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A Device That Facilitates Screwing At An Appropriate Angle In Quadrilateral Surface Fractures: 105-Degree Drill Attachment, Emre Gültaç, Cem Yalin Kilinç, Fati̇h İlker Can, İsmai̇l Gökhan Şahi̇n, Ahmet Emrah Açan, Çağatay Gemci̇, Nevres Hürri̇yet Aydoğan

Turkish Journal of Medical Sciences

No abstract provided.

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Medically Important Candida Spp. Identification: An Era Beyond Traditional Methods, Ebru Evren, Juli̇de Sedef Göçmen, Elvan Hortaç İştar, Şükran Yavuzdemi̇r, Fazil Alper Tekeli̇, Yasemi̇n Yavuz, Zeynep Ceren Karahan

Turkish Journal of Medical Sciences

No abstract provided.

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Classical Heart Rate Variability And Non-Linear Heart Rate Analysis In Mice Under Na-Pentobarbital And Ketamine/Xylazine Anesthesia., Hasan Kazdağli, Hasan Fehmi̇ Özel, Mustafa Özbek, Şüheda Alpay, Mürüvvet Alenbey

Turkish Journal of Medical Sciences

No abstract provided.

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Response To Letter To The Editor, Esra İşçi̇ Bostanci, Yasi̇n Durmuş, Si̇nem Ayşe Duru Çöteli̇, Fulya Kayikçioğlu, Nuretti̇n Boran

Turkish Journal of Medical Sciences

No abstract provided.

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Evidence-Based Information About Intermittent Fasting In Diabetes Patients: Useful Or Harmful?, Mustafa Altay

Turkish Journal of Medical Sciences

Background/aim: One of the most important components of treatment for diabetic patients is diet and healthy nutrition therapy. Calorie restriction is effective and without cost increases its appeal for both patients and physicians. Unfortunately, continuous calorie restriction is a difficult method. For this reason, alternative calorie restriction methods, such as intermittent fasting (IF), have been investigated by some researchers. Materials and methods: IF refers to a wide range of diet programmes covering periods of eating and fasting, which vary according to the different regimens. In this article, first, some general information will enable us to understand the concept of IF, …

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Remdesivir Treatment For Patients With Moderate To Severe Covid-19, İmran Hasanoğlu, Hati̇ce Rahmet Güner, İlhami̇ Çeli̇k, Fi̇kret Kanat, Ayşe Batirel, Gülçi̇n Telli̇ Di̇zman, Esma Eryilmaz Eren, Di̇lek Yildiz Sevgi̇, İlkay Bozkurt, Kadri̇ye Kart Yaşar, Sevtap Şenoğlu, Esra Kazak, Ridvan Karaali̇, Aysel Kocagül Çeli̇kbaş, Hüsnü Pullukçu

Turkish Journal of Medical Sciences

Background/aim: Remdesivir, which was first developed for the treatment of Ebola disease but failed to meet expectations, has become hope in the fight against the COVID-19 pandemic. This study aimed to evaluate risk factors for mortality and prognosis of adult moderate/severe COVID-19 patients treated with remdesivir, and safety and tolerability of 5 days of remdesivir treatment. Materials and methods: This multicenter prospective observational study was conducted in 14 centers in Turkey. Pregnancy or breastfeeding, multiorgan failure, or usage of vasopressors for septic shock, ALT > 5 × the upper limit of the normal range, or eGRF

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The Role Of Cd8+ Regulatory T Cells And B Cell Subsets In Patients With Covid-19, Hülya Uçaryilmaz, Di̇lek Ergün, Hüsametti̇n Vatansev, Hande Köksal, Onur Ural, Uğur Arslan, Hasi̇be Artaç

Turkish Journal of Medical Sciences

Background/aim: Coronavirus disease 2019 (COVID-19) has a wide clinical spectrum from asymptomatic to mild, moderate, and severe cases. There are still many unknowns about the role of immunoregulatory mechanisms in COVID-19. We aimed to study regulatory T cells (Tregs) and B cell subsets and evaluate their correlations with severity of COVID-19. Materials and methods: In total, 50 patients with COVID-19 confirmed by PCR (mean age = 49.9 ± 12.8 years) and 40 healthy control (mean age = 47.9 ± 14.7 years) were included in this study. The patients were classified as 14 mild (median age = 35.5 [24-73] years), 22 …

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Comparison Of Intraoperative Biliary Anastomosis Stenting Technique In Living-Donor Liver Transplantation: Review Of 41 Patients, Ramazan Dönmez, Şener Balas, Ufuk Utku Göktuğ, Ertan Emek, Yaman Tokat

Turkish Journal of Medical Sciences

Background/aim: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two different stenting methods used in biliary tract anastomosis in living-donor liver transplantation. Material and methods: We retrospectively analyzed data from 41 living-donor liver transplantations that were performed due to endstage liver failure between August 2019 and November 2020. Patients were grouped according to the stenting technique used in biliary anastomosis. Postoperative biliary tract complications were investigated. Results: Biliary fistulas were observed in 2 …

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Investigation Of Cochlear Microphonics Recorded With Different Stimulus Types, Özgecan Güneşer, Ayşe Arzu Yi̇ği̇t, Asuman Alniaçik, Kürşat Yanarateş, Eda Çakmak

Turkish Journal of Medical Sciences

Background/aim: Electrocochleography (ECochG), one of the first defined tests under auditory evoked potentials, is a total electrical response of inner and outer hair cells inside the cochlea and auditory nerve record technique to the presence of an acoustic stimulus. T hese records can be used in Meniere disease and auditory neuropathy spectrum disorder diagnosis, intraoperative monitoring. In addition, the presence of cochlear microphonics plays a crucial role in auditory neuropathy spectrum disorder diagnosis. In our study, healthy individuals were tested with extratimpanic electrocochleography record method via Click and LS CE-Chirp stimulus, and the results were compared to the age, sex, …

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The Role Of Vitamin D-Synthesizing Enzyme Cyp27b1 In Systemic Lupus Erythematosus, Man Luo, Jing Liu, Yeshuang Yuan, Yong Chen, Guohua Yuan

Turkish Journal of Medical Sciences

Background/aim: To measure the expression of 1α-hydroxylase (CYP27B1) and serum 25(OH)D concentration in systemic lupus erythematosus (SLE) and to investigate the role of CYP27B1 in SLE. Materials and methods: Seventy-seven SLE patients and 35 healthy controls (HCs) were enrolled from September 2017 to January 2020. T he study design is cross-sectional. mRNA expression of CYP27B1 in peripheral blood mononuclear cells (PBMCs) was measured by reverse-transcription quantitative PCR, the protein level of CYP27B1 was quantified by western blotting, and the serum level of 25(OH) D was determined by an enzyme-linked immunosorbent assay. Results: The mRNA expression of CYP27B1 in PBMCs was …

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Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir

Turkish Journal of Medical Sciences

Background/aim: Ultrasonography and fine-needle aspiration biopsy are frequently used to diagnose thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. This study investigated whether there is a relationship between thiol/ disulphide homeostasis and cytological and histopathological diagnosis of thyroid nodules. Materials and methods: The patient group consisted of 81 individuals with euthyroid nodular (single/multiple) goiter scheduled for thyroidectomy, and the control group consisted of 28 age- and sex-matched healthy volunteers who had no thyroid nodule on ultrasonographic evaluation. All participants were selected among the admissions to the study clinic between June 2017 and June 2018, and …

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Evaluation Of Subclinical Cardiovascular Disease By Carotid Intima Media Thickness, Epicardial Adipose Tissue Thickness, Serum Endocan, And Nesfatin-1 Levels In Patients With Primary Hyperparathyroidism, Muhammet Kocabaş, Yakup Alsancak, Mustafa Can, İlker Çordan, Hati̇ce Çalişkan Burgucu, Meli̇a Karaköse, Fatma Hümeyra Yerli̇kaya, Mustafa Kulaksizoğlu, Feri̇dun Karakurt

Turkish Journal of Medical Sciences

Background/aim: Data on the presence and extent of cardiovascular disease (CVD) risk in primary hyperparathyroidism (PHPT) are conflicting. In our study, we aimed to investigate the increased CVD risk in patients with PHPT by carotid intima-media thickness (CIMT), epicardial adipose tissue (EAT) thickness, and serum levels of endocan and nesfatin-1. Materials and methods: Patients with PHPT (n = 44) and age- and sex-matched healthy control subjects (n = 40) were enrolled in this study. Demographic data of the participants were questioned. Serum endocan and nesfatin-1 concentrations were assessed using commercially available ELISA kits. Noninvasive measurements of CIMT and EAT thickness …

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The Correlation Of Serum Spd-1 And Spd-L1 Levels With Clinical, Pathological Characteristics And Lymph Node Metastasis In Nonsmall Cell Lung Cancer Patients, Burcu Ancin, Mesut Meli̇h Özercan, Yi̇ği̇t Yilmaz, Serkan Uysal, Ulaş Kumbasar, Zeynep Saribaş, Erkan Di̇kmen, Riza Doğan, Meti̇n Demi̇rci̇n

Turkish Journal of Medical Sciences

Background/aim: Significant advances have been achieved in immunotherapy for the treatment of lung cancer. It is known that tumor cells and cells in the tumor microenvironment express high amounts of programmed cell death ligand 1 (PD-L1). These PD-L1s interact with programmed cell death protein 1 (PD-1), causing immunosuppression. The aim of our study is to examine the correlation between the serum sPD-1 and sPD-L1 levels and clinicopathological characteristics in patients with nonsmall cell lung cancer. We also compared our results with the healthy population (control group). Materials and methods: Thirthy-seven nonsmall cell lung cancer (NSCLC) patients who were operated in …

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The Effect Of Immunonutrition On Tumor Infiltrative T Lymphocytes And Regulatory T Cells In Rectal Tumor Patients Receiving Neoadjuvant Chemoradiotherapy: A Prospective Randomized Clinical Study, Mehmet Onur Gül, Cebrai̇l Akyüz, Selvi̇naz Özkara

Turkish Journal of Medical Sciences

Background/aim: The rationale behind using immunonutrition in cancer patients is to prevent malnutrition, manage the host's immune response, and keep cancer under control by utilizing the potential immune system available in the host against the tumor. This prospective- study aims to assess the impact of immunonutrition on tumor-infiltrating lymphocytes (TILs) and regulatory T cells (Tregs) in rectal cancer patients receiving neoadjuvant chemoradiotherapy. Materials and methods: This is a single-center, prospective study. Forty patients diagnosed with middle and lower rectal tumors were enrolled in the study between March 2018 and December 2019. Nutrition protocols were given to all study subjects prior …

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Effect Of Perioperative Factors On The Prognosis Of Patients With Hepatocellular Carcinoma Who Underwent Hepatectomy, Lining Xu, Yingying Xu, Guiping Li, Bo Yang

Turkish Journal of Medical Sciences

Background/aim: Hepatic resection is a potentially curative treatment for patients with hepatocellular carcinoma (HCC). Controversy persists regarding preoperative and intraoperative characteristics related to patient survival in various medical institutes. This study aimed to evaluate the impact of preoperative and intraoperative factors on the long-term survival of patients with HCC who underwent hepatectomy. Materials and methods: Data on 455 patients with HCC who underwent hepatectomy over a 20-year period were retrospectively reviewed. Univariate and multivariate Cox regression analyses were performed for preoperative- and intraoperative-related prognostic factors. Results: The 1-, 3-, 5-, and 10-year overall survival rates of patients with HCC who …

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Morbid Obesity Leads To Increased Skin Autofluorescence Independent Of Metabolic Syndrome Components, Tuğçe Apaydin, Di̇lek Yavuz

Turkish Journal of Medical Sciences

Background/aim: Obesity, diabetes mellitus, and metabolic syndrome (MetS) are associated with increased accumulated skin advanced glycation end products. We aimed to evaluate the association of MetS components with skin autofluorescence (SAF) in patients with morbid obesity. Material and methods: Eight hundred and one patients with morbid obesity and 94 age-matched controls with normal body mass index (BMI) and normal glucose metabolism were included. Advanced glycation end products (AGEs) were measured using SAF in the forearm, with an AGE reader. Results: The prevalence of MetS in patients with morbid obesity was 65.5% (n = 525). Type 2 diabetes mellitus (type 2 …

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Predictors Of Lymphovascular Invasion In Estrogen Receptor Positive/Her-2 Negative Breast Cancer Patients Treated With Neoadjuvant Chemotherapy, Eyyüp Çavdar, Yakup İri̇ağaç

Turkish Journal of Medical Sciences

Background/aim: Lymphovascular invasion (LVI) is considered a high-risk factor for recurrence in early-stage breast cancer, hence examination of LVI in pathological samples is an absolute recommendation. We aim to investigate predictive factors of LVI in preneoadjuvant chemotherapy (NAC) patients with estrogen receptor positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-) molecular subtypes of breast cancer. Materials and methods: One hundred and thirty-four patients treated with NAC were included in this study who were ER+/HER2-. The clinical characteristics of the patients, the data obtained from the core needle biopsy before NAC and the LVI status in the pathology …

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Optimal Screw Positioning In Cervical Pedicles To Avoid Complications, Kerem Atalar, Zafer Kutay Coşkun, Ahmet Memduh Kaymaz

Turkish Journal of Medical Sciences

Background/aim: Cervical instability can be caused by a variety of factors, including trauma, tumors, or infection. The cervical transpedicular screw (CPS) is one of the most modern procedures for treating cervical instability. Despite the fact that numerous innovative techniques for CPS have been proposed, the appropriate screw entry points and screw directions have yet to be thoroughly established. The aim of this study is to determine the screw insertion angles and screw entry point distances based on reference points, pedicle axis lengths, and pedicle axis intersections for each vertebra from cervical (C) C2 to C7 in both right and left …

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Chronic Obstructive Pulmonary Disease Phenotypes In Turkey: The Copet Study-A National, Multicenter Cross-Sectional Observational Study, Esra Yazar, Burcu Arpinar Yi̇ği̇tbaş, Can Öztürk, Mukadder Çalikoğlu, Gazi̇ Gülbaş, Muzaffer Onur Turan, Hülya Doğan Şahi̇n, Nurhan Sarioğlu, Nevi̇n Taci̇ Hoca, Fulsen Bozkuş, Seda Tural Önür, Ni̇hal Arzu Mi̇ri̇ci̇, Nalan Ogan, Ni̇lgün Yilmaz Demi̇rci̇, Burcu Yormaz

Turkish Journal of Medical Sciences

Background/aim: While mortality rates decrease in many chronic diseases, it continues to increase in COPD. This situation has led to the need to develop new approaches such as phenotypes in the management of COPD. We aimed to investigate the distribution, characteristics and treatment preference of COPD phenotypes in Turkey. Materials and methods: The study was designed as a national, multicenter, observational and cross-sectional. A total of 1141 stable COPD patients were included in the analysis. Results: The phenotype distribution was as follows: 55.7% nonexacerbators (NON-AE), 25.6% frequent exacerbators without chronic bronchitis (AE NON-CB), 13.9% frequent exacerbators with chronic bronchitis (AE-CB), …

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The Validity And Clinical Utility Of Axillary Ultrasonography-Guided Fine Needle Aspiration Biopsy In Detection Of Nodal Metastasis In Early-Stage Breast Cancer Patients: A Retrospective Single-Center Experience, Fi̇li̇z Taşçi, Yavuz Meti̇n, Nurgül Orhan Meti̇n, Maksude Esra Kadioğlu, Meli̇h Gaffar Gözükara, Si̇bel Kul

Turkish Journal of Medical Sciences

Background/aim: Assessing the validity and clinical utility of axillary ultrasonography (AUS)-guided fine needle aspiration biopsy (FNAB) in detection of nodal metastasis during preoperative axillary investigation in comparison to the histopathologic diagnosis in early-stage breast cancer. Materials and methods: A total of 279 operated primary breast cancer patients (age: 55.3 ± 12.8, ranged 17-90 years) were included. Data on AUS findings at the time of initial diagnosis (first look AUS), second-look AUS findings performed by the breast radiologist during breast biopsy procedure and the AUS-guided FNAB findings were evaluated with respect to the final histopathology report obtained through axillary surgery via …

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Evaluation Of Cardiovascular Changes In Patients With Gastric Wall Fat Halo Sign, Ali̇ Küpeli̇, Eser Bulut, Edhem Ünver, Gürkan Danişan

Turkish Journal of Medical Sciences

Background/aim: This study aims to investigate the relationship between gastric wall fat halo sign and potentially associated cardiovascular disease (CVD) in thoracic computed tomography (CT). Materials and methods: Between October 2020 and January 2021, 62 patients with gastric wall fat halo sign and 62 controls were evaluated with thorax CT. Patient's height, weight, body mass index (BMI), sex, age, comorbidities, laboratory parameters, diameters of cardiac axes, aorta and pulmonary artery; aorta and coronary artery calcium scores were recorded for the two groups. Results: No significant differences were found in sex, age, height, body weight or BMI between the two groups …

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Clinical Applications Of Internal Fixation Via The Volar Approach With Pronator Quadratus Preservation For Distal Radius Fractures, Jie Zhong, Xiaohui Li, Fuxin Lv, Naiyue Cao, Dangke Li

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to investigate the success rate of volar plate treatment of distal radius fractures with preservation of the pronator anterior muscle; the incidence of complications, such as infection, vascular nerve injury, and tendon injury; fracture healing rate; and changes in muscle anatomy. Materials and methods: The Henry approach was adopted to treat distal radius fractures with pronator quadratus (PQ) preservation on a trial basis. Between June 2015 and January 2017, 46 cases of distal radius fractures were considered according to the Arbeitsgemeinschaft für Osteosynthesefragen (AO) classification. The PQ was preserved, the distal margin was …

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Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma. The aim of this study is to present the results of the patients we treated with the diagnosis of EMC as an oncology reference center. Materials and methods: Information on 13 patients diagnosed with EMC between 2006 and 2018 was retrospectively reviewed. Patients' demographic information, tumor sizes, surgical treatments, chemotherapy and radiotherapy statuses, follow-up times, recurrences, and metastases were recorded. Results: Mean patient age was 53.6 ± 15 years (range: 28-73). In 8 patients, the tumor was located in the lower limbs, most commonly in the thigh (46.2%). Mean …

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A Single-Center Experience Of Magnetic Resonance Imaging Findings Of Fetal Sacrococcygeal Teratomas, Mesude Tosun, İsa Çam, Hande Uslu, Yasemi̇n Doğan, Yonca Anik

Turkish Journal of Medical Sciences

Background/aim: Sacrococcygeal teratomas (SCT) are known as rare tumors, but they are the most common tumor in fetuses and newborns. This study aims to present fetal magnetic resonance imaging (MRI) findings of SCT diagnosed prenatally and compare them with that of the prenatal Ultrasound (US) findings. Materials and methods: Eleven patients diagnosed as SCT prenatally by US and further assessed by MRI are included. MRI was performed via a 1.5-T magnet with a body coil. The presence, size, content extension, and compressive effects of each mass were determined and correlated with US findings and with postnatal examinations, including surgery and …

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Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca

Turkish Journal of Medical Sciences

Background/aim: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Materials and methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the …

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Venom Immunotherapy And Difficulties Encountered Before And During Immunotherapy: Double Sensitization, Systemic Reactions, Treatment With Omalizumab, And High Dose Vit, Gülden Paçaci Çeti̇n, İnsu Yilmaz, Murat Türk, Bahar Arslan, Saki̇ne Nazi̇k Bahçeci̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Venom immunotherapy (VIT) is the most effective treatment method to prevent recurrent systemic reactions to Hymenoptera stings. In this study, the demographic characteristics of VIT patients, the success rates of VIT, the difficulties we encountered during VIT, and solutions for these difficulties in our clinic were presented. Materials and methods: We retrospectively analyzed patients with venom allergy who applied venom immunotherapy between 2013- 2020. Data on age, gender, Hymenoptera species with the first reaction, grade of the reaction, beekeeping history, skin prick and specific IgE and component results, double sensitization, blood groups, and reactions with VIT and/or sting during …

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Amount Of Reoperation Following Surgical Repair Of Nonsyndromic Craniosynostosis At A Single Center, Duygu Baykal, Rabi̇a Nur Balçin, Mevlüt Özgür Taşkapilioğlu

Turkish Journal of Medical Sciences

Background/aim: Craniosynostosis is a deformity of the skull that occurs as a result of early fusion of one or more cranial sutures and can be accompanied by neurological deficits. Craniosynostosis can be classified as syndromic or nonsyndromic according to the type of suture involved. Surgical treatment of craniosynostosis in infants basically involves loosening and opening the fused sutures to reduce intracranial pressure, allow the brain to grow, and also fix the skull shape. However, in such cases there is a risk of resynostosis after surgery. According to the literature, resynostosis rates vary between 0% and 70%. In this study, we …

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Evolution Of Clinically Isolated Syndrome To Pediatric-Onset Multiple Sclerosis And A Review Of The Literature, İsmai̇l Solmaz, İbrahi̇m Hali̇l Öncel

Turkish Journal of Medical Sciences

Background/aim: Clinically isolated syndrome (CIS) may be the first presentation of pediatric onset multiple sclerosis (POMS). We retrospectively evaluated the clinical and laboratory data of pediatric CIS (pCIS) patients who were diagnosed with POMS upon followup for any predictive variables. We also reviewed the literature concerning the management of pCIS. Materials and methods: This single-center study involved patients who had pCIS in childhood that converted to POMS during followup between 2011 and 2021. Sixteen patients were included in the study. The data were evaluated retrospectively and analyzed with descriptive statistics. Results: The majority of the pCIS patients were female (F/M: …

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Effect Of Cell Salvage On Bleeding, Transfusion Of Blood Products, And Bleeding Parameters In Patients Undergoing Liver Transplantation With Intraoperative Massive Blood Transfusion, Tümay Uludağ Yanaral, Peli̇n Karaaslan

Turkish Journal of Medical Sciences

Background/aim: Autologous transfusion using a cell saver system has been used in liver transplantation with controversial outcomes. Its efficiency in patients with massive intraoperative transfusion has not been studied yet. This study aimed to evaluate effect of cell salvage (CS) on intraoperative bleeding and transfusion practices in liver transplantation with massive intraoperative transfusion. Materials and methods: Consecutive patients aged ≥18 years with intraoperative massive blood transfusion (≥ 6 units) between March 2014 and September 2020 were included. Patients subjected to CS were grouped as CS, whereas other patients were grouped as control. Number of transfused red blood cells was study's …

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Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu

Turkish Journal of Medical Sciences

Background/aim: The use of Transcranial Magnetic Stimulation (TMS) in the add-on treatment of patients with treatment-resistant depression (TRD) is becoming more common. This study aims to investigate the efficacy of TMS on depression and accompanying anxiety symptoms among patients with TRD. Materials and methods: The current study was conducted with 38 patients diagnosed with TRD. The patients were randomly divided into two groups and received 20 sessions of high-frequency (10Hz) TMS and 20 sessions of sham TMS to the left dorsolateral prefrontal cortex in a double-blind and cross-over fashion without a change in their pharmacotherapy. In the clinical evaluation, Hamilton …

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Full-Text Articles in Entire DC Network

A Device That Facilitates Screwing At An Appropriate Angle In Quadrilateral Surface Fractures: 105-Degree Drill Attachment, Emre Gültaç, Cem Yalin Kilinç, Fati̇h İlker Can, İsmai̇l Gökhan Şahi̇n, Ahmet Emrah Açan, Çağatay Gemci̇, Nevres Hürri̇yet Aydoğan

Turkish Journal of Medical Sciences

Medically Important Candida Spp. Identification: An Era Beyond Traditional Methods, Ebru Evren, Juli̇de Sedef Göçmen, Elvan Hortaç İştar, Şükran Yavuzdemi̇r, Fazil Alper Tekeli̇, Yasemi̇n Yavuz, Zeynep Ceren Karahan

Turkish Journal of Medical Sciences

Classical Heart Rate Variability And Non-Linear Heart Rate Analysis In Mice Under Na-Pentobarbital And Ketamine/Xylazine Anesthesia., Hasan Kazdağli, Hasan Fehmi̇ Özel, Mustafa Özbek, Şüheda Alpay, Mürüvvet Alenbey

Turkish Journal of Medical Sciences

Response To Letter To The Editor, Esra İşçi̇ Bostanci, Yasi̇n Durmuş, Si̇nem Ayşe Duru Çöteli̇, Fulya Kayikçioğlu, Nuretti̇n Boran

Turkish Journal of Medical Sciences

Evidence-Based Information About Intermittent Fasting In Diabetes Patients: Useful Or Harmful?, Mustafa Altay

Turkish Journal of Medical Sciences

Turkish Journal of Medical Sciences

The Role Of Cd8+ Regulatory T Cells And B Cell Subsets In Patients With Covid-19, Hülya Uçaryilmaz, Di̇lek Ergün, Hüsametti̇n Vatansev, Hande Köksal, Onur Ural, Uğur Arslan, Hasi̇be Artaç

Turkish Journal of Medical Sciences

Comparison Of Intraoperative Biliary Anastomosis Stenting Technique In Living-Donor Liver Transplantation: Review Of 41 Patients, Ramazan Dönmez, Şener Balas, Ufuk Utku Göktuğ, Ertan Emek, Yaman Tokat

Turkish Journal of Medical Sciences

Investigation Of Cochlear Microphonics Recorded With Different Stimulus Types, Özgecan Güneşer, Ayşe Arzu Yi̇ği̇t, Asuman Alniaçik, Kürşat Yanarateş, Eda Çakmak

Turkish Journal of Medical Sciences

The Role Of Vitamin D-Synthesizing Enzyme Cyp27b1 In Systemic Lupus Erythematosus, Man Luo, Jing Liu, Yeshuang Yuan, Yong Chen, Guohua Yuan

Turkish Journal of Medical Sciences

Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir

Turkish Journal of Medical Sciences

Turkish Journal of Medical Sciences

Turkish Journal of Medical Sciences

The Effect Of Immunonutrition On Tumor Infiltrative T Lymphocytes And Regulatory T Cells In Rectal Tumor Patients Receiving Neoadjuvant Chemoradiotherapy: A Prospective Randomized Clinical Study, Mehmet Onur Gül, Cebrai̇l Akyüz, Selvi̇naz Özkara

Turkish Journal of Medical Sciences

Effect Of Perioperative Factors On The Prognosis Of Patients With Hepatocellular Carcinoma Who Underwent Hepatectomy, Lining Xu, Yingying Xu, Guiping Li, Bo Yang

Turkish Journal of Medical Sciences

Morbid Obesity Leads To Increased Skin Autofluorescence Independent Of Metabolic Syndrome Components, Tuğçe Apaydin, Di̇lek Yavuz

Turkish Journal of Medical Sciences

Predictors Of Lymphovascular Invasion In Estrogen Receptor Positive/Her-2 Negative Breast Cancer Patients Treated With Neoadjuvant Chemotherapy, Eyyüp Çavdar, Yakup İri̇ağaç

Turkish Journal of Medical Sciences

Optimal Screw Positioning In Cervical Pedicles To Avoid Complications, Kerem Atalar, Zafer Kutay Coşkun, Ahmet Memduh Kaymaz

Turkish Journal of Medical Sciences

Turkish Journal of Medical Sciences

Turkish Journal of Medical Sciences

Evaluation Of Cardiovascular Changes In Patients With Gastric Wall Fat Halo Sign, Ali̇ Küpeli̇, Eser Bulut, Edhem Ünver, Gürkan Danişan

Turkish Journal of Medical Sciences

Clinical Applications Of Internal Fixation Via The Volar Approach With Pronator Quadratus Preservation For Distal Radius Fractures, Jie Zhong, Xiaohui Li, Fuxin Lv, Naiyue Cao, Dangke Li

Turkish Journal of Medical Sciences

Surgical Outcomes Of Extraskeletal Myxoid Chondrosarcoma, Coşkun Ulucaköy, İsmai̇l Burak Atalay, Ali̇ekber Yapar, Ahmet Yi̇ği̇t Kaptan, İzzet Bi̇ngöl, Mehmet Doğan, Mehmet Fati̇h Ekşi̇oğlu

Turkish Journal of Medical Sciences

A Single-Center Experience Of Magnetic Resonance Imaging Findings Of Fetal Sacrococcygeal Teratomas, Mesude Tosun, İsa Çam, Hande Uslu, Yasemi̇n Doğan, Yonca Anik

Turkish Journal of Medical Sciences

Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca

Turkish Journal of Medical Sciences

Venom Immunotherapy And Difficulties Encountered Before And During Immunotherapy: Double Sensitization, Systemic Reactions, Treatment With Omalizumab, And High Dose Vit, Gülden Paçaci Çeti̇n, İnsu Yilmaz, Murat Türk, Bahar Arslan, Saki̇ne Nazi̇k Bahçeci̇oğlu

Turkish Journal of Medical Sciences

Amount Of Reoperation Following Surgical Repair Of Nonsyndromic Craniosynostosis At A Single Center, Duygu Baykal, Rabi̇a Nur Balçin, Mevlüt Özgür Taşkapilioğlu

Turkish Journal of Medical Sciences

Evolution Of Clinically Isolated Syndrome To Pediatric-Onset Multiple Sclerosis And A Review Of The Literature, İsmai̇l Solmaz, İbrahi̇m Hali̇l Öncel

Turkish Journal of Medical Sciences

Effect Of Cell Salvage On Bleeding, Transfusion Of Blood Products, And Bleeding Parameters In Patients Undergoing Liver Transplantation With Intraoperative Massive Blood Transfusion, Tümay Uludağ Yanaral, Peli̇n Karaaslan

Turkish Journal of Medical Sciences

Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu

Turkish Journal of Medical Sciences