Digital Commons Network^™

Role Of Epigenome In Regulation Of Inflammation By Ahr Ligands 2,3,7,8-Tetrachlorodibenzo-P-Dioxin And 6-Formylindolo[3,2-B] Carbazole, Alkeiver Cannon

Theses and Dissertations

Autoimmune Hepatitis (AIH) is a chronic inflammatory disease of the liver mediated by immune cells and characterized by a variety of parameters including circulating autoantigens, elevated immunoglobulin G (IgG) and aminotransferases, and interface hepatitis. Unfortunately, despite treatment with broadly immunosuppressive drugs, the disease progresses to cirrhosis and end-stage liver disease in several cases. In order to develop a more specific treatment, the mechanisms governing the liver injury resulting from inflammation and autoimmunity need to be elucidated.

For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from consideration as a therapeutic approach due to the potential toxic effects of AhR …

Mass Spectrometric Investigation Of Removal/Transformation Of Emerging Contaminants For Safer Potable Wastewater Reuse, Kristin Cochran

Theses and Dissertations

Water scarcity is of increasing global concern as rising demand depletes current sources, so other sources such as potable wastewater reuse are being utilized. Advanced wastewater reuse removes pathogens and many contaminants, but there are concerns about resistant contaminants and the transformation products that are generated during the treatment process. This research focuses on several different contaminant classes, how well they are removed via advanced treatment processes, what transformation products arise from both advanced treatment and chlorination disinfection, and how those treated waters may impact health via toxicity and estrogen activity.

Contaminant classes considered are illicit drugs, pharmaceuticals such as …

The Development Of A Monolithic Spatial Heterodyne Spectrometer For Extreme Environments, Arelis Michelle Colόn

Theses and Dissertations

This work describes improvements to a novel instrument, the monolithic spatial heterodyne Raman spectrometer (mSHRS), which has potential to be utilized in space exploration and deep-ocean marine sensing. In previous work, the spatial heterodyne Raman spectrometer (SHRS) was demonstrated, as a small, high resolution, wide field of view spectrometer, originally developed for space applications where small size and compactness is a key consideration or where a wide field of view is advantageous, such as in remote spectroscopy. The spatial heterodyne spectrometer (SHS) was then later utilized for remote Laser-Induced Breakdown Spectroscopy (LIBS). The high throughput, high spectral resolution, and large …

Evaluation Of Monthly And Seasonal Grazing Rates Of Ilyanassa Obsoleta On Benthic Microalgae In The North Inlet Estuary, Brittany Dearmitt

Theses and Dissertations

The eastern mud snail, Ilyanassa obsoleta, is found at densities of 100’s of individuals m^-2 on soft sediments in the intertidal zones of estuaries. These obligate deposit feeders consume microalgae, detritus, larvae, meiofauna, and macrofauna in the surface layers of sediments with possible trophic impacts on benthic microalgal (BMA) biomass. The goals of this study were to quantify mud snail grazing on BMA biomass, observe the variation in monthly and seasonal grazing rates, and evaluate the relationship between atmospheric temperatures and grazing rates. The sites for this experiment were two mudflats in Oyster Landing, North Inlet estuary, South …

A Novel Cognitive Stress Paradigm To Assess Subtle Cognitive Differences In Women With The Fmr1 Premutation, Jillian Margaret Gierman

Theses and Dissertations

Fragile X premutation (FXPM) is a genetic mutation of the FMR1 gene characterized by having between 55-200 CGG repetitions. FXPM women are at risk for a variety of reproductive, cognitive, and neuropsychiatric deficits, including fragile X-associated primary ovarian insufficiency (FXPOI) and fragile X-associated tremor/ataxia syndrome (FXTAS). FXTAS is a late-onset neurodegenerative disorder characterized by tremor, gait ataxia, cognitive decline, brain atrophy, and deficits in executive functions. With the evidence supporting premature aging, prevalence of cognitive deficits, and risk of developing FXTAS and dementia, it is imperative to find a reliable measure that identifies at-risk FXPM women and their subtle cognitive …

Sensory Processing In Male Children With Fragile X Syndrome And Idiopathic Autism: Implications For Maladaptive Behavior And Within-Syndrome Heterogeneity, Chandler Knott

Theses and Dissertations

Proficient sensory processing affords adaptive responses that are necessary for daily functioning. Atypical sensory processing patterns are common across neurodevelopmental disorders, including autism spectrum disorder (ASD) and fragile X syndrome (FXS), two disorders with a high degree of phenotypic overlap. However, little is known about whether types of atypical sensory processing in FXS vary as a function of genetic etiology or the presence of ASD. Atypical sensory processing has been also associated with maladaptive outcomes in certain clinical populations; however, the impact of these impairments on internalizing and externalizing behavior remains unknown in FXS. Study participants included 37 male children …

Trajectories, Prevention Strategies, And Health Impacts Of Perinatal Depression, Sabrina Karim

Theses and Dissertations

Background

Perinatal depression is one of the most common and underdiagnosed obstetric complications. Extant research on perinatal depression is mostly focused on white women and women who are not at risk for depression. Little is known about the trajectories, prevention strategies and adverse outcomes of perinatal depression among high-risk populations, for example, women with overweight and obesity or women of color or low socioeconomic status.

Purpose

Our study examined the longitudinal trajectories of perinatal depression, effect of a behavioral lifestyle intervention on perinatal depression and association between prenatal physical activity and perinatal depression among women with overweight and obesity. We …

Identifying Novel Pharmacogenetic Markers For Cancer Treatments: Exploiting Cancers Deficient In The Nucleotide Pool Sanitizing Hydrolases Nudt15 And Nudt18, Jacob Chandler Massey

Theses and Dissertations

The NUDIX hydrolases are a super family of enzymes with purported enzymatic activities of nucleotide hydrolases. The activity of the founding member, NUDT1 (also known as MTH1) is established to be a nucleotide hydrolase for d-8-oxoGTP, which is a mutagenic precursor if incorporated into DNA. Therefore, its activity serves to sanitize the nucleotide pool of mutagenic precursors. While known to be highly conserved among all organisms, the enzymatic and biological functions for nearly all the family members remain largely unexplored and unknown. Substrates of family members have been found to include canonical (deoxy)nucleotide triphosphates, oxidized (deoxy)nucleotide triphosphates, and non-nucleoside polyphosphates. …

La Materialidad De Las Vivencias Femeninas: Cuerpos Discapacitados, Prostituidos Y Violados En Las Narrativas Mexicanas Escritas Por Las Mujeres, Hyanghee Lee

Theses and Dissertations

Esta disertación explora los temas específicamente vinculados a las vivencias de las mujeres mexicanas tales como la anormalidad, la discapacidad, la locura, la prostitución, la violencia de género y la madre mutilada que no pueden abordarse sin tener en cuenta el cuerpo femenino. En este proyecto se discuten estas temáticas aplicando el concepto de la corporeidad o la materialidad de las vivencias que experimentan las mujeres en dicho espacio geopolítico manifestadas en cuatro narrativas mexicanas producidas por las mujeres-escritoras en la época contemporánea del final del siglo XX y al comienzo del siglo XXI: Nadie me verá llorar (1999) de …

Impact Of A Novel Marine Algae Supplement On Inflammatory And Immune Response After High-Intensity Exercise, Caroline Sara Vincenty

Theses and Dissertations

INTRODUCTION: High-intensity exercise (HIE) can damage the musculotendon complex and impact the immune response, which may result in post-exercise inflammation and reductions in strength and performance. Sufficient rest and recovery will improve muscular resilience against future damaging bouts, however HIE with minimal durations of rest are common in athletic competitions that facilitate persistent inflammation and immune dysregulation. Marine algae-derived fucoidans (MA) have previously shown promise to mitigate pro-inflammatory and immune dysregulation responses, however it has not been investigated in the context of HIE. The purpose of this research is to investigate the safety and efficacy of MA on markers of …

Mechanisms Of Connectivity In Neuronal Development, Janay Vacharasin

Theses and Dissertations

The development of neuronal connectivity requires the careful orchestration of multiple cellular processes including the control of neuronal arborization and synapse formation or function. Defects in these processes during neuronal development will give rise to disorders of neuronal connectivity like autism. In the present work, we examine the genetic and epigenetic mechanisms that build the neuronal wiring of the developing brain. We use human stem cell-derived neurons to study neuronal arborization and function focusing on genetic and environmental risk factors of neurodevelopmental disorders that include autism and intellectual disability. Specifically, we focused on the contribution of the endomembrane, chromatin, and …

Preparing Trauma Informed Teachers And Utilizing Trauma Responsive Systems To Increase Educational Success For Elementary Age Students, Kate Jordal

School of Education and Leadership Student Capstone Projects

Research suggests that trauma informed teaching practices benefit all students, regardless of whether or not they have experienced trauma. The professional development created for this project is informed by the work of Danielle Theis’ Teach to Heal and Performing Tracking System (2022), Nicholas Long’s Life Space Crisis Intervention (2021), the scholarship of Ross Greene (2014), and the educational framework Universal Design for Learning (2022). Trauma informed teaching practices include at its core: role definition for adults, common language, and explicit teaching of social emotional skills. The professional development will help teachers create a trauma responsive classroom which will be beneficial …

Using An Ecojustice Education Framework To Address Conservation In The Upstate, Rebecca Bolich-Wade

School of Education and Leadership Student Capstone Projects

In an era of complex and overlapping issues, it is critical to evaluate the effectiveness of alternative interdisciplinary methodology within the fields of justice and environmental conservation. One such method is encapsulated in an ecojustice education framework. This capstone project sought to analyze the effectiveness of an ecojustice education framework to address conservation in the Upstate of South Carolina. In the process of this study’s literature review, it is evident that isolating social justice from environmental conservation is ineffective and unresponsive to the needs that historically underserved communities today face in terms of the mitigation of environmental burdens and enhancement …

Renewable Energy Education At Residential Environmental Learning Centers, Kim Corson

School of Education and Leadership Student Capstone Projects

This capstone project sought to answer the question, what are effective methods for teaching middle school students about renewable energy at residential environmental learning centers? Research shows that participation in a residential learning experience helps students retain knowledge and learn in a more hands-on and real world context. However, research connecting a residential environmental learning experience and renewable energy education is limited. This project involved creating a curriculum that utilizes effective methods for teaching and learning about renewable energy with the goal to help grow students energy and environmental literacy. The lesson targets middle school students but can be adapted …

How Can A Non-Personal Interpretive Guide Increase Place Attachment For Visitors, Encourage The Appropriate Development Of Sustainable Community-Based Ecotourism, And Increase Knowledge Of The Desert And Coastal Ecosystems And Migratory Whales Of Baja Mexico?, Mahin Hamilton

School of Education and Leadership Student Capstone Projects

Small ecotour companies run whale-watching tours in remote, protected lagoons of Baja California Sur every winter, as gray whales migrate there to mate and give birth to their young. Often, tourists must drive for hours each way to reach the lagoons for their tour. When tourists get to the small villages that are the base camp for whale watching, their only guides are the boat captains, who do not normally speak English (the main language of tourists in the area). A non-personal interpretive guide would bridge the gap of information, so that tourists learn about the ecology, history, and culture …

Developing An Outdoor Learning Area And Guidebook For The Elementary Grades, Jordyn Kern

School of Education and Leadership Student Capstone Projects

Research has shown that outdoor education has major benefits for school-age children (Yildirim & Akamca, 2017). These benefits include increased academic success, better social-emotional development, better physical development, and better mental and physical health (Suttie, 2018). The guidebook designed for this project focuses on how to increase those five things in children across the country. The goal of the guidebook is to increase outdoor education within classrooms throughout the United States and eventually, the world. The guidebook is geared towards elementary school teachers but can be adapted to fit any grade, time frame, and experience level of the teacher. The …

Growing Environmentally Literate Youth, Kimberly Harding

School of Education and Leadership Student Capstone Projects

Research has demonstrated that the importance of producing environmentally literate youth is becoming a priority around the world Producing environmentally literate youth through E-STEM Garden-based learning practices will not only allow our students to become environmentally literate but also capable, aware, citizens with the 21st Century skills necessary to tackle today and tomorrow’s problems. The curriculum designed for this project focuses on using garden-based STEM practices to increase young students' environmental literacy. The project involved using the Next Generation Science standards, the learning goals of the proposed Michigan Environmental Literacy Plan, as well as the American Society for Engineering Education’s …

Cultivating Student Agency Through The Use Of Authentic Science Practices, John Haug

School of Education and Leadership Student Capstone Projects

This paper examines a needed shift in teaching secondary science students as more states and school districts adopt the Next Generation Science Standards (NGSS) for assessing student skills and knowledge. The eight practices identified by the NGSS offer an opportunity to incorporate authentic science instruction into the classroom. Research supports that students who gain confidence in authentic science practices have a broader and deeper understanding of the nature of science. Research also supports that students who improve authentic practices are more likely to trust scientific findings and be more apt to take action on social and environmental issues. This shift …

Supporting Healthy Identity Development Using Text Selection And Instructional Activities In Secondary Language Arts Classes, Carla Beuning Obleman

School of Education and Leadership Student Capstone Projects

Adolescence is a critical juncture in the process of identity development and has implications for secondary-level students. This project connects the topics of adolescent identity development with literature instruction at the secondary level, investigating the question “How can secondary language arts teachers support healthy identity development in adolescent learners using text selection and instructional activities?” A literature review provides a theoretical basis of adolescent identity development, including foundational theories such as Erik Erikson’s psychosocial development theory and contemporary ideas like Kimberlé Crenshaw’s work on intersectionality. The review provides a framework for understanding how text selection and instructional activities affect adolescent …

A Menu About Me: A Next Generation Science Standards Aligned 9-12 Life Science Curriculum Adapted For Students With Limited Or Interrupted Formal Education, Madeline Carras

School of Education and Leadership Student Capstone Projects

In order to face the challenges of a rapidly changing world, it is imperative that thinkers with diverse backgrounds and perspectives are supported in the development of their scientific skills and voice. However, very few, if any, high school life science curricular resources are available that are specifically adapted with the assets and needs of students with limited or interrupted formal education (SLIFE) in mind. The widely adopted Next Generation Science Standards (NGSS) are uniquely designed to center the learner’s authentic thought process and pre-existing funds of knowledge–a framework which also happens to be aligned with the strengths of SLIFE …

Utilizing A Culturally Relevant Ecology Curriculum To Help Students See Intersections Between Their Scientific And Cultural Identities, Emma Singer

School of Education and Leadership Student Capstone Projects

The purpose of this capstone was to create a two-week long ecology unit for high school biology students rooted in culturally relevant practices. The project sought to answer the question “How can utilizing a culturally relevant ecology curriculum help students see intersections between their scientific and cultural identities?” Data shows that people of color and women are underrepresented within the sciences. Disengagement and lack of interest in the sciences begins in middle and high school, suggesting students feel the material is irrelevant or disconnected from their lives. To address this gap, this project utilized a culturally relevant lens to create …

Electrochemically Induced Amorphous-To-Rock-Salt Phase Transformation In Niobium Oxide Electrode For Li-Ion Batteries, Pete Barnes, Yunxing Zuo, Kiev Dixon, Dewen Hou, Sungsik Lee, Zhiyuan Ma, Justin G. Connell, Hua Zhou, Changjian Deng, Kassiopeia Smith, Eric Gabriel, Yuzi Liu, Olivia O. Maryon, Paul H. Davis, Haoyu Zhu, Yingge Du, Ji Qi, Zhuoying Zhu, Chi Chen, Zihua Zhu, Yadong Zhou, Paul J. Simmonds, Ariel E. Briggs, Darin Schwartz, Shyue Ping Ong, Hui Xiong

Materials Science and Engineering Faculty Publications and Presentations

Intercalation-type metal oxides are promising negative electrode materials for safe rechargeable lithium-ion batteries due to the reduced risk of Li plating at low voltages. Nevertheless, their lower energy and power density along with cycling instability remain bottlenecks for their implementation, especially for fast-charging applications. Here, we report a nanostructured rock-salt Nb₂O₅ electrode formed through an amorphous-to-crystalline transformation during repeated electrochemical cycling with Li⁺. This electrode can reversibly cycle three lithiums per Nb₂O₅, corresponding to a capacity of 269 mAh g⁻¹ at 20 mA g⁻¹, and retains a capacity …

Macomb Dental Society Journal Summer 2022

Journal of the Macomb Dental Society

In the Summer 2022 issue, the reader will find the following feature articles:

• Young Dentists
• MODG Golf Outing
• The Meeting

Also included are regular columns from the President, Executive Director and Editor, as well as news shorts and information on upcoming events.

The Truth About The Truth, Chester Gary Dds, Jd

The New York State Dental Journal

Dentists and patients must question the authority and motivation of purveyors of oral health information

Medication-Related Osteonecrosis Of The Jaw: Important Clinical Considerations, Bard J. Levey Dds, Franklin Garcia-Godoy Ds, Ms, Phd

The New York State Dental Journal

Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition for dental practitioners. Despite the plethora of published literature on this topic, widespread clinical awareness and recognition is still not common as clinicians still do not recognize the common, early presentations of this disease. This has been shown in different studies conducted in different parts of the world.1-4 The present paper highlights the important clinical considerations for practitioners to evaluate.

N Y State Dent J June-July 2022

The New York State Dental Journal

In the June-July 2022 issue, the reader will find the following feature articles:

• The Challenges are Many, but There’s Reason for Optimism
• Medication-Related Osteonecrosis of the Jaw: Important Clinical Considerations
• Retained Third Molars Protect Against Fractures of Mandibular Condylar Region
• Patient Recall in the Informed-Consent Process
• Clinical Report on Restoration of Patient with Immediate Loaded Maxillary Restoration Supported by Zygomatic/Endosseous Implants and Mandibular Prothesis Utilizing Three-implant Solution

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Is Filipino Esl Academic Writing Becoming More Informal?, Abdul Wahid I. Tocalo, Shainah P. Racman, Kyla Nicole Alibai G. Guiamelon, Bainarin M. Mama

PASAA

The observation of informalities in academic writing has become tremendous in recent years, as revealed by a plethora of cross-cultural and diachronic studies. Different users of English have already been explored; however, none has centered on the case of English as a Second Language (henceforth ESL) writers, such as Filipino academic writing scholars, in terms of delineating informalities in their academic writing discourse over time. For this reason, this quantitative study aimed to diachronically analyze informality features in academic writing of Filipino ESL researchers in the applied linguistics field. Using the framework of Hyland and Jiang (2017), a significant association …

Reimagine Fire Science For The Anthropocene, Jacquelyn K. Shuman, Jennifer K. Balch, Rebecca T. Barnes, Philip E. Higuera, Andres Holz, Multiple Additional Authors

Geography Faculty Publications and Presentations

Fire is an integral component of ecosystems globally and a tool that humans have harnessed for millennia. Altered fire regimes are a fundamental cause and consequence of global change, impacting people and the biophysical systems on which they depend. As part of the newly emerging Anthropocene, marked by human-caused climate change and radical changes to ecosystems, fire danger is increasing, and fires are having increasingly devastating impacts on human health, infrastructure, and ecosystem services. Increasing fire danger is a vexing problem that requires deep transdisciplinary, trans-sector, and inclusive partnerships to address. Here, we outline barriers and opportunities in the next …

Potential Impact Of Revised Nci Eligibility Criteria Guidance: Prior Malignancy Exclusion In Breast Cancer Clinical Trials, Matthew Perez, Caitlin C Murphy, Sandi L Pruitt, Sawsan Rashdan, Asal Rahimi, David E Gerber

Faculty, Staff and Student Publications

BACKGROUND: Many individuals with cancer have survived a prior cancer and for this reason may have been excluded from clinical trials. Recent NCI guidance recommends including these individuals, especially when the risk of the prior malignancy interfering with either safety or efficacy endpoints is very low. Using breast cancer as an example, we determined the potential effect this policy change may have on clinical trial accrual.

PATIENTS AND METHODS: We reviewed protocols of NCI-sponsored breast cancer clinical trials activated in 1991 through 2016. We quantified prevalence of prior cancer-related exclusion criteria and assessed the association with trial characteristics using Fisher's …

Cas9/Nickase-Induced Allelic Conversion By Homologous Chromosome-Templated Repair In Drosophila Somatic Cells, Sitara Roy, Sara Sanz Juste, Marketta Sneider, Ankush Auradkar, Carissa Klanseck, Zhiqian Li, Alison Henrique Ferreira Julio, Victor Lopez Del Amo, Ethan Bier, Annabel Guichard

Faculty, Staff and Student Publications

Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template. Here, a