Digital Commons Network^™

Faculty Making The Emergency Online Transition During The Covid-19 Pandemic: Effects Of Prior Online Teaching Experience And Strategies Used To Learn To Teach Online (Special Edition 2022), Edward Hebert, Ralph Wood, Kwonchan Jeon, Ismatara Reena

Higher Learning Research Communications

Objectives: During the COVID-19 pandemic, university faculty experienced an emergency pivot to online instruction in the Spring 2020 semester. Many had no prior online teaching experience and were given little time to adapt. This study examines pre-pandemic online teaching experience and training strategies used to learn how to teach online during the emergency remote teaching semester, perceptions of change in online teaching ability and the pandemic’s impact on teaching effectiveness, and interest in future online teaching opportunities.

Method: Full-time faculty (n = 455) from four public regional universities in the southern United States completed a survey at …

Effect Of Neoadjuvant Chemotherapy On Intraoperative Core Temperature In Patients With Breast Cancer: A Retrospective Cohort Study, Daniel B Zamler, Takashi Shingu, Laura M Kahn, Kristin Huntoon, Cynthia Kassab, Katarzyna Tomczak, Yating Li, Ivy Lai, Rocio Zorilla-Veloz, Cassian Yee, Kunal Rai, Betty Ys Kim, Stephanie S Watowich, Amy B Heimberger, Giulio F Draetta, Jian Hu

Faculty, Staff and Student Publications

Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do not recapitulate human disease. To address this challenge, we took advantage of our previously developed spontaneous Qk/Trp53/Pten (QPP) triple-knockout model of human GBM, comparing the immune microenvironment of QPP mice with that of patient-derived tumors to determine whether this model provides opportunity for gaining insights into tumor physiopathology and preclinical evaluation of therapeutic agents. Immune profiling analyses and single-cell sequencing of implanted and spontaneous tumors from QPP mice and from patients with glioma revealed intratumoral immune components that …

Immune Landscape Of A Genetically Engineered Murine Model Of Glioma Compared With Human Glioma, Daniel B Zamler, Takashi Shingu, Laura M Kahn, Kristin Huntoon, Cynthia Kassab, Katarzyna Tomczak, Yating Li, Ivy Lai, Rocio Zorilla-Veloz, Cassian Yee, Kunal Rai, Betty Ys Kim, Stephanie S Watowich, Amy B Heimberger, Giulio F Draetta, Jian Hu

Faculty, Staff and Student Publications

Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do not recapitulate human disease. To address this challenge, we took advantage of our previously developed spontaneous Qk/Trp53/Pten (QPP) triple-knockout model of human GBM, comparing the immune microenvironment of QPP mice with that of patient-derived tumors to determine whether this model provides opportunity for gaining insights into tumor physiopathology and preclinical evaluation of therapeutic agents. Immune profiling analyses and single-cell sequencing of implanted and spontaneous tumors from QPP mice and from patients with glioma revealed intratumoral immune components that …

Biochemical, Biophysical, And Immunological Characterization Of Respiratory Secretions In Severe Sars-Cov-2 Infections, Elizabeth B Burgener, Mark R Nicolls, Michael G Ozawa, Donald P Regula, Ana E Pacheco-Navarro, Samuel Yang, Vinicio A De Jesus Perez, Harry Karmouty-Quintana, Andrew M Peters, Bihong Zhao, Maximilian L Buja, Pamela Y Johnson, Robert B Vernon, Thomas N Wight, Carlos E Milla, Angela J Rogers, Andrew J Spakowitz, Sarah C Heilshorn, Paul L Bollyky

Faculty, Staff and Student Publications

Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to flow) of respiratory secretions collected from intubated COVID-19 patients. We found the percentages of solids and protein content were greatly elevated in COVID-19 compared with heathy control samples and closely resembled levels seen in cystic fibrosis, a genetic disease known for thick, tenacious respiratory secretions. DNA and hyaluronan (HA) were major components of respiratory secretions in COVID-19 and were likewise abundant in cadaveric lung tissues from these …

Work-Related Ipv Among Latinos: Exploring The Roles Of Fatherhood Status, Gendered Expectations, And Support For Intimate Partner's Employment, Adrian Luis Manriquez

Dissertations and Theses

IPV can spill over from individuals' personal lives into their work lives. Men's work-related IPV perpetration has been found to negatively impact their work performance and employment outcomes. Additionally, acculturation, lack of support for an intimate partner's maintenance employment, and traditional gender role expectations may have an impact on Latinos' work-related IPV perpetration. However, it is plausible that fatherhood can serve as a point of intervention for ending men's IPV perpetration. The current study aimed to examine the moderating effect of fatherhood status on the relationship between various risk factors for IPV perpetration and work-related IPV behaviors among Latinos. Additionally, …

Antigenic Landscapes On Staphylococcus Aureus Pore-Forming Toxins Reveal Insights Into Specificity And Cross-Neutralization, Shweta Kailasan, Ravi Kant, Madeleine Noonan-Shueh, Tulasikumari Kanipakala, Grant Liao, Sergey Shulenin, Daisy W Leung, Richard A Alm, Rajan P Adhikari, Gaya K Amarasinghe, Michael L Gross, M Javad Aman

2020-Current year OA Pubs

No abstract provided.

Blocking Cell Cycle Progression Through Cdk4/6 Protects Against Chronic Kidney Disease, Yosuke Osaki, Marika Manolopoulou, Alla V Ivanova, Nicholas Vartanian, Melanie Phillips Mignemi, Justin Kern, Jianchun Chen, Haichun Yang, Agnes B Fogo, Mingzhi Zhang, Cassianne Robinson-Cohen, Leslie S. Gewin

2020-Current year OA Pubs

Acute and chronic kidney injuries induce increased cell cycle progression in renal tubules. While increased cell cycle progression promotes repair after acute injury, the role of ongoing tubular cell cycle progression in chronic kidney disease is unknown. Two weeks after initiation of chronic kidney disease, we blocked cell cycle progression at G1/S phase by using an FDA-approved, selective inhibitor of CDK4/6. Blocking CDK4/6 improved renal function and reduced tubular injury and fibrosis in 2 murine models of chronic kidney disease. However, selective deletion of cyclin D1, which complexes with CDK4/6 to promote cell cycle progression, paradoxically increased tubular injury. Expression …

Vitamin D Treatment Prevents Uremia-Induced Reductions In Aortic Microrna-145 Attenuating Osteogenic Differentiation Despite Hyperphosphatemia, Natalia Carrillo-López, Sara Panizo, Maria Vittoria Arcidiacono, Sandra De La Fuente, Laura Martínez-Arias, Emerenziana Ottaviano, Catalina Ulloa, María Piedad Ruiz-Torres, Isabel Rodríguez, Jorge B Cannata-Andía, Manuel Naves-Díaz, Adriana S Dusso

2020-Current year OA Pubs

In chronic kidney disease, systemic inflammation and high serum phosphate (P) promote the de-differentiation of vascular smooth muscle cells (VSMC) to osteoblast-like cells, increasing the propensity for medial calcification and cardiovascular mortality. Vascular microRNA-145 (miR-145) content is essential to maintain VSMC contractile phenotype. Because vitamin D induces aortic miR-145, uremia and high serum P reduce it and miR-145 directly targets osteogenic osterix in osteoblasts, this study evaluated a potential causal link between vascular miR-145 reductions and osterix-driven osteogenic differentiation and its counter-regulation by vitamin D. Studies in aortic rings from normal rats and in the rat aortic VSMC line A7r5 …

A Pathogenic Mechanism Associated With Myopathies And Structural Birth Defects Involves Tpm2-Directed Myogenesis, Jennifer Mcadow, Shuo Yang, Tiffany Ou, Gary Huang, Matthew B. Dobbs, Christina A. Gurnett, Michael J. Greenberg, Aaron N. Johnson

2020-Current year OA Pubs

Nemaline myopathy (NM) is the most common congenital myopathy, characterized by extreme weakness of the respiratory, limb, and facial muscles. Pathogenic variants in Tropomyosin 2 (TPM2), which encodes a skeletal muscle-specific actin binding protein essential for sarcomere function, cause a spectrum of musculoskeletal disorders that include NM as well as cap myopathy, congenital fiber type disproportion, and distal arthrogryposis (DA). The in vivo pathomechanisms underlying TPM2-related disorders are unknown, so we expressed a series of dominant, pathogenic TPM2 variants in Drosophila embryos and found 4 variants significantly affected muscle development and muscle function. Transient overexpression of the 4 variants also …

Review Of Cannabis Use Among Aboriginal And Torres Strait Islander People, Julia Butt, Mandy Wilson, Jocelyn Jones, Simon Lenton

Journal of the Australian Indigenous HealthInfoNet

The health effects of cannabis use may not always be seen as a high priority for Aboriginal and Torres Strait Islander communities. However, the impact of cannabis use on physical and mental health can have significant consequences. It is known that the use of high potency cannabis has increased over the last two decades, with a corresponding increased risk to health. In particular, young people are at increased risk of experiencing harms to mental health. Physical harms to health include effects on the respiratory system, cardiovascular system, an increased risk of cancer, and in-utero effects from maternal use. The review …

A New Species Of Chiromachetes Pocock, 1899 (Scorpiones: Hormuridae) From Southern Western Ghats, India, Akshay Khandekar, Tejas Thackeray, Swapnil Pawar, Satpal Gangalmale, Vivek Waghe

Euscorpius

No abstract provided.

The Effects Of Resistance Training On Physical Fitness And Neuromotor-Cognitive Functions In Adults With Down Syndrome, Emily M. Post, William J. Kraemer, Madison L. Kackley, Lydia K. Caldwell, Jeff S. Volek, Barbara N. Sanchez, Brian C. Focht, Robert U. Newton, Keijo Häkkinen, Carl M. Maresh

Health and Sport Sciences Faculty Scholarship

Adults with Down syndrome are an underserved population at high risk for a host of different pathologies from aging and lack of activity.

Purpose: To examine the effects of a 10-week resistance training program on measures of motor behavior, cognitive function, mood, and physical fitness.

Methods: Participants (n = 11) were men and women clinically diagnosed with Down syndrome (age: 25.8 ± 6.4 years; height: 151.5 ± 8.3 cm; weight: 67.5 ± 13.0 kg; IQ: 58.3 ± 19.7 units). After familiarization of testing procedures, subjects performed The Arizona Cognitive Test Battery for Down Syndrome, TGMD-2, lower and upper body …

Prognostic Microrna Panel For Hcv-Associated Hcc: Integrating Computational Biology And Clinical Validation, Areeg M. Dabbish, Hana M. Abdelzaher, Moustafa Abohawya, Samir Shamma

Faculty Journal Articles

No abstract provided.

Space Bioprocess Engineering On The Horizon, Aaron J. Berliner, Isaac Lipsky, Davian Ho, Jacob M. Hilzinger, Gretchen Vengerova, Georgios Makrygiorgos, Matthew J. Mcnulty, Kevin Yates, Nils J. H. Averesch, Charles S. Cockell, Tyler Wallentine, Lance C. Seefeldt, Craig S. Criddle, Somen Nandi, Karen A. Mcdonald, Amor A. Menezes, Ali Mesbah, Adam P. Arkin

Chemistry and Biochemistry Faculty Publications

Space bioprocess engineering (SBE) is an emerging multi-disciplinary field to design, realize, and manage biologically-driven technologies specifically with the goal of supporting life on long term space missions. SBE considers synthetic biology and bioprocess engineering under the extreme constraints of the conditions of space. A coherent strategy for the long term development of this field is lacking. In this Perspective, we describe the need for an expanded mandate to explore biotechnological needs of the future missions. We then identify several key parameters—metrics, deployment, and training—which together form a pathway towards the successful development and implementation of SBE technologies of the …

22 Arts & Sciences Professors Awarded Faculty Fellowship During 2022-23, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Anti-Bat Ultrasound Production In Moths Is Globally And Phylogenetically Widespread, Jesse R. Barber, Brian C. Leavell, Krystie A. Miner, Brandt Quirk-Royal

Biology Faculty Publications and Presentations

Warning signals are well known in the visual system, but rare in other modalities. Some moths produce ultrasonic sounds to warn bats of noxious taste or to mimic unpalatable models. Here, we report results from a long-term study across the globe, assaying moth response to playback of bat echolocation. We tested 252 genera, spanning most families of large-bodied moths, and document anti-bat ultrasound production in 52 genera, with eight subfamily origins described. Based on acoustic analysis of ultrasonic emissions and palatability experiments with bats, it seems that acoustic warning and mimicry are the raison d'être for sound production in most …

Interview With Joan Davison, Joan Davison, Wenxian Zhang

Oral Histories

Joan Davison (nee Doverspike) received her doctorate in Government and International Affairs from the University of Notre Dame in 1984 where she served as a University Fellow. Her research focused upon US – Soviet relations and US Foreign Policy. Previously she earned a BA summa cum laude from Wheeling University. While at Wheeling, the College awarded her an athletics scholarship – its first ever to a female student. In 1978, she received the Alumni Scholar-Athlete Award, again the first female recipient. In 1987 she was inducted into the Wheeling Athletics Hall of Fame as a Charter Member. In 2012, she …

Mindfulness To Promote Healthy Aging In Older Adults With Mild Cognitive Impairment And Their Caregivers: A Mixed Methods Feasibility And Acceptability Study, Emma Mcbride

Theses and Dissertations

Mild cognitive impairment (MCI), thought be a precursor to dementia, is characterized by cognitive decline without functional impairment. As the population ages and the prevalence of MCI increases, non-pharmacologic interventions are needed to address well-being and disease progression in this population of older adults and their caregivers. In response to growing interest in mindfulness-based interventions (MBIs) as an adjunct to integrated care for this population, this single arm, mixed methods pilot study trialed a lightly adapted, 6-week MBI for both MCI patients and their caregivers (n=24). The intervention was feasible and acceptable in both groups. There was a trend toward …

Disturbance Ecology Of The Sonadora River Rock Pool Insect Assemblage At Luquillo Experimental Forest, Puerto Rico, Patrick Gilkey

Master's Theses

Freshwater rock pools can serve as habitat for aquatic insects. Flash-flooding can have profound effects on insect communities in streams and rivers, but these effects have not been studied on freshwater rock pools. The goal of this thesis was to describe ecological patterns of the Sonadora River rock pool insect community at the Luquillo Experiment Forrest, Puerto Rico, specifically in response to intense flash-flooding, and then perform experiments to elucidate possible processes to explain those patterns. The rock pools contained primarily three taxa of Dipteran (true-fly) larvae, in order of decreasing abundance, 1) a newly discovered species of ceratopogonid (biting …

Chronological Accumulation Of Microplastics In The Gulf Of Mexico And Their Acute Effects On Coral Bleaching, Martina M. Plafcan

USF Tampa Graduate Theses and Dissertations

Microplastics have accumulated in the environment since plastic production began. They have spread to all areas of the globe from marine trenches to mountains and they can be harmful to organisms. However, research on microplastics has only recently begun so it is unclear how they have changed over time in many regions of the ocean and how current oceanic concentrations might affect marine life. Additionally, organisms such as corals are under stress and have been declining due to climate change, so it is not yet known if microplastics exacerbate these threats. My thesis addressed these gaps in the literature by …

“That’S What We Call ‘Aesthetics’”: The Social Construction Of Tap Water Mistrust In An Underbounded Community, Abby Vidmar

USF Tampa Graduate Theses and Dissertations

Recent research on water insecurity in the United States has revealed that underbounded communities — urban disadvantaged unincorporated neighborhoods characterized by high-poverty and high residential density lying just outside the border of an incorporated municipality — often lack consistent access to clean and safe water. In these settings, poor water quality and inadequate infrastructure shape residents’ risk perceptions often leading to tap water mistrust. However, little is known about the broader social, political, and economic drivers of water quality in these settings and how such drivers inform the social construction of risk across different stakeholder groups. Using an underbounded African-American/Hispanic …

Environmental Transmission Of Career Interests Through A Genetic Lens: Understanding The Confounding Around Parental Occupation, Tyler Allan

USF Tampa Graduate Theses and Dissertations

Previous research has established that parents can influence the career interests of their children through both their shared genetics and the household environment they create. However, most studies look at these parental influences in isolation either focusing on the environmental influences or the genetic influences. As such, the results of these studies fail to account for potential confounding in their results do to the nature of career interests. This study used a genetically informative twin sample to address the issue of shared genetics while looking at the measured environmental influence a parent’s occupation has on their child’s career interests. A …

The Evolution Of Honeycomb, Grace Cope

Master of Science in Integrative Biology Theses

The regular cells of honeycomb nests have fascinated scholars and mathematicians for millennia. In 36BC, the Roman scholar Marcus Terentius Varro first proposed the “honeycomb conjecture,” in which he postulated that bees build their comb using hexagons because it is the shape that requires the least amount of material to divide space into equal portions. Since this time, honeycomb has been used by engineers in applications that range from skyscraper supports to impact absorbers inside the feet of the lunar lander during the first moon missions, but mysteries remain about the biological origins of honeycomb and the mechanical properties of …

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling To Promote Health And Longevity, Mahmoud Abdellatif, Tobias Pendl, Sebastian J Hofer, Moydul Islam, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Et Al

2020-Current year OA Pubs

BACKGROUND: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial.

METHODS: We performed a lifelong study to assess cardiac health and lifespan in 2 cardiomyocyte-specific transgenic mouse models with enhanced versus reduced IGF1 receptor (IGF1R) signaling. Male mice with human IGF1R overexpression or dominant negative phosphoinositide 3-kinase mutation were examined at different life stages by echocardiography, invasive hemodynamics, and treadmill coupled to indirect calorimetry. In vitro assays included cardiac histology, mitochondrial respiration, ATP synthesis, autophagic …

Ceramide-1-Phosphate: A Novel Regulator Of Golgi Fragmentation, Golgi-Er Vesicle Trafficking, And Anaplasma Phagocytophilum Pathogenesis, Anika Nayar Ali

USF Tampa Graduate Theses and Dissertations

Anaplasma phagocytophilum, the etiologic agent of human granulocytic anaplasmosis (HGA), is a tick transmitted obligate intracellular bacterium that infects granulocytes, bone marrow progenitor cells and endothelial cells. HGA exhibits symptoms of febrile illness including fever, chills, headache, malaise, leukopenia and elevated liver enzymes which are treatable by antibiotics. However, elderly and immunocompromised patients are at a greater risk of developing fatal complications. Inside the host cell A.phagocytophilum resides in host cell derived vacuole called A.phagocytophilum occupied vacuole (ApV) where it undergoes its biphasic lifecycle. Being an intracellular pathogen, A.phagocytophilum relies heavily on nutrient acquisition from host cell and to obtain …

A Multi-Ethnic Polygenic Risk Score Is Associated With Hypertension Prevalence And Progression Throughout Adulthood, Kerri L Wiggins, Walter Palmas, Kent D Taylor, Henry J Lin, Jeffrey Haessler, Yan Gao, Daichi Shimbo, Jennifer A Smith, Bing Yu, Elena V Feofanova, Roelof A J Smit, Zhe Wang, Shih-Jen Hwang, Simin Liu, Sylvia Wassertheil-Smoller, Joann E Manson, Donald M Lloyd-Jones, Stephen S Rich, Susan Redline, Adolfo Correa, Charles Kooperberg, Myriam Fornage, Robert C Kaplan, Bruce M Psaty, Jerome I Rotter, Donna K Arnett, Alanna C Morrison, Nora Franceschini, Daniel Levy, Tamar Sofer, Nhlbi Trans-Omics In Precision Medicine (Topmed) Consortium

Faculty, Staff and Student Publications

In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across estimated effect sizes from multiple potential PRS using the same GWAS, after which the 3 trait-specific PRSs are combined via an unweighted sum called "PRSsum", forming the HTN-PRS. The HTN-PRS is associated with both prevalent and incident hypertension at 4-6 …

The Flow Of (Re)Memory In African American And Nubian Egyptian Literature: Morrison, Oddoul, And Mukhtar, Bushra Hashem

Theses and Dissertations

The purpose of this thesis is to define the term rememory, which Toni Morrison coins in her novel Beloved, and explore its interplay with water imagery in the novel and in two Nubian short stories, namely Haggag Oddoul’s “The River People” and Yahya Mukhtar’s “The Nile Bride.” The three narratives have core common features: they centralize water bodies as key sites of events, they depend heavily on the retelling of history and mythology, and they are told predominantly from the perspective of women. How do the writers weave rememory, history, and mythology to produce these narratives? Are they attempting to …

Ethical Considerations Concerning The Dignity Of Patients With Terminal Disabling Illness, Hebatallah Rashed

Theses and Dissertations

Almost everyone agrees that they should be treated and treat others in a dignified manner; however, people have different views about dignity and what gives people honour and worth. There are different philosophical ideas about the meaning of this concept and its conditions. The concept of human dignity has been a fundamental yet controversial area in the field of bioethics, especially with the ongoing debate over euthanasia.

The aim of this thesis was to evaluate different philosophical views about the concept of dignity, and how the evolution of this concept throughout history affected our understanding of the moral permissibility of …

Integrated Screens Uncover A Cell Surface Tumor Suppressor Gene Kirrel Involved In Hippo Pathway, Chao Wang, Xu Feng, Dan Su, Zhen Chen, Shimin Wang, Min Huang, Huimin Zhang, Siting Li, Ling Yin, Randy L Johnson, Traver Hart, Junjie Chen

Faculty, Staff and Student Publications

Cell surface proteins play essential roles in various biological processes and are highly related to cancer development. They also serve as important markers for cell identity and targets for pharmacological intervention. Despite their great potentials in biomedical research, comprehensive functional analysis of cell surface proteins remains scarce. Here, with a de novo designed library targeting cell surface proteins, we performed in vivo CRISPR screens to evaluate the effects of cell surface proteins on tumor survival and proliferation. We found that

Mechanism Of Voltage Sensing In Ca2+- And Voltage-Activated K + (Bk) Channels, Willy Carrasquel-Ursulaez, Ignacio Segura, Ignacio Díaz-Franulic, Felipe Echeverría, Yenisleidy Lorenzo-Ceballos, Nicolás Espinoza, Maximiliano Rojas, Jose Antonio Garate, Eduardo Perozo, Osvaldo Alvarez, Fernando D Gonzalez-Nilo, Ramón Latorre, Valeria Marquez-Miranda

2020-Current year OA Pubs

In neurosecretion, allosteric communication between voltage sensors and Ca