Digital Commons Network^™

The Global Virome In One Network (Virion): An Atlas Of Vertebrate-Virus Associations, Colin J. Carlson, Rory J. Gibb, Gregory F. Albery, Liam Brierley, Ryan P. Connor, Tad Dallas, Evan A. Eskew, Anna C. Fagre, Maxwell J. Farrell, Hannah K. Frank, Renata L. Muylaert, Timothée Poisot, Angela L. Rasmussen, Sadie J. Ryan, Stephanie N. Seifert

Faculty Publications

Data that catalogue viral diversity on Earth have been fragmented across sources, disciplines, formats, and various degrees of open sharing, posing challenges for research on macroecology, evolution, and public health. Here, we solve this problem by establishing a dynamically maintained database of vertebrate-virus associations, called The Global Virome in One Network (VIRION). The VIRION database has been assembled through both reconciliation of static data sets and integration of dynamically updated databases. These data sources are all harmonized against one taxonomic backbone, including metadata on host and virus taxonomic validity and higher classification; additional metadata on sampling methodology and evidence strength …

Firearm Injuries Among Children Due To The Kivu Conflict From 2017 To 2020: A Hospital-Based Retrospective Descriptive Cohort Study, Romeo Bujiriri Murhega, Paul Munguakonkwa Budema, Tshibambe Nathanael Tshimbombu, Georges Kuyigwa Toha, Fabrice Gulimwentuga Cikomola, Paterne Safari Mudekereza, Léon Emmanuel Mubenga, Ghislain Maheshe Balemba, Darck Cubaka Badesire, Ahmed Negida, Ulrick Sidney Kanmounye

Dartmouth Scholarship

Introduction: Firearm-related injuries are deadly but avoidable. The case of Kivu, a region in the Eastern Democratic Republic of Congo (DRC), is alarming. Decades of unresolved regional conflicts birthed armed groups that have massacred inhabitants and injured several children. This regional instability has also created barriers to seeking and obtaining timely care, decreasing the survival rate. This region's lack of data on paediatric fatal and nonfatal firearm injuries (F&NFFIs) needs studying. Thus, we aim to determine the prevalence and evaluate the outcomes of paediatric F&NFFIs in Kivu. Methods: We included all F&NFFI paediatric patients (≤18 years), admitted at our institution …

Pharmacological Antagonism Of Ep2 Receptor Does Not Modify Basal Cardiovascular And Respiratory Function, Blood Cell Counts, And Bone Morphology In Animal Models., Varun Rawat, Avijit Banik, Radhika Amaradhi, Asheebo Rojas, Shashidharamurthy Taval, Tamas Nagy, Raymond Dingledine, Thota Ganesh

PCOM Scholarly Works

The EP2 receptor has emerged as a therapeutic target with exacerbating role in disease pathology for a variety of peripheral and central nervous system disorders. We and others have recently demonstrated beneficial effects of EP2 antagonists in preclinical models of neuroinflammation and peripheral inflammation. However, it was earlier reported that mice with global EP2 knockout (KO) display adverse phenotypes on fertility and blood pressure. Other studies indicated that EP2 activation with an agonist has a beneficial effect of healing fractured bone in animal models. These results impeded the development of EP2 antagonists, and EP2 antagonism as therapeutic strategy. To determine …

Race And Washington’S Criminal Justice System: 2021 Report To The Washington Supreme Court, Task Force 2.0

Washington Law Review

RACE & WASHINGTON’S CRIMINAL JUSTICE SYSTEM:

EDITOR’S NOTE

As Editors-in-Chief of the Washington Law Review, Gonzaga Law Review, and Seattle University Law Review, we represent the flagship legal academic publications of each law school in Washington State. Our publications last joined together to publish the findings of the first Task Force on Race and the Criminal Justice System in 2011/12. A decade later, we are honored to join once again to present the findings of Task Force 2.0. Law journals have enabled generations of legal professionals to introduce, vet, and distribute new ideas, critiques of existing legal structures, and reflections …

Integration Of Long-Read Whole Genome Sequencing In Graduate Curriculum Of Diagnostic Genetics And Genomics, Xiaojun Liu Phd, Med, Yasmine M. Hoballah Ms, Peter Hu Phd, Awdhesh Kalia Phd

Education Week Poster Showcase 2022

No abstract provided.

The Global Practice Of Systematic Enforced Disappearances Of Children In International Law: Strategies For Preventing Future Occurrences And Solving Past Cases, Jeremy J. Sarkin, Elisenda Calvet Martinez

Catholic University Law Review

The aim of this article is to first investigate and understand the widespread and systematic practice of enforced disappearances against children around the world, with a key purpose being to show that it is a regular occurrence. The article reviews the systematic disappearances of children in their historical context, beginning from the Second World War. A variety of country examples –some historical and some contemporary –are discussed to indicate the widespread nature of the practice. The variety of cases is used to understand why states participate in such practices and why children specifically are targeted as victims of enforced disappearances. …

Under-Enforcement Of Federal Animal Protection Laws: Agencies Abdicating Enforcement Authority, And An Outlier Eleventh Circuit ‘Serious Harm’ Rule, Rebekah Green

Catholic University Law Review

Congress enacted the Endangered Species Act, Animal Welfare Act, and the Marine Mammal Protection Act to protect and preserve endangered and threatened fish and wildlife, animals, and marine mammals. The United States Department of Agriculture (“USDA”) is the primary administrative agency in charge of regulating zoos, wildlife centers, and aquariums, yet fails to consistently enforce the Animal Welfare Act, which this Comment reviews. This means that private animal advocacy agencies are left suing zoos, wildlife centers, and aquariums under the “taking” clause of the Endangered Species Act in order to ensure animal safety and care. While most circuits agree upon …

Photonic Integrated Circuit-Assisted Optical Time-Domainreflectometer System, Mehmet Cengi̇z Onbaşli

Turkish Journal of Electrical Engineering and Computer Sciences

Optical time-domain reflectometers (OTDR) are photonic systems that consist of an interrogator, a receiver and a fiber optical cable and have applications in telecommunications, security, environmental monitoring, distributed temperature and strain sensing. Since OTDR systems are bulk optical setups that consume multiple Watts of power, have large mass and volume footprint and are vulnerable to thermal drift, deployment of OTDR systems in the field is expensive, complicated and may not necessarily yield accurate sensing results. Thus, a compact, low-power, inexpensive and thermal drift-free OTDR system needs to be developed for improving the accuracy and the viability of OTDR in the …

Design And Manufacture Of Electromagnetic Absorber Composed Of Boricacid-Incorporated Wastepaper Composites, Ali̇ İhsan Kaya, Ahmet Çi̇fci̇, Fi̇li̇z Kirdioğullari, Mesud Kahri̇man, Osman Çerezci̇

Turkish Journal of Electrical Engineering and Computer Sciences

With the effect of technological advances, the use of electrical and electronic devices has increased dramatically in recent years. Wireless technologies and related applications are mostly preferred for the communication of these devices with each other. Thus, people are easily exposed to electromagnetic waves in daily life. The extensive global use of these devices raises the question of their possible biological effects on human health. Also, electromagnetic waves influence the functioning of a nearby device. In this study, an electromagnetic absorber based on boric acid (5, 10, 20, and 30 wt%) added wastepaper was developed. Copper (Cu) and aluminum (Al) …

Hope Dies Last: The Progressive Potential And Regressive Reality Of The Antibalkanization Approach To Racial Equality, David Simson

William & Mary Bill of Rights Journal

This Article relies on Critical Race Theory concepts and social science research to make an important and timely contribution to a debate in law and public policy that is both long-standing and of immense current importance: What is the relationship between social cohesion on the one hand, and racial equality progress on the other?

[...]

Over the last four decades, the Supreme Court’s equal protection jurisprudence on governmental race-consciousness has answered with an “antibalkanization approach” which prioritizes social cohesion. Indeed, this approach views social cohesion as a prerequisite for racial equality progress. It considers racial hostility and resentment among White …

The H3.3 Chaperone Hira Complex Orchestrates Oocyte Developmental Competence, Rowena Smith, Andrej Susor, Hao Ming, Janet Tait, Marco Conti, Zongliang Jiang, Chih Jen Lin

Faculty Publications

Successful reproduction requires an oocyte competent to sustain early embryo development. By the end of oogenesis, the oocyte has entered a transcriptionally silenced state, the mechanisms and significance of which remain poorly understood. Histone H3.3, a histone H3 variant, has unique cell cycle-independent functions in chromatin structure and gene expression. Here, we have characterised the H3.3 chaperone Hira/Cabin1/Ubn1 complex, showing that loss of function of any of these subunits causes early embryogenesis failure in mouse. Transcriptome and nascent RNA analyses revealed that transcription is aberrantly silenced in mutant oocytes. Histone marks, including H3K4me3 and H3K9me3, are reduced and chromatin accessibility …

The Potential Of Dietary Bioactive Compounds Against Sars-Cov-2 And Covid-19-Induced Endothelial Dysfunction, Jack N. Losso

Faculty Publications

COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with dysfunctional endothelium. Genetics and environmental factors (epigenetics) are major risk factors for endothelial dysfunction. Individuals with metabolic syndrome are at increased risk for severe SARS-CoV-2 infection and poor COVID-19 outcomes and higher risk of mortality. Old age is a non-modifiable risk factor. All other risk factors are modifiable. This review also identifies dietary risk factors for endothelial dysfunction. Potential dietary …

Long-Range Interactions For Hydrogen Atoms In Excited D States, Chandra M. Adhikari, Ulrich D. Jentschura

College of Health, Science, and Technology

Pressure shifts inside an atomic beam are among the more theoretically challenging effects in high-precision measurements of atomic transitions. A crucial element in their theoretical analysis is the understanding of long-range interatomic interactions inside the beam. For excited reference states, the presence of quasi-degenerate states leads to additional challenges, due to the necessity to diagonalize large matrices in the quasi-degenerate hyperfine manifolds. Here, we focus on the interactions of hydrogen atoms in reference states composed of an excited nD state (atom A), and in the metastable 2S state (atom B). We devote special attention to the cases n = 3 …

“It Is Not Out There, And It’S In Here”: The Challengingand Duality Perspective Of Teaching Gender In Journalism And Media Studies In Private Universities, Fitria Angeliqa, Lestari Nurhajati

JURNAL KOMUNIKASI INDONESIA

This study aimed to determine challenges of teaching gender in journalism and media studies courses on various campuses in Jakarta, Indonesia. The ‘otherness’ is still ghosting the lecturer, where the duality is a must to create comprehension on gender topics. It is essential because teaching the gender issue in communication study programs in Indonesia does not reflect a lot on women’s experiences. The theory of gender pedagogy is the basis of this study. Meanwhile, the duality perspective serves as its framework. Gender pedagogy is not just a tool, strategy, or practical technique for understanding gender teaching in education. Teaching gender …

The Ideology Of Racism In Contemporary Hollywoodfilms On Netflix: A Case Study On“All The Boys I’Ve Loved Before” Movie, Rizki Briandana, Rustono Farady Marta, Rohana Mijan, Eka Perwitasari Fauzi

JURNAL KOMUNIKASI INDONESIA

This study aims to analyse the ideology of racism in Hollywood films shown on Netflix. To All the Boys I’ve Loved Before is a film based on a New York Times Best Seller novel. Initially, this film had some drawbacks because almost all production houses refused to keep an Asian face as the main character in accordance with the novel. The concept of ideology in the film refers to the concept proposed by John Storey. That ideology is an ideal form of image which aims to attract attention through methods, such as those used in texts, including films as mass …

A Communication Strategy Of Support Providers In Providing Supports For Sexual Violence Victims, Desideria Lumongga Dwihadiah, Alya Hadijah Stephanie

JURNAL KOMUNIKASI INDONESIA

Sexual violence is a big problem in society, because the negative impact on the victim causes prolonged suffering. Assistance for victims is carried out at the individual, group and institutional levels, both formal and informal. They act as support providers for sexual violence victims. Support providers often experience difficulties because victims find it difficult to open up due to the trauma they have experienced. A strategy to communicate is necessary, so the providers can well provide supports and assistances to victims. This study wanted to explore communication strategies used by support providers in dealing with and helping sexual violence victims. …

Incomplete Consumption Of Successfully Caught Prey By A Short-Tailed Hawk (Buteo Brachyurus), Kendalynn A. Morris, Andrew M. Durso

Florida Field Naturalist

No abstract provided.

Efficacy Of Losartan In Hospitalized Patients With Covid-19-Induced Lung Injury: A Randomized Clinical Trial, Michael A. Puskarich, Nicholas E. Ingraham, Lisa H. Merck, Brian E. Driver, David A. Wacker, Lauren Page Black, Alan E. Jones, Courtney V. Fletcher, Andrew M. South, Thomas A. Murray, Christopher A. Lewandowski, Joseph Farhat, Justin L. Benoit, Michelle H. Biros, Kartik Cherabuddi, Jeffrey G. Chipman, Timothy W. Schacker, Faheem W. Guirgis, Helen T. Voelker, Joseph S. Koopmeiners, Christopher J. Tignanelli

Emergency Medicine Articles

Importance: SARS-CoV-2 viral entry may disrupt angiotensin II (AII) homeostasis, contributing to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates lung injury in preclinical models, although data in humans with COVID-19 remain mixed.

Objective: To test the efficacy of losartan to reduce lung injury in hospitalized patients with COVID-19.

Design, Setting, and Participants: This blinded, placebo-controlled randomized clinical trial was conducted in 13 hospitals in the United States from April 2020 to February 2021. Hospitalized patients with COVID-19 and a respiratory sequential organ failure assessment score of at least 1 and not already using a renin-angiotensin-aldosterone system (RAAS) …

"Because Of Sex": Title Vii's Failures Leave Legal Sex Workers Unprotected, Lauren Boone

North Carolina Law Review

No abstract provided.

Spatial And Temporal Analysis Of Big Dataset On Pm2.5 Air Pollution In Beijing, China, 2014 To 2018, Hutong Fan

Great Lakes Center Masters Theses

Air particulate matter (PM_2.5) pollution is a critical environment problem worldwide and also in Beijing, China. We gathered five-year PM_2.5 contaminate concentrations from 2014 to 2018, from the Beijing Municipal Environmental Monitoring Center and China Air Quality Real-time Distribution Platform. This is a big dataset, and we collected with crawler technology from Python programming. After examining the quality of the recorded data, we determined to conduct the temporal and spatial analysis using 27 observation stations located in both urban and suburb area in the municipality of Beijing. The big dataset of five-year hourly PM_2.5 concentrations was …

Endemism, Projected Climate Change, And Identifying Species Of Critical Concern In The Scrub Mint Clade (Lamiaceae), Andre A. Naranjo, Anthony E. Melton, Douglas E. Soltis, Pamela S. Soltis

Biology Faculty Publications and Presentations

Recent studies have revealed that narrow endemics, particularly those native to the North American Coastal Plain, are experiencing range contractions due to human development and anthropogenic-driven climate warming. We model how the projected distributions of a group of scrub-adapted plant species with similar evolutionary histories change in response to warming climates. The Scrub Mint clade (Lamiaceae) (SMC), which comprises 24 species in Dicerandra, Conradina, Stachydeoma, Piloblephis, and Clinopodium, including federally or state-listed threatened and endangered species, occurs in the scrub and sandhill biomes of the North American Coastal Plain. Georeferenced occurrence points were used to …

Importance Of Local Weather And Environmental Gradients On Demography Of A Broadly Distributed Temperate Frog, Hallie Lingo, James C. Munger

Biology Faculty Publications and Presentations

Amphibian populations are sensitive to environmental temperatures and moisture, which vary with local weather conditions and may reach new norms and extremes as contemporary climate change progresses. Using long-term (11–16 years) mark-recapture data from 10 populations of the Columbia spotted frog (Rana luteiventris) from across its U.S. range, we addressed hypotheses about how demographic relationships to weather depend upon a population’s position along climate gradients. We estimated the effect of seasonal weather on annual survival probability and recruitment rates both within populations and across the species’ range from subalpine forests to semi-arid deserts. We calculated population-specific weather variables …

Self-Compassion Mediates The Link Between Attachment Security And Intimate Relationship Quality For Couples Navigating Pregnancy, Tuyen Huynh, Eric Phillips, Rebecca L. Brock

Department of Psychology: Faculty Publications

Millions of couples navigate the transition from pregnancy to postpartum in a given year, and this period of change and adjustment in the family is associated with elevated risk for intimate relationship dysfunction. Self-compassion has the potential to promote skills that are essential for healthy adaptation (e.g., emotion regulation, greater openness and flexibility, more awareness of the needs of oneself and one’s partner). The overarching goal of the present study was to investigate the role of self-compassion in intimate relationship quality during pregnancy. A sample of 159 couples completed semi-structured interviews and questionnaires. Parents engaging in more compassionate self-responding during …

Monitoring Extinction Risk And Threats Of The World's Fishes Based On The Sampled Red List Index, Rafael Miranda, Imanol Miqueleiz, William Darwall, Catherine Sayer, Nicholas K. Dulvy, Kent E. Carpenter, Beth Polidoro, Nadia Dewhurst-Richman, Caroline Pollock, Craig Hilton-Taylor, Robin Freeman, Ben Collen, Monika Böhm

Biological Sciences Faculty Publications

Global biodiversitytargets require us to identify species at risk of extinction and quantify status and trends of biodiversity. The Red List Index (RLI) tracks trends in the conservation status of entire species groups over time by monitoring changes in categories assigned to species. Here, we calculate this index for the world’s fishes in 2010, using a sampled approach to the RLI based on a randomly selected sample of 1,500 species, and also present RLI splits for freshwater and marine systems separately. We further compare specific traits of a worldwide fish list to our sample to assess its representativeness. Overall, 15.1% …

Ungulates Alter Plant Cover Without Consistent Effect On Soil Ecosystem Functioning, Miguel Ibañez-Alvarez, Elena Baraza, Emmanuel Serrano, Antonia Romero-Munar, Carles Cardona, Jordi Bartolome, Jennifer Adams Krumins

Department of Biology Faculty Scholarship and Creative Works

Shifts in animal husbandry and landscape use have significantly changed ungulate grazing effects on ecosystem functioning. These changes are now the subject of extensive research with respect to plant and soil communities, but the results of these studies are highly varied and context dependent. The objective of this study is to address contextual variation by holding all sampling methods and analytical approaches constant and analyse the effect of the feral goat (Capra hircus) population of Mallorca Island, Spain, on soil physical, chemical and biological characteristics across five controlled sites. Specifically, vegetation cover and soil properties in fenced plots excluded from …

Enhanced Immunoprecipitation Techniques For The Identification Of Rna-Binding Protein Partners: Igf2bp1 Interactions In Mammary Epithelial Cells, Saja A. Fakhraldeen, Scott M. Berry, David J. Beebe, Avtar Roopra, Celia M. Bisbach, Vladimir S. Spiegelman, Natalie M. Niemi, Caroline M. Alexander

Mechanical Engineering Faculty Publications

RNA-binding proteins (RBPs) regulate the expression of large cohorts of RNA species to produce programmatic changes in cellular phenotypes. To describe the function of RBPs within a cell, it is key to identify their mRNA-binding partners. This is often done by crosslinking nucleic acids to RBPs, followed by chemical release of the nucleic acid fragments for analysis. However, this methodology is lengthy, which involves complex processing with attendant sample losses, thus large amounts of starting materials and prone to artifacts. To evaluate potential alternative technologies, we tested “exclusion-based” purification of immunoprecipitates (IFAST or SLIDE) and report here that these methods …

Natural Phaeosphaeride A Derivatives Overcome Drug Resistance Of Tumor Cells And Modulate Signaling Pathways, Victoria Abzianidze, Natalia Moiseeva, Diana Suponina, Sofya Zakharenkova, Nadezhda Rogovskaya, Lidia Laletina, Alvin A. Holder, Denis Krivorotov, Alexander Bogachenkov, Alexander Garabadzhiu, Anton Ukolov, Vyacheslav Kosorukov

Chemistry & Biochemistry Faculty Publications

n the present study, natural phaeosphaeride A (PPA) derivatives are synthesized. Anti-tumor studies are carried out on the PC3, K562, HCT-116, THP-1, MCF-7, A549, NCI-H929, Jurkat, and RPMI8226 tumor cell lines, and on the human embryonic kidney (HEK293) cell line. All the compounds synthesized turned out to have better efficacy than PPA towards the tumor cell lines listed. Among them, three compounds exhibited an ability to overcome the drug resistance of tumor cells associated with the overexpression of the P-glycoprotein by modulating the work of this transporter. Luminex xMAP technology was used to assess the effect of five synthesized compounds …

Monarch Science Observer, Volume 13, College Of Sciences, Old Dominion University

College of Sciences Newsletter

Spring 2022, issue of Monarch Science Observer, ODU Colleges of Sciences Newsletter.

Bacteriophage That Infect Gordonia Species Show Varying Host Specificity And Infection, Lindsay Birge

Honors Program: Senior Projects (Public)

Bacteriophage (phage) are an incredibly abundant species of virus that infect bacteria. One major characteristic of phage is their small host range- many phage are known to infect only one or a few hosts. This phage and host relationship has led to phage therapy recently becoming highlighted as a possible alternative to traditional antibiotics in light of the growing antibiotic resistance crisis. The study of phage host specificity has risen in line with this concept, as a phage with a more extensive host range can provide more opportunities for use as an antibiotic. Samples of phage previously isolated on a …

Knowledge And Awareness Regarding Uses Of Extracted Natural Tooth In Clinical Practice, Momina Anis Motiwala, Shizrah Jamal, Karshma Devi, Rabia Ghafoor

Section of Dental-Oral Maxillofacial Surgery

Restoration of aesthetics is one the major patients’ concern in dentistry which may be disrupted due to tooth-loss secondary to trauma, or as part of orthodontic treatment or periodontal problem. A number of treatment options are available for the replacement of teeth, but they may be expensive, and time-consuming, involving artificial teeth. For immediate tooth replacement, patient’s own intentionally extracted or unintentionally avulsed tooth maybe used. The current narrative review was planned to discuss various techniques for the use of natural tooth pontic, which preserves the original contours, size and colour of the replaced tooth. Before using these teeth in …