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2022

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Utilizing The Potentials Of Big Data In Library Environments In Nigerian For Recommender Services, Job Onekutu Sani, Nneka Angela Oseji Jan 2022

Utilizing The Potentials Of Big Data In Library Environments In Nigerian For Recommender Services, Job Onekutu Sani, Nneka Angela Oseji

Library Philosophy and Practice (e-journal)

The big data revolution has gained global attention and initiated creative innovations in every field and libraries as engines of access to information have also been affected by this new trend. Libraries in this part of the world have not utilized the amazing potential of big data in library services. In this time, when various terms such as algorithms age, petabytes age, data age, etc. are been used to describe the activities initiated by machine learning, industries and organizations can achieve much by incorporating inspiring and innovative tools to improve services and performance. In this vein libraries in Nigeria are …


Investigation Of The Users’ Access To Health Information For Sustainable Development During The Covid 19 Era In Professor Kenneth Dike E-Central Library, Awka, Anambra State, Eliezer C. Agim, Maureen Azolo Jan 2022

Investigation Of The Users’ Access To Health Information For Sustainable Development During The Covid 19 Era In Professor Kenneth Dike E-Central Library, Awka, Anambra State, Eliezer C. Agim, Maureen Azolo

Library Philosophy and Practice (e-journal)

The research investigated users’ access to health information for sustainable development during the Covid 19 era in Professor Kenneth Dike E-central Library, Awka, Anambra state. A descriptive survey research design was used for the study. The sample population comprised of 100 users of Professor Kenneth Dike E-central Library through the use of accidental sampling technique. A structured questionnaire was used for collection of data. The instrument was subjected to face validation and pilot test using Cronbach Alpha which gave a reliability coefficient value of 0.97. Data collected from the study were analyzed using mean scores. The study found that health …


Perceived Impact Of Contemporary Library Technology On Academic Performance Of Distance Education Undergraduates Of Universities In Nigeria, Lucynda Uzoamaka Koledoye Ph.D, Justina Ngozi Igwe Ph.D Jan 2022

Perceived Impact Of Contemporary Library Technology On Academic Performance Of Distance Education Undergraduates Of Universities In Nigeria, Lucynda Uzoamaka Koledoye Ph.D, Justina Ngozi Igwe Ph.D

Library Philosophy and Practice (e-journal)

The study looked at the impact of library technology on the academic performance of Nigerian university distance education undergraduates. A descriptive survey design was used in this investigation. The study was based on two research topics. The survey included 698 participants from Nigeria's recognized universities. Because the study's population size can be controlled, there was no need for sampling. The data collection instrument was a 39-item structured questionnaire produced by the researchers titled: Library technology on Academic Performance of Distance Education Questionnaire (TAPDEQ). Three specialists from the University of Nigeria, Nsukka's Faculty of Education verified the instrument. The instrument's internal …


The Use Of Personal Digital Archiving For Effective Learning During Pandemic Covid-19, Naufal Ahmad Rijalul Alam Jan 2022

The Use Of Personal Digital Archiving For Effective Learning During Pandemic Covid-19, Naufal Ahmad Rijalul Alam

Library Philosophy and Practice (e-journal)

The Covid 19 pandemic that ravaged the world, particularly Indonesia, had a negative impact on aspects of learning, particularly for children aged three to six years in early childhood education. The implementation of distance learning disrupted the face-to-face learning model, which was supposed to be the primary medium for increasing children's knowledge and interest. In this regard, the role of parents is critical in ensuring that learning at home is effective and enjoyable. This study explores the using personal digital archiving (PDA) conducted by parents for effective learning during pandemic covid-19. By using a case study, this qualitative research took …


Design And Development Research: Prototyping In Web Opac For Indonesian Children, Rifa Nadila, Riche Cynthia Johan, Gema Rullyana Jan 2022

Design And Development Research: Prototyping In Web Opac For Indonesian Children, Rifa Nadila, Riche Cynthia Johan, Gema Rullyana

Library Philosophy and Practice (e-journal)

As a searching tool for bibliography sources in libraries, OPAC should provide convenience to meet the users’ information needs, with notes that every user has different needs and characteristics. OPAC at large libraries in Indonesia, including the National Library of Republic Indonesia, is designed without adjusting children’s ability and is mostly used for adults. The need for children’s OPAC development in Indonesia and children’s unique characteristics in searching strategies is defined as problem backgrounds. Therefore, this study aims to develop a simple search OPAC in simulated prototype form. The Design and Development method is used by adapting stages of the …


Pupils’ Experience With E-Learning During Covid-19 Lockdown In Delta State., Gloria Ogheneghatowho Oyovwe-Tinuoye Dr, Esharenana E. Adomi Prof Jan 2022

Pupils’ Experience With E-Learning During Covid-19 Lockdown In Delta State., Gloria Ogheneghatowho Oyovwe-Tinuoye Dr, Esharenana E. Adomi Prof

Library Philosophy and Practice (e-journal)

This study scrutinised pupils’ experience with e-learning during COVID-19 lockdown in Delta State. The study adopted a descriptive survey research design with five (5) research objectives of the study. The questionnaire was constructed after consultation of related literature to ensure that pertinent items were encompassed in it. A self-constructed questionnaire entitled “Pupils Experience with E-Learning during COVID- 19 Lockdown Questionnaire (PEELDC19LQ) was designed by the researchers. The population of the study comprised of all pupils in Delta State who participated in e-learning to meet up with the third curriculum and eventually used for promotion for the next class. The researchers …


User Perception Of The Use Of Integrated Library Softwares For Service Delivery In Federal University Libraries In The Niger Delta, Nigeria, Gloria Ogheneghatowho Oyovwe-Tinuoye Dr, Ademola Ferdinand Omosekejimi Mr Jan 2022

User Perception Of The Use Of Integrated Library Softwares For Service Delivery In Federal University Libraries In The Niger Delta, Nigeria, Gloria Ogheneghatowho Oyovwe-Tinuoye Dr, Ademola Ferdinand Omosekejimi Mr

Library Philosophy and Practice (e-journal)

Like many countries, Nigeria’s university library services are affected by the integrated software used for service delivery. This study (conducted in 2021) examined the priorities and barriers for users perception of the use of integrated library software for service delivery in federal university libraries in the Niger Delta, Nigeria and the type of integrated software used by the Federal university libraries in Niger Delta, Nigeria, including what type of services rendered with the use of integrated library software to users, ease of use of integrated library software and benefit derived from the use and factors affecting the use were evaluated. …


Comparative Study For Assessment Of Koha And Slims Features In Public Sector College Libraries Of Sindh, Aijaz Akhter Ahmedani, Khurram Shahzad, Rashid Siddique, Sara Khan Jan 2022

Comparative Study For Assessment Of Koha And Slims Features In Public Sector College Libraries Of Sindh, Aijaz Akhter Ahmedani, Khurram Shahzad, Rashid Siddique, Sara Khan

Library Philosophy and Practice (e-journal)

The core aim of the study was to assess KOHA and SLiMS features in Government College Libraries of Sindh. The objectives of the study were (a) to explore the reasons of Koha and SLiMS adoption and (b) to recognize the problems face by library professionals in the implementation of Koha and SLiMS. To meet the objectives, the study used a quantitative research approach and the survey method based on the questionnaire. Purposive sampling technique was used. The data was gathered only from those librarians who were working in Govt Colleges of Karachi, Hyderabad, and Sukkur and were using Koha or …


Physical Work Environment And Job Satisfaction Of Library Personnel In Academic Libraries In Ogun State, Nigeria, Omolara Olufunmilayo Akinlade, Fredrick O. Ajegbomogun, Nancy Okorie Ph.D Jan 2022

Physical Work Environment And Job Satisfaction Of Library Personnel In Academic Libraries In Ogun State, Nigeria, Omolara Olufunmilayo Akinlade, Fredrick O. Ajegbomogun, Nancy Okorie Ph.D

Library Philosophy and Practice (e-journal)

Employee's job satisfaction is one of the primary factors that has been connected to the success of any organization. As a result, elements like promotions, remuneration, proper training, leadership styles, nature of work, perceived fairness and equality, coworker, and work environment all contribute to library personnel's job satisfaction. This study examined the influence of physical work environment on job satisfaction of library personnel in academic libraries in Ogun state, Nigeria. The population for this study includes the library personnel of nine academic libraries. Multistage sampling technique was used to select 170 respondents from nine academic libraries in Ogun State. Frequency …


Availability And Accessibility As Determinants Of Use Of Electronic Reference Sources Among Secondary School Teachers In Ekiti State Nigeria, Adesanmi Mathew Farukuoye, Olayinka Folorunso, Elizabeth Bukunola Lateef Jan 2022

Availability And Accessibility As Determinants Of Use Of Electronic Reference Sources Among Secondary School Teachers In Ekiti State Nigeria, Adesanmi Mathew Farukuoye, Olayinka Folorunso, Elizabeth Bukunola Lateef

Library Philosophy and Practice (e-journal)

Abstract

Availability of information resources plays a major role in teaching and learning. For effective teaching to take place information resources must be provided and teachers must have access to various types of resources particularly in their areas of specialization. This will not only broaden their knowledge base but also prepare them ahead of the challenges that may face them in the course of imparting knowledge. A variety of activities that are performed by teachers in the course of carrying out their professional duties is hinged on close interaction with the various reference sources in their areas of specialization. These …


Measuring The Reliability Analysis Of University Students' Utilization Of Web-Based Library And Information Services In Malaysian Academic Libraries, Husain Hashim, Shamila Mohamed Shuhidan, Norizan Anwar Jan 2022

Measuring The Reliability Analysis Of University Students' Utilization Of Web-Based Library And Information Services In Malaysian Academic Libraries, Husain Hashim, Shamila Mohamed Shuhidan, Norizan Anwar

Library Philosophy and Practice (e-journal)

The purpose of this article is to examine a small sample of data looking at the extent to which the utilization of web-based library and information services has any relationship with library technology, the roles of academic libraries, and the library learning environment. In addition, a moderating variable is introduced, namely, information literacy skills, to investigate its influence on the correlation between library technology and library learning environment factors, and the utilization of web-based library and information services. The sample is designed to involve students at public Malaysian universities. Based on a review of the literature, a 47-item questionnaire was …


Library Services Provision And Satisfaction: A Case Study Of Postgraduate Students In Universities In South-West, Nigeria, Ayotola Olubunmi Onanuga, Halimah Odunayo Amuda, Olufemi Olubunmi Ilori Jan 2022

Library Services Provision And Satisfaction: A Case Study Of Postgraduate Students In Universities In South-West, Nigeria, Ayotola Olubunmi Onanuga, Halimah Odunayo Amuda, Olufemi Olubunmi Ilori

Library Philosophy and Practice (e-journal)

This study examined the sources of information, services rendered in the library, ascertain the level of satisfaction and the correlation between library services provision and satisfaction. It has been observed that postgraduate students hardly patronise the library though some of the underlying causes of this low patronage have been documented, yet there were no sufficient explanations as to whether these causes affected their level of satisfaction. Thus, it has become necessary to empirically establish the aforementioned and this necessitates a need for this study. This study adopted a survey research method with target population of all postgraduate students in selected …


Does Librarian Job Satisfaction Mediate The Relationship Between Librarian Leadership Styles, Library Culture And Employees Commitment?, Tahammul Shah, Naveed Saif, Imrab Shaheen, Naseeb Ullah Jan 2022

Does Librarian Job Satisfaction Mediate The Relationship Between Librarian Leadership Styles, Library Culture And Employees Commitment?, Tahammul Shah, Naveed Saif, Imrab Shaheen, Naseeb Ullah

Library Philosophy and Practice (e-journal)

The current study tries to align various model of mediation through leadership styles (Transformational, Transactional), organization culture types (innovative, supportive and bureaucratic) with employee’s commitment thorough job satisfaction among the employees of government libraries from Khyber pakhtoonKhwa Pakistan. The data was collected through adopted construct from finite sample and it was analyzed through (Barron and Kenny) meditational procedure. Findings depict that employees commitment with job depend upon the leadership styles and it is positively mediated by their satisfaction from job. In contrast from three different cultural set up only bureaucratic cultural attribute shows significant relationship with employee’s commitment through meditational …


Increased Virus Dissemination Leads To Enhanced Lung Injury But Not Inflammation During Influenza-Associated Secondary Bacterial Infection, Amanda P Smith, Lindey C Lane, Ivan Ramirez Zuniga, David M Moquin, Peter Vogel, Amber M Smith Jan 2022

Increased Virus Dissemination Leads To Enhanced Lung Injury But Not Inflammation During Influenza-Associated Secondary Bacterial Infection, Amanda P Smith, Lindey C Lane, Ivan Ramirez Zuniga, David M Moquin, Peter Vogel, Amber M Smith

2020-Current year OA Pubs

Secondary bacterial infections increase influenza-related morbidity and mortality, particularly if acquired after 5-7 d from the viral onset. Synergistic host responses and direct pathogen-pathogen interactions are thought to lead to a state of hyperinflammation, but the kinetics of the lung pathology have not yet been detailed, and identifying the contribution of different mechanisms to disease is difficult because these may change over time. To address this gap, we examined host-pathogen and lung pathology dynamics following a secondary bacterial infection initiated at different time points after influenza within a murine model. We then used a mathematical approach to quantify the increased …


It Is Time To Define An Organizational Model For The Prevention And Management Of Infections Along The Surgical Pathway: A Worldwide Cross-Sectional Survey, Massimo Sartellli, John E. Mazuski, Et Al. Jan 2022

It Is Time To Define An Organizational Model For The Prevention And Management Of Infections Along The Surgical Pathway: A Worldwide Cross-Sectional Survey, Massimo Sartellli, John E. Mazuski, Et Al.

2020-Current year OA Pubs

No abstract provided.


Mega-Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Jennifer Harper, Michael Myers, Michael T Perino, Qiongru Yu, Chad M Sylvester, Et Al. Jan 2022

Mega-Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Jennifer Harper, Michael Myers, Michael T Perino, Qiongru Yu, Chad M Sylvester, Et Al.

2020-Current year OA Pubs

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as …


The Enigma Stroke Recovery Working Group: Big Data Neuroimaging To Study Brain-Behavior Relationships After Stroke, Sook-Lei Liew, Catherine E Lang, Anup K Bhattacharya, Et Al. Jan 2022

The Enigma Stroke Recovery Working Group: Big Data Neuroimaging To Study Brain-Behavior Relationships After Stroke, Sook-Lei Liew, Catherine E Lang, Anup K Bhattacharya, Et Al.

2020-Current year OA Pubs

The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data …


Animal Source Foods, Rich In Essential Amino Acids, Are Important For Linear Growth And Development Of Young Children In Low- And Middle-Income Countries, Panam Parikh, Richard Semba, Mark Manary, Sumathi Swaminathan, Emorn Udomkesmalee, Rolf Bos, Bee Koon Poh, Nipa Rojroongwasinkul, Jan Geurts, Rini Sekartini, Tran Thuy Nga Jan 2022

Animal Source Foods, Rich In Essential Amino Acids, Are Important For Linear Growth And Development Of Young Children In Low- And Middle-Income Countries, Panam Parikh, Richard Semba, Mark Manary, Sumathi Swaminathan, Emorn Udomkesmalee, Rolf Bos, Bee Koon Poh, Nipa Rojroongwasinkul, Jan Geurts, Rini Sekartini, Tran Thuy Nga

2020-Current year OA Pubs

Growth faltering under 5 years of age is unacceptably high worldwide, and even more children, while not stunted, fail to reach their growth potential. The time between conception and 2 years of age is critical for development. The period from 6 to 23 months, when complementary foods are introduced, coincides with a time when growth faltering and delayed neurocognitive developments are most common. Fortunately, this is also the period when diet exercises its greatest influence. Growing up in an adverse environment, with a deficient diet, as typically seen in low- and middle-income countries (LMICs), hampers growth and development of children …


Developing Real-World Evidence From Real-World Data: Transforming Raw Data Into Analytical Datasets, Lisa Bastarache, Jeffrey S Brown, James J Cimino, David A Dorr, Peter J Embi, Philip R O Payne, Adam B Wilcox, Mark G Weiner Jan 2022

Developing Real-World Evidence From Real-World Data: Transforming Raw Data Into Analytical Datasets, Lisa Bastarache, Jeffrey S Brown, James J Cimino, David A Dorr, Peter J Embi, Philip R O Payne, Adam B Wilcox, Mark G Weiner

2020-Current year OA Pubs

Development of evidence-based practice requires practice-based evidence, which can be acquired through analysis of real-world data from electronic health records (EHRs). The EHR contains volumes of information about patients-physical measurements, diagnoses, exposures, and markers of health behavior-that can be used to create algorithms for risk stratification or to gain insight into associations between exposures, interventions, and outcomes. But to transform real-world data into reliable real-world evidence, one must not only choose the correct analytical methods but also have an understanding of the quality, detail, provenance, and organization of the underlying source data and address the differences in these characteristics across …


A Phase 1b Study Of Telisotuzumab Vedotin In Combination With Nivolumab In Patients With Nsclc, D Ross Camidge, Daniel Morgensztern, Et Al. Jan 2022

A Phase 1b Study Of Telisotuzumab Vedotin In Combination With Nivolumab In Patients With Nsclc, D Ross Camidge, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Telisotuzumab vedotin (Teliso-V) is an anti-c-Met-directed antibody-drug conjugate that has exhibited antitumor activity as monotherapy in NSCLC. Its potential activity combined with programmed cell death protein-1 inhibitors has not been previously evaluated.

METHODS: In a phase 1b study (NCT02099058), adult patients (≥18 y) with advanced NSCLC received combination therapy with Teliso-V (1.6, 1.9, or 2.2 mg/kg, every 2 wk) plus nivolumab (3 mg/kg, 240 mg, or per locally approved label). The primary objective was to assess safety and tolerability; secondary objectives included the evaluation of antitumor activity.

RESULTS: As of January 2020, a total of 37 patients received treatment …


A Map Of Neurofilament Light Chain Species In Brain And Cerebrospinal Fluid And Alterations In Alzheimer's Disease, Melissa M Budelier, Yingxin He, Nicolas R Barthelemy, Hong Jiang, Yan Li, Ethan Park, Rachel L Henson, Suzanne E Schindler, David M Holtzman, Randall J Bateman Jan 2022

A Map Of Neurofilament Light Chain Species In Brain And Cerebrospinal Fluid And Alterations In Alzheimer's Disease, Melissa M Budelier, Yingxin He, Nicolas R Barthelemy, Hong Jiang, Yan Li, Ethan Park, Rachel L Henson, Suzanne E Schindler, David M Holtzman, Randall J Bateman

2020-Current year OA Pubs

Neurofilament light is a well-established marker of both acute and chronic neuronal damage and is increased in multiple neurodegenerative diseases. However, the protein is not well characterized in brain tissue or body fluids, and it is unknown what neurofilament light species are detected by commercial assays and whether additional species exist. We developed an immunoprecipitation-mass spectrometry assay using custom antibodies targeting various neurofilament light domains, including antibodies targeting Coil 1A/1B of the rod domain (HJ30.13), Coil 2B of the rod domain (HJ30.4) and the tail region (HJ30.11). We utilized our assay to characterize neurofilament light in brain tissue and CSF …


Responding To Sexual Abuse In Health Care: Development Of A Guide For Patients, Tristan Mcintosh, Heidi Walsh, Meredith Parsons, Erin D Solomon, Jessica Mozersky, James M Dubois Jan 2022

Responding To Sexual Abuse In Health Care: Development Of A Guide For Patients, Tristan Mcintosh, Heidi Walsh, Meredith Parsons, Erin D Solomon, Jessica Mozersky, James M Dubois

2020-Current year OA Pubs

This report details the development of a stakeholder- and evidence-informed online resource guide for patients that provides information to raise awareness about sexual abuse in health care, the value of chaperones, and options for responding to sexual abuse. The guide was developed to reflect lessons learned from 10 years of researching physician wrongdoing (ie, sexual violations, improper prescribing, and unnecessary invasive procedures), a 5-year National Institutes of Health-funded mixed-methods study of 280 cases of egregious wrongdoing in medicine, and an expert working group. Focus groups were conducted with 22 patients from diverse backgrounds to obtain feedback on the acceptability of …


Creation Of Philadelphia Chromosome By Crispr/Cas9-Mediated Double Cleavages On Bcr And Abl1 Genes As A Model For Initial Event In Leukemogenesis, Minori Tamai, Kenji Kamimoto, Kohei Omachi, Et Al. Jan 2022

Creation Of Philadelphia Chromosome By Crispr/Cas9-Mediated Double Cleavages On Bcr And Abl1 Genes As A Model For Initial Event In Leukemogenesis, Minori Tamai, Kenji Kamimoto, Kohei Omachi, Et Al.

2020-Current year OA Pubs

The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chromosome 9q34 and the ABL1 gene located on chromosome 22q11. Thus, mimicking the initiation process of translocation, we induced CRISPR/Cas9-mediated DSBs simultaneously at the breakpoints of the BCR and ABL1 genes in a granulocyte-macrophage colony-stimulating factor (GM-CSF) dependent human leukemia cell line. After transfection of two single guide RNAs (sgRNAs) targeting intron 13 of the BCR gene and intron 1 of the ABL1 gene, a factor-independent subline was …


Estimation Of Intrafamilial Dna Contamination In Family Trio Genome Sequencing Using Deviation From Mendelian Inheritance, Christopher J Yoon, Brian Wiley, Malachi Griffith, Obi L Griffith, Et Al. Jan 2022

Estimation Of Intrafamilial Dna Contamination In Family Trio Genome Sequencing Using Deviation From Mendelian Inheritance, Christopher J Yoon, Brian Wiley, Malachi Griffith, Obi L Griffith, Et Al.

2020-Current year OA Pubs

With the increasing number of sequencing projects involving families, quality control tools optimized for family genome sequencing are needed. However, accurately quantifying contamination in a DNA mixture is particularly difficult when genetically related family members are the sources. We developed TrioMix, a maximum likelihood estimation (MLE) framework based on Mendel's law of inheritance, to quantify DNA mixture between family members in genome sequencing data of parent-offspring trios. TrioMix can accurately deconvolute any intrafamilial DNA contamination, including parent-offspring, sibling-sibling, parent-parent, and even multiple familial sources. In addition, TrioMix can be applied to detect genomic abnormalities that deviate from Mendelian inheritance patterns, …


Induction Egfr Tyrosine Kinase Inhibitors Prior To Definitive Chemoradiotherapy In Unresectable Stage Iii Egfr-Mutated Non-Small Cell Lung Cancer, Jacqueline V Aredo, Heather A Wakelee, Angela Bik-Yu Hui, Sukhmani K Padda, Nitin D Joshi, H Henry Guo, Aadel Chaudhuri, Maximilian Diehn, Billy W Loo Jr, Joel W Neal Jan 2022

Induction Egfr Tyrosine Kinase Inhibitors Prior To Definitive Chemoradiotherapy In Unresectable Stage Iii Egfr-Mutated Non-Small Cell Lung Cancer, Jacqueline V Aredo, Heather A Wakelee, Angela Bik-Yu Hui, Sukhmani K Padda, Nitin D Joshi, H Henry Guo, Aadel Chaudhuri, Maximilian Diehn, Billy W Loo Jr, Joel W Neal

2020-Current year OA Pubs

INTRODUCTION: Increasing evidence suggests that consolidation durvalumab confers limited benefits for patients with stage III EGFR-mutated NSCLC. Induction or maintenance EGFR tyrosine kinase inhibitors (TKIs) added to concurrent chemoradiotherapy (CRT) may optimize definitive treatment, but there are limited data supporting an induction TKI strategy.

METHODS: We evaluated the efficacy and safety of induction EGFR TKIs administered before concurrent CRT in a retrospective series of patients with unresectable locally advanced EGFR-mutated NSCLC. Circulating tumor DNA (ctDNA) analysis was performed on a patient subset using CAPP-seq and correlated with outcomes.

RESULTS: Of six patients, three received erlotinib and three osimertinib as induction …


Detection Of Emerging Neurodegeneration Using Bayesian Linear Mixed-Effect Modeling, Yann Cobigo, Richard J Perrin, Et Al. Jan 2022

Detection Of Emerging Neurodegeneration Using Bayesian Linear Mixed-Effect Modeling, Yann Cobigo, Richard J Perrin, Et Al.

2020-Current year OA Pubs

Early detection of neurodegeneration, and prediction of when neurodegenerative diseases will lead to symptoms, are critical for developing and initiating disease modifying treatments for these disorders. While each neurodegenerative disease has a typical pattern of early changes in the brain, these disorders are heterogeneous, and early manifestations can vary greatly across people. Methods for detecting emerging neurodegeneration in any part of the brain are therefore needed. Prior publications have described the use of Bayesian linear mixed-effects (BLME) modeling for characterizing the trajectory of change across the brain in healthy controls and patients with neurodegenerative disease. Here, we use an extension …


Primary Sources Related To The Greenwood Neighborhood, Tulsa Oklahoma, 1900-1921 (Bibliography), Patricia A. Schechter, Rebecca Hayes, Corry Hinckley Jan 2022

Primary Sources Related To The Greenwood Neighborhood, Tulsa Oklahoma, 1900-1921 (Bibliography), Patricia A. Schechter, Rebecca Hayes, Corry Hinckley

The Tulsa Race Massacre: Teaching and Learning Resources

Items in this bibliography were selected for their illustrative power and are intended to serve as an introduction to some of the source material available digitally to those interested in doing historical research related to the African American community of Tulsa, Oklahoma, roughly 1910-1921. The researchers strove for balance, including materials that describe the development of North Tulsa and “Black Wall Street” before the notorious race massacre of 1921. Transcripts of news reports of that event are also included in the final section of the bibliography.


Employment Status For “Essential Workers”: The Case For Gig Worker Parity, Miriam A. Cherry Jan 2022

Employment Status For “Essential Workers”: The Case For Gig Worker Parity, Miriam A. Cherry

All Faculty Scholarship

This Article explores what I call the “essential worker paradox”: During the pandemic, gig workers have been recognized as providing critical and important services. At the same time, the law has yet to recognize gig workers fully and to commit to providing them with the same basic protections as employees. The Article argues that the stark difference in treatment between gig workers and regular employees has long created unfairness. While views of gig work as a side hustle or work driven by customer convenience may have prevailed in the past, now the meal delivery driver and the on-demand grocery shopper …


Developing Standards For Gender-Responsive Human Rights Due Diligence, Constance Z. Wagner, Nancy Kaymar Stafford Jan 2022

Developing Standards For Gender-Responsive Human Rights Due Diligence, Constance Z. Wagner, Nancy Kaymar Stafford

All Faculty Scholarship

This article addresses the current state of gender-responsive human rights due diligence (GR-HRDD) standards and advocates for greater attention to be paid to women’s human rights in the due diligence process. The 2011 United Nations Guiding Principles on Business and Human Rights (UNGPs) created a global framework for recognizing, preventing, and addressing the risk of adverse impacts of human rights violations linked to business activities. The responsibility of businesses to respect human rights under the UNGPs includes implementing a human rights due diligence process. Although the UNGPs do not provide guidance on the process for integrating women’s rights into human …


Acknowledging The Racist Roots Of Disinvestment And Abandonment: How Local Government Can Set The Stage For Change, Dana M. Malkus Jan 2022

Acknowledging The Racist Roots Of Disinvestment And Abandonment: How Local Government Can Set The Stage For Change, Dana M. Malkus

All Faculty Scholarship

Disinvestment and associated property abandonment are defining features of many post-industrial legacy cities. While the reasons are varied and complex, racist law and policy are at the root. Though abandoned properties negatively affect an entire city, their effects usually disproportionately fall on neighborhoods of color. Law and policy have been major drivers of how such neighborhoods look and feel today. Because law and policy have been part of the problem, they are also a necessary part of the solution.

This kind of large-scale, multi-disciplinary problem is beyond the ability of a single institution or sector to address. Stakeholders such as …