Digital Commons Network^™

Automating Fda Regulation, Mason Marks

Duke Law Journal

In the twentieth century, the Food and Drug Administration (“FDA”) rose to prominence as a respected scientific agency. By the middle of the century, it transformed the U.S. medical marketplace from an unregulated haven for dangerous products and false claims to a respected exemplar of public health. More recently, the FDA’s objectivity has increasingly been questioned. Critics argue the agency has become overly political and too accommodating to industry while lowering its standards for safety and efficacy. The FDA’s accelerated pathways for product testing and approval are partly to blame. They require lower-quality evidence, such as surrogate endpoints, and shift …

Algorithm V. Algorithm, Cary Coglianese, Alicia Lai

Duke Law Journal

Critics raise alarm bells about governmental use of digital algorithms, charging that they are too complex, inscrutable, and prone to bias. A realistic assessment of digital algorithms, though, must acknowledge that government is already driven by algorithms of arguably greater complexity and potential for abuse: the algorithms implicit in human decision-making. The human brain operates algorithmically through complex neural networks. And when humans make collective decisions, they operate via algorithms too—those reflected in legislative, judicial, and administrative processes. Yet these human algorithms undeniably fail and are far from transparent. On an individual level, human decision-making suffers from memory limitations, fatigue, …

Expression Levels And Genetic Polymorphism Of Scavenger Receptor Class B Type 1 As A Biomarker Of Type 2 Diabetes Mellitus, Mohd Wamique, D. Himanshu, Wahid Ali

Sultan Qaboos University Medical Journal

Objectives: This study aimed to determine whether the expression level and genetic polymorphism scavenger receptor class B type 1 (SCARB1) rs5888 may be used as biological markers in type 2 diabetes mellitus (T2DM). Methods: This case-control study was conducted at King George’s Medical University, Lucknow, India, from September 2018 to December 2019. Blood samples were collected from each individual with T2DM and each healthy individual. Total proteins were determined using western blot analysis. Additionally, restriction fragment length polymorphism analysis was achieved to detect the incidence of genetic polymorphisms. Results: A total of 600 individuals, including 300 individuals with T2DM and …

Current Surgical Indications For Non-Small-Cell Lung Cancer, Nathaniel Deboever, Kyle G Mitchell, Hope A Feldman, Tina Cascone, Boris Sepesi

Faculty, Staff and Student Publications

With recent strides made within the field of thoracic oncology, the management of NSCLC is evolving rapidly. Careful patient selection and timing of multi-modality therapy to permit the optimization of therapeutic benefit must be pursued. While chemotherapy and radiotherapy continue to have a role in the management of lung cancer, surgical therapy remains an essential component of lung cancer treatment in early, locally and regionally advanced, as well as in selected, cases of metastatic disease. Recent and most impactful advances in the treatment of lung cancer relate to the advent of immunotherapy and targeted therapy, molecular profiling, and predictive biomarker …

The Constellation Of Lacan’S Subject Register In Damar Shashangka’S Translation Of Serat Gatholoco, Yostiani Noor Asmi Harini, Hegar Krisna Cambara

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Gatholoco is a figure in Serat Gatholoco, a literary work suspected to be written in the early 19th century. The Gatholoco character is said to have a constellation of desires that presents subversive symptoms, positioning Serat Gatholoco as a controversial text at that time. The aim of this study is to describe the constellation of desires in Serat Gatholoco translation from Damar Shashangka, using the economics perspective of the Lacanian subject. This study used the qualitative interpretive method. The result shows Gatholoco as a sublimation of ideas that become the image-subject in the symbolic register, which is a manifestation of …

Group Psychotherapy For Pain: A Meta-Analysis, Cameron Todd Alldredge

Theses and Dissertations

Chronic pain is common and frequently interferes with people’s regular functioning and reduces quality of life. Though pharmacological approaches are used most frequently to treat pain-related issues, the side effects of these medications often lead to other problems. Group therapy has been used and studied for decades in treating pain though it’s general efficacy for addressing pain is not clear. Objectives: to determine group therapy’s efficacy for patients with pain-related issues and whether the effects are moderated by study, patient, leader, or group characteristics. Method: potential articles were selected from searches completed in major databases based on a set of …

University Philharmonic Orchestra And University Band

Bailey School of Music Concert Programs

Performances by KSU University Band & KSU Philharmonic Orchestra

Deep Learning Model With Adaptive Regularization For Eeg-Based Emotion Recognition Using Temporal And Frequency Features, Alireza Samavat, Ebrahim Khalili, Bentolhoda Ayati, Marzieh Ayati

Computer Science Faculty Publications

Since EEG signal acquisition is non-invasive and portable, it is convenient to be used for different applications. Recognizing emotions based on Brain-Computer Interface (BCI) is an important active BCI paradigm for recognizing the inner state of persons. There are extensive studies about emotion recognition, most of which heavily rely on staged complex handcrafted EEG feature extraction and classifier design. In this paper, we propose a hybrid multi-input deep model with convolution neural networks (CNNs) and bidirectional Long Short-term Memory (Bi-LSTM). CNNs extract time-invariant features from raw EEG data, and Bi-LSTM allows long-range lateral interactions between features. First, we propose a …

Development Of Add-On Materials To Supplement Food Safety Modernization Act Trainings In The Western U.S., Jovana Kovacevic

Journal of Extension

During the 2017 annual meeting of the Western Regional Center to Enhance Food Safety, 52 representatives from 15 western states/territories, regional centers funded through USDA-NIFA Food Safety Outreach Program, federal and state government agencies, and non-governmental organizations prioritized topics for the Food Safety Modernization Act (FSMA) training materials that address region-specific agricultural production and processing systems. This article describes supplemental materials or “add-ons” developed to support FSMA-related food safety trainings. Although the materials were developed for the western region stakeholders, they can be applied or adapted to other regions in or outside the U.S. to enhance food safety trainings.

Effect Of A Tailored Technology-Enhanced Home-Based Exercise Program On Dna Methylation Change Among Cancer Survivors With Multiple Chronic Conditions, Jongmin Park, Nada Lukkahatai

Sigma Foundation for Nursing Research Grant Reports

This study aims to (1) examine the pre-and-post tailored home-based exercise (iHBE) program epigenetic changes (2) examine the associations of changes in DNA methylation age with symptoms (pain, fatigue, cognitive function) and resilience at completion (12-week) compared to baseline data collected from cancer survivors living with multiple chronic conditions.

Eye State Identification Utilizing Eeg Signals: A Combined Method Using Self-Organizing Map And Deep Belief Network, Neda Ahmadi, Mehrbakhsh Nilashi, Behrouz Minaei-Bidgoli, Murtaza Farooque, Sarminah Samad, Nojood O. Aljehane, Waleed Abdu Zogaan, Hossein Ahmadi

School of Nursing and Midwifery

Measuring brain activity through Electroencephalogram (EEG) analysis for eye state prediction has attracted attention from machine learning researchers. There have been many methods for EEG analysis using supervised and unsupervised machine learning techniques. The tradeoff between the accuracy and computation time of these methods in performing the analysis is an important issue that is rarely investigated in the previous research. This paper accordingly proposes a new method for EEG signal analysis through Self-Organizing Map (SOM) clustering and Deep Belief Network (DBN) approaches to efficiently improve the computation and accuracy of the previous methods. The method is developed using SOM clustering …

Unpacking Efl Teachers’ Tpack Thru The Distance Education, Sofia Imania, Mirjam Anugerahwati, Sintha Tresnadewi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The growth of distance education provides an accessibility of teaching-and-learning-process involving the use of ICT. Hence, teachers’ competencies regarding the integration of ICT also one of the key success of teaching. Through TPACK, this study aims at investigating EFL teachers’ skills on technology integration and their preferable ICT based learning system amidst distance education. Moreover, this study also intends to analyze whether EFL teachers’ TPACK are significantly different in terms of teaching categories and gender. This survey study implicated 139 in-service EFL teacher in the city of Malang, East Java, Indonesia. The data were collected through questionnaire and analyzed by …

Plant Protein-Based Food Packaging Films; Recent Advances In Fabrication, Characterization, And Applications, Milad Hadidi, Shima Jafarzadeh, Mehrdad Forough, Farhad Garavand, Saeid Alizadeh, Ali Salehabadi, Amin Mousavi Khaneghah, Seid Mahdi Jafari

Research outputs 2022 to 2026

Background: Plant-based proteins as an alternative to synthetic polymers have attracted the interest of the global packaging industry in the last decade due to their biodegradability, sustainability, environmental, and beneficial health claims.

Scope and approach: This review covers the recent developments in biodegradable packaging such as edible films/coatings and innovative packaging materials based on plant protein sources. The importance, sources, and techno-functional properties of plant-derived proteins for food packaging are discussed. The impact of different additives on the functionality of plant protein-based biodegradable materials is also investigated. In addition, plant protein-based packaging characteristics and their application in food are also …

Dietary Nitrate Supplementation Does Not Alter Exercise Efficiency At High Altitude – Further Results From The Xtreme Alps Study, Philip J. Hennis, Andrew F. Cumpstey, Alasdair F. O’Doherty, Bernadette O. Fernandez, Edward T. Gilbert-Kawai, Kay Mitchell, Helen Moyses, Alexandra Cobb, Paula Meale, Helmut Pöhnl, Monty G. Mythen, Michael P.W. Grocott, Denny Z.H. Levett, Daniel S. Martin, Martin Feelisch

Peninsula Medical School

IntroductionNitrate supplementation in the form of beetroot juice (BRJ) ingestion has been shown to improve exercise tolerance during acute hypoxia, but its effect on exercise physiology remains unstudied during sustained terrestrial high altitude exposure. We hypothesized that performing exercise at high altitude would lower circulating nitrate and nitrite levels and that BRJ ingestion would reverse this phenomenon while concomitantly improving key determinants of aerobic exercise performance.MethodsTwenty seven healthy volunteers (21 male) underwent a series of exercise tests at sea level (SL, London, 75 m) and again after 5–8 days at high altitude (HA, Capanna Regina Margherita or “Margherita Hut,” 4,559 …

Blood Biomarkers For Cognitive Decline And Clinical Progression In A Mexican American Cohort, Mitzi M. Gonzales, Chen-Pin Wang, Meghan I. Short, Danielle M. Parent, Tiffany Kautz, Daniel Maccarthy, Claudia L. Satizabal, David Andrés González, Donald R. Royal, Gladys E. Maestre

School of Medicine Publications

Introduction: The clinical translation of biofluid markers for dementia requires validation in diverse cohorts. The study goal was to evaluate if blood biomarkers reflecting diverse pathophysiological processes predict disease progression in Mexican American adults.

Methods: Mexican American adults (n = 745), 50 years of age and older, completed annual assessments over a mean of 4 years. Serum collected at baseline was assayed for total tau, neurofilament light (NFL), ubiquitin carboxyl‐terminal hydrolase LI, glial fibrillary acidic protein (GFAP), soluble cluster of differentiation 14 (sCD14), and chitinase‐3‐like protein 1 (YKL‐40).

Results: Higher GFAP and NFL were associated with global …

What And Who Has Determined Adoption? A Study On Improved Forage Technologies In Colombia From An Agricultural Innovation System (Ais) Perspective, K. Enciso, N. Triana, M. Díaz, S. Burkart

IGC Proceedings (1977-2023)

The complex process behind the adoption of improved forages in Colombia remains largely unexplored. Despite governmental and scientific efforts to promote and disseminate the implementation of improved forages for the sake of sustainable livestock production, local livestock producers continue to extensively use native species and adoption rates of more efficient forages remain low. This study explores the dynamics behind the development and diffusion of improved forage technologies in Colombia, from the 1960's to the present through an Agricultural Innovation Systems (AIS) perspective. Here we map the agents involved, classify the roles they exerted over time and reconstruct the historical context …

From Theory To Practice: What Should We Have In Mind When Building Effective And Sustainable Payments For Ecosystem Services (Pes) Schemes For Silvo-Pastoral Systems? Evidence From Colombia, M. Díaz, K. Enciso, N. Triana, S. Burkart

IGC Proceedings (1977-2023)

In most Latin American countries, payment for ecosystem services (PES) can be a useful strategy for restoration and conservation of the environment, increasing productivity and promoting sustainable development in rural areas. Despite these plausible benefits, PES implementation can be challenging due to the contextual framework in which it takes place (e.g. institutional weakness in the implementation and monitoring stages, limited connectivity among stakeholders, low adoption levels of agricultural technology). This study aims at evaluating PES schemes for silvo-pastoral systems in Colombia by considering six dimensions based on an extensive literature review: policy and governance; social context; environmental context; risks and …

Smallholder Dairy Farmers In The Peruvian Andes Fulfilling The Role Of Extension Agents, C. S. Pinares-Patino, J. Manhire, R. Garcia Ticllacuri, J. L. Bernal Madrid, V. M. Velez Marroquin

IGC Proceedings (1977-2023)

Dairy farming in the Peruvian Andes is mostly undertaken by smallholder farmers (4-6 cows/family) and of relatively recent development. In fact, over the last 2 decades dairy farming at high altitudes (3,500‒4200 masl) has grown rapidly, replacing the camelids and sheep farming that once predominated. Dairying growth has been catalysed by subsides from state and private organizations. It promotes high input systems based on feedlot technology. Compared to sheep and camelids farming, dairying at the Andes does not have yet an inherent local/indigenous knowledge associated to it. High altitude Andean ecosystems pose many constraints for dairy farming (hypoxia and high …

The Rhetoric Of Detachment And Collective Identity Politics In Out Of Place By Edward Said: Transcending Modernist Aesthetics, Ahmad Qabaha

An-Najah University Journal for Research - B (Humanities)

This study aims to trace the construction of affiliations and modes of belonging in Out of Place (1999) by Edward Said, in conjunction with his other works, that transgress real connections and present realities, and challenge the coherence of conventional notions of identity and detachment. It argues that Said reassesses his attachments and collective identity politics, not by rejecting his filiations but by finding a way to reconstruct or retrieve them. By thinking of Said and Darwish contrapuntally, this paper shows that Said works through these detachments, and moves between multiple identities to reconstruct a ‘filiative’ personal narrative which in …

Male Breast Cancer: The Three Decades' Experience Of A Tertiary Care Hospital In A Lower-Middle Income Country, Sana Zeeshan, Muhammad Tayyab, Fatima Shaukat, Muhammad Usman Tariq, Nargis Khan, Lubna Vohra

Section of General Surgery

Introduction Male breast cancer is uncommon and managed on the guidelines of female breast cancer due to tumor rarity. We sought to identify the incidence, clinicopathological features, and survival of all male breast cancer patients managed in our hospital. Methods A retrospective cross-sectional study was conducted at Aga Khan University Hospital (AKUH), Karachi, Pakistan, from January 1986 to December 2018. Demographic data, treatment records, and follow-up data of all male breast cancer patients who were treated at AKUH was reviewed. Results Thirty-eight out of 42 patients who presented over a period of 32 years were included. The mean age was …

Strategies To Promote Responsive Bottle-Feeding In Wic Predict Less Frequent Use Of Food To Soothe And Healthier Weight Status For Infants With Negative Temperaments, Alison K. Ventura, Shannon E. Whaley

Kinesiology and Public Health

Background: Infants with greater temperamental negative affectivity are at higher risk for overfeeding and excess weight gain.

Objective: To examine whether strategies to promote responsive bottle-feeding within WIC promoted healthier maternal feeding practices and infant weight status among infants with greater negative affectivity.

Methods: Secondary analysis of data from a matched-pair cluster randomized trial. Policy, systems and environmental change (PSE) strategies to promote responsive bottle-feeding were implemented at three WIC clinics; these clinics were compared with three matched control clinics. Linear mixed models tested whether infant negative affectivity interacted with PSE strategies to predict feeding and weight outcomes when infants …

Kathy Palmer, Oral History Interview, 2022, Matt Jones

Oral Histories

In 2021, Eastern Michigan University Archives lecturer Matt Jones began documenting the story of Ypsilanti’s Human Rights Ordinance #1279 in an effort to explore the ways in which local queer activism has evolved multi-generationally in Ypsilanti. What began as a refusal of service by a local print shop to a small EMU student group quickly turned into a years-long battle over who was deserving of basic human rights. To the LGBTQ activists and community members documented here, they had always been present in the community: working, paying taxes, painting their houses, mowing their lawns, attending council meetings, and even serving …

Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated With Atorvastatin Intake By Targeting Cerebral Mirna155 And Nlrp3: In Vivo, And In Silico Study, Doaa I. Mohamed, Dalia Alaa El-Din Aly El-Waseef, Enas S. Nabih, Omnyah A. El-Kharashi, Hanaa F. Abd El-Kareem, Hebatallah H. Abo Nahas, Basel A. Abdel-Wahab, Yosra A. Helmy, Samar Zuhair Alshawwa, Essa M. Saied

Veterinary Science Faculty Publications

Alcoholism is one of the most common diseases that can lead to the development of several chronic diseases including steatosis, and cognitive dysfunction. Statins are lipid-lowering drugs that are commonly prescribed for patients with fatty liver diseases; however, the exact effect of statins on cognitive function is still not fully understood. In the present study, we have investigated the molecular and microscopic basis of cognitive impairment induced by alcohol and/or Atorvastatin (ATOR) administration to male Wistar albino rats and explored the possible protective effect of acetylsalicylic acid (ASA). The biochemical analysis indicated that either alcohol or ATOR or together in …

Challenges In Gluten Analysis: A Comparison Of Four Commercial Sandwich Elisa Kits, Plaimein Amnuaycheewa, Lynn Niemann, Richard E. Goodman, Joseph L. Baumert, Steve L. Taylor

Department of Food Science and Technology: Faculty Publications

Gluten is composed of prolamin and glutelin proteins from several related grains. Because these proteins are not present in identical ratios in the various grains and because they have some differences in sequence, the ability to accurately quantify the overall amount of gluten in various food matrices to support gluten-free labeling is difficult. Four sandwich ELISAs (the R-Biopharm AG R5 RIDASCREEN®, the Neogen Veratox® R5, the Romer Labs AgraQuant® G12, and the Morinaga Wheat kits) were evaluated for their performance to quantify gluten concentrations in various foods and ingredients. The Morinaga and AgraQuant® G12 tests yielded results comparable to the …

Decellularized Articular Cartilage Microgels As Microcarriers For Expansion Of Mesenchymal Stem Cells, Esmaiel Jabbari, Azadeh Sepahvandi

Faculty Publications

Conventional microcarriers used for expansion of human mesenchymal stem cells (hMSCs) require detachment and separation of the cells from the carrier prior to use in clinical applications for regeneration of articular cartilage, and the carrier can cause undesirable phenotypic changes in the expanded cells. This work describes a novel approach to expand hMSCs on biomimetic carriers based on adult or fetal decellularized bovine articular cartilage that supports tissue regeneration without the need to detach the expanded cells from the carrier. In this approach, the fetal or adult bovine articular cartilage was minced, decellularized, freeze-dried, ground, and sieved to produce articular …

Recombination Mediator Proteins: Misnomers That Are Key To Understanding The Genomic Instabilities In Cancer, Justin Courcelle, Travis K. Worley, Charmain Courcelle

Biology Faculty Publications and Presentations

Recombination mediator proteins have come into focus as promising targets for cancer therapy, with synthetic lethal approaches now clinically validated by the efficacy of PARP inhibitors in treating BRCA2 cancers and RECQ inhibitors in treating cancers with microsatellite instabilities. Thus, understanding the cellular role of recombination mediators is critically important, both to improve current therapies and develop new ones that target these pathways. Our mechanistic understanding of BRCA2 and RECQ began in . Here, we review the cellular roles of RecF and RecQ, often considered functional homologs of these proteins in bacteria. Although these proteins were originally isolated as genes …

Decellularized Articular Cartilage Microgels As Microcarriers For Expansion Of Mesenchymal Stem Cells, Esmaiel Jabbari, Azadeh Sepahvandi

Faculty Publications

Conventional microcarriers used for expansion of human mesenchymal stem cells (hMSCs) require detachment and separation of the cells from the carrier prior to use in clinical applications for regeneration of articular cartilage, and the carrier can cause undesirable phenotypic changes in the expanded cells. This work describes a novel approach to expand hMSCs on biomimetic carriers based on adult or fetal decellularized bovine articular cartilage that supports tissue regeneration without the need to detach the expanded cells from the carrier. In this approach, the fetal or adult bovine articular cartilage was minced, decellularized, freeze-dried, ground, and sieved to produce articular …

Pastoralists’ Perception Of Poverty: A Case Of The Somali And Turkana Of Northern Kenya, W. P. Watete, Kogi-Makau

IGC Proceedings (1977-2023)

Poverty is a complex phenomenon, without a single definition or standard methods of reducing it. Income based methods of assessing poverty have been shown to have limitations that undermine their application in measuring and attacking poverty among pastoral households. Stages of progress method of poverty assessment was used to assess poverty among pastoral households in Turkana and Mandera Counties of Northern Kenya. Three hundred and three hundred and fifty-four households in Mandera and Turkana Counties respectively were sampled across three different livelihood zones: pastoral, agro-pastoral and off-farm. Accumulation of livestock was regarded as a key indicator of wealth among pastoral …

Pastoralist Conservation: Local Ecological Knowledge And Collective Action For Grassland Conservation In Sierra De Segura (Spain), P. Sanosa-Cols, F. Ravera, F. Dominguez, M. Ventura

IGC Proceedings (1977-2023)

Even if Pastoralism is not practised anymore by a majority of families in the Sierra de Segura (south-eastern Andalusia, Spain), it is still considered a paradigmatic way of life and management of its highlands and a key cultural heritage deeply rooted in local identity. In this article we explore two pastoral communities of this region, Santiago and Pontones, with their body of situated knowledge of the territory and natural resources, which helps pastoralists to organize their livelihoods, while requiring collective organization to manage access to grasslands. Through an ethnographic research based on participant observation and in-depth interviews, we explore the …

Intensification Of Pastoralism As A Driver Of Degradation In The Algerian Steppe, S. Bencherif, P. Manzano

IGC Proceedings (1977-2023)

Land degradation linked to pastoralism use has been a worldwide concern for decades. A biological approach has often been use to understand such phenomena, usually disregarding economic and social factors. Radical transformations of pastoralism at the Algerian steppe constitute a good case study to provide an integrated understanding and to better orient development in other pastoralist areas across the world. Different actions by the public sector since the 1960s, as well as the land legislation adopted and the strong agricultural subventions during 2000-2010, have favored a massive conversion of land and resource management. This translates into conversion of many pastures …