Digital Commons Network^™

Campus Updates And Improvements For Fall 2022, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Uab Partnering To Battle Food Insecurity For Those Living With Hiv, Adam Pope

Browse All News

No abstract provided.

Food Insecurity And Depression Among Us Adults: Nhanes 2005–2016, Nicole Reeder, Terezie Tolar-Peterson, R. Hartford Bailey, Wen-Hsing Cheng, Marion W. Evans Jr.

Faculty Publications

A growing body of evidence suggests that food insecurity is associated with adverse mental health outcomes such as depression and anxiety. In this study, the relationship between food insecurity and depression was examined using data from the 2005–2016 National Health and Nutrition Examination Survey (NHANES). Food insecurity was assessed with the 18-item United States Food Security Survey Module with zero affirmative responses indicating high food security, 1 or 2 affirmative responses indicating marginal food security, and ≥3 affirmative responses indicating food insecurity. Depression was assessed with the Patient Health Questionnaire-9 with scores ≥10 indicating depression. Data were analyzed from 28,448 …

Plants As A Source Of Anticancer Agents: From Bench To Bedside, Wamidh H. Talib, Safa Daoud, Asma Ismail Mahmod, Reem Ali Hamed, Dima Awajan, Sara Feras Abuarab, Lena Hisham Odeh, Samar Khater, Lina T. Al Kury

All Works

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in cancer. In this review, we discussed the anticancer activities of ten natural products extracted from plants. The …

A Sampling, Exposure And Receptor Framework For Identifying Factors That Modulate Behavioural Responses To Disturbance In Cetaceans, Cormac G. Booth, Naomi Brannan, Rebecca Dunlop, Ari Friedlander, Saana Isojunno, Patrick Miller, Nicola Quick, Brandon Southall, Enrico Pirotta

School of Biological and Marine Sciences

No abstract provided.

Athletics

DePaul Magazine

Courting Community: Former Blue Demons star Kevin Edwards gives his all for alumni; Aneesah Morrow Takes College Basketball World By Storm; Javon Freeman-Liberty Fires Up Blue Demon Hopes; BIG EAST's Fastest Rising Volleyball Program; Track and Field Teams Shine at BIG EAST Indoor Championships

Maternal Iron Deficiency Programs Rat Offspring Hypertension In Relation To Renin-Angiotensin System And Oxidative Stress, Ya-Hui Chang, Wan-Hsuan Chen, Chung-Hao Su, Hong-Ren Yu, You-Lin Tain, Li-Tung Huang, Jiunn-Ming Sheen

Faculty, Staff and Student Publications

Hypertension is an important public health challenge, affecting up to 30-50% of adults worldwide. Several epidemiological studies indicate that high blood pressure originates in fetal life-the so-called programming effect or developmental origin of hypertension. Iron-deficiency anemia has become one of the most prevalent nutritional problems globally. Previous animal experiments have shown that prenatal iron-deficiency anemia adversely affects offspring hypertension. However, the underlying mechanism remains unclear. We used a maternal low-iron diet Sprague Dawley rat model to study changes in blood pressure, the renal renin-angiotensin system, oxidative stress, inflammation, and sodium transporters in adult male offspring. Our study revealed that 16-week-old …

Scoping Review: Scope Of Practice Of Nurse‐Led Services And Access To Care For People Experiencing Homelessness, Lucy Mcwilliams, Martha Paisi, Sandy Middleton, Jill Shawe, Anna Thornton, Matthew Larkin, Joanne Taylor, Jane Currie

School of Nursing and Midwifery

No abstract provided.

Missouri Alot - Dc Experience, Amy Bax

Title III Professional Development Reports

I want to thank Lincoln University for sponsoring this trip. I had access to many high-level people in DC that wanted to hear my story of agriculture. These are people that have the power to create legislative practices and policies that are favorable to the agricultural industry. I had the opportunity to advocate for Lincoln and Lincoln University students.

Expansions In The U.S. Child Care And Development Block Grant Improved Program Stability, Hyojeong Kim, Colleen Heflin, Taryn Morrissey

Population Health Research Brief Series

Child care is necessary for most parents to work and serves as an important developmental context for children. Yet many low-income families struggle with the high cost of child care. The child care subsidy program is designed to help low-income working families pay for child care. In 2018, Congress substantially increased funding for child care through the Child Care and Development Block Grant (CCDBG) to states, enabling them to make improvements to their child care subsidy programs. This brief summarizes the policy changes made in Virginia and describes how those changes improved child care subsidy stability and participation in that …

Sweet Taste Signaling: The Core Pathways And Regulatory Mechanisms, Sunil Kumar Sukumaran, Salin Raj Palayyan

Department of Nutrition and Health Sciences: Faculty Publications

Sweet taste, a proxy for sugar-derived calories, is an important driver of food intake, and animals have evolved robust molecular and cellular machinery for sweet taste signaling. The overconsumption of sugar-derived calories is a major driver of obesity and other metabolic diseases. A fine-grained appreciation of the dynamic regulation of sweet taste signaling mechanisms will be required for designing novel noncaloric sweeteners with better hedonic and metabolic profiles and improved consumer acceptance. Sweet taste receptor cells express at least two signaling pathways, one mediated by a heterodimeric G-protein coupled receptor encoded by taste 1 receptor members 2 and 3 (TAS1R2 …

Targeting De Novo Lipogenesis And The Lands Cycle Induces Ferroptosis In Kras-Mutant Lung Cancer, Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I Wistuba, John D Minna, Jeffrey G Mcdonald, Pier Paolo Scaglioni

Faculty, Staff and Student Publications

Mutant KRAS (KM), the most common oncogene in lung cancer (LC), regulates fatty acid (FA) metabolism. However, the role of FA in LC tumorigenesis is still not sufficiently characterized. Here, we show that KMLC has a specific lipid profile, with high triacylglycerides and phosphatidylcholines (PC). We demonstrate that FASN, the rate-limiting enzyme in FA synthesis, while being dispensable in EGFR-mutant or wild-type KRAS LC, is required for the viability of KMLC cells. Integrating lipidomic, transcriptomic and functional analyses, we demonstrate that FASN provides saturated and monounsaturated FA to the Lands cycle, the process remodeling oxidized phospholipids, such as PC. Accordingly, …

The Impact Of The Covid-19 Pandemic On Patients With Chronic Liver Disease: Results From The Global Liver Registry, Zobair M. Younossi, Yusuf Yilmaz, Mohamed El-Kassas, Ajay Duseja, Saeed Hamid, Gamal Esmat, Nahum Méndez-Sánchez, Wah Kheong Chan, Ashwani K. Singal, Brian Lam

Department of Medicine

Patients with preexisting chronic liver disease (CLD) may experience a substantial burden from both coronavirus 2019 (COVID-19) infection and pandemic-related life disruption. We assessed the impact of the COVID-19 pandemic on patients with CLD. Patients enrolled in our Global Liver Registry were invited to complete a COVID-19 survey. As of June 2021, 2500 patients (mean age ± SD, 49 ± 13 years; 53% men) from seven countries completed the survey. Of all survey completers, 9.3% had COVID-19. Of these patients, 19% were hospitalized, 13% needed oxygen support, but none required mechanical ventilation. Of all patients including those not infected with …

Two Courts, Two Conclusions: Abortion Law In India, Gauri Pillai

Popular Media

On 15 July 2022, the Delhi High Court, in Ms X v The Principal Secretary of Health and Family Welfare Department Government of NCT of Delhi (‘Ms X’), denied an unmarried woman permission to terminate her unwanted pregnancy at 23 weeks under Section 3 of the Medical Termination of Pregnancy Act, 1971. A week later, through an ad-interim order, the Supreme Court allowed the woman’s appeal against the Delhi High Court’s order, permitting termination as long as a Medical Board confirms that abortion is medically safe for the pregnant woman. In this post, I discuss both these orders, which differ …

Persistent Ethnicity-Associated Disparity In Anti-Tumor Effectiveness Of Immune Checkpoint Inhibitors Despite Equal Access, Marcus A Florez, Jan O Kemnade, Nan Chen, Wendy Du, Anita L Sabichi, Daniel Y Wang, Quillan Huang, Courtney N Miller-Chism, Aparna Jotwani, Albert C Chen, David Hernandez, Vlad C Sandulache

Faculty, Staff and Students Publications

We reviewed response to immune checkpoint inhibitors (ICI) of 207 patients with diagnoses of lung or head and neck cancer treated with chemotherapy/ICI combination therapy and ICI monotherapy between 2015 and 2020 at one of three clinical pavilions associated with the Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine. Two of these pavilions (Harris Health System and the Michael E. DeBakey Veterans Affairs Medical Center) serve large minority populations and provide equal access to care regardless of means. 174 patients had a diagnosis of lung cancer (non-small cell or small cell) and 33 had a diagnosis of …

An Integrated Proteomic And Glycoproteomic Investigation Reveals Alterations In The N-Glycoproteomic Network Induced By 2-Deoxy-D-Glucose In Colorectal Cancer Cells, Cheng Ma, Hong-Yuan Tsai, Qi Zhang, Lakmini Senavirathna, Lian Li, Lih-Shen Chin, Ru Chen, Sheng Pan

Faculty, Staff and Students Publications

As a well-known glycolysis inhibitor for anticancer treatment, 2-Deoxy-D-glucose (2DG) inhibits the growth and survival of cancer cells by interfering with the ATP produced by the metabolism of D-glucose. In addition, 2DG inhibits protein glycosylation in vivo by competing with D-mannose, leading to endoplasmic reticulum (ER) stress and unfolded protein responses in cancer cells. However, the molecular details underlying the impact of 2DG on protein glycosylation remain largely elusive. With an integrated approach to glycoproteomics and proteomics, we characterized the 2DG-induced alterations in N-glycosylation, as well as the cascading impacts on the whole proteome using the HT29 colorectal cancer …

Qualifying Factors That Predict Weight Loss Success Within Diet Interventions, Jordan Losavio

LSU Master's Theses

Evidence-based diet strategies lead to weight loss for some, while for others, the same diet approach could result in trivial weight loss or even in weight gain. This prompts the underlying research question: what factors predict that a given diet strategy will be efficacious for some, but not for others? This research was a secondary analysis of clinical weight loss studies to determine which factors influence an individual’s weight loss success for three diet intervention strategies: low-carbohydrate, low-fat, and low-calorie. A combination of physiological, psychological, behavioral, and dietary factors was evaluated for each diet study. Multiple linear regression and logistic …

Heart Failure In General And Cardiac Transplant Patients With Covid-19, Munish Sharma, Gowthami Sai Kogilathota Jagirdhar, Kalpalatha K Guntupalli, Rahul Kashyap, Salim Surani

Faculty, Staff and Students Publications

Coronavirus disease 2019 (COVID-19) is primarily an infection of the respiratory tract, but it can have multisystem manifestations. Cardiac complications of COVID-19 can range from acute myocardial injury, cardiac arrhythmias, or heart failure, amongst others. Heart failure (HF) in COVID-19 can be a de novo process or due to worsening of pre-existing cardiovascular ailment. HF in a patient with COVID-19 not only poses challenges in clinical presentation and management of COVID-19 but also affect prognosis of the patient. This article aims to succinctly revisit the implications of this pandemic regarding pre-existing HF or new-onset HF based on prevailing data. It …

Laudanum And Lavender: Patent Medicines Prescribed To 19th Century American Women, Nat Pendergraft

Voces Novae

No abstract provided.

Lisdexamfetamine Is An Effective Monotherapy For Moderate To Severe Binge Eating Disorder, Benjamin Young

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using

McElroy SL, Hudson J, Ferreira-Cornwell MC, Radewonuk J, Whitaker T, Gasior M. Lisdexamfetamine dimesylate for adults with moderate to severe binge eating disorder: Results of two pivotal phase 3 randomized controlled trials. Neuropsychopharmacology. 2016;41(5):1251-1260. https://doi.org/10.1038/npp.2015.275

for a young woman requesting a novel pharmacological intervention for a Binge Eating Disorder (BED).

Enhanced Recovery After Surgery (Eras) Protocols Decrease Length Of Hospital Stay And Maintain Functional Independence In Elderly Patients Undergoing Colorectal Surgery, Kristen Hawes

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using

Ostermann S, Morel P, Chalé JJ, et al. Randomized controlled trial of enhanced recovery program dedicated to elderly patients after colorectal surgery. Dis Colon Rectum. 2019;62(9):1105-1116. https://doi.org/10.1097/DCR.0000000000001442

for an elderly patient undergoing colorectal surgery.

2022 Student Research Fellowship Program: Serf Abstract Booklet, Tyler Braley, Erin Jefferson Do, Brian Henriksen Phd, Mph, Camden Bohn Bs, Jason Li Bs, Noah Todd Bs, Jessica Pater Phd, Jeanne Carroll Rn, Gabriella Cunningham, John Morton Ccp, Hannah Copeland Md Facs Facc, Jay Fiechter, Micah Smith Md, Katrina Fliotsos, Michael Gerue Rn, Msn, David Sowden Md, Carly Daley Phd, Isaac Kipfer Bs, Thein Zhu Mbbs, Face, Frcp, Lisa Hollister Rn, Dnp, Dazar Opoku Mph, Fenlei Chang Md, Phd, Leah J. Peipert, James Kraatz Md, Abigail Russell, Susie Stace Rn, Cpn, Susie Allison Soldner Md, Dylan Schneider, Emily Keltner Bs, Ma, T. Eric White Md, Mariah Thomas, Julie Hunter, Asim Mohammed Md, Zixuan (Angela) Zhao, Ping-Chang Kuo, Barbara A. Scofield, Jui-Hung Jimmy Yen

Medical Student Research

2022 Abstracts Featured

Assessing the Impact of Physician Pain on Motivation to Provide Longitudinal Osteopathic Manipulative Therapy to Patients and its Correlation to Opioid Prescribing: A Cohort Study

Predicting Cognitive Decline in Long-COVID Patients: A Demographic and Comorbid Analysis Using BrainCheck Cognitive Assessment

The Use of Anticoagulants in COVID-19 Positive Patients on Extracorporeal Membrane Oxygenation

A Mineralized Allograft in Lumbar Interbody Fusion – A Retrospective Chart Review Study

Creating a Patient Registry for the Parkview Vein Clinic

Traumatic Brain Injury in a Level II Trauma Center Network Serving Rural Northeastern Indiana: A Cross-Sectional Study

Peripheral Neuropathy in Long-COVID Patients: Demographic …

A Retrospective Analysis Of Endocrine Disease In Sphingosine-1-Phosphate Lyase Insufficiency: Case Series And Literature Review, Avinaash Maharaj, Ruth Kwong, Jack Williams, Christopher Smith, Helen Storr, Ruth Krone, Debora Braslavsky, Maria Clemente, Nanik Ram, Indraneel Banerjee

Section of Diabetes, Endocrinology and Metabolism

Sphingosine-1-phosphate lyase (SGPL1) insufficiency syndrome (SPLIS) is an autosomal recessive multi-system disorder, which mainly incorporates steroid-resistant nephrotic syndrome and primary adrenal insufficiency. Other variable endocrine manifestations are described. In this study, we aimed to comprehensively annotate the endocrinopathies associated with pathogenic SGPL1 variants and assess for genotype-phenotype correlations by retrospectively reviewing the reports of endocrine disease within our patient cohort and all published cases in the wider literature up to February 2022. Glucocorticoid insufficiency in early childhood is the most common endocrine manifestation affecting 64% of the 50 patients reported with SPLIS, and a third of these individuals have additional …

Generous Donors Make Gardner-Webb Masters-Melton Indoor Baseball Facility A Reality, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb continues to celebrate fundraising successes and those who choose to support and advance the University. A GWU benefactor, whose legacy of giving energized the men’s baseball program, made another significant gift to the sport he loved so much. Bill Masters, who passed away on June 25, 2022, gave the lead gift for the Masters-Melton Indoor Baseball Facility, also named in honor of his longtime special friend, Patsy Melton Willis.

Determinants Of Delayed Initiation Of Breastfeeding: A Cross-Sectional Multicenter Study In Abu Dhabi, The United Arab Emirates, Zainab Taha, Aysha Ibrahim Al Dhaheri, Ludmilla Wikkeling-Scott, Ahmed Ali Hassan, Dimitrios Papandreou

All Works

One of the best practices to reduce the risk of infant morbidity and mortality is the early initiation of breastfeeding, specifically within the first hour of birth, as the World Health Organization (WHO) recommends. Limited data exist on breastfeeding initiation and its related factors in the United Arab Emirates (U.A.E.). Therefore, the purpose of this research study was to evaluate and analyze the determinant factors associated with delayed initiation of breastfeeding among mothers with children aged <2 years old in a cross-sectional multicenter setting in Abu Dhabi, U.A.E. Seven governmental community and healthcare centers participated in the study from diverse geographic areas of Abu Dhabi. A trained female research assistant collected information from mothers with young children attending the centers. All participants were informed in detail about the purpose of the study and signed a written consent form. A total of 1610 mother-child pairs were included in the study. The mean (standard deviation) of maternal age and children's age was 30.1 (5.1) years and 8.1 (5.9) months, respectively. Six hundred and four (604) (37.5%) reported delayed initiation of breastfeeding. Factors associated with delayed breastfeeding initiation were being of non-Arab nationality (adjusted odds ratio (A.O.R.) 1.30, 95% confidence interval (CI) 1.03, 1.63), caesarean section (AOR 2.85, 95% CI 2.26, 3.58), non-rooming-in (AOR 2.82, 95% CI 1.53, 5.21), first birth order (AOR 1.34, 95% CI 1.07, 1.69), and mothers with low-birth-weight children (AOR 3.30, 95% CI 2.18, 4.99) as was analyzed by multivariate logistic regression analysis. In conclusion, approximately four out of ten mothers delayed initiation of breastfeeding for more than one hour after delivery. The results of this study call for urgent policy changes to improve the early initiation rates of breastfeeding mothers in the U.A.E.

The Biological Activity Of Tea Tree Oil And Hemp Seed Oil, Lakatos Lakatos, Samuel Obeng Apori, Julie Dunne, Furong Tian

Articles

The interest in hemp seed oil (HSO) and tea tree oil (TTO) in the medical and food industries is increasing. The current study compares their bioactivity to other plant oils, mainly focusing on hemp seed oils (HSOs) with various cannabidiol (CBD) contents. A DPPH assay was employed to evaluate the antioxidant activity. The antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Salmonella enteritidis was evaluated using time–kill, minimum inhibition concentration (MIC), and Kirby–Bauer disk diffusion methods. Tea tree oil showed significantly higher antimicrobial activity against S. enteritidis compared to E. coli and S. aureus (p < 0.05). The antioxitant activity range (lowest to highest) was sesame < vetiver < rosehip < tea tree < organic hemp < pure hemp < 5% CBD < vitamin C. Tea tree oil and 5% CBD showed antioxidant activity at IC50 of 64.45 μg/mL and 11.21 μg/mL, respectively. The opposing antimicrobial and antioxidant results for TTO and HSO indicate that these activities arise from different components within the oil compositions.

Examining Demographic And Environmental Factors In Predicting The Perceived Impact Of Cancer On Childhood And Adolescent Cancer Survivors, Nazan Cetin

Dissertations and Theses

Cancer survivors' perceptions on how cancer has impacted their lives has been identified as a "critical predictor" of psychosocial well-being and quality of life outcomes. Given the dramatic increase in survival rates and the long-term health and psychosocial challenges, as well as survivorship care barriers, this study focuses special attention on childhood and adolescent cancer survivors and is guided by Tedeschi and Calhoun's theory of posttraumatic growth and Hammond's theory of distinctiveness. This study aims to examine the influence of demographic (i.e., age at diagnosis, biological sex, race/ethnicity, type of cancer) and environmental factors (i.e., geographical location and insurance type), …

Integration Of Remote Sensing Approaches For In-Season Nitrogen Management, Murilo De Santana Martins

LSU Doctoral Dissertations

Nitrogen (N) management is being conducted at flat rate in Louisiana due to practicality and convenience, but the price of N fertilizer and high breakeven costs are forcing producers to find ways to reduce costs and optimize N application. In this scenario, precision agriculture technologies, specifically the use of optical sensors on board of unmanned aerial systems (UAS) to variable rate N application on farm is showing a promising approach to save inputs and reduce environmental impacts. However, the general goal of this research was to develop and evaluate in-season N management approaches for N recommendation in corn (Zea …

Econometric Analysis Of The Relationship Between Domestic Economic Growth And Levels Of Inflow Of Remittances In Developing Countries, Mihail Naskovski

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

The international global migration has produced an exponential growth of remittances, which can be defined as the transfer of funds from one country to another. This study will inspect the macroeconomic impact of remittance inflow on economic growth using panel regression, covering the period from 1981 to 2020 and focusing on a sample of 152 countries, then filtered by 4 geographical regions for additional analysis. Like many studies before, a consensus about an overall effect of the flows on global level could not be reached from his study following the analysis of the general sample. However, on a more specific …

Early Childhood Intervention And Income Inequality: An Analysis On The Intergenerational Mobility Of Head Start Participants, Paul Hinton

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

The Head Start program is an early childhood intervention program funded by the federal government. Designed for low-income families, it promotes school readiness among its participants. In my research, I examine the effects of Head Start on the intergenerational mobility of its participants. Using data from the National Longitudinal Survey of Youth (NLSY79) and the NLSY Child and Young Adult Supplement (CNLSY), I measure the degree of earnings persistence between parents and their children for students in preschool and Head Start. I find that participation in Head Start is associated with an increase in mobility, which remains true after controlling …