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Reno-Protective And Immune Effects Of Growth Differentiation Factor 15 In Obesity-Related Kidney Disease, Jessie T. Sullivan

Honors Thesis

According to the World Health Organization, worldwide obesity has tripled since 1975 and is still on the rise, putting people at a higher risk of some cardiovascular diseases and kidney disease. Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine that has been studied recently for its role in multiple biological processes and diseases. The member of the transforming growth factor beta (TGF-b) family has been investigated as a therapeutic agent and biomarker for obesity and associated cardiovascular diseases, stroke, diabetes, osteoarthritis, cancer, and kidney disease. Studies have shown the anti-inflammation, anti-obesity, and anti-diabetic effects of GDF15, but few have …

Food Insecurity Among Niu College Students, Hannah Schaumberg

Student Projects

Many people with certain privileges never notice them, because they are so fixated on the hasty generalizations of what is seen on the surface rather than the interior aspects. For many students, understanding and recognizing privileges is the main concept to understanding their surroundings. The concept of reflecting on their interactions and knowledge of food insecurity will be curasol among communities. By researching the concepts of food insecurities among NIU students, we can bring awareness of the topic within society. The focus is to understand which intersectional groups are affected by food insecurity and to bring awareness of the subject …

Evaluation Of Awareness, Knowledge, And Preventive Intervention Of Nonalcoholic Fatty Liver Disease Among Chinese Young Adults, Yi Du

Theses & Dissertations

The prevalence of nonalcoholic fatty liver disease (NAFLD) among Chinese young adults (CYA) aged 18-25 years ranges from 4.7% to 15.1% and has kept increasing in recent years. Previous studies reported limited awareness and knowledge of NALFD among middle-aged and older Chinese populations, however, they have not investigated awareness in CYA, for which there is no well-validated questionnaire. There is currently no efficacious educational intervention on NAFLD for CYA.

The objectives were 1) to develop and validate a questionnaire which can be used to assess the awareness and knowledge of NAFLD among CYA; 2) to assess the awareness and knowledge …

Tourniquet-Induced Ischemia-Reperfusion Injury, Junliang Qian

Theses & Dissertations

Ischemia-reperfusion (IR) is a pathological condition characterized by an initial restriction of blood supply to an organ followed by subsequent restoration of reperfusion associated with exacerbation of tissue damage. For pre-hospital emergency situations and surgical procedures, tourniquet or femoral artery ligation are widely used to stop extremity hemorrhage or create a bloodless operating field. To fully evaluate the underlying mechanisms in IR pathophysiology and potential therapeutic options, we compared tourniquet- and femoral artery ligation-induced IR injuries in the hindlimb of mice. We found that tourniquet/IR-induced acute hindlimb injuries are more severe than those induced by femoral artery ligation/IR, including alteration …

Polymeric Nanocarriers For Delivery Of Small Molecules Inhibiting Tubulin Polymerization For The Treatment Of Pancreatic Cancer And Lung Metastatic Melanoma, Rajan Sharma Bhattarai

Theses & Dissertations

The aim of this thesis is to develop delivery systems for the novel small molecules which inhibit tubulin polymerization. One of the small molecules was modified to lipid conjugate to increase the lipophilicity of the molecules which in turn drastically improved the drug loading in amphiphilic polymeric system. The second molecule was conjugated to the amphiphilic polymeric backbone with pH sensitive Schiff’s linker for the tumor site specific delivery in lung metastatic melanoma model.

Chapter 1 discusses the tumor microenvironment for the solid tumor especially focusing on Pancreatic Ductal Adenocarcinoma (PDAC). Further the drug delivery system currently researched for addressing …

Body Image Perceptions Reflected In Social Media: A Guatemalan Instagram Study, Sarah Harris

Honors Theses

Guatemala has faced a long battle with colonialism, civil war, and an ensuing, rapid urbanization. Still today, the country exhibits high levels of malnourishment while also facing an ascending obesity epidemic. This project seeks to explore how the obesity epidemic has changed body image perceptions in the region. Through the use of social media accounts on Instagram, I aim to analyze how Guatemalan influencers use their platform to explore notions of varying body image perceptions in a country where food is culturally significant, malnutrition has plagued many communities, and obesity is growing in prevalence daily. This thesis aims to answer …

An Exploration Of Physical Education Teachers’ Perceptions Of And Experiences With Body Image, Natallie Noel

Honors Theses

Adolescents experience a broad range of physical and emotional changes and begin looking to peers and social media to determine what their bodies should look like through the lens of society. This process of adolescents beginning to visualize themselves is known as body image. These include physical competence, motivation, self-esteem, and confidence through the way the teachers interact with students, develop positive learning spaces, and develop and implement intentional instruction and programs, thus, providing a space where adolescents begin to develop a healthy perception of their own body (Kerner et al., 2017). However, the breadth of literature on body image, …

Assessment Of Spatial Skills In Human Anatomy And Physiology Students, Abigail Carroll

Honors Theses

Visual spatial skills are an individual’s ability to mentally and manipulate the shapes, forms and positions of objects. Spatial skills are necessary for adequate learning in many settings. Few studies have assessed spatial skills compared to success in Anatomy and Physiology in undergraduate students. Most students in this course are on a health profession track. Due to the increasing health care demands and need for competent health care professionals, this study assesses the innate spatial skill ability in students and acquired additional learned spatial skills. This study tests 17 students with the paper-folding test, blank page test, and two surveys …

Increasing Accessibility To Monitoring Ammonia Levels In The Body Through Development Of A Novel Point-Of-Care Breath Ammonia Diagnostic Device, Emily C. Wright, Ashwin M. Sivalingam

Honors Theses

Hyperammonemia is a life-threatening metabolic condition that is characterized by elevated levels of ammonia concentrations in the blood. Resulting from serious conditions such as chronic kidney disease or liver failure, the limited functions of the liver and kidney lead to an increase in blood urea nitrogen (BUN) within the body. Currently, there are a wide variety of treatments for this condition, ranging from various medications to surgical procedures such as liver transplants. However, there is a lack of variety in diagnostic testing methods to determine a patient’s ammonia levels. In most cases, patients will need to schedule a doctor’s appointment …

Restoration Through Reassembly: Evaluating The Role Of Native Plants In Combatting Chinese Tallow, Olaniyi Ajala

Electronic Theses and Dissertations

Non-native, invasive species disrupt ecological processes and functions, posing a serious threat to natural ecosystems. By examining the growth metrics of the non-native, invasive tree, Chinese tallow (Triadica sebifera [L.] Roxb.), hereafter tallow, across different flooding and light regimes, I investigated how restructuring native communities with valuable native species will prevent the reestablishment of tallow. I studied the changes in morphological and physiological traits of tallow when growing with water tupelo (Nyssa aquatica L.), sugarberry (Celtis occidentalis L.), and green ash (Fraxinus pennsylvanica Marshall). I found that in the non-flooded and high irradiance treatments, tallow's growth …

An Occupation-Based Approach To Empower Individuals Experiencing Homelessness, Sydney L. Bodensteiner

Occupational Therapy Capstone Presentations

Individuals experiencing homelessness often have decreased occupational participation in all domains of occupational therapy practice. The purpose of this capstone experience was to explore the role of occupational therapy among individuals experiencing homelessness. in Rapid City, SD. A Needs Assessment was developed in collaboration with Fork Real Community Café and the HOPE Center in order to identify the occupational needs of individuals experiencing homelessness in the Rapid City community. With the needs identified, I led holistic, client-centered, individual and group interventions to increase the occupational participation of guests. For individual interventions, guests completed the Canadian Occupational Performance Measure to determine …

The Sustainability Rhetoric Among The Spanish Fashion Companies Involved In The Rana Plaza Collapse Of 2013, Keegan Lyle

Honors Theses

Over the last century, fashion has evolved to become a commodity that is rapidly changing and easily available. The processes that have led to this accessibility of fashion, however, have proven to be harmful to the environment and, most recently, proven to be potentially fatal for the people making the clothing. In 2013, a garment factory in Bangladesh, housing production for major global fashion brands, like Zara and The Children’s Place, collapsed following a series of negligence. The event has sparked years of awareness-raising in the public dialogue of fast fashion. As a part of the newly-developing research in sustainable …

Measles And Migration In Colombia And Brazil: Determinants Of Differential Disease Impact Resulting From The Venezuelan Crisis, Kaylen Hisle

Honors Theses

This thesis investigates the 2018 measles outbreaks that occurred in Colombia and Brazil as a result of importation from Venezuela, seeking to uncover underlying factors contributing to significantly greater case numbers in Brazil than in Colombia. It analyzes vaccination coverage, migrant integration, and migration policy, using a mixed-methods approach to compare the two countries. Qualitative analysis of the border zones, migration policies, health systems, and progression of the outbreaks in each country reveals that geographical and socioeconomic differences at the borders, heterogeneity of vaccination coverage, timeliness of policy responses, and disease tracing capabilities could all be possible contributors to greater …

The Impact Of Sleep On Athletic Performance: A Review Of The Literature, Rylan J. Pratt

Honors Thesis

This paper reviewed the literature regarding sleep and athletic performance, specifically identifying the problem of sleep debt in student athletes, the effects of sleep debt, and what factors negatively influence sleep, along with how to improve sleep. The literature revealed that it is common for athletes to not get adequate sleep. Sleep debt can have psychomotor and physiological effects on the body, which decreases optimal athletic performance. The many factors that negatively impact sleep include high intensity training sessions, travel, sleep disturbances, caffeine and/or alcohol consumption, and pre-competition anxiety. Recommendations for athletes that are struggling to achieve adequate sleep include, …

Paleopathological Analyses Of Maya Skeletal Samples To Reconstruct Childhood Health And Frailty, Kira J. Wilde

Honors Thesis

Nonadults are particularly sensitive and reactive to stress, illness, and injury and, as such, they are good proxies for examining health of past populations based on evidence of stress events recorded in their skeletal and dental remains. Skeletal data on childhood stress and frailty was derived from nineteen individuals sourced from the BVAR skeletal collection, which was excavated from Maya settlements in the Belize River Valley and dated from the Early and Late Classic (250-900 CE) periods of the ancient Maya kingdoms. Osteological analyses included age-at-death estimation for adults and nonadults, following the criteria of Buikstra and Ubelaker (1994) and …

Development And Evaluation Of Enhanced Recovery After Surgery Protocols For General Abdominal And Orthopedic Surgery With Focus On Preoperative Hydration And Multimodal Management In Preoperative And Postoperative Phases, Kristin Wolff, Sadie Spilker

Doctor of Nursing Practice Projects

Enhanced Recovery After Surgery (ERAS) is described as an evidence-based, patient-centered, interdisciplinary team developed protocol utilized to decrease the patient’s stress response to surgery, maintain preoperative physiologic function, and expedite recovery (American Association of Nurse Anesthetists [AANA], 2017). Existing evidence displayed the benefits of utilizing ERAS protocols in various surgical procedures, including general and orthopedic cases. Studies showed one must employ the preoperative, intraoperative, and postoperative components of the ERAS protocols to achieve maximum benefits. A critical access hospital in Illinois utilized some components of ERAS protocols, mainly the intraoperative portions, but lacked the full utilization. Goals of the review …

Feasibility And Efficacy Of Bisphosphonate Use For The Prevention Of Bone And Muscle Loss, Laura E. Flores

Theses & Dissertations

Loss of bone and muscle mass often occurs in tandem, increasing the risk of fragility fractures. Whereas many drugs are approved for the treatment of bone loss, there are few treatments available for the concomitant loss of bone and muscle. Identification of a treatment to mitigate pathologic bone and muscle atrophy has the potential to impact countless populations and influence approaches for healthy aging. Bisphosphonates have emerged as a potential treatment for both bone and muscle loss in cellular, murine, and observational human studies. Our findings of modest weight maintenance in postmenopausal women treated with 12-months of risedronate, relative to …

Modulating Cellular Senescence To Improve Age-Associated Wound Healing Impairment, Upasana Niyogi

Theses & Dissertations

Impaired tissue repair and regenerative ability in the aged is a major socio-economic and clinical problem. One of the likely factors associated with poor wound healing is the presence of lingering senescent cells in the wound sites. Failure to eliminate these cells has been associated with inadequate healing, excessive scarring, and abnormal skin stiffening. Thus, the objective of our study was to test interventional strategies to mitigate the negative effect of senescent cells. We hypothesized that reducing senescent cell burden and promoting non-senescent cell functionality will improve wound healing with age.

We developed a 3D in vitro senescent fibroblast populated …

Visceral Adipose Tissue Remodeling In Pancreatic Ductal Adenocarcinoma Cachexia: The Role Of Activin A Signaling, Pauline Xu

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer death in the United States and is projected to become the second leading cause by the year 2030. Prognosis for patients with metastatic disease remains dismal, with cachexia as a main contributor to the low survival rate. Emerging reports indicate that PDAC patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. While muscle wasting has been the most frequently studied mechanism in cachexia research, changes in adipose tissue are increasingly understood as important components of …

Biologically-Inspired Nanoparticles For Oncology Applications, Aishwarya Bapat

Theses & Dissertations

Cancer is the leading cause of death in the United States and its high mortality rate can be attributed towards poor diagnosis methods and less effective therapeutic treatments. Many nanotechnology-based diagnostics and therapeutics are being developed to improve cancer patient outcomes. In this work, we have studied nanoparticles for diagnostic and therapeutic applications in cancer treatment.

In the first work, novel fluorescent NPs loaded with indocyanine green (ICG) were developed for bioimaging applications of pancreatic cancer. Targeted fluorescent nanoparticles (NPs) are being developed to image a range of cancer types with the goal to improve patient outcomes by utilizing in …

Investigation Of Cumulative Genetic Risk And Cc16 In Adult Asthma And Copd Populations, Kelli C. Gribben

Theses & Dissertations

INVESTIGATION OF CUMULATIVE GENETIC RISK AND CC16 IN ADULT ASTHMA AND COPD POPULATIONS

Kelli C. Gribben, Ph.D.

University of Nebraska Medical Center, 2022

Supervisors: Paraskevi A. Farazi and Tricia D. LeVan, Ph.D.

Asthma and Chronic Obstructive Pulmonary Disease (COPD) have complex etiologies and lack biological predictors that can be used for primary prevention, early detection, progression, or monitoring. Genetic risk scores (GRS) aggregate genetic effects from GWAS-identified susceptibility variants associated with a trait. GRS may provide opportunities to improve disease prediction to inform public health and clinical interventions. Asthma GRS studies utilizing multi-ethnic populations are scarce and there is a …

Regulation Of Pancreatic Cancer Progression By Micronutrients, Chunbo He

Theses & Dissertations

Cancer cells rely on altered metabolism to support their uncontrolled proliferation under harsh conditions. Understanding the mechanisms of how metabolic alterations support tumor growth may provide a way to enhance current therapies. Vitamins are micronutrients that our body needs in small quantities but are essential for health maintenance. A number of metabolic processes relevant to cancer initiation and progression are also regulated by vitamins. Here, our studies showed that pancreatic ductal adenocarcinoma (PDAC) cells display an aberrant metabolism of vitamin B6 (VB6) to support their fast proliferation. VB6 was highly demanded and rapidly metabolized by PDAC cells. Depletion of VB6 …

The Development Of Thermoresponsive Hydrogel-Based Drug Delivery Systems For The Treatment Of Musculoskeletal Diseases, Ningrong Chen

Theses & Dissertations

Water-soluble polymers are one of the most commonly used drug delivery vehicles for musculoskeletal diseases. During the past few decades, various biocompatible polymers have been employed in the development of thermoresponsive hydrogels as drug delivery systems for the treatment of local musculoskeletal pathologies. As part of our laboratory’s contribution to this field of study, I have successfully developed three thermoresponsive hydrogel-based formulations for the treatment of three different pathologies associated with the musculoskeletal system.

As my initial effort, I have developed a bone-targeting injectable hydrogel drug delivery system based on Pluronic 127 (Poloxamer 407), which is a Generally Recognized As …

Researching Of The Shelf Life And Quality Of Margarine Enriched In Inulin, Shakhnozakhon Salijonova, Akbarali Ruzibayev

CHEMISTRY AND CHEMICAL ENGINEERING

Extensive research is being carried out in the world on the effective use of non-traditional plant raw materials, its production in margarine, mayonnaise and similar oil and fat products. In this aspect, special attention is paid to improving targeted technological processes, developing margarine formulations from local raw materials, increasing the nutritional and biological value of products, efficient use of natural raw materials and expanding the range of products. The aim of the study is to study the shelf life of the obtained diabetic low-calorie margarine based on the extract of Jerusalem artichoke tubers. Based on the research, it was determined …

Research Of The Process Of Obtaining Crystalline Monocalcium Phosphate Based On Extraction Phosphoric Acid From Phosphorites Of Central Kyzylkums, Kholtura Mirzakulov, Gavkhar Melikulova, Mohichehra Shaymardanova, Sherzod Khujamberdiev

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the research is to establish the optimal parameters of the technological process for the production of feed, crystalline monocalcium phosphate based on defluorinated and desulphated extraction phosphoric acid obtained from phosphorites of the Central Kyzylkum and limestone.

The influence of technological parameters, such as the norms and concentration of phosphoric acid, the process temperature on the filtration rate indicators, the rheological properties of the suspension and the mother liquor, as well as the dependence of the change in the commercial property of crystalline feed monocalcium phosphate, were studied.

It is shown that, regardless of the initial acid …

The Understanding Of Mycorrhizae Networks: A Historical Approach, Jake Sun

The Confluence

The growth of mycorrhizal fungi into plant roots used to be viewed as a parasitic relationship between plants and fungi, where the fungal symbiont benefits and the plant host is harmed. Current research elucidates a mutualistic relationship. The mycorrhizae network assists the plants by increasing the capabilities for nutrient absorption in the soil. In exchange, the fungi receive carbon supply from the photosynthetic plants for growth. Our scientific understanding of other topics like species specificity, seed germination, and co-evolutionary influence of mycorrhizae and plants has also progressed. Additionally, we now understand that the mycorrhizal mutualism is not limited to the …

On The Restorative Power Of Nature, Or Why Every Neighborhood Needs A Public Japanese Garden, Mira Locher, Keith Bartholomew

Journal of Comparative Urban Law and Policy

In celebration of Professor Arthur C. “Chris” Nelson’s illustrious career and our shared ambles in academia and in gardens in Japan, we offer this essay on public health and public gardens, namely gardens in the traditional Japanese style and how they could play an important role in addressing pressing public health issues in urban areas in the U.S. (and elsewhere).

Land-Use Planning And Urban Governance: Lessons From The Pandemic, Malcolm Grant

Journal of Comparative Urban Law and Policy

It is a privilege to have been invited to contribute to this festschrift for a scholar whose work I have known and admired for decades. We have explored and debated together many aspects of land-use planning in our respective jurisdictions over that time, including a protracted effort in the 1990s to develop a model for impact fees for the UK planning system. Several other contributors to this festschrift were also part of that team, from which all of us learned a great deal. One is that complex systems of government develop deep resistance to change, and that it often takes …

Importance Of Developing Financially Literate Families And Communities: Opportunities For Fcs Educators, Stephen Molchan

Journal of Educational Research and Practice

Financial literacy has been an issue for decades in the United States; however, the COVID-19 pandemic put financial illiteracy in the spotlight. Family and Consumer Sciences (FCS) educators have the ability to influence the financial literacy rates among individuals, families, and communities. Despite Hogarth’s 2002 call to action for FCS educators to promote fiscal education, this has not happened. FCS educators must now respond to this call. This manuscript addresses the financial illiteracy problem in the United States, the importance of financial literacy, financial literacy in the FCS National Standards, and the actions FCS educators can take to improve financial …

Spring Dance Concert, Jennifer Backhaus, Liz Curtis

Dance Programs

No abstract provided.