Digital Commons Network^™

Actionable Tumor Alterations And Treatment Protocol Enrollment Of Pediatric And Young Adult Patients With Refractory Cancers In The National Cancer Institute-Children's Oncology Group Pediatric Match Trial, D Williams Parsons, Katherine A Janeway, David R Patton, Cynthia L Winter, Brent Coffey, P Mickey Williams, Sinchita Roy-Chowdhuri, Gregory J Tsongalis, Mark Routbort, Nilsa C Ramirez, Lauren Saguilig, Jin Piao, Todd A Alonzo, Stacey L Berg, Elizabeth Fox, Douglas S Hawkins, Jeffrey S Abrams, Margaret Mooney, Naoko Takebe, James V Tricoli, Nita L Seibel, Nci-Cog Pediatric Match Team

Center for Medical Ethics and Health Policy Staff Publications

Purpose: The National Cancer Institute-Children's Oncology Group Pediatric MATCH trial aimed to facilitate evaluation of molecular-targeted therapies in biomarker-selected cohorts of childhood and young adult patients with cancer by screening tumors for actionable alterations.

Patients and methods: Tumors from patients age 1-21 years with refractory solid tumors, lymphomas, or histiocytic disorders were subjected to cancer gene panel sequencing and limited immunohistochemistry to identify actionable alterations for assignment to phase II treatment arms. The rates of treatment arm assignment and enrollment were compared between clinical and demographic groups.

Results: Testing was completed for 94.7% of tumors submitted. Actionable alterations were detected …

Impact Of Work After Hours On Organizational Commitment Level And Job Satisfaction: A System Dynamics Approach, Mayuri Dilani, Anuja Shukla, Yamini Pandey

Management Dynamics

Work after hours depend on the working conditions of the organization where positive relationship with the organizational commitment and the employee job satisfaction can be seen. Work after hours depend on the working Aim of the study is to recommend a model for the organizational commitment, Job satisfaction and work after hours’ variables for any organization. Vensim 6.4 version and Stella 9.1.4 software packages were used for the analysis. Casual loop analysis was done to identify the interaction of the variables. Model is developed as fully causal loop analysis based on dimensions found in literature and extracted the applicable model. …

Interchromosomal Interaction Of Homologous Stat92e Alleles Regulates Transcriptional Switch During Stem-Cell Differentiation., Matthew Antel, Romir Raj, Madona Y G Masoud, Ziwei Pan, Sheng Li, Barbara G Mellone, Mayu Inaba

Faculty Research 2022

Pairing of homologous chromosomes in somatic cells provides the opportunity of interchromosomal interaction between homologous gene regions. In the Drosophila male germline, the Stat92E gene is highly expressed in a germline stem cell (GSC) and gradually downregulated during the differentiation. Here we show that the pairing of Stat92E is always tight in GSCs and immediately loosened in differentiating daughter cells, gonialblasts (GBs). Disturbance of Stat92E pairing by relocation of one locus to another chromosome or by knockdown of global pairing/anti-pairing factors both result in a failure of Stat92E downregulation, suggesting that the pairing is required for the decline in transcription. …

Heat Stress And The Control Of Skeletal Muscle Mass, Zachary J. Fennel

Health, Exercise, and Sports Sciences ETDs

PURPOSE: 1) Compare the effects of whole-body heat stress (HS) and resistance exercise (RE) on thermoregulatory responses and skeletal muscle heat shock and hypertrophy related signaling. 2) Examine the effects of acute heat stress (HEAT) on myotube growth and fusion compared to controls (CON), hypertrophy (HYPER), and atrophy (RAPA) treatments in-vitro. METHODS: 1) Eight healthy, physically active and resistance trained individuals (18-45 years) completed RE and HS. 2) 48 hours following treatments, C2C12 myotubes were assessed for myotube area and nuclear fusion index. RESULTS: 1) RE and HS similarly increased muscle but not core temperatures. HS but not RE increased …

A Review Of Shiga-Toxin Producing Escherichia Coli (Stec) Contamination In The Raw Pork Production Chain, Manirul Haque, Joseph M. Bosilevac, Byron D. Chaves

Department of Food Science and Technology: Faculty Publications

Epidemiological evidence of Shiga toxin-producing Escherichia coli (STEC) infections associated with the consumption of contaminated pork highlight the need for increased awareness of STEC as an emerging pathogen in the pork supply chain. The objective of this review is to contribute to our understanding of raw pork products as potential carriers of STEC into the food supply. We summarize and critically analyze primary literature reporting the prevalence of STEC in the raw pork production chain. The reported prevalence rate of stx-positive E. coli isolates in live swine, slaughtered swine, and retail pork samples around the world ranged from 4.4 …

The Intersection Of Evolutionary Computation And Explainable Ai, J Bacardit, Aei Brownlee, S Cagnoni, Et Al

School of Engineering, Computing and Mathematics

In the past decade, Explainable Artificial Intelligence (XAI) has attracted a great interest in the research community, motivated by the need for explanations in critical AI applications. Some recent advances in XAI are based on Evolutionary Computation (EC) techniques, such as Genetic Programming. We call this trend EC for XAI. We argue that the full potential of EC methods has not been fully exploited yet in XAI, and call the community for future efforts in this field. Likewise, we find that there is a growing concern in EC regarding the explanation of population-based methods, i.e., their search process and outcomes. …

Hybrid U-Net: Semantic Segmentation Of High-Resolution Satellite Images To Detect War Destruction, Shima Nabiee, Matthew Harding, Jonathan Hersh, Nader Bagherzadeh

Economics Faculty Articles and Research

Destruction caused by violent conflicts play a big role in understanding the dynamics and consequences of conflicts, which is now the focus of a large body of ongoing literature in economics and political science. However, existing data on conflict largely come from news or eyewitness reports, which makes it incomplete, potentially unreliable, and biased for ongoing conflicts. Using satellite images and deep learning techniques, we can automatically extract objective information on violent events. To automate this process, we created a dataset of high-resolution satellite images of Syria and manually annotated the destroyed areas pixel-wise. Then, we used this dataset to …

Multi-Modal Molecular Programs Regulate Melanoma Cell State, Miles C Andrews, Junna Oba, Chang-Jiun Wu, Haifeng Zhu, Tatiana Karpinets, Caitlin A Creasy, Marie-Andrée Forget, Xiaoxing Yu, Xingzhi Song, Xizeng Mao, A Gordon Robertson, Gabriele Romano, Peng Li, Elizabeth M Burton, Yiling Lu, Robert Szczepaniak Sloane, Khalida M Wani, Kunal Rai, Alexander J Lazar, Lauren E Haydu, Matias A Bustos, Jianjun Shen, Yueping Chen, Margaret B Morgan, Jennifer A Wargo, Lawrence N Kwong, Cara L Haymaker, Elizabeth A Grimm, Patrick Hwu, Dave S B Hoon, Jianhua Zhang, Jeffrey E Gershenwald, Michael A Davies, P Andrew Futreal, Chantale Bernatchez, Scott E Woodman

Faculty, Staff and Student Publications

Melanoma cells display distinct intrinsic phenotypic states. Here, we seek to characterize the molecular regulation of these states using multi-omic analyses of whole exome, transcriptome, microRNA, long non-coding RNA and DNA methylation data together with reverse-phase protein array data on a panel of 68 highly annotated early passage melanoma cell lines. We demonstrate that clearly defined cancer cell intrinsic transcriptomic programs are maintained in melanoma cells ex vivo and remain highly conserved within melanoma tumors, are associated with distinct immune features within tumors, and differentially correlate with checkpoint inhibitor and adoptive T cell therapy efficacy. Through integrative analyses we demonstrate …

“Give Me The Rules, I’Ll Understand Grammar Better ”: Exploring The Effectiveness Of Usage-Based Grammar Approach Through Explicit Instruction Of Adverbials, Pouya Vakili

Theses and Dissertations

The main purpose of this dissertation is to examine the (in)effectiveness of the Usage-based grammar approach through explicit instruction of adverbials in the US educational context. One area that can complicate the question of native speakers’ grammar knowledge is their awareness of grammatical terms and their functions. Along with exploring psychological and linguistic domains of language learning and instructional theories and methodologies, and also investigating grammar teaching in US schools, this dissertation intends to examine native speakers’ knowledge of grammar focusing on adverbs and adverbials as its pedagogical concern. Using a limited pool of students to examine the effectiveness of …

"A Breath Of Fresh Air In Congress": A Conversation With Rep. Peter Meijer Of Michigan & Commentary, Ritch K. Eich

The Journal of Values-Based Leadership

No abstract provided.

Essential Instructional Practices For Disciplinary Literacy, Grades 6 To 12, Elizabeth Birr Moje, Darin Stockdill, Rebekah Hornak

Michigan Reading Journal

No abstract provided.

Individual Fluctuations In Blood Lactate Concentration During An Ice Hockey Game; Differences Between Player Positions, Nestor Lögdal, Marko S. Laaksonen, Erik P. Andersson

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 985-993, 2022. The main purpose of the current study was to provide an in-depth description of individual player’s intra-game physiological responses during an ice hockey game. A secondary aim was to compare these responses between forwards and defensemen. Six elite junior ice hockey players, three forwards and three defensemen, median (interquartile range) 17 (17–17) years, 182 (180–185) cm, and 78 (74– 80) kg were recruited to participate in the study. Capillary blood samples were taken following each shift and analyzed for blood lactate concentration (BLC). Heart rate (HR) was registered continuously throughout the game. …

Relationships Between Lower-Body Power, Sprint And Change Of Direction Speed Among Collegiate Basketball Players By Sex, Javier A. Zaragoza, Quincy R. Johson, Daniel J. Lawson, Elizabeth L. Alfaro, J. Jay Dawes, Doug B. Smith

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 974-984, 2022. The purpose of this study was to determine if significant relationships exist between absolute and relative lower-body power and selected measures of speed among male and female collegiate basketball players. Archived performance testing data from 29 (male = 14; female = 15) NCAA division II collegiate basketball players were used for this analysis. These measures included lane agility, 10-yard sprint, and shuttle run time (sec). A Pearson’s correlation coefficient was used to determine if significant relationships existed between measures of lower-body power and linear sprint time, change of direction speed (CODS), and …

Sex Differences In The Glycemic Response To Structured Exercise Interventions In Type Ii Diabetes Mellitus Adults: A Systematic Review, Amaya Prat-Luri, Alejandro Lopez-Valenciano, Elena Sarabia-Cachadiña, Gary Liguori, Francisco Ayala

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 948-961, 2022. Despite physiological sex differences in the prevalence, pathogenesis, and responses to pharmacologic therapies of glucose metabolism in type 2 diabetes mellitus (T2DM) and the current evidence regarding the benefits of physical activity in people with T2DM, there is still a lack of information about the response to physical activity in T2DM depending on the sex. Thus, the aim of the present systematic review was to analyze the physiological sex differences response to physical activity programs in adults with T2DM. A systematic review following PRISMA guidelines was performed up to 4^th January …

Acute Low-Dose Capsiate Supplementation Improves Upper Body Resistance Exercise Performance In Trained Men: A Randomized, Crossover And Double-Blind Study, Helton Pereira Dos Santos Nunes De Moura, Jason Michael Cholewa, Ralf Jaeger, Eduardo Zapaterra Campos, Bruno Viana Rosa, Flavio Antônio De Sousa Nunes, Clara Clara Andressa De Araújo Barros, Priscila Almeida Queiroz Rossi, Jose Gerosa-Neto, Nelo E. Zanchi, Fabricio Eduardo Rossi

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 1007-1018, 2022. Objectives: The purpose of this study was to compare the effects of two acute doses of Capsiate (CAP; 6 vs. 12 mg) on upper body resistance exercise performance in trained men. Methods: Using a randomized, crossover and double-blind design, 20 resistance-trained males were supplemented with low-dose CAP (6 mg), high-dose CAP (12 mg) or placebo 45 minutes before exercise. Subjects performed 4 sets of bench press with repetitions to failure at 70% 1 repetition maximum (1RM) and 2 minutes of rest between each set. The ratings of perceived exertion (RPE) and blood …

Performance Of Upflow Anaerobic Sludge Blanket Reactor With Trickling Filter In Poorly Managed Sewer Network, Rahel Sintayehu Tessema

International Congress on Environmental Modelling and Software

Due to increased water consumption and pressing environmental requirements of the sewage treatment plant, there is a growing attention in urban area of developing country. Given poorly planned, design and management practice of sewerage infrastructure in developing countries, the performance of well-known biological wastewater treatment options worth to evaluate considering operational and maintenance guidelines. This study aimed at evaluating the operational efficiency of Upflow Anaerobic Sludge Blanket (UASB) reactor with Trickling filter (TF) in the presence of recirculating sludge in treating domestic sewage where the sewer network is poorly managed. The case study performed on Kality wastewater treatment plant in …

Assessing The Groundwater Vulnerability To Nitrates And Pesticides Within The Geospatial Decision Support System Landsupport, Marialaura Bancheri, Alessia Perego, Giuliano Langella, Daniele Lezzi

International Congress on Environmental Modelling and Software

This work presents how to assess the groundwater vulnerability to both pesticides and nitrate within the geospatial Decision Support system (s-DSS) of LandSupport, though two new web-based, freely-available dynamical tools, named the pesticide fate tool and nitrate fate tool. The pesticide fate tool is based on the extended transfer function model (TFM-ext), specifically expanded to consider the transport of reactive solutes, i.e., pesticides. The nitrate fate tool is based on the coupling of the ARMOSA model, used to simulate the crop growth dynamics and the consequent nitrate leaching within the most biological active zone (i.e. the rooting depth of the …

Using Slow Sand Filter For Organic Matter And Suspended Solids Removal As Post Treatment Unit For Wastewater Effluent, Samir Addisu Afifi, Amany A. Elfari, Samir Alnahhal

International Congress on Environmental Modelling and Software

The Gaza Strip - Palestine, like any other section of the Mediterranean, has a distinct and substantial water shortage; nevertheless, the problem in this area is more obvious and serious, and it is linked to water quantity and quality. The Gaza Strip's only source of water is groundwater, and agriculture consumes more than 70% of all groundwater extracted. New work has begun to develop sustainable technical and economical solutions to cope with the non-sufficient existing wastewater treatment plant effluents' quality for reuse. The paper evaluated the organic matter and suspended solids removal efficacy of Slow Sand Filter (SSF) designed to …

Successful Use Of Photodynamic Therapy In A Patients With Squamous Cell Carcinoma Of The Lung And Diffuse Endobronchial Lesions, Ghanshyam Mudigonda, Udhayvir Grewal, David Chambers, Kavitha Beedupalli

Journal of Community Hospital Internal Medicine Perspectives

Field cancerization, a phenomenon in which multiple tumors arise in a carcinogen damaged field could potentially explain the synchronous and metachronous premalignant or malignant lesions surrounding the primary tumor in smokers with aerodigestive malignancies. We report the case of a patient with invasive squamous cell carcinoma (SqCC) of the lung, complicated by multiple synchronous, radiologically silent endobronchial lesions. He underwent successful treatment with stereotactic body radiation therapy (SBRT) followed by adjuvant photodynamic therapy (PDT). We wish to highlight the need for more prospective clinical studies to determine which patient population would be appropriate for early bronchoscopic evaluation and the efficacy …

Hereditary Angioedema Presenting As Isolated Jejunal Swelling, Rizwan Ishtiaq, Jerome Gnanaraj, Ché Matthew Harris, Susrutha Kotwal, Waseem Khaliq

Journal of Community Hospital Internal Medicine Perspectives

Hereditary Angioedema (HAE) is a rare disorder caused by C1 esterase inhibitor deficiency or dysfunction. Patients with HAE usually present without urticaria or pruritis affecting the skin, upper airway, or the gastrointestinal tract. They can also present with involvement of unusual sites making the diagnosis challenging and leading to unnecessary testing and complications. Prompt diagnosis and treatment is crucial to prevent mortality and morbidity associated with acute flare. Here we present, what is believed to be second case of isolated involvement of the jejunum from an attack of HAE.

Extracorporeal Liver Support: An Updated Review Of Mechanisms And Current Literature, Anthony Nguyen, Samir Mirza, Nismat Javed, Hamza Hanif, Moon Ryu, Rida Tariq Mirza, Abu Baker Sheikh

Journal of Community Hospital Internal Medicine Perspectives

Introduction: Acute liver failure is a cause of major mortality in the United States. Although the liver possesses regenerative capabilities, liver transplantation is the mainstay of treating acute liver failure. This modality is associated with many financial and logistic challenges. In this regard, Extracorporeal Liver Support (ECLS) might help in reducing mortality as well as bridge a patient to liver transplant. In some cases, the sequelae of liver failure such as hepatic encephalopathy and multi-organ failure can be postponed long enough for the native liver to self-recover function. With this rationale, we sought to describe the mechanism of various ECLS …

Split Dosage Weekly Regimen Of Oral Methotrexate Is Associated With Improved Side Effect Profile In Rheumatoid Arthritis Patients: A Quasi-Experimental Study., Muhammad Sohaib Asghar, Karan Kumar, Sadia Iqbal, - Sagar, Om Parkash, Sumeet Kumar, Manjeet Singh, Rumael Jawed, Mohammed Akram, Farah Yasmin, Muhammad Junaid Tahir, Iftekhar Ahmed, Zohaib Yousaf

Journal of Community Hospital Internal Medicine Perspectives

Background and objectives Methotrexate (MTX) is globally used by physicians to treat patients with Rheumatoid Arthritis (RA). Previously conducted researches indicate prevalent side effects associated with conventional once-weekly dosage amongst a population sample of patients consuming MTX. The objectives of our study were to find out whether there is a difference between the two studied regimens in efficacy and adverse effects of methotrexate. Materials and methods Study participants were recruited from the outpatient rheumatology department after ethical approval and informed patient consent. Disease activity was assessed at baseline with various reliable and validated scales (SDAI, PAS, DAS-28 among others) after …

Analisis Sewa Rahim (Surrogate Mother) Menurut Hukum Perdata Dan Hukum Islam, Adinda Akhsanal Viqria

"Dharmasisya” Jurnal Program Magister Hukum FHUI

Abstract

Uterus rent (Surrogate Mother) appeared due to the process of modernization, But due to the process of renting the uterus then problems arose in the field of law and religion. From the problems that arise due to the practice of renting the uterus, it is necessary to study that discusses the rental of the uterus according to Islamic law. Problems in this study are the reasons that are allowed or not allowed to perform uterine lease as well as the legal status of children born through uterine lease according to Islamic law. The results of research and discussion show …

Boletín Divulgativo Taller: Tratamiento Y Evaluación De La Calidad Del Agua Superficial (Río Magdalena, Girardot Cundinamarca), John Jairo Sandoval Valencia, María Aldaya Rodríguez, Dalia Xiomara Suarez Pulido, Diana Carolina Molina León, Jack Fran Armengot García Pérez, Hernán Darío Fontecha Tarazona

Boletín divulgativo

El siguiente documento presenta los resultados obtenidos en el taller: Tratamiento y evaluación de la calidad de agua superficial (río Magdalena – Girardot, Cundinamarca) realizado en el año 2019, para lo cual se dispusieron los recursos técnicos, logísticos y académicos derivados del proyecto Validación de técnicas analíticas (Volumétricas, Electrodos Selectivos y de Espectroscopia Visible) para el análisis de aguas de la región del Alto Magdalena, encaminando las actividades desarrolladas al entendimiento del manejo adecuado del recurso agua, así como al aprendizaje de diferentes procesos para el manejo y conservación de uno de los principales afluentes de nuestro país.

Medical School Watercooler Newsletter - July 8, 2022, Lindsey Lyle

Watercooler Newsletter

This is the July 8, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Mental health conference and community talk to feature Temple Grandin on July 29
• Research presentations explore genomic instability in cancer
• Calling all alumni: Send us your photos
• Meet a Med Student: Elizabeth Statham
• Pathology announces winners of Allan Tucker Pathology Resident Research Forum

Visualizing Depressive Symptom Improvement: Implementing The 17-Item Hamilton Depression Rating Scale, Briana Raterman

Dissertations

Visualizing Depressive Symptom Improvement: Implementing the 17-Item Hamilton Depression Rating Scale

Abstract

Problem

Depression, a mental health diagnosis, has affected about 18.5% of adults (Villarroel & Terlizzi, 2020). Ketamine, a medication initially used as an anesthetic, has improved depressive symptoms in individuals struggling with treatment-resistant depression.

Method

This quality improvement (QI) project used the 17-item Hamilton Depression Rating Scale questionnaire to assess depressive symptom changes in patients receiving intramuscular ketamine for treatment-resistant depression. The questionnaire was administered to patients pre-and post-intramuscular ketamine administration. The data was collected on injections one, three, and six on each participant’s set schedule of injections …

Bee Brains: Dissecting Pollinator Behavior And The Importance Of Plasticity In The Face Of Changing Environments, Rachel Brant

Dissertations

All organisms face environmental variability, and much of contemporary biological research aims to understand the mechanisms allowing organisms to adapt and survive in the face of change. Animals residing in urban habitats face particularly high levels of unpredictability and environmental fluctuation due to changes based upon human desire. Though urban areas are considered relatively novel habitats, numerous species have adapted to city life, mediated through behavioral and physiological plasticity. Native bee species show particularly high species richness and abundance in urban settings, but the mechanisms driving this pattern are poorly understood. In this dissertation, I explore how bees employ plasticity …

Reducing Pediatric Morbidity Through Development Of A Clinical Practice Guideline, Deanna Kroh

Dissertations

Peripheral intravenous therapy is a commonly utilized treatment modality for the care of acutely ill pediatric patients. Two risk factors include infiltration and extravasation injuries. These injuries, peripheral intravenous infiltration or extravasation injuries (PIVIEs), can vary in their clinical manifestations from minor discomfort to harm as severe as loss of limb or disfigurement. Clinicians caring for patients at risk of developing PIVIEs need to be able to act quickly to reduce potential morbidity. The purpose of this project was to create a clinical practice guideline (CPG) that would guide staff intervention if a PIVIE occurs, with the ultimate goal of …

Education To Improve Long-Acting Injectable Antipsychotic Use, Travis Donald Wolfangel

Dissertations

Purpose: Long-acting injectable (LAI) antipsychotics are underutilized as an evidence-based treatment for schizophrenia and schizoaffective disorder. The purpose of this quality improvement project was to determine if a web-based LAI education module changed advance practice prescribers’ knowledge, attitudes, and practice behaviors regarding LAI antipsychotics one month after receiving LAI education at a community-based mental health organization.

Methods: This QI project was an observational pre- post-educational design. The 20-item Knowledge, Attitudes, and Practices (KAP) questionnaire was used to assess advanced practice providers’ knowledge retention, attitude changes, and practice modifications regarding LAI antipsychotics and prospective patient chart reviews were performed. …

Sex Differences In The Behavioural Outcomes Of Prenatal Nicotine And Tobacco Exposure, Anita Sikic, Jude A. Frie, Jibran Y. Khokhar, Jennifer E. Murray

Neuroscience Institute Publications

Smoking remains the leading cause of preventable death worldwide. A combination of biological and environmental risk factors make women especially vulnerable to nicotine addiction, making it harder for them to quit smoking. Smoking during pregnancy, therefore, is still a major health concern, with epidemiological data suggesting a role for gestational nicotine exposure in the development of several behavioural disorders. Given there are significant sex-specific behavioural outcomes related to smoking in adolescence and adulthood, it is probable that the behavioural outcomes following gestational nicotine or tobacco exposure are similarly sex-dependent. This is an especially relevant topic as the current landscape of …