Digital Commons Network^™

Mental Health Implications Of Isolation During Hospitalization For Covid-19: Self-Perceived Variations In Emotion, Rebekah Ruth Jones

Doctoral Dissertations and Projects

Forced isolation due to the COVID-19 pandemic has resulted in numerous mental health consequences. Individuals who have required hospitalization due to contracting the illness are at an increased risk of developing potentially harmful mental health concerns resulting from the emotional distress of forced isolation. Families separated from one another experience anxiety and fear due to helplessness fostered by the separation. Furthermore, medical caretakers are placed in the position to make life-altering decisions for their patients, increasing their stress and anxiety levels. Therefore, it is imperative that hospitals provide adequate mental health support for patients and their family members. Furthermore, communities …

A Multi-Site Case Study Of Christian School Leaders And Teachers Who Provide A Welcoming And Inclusive Environment For Students From Low Ses Backgrounds And/Or With Learning Differences, Amanda Blake Champion

Doctoral Dissertations and Projects

The purpose of this multi-site case study was to examine the intentional practices of Christian school leaders and teachers who strive to provide a welcoming and inclusive environment for students from low-socioeconomic (SES) backgrounds and/or with learning differences. The theory guiding this study is Bandura’s social cognitive theory. It connects the beliefs of self-efficacy held by school leaders and teachers to their values and philosophies, and their capability to include and welcome students from low SES backgrounds and/or with learning differences. This study investigated how school leaders and teachers welcome and include students from low SES backgrounds and/or with learning …

A Biblical Theology Of Water, Eric Robert Waller

Doctoral Dissertations and Projects

Numerous “water related terms” are utilized in Genesis 1-2 such as, “the deep, “the waters,” “water,” “sea,” seas,” “stream,” “river,” “flow,” “flows,” and “rain.” Arguably similar, Revelation 21-22 uses the terms “water of life,” “river of the water of life,” “thirsty,” “spring, ” and “lake.” That the traditional Protestant canon is bookended with such similar terminology appears to create an inclusio that demands further inquiry within the canon to seek supplemental, complementary, and even potentially contrasting and conflicting evidence supporting a biblical theology of water. While commentary on every canonical water related text or term would be a daunting task …

Middle School Teachers' Experiences Addressing Gifted Students' Basic Psychological Needs: A Phenomenological Study, Lorri Thibodeaux Caldwell

Doctoral Dissertations and Projects

This qualitative, hermeneutic phenomenological study aimed to investigate teachers’ experiences addressing the psychological needs of gifted middle school students within a public school district in Louisiana. Psychological needs-supportive teaching was defined as the pedagogies teachers employ to build students’ perceptions of autonomy, competence, and relatedness. The study was grounded in Deci and Ryan’s self-determination theory (SDT), which posits that human beings seek growth as part of human nature. The participants were a sample of 12 middle school teachers of identified gifted students in a Louisiana school district. Data collection included personal interviews, artifact submissions, and a focus group discussion. The …

Addressing The Impact Of Adverse Childhood Experiences Of Adults Through The Pastoral Counseling Ministry Of Victory Church, Joseph Randall Tapp

Doctoral Dissertations and Projects

Dr. Vincent Filetti's landmark 1998 study exposed the impact of adverse childhood experiences (ACEs) on children and adults. His analysis determined that childhood traumatic experiences could strongly correlate to serious health issues in adults. Exposure to childhood adversity has been shown to correlate not only with mental health issues such as depression, suicide, and substance abuse but also with chronic, life-threatening health issues such as cardiovascular disease, diabetes, cancer, and immune system issues. This DMin study aims to address the impact of ACEs on adult clients of the pastoral counseling ministry of Victory Church, a large non-denominational Christian church located …

Differences In Career Development Progress Between Sixth-Grade General And Special Education Students After Completing A Career Development Curriculum, Talonne Renee Gungle

Doctoral Dissertations and Projects

Career development is a lifelong process that begins in childhood and continues throughout adulthood. Little effort has been devoted to childhood career development; the focus is generally for older adolescents. The purpose of this study is to evaluate the differences in career development between general education and special education students who participate in a career development intervention and students that do not participate in the intervention. The results of this study are important to special education, so adequate interventions can be completed to better assist these students in career development. The study is a quasi-experimental nonequivalent control-group design that compares …

Understanding Contemporary Postsecondary Parental Academic Involvement: A Hermeneutic Phenomenological Research Inquiry, Dennis Allen Smith

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenology was to describe the experiences of college students who encounter negative parental academic involvement. The central question was, what are first- and second-year college students’ experiences with negative parental academic involvement? The theory guiding this study was the Hoover-Dempsey and Sandler (1995) parental involvement theory designed to analyze parents’ participation in a child’s education. The background includes the historical, social, and theoretical foundations warranting this study and the researcher’s motivations and philosophical assumptions. The participants were 14 first- and second-year students attending a community college, a public university, and a private university. Data collection …

Exploring The Impact Of Generational Trauma On Mother-Daughter Relationships With An Emphasis On The African American Community, Bernadette Denise Ward

Doctoral Dissertations and Projects

In many communities the mother-daughter relationship is not only vital in the younger years but also in the teen and young adult years. Several studies have explored a mother’s influence on her daughter’s views of the self, others, and the world in general. The mother-daughter relationship does not only impact personal morals and values but also the types of relationships the daughters gravitate to. In the African American community, many of the mother-daughter relationships are known to be similar in nature and/or dynamics throughout generations. Relationships that are tainted or known as toxic also seem to cycle throughout several generations. …

The Integration Of Neuroscience And Counseling Using Neuroeducation In Trauma Treatment: A Quantitative Study, Daniel Ross Wood

Doctoral Dissertations and Projects

Researchers in numerous professional fields, including psychology, have applied neuroscience integration in their studies. Yet research has also demonstrated a hesitancy among counselors to utilize neuro-informed principles in case conceptualization and treatment. No researchers in the studies found among the mental health counseling fields considered this issue. If left unaddressed, counselors and clinicians may avoid the use of an effective and complimentary integrative approach or unintentionally misapply neuro-informed principles and violate ethical standards in practice. This quantitative research used a survey and case study design to consider mental health professional characteristic variables of self-competency, theoretical attitude, and strength of religious …

Understanding Foster Care Elopement And Impact On Well-Being: A Phenomenological Study, Dana Monette Hart-Raynor

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand how elopement behaviors impacted short- and long-term well-being and daily functioning of older youth participating in North Carolina’s Foster Care 18 to 21 Program and foster care alumni in North Carolina. The theories guiding this research study were Bowlby’s attachment theory, Bronfenbrenner’s ecological systems theory, and Maslow’s hierarchy of needs. Fragmented relationships with foster caregivers were intensified with frequent elopement behaviors and problematic interpersonal relationships continued to manifest after foster care exiting. Fostered youth, their caregivers, child welfare professionals, and the community-at-large were impacted by the youth’s decision to elope. The …

Gendered Pastoral Care: A Hermeneutic Phenomenological Study Of The Lived Experiences Of Parishioners, Joshua D. Phelan

Doctoral Dissertations and Projects

Pastoral care has a rich theological history which guides modern care applications. Pastoral care is generally understood as helping acts meant to guide believers toward spiritual formation (Clebsch & Jaekle, 1983). Gendered pastoral leadership could have an impact in how pastoral care is experienced by church parishioners. The purpose of this phenomenological study was to explore the lived experiences of twelve parishioners who had received pastoral care under both a male and a female lead pastor at three churches. Eagly’s (1987) social role theory served as a theoretical framework for this study. This research utilized personal interviews to collect data …

A Hermeneutic Phenomenological Study: Perspectives On The Parental Engagement Strategies Of Rural African American Parents Of Middle School Students, Barbara Ragin Champagne

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to explore and ascribe meaning to African American parents' lived experiences in the education of their middle school students in rural east-central South Carolina. Two theoretical frameworks guided this study as they related to the levels and the effect of parental self-efficacy on parental engagement: Hoover-Dempsey and Sandler's revised model of parental involvement and Bandura's self-efficacy theory. The central research question for this study was "What are the perceptions and lived experiences of rural African American middle-school parents and their involvement in parental engagement activities?" Three subsequent sub-questions on parental self-efficacy, role …

Temporal And Spatial Metabolite Dynamics Impart Control In Adipogenesis, Kristin Eckel-Mahan

Faculty, Staff and Student Publications

The process of adipogenesis is critical for forming new, healthy adipocytes that are capable of storing lipids. In this issue, Sánchez-Ramírez and Ung et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202111137) reveal a novel role for the metabolite nicotinamide adenine dinucleotide in controlling differentiation of mesenchymal stromal cells into adipocytes.

Synthesis, Identification, Theoretical Study, And Effect Of The New Heterocyclic System From Ciprofloxacin Derivatives On The Activity Of Some Liver Enzymes, Amaal S. Sadiq, Zahraa T. Khudhair, Selvana A. Yousif, Wasan A. R. Mahmood

Baghdad Science Journal

The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to …

Predicting The Outcomes Of Internet-Based Cognitive Behavioral Therapy For Tinnitus: Applications Of Artificial Neural Network And Support Vector Machine, Hansapani Rodrigo, Eldré W. Beukes, Gerhard Andersson, Vinaya Manchaiah

School of Mathematical & Statistical Sciences Faculty Publications

Purpose:

Internet-based cognitive behavioral therapy (ICBT) has been found to be effective for tinnitus management, although there is limited understanding about who will benefit the most from ICBT. Traditional statistical models have largely failed to identify the nonlinear associations and hence find strong predictors of success with ICBT. This study aimed at examining the use of an artificial neural network (ANN) and support vector machine (SVM) to identify variables associated with treatment success in ICBT for tinnitus.

Method:

The study involved a secondary analysis of data from 228 individuals who had completed ICBT in previous intervention studies. A 13-point reduction …

Heavy Metal Complexes Of 1, 2, 3-Triazole Derivative: Synthesis, Characterization, And Cytotoxicity Appraisal Against Breast Cancer Cell Lines (Mda-Mb-231), Jihan Hameed Abdulameer, Mahasin F. Alias

Baghdad Science Journal

New chelating ligand derived from triazole and its complexes with metal ions Rhodium, Platinum and Gold were synthesized. Through a copper (I)-catalyzed click reaction, the ligand produced 1,3-dipolar cycloaddition between 2,6-bis((prop-2-yn-1-yloxy) methyl) pyridine and 1-azidododecane. All structures of these new compounds were rigorously characterized in the solid state using spectroscopic techniques like: 1HNMR, 13CNMR, Uv-Vis, FTIR, metal and elemental analyses, magnetic susceptibility and conductivity measurements at room temperature, it was found that the ligand acts as a penta and tetradentate chelate through N3O2, N2O2, and the geometry of the new complexes are identified as octahedral for (Rh & Pt) complexes …

Biodegradation Of Perfluorooctanoic Acid By Pseudomonas Plecoglossicida Strain Dd4, Sergey P. Chetverikov, Danil A. Sharipov

Baghdad Science Journal

Organofluorines, as a pollutant, belongs to a group of substances which are very difficult to neutralize. They are part of many products of everyday use and for this reason they pollute the environment in large quantities. Perfluorinated carboxylic acids are entered into the list of the “Stockholm Convention on Persistent Organic Pollutants” in order to minimize the load on the environment by significantly reducing their use, up to their complete rejection. The DD4 strain was isolated from the soil by the enrichment method and identified using 16S rRNA method as Pseudomonas plecoglossicida. It is able to metabolize perfluorooctanoic acid (PFOA) …

Prophylaxis And Remediation For Future Pandemic Pathogens-(Lessons From A Post-Covid World), Mark E. Obrenovich, Moncef B. Tayahi, Caryn L. Heidt, Steven N. Emancipator

Michigan Tech Publications, Part 1

Since influenza and coronaviruses are currently deadly and emerging threats worldwide, better treatment, remediation and prevention options are needed. In that regard, a basic understanding of severe acute respiratory syndrome (SARS)-CoV-2/COVID-19 () and other viral pathogen mechanisms of transmission are expected. Unfortunately, unprecedented, and growing distrust of vaccines and even masks or personal protective equipment (PPE) in the United States and elsewhere presents itself as an added challenge. We postulate that development of improved and highly effective prophylactic measures, together with new life-saving therapies that do inhibit or otherwise treat infection of SARS-CoV-2, influenza and other viral pathogens, could be …

K-Nearest Neighbor Method With Principal Component Analysis For Functional Nonparametric Regression, Shelan Saied Ismaeel, Kurdistan M.Taher Omar, Bo Wang

Baghdad Science Journal

This paper proposed a new method to study functional non-parametric regression data analysis with conditional expectation in the case that the covariates are functional and the Principal Component Analysis was utilized to de-correlate the multivariate response variables. It utilized the formula of the Nadaraya Watson estimator (K-Nearest Neighbour (KNN)) for prediction with different types of the semi-metrics, (which are based on Second Derivative and Functional Principal Component Analysis (FPCA)) for measureing the closeness between curves. Root Mean Square Errors is used for the implementation of this model which is then compared to the independent response method. R program is used …

Influence Of Silver And Copper Nanoparticles On The Enzymatic Activity Of Soil-Borne Microorganisms, Lyudmila I Zaynitdinova, Roxila N Juraeva, Javlon J Tashpulatov, Svetlana I Kukanova, Nikolay A Lazutin, Aziza M Mavjudova

Baghdad Science Journal

Influence of metal nanoparticles synthesized by microorganisms upon soil-borne microscopic fungus Aspergillus terreus K-8 was studied. It was established that the metal nanoparticles synthesized by microorganisms affect the enzymatic activity of the studied culture. Silver nanoparticles lead to a decrease in cellulase activity and completely suppress the amylase activity of the fungus, while copper nanoparticles completely inhibit the activity of both the cellulase complex and amylase. The obtained results imply that the large-scale use of silver and copper nanoparticles may disrupt biological processes in the soil and cause change in the physiological and biochemical state of soil-borne microorganisms as well.

Influence Of Optical Fiber Diameters On The Performance Of Surface Plasmon Resonance Sensor, Haider Y. Hammod, Tammara Jamal Mossa

Baghdad Science Journal

In this research, a sensor for chemical solutions was designed and formed using optical fiber-based on a surface Plasmon resonance technology. A single-mode optical fiber with three different diameters (25, 45 and 65) µm was used, respectively. The second layer of the low refractive fiber was replaced by gold, which was electrically deposited at 40 µm thickness. For each of the three types of optical fiber, different saline concentrations (different index of refraction) were used to evaluate the performance of the refractive index sensor (chemical sensor) by measuring its sensitivity and resolutions. The highest values we could get for these …

Effects Of Castor Oil Nanoemulsion Extracted By Hexane On The Fourth Larval Stage Of Culex Quinquefsciatus From Al Hawizeh Marsh/Iraq, And Non- Targeted Organism, Alla Abd Al Hassan Al Hilfy, Soolaf A. Kathiar, Hazim Idan Al Shammari

Baghdad Science Journal

The current study aims to show the importance of plant products as mosquitocides against Culex quinquefasciatus. Castor oil Nanoemulsions were subedit in various ratios including castor oil, ethanol, tween 80, and deionized water by using ultrasonication. Thermodynamic, centrifugation, PH, assay which improved that the formula of 10 ml of castor oil, ethanol 5ml, tween 80 (14 ml) and deionized water 71ml was more stable than other formulas. The stable formula of castor oil nanoemulsion was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Nanoemulsion droplets were spherical in shape and were found to have a Z-average diameter …

Impact Of International Travel And Diarrhea On Gut Microbiome And Resistome Dynamics, Manish Boolchandani, Kevin S Blake, Drake H Tilley, Miguel M Cabada, Drew J Schwartz, Sanket Patel, Maria Luisa Morales, Rina Meza, Giselle Soto, Sandra D Isidean, Chad K Porter, Mark P Simons, Gautam Dantas

2020-Current year OA Pubs

International travel contributes to the global spread of antimicrobial resistance. Travelers' diarrhea exacerbates the risk of acquiring multidrug-resistant organisms and can lead to persistent gastrointestinal disturbance post-travel. However, little is known about the impact of diarrhea on travelers' gut microbiomes, and the dynamics of these changes throughout travel. Here, we assembled a cohort of 159 international students visiting the Andean city of Cusco, Peru and applied next-generation sequencing techniques to 718 longitudinally-collected stool samples. We find that gut microbiome composition changed significantly throughout travel, but taxonomic diversity remained stable. However, diarrhea disrupted this stability and resulted in an increased abundance …

Selective Vulnerability Of The Intermediate Retinal Capillary Plexus Precedes Retinal Ganglion Cell Loss In Ocular Hypertension, Priyamvada M Pitale, Guofu Shen, Rohini R Sigireddi, Maria Polo-Prieto, Yong H Park, Solomon E Gibson, Peter D Westenskow, Roomasa Channa, Benjamin J Frankfort

Faculty, Staff and Students Publications

Introduction: Glaucoma, a disease of retinal ganglion cell (RGC) injury and potentially devastating vision loss, is associated with both ocular hypertension (OHT) and reduced ocular blood flow. However, the relationship between OHT and retinal capillary architecture is not well understood. In this project, we studied microvasculature damage in mice exposed to mild levels of induced OHT.

Methods: Mild OHT was induced with the microbead model for 2 weeks. At this time point, some retinas were immunostained with CD31 (endothelium), Collagen IV (basement membrane), and RBPMS (RGCs) for z-stack confocal microscopy. We processed these confocal images to distinguish the three retinal …

Cold Plasma Technology In Food Packaging, Kalpani Y. Perera, Jack Prendeville, Amit K. Jaiswal, Swarna Jaiswal

Articles

Cold plasma (CP) is an effective strategy to alter the limitations of biopolymer materials for food packaging applications. Biopolymers such as polysaccharides and proteins are known to be sustainable materials with excellent film-forming properties. Bio-based films can be used as an alternative to traditional plastic packaging. There are limitations to biopolymer packaging materials such as hydrophobicity, poor barrier, and thermos-mechanical properties. For this reason, biopolymers must be modified to create a packaging material with the desired applicability. CP is an effective method to enhance the functionality and interfacial features of biopolymers. It etches the film surface allowing for better adhesion …

Activity Disruption Causes Degeneration Of Entorhinal Neurons In A Mouse Model Of Alzheimer’S Circuit Dysfunction, Rong Zhao, Stacy D Grunke, Caleb A Wood, Gabriella A Perez, Melissa Comstock, Ming-Hua Li, Anand K Singh, Kyung-Won Park, Joanna L Jankowsky

Faculty, Staff and Students Publications

Neurodegenerative diseases are characterized by selective vulnerability of distinct cell populations; however, the cause for this specificity remains elusive. Here, we show that entorhinal cortex layer 2 (EC2) neurons are unusually vulnerable to prolonged neuronal inactivity compared with neighboring regions of the temporal lobe, and that reelin + stellate cells connecting EC with the hippocampus are preferentially susceptible within the EC2 population. We demonstrate that neuronal death after silencing can be elicited through multiple independent means of activity inhibition, and that preventing synaptic release, either alone or in combination with electrical shunting, is sufficient to elicit silencing-induced degeneration. Finally, we …

Federated Learning Enables Big Data For Rare Cancer Boundary Detection, Sarthak Pati, Ujjwal Baid, Brandon Edwards, Micah Sheller, Shih-Han Wang, G Anthony Reina, Patrick Foley, Alexey Gruzdev, Deepthi Karkada, Christos Davatzikos, Chiharu Sako, Satyam Ghodasara, Michel Bilello, Suyash Mohan, Philipp Vollmuth, Gianluca Brugnara, Chandrakanth J Preetha, Felix Sahm, Klaus Maier-Hein, Maximilian Zenk, Martin Bendszus, Wolfgang Wick, Evan Calabrese, Jeffrey Rudie, Javier Villanueva-Meyer, Soonmee Cha, Madhura Ingalhalikar, Manali Jadhav, Umang Pandey, Jitender Saini, John Garrett, Matthew Larson, Robert Jeraj, Stuart Currie, Russell Frood, Kavi Fatania, Raymond Y Huang, Ken Chang, Carmen Balaña, Jaume Capellades, Josep Puig, Johannes Trenkler, Josef Pichler, Georg Necker, Andreas Haunschmidt, Stephan Meckel, Gaurav Shukla, Spencer Liem, Gregory S Alexander, Joseph Lombardo, Joshua D Palmer, Adam E Flanders, Adam P Dicker, Haris I Sair, Craig K Jones, Archana Venkataraman, Meirui Jiang, Tiffany Y So, Cheng Chen, Pheng Ann Heng, Qi Dou, Michal Kozubek, Filip Lux, Jan Michálek, Petr Matula, Miloš Keřkovský, Tereza Kopřivová, Marek Dostál, Václav Vybíhal, Michael A Vogelbaum, J Ross Mitchell, Joaquim Farinhas, Joseph A Maldjian, Chandan Ganesh Bangalore Yogananda, Marco C Pinho, Divya Reddy, James Holcomb, Benjamin C Wagner, Benjamin M Ellingson, Timothy F Cloughesy, Catalina Raymond, Talia Oughourlian, Akifumi Hagiwara, Chencai Wang, Minh-Son To, Sargam Bhardwaj, Chee Chong, Marc Agzarian, Alexandre Xavier Falcão, Samuel B Martins, Bernardo C A Teixeira, Flávia Sprenger, David Menotti, Diego R Lucio, Pamela Lamontagne, Daniel Marcus, Benedikt Wiestler, Florian Kofler, Ivan Ezhov, Marie Metz, Rajan Jain, Matthew Lee, Yvonne W Lui, Richard Mckinley, Johannes Slotboom, Piotr Radojewski, Raphael Meier, Roland Wiest, Derrick Murcia, Eric Fu, Rourke Haas, John Thompson, David Ryan Ormond, Chaitra Badve, Andrew E Sloan, Vachan Vadmal, Kristin Waite, Rivka R Colen, Linmin Pei, Murat Ak, Ashok Srinivasan, J Rajiv Bapuraj, Arvind Rao, Nicholas Wang, Ota Yoshiaki, Toshio Moritani, Sevcan Turk, Joonsang Lee, Snehal Prabhudesai, Fanny Morón, Jacob Mandel, Konstantinos Kamnitsas, Ben Glocker, Luke V M Dixon, Matthew Williams, Peter Zampakis, Vasileios Panagiotopoulos, Panagiotis Tsiganos, Sotiris Alexiou, Ilias Haliassos, Evangelia I Zacharaki, Konstantinos Moustakas, Christina Kalogeropoulou, Dimitrios M Kardamakis, Yoon Seong Choi, Seung-Koo Lee, Jong Hee Chang, Sung Soo Ahn, Bing Luo, Laila Poisson, Ning Wen, Pallavi Tiwari, Ruchika Verma, Rohan Bareja, Ipsa Yadav, Jonathan Chen, Neeraj Kumar, Marion Smits, Sebastian R Van Der Voort, Ahmed Alafandi, Fatih Incekara, Maarten M J Wijnenga, Georgios Kapsas, Renske Gahrmann, Joost W Schouten, Hendrikus J Dubbink, Arnaud J P E Vincent, Martin J Van Den Bent, Pim J French, Stefan Klein, Yading Yuan, Sonam Sharma, Tzu-Chi Tseng, Saba Adabi, Simone P Niclou, Olivier Keunen, Ann-Christin Hau, Martin Vallières, David Fortin, Martin Lepage, Bennett Landman, Karthik Ramadass, Kaiwen Xu, Silky Chotai, Lola B Chambless, Akshitkumar Mistry, Reid C Thompson, Yuriy Gusev, Krithika Bhuvaneshwar, Anousheh Sayah, Camelia Bencheqroun, Anas Belouali, Subha Madhavan, Thomas C Booth, Alysha Chelliah, Marc Modat, Haris Shuaib, Carmen Dragos, Aly Abayazeed, Kenneth Kolodziej, Michael Hill, Ahmed Abbassy, Shady Gamal, Mahmoud Mekhaimar, Mohamed Qayati, Mauricio Reyes, Ji Eun Park, Jihye Yun, Ho Sung Kim, Abhishek Mahajan, Mark Muzi, Sean Benson, Regina G H Beets-Tan, Jonas Teuwen, Alejandro Herrera-Trujillo, Maria Trujillo, William Escobar, Ana Abello, Jose Bernal, Jhon Gómez, Joseph Choi, Stephen Baek, Yusung Kim, Heba Ismael, Bryan Allen, John M Buatti, Aikaterini Kotrotsou, Hongwei Li, Tobias Weiss, Michael Weller, Andrea Bink, Bertrand Pouymayou, Hassan F Shaykh, Joel Saltz, Prateek Prasanna, Sampurna Shrestha, Kartik M Mani, David Payne, Tahsin Kurc, Enrique Pelaez, Heydy Franco-Maldonado, Francis Loayza, Sebastian Quevedo, Pamela Guevara, Esteban Torche, Cristobal Mendoza, Franco Vera, Elvis Ríos, Eduardo López, Sergio A Velastin, Godwin Ogbole, Mayowa Soneye, Dotun Oyekunle, Olubunmi Odafe-Oyibotha, Babatunde Osobu, Mustapha Shu'aibu, Adeleye Dorcas, Farouk Dako, Amber L Simpson, Mohammad Hamghalam, Jacob J Peoples, Ricky Hu, Anh Tran, Danielle Cutler, Fabio Y Moraes, Michael A Boss, James Gimpel, Deepak Kattil Veettil, Kendall Schmidt, Brian Bialecki, Sailaja Marella, Cynthia Price, Lisa Cimino, Charles Apgar, Prashant Shah, Bjoern Menze, Jill S Barnholtz-Sloan, Jason Martin, Spyridon Bakas

Faculty, Staff and Student Publications

Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically …

Complexity Of Progranulin Mechanisms Of Action In Mesothelioma, Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression. Recent data from our laboratories have demonstrated that progranulin and its receptor, EphA2, constitute an oncogenic pathway in bladder cancer by promoting motility, invasion and in vivo tumor formation. Progranulin and EphA2 are expressed in mesothelioma cells but their mechanisms of action are not well defined. In addition, there are no data establishing whether the progranulin/EphA2 axis is tumorigenic for mesothelioma cells.

Methods: The expression of progranulin in various mesothelioma cell …

Federated Learning Enables Big Data For Rare Cancer Boundary Detection, Sarthak Pati, Pamela Lamontagne, Daniel Marcus, Et Al.

2020-Current year OA Pubs

No abstract provided.

The Polyamine Spermine Potentiates The Propagation Of Negatively Charged Molecules Through The Astrocytic Syncytium, Jan Benedikt, Christian J Malpica-Nieves, Yomarie Rivera, Miguel Méndez-González, Colin G Nichols, Rüdiger W Veh, Misty J Eaton, Serguei N Skatchkov

2020-Current year OA Pubs

The interest in astrocytes, the silent brain cells that accumulate polyamines (PAs), is growing. PAs exert anti-inflammatory, antioxidant, antidepressant, neuroprotective, and other beneficial effects, including increasing longevity in vivo. Unlike neurons, astrocytes are extensively coupled to others via connexin (Cx) gap junctions (GJs). Although there are striking modulatory effects of PAs on neuronal receptors and channels, PA regulation of the astrocytic GJs is not well understood. We studied GJ-propagation using molecules of different (i) electrical charge, (ii) structure, and (iii) molecular weight. Loading single astrocytes with patch pipettes containing membrane-impermeable dyes, we observed that (i) even small molecules do not …