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The Kenai Rule In Four Acts: Bear Baiting, Firearms, And Hunting: Comment & Analysis Of Alaska V. Bernhardt, Jon C. Nachtigal, Mike Stocz

Alaska Law Review

The Kenai Rule, enacted by the U.S. Fish and Wildlife Service in 2016, prohibits (a) the hunting of brown bears with bait in the Kenai National Wildlife Refuge, (b) most hunting in the Skilak Wildlife Recreation Area, and (c) the discharge of firearms along the Kenai and Russian Rivers. The Kenai Rule was challenged by the State of Alaska and Safari Club International in Alaska v. Bernhardt. This Comment provides an overview of the case as it was heard in the District Court of Alaska. This discussion includes arguments and counterarguments surrounding the application of four legislative acts: the …

Voltage-Gated Potassium Channel Dependent Mechanisms Of Cardiovascular Adaptation To Chronic Exercise., Sean Raph

Electronic Theses and Dissertations

Exercise increases cardiac workload, escalating the demand for oxygen. The myocardial vasculature responds to the greater demand for oxygen by increasing blood flow to match the needs of the heart during augmented work. Increasing blood flow requires the coronary arteries dilate (a.k.a. vasodilation); this is mediated predominantly by vascular smooth muscle cell relaxation. Vasodilation is driven through inhibition of calcium influx into vascular smooth muscle cells. The prevention of calcium influx is largely mediated by efflux of potassium via potassium channels causing membrane hyperpolarization, which in turn closes voltage-dependent (or gated) calcium channels (VDCC). Changes in vascular smooth muscle cell …

The Graduate Record Examination And Graduate Admissions: Issues In Diversity, Lauren Rankin

Dissertations

Doctoral education is an expensive and difficult endeavor. Program faculty are interested in finding students who will be successful in completing their courses and obtaining employment. The Graduate Record Examination (GRE) is often used to assess a student’s readiness for the rigors of graduate education. A student’s readiness for doctoral education can be assessed through analyzing the predictive validity of the GRE with various outcomes such as grade point average, scholarly output, and time to completion. However, this measure may not predict success for all students with potential bias towards students who are international and linguistically diverse. A total of …

Mindfulness, Self-Compassion, Gratitude, And Burnout: A Structural Equation Model, Allegra Rose Lyon

Dissertations

The present cross-sectional study examined the interrelationships between mindfulness, self-compassion, gratitude, and burnout in a sample of Health Service Psychology doctoral trainees (n=234) using structural equation modeling. Results suggested that mindfulness, self-compassion, and gratitude may each function as important internal resources in mitigating burnout in HSP trainees. A priori models showed poor structural fit and were respecified according to modification indices. The respecified primary model was retained as it showed a good fit (χ2(df) = 347.497(99), p < .001; RMSEA = .074; CFI = .939; TLI = .914; SRMR = .054) and significantly better fit than the respecified alternative model (Δ χ 2(1) = 7.37, p < .01). Mindfulness showed direct positive effects on self-compassion (.643) and gratitude (.346), and direct negative effects on burnout (-.344). Self-compassion (-.271) and gratitude (-.220) each also showed direct negative effects on burnout. Mindfulness also showed significant specific indirect effects on burnout via self-compassion (-.174) and gratitude (-.076). Total indirect effects of mindfulness on burnout were medium negative effects (-.250). Total effect of mindfulness on burnout was a large negative effect (-.595). These results can be used to inform changes at the organizational level for doctoral training programs and can be used at an individual level as tools for empowering trainees to increase internal resources that may help them to engage in more sustainable practice. Theoretical, research, and practice implications for counseling psychologists and limitations are discussed.

Factors Influencing Political Self-Efficacy And Political Astuteness In Undergraduate Nurse Educators, Mark William Longshore

Dissertations

The profession of nursing, 3.9 million strong, continues to lag in taking an active role in the development of health policy. Reasons for that include lack of time, a lack of knowledge, and perceived competence of political action. The factors of knowledge and the related perceived competence, or in the case of this study, self-efficacy, could be improved through education. To that end, it was important to identify if nurse educators had the political astuteness, or knowledge, and self-efficacy. If not, how would nurses learn the necessary skills and gain confidence to be more active politically? The purpose of this …

Person-Oriented And Variable-Oriented Statistical Approaches To Understanding At-Risk, Online High School Students: Predictions Of Academic Outcomes And The Moderating Role Of Protective Factors, Amanda Renee Atwater Jacobs

Dissertations

Many students come to school with risk factors that negatively impact their educational attainment and overall well-being. These risk factors may include but are not limited to abuse, poverty, teen pregnancy, low academic achievement, and learning disabilities. Other types of factors have been shown to provide a protective aspect against risk, and examples include social emotional skills such as grit, flexibility, and social-awareness. There is benefit in individualizing educational experiences for at-risk adolescents based on their specific risks and available protective factors, but knowing how these factors influence and interact with one another to predict academic outcomes is the first …

Mathematical Knowledge For Teaching As Decision-Making For The University Mathematician Developing Coherence In Review Of Discrete Mathematics, Julie Lang

Dissertations

Mathematicians teaching at the university level have a deep understanding and appreciation for the mathematics that they teach. However, they rarely receive much formal training in teaching. Thus, university mathematicians must rely on their mathematical understandings and personally developed ideas of teaching to guide their decision-making. Relatively little research exists on mathematicians’ teaching practices. The purpose of this study was to examine the mathematical knowledge for teaching (MKT) of a university mathematician teaching discrete mathematics and how he leveraged his knowledge to make decisions and develop coherence among mathematical ideas during a semester review. An enactivist perspective examining a mathematician’s …

College Students’ Perceptions Of The Desert Canyons Of The Colorado Plateau, Jeremy Roger Deem

Dissertations

This study investigates eight college students’ perceptions of their experiences during an accredited outdoor education course entitled Technical Canyoneering. The course took place in four separate desert canyons of the Colorado Plateau, two in Arches National Park, and two on nearby Bureau of Land Management public space. Utilizing the data collection process of photo-elicitation, the participants’ time spent in the canyon settings was described in order to gain an understanding of their experiences, with particular attention paid to analyzing what perceptions those students ascribed to those experiences. The intent was threefold. First, the study makes understanding at how college students …

Animal-Assisted Interventions In Supervision: A Collective Case Study, Connie Elizabeth Couch

Dissertations

Animal-assisted interventions (AAIs) have been discussed in recent conceptual literature as having potential for positive implications when applied in supervision (Chandler, 2017; Jackson, 2020; Owenby, 2017; Stewart et al., 2015). However, there was limited empirical foundation or guidance for the integration of two distinct specializations (AAIs and supervision). The purpose of this qualitative collective case study (Stake, 2006) was to explore and understand the experiences of supervisors who have been implementing AAIs within the context of supervision. Specifically, this study addressed the following overarching research question and two sub-questions were addressed: Q1 Why are supervisors integrating AAIs into supervision? Q1a …

Middle School Students’ Perceptions, Experiences, And Behaviors Towards Using A Virtual Reality Application To Build Molecules, Dalal Za'al Ali Alrmuny

Dissertations

To deliver successful integration of virtual reality (VR) technology into chemistry education, it is essential that students have clear and positive perceptions about the purpose and the value of such integration. An important part of establishing a plan for integrating virtual reality technology into chemistry education is to explore the current perceptions, experiences, and behaviors of students towards the use of VR technology to establish an initial baseline of skills and areas in need of development. The purpose of this exploratory mixed methods study was to explore the perceptions, experiences, and behaviors of 62 middle school students in the state …

Estimating The Distribution Of Ratio Of Paired Event Times In Phase Ii Oncology Trials, Li Chen, Mark Burkard, Jianrong Wu, Jill M. Kolesar, Chi Wang

Markey Cancer Center Faculty Publications

With the rapid development of new anti-cancer agents which are cytostatic, new endpoints are needed to better measure treatment efficacy in phase II trials. For this purpose, Von Hoff (1998) proposed the growth modulation index (GMI), that is, the ratio between times to progression or progression-free survival times in two successive treatment lines. An essential task in studies using GMI as an endpoint is to estimate the distribution of GMI. Traditional methods for survival data have been used for estimating the GMI distribution because censoring is common for GMI data. However, we point out that the independent censoring assumption required …

Marriage, Labor Supply And The Dynamics Of The Social Safety Net, Hamish Low, Costas Meghir, Luigi Pistaferri, Alessandra Voena

Cowles Foundation Discussion Papers

The 1996 US welfare reform introduced time limits on welfare receipt. We use quasi-experimental evidence and a lifecycle model of marriage, divorce, program participation, labor supply and savings to understand the impact of time limits on behavior and well-being. Time limits cause women to defer claiming in anticipation of future needs, an effect that depends on the probabilities of marriage and divorce. Time limits cost women 0.5% of life-time consumption, net of revenue savings redistributed by reduced taxation, with some groups affected much more. Expectations over future marital status are important determinants of the value of the social safety net.

The Distribution And Reproductive Success Of The Western Snowy Plover Along The Oregon Coast - 2022, David J. Lauten, Kathleen A. Castelein, Daniel Farrar, Mary Lee, Eleanor P. Gaines

Institute for Natural Resources Publications

We monitored the distribution, abundance and productivity of the federally threatened Western Snowy Plover (Charadrius nivosus nivosus) along the central and south coast of Oregon from 1 April – 15 September 2022. We surveyed and monitored plover activity in a project area that included, from north to south, Sutton Beach, Siltcoos River estuary, the Dunes Overlook, North Tahkenitch Creek, Tenmile Creek, Coos Bay North Spit, Bandon Snowy Plover Management Area, New River Habitat Restoration Area (HRA) and adjacent lands, and Floras Lake. Our objectives for the project area in 2022 were to: 1) estimate the size of the adult Snowy …

A Cloning-Free Recyclable System For Crispr-Cas9 Mediated Mutant And Reversion Construction In Candida Albicans Clinical Isolates, Amanda K. Vogel

Theses and Dissertations (ETD)

Candida albicans is a ubiquitous opportunistic fungal pathogen and one of the most prevalent causes of fungal diseases worldwide. The reference isolate SC5314 is one of the most widely used strains for both experimental and genetic studies, but it is becoming increasingly evident that genetic diversity in clinical isolates plays an important role in antifungal resistance, virulence, and pathogenicity. These recent discoveries highlight the need for genetic tools that are capable of investigating genes in multiple strain backgrounds. Here we build on the SAT1-flipper method and combine it with CRISPR-Cas9 technology to achieve cloning-free homozygous deletion in a single transformation …

Computer-Aided Drug Discovery For Helicobacter Pylori, Nicole Ann Vita

Theses and Dissertations (ETD)

Helicobacter pylori is a high-priority drug-resistant pathogen and is currently the only bacteria considered to be a class I carcinogen and there is a critical need to identify novel chemical matter to treat H. pylori infections. Hp is responsible for greater than 60% of gastric cancer related deaths and 89% of all gastric cancer morbidities. In a previous study, our lab identified novel Hp thienopyrmidine inhibitors that target respiratory complex I, an essential enzyme in respiration. Respiratory complex I is a large asymmetric multidomain and membrane bound enzyme and due to these innate features, it is not practical for biophysical …

Methods Development In Inflammatory Bowel Disease, Andrew B. Steimke

Theses and Dissertations (ETD)

Inflammatory bowel disease (IBD) is a disease that is classified into two subtypes: ulcerative colitis (UC) and Crohn’s disease (CD). Symptoms can range from mild discomfort to requiring surgical intervention and affects approximately 1-in-200 adults in America alone, with global incidence rates increasing. While many treatments exist for IBD, perhaps the main reason for the lack of a cure is that there are many different pathogeneses that all lead to a very similar expression of symptoms. Over 240 IBD loci have been identified to date, yet the causative allele that drives the association has only been identified in ~60 of …

Potential Fitness Trade-Offs Of Elevated Esterase Activity Associated With Insecticide Resistance In The Mosquito Culex Quinquefasciatus, Timothy Schulte

Electronic Theses, Projects, and Dissertations

One of the current major issues in the control of vector-borne disease is resistance to insecticides. Resistance to one or more insecticides has appeared in over 580 different arthropod species. Widespread resistance has led to the field of Insecticide Resistance Management (IRM). The goal of IRM is to develop insecticide-use strategies that prevent or slow down the evolution of resistance. Computer models have shown that more effective IRM strategies rely on the assumption that resistance carries a fitness cost in the absence of insecticide use.

In the mosquito Culex quinquefasciatus resistance to certain organophosphate insecticides is caused by an increased …

Queering Marianne: Witchcraft As A Means Of Sexual Freedom, Amber Guerena

Electronic Theses, Projects, and Dissertations

This thesis is divided in three parts to argue that Emma in the series, Marianne, is homosexual. The first section explains that the witch, Marianne, embodies Emma’s repressed homosexual desires and that her reintroduction to Emma’s life signifies her break away from heteronormative expectations. The second section centers on how religion contributes to Emma’s internal conflict regarding her sexuality. She struggles with choosing which religion to embrace: Christianity, which doesn’t support homosexuality, or witchcraft, which does support homosexuality. The third section explains the strategic choices that the series took to portray Emma’s acceptance of herself and witchcraft. The series …

Spatiotemporal Change Detection Of The Alpine Meadows At Holcomb Valley, San Bernardino Mountain National Forest, Using Gis And Remote Sensing Techniques, Rama Ewing

Electronic Theses, Projects, and Dissertations

Holcomb Valley, with a general elevation between 2200-2257m, is in the Northeast of Big Bear Lake in the San Bernardino Mountains. Holcomb Valley is covered by Alpine meadows, unlike most mountain landscapes, which are rarely found in Mediterranean climates such as California. The cultural-environmental history of the San Bernardino Mountains in the past century speaks of intense anthropogenic activities such as timbering, grazing, gold mining, and extreme climate changes (i.e., drought, fires, floods). A study is conducted to identify and calculate the changes in the Alpine meadows at Holcomb Valley. The climatical data has been acquired to compute and visualize …

Further Validation Of The Realness Scale: Are Celebrity Worshipers Unreal?, Lynn E. Mccutcheon, Lillian Donahue, Joshua L. Williams, Sarah K. Nielson, Scott Peterson, Terry F. Pettijohn Ii

Psychology: Faculty Publications

We administered the Realness Scale (RS), Celebrity Attitude Scale (CAS), and the modified Authentic Living Subscale (ALS) from the Authenticity Scale (AS) to undergraduate students from four American institutions of higher learning. We sought to further validate the RS by showing that it correlated positively with the ALS and negatively with the CAS. We also hypothesized that African Americans would score lower than Whites on the RS. Our results supported the first hypothesis, but we found only weak or non-existent support for the other two hypotheses. Discussion focused on reasons why our latter two hypotheses yielded mostly negative results and …

Coping Strategies And Self-Compassion As Protective Factors In The Infant And Early Childhood Mental Health Workforce, Megan Wolff

Electronic Theses and Dissertations

The mental health field experiences high levels of stress, resulting in a greater risk of poor professional quality of life, likely exacerbated by the additional stress associated with COVID-19. The present study examined the effect COVID-19 stress had on the professional quality of life of the infant and early childhood mental health (IECMH) workforce and whether coping strategies and self-compassion acted as protective factors. Results indicated that higher COVID-19 stress was associated with higher burnout and secondary traumatic stress (STS) and lower compassion satisfaction (CS). The results also showed that the pathway from COVID-19 stress to burnout was moderated by …

Potential Use Of Engineered Nanoparticles In Ocean Fertilization For Large-Scale Atmospheric Carbon Dioxide Removal, Peyman Babakhani, Tanapon Phenrat, Mohammed Baalousha M.Sc, Ph.D., Kullapa Soratana, Caroline L. Peacock, Benjamin S. Twining, Michael F. Hochella Jr.

Faculty Publications

Artificial ocean fertilization (AOF) aims to safely stimulate phytoplankton growth in the ocean and enhance carbon sequestration. AOF carbon sequestration efficiency appears lower than natural ocean fertilization processes due mainly to the low bioavailability of added nutrients, along with low export rates of AOF-produced biomass to the deep ocean. Here we explore the potential application of engineered nanoparticles (ENPs) to overcome these issues. Data from 123 studies show that some ENPs may enhance phytoplankton growth at concentrations below those likely to be toxic in marine ecosystems. ENPs may also increase bloom lifetime, boost phytoplankton aggregation and carbon export, and address …

Fossil Mammals From Hickory Tree Cave, Sullivan County, Tennessee, Alexis Rivera

Electronic Theses and Dissertations

Hickory Tree Cave, also known as Big Spring Cave, is located in the southern Appalachians and is known for fossils that are considered to be Quaternary in age. Fossil mammals were identified and assigned to the lowest taxonomical level possible. Most remains are fragmented or digested and it seems likely that various taphonomic processes are responsible for the resulting assemblage. The site lacks the extreme boreal component of Pleistocene cave faunas in the region (e.g. Baker Bluff Cave), with most reported taxa inhabiting Appalachian deciduous forest environments in North America today. While the presence of tapir (Tapirus sp.) …

Investigating The Pi3k/Akt/Atm Pathway, Telomeric Dna Damage, T Cell Death, And Crispr/Cas9-Mediated Gene Editing During Acute And Chronic Hiv Infection, Sushant Khanal

Electronic Theses and Dissertations

Human Immunodeficiency Virus (HIV) infection initiates major metabolic and cell- survival complications. Anti-retroviral therapy (ART) is the current approach to suppress active HIV replication to a level of undetected viral load, but it is not a curative approach. Newer and sophisticated gene editing technologies could indeed be a potent antiviral therapy to achieve a clinical sterilization/cure of HIV infection. Chronic HIV patients, even under a successful ART regimen, exhibit a low-grade inflammation, immune senescence, premature aging, telomeric DNA attrition, T cell apoptosis, and cellular homeostasis. In this dissertation, we investigated CD4 T cell homeostasis, degree of T cell apoptosis, an …

An Acute Sense Of Place: The Songs Of Norman Blake, Thomas Jutz

Electronic Theses and Dissertations

American flat-picking guitarist, singer and songwriter Norman Blake holds legendary status among guitar players, bluegrass, and folk musicians.

The aim of this research is to analyze the interaction of sense of place in Norman Blake’s songwriting. This research will explore the techniques Blake uses to create that acute sense of place. Elements of literary criticism, cultural geography, ethnomusicology, and sense of place studies, as well as historical background information on Northern Alabama and North Georgia will be employed to show how this particular region of Southeastern Appalachia has informed Blake’s songwriting.

The research questions that I aim to answer are …

A Functional Study Of Topological Dna Problem In Human T Cells During Chronic Viral Infection, Xindi Dang

Electronic Theses and Dissertations

T cells play an important role in adaptive immune system against viral infections, while premature aging and dysfunction of T cells induced by unrepaired DNA damages are always non-negligible snags during the long-term of fighting with chronic viral infections, such as Hepatitis B virus (HBV), Hepatitis C virus (HCV) or Human Immunodeficiency Virus (HIV) infection. In this dissertation, we investigated the role of topological DNA damage in reprogramming telomeric DNA damage responses (DDR), mitochondrial metabolisms, and T cell functions using CD4+ T cells derived from individuals with chronic viral infections or healthy subjects treated with topoisomerase inhibitors. The healthy human …

Importance Of The Microhabitat And Microclimate Conditions In The Northern Gray-Cheeked Salamander (Plethodon Montanus) Across An Elevation Gradient, Trevor Chapman

Electronic Theses and Dissertations

The southern Appalachian Mountains have among the highest salamander diversity in the world, largely due to local speciation in the family Plethodontidae. Plethodontid salamanders (i.e., lungless salamanders) are particularly sensitive to habitat climate conditions due to their reliance on cutaneous respiration, and their immediate environmental conditions (microhabitat) likely influence their dispersion and activity more than the large-scale atmospheric conditions. The Northern Gray-cheeked salamander (Plethodon montanus) is restricted to high elevations in the Appalachian Mountains. Our goal was to investigate the relationship between P. montanus and its microhabitat by examining behavioral preference for climatic conditions, characterizing the microclimate with …

Light And Temperature Entrainment Of Two Circadian-Driven Behaviors In The Flesh Fly Sarcophaga Crassipalpis, Raven Ragsdale

Electronic Theses and Dissertations

Circadian rhythms dictate the timing of both once-in-a-lifetime adult emergence (eclosion) and daily locomotor activity rhythms in the flesh fly S. crassipalpis. Light cycles are considered the primary environmental time cue (zeitgeber), but the life history of S. crassipalpis suggests that temperature cycles (thermocycles) may also play a key role. This work evaluates the efficacy of thermocycling as a zeitgeber in S. crassipalpis. We found that shifting both light and temperature cycles of sufficient amplitude affect the phasing of eclosion and locomotor activity, but result in different patterns. Additional experiments suggest greater thermocycle sensitivity during the late metamorphic …

Nitrogen-Doped And Phosphorus-Doped Epoxy-Sealed Carbon Fiber Ultramicroelectrodes As Electrochemical Sensors For Detection Of Hydrogen Peroxide, Emmanuel Peprah-Yamoah

Electronic Theses and Dissertations

Ultramicroelectrodes (UMEs) are useful as probes for evaluating electroactive species in confined spaces (e.g., inside living cells) and for measuring fast electrochemical reactions. However, UME applications often require modification of the electrode surface to improve selectivity and sensitivity towards target analytes. Previous research in our group demonstrated that a simple soft nitriding method introduces surface nitrogen (N)-containing groups on carbon fiber (CF), leading to improved electroreduction of hydrogen peroxide (H₂O₂) on CF-UMEs. However, sensitivity for H₂O₂ detection using N-CF-UMEs was low compared to that for other modified UMEs. As an alternative to N-CF-UMEs, …

Surrogate Modeling Of Nonlinear Components And Circuits, Byron William Byars

All Theses

Surrogate models are simplified approximations of functions that are described by complex equations. Surrogate modeling of physical systems have been used in various fields such as biology, fluid dynamics, climate modeling, and various other engineering disciplines. This data-driven approach is used to decrease computational cost, decrease computation time, or when the output of a system is diffcult or impossible to measure, by using a \black-box" method to approximate the output given inputs. In regards to circuit analysis, surrogate models can be used to decrease computation time and computational load.

In this thesis, surrogate modeling is used to model various nonlinear …