Digital Commons Network^™

Hepatocyte-Hepatic Stellate Cell Axis In Potentiation Of Alcohol And Hiv-Induced Liver Injury, Moses O. New-Aaron

Theses & Dissertations

Human Immunodeficiency Virus (HIV) remains a global threat, with approximately 38.4 million active infections and 33 million HIV-related deaths since the first case. While many may be tempted to think of HIV as a relic of the past, emerging data suggests otherwise. By the end of 2021, approximately 1.5 million HIV incidences and 650 000 mortalities were reported globally. The etiologies of HIV-related mortality are numerous. Liver disease is one of the leading etiologies of HIV-related mortality, especially in recent times of antiretroviral therapy (ART)-induced longevity among people living with HIV (PLWH). While co-infections with hepatotropic viruses notoriously contribute to …

An Analysis Of The Genetic And Environmental Mechanisms Behind Aortic Aneurysm Development And Inhibition, Kathryn E. Jespersen

Theses & Dissertations

Aortic aneurysm is a widespread condition, characterized by dilation and weakening of the aortic vessel wall. Dissection and rupture of the aorta due to uncontrolled aneurysm progression carries a high risk of death. Although both thoracic aortic aneurysms (TAA) and abdominal aortic aneurysms (AAA) share similar risks of rupture and mortality, the pathophysiology of each disease is unique. TAA is a hallmark feature of Marfan syndrome (MFS), a connective tissue disorder characterized by malformation of functional elastic fibers in the aortic extracellular matrix (ECM). This malformation of elastic fibers is attributed to mutation of the gene encoding the fibrillin-1 protein, …

Metoprolol Disrupts Sterol Biosynthesis Through Inhibition Of 7-Dehydrocholesterol Reductase (Dhcr7), Luke B. Allen

Theses & Dissertations

Cholesterol is essential for life. It is particularly important in the brain as it relies on de novo synthesis of cholesterol following the formation of the blood brain barrier (BBB). As such, disrupting sterol biosynthesis during neurodevelopment can have devastating outcomes. The most common post-lanosterol sterol biosynthesis disorder, Smith-Lemli-Opitz Syndrome, arises from a faulty DHCR7 enzyme. DHCR7 has also been shown to be inhibited by several psychotropic medications. Here we assess six beta-blockers and their effects on sterol biosynthesis in vitro. Two beta-blockers, metoprolol and nebivolol strongly inhibit DHCR7 in four separate in vitro models of both mouse and …

The Art Of Branding: Rebranding The Habit, Allison Willrich

Whittier Scholars Program

The world is more visual-oriented than ever before, making a company’s logo a crucial factor in the success of branding as the logo serves as the first impression and visual indicator of the experience and value the brand will deliver. The purpose of this project is to better understand how people respond to brand design, and more specifically make judgments about the company based on the first impression they get from a logo. The brand of focus is The Habit, an American restaurant chain recognized for its excellence in product quality, but also has weaknesses in its overall brand negatively …

Variation In The M-Opioid Receptor (Oprm1) And Offspring Sex Are Associated With Maternal Behavior In Rhesus Macaques (Macaca Mulatta), Zachary Baron

Theses and Dissertations

A m-opioid receptor (OPRM1) single-nucleotide-polymorphism, found in both humans and rhesus macaques mediates the mother-infant attachment bond. Because mothers treat their sons and daughters differently, it is somewhat surprising that the role of infant sex has not been assessed in the context of a maternal-OPRM1-genotype-by-infant-sex interaction. The present study investigates the effect of maternal-OPRM1-genotype and infant sex on mother-infant behaviors. Over the first six months of offspring life, mother-infant behavioral data assessing attachment quality was collected twice weekly from a large number of rhesus monkey mother-infant pairs (N=161 dyads; n=64 female infants, n=97 male infants). Mothers were genotyped for OPRM1 …

The Relationship Between P66shc Expression And Proliferation Of Human Prostate Cancer Cells With Mntnbuoe-2-Pyp Treatment, Thao Nhi Radik

Theses & Dissertations

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the U.S. in men, mainly due to the development of castration-resistant PCa (CRPC). MnTnBuOE-2-PyP⁵⁺ (BuOE), a superoxide dismutase (SOD) mimic, inhibits human PCa cell proliferation through hydrogen peroxide (H₂O₂). p66Shc protein level is upregulated in CRPC and is associated with cell proliferation in PCa cells.We propose that the different sensitivity of those PCa cells to BuOE could be due to the expression levels of p66Shc protein.

Our data showed that PCa cells that expressed high levels of p66Shc are more resistant to BuOE …

Engagement Journalism In Action: Supporting New Yorkers With Long Covid, Sarah Luft

Capstones

What do asthma and long COVID have in common? 1 in 13 U.S. adults are living with them. This report is a recap of my efforts to address the information needs of New Yorkers with long COVID as a student in CUNY's Craig Newmark Graduate School of Journalism engagement program. For my final project, I partnered with THE CITY, a nonprofit news outlet serving New Yorkers, to expand the MISSING THEM project. The report details the what, why, and how of my engagement reporting process, including a community engagement framework, a service journalism series, and lessons to carry forward. You …

Nyc Vendor Voices - Highlighting The Voices Of Nyc Street Vendors, Hafeezat A. Bishi

Capstones

NYC Vendor Voices is an amalgamation of the reporting and content creation work I've done over the past 8 months about street vendors of NYC. The street vendor community of New York City is vast with over 20,000 members. There are vendors in all five boroughs, and they range from a variety of backgrounds from West Africa to North Africa to India. My work includes links to my reporting, data/content creation I've done in my coding class, as well as the social media content I've done and continue to work on.

Careers Lost To Long Covid, Emily Sauchelli

Capstones

Americans have had to adjust to new lifestyles as a result of the lingering symptoms associated with long COVID. Many have had no choice but to leave the workforce. Those with long COVID are putting the career paths they intended for themselves behind them, due to their inability to keep up with their jobs as a result of their lingering symptoms. Accommodations and resources on how those with long COVID can reenter back into the workforce are coming at a slow pace, as employers are not recognizing how to help those with long COVID stay and thrive in the workplace. …

Increasing Hpv Vaccination In Adolescents, Emily Martin, Emily Hartmann

Doctor of Nursing Practice Projects

Human papillomavirus virus (HPV) is a sexually transmitted disease that can negatively affect both males and females by leading to cervical, vaginal, vulvar, anal, penile, and oropharyngeal cancer. Vaccinating against HPV using the Gardasil vaccine is an effective method to prevent HPV, however, vaccination rates are still unacceptably low in adolescents ages 11 to 14. Pediatric providers should encourage and strongly recommend HPV vaccines to all adolescents. Addressing and easing parental hesitancy is a key component to improving vaccine acceptance. The setting for the project was a rural pediatric office in southern Illinois where HPV vaccination rates are lower than …

Assessment Of Caregiver Burden In A Memory Loss Clinic, Andrea Perkins

Doctor of Nursing Practice Projects

Background: Over 131,000 people in Illinois identify themselves as caregivers of someone with memory loss. The family caregiver may provide care including, but not limited to, assistance with activities of daily living, financial responsibilities, behavior management, and scheduling, and transportation to medical appointments. The care provided by the caregivers may lead to caregiver burden symptoms of depression, anxiety, and perceived stress. Purpose: Health care providers at a central Illinois memory clinic are not currently completing formal assessments of caregiver burden. This quality improvement project was done to determine if the current memory loss program services provide enough support …

Utilizing Remote Sensing Technology To Relocate Lubra Village And Visualize Flood Damages, Ronan Wallace

Mathematics, Statistics, and Computer Science Honors Projects

As weather patterns change worldwide, isolated communities impacted by climate change go unnoticed and we need community and habitat-conscious solutions. In Himalayan Mustang, Nepal, indigenous Lubra village faces threats of increasing flash flooding. After every flood, residual concrete-like sediment hardens across the riverbed, causing the riverbed elevation to rise. As elevation increases, sediment encroaches on Lubra’s agricultural fields and homes, magnifying flood vulnerability. In the last monsoon season alone, the village witnessed floods swallowing several fields and damaging two homes. One solution considers relocating the village to a new location entirely. However, relocation poses a challenging task, as eight centuries …

The Power Of Anime: Artistic Power, Social Consciousness, And Cultural Impact, Natalie Ortez-Arevalo

Master's Projects and Capstones

This project explores the widespread popularity and impact of anime on Japanese culture. In my research, I demonstrate how the integration of anime into Japan’s culture creates big splashes—like stones being thrown into a lake—that, at the same time, ripple out in various directions and reverberate on multiple levels. First and foremost, this research centers around an important concept: that anime contains well-crafted storytelling and powerful imagery that demonstrates wider historical, cultural, and social issues—both the positive and negative. In anime films and shows, symbolism plays an important part as it can be found throughout the imagery and the storylines …

Peru: Moving Upstream To Improve Adolescent's Mental Health, Rathmony Van-Ramirez, Rathmony Van-Ramirez

Master's Projects and Capstones

Mental health disorders can emerge at any age, with incidence prevalent in childhood and young adulthood. The cost associated with mental health negatively impacts both personally and economically. The consequences of these impacts are long-lasting and spill over into households and communities. Adolescence is a unique and formative time. Physical, emotional, and social changes, including exposure to poverty, abuse, or violence, can make adolescents vulnerable to mental health problems. Protecting adolescents from adversity, promoting socio-emotional learning and psychological well-being, and ensuring access to mental health care are critical for their health and well-being during adolescence and adulthood (World Health Organization …

Usp<800> Hazardous Drug Safe-Handling In The Medical-Surgical Microsystem: A Cnl Quality Improvement Project, Ananda T. Le

Master's Projects and Capstones

Problem: The USP General Chapter <800> guidelines protect healthcare workers from hazardous drugs (HD) and are enforceable by hospital regulatory organizations. Hospitals should increase their safe handling and administration of these drugs to be compliant and protect their workers. This quality improvement project aimed to improve nurse compliance with the safe handling of USP <800> drugs on the medical-surgical microsystem within 16 weeks.

Context: This clinical nurse leader (CNL) quality improvement project was implemented on two medical-surgical microsystems in a San Francisco Bay Area hospital system.

Interventions: The team conducted passive observational data collection and active observation in the form of a …

Crispr Technology As An Antiviral In Dsdna And Ssrna Viruses, Cathryn Mayes

Theses & Dissertations

The COVID-19 pandemic highlights the necessity of emergency response and pandemic preparedness, especially for emerging viral threats. Currently, virus-specific vaccines and antivirals are the primary tools to combat viral diseases; however, broad-spectrum antivirals that target more than one virus species could provide additional protection from emerging and re-emerging viral diseases (Andersen et al. 2020; Zhu et al. 2015; Hickman et al. 2022).

Clustered regulatory interspaced short palindromic repeat (CRISPR)-associated endonucleases have become recently utilized as potential antiviral strategies due to their high specificity, efficacy, and versatility (Najafi et al. 2022). While CRISPR-based antivirals have previously been used to target specific …

Characterization Of Ape1 And Dna G-Quadruplex Interaction In Transcription Regulation And Dna Damage Repair, Suravi Pramanik

Theses & Dissertations

Human AP Endonuclease 1 (APE1) is the primary enzyme in the base excision repair (BER) pathway that repairs apurinic/apyrimidinic (AP) sites, the most frequently formed DNA lesions in the genome. Recently, through genome-wide mapping analysis, we have shown that APE1, as well as its post-translationally modified form, acetylated APE1 (AcAPE1), is enriched in the gene regulatory regions. The APE1/AcAPE1-enriched regions also harbor Guanine (G)-rich sequences that fold into DNA secondary structures called G-quadruplexes (G4s). Our lab has demonstrated a strong genome-wide correlation between the occurrence of G4 structures and the binding of APE1 and AcAPE1. However, it is unknown whether …

A Cell Culture Model To Study Tobacco Associated Oral Cancer Progression And Treatment Resistance, Amanda Busch

Theses & Dissertations

Head and Neck Squamous cell carcinoma is the 6^th most common cancer in the world. Risk factors for HNSCC include alcohol and tobacco consumption, infection with Human Papilloma Virus, and exposure to environmental toxins. Unlike many other cancers, the incidence of HNSCC is growing, yet the treatment options and outcomes have not been significantly improved for decades. An increased understanding of the molecular mechanisms of these cancers is needed for improvement in early diagnosis, enhanced treatment effectiveness, and cancer prevention. 4-nitroquinoline 1-oxide (4NQO) is a well-tested, tobacco mimicking, carcinogen. 4NQO produces similar histological and chemical changes found in human …

The Influence Of Predation Environment On The Sensory Ecology Of Brachyrhaphis Rhabdophora, Alexandra Grace Duffy

Theses and Dissertations

Across the animal kingdom, predation is a ubiquitous and omnipresent selective agent for a variety of traits. I aimed to address gaps in our knowledge pertaining to how predation shapes animal behavior. Many species of fish naturally occur in drainages that differ in the density of predators and exhibit obvious population divergence, making them ideal study organisms to investigate predator-driven behavioral evolution. In Chapter 1, I conducted a systematic review of the literature. The purpose of this review was to determine if predation acted as a stronger or weaker selective agent on particular behavioral traits (e.g., foraging, mating, antipredator etc.) …

After Being Ignored, Autistic Adults Find Their Place On The Spectrum, Leonardo A. Lopez Carreno

Capstones

Autistic adults have been historically ignored by researchers and clinical psychologists when discussing autism spectrum disorder. But the broadening of the diagnosis requirements for the disorder, as well as the perspectives from autistic adults that have been shared on social media, have made it so that autistic adults are being discussed more now than ever before, both in the autism community and among professionals in the field. This project puts together interviews with autistic people who have found communities online and in person, as well as the perspectives of researchers who have published studies about autism.

https://medium.com/@leonardolpezcarreo/after-being-ignored-autistic-adults-find-their-place-on-the-spectrum-6e131fc00796

Tiktok: A Path To Stardom… Sort Of, Giselle G. Medina

Capstones

“TikTok: A Path to Stardom… Sort of” delves deep into one of the top social media apps. TikTok has gone beyond just being the “new vine,” becoming a marketing tool, whether for yourself or a product. This package will address going viral on the app and what it means to be a full-time content creator through gifs, an audio documentary, written words, and of course... TikToks.

https://gisellemedina.github.io/TikTok-A-Path-To-Stardom...-Sort-of/

New York Set High Sights On A Progressive Retail Weed Industry. But The State Now Stands To Fall Short., Trina Mannino

Capstones

Almost a year-and-a-half after New York legalized recreational marijuana, state officials and other industry insiders praise what they view as the country's most socially equitable cannabis industry. But as New York prepares to launch its legal retail dispensary program, rollout details remain murky. The state also faces challenges with the legal industry’s most significant obstacle: illicit sales. If the state doesn’t deliver an equitable and robust market, New York risks winding up with a sputtering legal industry that could cause harm to the very people and communities it intends to lift up.

Link: https://trinamannino9.wixsite.com/mannino-mckinney

Limpieza De Asbestos En La Ciudad De Nueva York, Ariana G. Perez-Castells

Capstones

This is the story of how asbestos is removed in New York City, and who carries out the work. It's unclear how much more asbestos abatement is left in the county, and the U.S. has not completely banned the dangerous material, unlike over 50 other countries across the world. Both of these things could change soon. A new study that the U.S. Environmental Protection Agency will carry out by December 2024 would give us a better picture of how much asbestos there is still in buildings and how much more removal work is to be done. At the same time, …

Some In Corporate America Have Followed Through On Their Commitments To The Black Lives Matter Movement, But The Black Community Has Yet To Be Convinced., Brianna M. Monsanto

Capstones

Nearly three years following George Floyd's murder back in 2020, corporations are continuing to follow up on their commitments to the Black community. However, the Black community has yet to be impressed.

Link to Project: https://briannamonsanto64.wixsite.com/cuny

New York Running, Kellen Bulger

Capstones

My community is the New York City running community. This includes everyone from casual joggers to high school track athletes to folks training for an ultramarathon. The community also encompasses all five boroughs. For my community practicum project, I plan to host my second event/run in the community, where we will discuss the overall state of the running community in NYC. The successes, shortcomings, frustrations, and whatever else is on our minds. As I did with the last event, the discussion that takes place after our run will be loosely structured around this community-wide callout I distributed in the spring …

The Tale Of Two Leagues: Is There A Wage Gap Between The Nba & Wnba, Isaiah D. Johnson

Capstones

This capstone takes a look at the differences between the National Basketball Association (NBA) and the Women's National Basketball Association (WNBA). The capstone looks to find any similarities and looks to see if there's truly a wage gap between the two professional leagues.

Reclaiming South Asian Beauty, Rizwana Zafer

Capstones

Shows like Never Have I Ever, Bridgerton, and Love Is Blind have put South Asian beauty at the forefront of American media. However, the increased popularity of these shows has also reignited an interest in the appropriation of South Asian beauty trends. Through their work in the beauty industry and social media, Arpita, Susana Mollick, and Soni Kohli are reclaiming South Asian beauty in the face of appropriation.

Link to capstone project:

https://medium.com/@rizwana.zafer81/reclaiming-south-asian-beauty-9d8484f00a14

Fighting For The Right To Dance In Nyc’S Public Parks, Caithlin Peña

Capstones

Kanami Kusajima is an ink dancer and street performer who dances and creates art at Washington Square Park. She’s also been clashing with the Park Enforcement Patrol officers, who patrol the area. Her attempts to create a safer space for her fellow performers brings to light the complicated rules and regulations as well as the obstacles street performers face on the daily. Link to capstone project: https://medium.com/@caithlin.pena53/fighting-for-the-right-to-dance-in-nycs-public-parks-2cab922d1a1c

Pixel Predicament, Francisco J. Lahoz

Capstones

If the art that affected you greatly in your youth was under the risk of fading away, wouldn't you do anything to preserve it? Gamers are tired of seeing the art of video games be neglected by their copyright holders and are making efforts to find, catalogue, and preserve their artform in multiple ways.

https://flahoz.com/2023/01/24/pixel-predicament/

The Experiences Of Nyc's Social Equity Cannabis Initiative, Jimmie J. Mckinney Ii

Capstones

This capstone is a photo essay on the experiences of NYS's dispensary licenses applicants as they make their bid to be one of the first legal dispensaries in the state. The priority was to give those who've been arrested for cannabis a chance to benefit from their conviction. Photography, print, and videography were incorporated in this project.

Here is a link to my capstone website: https://readymag.com/u2050520461/mckinneycapstone/