Physiological Regulation Of Annual Life History Events In Adult Female Weddell Seals, Amy Lorraine Kirkham

Fisheries

Predicting the impacts of environmental changes on animal populations requires a comprehensive understanding of the life history and physiological ecology of organisms in the wild, including the precise timing and regulation of annual biological events. In this dissertation, I assess how intrinsic factors including serum hormone concentrations and nutritional status relate to the critical annual events of reproduction, seasonal foraging, and pelage molt in an Antarctic marine predator, the Weddell seal (Leptonychotes weddellii). A large component of these assessments are comparisons between female Weddell seals that pupped in the current season (postpartum females) and females that have pupped in the …

The Core-Kdt Study: A Mixed Methods Protocol To Establish Core Outcomes For Refractory Childhood Epilepsy Treated With Ketogenic Diet Therapy, Jennifer H. Carroll, J. Helen Cross, Mary Hickson, Emma Williams, Valerie Aldridge, Avril Collinson

School of Health Professions

Abstract Background A core outcome set defines the minimum outcomes that should be included in clinical trials, audit or practice. The aim being to increase the quality and relevance of research by ensuring consistency in the measurement and reporting of outcomes. Core outcome sets have been developed for a variety of disease states and treatments. However, there is no established set of core outcomes for refractory childhood epilepsy treated with ketogenic diet therapy. This should be developed using a patient-centred approach to ensure the outcomes measured are relevant to patients and clinical practice. Methods This is a mixed methods study …

Ronald E. Mcnair Scholars Program Profiles And Abstracts 2022, Motutama Sipelii

McNair Symposium

This is the complete event program and provides presentation abstracts and biographies of McNair scholars and their mentors.

Development And Validation Of A Simple Model To Predict The Risk Of Nonmelanoma Skin Cancer On Screening Total Body Skin Examination, Rebecca Hartman, Yun Xue, Ryan Karmouta, Elizabeth Tkachenko, Sara J. Li, David G. Li, Cara Joyce, Arash Mostaghimi

Biostatistics Collaborative Core: Faculty Publications and Other Works

Objective. There is insufficient evidence to generate skin cancer screening guidelines at the population level, resulting in arbitrary variation in patient selection for screening skin examinations. This study was aimed at developing an easy-to-use predictive model of nonmelanoma skin cancer (NMSC) risk on screening total body skin examination (TBSE).

Methods. This epidemiologic assessment utilized data from a prospective, multicenter international study from primarily academic outpatient dermatology clinics. Potential predictors of NMSC on screening TBSE were identified and used to generate a multivariable model that was converted into a point-based scoring system. The performance characteristics of the model were validated in …

Heritable Vaginal Bacteria Influence Immune Tolerance And Relate To Early-Life Markers Of Allergic Sensitization In Infancy, Kathryn E. Mccauley, Elze Rackaityte, Brandon Lamere, Douglas W. Fadrosh, Kei E. Fujimura, Ariane R. Panzer, Din L. Lin, Kole V. Lynch, Joanna Halkias, Ventura F. Mendoza, Trevor D. Burt, Casper Bendixsen, Kathrine Barnes, Haejin Kim, Kyra Jones, Dennis R. Ownby, Christine C. Johnson, Christine M. Seroogy, James E. Gern, Homer A. Boushey, Susan V. Lynch

Allergy & Immunology Articles

Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy and asthma risk in childhood, observations hypothetically linked by intergenerational microbial transmission. Using maternal vaginal (n = 184) and paired infant stool (n = 172) samples, we identify four compositionally and functionally distinct Lactobacillus-dominated vaginal microbiota clusters (VCs) that relate to prenatal maternal health and exposures and infant serum immunoglobulin E (IgE) status at 1 year. Variance in bacteria shared between mother and infant pairs relate to VCs, maternal allergy/asthma status, and infant IgE levels. Heritable bacterial gene pathways associated with infant IgE …

Critical Access Hospital Nurses' Qualitative Reports Of Major Obstacles In End-Of-Life Care, Con K. Newman

Theses and Dissertations

Background: Critical Care Nurses have previously noted obstacles in caring for dying patients. Obstacles noted by nurses working in more urban settings have been reported. What is not known is the obstacles to providing end-of-life (EOL) care as perceived by nurses working in Critical Access Hospitals (CAHs). Objective: To determine the stories/experiences related to obstacles in providing EOL care as reported by nurses working in CAHs. Methods: This was an exploratory, cross-sectional study. Previous quantitative data has been reported. Documentation of the qualitative stories/experiences of nurses working in CAHs related to obstacles to providing EOL care for dying patients and …

Exploring New Jersey Public And Public Charter School Nurses' Knowledge Levels And Perceptions Of Food Allergies In Schools: A Mixed Methods Study, Lorelei Lorissa Cheli-Voorhees

Theses and Dissertations

The number of children affected by food allergies in the United States is large and increasing. The potential for life-threatening food-induced allergic reactions presents significant risks for students and schools. In the state of New Jersey, nurses are responsible for managing the risks associated with food allergies in elementary and secondary schools. The purpose of this mixed methods study was to explore and understand the knowledge, perceptions, policies, and practices of New Jersey public school nurses towards food allergies in schools. The participants were certified school nurses who currently work in public and public charter elementary and secondary schools in …

Targeting The Maladaptive Effects Of Binge Drinking On Circadian Gene Expression, Courtney Ledford

University Honors Theses

Previous studies 1) support a role of circadian genes in regulating alcohol intake, and 2) reveal that harmful alcohol use alters circadian rhythms. However, there [is] minimal knowledge of the effects of chronic alcohol processes on rhythmic circadian gene expression across brain regions important for circadian biology and alcohol intake. Therefore, the present study sought to test the effects of chronic binge-like drinking on diurnal circadian gene rhythms in the master circadian pacemaker (SCN), the ventral tegmental area (VTA), and the nucleus accumbens (NAc) in High Drinking in the Dark-1 (HDID-1) mice, a unique genetic risk model for drinking to …

The Global Network Socioeconomic Status Index As A Predictor Of Stillbirths, Perinatal Mortality, And Neonatal Mortality In Rural Communities In Low And Lower Middle Income Country Sites Of The Global Network For Women's And Children's Health Research, Archana B. Patel, Carla M. Bann, Cherryl S. Kolhe, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Lester Figueroa, Nancy F. Krebs, Fabian Esamai, Sarah Saleem

Community Health Sciences

Background: Globally, socioeconomic status (SES) is an important health determinant across a range of health conditions and diseases. However, measuring SES within low- and middle-income countries (LMICs) can be particularly challenging given the variation and diversity of LMIC populations.
Objective: The current study investigates whether maternal SES as assessed by the newly developed Global Network-SES Index is associated with pregnancy outcomes (stillbirths, perinatal mortality, and neonatal mortality) in six LMICs: Democratic Republic of the Congo, Guatemala, India, Kenya, Pakistan, and Zambia.
Methods: The analysis included data from 87,923 women enrolled in the Maternal and Newborn Health Registry of the NICHD-funded …

Immuno-Genomic Profiling Of Biopsy Specimens Predicts Neoadjuvant Chemotherapy Response In Esophageal Squamous Cell Carcinoma, Shota Sasagawa, Hiroaki Kato, Koji Nagaoka, Changbo Sun, Motohiro Imano, Takao Sato, Todd A Johnson, Masashi Fujita, Kazuhiro Maejima, Yuki Okawa, Kazuhiro Kakimi, Takushi Yasuda, Hidewaki Nakagawa

Faculty, Staff and Student Publications

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is primarily treated with platinum-based neoadjuvant chemotherapy (NAC). Some ESCCs respond well to NAC. However, biomarkers to predict NAC sensitivity and their response mechanism in ESCC remain unclear. We perform whole-genome sequencing and RNA sequencing analysis of 141 ESCC biopsy specimens before NAC treatment to generate a machine-learning-based diagnostic model to predict NAC reactivity in ESCC and analyzed the association between immunogenomic features and NAC response. Neutrophil infiltration may play an important role in ESCC response to NAC. We also demonstrate that specific copy-number alterations and copy-number …

Endocrine Disrupting Chemical Exposure In Feminine Hygiene Products And The Effect On The Menstrual Cycle, Elizabeth Aguirre

Master's Projects and Capstones

Endocrine disrupting chemicals have been associated with a variety of harmful effects on the human body such as affecting the development, reproductive, neurological, cardiovascular, metabolic and immune systems. There are many sources that can contribute to human exposure, but some sources are not as intensely researched as others. This paper aims to identify feminine hygiene products as a source of exposure to endocrine disrupting chemicals to consumers. There are few studies that have examined these products and the levels of endocrine disrupting chemicals exposure through them. Feminine hygiene products are used globally and by many different ages. It is important …

The Rationale For The Utilization Of Under Desk Bikes In Office Settings, Danielle Little

Masters Theses, 2020-current

Inactivity and sedentary behavior are major health concerns, exacerbated by the amount of time individuals spend at work. Purpose: To examine if 30-60 minutes of daily under-the-desk bicycle (UDB) use while working for 8 weeks helped sedentary and physically inactive adults reach the U.S. physical activity guidelines (PAG) and improve perceptions of wellness and job satisfaction. Methods: Subjects (n=22, average age=45.3 yrs, average BMI=30.2 kg/m2) cycled for 30-60 minutes on workdays for 8-weeks at a self-selected intensity level of 2 or 3 out of 8 total levels. Participants were advised not to engage in additional physical activity outside the study …

The Impact Of Color Of Artificial Led Lighting On Microgreen: A Review, Envry Artanti Duidahayu Putri, Hauzan Ariq Musyaffa Fajri, Firstina Iswari, Fadlan Atalla Muhammad, Rossita Fauziah, Rahmat Budiarto

Jurnal Kultivasi

Microgreen is an emerging agricultural food product that its development can be close type system and rely on the presence of artificial lighting, such as LED. Present study aimed to sum up the artificial LED lighting impact on microgreen production. In general, there were three important variables of light for plant, i.e., light intensity, light duration/photoperiod and light quality. The effect of different LED color on microgreen yield and phytochemical content is also revealed in present review. The red, blue, combination of red and blue, green, white, yellow and UV-A light are numerous choice for optimal microgreen production. However, there …

Improving Donor Bank Milk Administration Workflow In The Neonatal Intensive Care Unit, Davelyn M. Moffit

Master's Projects and Capstones

_Abstract

Problem: Improvement in the donor bank milk (DBM) administration workflows is required to reduce documentation errors and discrepancies. Increased awareness of errors and their impact on quality, safety, and risk management is imperative to optimize clinical, operational, and financial outcomes, as well as a hospital’s reputation.

Context: Research shows human milk is beneficial to the growth of premature and medically-diagnosed term infants. Regulatory agencies recommend standards and guidelines to handle human milk and to monitor compliance and safety practices of healthcare organizations.

Intervention: An audit tool and process map were created to internally monitor the current process for DBM …

A One Health Approach: Addressing The Overuse Of Antibiotics In Agriculture, Abby Erin Anderson

Master's Projects and Capstones

Antimicrobial resistance (AMR) has emerged as one of the leading public health threats of the 21^st century (Naghavi, 2022). AMR occurs due to an evolution of bacteria, making treatments of bacterial infections less effective (Naghavi, 2022). In recent years, several publications began identifying a linkage between antibiotic use in agriculture to humans. Roughly 70% of all antibiotics in the United States are being used in animal feed (Cable, 2018). More than 2.8 million antibiotic-resistance infections occur in the United States every year- which results in roughly 35,000 deaths (CDC, 2019). A comprehensive analysis estimated nearly 1.27 million deaths globally …

The Global Network Socioeconomic Status Index As A Predictor Of Stillbirths, Perinatal Mortality, And Neonatal Mortality In Rural Communities In Low And Lower Middle Income Country Sites Of The Global Network For Women's And Children's Health Research, Archana B Patel, Carla M Bann, Cherryl S Kolhe, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Lester Figueroa, Nancy F Krebs, Fabian Esamai, Sherri Bucher, Sarah Saleem, Robert L Goldenberg, Elwyn Chomba, Waldemar A Carlo, Shivaprasad Goudar, Richard J Derman, Marion Koso-Thomas, Elizabeth M Mcclure, Patricia L Hibberd

Global Health Articles

BACKGROUND: Globally, socioeconomic status (SES) is an important health determinant across a range of health conditions and diseases. However, measuring SES within low- and middle-income countries (LMICs) can be particularly challenging given the variation and diversity of LMIC populations.

OBJECTIVE: The current study investigates whether maternal SES as assessed by the newly developed Global Network-SES Index is associated with pregnancy outcomes (stillbirths, perinatal mortality, and neonatal mortality) in six LMICs: Democratic Republic of the Congo, Guatemala, India, Kenya, Pakistan, and Zambia.

METHODS: The analysis included data from 87,923 women enrolled in the Maternal and Newborn Health Registry of the NICHD-funded …

Covid-19 Newsletter (Vol. 132), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Elucidating Factors Affecting Cercosporin Production In Cercospora Leaf Blight Of Soybean To Develop Better Tools For Disease Management, Maria Izabel Costa De Novaes

LSU Doctoral Dissertations

Fungal toxins are pathogenicity/virulence factors for many plant diseases, including Cercospora leaf blight (CLB) of soybean (Glycine max (L.) Merr.). The pathogen, Cercospora cf. flagellaris, produces a perylenequinone toxin, cercosporin, which is activated by light to produce damaging reactive oxygen species. To identify novel solutions for CLB management, we studied factors that may impact the biology of cercoporin: fungal lipid droplets (LDs) and mineral and trace element composition (ionome) of the host. Furthermore, since artificial inoculation with the pathogen has been challenging, we also explored the usefulness of a previously developed cercosporin-based assay to study disease resistance. LDs …

Racial Inequality, Covid-19, And Health And Unemployment Insurance: Lessons Learned And Pathways Forward, Shauhin A. Talesh

DePaul Law Review

No abstract provided.

Energy Cost Of Reclining, Sitting, And Standing Activities In Chinese Adults, Jiajia Liu, Yiyan Li, Minghui Quan, Jie Zhuang, Zhen-Bo Cao, Zheng Zhu, Yongming Li, Stephen D. Herrmann, Barbara E. Ainsworth

International Journal of Exercise Science

International Journal of Exercise Science 15(7): 1202-1211, 2022. The 2011 Compendium presents MET values for sedentary behaviors (SBs) and light-intensity physical activities (LIPAs). Some entries have estimated METs, others have multiple activities in a single entry, and newer activities are not in the Compendium. Accurate MET values are needed to increase the validity and generalizability of the Compendium. This study measured and analyzed SBs and LIPAs’ energy costs in reclining, sitting, standing postures, and fidgeting. Indirect calorimetry measured the energy costs (VO₂, ml^.kg^-1.min^-1) in 11 males and seven females (30.7 ± 7.6 …

The Effects Of A Multi-Ingredient Supplement On Various Cognitive Measures, Jason M. Curtis, Cassandra Evans, Veronica Mekhail, Paulina Czartoryski, Juan Carlos Santana, Jose Antonio

Journal for Sports Neuroscience

The purpose of this study was to investigate the effects of a multi-ingredient pre-workout supplement (MIPS) on mental and physical performance. Seventeen exercise-trained men (n = 7) and women (n=10) completed this randomized, placebo-controlled, double-blind, counterbalanced, crossover trial. Participants consumed either a multi-ingredient pre-workout supplement (MIPS) or a placebo in a randomized, counterbalanced order. Forty-five minutes post-consumption, the following assessments were conducted: psychomotor vigilance test (PVT), Profile of Mood States (POMS), Stroop test, vertical jump test, and a Cold pressor test. There was a one-week washout period between assessments. There were significant differences in the incongruent task for the Stroop …

Environmental And Occupational Health Risks: Educating Undergraduate Student Nurses For Best Practice, Dorinda A. Mercado

DNP Qualifying Manuscripts

The environments we inhabit, whether homes, schools, workplaces, or the communities that envelop them, are replete with ubiquitous health risks that we routinely ignore to avoid analysis paralysis from worries. Environmental risks are hidden in food, drink, household and personal care products, furniture, and building materials; chemical hazards and physical residues of modern living contaminate air, water, and soil. Occupational hazards are prevalent in workplaces as diverse as agriculture, highways, and hospitals. A recent study by the Centers for Disease Control and Prevention (2022) found that out of 2,310 urine samples taken from a group of Americans from the United …

Digital Agriculture In Africa: An Ethnographic Study Of Global Online Networking And Resource Mobilization On Mfangano Island, Ian James Muir Smith

Senior Theses

In one of the most isolated parts of Kenya, on an island in Lake Victoria, small-scale farmers are using newfound internet access in a unique and innovative way. New Information and Communication Technologies (ICTs) are transforming agriculture around the world, and due to a political, infrastructural, and entrepreneurial environment conducive to ICT innovation, Kenya leads the African continent in this field, known in the media as “Digital Agriculture”. In the face of the climate crisis and environmental degradation, people living on and around Mfangano Island are using self-managed volunteering platforms, crowdfunding sites, and social media in order to network with …

Air Quality Impacts From Mineral Dust, Fireworks, And Urban Pollution Revealed By Trace Element Chemistry And Strontium Isotopes Ratios In The Wasatch Front, Utah, Usa, Micah J. Marcy

Theses and Dissertations

Airborne particulate matter (PM) in urban areas is derived from a combination of natural and anthropogenic sources. To identify PM sources and their effects on air quality, we collected PM using active filter samplers over a two-year period in the urban Wasatch Front, northern Utah, an area affected by multiple pollution sources. Filters from active samplers and other PM samples were analyzed for major and trace element concentrations and 87Sr/86Sr ratios. We identified wind-blown mineral dust from dry lake beds, winter inversions, and fireworks as primary PM sources affecting air quality in the Wasatch Front. Dust contributes Al, Be, Ca, …

Spatio-Temporal Changes In Vegetation In The Last Two Decades (2001–2020) In The Beijing–Tianjin–Hebei Region, Yuan Zou, Wei Chen, Siliang Li, Tiejun Wang, Le Yu, Min Xu, Ramesh P. Singh, Cong-Qiang Liu

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

In terrestrial ecosystems, vegetation is sensitive to climate change and human activities. Its spatial-temporal changes also affect the ecological and social environment. In this paper, we considered the Beijing–Tianjin–Hebei region to study the spatio-temporal vegetation patterns. The detailed analysis of a moderate-resolution imaging spectroradiometer (MODIS) data were carried out through the Google Earth Engine (GEE) platform. Our results show a slow and tortuous upward trend in the average leaf area index (LAI) in the study region for the periods 2001–2020. Specifically, Beijing had the highest LAI value, with an average of 1.64 over twenty years, followed by Hebei (1.30) and …

Re-Analysis And Additional Information Needed To Inform Conclusions Comment On Halenova Et Al Deuterium-Depleted Water As Adjuvant Therapeutic Agent For Treatment Of Diet-Induced Obesity In Rats, Colby J Vorland, Xiwei Chen, Daniella E Chusyd, Luis M Mestre, Stephanie L Dickinson, David B Allison, Andrew W Brown

Children’s Nutrition Research Center Staff Publications

We were interested to read the report by Halenova et al. [...].

Development Of A Medication Reconciliation Policy In Outpatient Mental Health Facility, Karen E. Webster

DNP and Student Works

Adverse drug events and medication discrepancies are patient safety challenges for patients and healthcare professionals. Medication errors result in approximately 7000 deaths annually, and adverse drug events harm 1.5 billion people and cost $3.5 billion annually (Dunham & Makoul, 2008). Medication reconciliation can significantly decrease medication errors. "It involves obtaining, verifying and documenting the patient's current medicines and comparing to their medication orders and the patient's condition to identify and resolve any discrepancies" (Duguid, 2012, p. 15). The deliberate time taken to complete medication reconciliation plays a significant role in patient care, along with increasing the quality of care provided. …

Gray And White Matter Abnormality In Patients With T2dm-Related Cognitive Dysfunction: A Systemic Review And Meta-Analysis, Teng Ma, Ze-Yang Li, Ying Yu, Bo Hu, Yu Han, Min-Hua Ni, Yu-Xiang Huang, Hao-Han Chen, Wen Wang, Lin-Feng Yan, Guang-Bin Cui

Faculty, Staff and Student Publications

Aims/hypothesis

Brain structure abnormality in patients with type 2 diabetes mellitus (T2DM)-related cognitive dysfunction (T2DM-CD) has been reported for decades in magnetic resonance imaging (MRI) studies. However, the reliable results were still unclear. This study aimed to make a systemic review and meta-analysis to find the significant and consistent gray matter (GM) and white matter (WM) alterations in patients with T2DM-CD by comparing with the healthy controls (HCs).

Methods

Published studies were systemically searched from PubMed, MEDLINE, Cochrane Library and Web of Science databases updated to November 14, 2021. Studies reporting abnormal GM or WM between patients with T2DM-CD and …

Understanding Control Of Metabolite Dynamics And Heterogeneity, Christopher John Hartline

McKelvey School of Engineering Graduate Student Theses & Dissertations

Microbes live in complex and continually changing environments. Rapid shifts in nutrient availability are a common challenge for microbes, and cause changes in intracellular metabolite levels. Microbial response to dynamic environments requires coordination of multiple levels of cellular machinery including gene expression and metabolite concentrations. This coordination is achieved through metabolic control systems, which sense metabolite concentrations and direct cellular activity in response. Several reoccurring control architectures are found throughout diverse metabolic systems, which suggests underlying evolutionary advantages for using these control systems to coordinate metabolism. One common, yet understudied, control architecture is the positive feedback metabolite uptake loop, which …

Ligand- And Strain-Specific Control Of Microbial Communities, Austin Grant Rottinghaus

McKelvey School of Engineering Graduate Student Theses & Dissertations

Microbes naturally coexist in complex, multi-strain communities that are valuable assets for their host. Commensal and probiotic microbes prevent pathogen colonization, reduce the frequency and severity of various ailments, provide essential nutrients, and offer various additional benefits. Understanding the dynamics of and tailoring microbial communities to provide additional beneficial functions is a primary focus of researchers in medicine and agriculture. To date, consortia have primarily been manipulated by supplementing the communities with microbes that were engineered in vitro or by introducing stimuli that alter the metabolism or composition of the community. This method has proven successful, with numerous microbes engineered …