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The Presynaptic Role Of Phosphagen Systems, Carlos David Oliva

Harriet L Wilkes Honors College Theses 2020 - Present

De novo generation of ATP through glycolysis and oxidative phosphorylation is too slow to sustain intense neuronal activity and stabilize ATP levels, suggesting there might be another energy pool at play. The phosphagen system, extensively researched in muscles, is an ATP regeneration pathway; quickly producing ATP through ADP re-phosphorylation. Its presence has been observed in neurons, yet its involvement in neuronal power demands remains poorly understood. To investigate the phosphagen system’s impact on neuronal energy metabolism, we examined Drosophila melanogaster motor neurons, which had arginine kinase knocked down while using genetically-encoded fluorescent reporters of pH, calcium, and ATP. Data obtained …

Pre-Existing Diabetes Mellitus, Hypertension And Kidneydisease As Risk Factors Of Pre-Eclampsia: A Disease Of Theories And Its Association With Genetic Polymorphism, Abdullah Salah Alanazi, Francis Victor, Kanwal Rehman, Yusra Habib Khan, Ismaeel Yunusa Ph.D., Abdulaziz Alzarea, Muhammad Sajid Hamid Akash, Tauqeer Hussain Mallhi

Faculty Publications

Pre-existing diabetes, hypertension and kidney disorders are prominent risk factors of pre-eclampsia (PE). It is a multifactorial pregnancy disorder associated with high blood pressure, proteinuria, and multiorgan failure, which develops after the 20th week of pregnancy. It is one of the most feared pregnancy disorders, as it consumes thousands of fetomaternal lives per annum. According to clinical and pathological studies, the placenta appears to be a key player in the pathogenesis of PE; however, the exact origin of this disorder is still under debate. Defective placentation and angiogenesis are the hallmarks of PE progression. This angiogenic imbalance, together with maternal …

Efficacy And Safety Of Fecal Microbiota Transplantation In Treatment Of Clostridioides Difficile Infection Among Pediatric Patients: A Systematic Review And Meta-Analysis, Kyaw Min Tun, Mark Hsu, Kavita Batra, Chun-Han Lo, Tooba Laeeq, Tahne Vongsavath, Salman Mohammed, Annie S. Hong Md

Department of Internal Medicine Faculty Research

Background and Aims: Cases of Clostridioides difficile infection have been rising among the pediatric and adolescent population. Fecal microbiota transplantation (FMT) has emerged as an alternative therapy for recurrent C. difficile infection. We aim to perform the first systematic review and meta-analysis investigating the safety and efficacy of fecal microbiota transplantation for C. difficile infection in children and adolescents. Methods: A literature search was performed using variations of the keywords “pediatrics”, “C. difficile infection”, and “fecal microbiota transplantation” in PubMed, EMBASE, CINAHL, Cochrane, and Google Scholar from inception to 30 June 2022. The resulting 575 articles were independently screened by …

Preventative Healthcare Programs, Caileb T. Reilly

Honors Thesis

The healthcare system in the United States is struggling with excessive costs and disproportionate quality measures. While the U.S. spends the most on healthcare in the world, the quality of the healthcare is not reflected in this cost. With excessive spending being the strategy to improve quality in the past, new strategies need to be implemented to improve quality as increased spending is not raising this statistic. One factor that can improve quality and reduce costs is the introduction and utilization of preventative healthcare programs. These programs are built to keep at-risk populations from developing serious, permanent diseases that deplete …

Identity Work To Teach Mathematics For Social Justice, Navy B. Dixon

Theses and Dissertations

In this thesis, mathematics educators are conceptualized as individuals with multiple, simultaneous figured worlds that inform their decisions while planning. The study explores how two mathematics educators negotiated and orchestrated their figured worlds to plan two mathematics lessons for social justice. The results highlight how numerous the figured worlds each participant surfaced through background interviews. Some of the figured worlds were elicited by the interview questions (i.e., Race, Family, Social Justice Teaching) but other figured worlds organically surfaced through the interviews (i.e., Sexuality, Community, Activism, Critical Information Consumption). A discursive analysis of a selection of these figured worlds revealed conceptualizations …

Icc Agenda 12-6-22, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

F-Box Receptor Mediated Control Of Substrate Stability And Subcellular Location Organizes Cellular Development Of Aspergillus Nidulans, Bayram Ö Sarikaya, Ö Bayram, B Karahoda, C Meister, Am Köhler, S Thieme, N Elramli, D Frawley, J Mcgowan, Da Fitzpatrick, K Schmitt, Leandro Jose De Assis, O Valerius, Gh Goldman, Gh Braus

Peninsula Medical School

Fungal growth and development are coordinated with specific secondary metabolism. This coordination requires 8 of 74 F-box proteins of the filamentous fungus Aspergillus nidulans. F-box proteins recognize primed substrates for ubiquitination by Skp1-Cul1-Fbx (SCF) E3 ubiquitin RING ligases and degradation by the 26S proteasome. 24 F-box proteins are found in the nuclear fraction as part of SCFs during vegetative growth. 43 F-box proteins interact with SCF proteins during growth, development or stress. 45 F-box proteins are associated with more than 700 proteins that have mainly regulatory roles. This corroborates that accurate surveillance of protein stability is prerequisite for organizing multicellular …

2022 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.

Distribution And Soil Characteristics Associated With The Neches River Rose-Mallow (Hibiscus Dasycalyx), Morgan E. Langlinais

Electronic Theses and Dissertations

The Neches River rose-mallow, Hibiscus dasycalyx, is a rare herbaceous perennial endemic to East Texas. The threatened, obligate wetland species is currently at risk of being lost in the wild due to habitat loss, encroachment of nonnative and native plant species, and hybridization with two other Hibiscus congeners, Hibiscus laevis and Hibiscus moscheutos. Known locations of each of the three Hibiscus species were used to measure select soil characteristics and habitat variables associated with each of the rose-mallows. H. dasycalyx was concluded to be associated with more fertile soils and slightly more canopy coverage than H. laevis and …

Next-Generation Sequencing Shows Increasing Temperatures Affect Stream Fungal Communities, Regan Hodgson

Electronic Theses and Dissertations

Under climate change predictions, surface air temperature is expected to continue to rise and will likely affect functioning of stream ecosystems and microbial communities. Aquatic hyphomycetes are key fungal decomposers of plant litter in headwater streams controlling carbon, energy, and nutrient flows to higher trophic levels. This project addressed the effects of temperature on stream fungal communities in two recently conducted experiments (microcosm and streamside channel studies) using Illumina sequencing. The objectives were to determine (1) if temperature affects community structure of stream fungi based on relative abundances of ITS2 rDNA sequences, (2) if the effects of temperature on aquatic …

Abundance And Growth Of Juvenile Atlantic Sturgeon In The Edisto River, Sc, Molly Katherine Takacs

Electronic Theses and Dissertations

Information on abundance and body growth are important for understanding the status and health of populations, and this information can be used to guide and monitor conservation and recovery efforts for species of conservation concern. The Atlantic Sturgeon (Acipenser oxyrinchus oxyrinchus) is an anadromous fish native to the Atlantic coast of the United States and Canada. Due to overfishing and habitat degradation, population levels declined, and Atlantic Sturgeon were placed on the Endangered Species list in 2012. Although there is substantial research on adult Atlantic Sturgeon, knowledge about their early life history is lacking. The objective of this study were …

Habitat Use And Diel Movements Of Silver Carp Hypophthalmichthys Molitrix In Two Southeastern Reservoirs, Levi Umland

Honors College Theses

Bigheaded carp have spread rampantly throughout the Mississippi watershed and continue to spread by navigating through rivers, locks, and dams. The long-term effects these species will have on our ecosystems and natural resources is unknown. Their movements, behavior, and general seasonal patterns are well studied within rivers. However, their movements and behavior within reservoirs is poorly understood due to their initial numbers within reservoirs being lower than in rivers. To address this gap, I investigated the distribution and movement rates of Silver Carp within two reservoirs, Kentucky Reservoir and Barkley Reservoir, and possible correlative variables, including wind, temperature, residency, sex, …

Respons Komponen Hasil Dan Hasil Varietas Padi Berprotein Tinggi Terhadap Pemberian Dosis Pupuk Nitrogen, Agus Riyanto, Dyah Susanti, Totok Agung Dwi Haryanto

Jurnal Kultivasi

Inpago Unsoed Protani dan Inpari Unsoed P20Tangguh adalah padi (Oryza sativa L.) daya hasil tinggi yang memiliki kandungan protein beras tinggi yang pertumbuhannya dipengaruhi oleh pemupukan nitrogen. Tujuan penelitian ini adalah mengetahui respons komponen hasil dan hasil padi protein tinggi terhadap pupuk nitrogen dan memperoleh dosis optimal pupuk nitrogen untuk varietas Inpago Unsoed Protani dan Inpari Unsoed P20Tangguh. Percobaan dirancang dengan RAK pola faktorial dwi faktor yang diulang tiga kali. Faktor pertama adalah dosis pupuk N yaitu: 0 kg N ha-1, 46 kg N ha-1, 92 kg N ha-1, dan 138 kg N ha-1. Faktor kedua adalah genotipe padi yaitu …

Potential Use Of Pgpr Based Biofertilizer For Improving The Nutrient Availability In Soil And Agronomic Efficiency Of Upland Rice, Rahma Tia Harahap, Diyan Herdiyantoro, Mieke Rochimi Setiawati, Isna Niar Rahmatul Azizah, Tualar Simarmata

Jurnal Kultivasi

Present study aimed to perform literature review to investigate the current status and potential use of plant growth promoting rhizobacteria (PGPR) for enhancing the soil plant’s health, plant growth and productivity in sustainable ways. The Systematic Literature Review (SLR) methods was applied according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) on published scientific literature from 2012-2022. Results revealed that genus diversity of PGPR (Bacillus sp., Serratia sp., Streptomyces sp., Pseudomonas sp., and Burkholderia sp.) produce siderophore and phytohormones such as indole-3-acetic acid (IAA), gibberellin (GAs), auxin, and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase activity, organic acids, biocontrol agent that …

Low-Income New Hampshire Parents’ Food Acquisition Decisions, Sarah Boege, Jess Carson

Carsey Publications

Drawing on interviews with 16 low-income New Hampshire parents in 2022, this paper explores the complex decisions that families make in choosing what foods to buy and where (and how) to shop.

The Growth Of 'Crystal' Guava Seedling In Response To Pinching And Dormancy Breaking Chemicals, Raden Ajeng Diana Widyastuti, Setyo Dwi Utomo, Darwin H. Pangaribuan, Purba Sanjaya, Hayane Adeline Warganegara, Widia Agustin

Jurnal Kultivasi

Pinching and dormancy breaking chemicals (DBC) application are potentially used to regulate the growth of plant. This study aims to evaluate the growth response of ‘Crystal’ guava (Psidium guajava L.) seedling in response to pinching and DBC application. This experiment was carried out in the Integrated Field Laboratory, Faculty of Agriculture, Universitas Lampung from March to June 2021, with a randomized completely block design (RCBD) with 2 factors (pinching and DBC) and repeated four times. The results showed that pinching could reduce the increase of height of guava seedling. The combination of pinching with DBC could significantly increase the number …

Teknik Fermentasi Campuran Bahan Organik Sebagai Sumber Nutrisi Organik Pada Sayuran Sawi Yang Ditanam Dengan Hidroponik, Darwin H. Pangaribuan, Yohannes Cahya Ginting, Rugayah, Purba Sanjaya, Agus Karyanto, Kurnia Cahyani Dewi, Intan Puspita Sari

Jurnal Kultivasi

Nutrisi organik untuk budidaya sistem sumbu hidroponik merupakan salah satu alternatif untuk mengatasi kendala mahalnya harga pupuk anorganik. Penelitian ini bertujuan untuk mengetahui metode ekstraksi terbaik antara metode air hangat, air dingin, dan fermentasi kemudian menentukan waktu fermentasi terbaik dari unsur hara organik campuran rumput laut, sabut kelapa dan daun kelor yang diharapkan memiliki kandungan nutrisi organik yang mendekati dengan formula nutrisi anorganik. Penelitian ini terdiri atas 2 percobaan: (i) percobaan pertama meneliti jenis metode ekstraksi, dan (ii) percobaan kedua meneliti waktu fermentasi terbaik. Rancangan percobaan yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan faktor tunggal dan diulang sebanyak 6 …

How Can You Call Her A Woman? Male Soldiers’ Views On Women In The Drc Armed Forces, Dostin Lakika, Ingrid Palmary

Peace and Conflict Studies

There has been a longstanding body of literature on women in the armed forces at least since the 1970s (Segal, 1999). This literature varies considerably in its approach, from feminist work that reflects on the forms of masculinity produced through military and militarization, to work that considers women’s role in the army and attitudes towards women in the army. Furthermore, policy efforts to increase women’s participation in the army (such as UN Security Council Resolution 1325) have explicitly called for the inclusion of women in peace and security efforts. In this paper, we contribute to this literature by assessing how …

The Ongoing Search For Democracy: A Comparative Analysis Of Racial Equality In Cuba And The United States, Michael T. Siderio Jr.

Honors Student Research

This Capstone Project is structured as a comparative analysis of the fight for racial equality for Afro-Cubans in Cuba and how it compares to racial equality for African Americans in the United States, specifically focusing on contemporary issues relating to employment and economic opportunities, as well as police brutality. Historical background will be given on each topic within the scope of racial equality, and a comparative analysis on how they are similar and how they differ will also be provided. The overarching goal of the research on historical background and doing the comparative analysis is to synthesize both respective movements …

Sizeism--What Multicultural Education & Training Are Missing, Jen Rynes

Counselor Education Capstones

Training in multiculturalism is a major focus in most counselor education graduate programs. These programs seek to graduate competent counselors who aspire to serve all populations. The harsh reality is that many programs fail to acknowledge body diversity and sizeism in these multicultural courses and trainings. There are a multitude of reasons why body diversity needs to be a part of multicultural education and training. The literature reviewed in this paper has a purpose of discussing those reasons, dismantling the many myths associated with fatness, identifying how body size intersects with other diverse identities, and reviewing current multicultural guidelines and …

Paid Advertising: Understanding How Ad Format And Visuals Impact Ad Link Clicks And Conversions, Samantha Ensinger

Honors Projects

Limited research exists that effectively describes what format of ads (photos, videos, graphics, or GIFs), receive the most link clicks, the most adds-to-cart, and the most conversions. There is even less research available that describes the extent to which the visual structure of advertisements, such as chosen colors, imagery, text, and duration impacts ad performance. This study sets out to address and help close this research gap by creating and testing multiple advertisements on Facebook and Instagram.

December 9, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Wearable Sensors For Plants, Nafize Ishtiaque Hossain

Electrical Engineering Theses

This thesis reports PlantFit: a research and development project that is intended to develop wearable sensors for plants. Plants are responsible for providing food, fiber, fuel, and fodder to the society. To overcome the problem of a limited land base, a more efficient farming approach needs to be developed, and thus precision farming is required. Precision farming would entail personalized healthcare in plants. When the plant is under any stress, the productivity declines. Plants release phytohormones, also known as early responders, in response to these stressors. The key crop phytohormones that respond to environmental stresses include salicylic acid (SA), indole-3-acetic …

Unpacking Athletics: An Exploration Of Identity Development For Division I Women College Athletes, Kathleen E. Scanlon

Dissertations - ALL

This dissertation explored how former Division I National Collegiate Athletic Association (NCAA) women athletes made meaning of their undergraduate experience and how it influenced their post-graduate lives. The study research questions focused on three areas: a) how participants constructed meaning from their athletic experiences and what role those experiences had in shaping their identity; b) how the participants made sense of the various systems they experienced and what bearing various identities had on their meaning making; and c) what concrete knowledge, skills and qualities participants felt they possessed today that they attribute to their intercollegiate athletic experiences.

Three semi-structured interviews …

Effects Of A Behavioral Intervention On Physical Activity, Diet, And Health-Related Quality Of Life In Pregnant Women With Elevated Weight: Results Of The Hipp Randomized Controlled Trial, Sarah Wilcox Phd, Jihong Liu, Gabrielle Turner-Mcgrievy Ph.D., Rd, Alycia K. Boutte, Ellen Wingard Msph, Rd, Ld

Faculty Publications

Background

Physical activity (PA), diet, and health-related quality of life (HRQOL) are related to maternal and infant health, but interventions to improve these outcomes are needed in diverse pregnant women with elevated weight.

Methods

Health In Pregnancy and Postpartum (HIPP) was a randomized controlled trial. Women who were pregnant (N=219, 44% African American, 56% white) with overweight or obesity but otherwise healthy were randomized to a behavioral intervention grounded in Social Cognitive Theory (n=112) or to standard care (n=107). The intervention group received an in-depth counseling session, a private Facebook group, and 10 content-based …

Effects Of A Behavioral Intervention On Physical Activity, Diet, And Health-Related Quality Of Life In Pregnant Women With Elevated Weight: Results Of The Hipp Randomized Controlled Trial, Sara Wilcox Ph.D., Jihong Liu, Gabrielle Turner-Mcgrievy Ph.D., Rd, Alycia K. Boutté, Ellen Wingard

Faculty Publications

Background

Physical activity (PA), diet, and health-related quality of life (HRQOL) are related to maternal and infant health, but interventions to improve these outcomes are needed in diverse pregnant women with elevated weight.

Methods

Health In Pregnancy and Postpartum (HIPP) was a randomized controlled trial. Women who were pregnant (N=219, 44% African American, 56% white) with overweight or obesity but otherwise healthy were randomized to a behavioral intervention grounded in Social Cognitive Theory (n=112) or to standard care (n=107). The intervention group received an in-depth counseling session, a private Facebook group, and 10 content-based …

Inhibition Of The Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib In Loss-Of-Function Notch1-Mutant Head And Neck Cancer, Faye M Johnson, Filip Janku, Mohamed A Gouda, Hai T Tran, Jitesh D Kawedia, Debora Schmitz, Hendrik Streefkerk, J Jack Lee, Clark R Andersen, Defeng Deng, Seema Rawal, Pooja A Shah, Adel K El-Naggar, Jason M Johnson, Mitchell J Frederick

Faculty, Staff and Student Publications

BACKGROUND: PI3K/mTOR inhibition leads to apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma (HNSCC) cells. We tested the efficacy of the PI3K/mTOR inhibitor bimiralisib in patients with NOTCH1-mutant HNSCC.

METHODS: Patients with recurrent/metastatic NOTCH1-mutant HNSCC who had progressed during chemotherapy and immunotherapy received bimiralisib until unacceptable toxicity or progression. To assess whether NOTCH1 mutations can be detected in blood, we measured circulating tumor DNA (ctDNA). To assess activated NOTCH1 protein levels, we quantitated cleaved NOTCH1 (cl-NOTCH) by immunohistochemistry.

RESULTS: Eight patients were treated, and 6 were evaluable for response. The objective response rate was 17%. For all 8 patients, …

Food Insecurity Among College Students: Perception Of College Administrators, Ibiyemi Adesanya

Seton Hall University Dissertations and Theses (ETDs)

Abstract

While food insecurity among college students has existed for decades, only in recent years has the focus on the impact of food insecurity on student success emerged. However, most of the research has been quantitative, conducted at public two-year and four-year colleges and focused on predictors, prevalence, and impact of food insecurity among college students. Although prior student-based research has been beneficial to understand the problem, there is inconsistency in how institutions and higher education professionals address this issue with their students.

A transcendental phenomenological single case study design was used in this study to explore the lived experience …

Ways To Decrease Risk Of Postpartum Hemorrhage, Madison Holcomb

Honors Theses

Postpartum hemorrhage (PPH) is the leading preventable cause of maternal mortality (Jena et al., 2022). In fact, it accounts for 25% of maternal deaths globally (Cooper et al., 2022). There is a tremendous need for education to the pregnant population There are methods to decrease the risk that needs to be taught to patients. The education on risk factors should be provided in the in the preconception period and throughout pregnancy. There are several components of educational practice that may improve the knowledge of pregnant individuals. The educational components can be divided into implementations during the antenatal period and the …

Reassessing Nitrogen Management For Maize Production In Mississippi, Camden Dawson Oglesby

Theses and Dissertations

12 N treatments in 2020 and 11 in 2021 were replicated four times over four locations in a randomized complete block design. The first research tested the efficacy of CYG for Mississippi corn (Zea mays L.) production. The optimum N rates were calculated by fitting four models. Differences between the CYG rate and AONR were compared. AONR varied from 134 to 301 kg N ha–1 at different management levels. When we compared the AONR to the CYG rate, the CYG rate over-recommended N in 12 of the 14 possible comparisons. The second study compared different VIs, methods, and sensors at …