of terrestrial plants because it allows growth adaptations to water and mineral nutrient availability in the soil. Because a decrease in shoot growth combined with an increase in root growth leads to survival under drought stress and nutrient limiting …

Hpg80 (Circulating Progastrin), A Novel Blood-Based Biomarker For Detection Of Poorly Differentiated Neuroendocrine Carcinoma And Well Differentiated Neuroendocrine Tumors, Aman Chauhan, Alexandre Prieur, Jill Kolesar, Susanne Arnold, Léa Payen, Younes Mahi, Berengere Vire, Madison Sands, B. Mark Evers, Dominique Joubert, Lowell Anthony

Markey Cancer Center Faculty Publications

Current blood-based biomarkers for neuroendocrine neoplasms (NENs) lack both sensitivity and specificity. Human circulating progastrin (hPG₈₀) is a novel biomarker that can be easily measured in plasma by ELISA. This study is the first to examine hPG₈₀ in NENs. Plasma hPG₈₀ was quantified from 95 stage IV NEN patients, using DxPG₈₀ technology (ECS Progastrin, Switzerland) and compared with hPG₈₀ concentrations in two cohorts of healthy donor controls aged 50–80 (n = 252) and 18–25 (n = 137). Median hPG₈₀ in NENs patients was 5.54 pM compared to 1.5 pM for the …

Diet Quality And Dietary Inflammatory Index Score Among Women’S Cancer Survivors, Sibylle Kranz, Faten Hasan, Erin Kennedy, Jamie Zoellner, Kristin A. Guertin, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert, Roger Anderson, Wendy Cohn

Faculty Publications

The purpose of this study was to investigate Healthy Eating Index 2015 (HEI-2015) and Energy-Adjusted Dietary Inflammatory Index (E-DIITM) scores in women's cancer survivors and to examine socio-economic (SES) characteristics associated with these two diet indices. In this cross-sectional study, survivors of women's cancers completed a demographic questionnaire and up to three 24-h dietary recalls. HEI-2015 and E-DII scores were calculated from average intakes. One-way ANOVA was used to examine the association of various demographic factors on HEI-2015 and E-DII scores. Pearson Correlation was used to calculate the correlation between the two scores. The average HEI-2015 score was 55.0 +/- …

What Tourists Want, A Sustainable Paradise, Catherine Linnes, Jerome Agrusa, Giulio Ronzoni, Joseph Lema

Hospitality Faculty Research

The increasing complexity of tourism and sustainability offers opportunities and challenges among diverse stakeholder perspectives. The need for sustainable and nature-based approaches exists throughout the growing body of literature from among a number of dimensions and measures. One of the overarching goals of the paper is to examine whether tourists will choose a destination or hotel that is actively working to improve the environment while examining how Hawaii’s tourism is nature-based as well as other measures of sustainability while enjoying a slice of paradise in the Hawaiian Islands. This study explores tourism sustainability concerns in Hawaii, such as the influence …

Spatiotemporal Expression Of Regulatory Kinases Directs The Transition From Mitosis To Cellular Morphogenesis In Drosophila, Shuo Yang, Jennifer Mcadow, Yingqiu Du, Jennifer Trigg, Paul H Taghert, Aaron N Johnson

Open Access Publications

Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is a central question of developmental biology, but the mechanisms controlling mitosis and differentiation are considered to be fundamentally distinct. Here we show the mitotic kinase Polo, which regulates all steps of mitosis in Drosophila, also directs cellular morphogenesis after cell cycle exit. In mitotic cells, the Aurora kinases activate Polo to control a cytoskeletal regulatory module that directs cytokinesis. We show that in the post-mitotic mesoderm, the control of Polo …

Implantable Devices For The Treatment Of Breast Cancer, Mohammad Mohtasim H Pial, Asahi Tomitaka, Nezih Pala, Upal Roy

Health & Biomedical Sciences Faculty Publications

Breast cancer is one of the leading causes of death in the female population worldwide. Standard treatments such as chemotherapy show noticeable results. However, along with killing cancer cells, it causes systemic toxicity and apoptosis of the nearby healthy cells, therefore patients must endure side effects during the treatment process. Implantable drug delivery devices that enhance therapeutic efficacy by allowing localized therapy with programmed or controlled drug release can overcome the shortcomings of conventional treatments. An implantable device can be composed of biopolymer materials, nanocomposite materials, or a combination of both. This review summarizes the recent research and current state-of-the …

Exploring Student Perceptions Of Behavioral, Cognitive, And Emotional Engagement At The Activity Level In General Chemistry, Nicole Naibert, Elizabeth Vaughan, Kylee M. Brevick, Jack Barbera

Chemistry Faculty Publications and Presentations

Although active learning strategies are being incorporated into many higher-education STEM courses, not all students benefit from these activities to the same extent. As these types of activities are designed to engage students in their learning, differences in student engagement may explain some of the differences in learning outcomes. However, before student engagement in active learning activities can be meaningfully measured using a self-report survey, it is important to evaluate if students perceive engagement similarly to the literature definitions on which these measures are based. Therefore, this study sought to explore students’ perceptions of the behavioral, cognitive, and emotional dimensions …

Development And Evaluation Of A Survey To Measure Student Engagement At The Activity Level In General Chemistry, Nicole Naibert, Jack Barbera

Chemistry Faculty Publications and Presentations

Student engagement is an important consideration when incorporating active learning activities into a classroom. To facilitate the large-scale assessment of students’ engagement in activities, a survey measure must first be developed and evaluated. Therefore, the goal of this study was to create a self-report measure of student engagement for use with active learning activities in general chemistry classes. The Activity Engagement Survey (AcES) was modified from an existing survey of engagement of middle and high school science students that contained behavioral, cognitive, emotional, and social engagement items. Multiple rounds of response process interviews and factor analyses were used to modify …

Complexes Of Ghrelin Ghs-R1a, Ghs-R1b, And Dopamine D1 Receptors Localized In The Ventral Tegmental Area As Main Mediators Of The Dopaminergic Effects Of Ghrelin, Gemma Navarro, William Rea, César Quiroz, Estefanía Moreno, Devan Gomez, Cody J. Wenthur, Vicent Casadó, Lorenzo Leggio, Matthew C. Hearing, Sergi Ferré

Biomedical Sciences Faculty Research and Publications

Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a complex modulatory role that depends on its relative expression. D₁ dopamine receptor (D1R) and D5R constitute the two D₁-like receptor subtypes. Previous studies showed that GHS-R1b also facilitates oligomerization of GHS-R1a with D1R, conferring GHS-R1a distinctive pharmacological properties. Those include a switch in the preferred coupling of GHS-R1a from Gq to Gs and the ability of D1R/D5R agonists and antagonists to counteract GHS-R1a signaling. Activation of ghrelin …

Lymphoma With Tuberculous Granulomas, Jyoti Mohan Lal, Anila Rashid

Department of Pathology and Laboratory Medicine

Chronic granulomatous inflammation is a common finding in lymphoproliferative disorders (LPDs), but it is important to exclude coexisting mycobacterium tuberculosis (MTB) especially in patients from areas of high endemicity. This case emphasizes the relevance of performing MTB culture on bone marrow exhibiting LPD and concomitant granulomas

Subanesthetic Ketamine Infusion In Reducing Symptoms Of End-Of-Life Depression: A Case Report, Leanne Groban, Kavita Sharma

Aurora GME

No abstract provided.

Laser Capture Microdissection In The Spatial Analysis Of Epigenetic Modifications In Skin: A Comprehensive Review, Theja Bhamidipati, Mithun Sinha, Chandan K. Sen, Kenhaiya Singh

Student Publications

Each cell in the body contains an intricate regulation for the expression of its relevant DNA. While every cell in a multicellular organism contains identical DNA, each tissue-specific cell expresses a different set of active genes. This organizational property exists in a paradigm that is largely controlled by forces external to the DNA sequence via epigenetic regulation. DNA methylation and chromatin modifications represent some of the classical epigenetic modifications that control gene expression. Complex tissues like skin consist of heterogeneous cell types that are spatially distributed and mixed. Furthermore, each individual skin cell has a unique response to physiological and …

Considering Natural Baselines When Calculating Livestock Impacts Point To A Negligible Role Of Grass-Fed Livestock Systems In Climate Change, P. Manzano, S. R. White

IGC Proceedings (1977-2023)

The use of baselines is common in a variety of academic disciplines, including environmental science, but they are subjected to relativity depending on the geographical or historical reference considered. Such considerations are illustrated by how invasive species are evaluated or what reference baselines are considered in biodiversity assessments.

The measurement of livestock effects on climate change has, however, disregarded the use of baselines. Current methodology is based exclusively on greenhouse gas emissions by individual animals, without putting them in their ecological context. As a consequence, current analyses of livestock impacts put grass-fed ruminant systems in the spotlight, because of their …

Comparative Soil Organic Carbon Dynamics In Tropical And Subtropical Grassland Ecosystems, N. S. Pasricha, P. K. Ghosh

IGC Proceedings (1977-2023)

Grassland ecosystems play significant role in mitigating the climate change by sequestering atmospheric CO₂. One fifth of the total terrestrial C is stored in the root zone of grasslands as soil organic carbon. However, because of lack of proper management, overgrazing, and conversion to crop lands, these grasslands are becoming a source of CO₂ emissions. It has been observed that in Imperata grasslands of Northeast India, a third of total C captured annually is lost though CO₂ emissions. In the absence of intensified grazing and burning, these grasslands exhibit significantly high capacity to store SOC stocks. …

Climate Change Threats To Semi-Arid Transhumance Grazing Systems: Proposals For Adaptation In Cabo Verde, J. F. Castro, S. Tavares, M. Castro

IGC Proceedings (1977-2023)

Global warming has changed the rainfall regime in the Sahelian region, endangering and widespread poverty and chronic famines in Cape Verde, where rural communities' well-being and food security depend on rainy agriculture. Local responses to rainfall new patterns and scarcity have been livestock reduction with significant revenue losses. Together with dry mist occurrences, these environmental constraints demand to define priority actions to adapt and mitigate climate change's direct impacts. According to fifty household inquiries, this work explains the transhumant grazing practices on a semi-arid plateau in Tarrafal (Santiago, Cabo Verde), prospecting adaptation alternatives for sustainability. We related grazing patterns and …

Wild Red Deer Benefit The Conservation Of European Semi-Natural Open Habitats, F. Riesch, Bettina Tonn, Marcus Meißner, Sven Herzog, Niko Balkenhol, J. Isselstein

IGC Proceedings (1977-2023)

Traditional land use practices have shaped European landscapes for millennia. Agricultural intensification and declining popularity of pastoral farming in the past century have resulted in a tremendous loss of extensively used open landscapes and associated biodiversity. Today, conservation management needs to prevent secondary succession of many open habitats. Large or inaccessible target areas unsuitable for conventional conservation measures might benefit from grazing by wild herbivores, which do not require fencing nor regular welfare monitoring. In a military training area in Germany, we studied the quantitative and qualitative effects of wild red deer in two protected open habitat types (lowland hay …

Protecting Mixed-Status Families: Equal Protection Analysis Of The Dual Social Security Number Requirement, Nena Gallegos

University of Chicago Legal Forum

No abstract provided.