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Classical And Γδ T Cells Are Each Independently Sufficient To Establish Protection Against A Classical Strain Of Klebsiella Pneumoniae, Joseph J Mackel, Catherine Morffy Smith, Rachel K Wasbotten, Joy Twentyman, David A Rosen

2020-Current year OA Pubs

Infections with classical strains of the Gram-negative bacterium

Voting Behavior During Fda Medical Device Advisory Committee Panel Meetings, Amanda Maisel-Campbell, Daniel I Schlessinger, Arianna F. Yanes, Emir Veledar, Kelly A. Reynolds, Sarah A. Ibrahim, Bianca Y. Kang, Noor Anvery, Emily Poon, Murad Alam

2020-Current year OA Pubs

OBJECTIVES: During premarket review, the US Food and Drug Administration may ask its Medical Device Advisory Committee (MDAC) Panels to assess the safety and effectiveness of medical devices being considered for approval. The objective of this study is to assess the relationship, if any, between individual votes and Panel recommendations and: (1) the composition of Panels, specifically the expertise and demographic features of individual members; or (2) Panel members' propensity to speak during Panel deliberations.

METHODS: This was a retrospective cohort study of routinely collected data from voting members of MDAC panels convened between January 2011 to June 2016 to …

Internalization Of Appearance Ideals And Not Religiosity Indirectly Impacts The Relationship Between Acculturation And Disordered Eating Risk In South And Southeast Asian Women Living In The United States, Sonakshi Negi, Erik M Benau, Megan Strowger, Anne Claire Grammer, C Alix Timko

2020-Current year OA Pubs

Objective: Studies that examine disordered eating in samples of Asian individuals living in the United States frequently combine all individuals of Asian descent into a single group, which can obscure important differences between groups and their experiences of acculturation. The goal of the present study was to establish the relation of acculturation, internalization of appearance ideals, and religiosity as predicting body dissatisfaction and disordered eating in women of South and Southeast Asian (SSEA) descent.

Method: Women of SSEA descent (

Results: Direct paths from acculturation to both body dissatisfaction and disordered eating were not significant. Thin ideal internalization completely accounted …

Bsl2-Compliant Lethal Mouse Model Of Sars-Cov-2 And Variants Of Concern To Evaluate Therapeutics Targeting The Spike Protein, Mohanraj Manangeeswaran, Derek D C Ireland, Seth G Thacker, Ha-Na Lee, Logan Kelley-Baker, Aaron P Lewkowicz, Paul W Rothlauf, Marjorie Cornejo Pontelli, Louis-Marie Bloyet, Michael A Eckhaus, Mirian I Mendoza, Sean Whelan, Daniela Verthelyi

2020-Current year OA Pubs

Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading to successive waves of COVID19 infections despite an unprecedented mass vaccination necessitating continuous adaptation of therapeutics. Small animal models can facilitate understanding host-pathogen interactions, target selection for therapeutic drugs, and vaccine development, but availability and cost of studies in BSL3 facilities hinder progress. To generate a BSL2-compatible

Jiann-Ping Hsu College Of Public Health Magazine, Georgia Southern University

College of Public Health: News & Publications

• Message from the Dean: Stuart H. Tedders, PhD
• One-On-One: Marshall in Conversation with Aslan
• Alumni Feature: Improving the Body Art Industry
• Truth is Better than Fiction
• An Invisible Danger
• New Development Council
• The Period Equity Movement
• Averitt Award Winner and Together United
• Our Students Around the World
• Justice, Equity, Diversity & Inclusion
• Center for Addiction Recovery Making an impact: Scholarship recipient named
• Karl E. Peace Center for Biostatistics and Survey Research Working together: Biostatistics collaborations
• Center for Public Health Practice and Research Improving Health Outcomes
• Faculty and Students
• Office of Practice and Research
• College
• Photos

A Comparison Of 64cu-Labeled Bi-Terminally Pegylated A20fmdv2 Peptides Targeting Integrin Ανβ6, Truc T Huynh, Sreeja Sreekumar, Cedric Mpoy, Buck E Rogers

2020-Current year OA Pubs

Expression of epithelial-specific integrin α

Representation Learning On Heterogeneous Spatiotemporal Networks, Dakshak Keerthi Chandra

Doctoral Dissertations

“The problem of learning latent representations of heterogeneous networks with spatial and temporal attributes has been gaining traction in recent years, given its myriad of real-world applications. Most systems with applications in the field of transportation, urban economics, medical information, online e-commerce, etc., handle big data that can be structured into Spatiotemporal Heterogeneous Networks (SHNs), thereby making efficient analysis of these networks extremely vital. In recent years, representation learning models have proven to be quite efficient in capturing effective lower-dimensional representations of data. But, capturing efficient representations of SHNs continues to pose a challenge for the following reasons: (i) Spatiotemporal …

Numerical Simulation Study Of Gel Treatment For Conformance Control From Lab To Field, Jianqiao Leng

Doctoral Dissertations

“Gel treatment has been widely applied to control reservoir conformance and thus improve the sweep efficiency of injection fluids. Quite a few numerical simulations have been conducted to investigate the factors impacting gel treatment and assist to optimize treatment design and predict the performance. However, there exists significant barrier between the simulation approaches and lab experiments. In this study, two comprehensive reviews have been conducted to identify the gaps between lab and current simulations for in-situ polymer treatment and preformed particle gel treatment, separately.

Based on the identified gaps, the effect of a few major factors which are very important …

Depression Of Pyrite In Polymetallic Sulfide Flotation Using Chitosan-Grafted-Polyacrylamide Polymers, Keitumetse Cathrine Monyake

Doctoral Dissertations

“In this work, Chitosan-grafted-Polyacrylamides (Chi-g-PAMs) were studied, for the first time, as selective depressants of pyrite in the flotation of base metal sulfides. Fundamental studies of the adsorption behavior of Chi-g-PAM on model sulfide minerals indicated that Chi-g-PAM was more selective to pyrite’s surfaces as compared to base metal sulfides. Results suggested that the adsorption of Chi-g-PAM at pyrite-water interface was a chemisorption in nature which involved the amine, amide, and hydroxyl groups of Chi-g-PAM. Batch flotation studies of complex sulfide ore of Mississippi Valley Type (MVT) showed that Chi-g-PAM outperformed other pyrite’s depressants at producing less pyrite-diluted concentrates. Statistical …

Mechanical Properties Of Boride Based Ceramics, Alec Murchie

Doctoral Dissertations

“This research focuses on the elevated mechanical properties of diboride based materials at room and elevated temperatures. These materials include a ZrB₂ ceramic, a ZrB₂-WC-SiC ceramic, and a (Hf,Mo,Nb,Ta,W,Zr)B₂ high entropy boride (HEB). The room temperature flexural strength for the ZrB₂ ceramic was 447 MPa and the fracture toughness was 2.3 MPa·m^1/2. The strength decreased to 196 MPa at 1800°C, and then increased to 360 MPa at 2300°C. The fracture toughness increased to 3.1 MPa·m^1/2 at 2200°C. The strength up to 1800°C was likely controlled by a combination of effects: surface damage …

Array Signal Processing For Source Localization And Enhancement, Sohel J. Patel

Doctoral Dissertations

“A common approach to the wide-band microphone array problem is to assume a certain array geometry and then design optimal weights (often in subbands) to meet a set of desired criteria. In addition to weights, we consider the geometry of the microphone arrangement to be part of the optimization problem. Our approach is to use particle swarm optimization (PSO) to search for the optimal geometry while using an optimal weight design to design the weights for each particle’s geometry. The resulting directivity indices (DI’s) and white noise SNR gains (WNG’s) form the basis of the PSO’s fitness function. Another important …

Characterization And Modeling Of Esd Events, Risk And Protection, Jianchi Zhou

Doctoral Dissertations

“The ESD (Electrostatic discharge) failures have been raising critical reliability problems in electronic devices design. However, not all the ESD scenarios have been specified by the IEC standard and the characterizations of the ESD risk for different scenarios are essential to evaluate the ESD robustness of the devices in the real word.

The insulation of plastic enclosures provides protection against ESD to the electronic system inside. However, seams between plastic parts are often unavoidable. Different plastic arrangements are constructed to investigate the spark length and current derivatives and to understand the ESD spark behavior for geometries having spark lengths longer …

Evaluation Of Recrosslinkable Preformed Particle Gel (Rppg) As A Fluid Loss Control Material During Drilling Operations, Mohamed Saad M. Ahdaya

Doctoral Dissertations

"One of the most intense, expensive, and time-consuming problems during drilling operations is the loss of circulation, which could result in several consequences, including wellbore collapse, fluid inflow, formation damage, environmental issues, and nonproductive time. This research aims to evaluate novel materials that can mitigate lost circulation and overcome the limitation of other materials. In this research, a comprehensive evaluation of a re-crosslinkable preformed particle gel (RPPG) has been conducted to determine the extent to which it can be used to control drilling fluid losses during drilling operations. The RPPG consists of swellable gel particles that can self-crosslink to form …

Design Methods For Pressure Relief Well Systems At Dams And Levees, Andrew Keffer

Doctoral Dissertations

"Flood risk reduction structures such as dams and levees are important systems that provide significant benefits to the nation. Relief wells reduce the substratum water pressures that can compromise them via internal erosion. The U.S. Army Corps of Engineers (USACE) analytical method to design relief well systems by calculating discharge and excess head along an infinite line of wells was developed from the 1930s – 1950s. The research presented here increases our understanding of the method’s history and uses analytical and numerical models to improve current infinite and finite well system design practices. The historical development of this method was …

Establishing Pteridine Metabolism In A Breast Cancer Cell Model And Quantification Of Silver Nanoparticle Interactions With Yeast Cells Using Mass Spectrometry, Lindsey Katherine Rasmussen

Doctoral Dissertations

"Recent advances in analytical methods have furthered the quantitative insights that can be gleaned from cellular analyses, with applications in cancer and nanoparticle research. In the first part of the research presented, a recently developed HPLC-MS/MS method was advanced to elucidate pteridine metabolism in an isogenic progressive MCF10A breast cancer cell model. The folate-derived pteridine pathway in breast cells was established by individually dosing cell cultures with folic acid and 15 pteridines. Eight potential pteridine biomarkers in breast cancer cells were identified including pterin and isoxanthopterin, which yielded the first in vitro evidence for the cellular metabolisms behind previously reported …

Development And Testing Of A New Air-Assisted Flare System For Low Flow Conditions, Hayder Alhameedi

Doctoral Dissertations

"Flare systems provide a safe, efficient, and reliable way to treat unwanted flammable gases that come from relief devices of various chemical processing equipment to ensure the safety of personnel and equipment. Flare systems are classified according to the assist media type as non-assisted (utility), steam-, air-, and pressure-assisted flares. The assist medium enhances mixing between flare gases and surrounding air and induces more air into the combustion zone. An air-assisted flare system is the preferred flare type in regions where steam is unavailable or is costly to supply or ambient temperatures are too low. The environmental protection agency (EPA) …

Data-Driven Modeling And Simulations Of Seismic Waves, Yixuan Wu

Doctoral Dissertations

"In recent decades, nonlocal models have been proved to be very effective in the study of complex processes and multiscale phenomena arising in many fields, such as quantum mechanics, geophysics, and cardiac electrophysiology. The fractional Laplacian(−Δ)^��/2 can be reviewed as nonlocal generalization of the classical Laplacian which has been widely used for the description of memory and hereditary properties of various material and process. However, the nonlocality property of fractional Laplacian introduces challenges in mathematical analysis and computation. Compared to the classical Laplacian, existing numerical methods for the fractional Laplacian still remain limited. The objectives of this research are …

Processing To Enable Direct-Write Additive Manufacturing Of Ceramics And Ceramic Composites, Austin Martin

Doctoral Dissertations

"This research focuses on the processing of novel feedstocks for and during direct-write additive manufacturing (AM), specifically the direct ink writing (DIW) and Ceramic On-Demand Extrusion (CODE) manufacturing processes, in order to produce ceramic and ceramic-based composite components. Strongly dispersed, concentrated (φ = 0.42), nanoparticle (d₅₀ ~0.3 µm), zirconia (ZrO₂) pastes were used to print densely filled, large continuous volume (≳ 1 cm³) ceramic components. An elastic shear modulus (G’) of 56,000 Pa and yield stresses between 6 and 10 Pa allowed for printed components of 34.5 mm in height over 115 layers without slumping …

Use Of Cellular Concrete For Air Convection Embankment To Protect Permafrost Foundation In Cold Regions, Hanli Wu

Doctoral Dissertations

"Crushed-rock air convection embankment (ACE) has been used to mitigate thaw settlement, and pavement distresses caused by climatic extremes in permafrost regions for over three decades. However, the desired crushed rocks needed for ACE are not readily available in many areas of interior Alaska. Burdened by the need to ship suitable rocks to remote locations, the cost of constructing an ACE is often prohibitively high, which prevents its wide use in Alaska. An existing cementitious material, cellular concrete, may provide the solution.

This study intends to systematically characterize the heat transfer patterns of ACE and identify the performance benefits of …

Secure And Efficient Information Management In Delay(Disruption) Tolerant Network, Shudip Datta

Doctoral Dissertations

"In environments like international military coalitions on the battlefield or multi-party relief work in a disaster zone, multiple teams are deployed to serve different mission goals by the command-and-control center (CC). They may need to survey damages and send information to the CC for situational awareness and also transfer messages to each other for mission purposes. However, due to the damaged network infrastructure in the emergency, nodes need to relay messages using the store and forward paradigm, also called Delay-tolerant Networks (DTNs). In DTN, the limited bandwidth, energy, and contacts among the nodes, and their interdependency impose several challenges such …

Computational Fluid Dynamics Techniques For Multiphase Flow Systems, Jose Sebastian Uribe Lopez

Doctoral Dissertations

"Mathematical modelling of multiphase flow systems has been a major and persistent challenge over the last decades. Vast attempts to obtain predictive models can be found reported in literature, where major advances can be recognized in recent years, paired to enhancements in computer science and engineering. Notwithstanding, universally valid models with a mechanistic development are far from being achieved. The current status of modelling any multiphase flow system relies on the model order reduction of purely theoretical models. Such reductions and simplifications become the source of deviations in the predictions of the experimentally measured parameters and will constrain the applicability …

Promoting Distributed Energy Deployment And Diffusion For Sustainable Civil Infrastructure Using Multi-Agent Based Modeling And Quantitative Analytics, Gasser Ali

Doctoral Dissertations

"Distributed Solar Generation (DSG) using small-scale Photo-Voltaic (PV) is an evolving technology with increasingly growing market penetration due to its significant benefits to consumers and broader power systems. DSG is sustainable, provides reliability, and is cost-effective where solar energy is abundant. However, the increasingly growing adoption of DSG creates uncertainties in forecasting electric power demand and market behavior. It also causes concerns of a “utility death spiral”. To this end, the goal of this research is to critically analyze the diffusion and benefits of DSG in the electric power infrastructure as a complex System-of-Systems (SoS). Specifically, this dissertation addresses the …

Far-End Crosstalk Modeling And Prediction For High-Speed Pcb Design With Inhomogeneous Dielectric Layers (Idls), Yuanzhuo Liu

Doctoral Dissertations

"Far-end crosstalk (FEXT) noise is a critical factor that affects signal integrity performance in high-speed systems. The FEXT level is sensitive to the inhomogeneity of the dielectric layers in fabricated printed circuit boards (PCB). The stripline is laminated by multiple inhomogeneous dielectric layers (IDL). The dielectric layers of the stripline are laminated with epoxy resin and glass bundles. The dielectric permittivity of the epoxy resin and glass bundles are different, which causes the inhomogeneity of the dielectric layers while also increasing the FEXT magnitude. The dielectric of the microstrip in printed circuit boards (PCB) fabrication usually consists of two layers: …

Application Of Machine Learning In Geophysics: Ranking Teleseismic Shear Wave Splitting Measurements And Classifying Different Types Of Earthquakes, Yanwei Zhang

Doctoral Dissertations

"During the past decades, applications of Machine Learning have been explosively developed to solve various academic and industrial problems, and over-human performance has been shown in diverse areas. In geophysical research, Machine Learning, especially Convolutional Neural Network (CNN), has been applied in numerous studies and demonstrated considerable potential. In this study, we applied CNN to solve two geophysical problems, ranking teleseismic shear splitting (SWS) measurements and classifying different types of earthquakes.

For ranking teleseismic SWS measurements, we utilized a CNN-based method to automatically select reliable SWS measurements. The CNN was trained by human-verified teleseismic SWS measurements and tested using synthetic …

Resistivity Imaging Of Prominent Seepage Pathways In Karst Terrain, Abdullah Hadi Zaid Alhaj

Doctoral Dissertations

"An integrated research approach was conducted to evaluate subsurface karstic conditions in Greene County, southwestern Missouri. Electrical resistivity tomography (ERT) was employed to image anomalously low resistivity zones associated with the presence of seepage pathways that were anthropogenic and/or natural in origin. Techniques including visual inspection (VI), multichannel analysis of surface waves (MASW), borehole control (BC), and aerial imagery (AI) were supplementally used to constrain the ERT data interpretations.

This research addressed six objectives. First, the ERT data interpretations were verified in terms of depth to the top of bedrock, fractures/voids, and moisture changes using the MASW, borehole control, and …

Investing In Late-Life Brain Capital, Walter D Dawson, Eric J Lenze, Et Al.

2020-Current year OA Pubs

Within many societies and cultures around the world, older adults are too often undervalued and underappreciated. This exacerbates many key challenges that older adults may face. It also undermines the many positive aspects of late life that are of tremendous value at both an individual and societal level. We propose a new approach to elevate health and well-being in late life by optimizing late-life Brain Capital. This form of capital prioritizes brain skills and brain health in a brain economy, which the challenges and opportunities of the 21st-century demands. This approach incorporates investing in late-life Brain Capital, developing initiatives focused …

Semi-Quantitative Assay To Measure Urease Activity By Urinary Catheter-Associated Uropathogens, Jesus M Duran Ramirez, Jana Gomez, Chloe L P Obernuefemann, Nathaniel C Gualberto, Jennifer N Walker

2020-Current year OA Pubs

Catheter-associated urinary tract infections (CAUTIs) are one of the most common healthcare-associated infections in the US, accounting for over 1 million cases annually and totaling 450 million USD. CAUTIs have high morbidity and mortality rates and can be caused by a wide range of pathogens, making empiric treatment difficult. Furthermore, when urease-producing uropathogens cause symptomatic CAUTI or asymptomatic catheter colonization, the risk of catheter failure due to blockage increases. The enzyme urease promotes catheter blockage by hydrolyzing urea in urine into ammonia and carbon dioxide, which results in the formation of crystals that coat the catheter surface. If CAUTI is …

Loss Of Function Of Wfs1 Causes Er Stress-Mediated Inflammation In Pancreatic Β-Cells, Shuntaro Morikawa, Lindsey Blacher, Chinyere Onwumere, Fumihiko Urano

2020-Current year OA Pubs

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and progressive neurodegeneration. Pathogenic variants in the

Gardnerella Exposures Alter Bladder Gene Expression And Augment Uropathogenic Escherichia Coli Urinary Tract Infection In Mice, Nicole M Gilbert, Valerie P O'Brien, Chevaughn Waller, Ekatherina Batourina, Cathy Lee Mendelsohn, Amanda L Lewis

2020-Current year OA Pubs

The anaerobic actinobacterium

2021-2022 Georgia Southern University Women's Basketball Media Guide, Georgia Southern University

Women's Basketball Records

• Georgia Southern Women's Basketball 2021-2022 Media Guide